NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|74205834|dbj|BAE23214|]
View 

unnamed protein product [Mus musculus]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 49-358 6.98e-148

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17442:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 375  Bit Score: 423.06  E-value: 6.98e-148
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834  49 ALFLIMGSTGVVEAMEIMLIAVVSPVIRCEWQLENWQVAFVTTMVFFGYMVSSILFGLLADRYGRWKILLLSFLWGAYFS 128
Cdd:cd17442   1 LLFLIMGSTGVAEAMEIMLLAVVSPEIRCEWHLEDWQVALVTTMVFFGYMVFSILLGLLADRYGRWKILLLSFVWGAYFS 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834 129 LLTSFSPSYIWFVFLRTMVGCGVSGHAQGLIIKTEFLPTKYRGYMLPLSQVFWLAGSLLIISMASVVIPTIGWRWLIRIA 208
Cdd:cd17442  81 LLTSFAPSYIWFVFLRCMVGCGVSGHSQGLIIKTEFLPTKYRGYMLPLSQIFWLAGSLLIIGLASVVIPTLGWRWLIRFA 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834 209 SIPGIILIMAFKFIPesarfnvstgntqaalntlesiakmnrsvmpegqlvepilekrgrfadlldskylRTTLQIWIIW 288
Cdd:cd17442 161 SIPGIILIVVFKFIP-------------------------------------------------------RTTLQIWVIW 185

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834 289 LGISFAYYGVILASAELLERDLVCGSKSESEpevvETTGDSGEGLSPCYCHIFAPSDYRTMIISTLGEIA 358
Cdd:cd17442 186 LGISFAYYGVILASSELLERNLLCGSDPSDE----EAGIKHIESESPCYCHMFNPSDYQTMIISTLGEIA 251
 
Name Accession Description Interval E-value
MFS_SVOPL cd17442
Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; ...
 49-358 6.98e-148

Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) or SVOP-like protein is a transporter-like protein that shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. It belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341000 [Multi-domain]  Cd Length: 375  Bit Score: 423.06  E-value: 6.98e-148
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834  49 ALFLIMGSTGVVEAMEIMLIAVVSPVIRCEWQLENWQVAFVTTMVFFGYMVSSILFGLLADRYGRWKILLLSFLWGAYFS 128
Cdd:cd17442   1 LLFLIMGSTGVAEAMEIMLLAVVSPEIRCEWHLEDWQVALVTTMVFFGYMVFSILLGLLADRYGRWKILLLSFVWGAYFS 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834 129 LLTSFSPSYIWFVFLRTMVGCGVSGHAQGLIIKTEFLPTKYRGYMLPLSQVFWLAGSLLIISMASVVIPTIGWRWLIRIA 208
Cdd:cd17442  81 LLTSFAPSYIWFVFLRCMVGCGVSGHSQGLIIKTEFLPTKYRGYMLPLSQIFWLAGSLLIIGLASVVIPTLGWRWLIRFA 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834 209 SIPGIILIMAFKFIPesarfnvstgntqaalntlesiakmnrsvmpegqlvepilekrgrfadlldskylRTTLQIWIIW 288
Cdd:cd17442 161 SIPGIILIVVFKFIP-------------------------------------------------------RTTLQIWVIW 185

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834 289 LGISFAYYGVILASAELLERDLVCGSKSESEpevvETTGDSGEGLSPCYCHIFAPSDYRTMIISTLGEIA 358
Cdd:cd17442 186 LGISFAYYGVILASSELLERNLLCGSDPSDE----EAGIKHIESESPCYCHMFNPSDYQTMIISTLGEIA 251
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 22-305 1.89e-55

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 189.46  E-value: 1.89e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834    22 PEPQQKETKTFTVEDAVETIGFGRFHIALFlIMGSTGVVEAMEIML--IAVVSPVIRCEWQL---ENWQVAFVTTMVFFG 96
Cdd:TIGR00898  61 PDGRPESCLRFMVDQWANPSLLGCEPLKLS-DLGLAATEPCLDGWEysYDTFSSTIVTEWDLvceDAWKVDLTQSCFFVG 139

