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Conserved domains on  [gi|74179537|dbj|BAE22455|]
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unnamed protein product, partial [Mus musculus]

Protein Classification

integrin alpha( domain architecture ID 12192572)

integrin alpha forms a heterodimer with integrin beta to mediate cell-extracellular matrix and cell-cell interactions; integrin alpha is a component of integrin, a cell adhesion molecule that mediates cell-extracellular matrix and cell-cell interactions

CATH:  2.60.40.1460|2.130.10.130
Gene Ontology:  GO:0007155|GO:0008305|GO:0005178|GO:0046872
PubMed:  3028640|2199285|12297042|12826403|14689578|12361595|12234368
SCOP:  4003137

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Integrin_alpha2 super family cl26747
Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C ...
 483-675 7.48e-78

Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of pfam01839 repeats and to the N-terminus of the pfam00357 cytoplasmic region. This region is composed of three immunoglobulin-like domains.


The actual alignment was detected with superfamily member pfam08441:

Pssm-ID: 462478 [Multi-domain]  Cd Length: 449  Bit Score: 255.71  E-value: 7.48e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74179537   483 RPVVTVDAQLLLHPMIINLENKTCQIPefPTPVACFSVRVCASIAGQSI-SNTIALLAEVQLDFLKQKGAIKRTLFLHNH 561
Cdd:pfam08441   1 RPVVSVSASLQVEPNSINPEKKNCTLT--GTPVSCFTVRACFSYTGKPIpNPSLVLNYELELDRQKKKGLPPRVLFLDSQ 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74179537   562 QSHFTFPFVMKQQKSLHCQDFMVYLRDEteFRDKLSPINISLNYSL--DDSTFKDSLEVKPILNHYRDNVVTEQAHILVD 639
Cdd:pfam08441  79 QPSLTGTLVLLSQGRKVCRTTKAYLRDE--FRDKLSPIVISLNYSLrvDPRAPSDLPGLKPILDQNQPSTVQEQANFLKD 156

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 74179537   640 CGEDNLCVPDLKLSARPD----KHQIIIGDENHLMLIINA 675
Cdd:pfam08441 157 CGEDNVCVPDLQLSAKFDsresDEPLLLGDDNDLALEITV 196
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 382-436 1.56e-13

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 65.47  E-value: 1.56e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 74179537    382 FGRFGSSVAHLGDLNQDGYNDIAIGVPFAGKDQR-GKVLIYNGNPRGLHSKPSQVL 436
Cdd:smart00191   2 GSYFGYSVAGVGDVNGDGYPDLLVGAPRANDAGEtGAVYVYFGSSGGGNSIPLQNL 57
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 316-364 1.27e-09

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 54.30  E-value: 1.27e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 74179537    316 MASYFGYTVV-VSDVNNDGMDDILVGAPlfmereFESNPREVGQVYLYLQ 364
Cdd:smart00191   1 PGSYFGYSVAgVGDVNGDGYPDLLVGAP------RANDAGETGAVYVYFG 44
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 53-111 3.21e-07

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 47.37  E-value: 3.21e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 74179537     53 GSYFGYSLDFY--IPGARTASVLVGAPKANTSQpdivEGGAVYYCPWpSERSAQCKQIPFD 111
Cdd:smart00191   2 GSYFGYSVAGVgdVNGDGYPDLLVGAPRANDAG----ETGAVYVYFG-SSGGGNSIPLQNL 57
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 447-491 4.75e-05

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 41.59  E-value: 4.75e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 74179537    447 SGFGFSLRGDADIDKNDYPDLLVGAFGKGKVAVYRARPVVTVDAQ 491
Cdd:smart00191   3 SYFGYSVAGVGDVNGDGYPDLLVGAPRANDAGETGAVYVYFGSSG 47
 
Name Accession Description Interval E-value
Integrin_alpha2 pfam08441
Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C ...
 483-675 7.48e-78

Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of pfam01839 repeats and to the N-terminus of the pfam00357 cytoplasmic region. This region is composed of three immunoglobulin-like domains.