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834    97 YMVSSILFGLLADRYGRWKILLLSFLWGAYFSLLTSFSPSYIWFVFLRTMVGCGVSGHA-QGLIIKTEFLPTKYRGYMLP 175
Cdd:TIGR00898 140 VLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWvQAVVLNTEFLPKKQRAIVGT 219

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834   176 LSQVFWLAGSLLIISMAsVVIPtiGWRWLIRIASIPGIILIMAFKFIPESARFNVSTGNTQAALNTLESIAKMNRSVMPE 255
Cdd:TIGR00898 220 LIQVFFSLGLVLLPLVA-YFIP--DWRWLQLAVSLPTFLFFLLSWFVPESPRWLISQGRIEEALKILQRIAKINGKKLPA 296

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 74205834   256 GQLVEPILE------KRGRFADLLDSKYLR-TTLQIWIIWLGISFAYYGVILASAEL 305
Cdd:TIGR00898 297 EVLSLSLEKdlssskKQYSFLDLFRTPNLRkTTLCLMMLWFTTAFSYYGLVLDLGNL 353
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
44-216 3.19e-23

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 99.17  E-value: 3.19e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834  44 GRFHIALFLIMGSTGVVEAMEIMLIAVVSPVIRCEWQLENWQVAFVTTMVFFGYMVSSILFGLLADRYGRWKILLLSFLW 123
Cdd:COG2271   5 SRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLL 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834 124 GAYFSLLTSFSPSYIWFVFLRTMVGCGVSG-HAQGLIIKTEFLPTKYRGYMLPLSQVFWLAGSLLIISMASVVIPTIGWR 202
Cdd:COG2271  85 WGLATLLFGFATSFWQLLLLRFLLGLGEAGfFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWR 164

                       170
                ....*....|....
gi 74205834 203 WLIRIASIPGIILI 216
Cdd:COG2271 165 AAFLILGLPGLLLA 178
Sugar_tr pfam00083
Sugar (and other) transporter;
85-238 5.77e-13

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 69.61  E-value: 5.77e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834    85 QVAFVTTMVFFGYMVSSILFGLLADRYGRWKILLLSFLWGAYFSLLTSFSPSYIWFVFLrtMVGCGVSGHAQGLIIKT-- 162
Cdd:pfam00083  47 LSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAKGKWSVYQL--IVGRVLVGIGVGGASVLap 124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834   163 ----EFLPTKYRGYMLPLSQVFWLAGSLL-IISMASVVI--PTIGWRWLIRIASIPGIILIMAFKFIPESARFNVSTGNT 235
Cdd:pfam00083 125 myisEIAPKKLRGALGSLYQLAITFGILLaYIFGLGLNKtsNSDGWRIPLGLQLVPALLLIIGLLFLPESPRWLVEKGRL 204


                  ...
gi 74205834   236 QAA 238
Cdd:pfam00083 205 EEA 207
xylE PRK10077
D-xylose transporter XylE; Provisional
 88-245 6.51e-08

D-xylose transporter XylE; Provisional


Pssm-ID: 182225 [Multi-domain]  Cd Length: 479  Bit Score: 54.31  E-value: 6.51e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834   88 FVTTMVFFGYMVSSILFGLLADRYGRWKIL-------LLSFLWGAY----FSLLTSFSPSYIW-FVFLRTMVGCGVsGHA 155
Cdd:PRK10077  59 FCVASALIGCIIGGALGGYCSNRFGRRDSLkiaavlfFISALGSAWpefgFTSIGPDNTGYVPeFVIYRIIGGIGV-GLA 137

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834  156 QGL--IIKTEFLPTKYRGYMLPLSQVFWLAGSLLII--------SMASVVIPTIGWRWLIRIASIPGIILIMAFKFIPES 225
Cdd:PRK10077 138 SMLspMYIAEIAPAHIRGKLVSFNQFAIIFGQLVVYfvnyfiarSGDASWLNTDGWRYMFASEAIPALLFLMLLYFVPET 217

                        170       180
                 ....*....|....*....|
gi 74205834  226 ARFNVSTGNTQAALNTLESI 245
Cdd:PRK10077 218 PRYLMSRGKQEQAEGILRKI 237
 
Name Accession Description Interval E-value
MFS_SVOPL cd17442
Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; ...
 49-358 6.98e-148

Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) or SVOP-like protein is a transporter-like protein that shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. It belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341000 [Multi-domain]  Cd Length: 375  Bit Score: 423.06  E-value: 6.98e-148
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834  49 ALFLIMGSTGVVEAMEIMLIAVVSPVIRCEWQLENWQVAFVTTMVFFGYMVSSILFGLLADRYGRWKILLLSFLWGAYFS 128
Cdd:cd17442   1 LLFLIMGSTGVAEAMEIMLLAVVSPEIRCEWHLEDWQVALVTTMVFFGYMVFSILLGLLADRYGRWKILLLSFVWGAYFS 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834 129 LLTSFSPSYIWFVFLRTMVGCGVSGHAQGLIIKTEFLPTKYRGYMLPLSQVFWLAGSLLIISMASVVIPTIGWRWLIRIA 208
Cdd:cd17442  81 LLTSFAPSYIWFVFLRCMVGCGVSGHSQGLIIKTEFLPTKYRGYMLPLSQIFWLAGSLLIIGLASVVIPTLGWRWLIRFA 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834 209 SIPGIILIMAFKFIPesarfnvstgntqaalntlesiakmnrsvmpegqlvepilekrgrfadlldskylRTTLQIWIIW 288
Cdd:cd17442 161 SIPGIILIVVFKFIP-------------------------------------------------------RTTLQIWVIW 185

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834 289 LGISFAYYGVILASAELLERDLVCGSKSESEpevvETTGDSGEGLSPCYCHIFAPSDYRTMIISTLGEIA 358
Cdd:cd17442 186 LGISFAYYGVILASSELLERNLLCGSDPSDE----EAGIKHIESESPCYCHMFNPSDYQTMIISTLGEIA 251
MFS_SVOP_like cd17372
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ...
 51-358 2.54e-117

Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340930 [Multi-domain]  Cd Length: 367  Bit Score: 344.90  E-value: 2.54e-117
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834  51 FLIMGSTGVVEAMEIMLIAVVSPVIRCEWQLENWQVAFVTTMVFFGYMVSSILFGLLADRYGRWKILLLSFLWGAYFSLL 130
Cdd:cd17372   1 LAYAGMGWVAEAMEMMLLSFVGPAVQCEWNLSAWQVALITSVVFAGMMIGSYLWGIVSDKYGRRKGLIISALWTFYAGFL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834 131 TSFSPSYIWFVFLRTMVGCGVSGHAQGLIIKTEFLPTKYRGYMLPLSQVFWLAGSLLIISMASVVIPTIGWRWLIRIASI 210
Cdd:cd17372  81 SAFAPNYMWLIILRCLVGLGLGGGPQLASWYLEFLPAKSRGTWMVLFSVFWTVGTIFEASLAWLVMPRLGWRWLLAFSSV 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834 211 PGIILIMAFKFIPesarfnvstgntqaalntlesiakmnrsvmpegqlvepilekrgrfadlldskylRTTLQIWIIWLG 290
Cdd:cd17372 161 PSSLLLVFYRWTP-------------------------------------------------------KTTLLLWVIWFG 185

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 74205834 291 ISFAYYGVILASAELLERDLVCGSKSESepevvettgDSGEGLSPCYCHIFAPSDYRTMIISTLGEIA 358
Cdd:cd17372 186 NAFAYYGVVLLTTELNNSHNVCGSKSDS---------DSGESPTEKQCRNSNDVDYRDVFIATFAEFP 244
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 22-305 1.89e-55