Pssm-ID: 462478 [Multi-domain]  Cd Length: 449  Bit Score: 255.71  E-value: 7.48e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74179537   483 RPVVTVDAQLLLHPMIINLENKTCQIPefPTPVACFSVRVCASIAGQSI-SNTIALLAEVQLDFLKQKGAIKRTLFLHNH 561
Cdd:pfam08441   1 RPVVSVSASLQVEPNSINPEKKNCTLT--GTPVSCFTVRACFSYTGKPIpNPSLVLNYELELDRQKKKGLPPRVLFLDSQ 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74179537   562 QSHFTFPFVMKQQKSLHCQDFMVYLRDEteFRDKLSPINISLNYSL--DDSTFKDSLEVKPILNHYRDNVVTEQAHILVD 639
Cdd:pfam08441  79 QPSLTGTLVLLSQGRKVCRTTKAYLRDE--FRDKLSPIVISLNYSLrvDPRAPSDLPGLKPILDQNQPSTVQEQANFLKD 156

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 74179537   640 CGEDNLCVPDLKLSARPD----KHQIIIGDENHLMLIINA 675
Cdd:pfam08441 157 CGEDNVCVPDLQLSAKFDsresDEPLLLGDDNDLALEITV 196
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 382-436 1.56e-13

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 65.47  E-value: 1.56e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 74179537    382 FGRFGSSVAHLGDLNQDGYNDIAIGVPFAGKDQR-GKVLIYNGNPRGLHSKPSQVL 436
Cdd:smart00191   2 GSYFGYSVAGVGDVNGDGYPDLLVGAPRANDAGEtGAVYVYFGSSGGGNSIPLQNL 57
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 316-364 1.27e-09

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 54.30  E-value: 1.27e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 74179537    316 MASYFGYTVV-VSDVNNDGMDDILVGAPlfmereFESNPREVGQVYLYLQ 364
Cdd:smart00191   1 PGSYFGYSVAgVGDVNGDGYPDLLVGAP------RANDAGETGAVYVYFG 44
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 385-421 5.25e-08

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 49.05  E-value: 5.25e-08
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 74179537   385 FGSSVAhLGDLNQDGYNDIAIGVPFAGKDQRGKVLIY 421
Cdd:pfam01839   1 FGYSVA-VGDLNGDGYADLAVGAPGEGGAGAGAVYVL 36
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 53-111 3.21e-07

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 47.37  E-value: 3.21e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 74179537     53 GSYFGYSLDFY--IPGARTASVLVGAPKANTSQpdivEGGAVYYCPWpSERSAQCKQIPFD 111
Cdd:smart00191   2 GSYFGYSVAGVgdVNGDGYPDLLVGAPRANDAG----ETGAVYVYFG-SSGGGNSIPLQNL 57
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 320-362 8.15e-07

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 45.58  E-value: 8.15e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 74179537   320 FGYTVVVSDVNNDGMDDILVGAPLFmerefesNPREVGQVYLY 362
Cdd:pfam01839   1 FGYSVAVGDLNGDGYADLAVGAPGE-------GGAGAGAVYVL 36
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 447-491 4.75e-05

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 41.59  E-value: 4.75e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 74179537    447 SGFGFSLRGDADIDKNDYPDLLVGAFGKGKVAVYRARPVVTVDAQ 491
Cdd:smart00191   3 SYFGYSVAGVGDVNGDGYPDLLVGAPRANDAGETGAVYVYFGSSG 47
 
Name Accession Description Interval E-value
Integrin_alpha2 pfam08441
Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C ...
 483-675 7.48e-78

Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of pfam01839 repeats and to the N-terminus of the pfam00357 cytoplasmic region. This region is composed of three immunoglobulin-like domains.