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 189.46  E-value: 1.89e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834    22 PEPQQKETKTFTVEDAVETIGFGRFHIALFlIMGSTGVVEAMEIML--IAVVSPVIRCEWQL---ENWQVAFVTTMVFFG 96
Cdd:TIGR00898  61 PDGRPESCLRFMVDQWANPSLLGCEPLKLS-DLGLAATEPCLDGWEysYDTFSSTIVTEWDLvceDAWKVDLTQSCFFVG 139

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834    97 YMVSSILFGLLADRYGRWKILLLSFLWGAYFSLLTSFSPSYIWFVFLRTMVGCGVSGHA-QGLIIKTEFLPTKYRGYMLP 175
Cdd:TIGR00898 140 VLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWvQAVVLNTEFLPKKQRAIVGT 219

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834   176 LSQVFWLAGSLLIISMAsVVIPtiGWRWLIRIASIPGIILIMAFKFIPESARFNVSTGNTQAALNTLESIAKMNRSVMPE 255
Cdd:TIGR00898 220 LIQVFFSLGLVLLPLVA-YFIP--DWRWLQLAVSLPTFLFFLLSWFVPESPRWLISQGRIEEALKILQRIAKINGKKLPA 296

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 74205834   256 GQLVEPILE------KRGRFADLLDSKYLR-TTLQIWIIWLGISFAYYGVILASAEL 305
Cdd:TIGR00898 297 EVLSLSLEKdlssskKQYSFLDLFRTPNLRkTTLCLMMLWFTTAFSYYGLVLDLGNL 353
MFS_SVOP cd17441
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic ...
 52-356 2.54e-51

Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein (SVOP) is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. This SVOP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340999 [Multi-domain]  Cd Length: 372  Bit Score: 175.39  E-value: 2.54e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834  52 LIMGSTGVVEAMEIMLIAVVSPVIRCEWQLENWQVAFVTTMVFFGYMVSSILFGLLADRYGRWKILLLSFLWGAYFSLLT 131
Cdd:cd17441   2 ILTGLAWMADAMEMMILSILAPQLHCEWRLPSWQVALLTSVVFIGMMLSSSLWGNISDQYGRKTGLKISVLWTLYYGILS 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834 132 SFSPSYIWFVFLRTMVGCGVSGHAQGLIIKTEFLPTKYRGYMLPLSQVFWLAGSLLIISMASVVIPTIGWRWLIRIASIP 211
Cdd:cd17441  82 AFAPIYSWILVLRGLVGFGIGGVPQSVTLYAEFLPMKSRAKCILLIEVFWALGTVFEVLLAVFVMPTLGWRWLLILSALP 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834 212 GIILIMAFKFIPESARFnvstgntqaalntlesiakmnrsvmpegqlvepilekrgrfadlldskylRTTLQIWIIWLGI 291
Cdd:cd17441 162 LLIFAVLCFWLPESARY--------------------------------------------------WTTILLWFIWFSN 191

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 74205834 292 SFAYYGVILASAELLERDLVCGSKSESEPevvettgdsgEGLSPCYCHIFAPSDYRTMIISTLGE 356
Cdd:cd17441 192 AFSYYGLVLLTTELFQAGDVCSGSSGKKV----------EGKCSLECEYLTTSDYMDLLWTTLSE 246
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 51-222 3.73e-29

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 115.78  E-value: 3.73e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834  51 FLIMGSTGVVEAMEIMLIAVVSPVIRCE--WQLENWQVAFVTTMVFFGYMVSSILFGLLADRYGRWKILLLSFLWGAYFS 128
Cdd:cd17316   1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEfsLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834 129 LLTSFSPSYIWFVFLRTMVGCGVSGHAQG-LIIKTEFLPTKYRGYMLPLSQVFWLAGSLLIISMASVVIP----TIGWRW 203
Cdd:cd17316  81 LLIGLLPTPILLLVLRFLQGIGIGGEYPGaSTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPllsgDWGWRI 160

                       170
                ....*....|....*....
gi 74205834 204 LIRIASIPGIILIMAFKFI 222
Cdd:cd17316 161 LFLIGALPALLALLLRRRT 179
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 34-299 3.27e-28

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 113.99  E-value: 3.27e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834    34 VEDAVETIGFGRFHIALFLIMGSTGVVEAMEIMLIAVVSPVIRCEWQLENWQVAFVTTMVFFGYMVSSILFGLLADRYGR 113
Cdd:TIGR00895   2 VQNNIRKQPLSRYQWRAIILSFLIMLMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGR 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834   114 WKILLLSFLWGAYFSLLTSFSPSYIWFVFLRTMVGCGVSG-HAQGLIIKTEFLPTKYRGYMLPLSQVFWLAGSLLIISMA 192
Cdd:TIGR00895  82 RRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGlMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLA 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834   193 SVVIPTIGWRWLIRIASI-PGIILIMAFKFIPESARFNVSTGNTQAALNTLESIAKMNR---SVMPEGQLVEPIleKRGR 268
Cdd:TIGR00895 162 GWLIPVFGWRSLFYVGGIaPLLLLLLLMRFLPESIDFLVSKRPETVRRIVNAIAPQMQAeaqSALPEQKSTQGT--KRSV 239

                         250       260       270
                  ....*....|....*....|....*....|.
gi 74205834   269 FADLLDSKYLRTTLQIWIIWLGISFAYYGVI 299
Cdd:TIGR00895 240 FKALFQGKTARITVLLWLLYFMLLVGVYFLT 270
synapt_SV2 TIGR01299
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ...
 35-298 7.74e-28

synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.


Pssm-ID: 130366 [Multi-domain]  Cd Length: 742  Bit Score: 115.07  E-value: 7.74e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834    35 EDAVETIGFGRFHIALFLIMGSTGVVEAMEIMLIAVVSPVIRCEWQLENWQVAFVTTMVFFGYMVSSILFGLLADRYGRW 114
Cdd:TIGR01299 153 ELIIQECGHGRFQWALFFVLGLALMADGVEVFVVGFVLPSAEKDLCIPDSGKGMLGLIVYLGMMVGAFFWGGLADKLGRK 232

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834   115 KILLLSFLWGAYFSLLTSFSPSYIWFVFLRTMVGCGVSGHAQGLIIK-TEFLPTKYRGYMLPLSQVFWLAGSLLIISMAS 193
Cdd:TIGR01299 233 QCLLICLSVNGFFAFFSSFVQGYGFFLFCRLLSGFGIGGAIPIVFSYfAEFLAQEKRGEHLSWLCMFWMIGGIYAAAMAW 312

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834   194 VVIPTIG-------------WRWLIRIASIPGIILIMAFKFIPESARFNVSTGNTQAALNTLESIAKMN----------- 249
Cdd:TIGR01299 313 AIIPHYGwsfqmgsayqfhsWRVFVIVCAFPCVFAIGALTFMPESPRFFLENGKHDEAWMILKLIHDTNmrakghpekvf 392

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 74205834   250 -----RSVMPEGQLVE------------------PILEKRGRFADLLDSKYLRTTLQIWIIWLGISFAYYGV 298
Cdd:TIGR01299 393 svnhiKTIHQEDELIEiesdtgtwyqrcfvralsEGGGIWGNFLRCFNPEVREITIKLMGVWFTLSFGYYGL 464
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 59-299 3.46e-25

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 105.46  E-value: 3.46e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834  59 VVEAMEIMLIAVVSPVIRCEWQLENWQVAFVTTMVFFGYMVSSILFGLLADRYGRWKILLLSFLWGAYFSLLTSFSPSYI 138
Cdd:cd17371   9 ALDGFDLLLLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYW 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834 139 WFVFLRTMVGCGVSGH-AQGLIIKTEFLPTKYRGYMLPLSQVFWLAGSLLIISMASVVIP----TIGWRWLIRIASIPGI 213
Cdd:cd17371  89 QLLILRALAGLGFGGEwAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLFPllppEIAWRVLFLLGALPAL 168