Pssm-ID: 462478 [Multi-domain]  Cd Length: 449  Bit Score: 255.71  E-value: 7.48e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74179537   483 RPVVTVDAQLLLHPMIINLENKTCQIPefPTPVACFSVRVCASIAGQSI-SNTIALLAEVQLDFLKQKGAIKRTLFLHNH 561
Cdd:pfam08441   1 RPVVSVSASLQVEPNSINPEKKNCTLT--GTPVSCFTVRACFSYTGKPIpNPSLVLNYELELDRQKKKGLPPRVLFLDSQ 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74179537   562 QSHFTFPFVMKQQKSLHCQDFMVYLRDEteFRDKLSPINISLNYSL--DDSTFKDSLEVKPILNHYRDNVVTEQAHILVD 639
Cdd:pfam08441  79 QPSLTGTLVLLSQGRKVCRTTKAYLRDE--FRDKLSPIVISLNYSLrvDPRAPSDLPGLKPILDQNQPSTVQEQANFLKD 156

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 74179537   640 CGEDNLCVPDLKLSARPD----KHQIIIGDENHLMLIINA 675
Cdd:pfam08441 157 CGEDNVCVPDLQLSAKFDsresDEPLLLGDDNDLALEITV 196
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 382-436 1.56e-13

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 65.47  E-value: 1.56e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 74179537    382 FGRFGSSVAHLGDLNQDGYNDIAIGVPFAGKDQR-GKVLIYNGNPRGLHSKPSQVL 436
Cdd:smart00191   2 GSYFGYSVAGVGDVNGDGYPDLLVGAPRANDAGEtGAVYVYFGSSGGGNSIPLQNL 57
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 316-364 1.27e-09

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 54.30  E-value: 1.27e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 74179537    316 MASYFGYTVV-VSDVNNDGMDDILVGAPlfmereFESNPREVGQVYLYLQ 364
Cdd:smart00191   1 PGSYFGYSVAgVGDVNGDGYPDLLVGAP------RANDAGETGAVYVYFG 44
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 385-421 5.25e-08

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 49.05  E-value: 5.25e-08
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 74179537   385 FGSSVAhLGDLNQDGYNDIAIGVPFAGKDQRGKVLIY 421
Cdd:pfam01839   1 FGYSVA-VGDLNGDGYADLAVGAPGEGGAGAGAVYVL 36
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 53-111 3.21e-07

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 47.37  E-value: 3.21e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 74179537     53 GSYFGYSLDFY--IPGARTASVLVGAPKANTSQpdivEGGAVYYCPWpSERSAQCKQIPFD 111
Cdd:smart00191   2 GSYFGYSVAGVgdVNGDGYPDLLVGAPRANDAG----ETGAVYVYFG-SSGGGNSIPLQNL 57
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 320-362 8.15e-07

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 45.58  E-value: 8.15e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 74179537   320 FGYTVVVSDVNNDGMDDILVGAPLFmerefesNPREVGQVYLY 362
Cdd:pfam01839   1 FGYSVAVGDLNGDGYADLAVGAPGE-------GGAGAGAVYVL 36
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 447-491 4.75e-05

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 41.59  E-value: 4.75e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 74179537    447 SGFGFSLRGDADIDKNDYPDLLVGAFGKGKVAVYRARPVVTVDAQ 491
Cdd:smart00191   3 SYFGYSVAGVGDVNGDGYPDLLVGAPRANDAGETGAVYVYFGSSG 47
FG-GAP_3 pfam13517
FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...
 328-405 4.84e-05

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.


Pssm-ID: 433275 [Multi-domain]  Cd Length: 61  Bit Score: 41.44  E-value: 4.84e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 74179537   328 DVNNDGMDDILVGAPlfmerefesnprevGQVYLYLQASALLFQDPQVLTGTETFGRFGssvAHLGDLNQDGYNDIAI 405
Cdd:pfam13517   1 DLDGDGKLDLVVAND--------------GGLRLYLNNGDGTFTFITSVSLGGGGGGLS---VAVGDLDGDGRLDLLV 61
FG-GAP_3 pfam13517
FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...
 394-469 1.92e-03

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.


Pssm-ID: 433275 [Multi-domain]  Cd Length: 61  Bit Score: 36.82  E-value: 1.92e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 74179537   394 DLNQDGYNDIaigvpFAGKDQRGKVLIYNGNPRGLHSKPSQVLQGIWGSQTIPsgfgfslrgdADIDKNDYPDLLV 469
Cdd:pfam13517   1 DLDGDGKLDL-----VVANDGGLRLYLNNGDGTFTFITSVSLGGGGGGLSVAV----------GDLDGDGRLDLLV 61
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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