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834 214 ILIMAFKFIPESARFNVStgntQAALNTLESIAKmnrsvmpegqlvepilekrgrFADLLDSKYLRTTLQIWIIWLGISF 293
Cdd:cd17371 169 LVLFIRRFVKEPPQWQAA----RAARRHFADRPS---------------------LRELFSPPLLRTTLLASLLATGALG 223


                ....*.
gi 74205834 294 AYYGVI 299
Cdd:cd17371 224 GYYGIT 229
MFS_SV2B cd17438
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ...
 51-298 2.52e-24

Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340996 [Multi-domain]  Cd Length: 477  Bit Score: 103.85  E-value: 2.52e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834  51 FLIMGSTGVVEAMEIMLIAVVSPVIRCEWQLENWQVAFVTTMVFFGYMVSSILFGLLADRYGRWKILLLSFLWGAYFSLL 130
Cdd:cd17438   1 FFVLGLALMADGVEVFVVGFVLPSAEKDMCLSSSNKGMLGLIVYLGMMAGAFIWGGLADKLGRKRCLIISLAINASFAFL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834 131 TSFSPSYIWFVFLRTMVGCGVSGHAQGLIIK-TEFLPTKYRGYMLPLSQVFWLAGSLLIISMASVVIPTIG--------- 200
Cdd:cd17438  81 SSFVQGYGAFLFCRLISGFGIGGSLPIVFAYfSEFLAREKRGEHLSWLCMFWMIGGLYASAMAWSIIPHYGwgfsmgtny 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834 201 ----WRWLIRIASIPGIILIMAFKFIPESARFNVSTGNTQAALNTLESIAKMNRSVMPEGQLVEPILE-KRgrfadllds 275
Cdd:cd17438 161 hfhsWRVFVIICALPCIASIIALKFMPESPRFLLEMGKHDEAWMILKNIHDTNMRAKGTPEKVFTVSNiKR--------- 231

                       250       260
                ....*....|....*....|...
gi 74205834 276 kylRTTLQIWIIWLGISFAYYGV 298
Cdd:cd17438 232 ---KNTLFLAVVWFTMAFSYYGL 251
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
44-216 3.19e-23

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 99.17  E-value: 3.19e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834  44 GRFHIALFLIMGSTGVVEAMEIMLIAVVSPVIRCEWQLENWQVAFVTTMVFFGYMVSSILFGLLADRYGRWKILLLSFLW 123
Cdd:COG2271   5 SRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLL 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834 124 GAYFSLLTSFSPSYIWFVFLRTMVGCGVSG-HAQGLIIKTEFLPTKYRGYMLPLSQVFWLAGSLLIISMASVVIPTIGWR 202
Cdd:COG2271  85 WGLATLLFGFATSFWQLLLLRFLLGLGEAGfFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWR 164

                       170
                ....*....|....
gi 74205834 203 WLIRIASIPGIILI 216
Cdd:COG2271 165 AAFLILGLPGLLLA 178
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
 83-223 4.34e-23

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 98.42  E-value: 4.34e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834  83 NWQVAFVTTMVFFGYMVSSILFGLLADRYGRWKILLLSFLWGAYFSLLTSFSPSYIWFVFLRTMVGCGVSG-HAQGLIIK 161
Cdd:cd17317  24 DWLVALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGiFTVGFVLG 103

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 74205834 162 TEFLPTKYRGYMLPLSQVFWlAGSLLIISMASVVIPTigWRWLIRIASIPGIILIMAFKFIP 223
Cdd:cd17317 104 MEIVGPKYRSFVGILFGLFW-ALGYMLLALLAYLIRD--WRWLQLAISLPGLLFLLLLWWLP 162
MFS_SV2 cd17363
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic ...
 51-298 1.00e-21

Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. The SV2 family belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340921 [Multi-domain]  Cd Length: 474  Bit Score: 96.40  E-value: 1.00e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834  51 FLIMGSTGVVEAMEIMLIAVVSPVIRCEWQLENWQVAFVTTMVFFGYMVSSILFGLLADRYGRWKILLLSFLWGAYFSLL 130
Cdd:cd17363   1 FFVLGLALMADGVEVFVVGFVLPSAEKDMCLSNSNKGMLGLIVYLGMMVGAFVWGGLADKLGRKQCLLIALSVNGVFAFL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834 131 TSFSPSYIWFVFLRTMVGCGVSGHAQGLIIK-TEFLPTKYRGYMLPLSQVFWLAGSLLIISMASVVIPTIG--------- 200
Cdd:cd17363  81 SSFVQGYGFFLFCRLLSGIGIGGSIPIVFSYfAEFLAREKRGEHLSWLCMFWMIGGLYASAMAWAIIPHYGwgfsmgtay 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834 201 ----WRWLIRIASIPGIILIMAFKFIPESARFNVSTGNTQAALNTLESIAKMNRSVMPEGQLVEPILE-KRgrfadllds 275
Cdd:cd17363 161 qfhsWRVFVIVCALPSVASVVALTFMPESPRFLLEVGKHDEAWMILKQVHDTNMRAKGHPERVFTVSHiKR--------- 231

                       250       260
                ....*....|....*....|...
gi 74205834 276 kylRTTLQIWIIWLGISFAYYGV 298
Cdd:cd17363 232 ---MNTLFLAIVWFTMSFSYYGL 251
MFS_SV2A cd17439
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; ...
 51-298 1.12e-21

Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. It is unclear how SV2A is involved in correct SV function, but it has been suggested to either act as a transporter or a regulator of exocytosis by mediating Ca2+ dynamics. SV2A has been identified as the molecular target of the antiepileptic drug levetiracetam (LEV). Its expression is decreased in patients with epilepsy and in epileptic animal models. SV2A belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340997 [Multi-domain]  Cd Length: 478  Bit Score: 96.25  E-value: 1.12e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834  51 FLIMGSTGVVEAMEIMLIAVVSPVIRCEWQLENWQVAFVTTMVFFGYMVSSILFGLLADRYGRWKILLLSFLWGAYFSLL 130
Cdd:cd17439   1 YFVLGLALMADGVEVFVVGFVLPSAEKDMCLSDSNKGMLGLIVYLGMMVGAFLWGGLADRIGRRQCLLISLSVNSVFAFF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834 131 TSFSPSYIWFVFLRTMVGCGVSGHAQGLI-IKTEFLPTKYRGYMLPLSQVFWLAGSLLIISMASVVIPTIG--------- 200
Cdd:cd17439  81 SSFVQGYGTFLFCRLLSGVGIGGSIPIVFsYFSEFLAQEKRGEHLSWLCMFWMIGGIYASAMAWAIIPHYGwsfqmgsay 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834 201 ----WRWLIRIASIPGIILIMAFKFIPESARFNVSTGNTQAALNTLESIAKMNRSVMPEGQLVEPILE-KRgrfadllds 275
Cdd:cd17439 161 qfhsWRVFVLVCAFPSVFAIGALTTMPESPRFFLENGKHDEAWMVLKQVHDTNMRAKGHPERVFSVTHiKR--------- 231

                       250       260
                ....*....|....*....|...
gi 74205834 276 kylRTTLQIWIIWLGISFAYYGV 298
Cdd:cd17439 232 ---RITLMMMAVWFTMSFSYYGL 251
MFS_SV2C cd17440
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; ...
 51-298 1.51e-21

Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2C exhibits enriched expression in several basal ganglia nuclei, and has been found to be involved in normal operation of the basal ganglia network and could be also be involved in system adaptation in basal ganglia pathological conditions. SV2C belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340998 [Multi-domain]  Cd Length: 479  Bit Score: 95.75  E-value: 1.51e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834  51 FLIMGSTGVVEAMEIMLIAVVSPVIRCEWQLENWQVAFVTTMVFFGYMVSSILFGLLADRYGRWKILLLSFLWGAYFSLL 130
Cdd:cd17440   1 FFVLGMALMADGVEVFVVGFVLPSAETDMCIPNSGSGWLGSIVYLGMMVGAFFWGGLADKVGRRQSLLICMSVNGFFAFL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834 131 TSFSPSYIWFVFLRTMVGCGVSGHAQGLIIK-TEFLPTKYRGYMLPLSQVFWLAGSLLIISMASVVIPTIG--------- 200
Cdd:cd17440  81 SSFVQGYGLFLFCRLLSGFGIGGAVPTVFSYfAEVLAREKRGEHLSWLCMFWMIGGIYASAMAWAIIPHYGwsfsmgsay 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834 201 ----WRWLIRIASIPGIILIMAFKFIPESARFNVSTGNTQAALNTLESIAKMNrsvmpegqlvepiLEKRGRFADLLDSK 276
Cdd:cd17440 161 qfhsWRVFVIVCALPCVSSVVALTFMPESPRFLLEVGKHDEAWMILKQIHDTN-------------MRARGQPEKVFTVN 227

                       250       260
                ....*....|....*....|....
gi 74205834 277 YL--RTTLQIWIIWLGISFAYYGV 298
Cdd:cd17440 228 RIkkDNTIKLTIVWLTLSFGYYGL 251
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 44-228 5.61e-21

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 91.80  E-value: 5.61e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834  44 GRFHIALFLIMGSTGVVEAMEIMLIAVVSPVIRCEWQLENWQVAFVTTMVFFGYMVSSILFGLLADRYGRWKILLLSFLW 123
Cdd:COG0477   9 TRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLL 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834 124 GAYFSLLTSFSPSYIWFVFLRTMVGCGVSGH-AQGLIIKTEFLPTKYRGYMLPLSQVFWLAGSLLIISMASVVIPTIGWR 202
Cdd:COG0477  89 FGLASLLCGLAPSPELLIAARALQGIGAGGLmPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWR 168

                       170       180
                ....*....|....*....|....*.
gi 74205834 203 WLIRIASIPGIILIMAFKFIPESARF 228
Cdd:COG0477 169 WIFLINAPLGLLALVLRLRLPESRGL 194
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
45-227 1.53e-20

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 91.57  E-value: 1.53e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834  45 RFHIALFLIMGSTGVVEAMEIMLIAVVSPVIRCEWQLENWQVAFVTTMVFFGYMVSSILFGLLADRYGRWKILLLSFLWG 124
Cdd:COG2814   6 RRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLF 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834 125 AYFSLLTSFSPSYIWFVFLRTMVGCGVSG-HAQGLIIKTEFLPTKYRGYMLPLSQVFWLAGSLLIISMASVVIPTIGWRW 203
Cdd:COG2814  86 ALGSLLCALAPSLWLLLAARFLQGLGAGAlFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRW 165

                       170       180
                ....*....|....*....|....*
gi 74205834 204 LIRIASIPGII-LIMAFKFIPESAR 227
Cdd:COG2814 166 VFLVNAVLALLaLLLLLRLLPESRP 190
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 51-216 8.39e-20

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 89.57  E-value: 8.39e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834  51 FLIMgstgVVEAMEIMLIAVVSPVIRCEWQLENWQVAFVTTMVFFGYMVSSILFGLLADRYGRWKILLLSFLWGAYFSLL 130
Cdd:cd17365   5 FLII----VLDGFDLAVMGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834 131 TSFSPSYIWFVFLRTMVGCGVSGH-AQGLIIKTEFLPTKYRGYMLPLSQVFWLAGSLLIISMASVVIPTIGWRWLIRIAS 209
Cdd:cd17365  81 TAFAQSVLQLALLRFLTGLGLGAAmPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGG 160


                ....*..
gi 74205834 210 IPGIILI 216
Cdd:cd17365 161 VPPLILL 167
MFS_SLC22A1_2_3 cd17379
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ...
 84-223 3.29e-17

Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340937 [Multi-domain]  Cd Length: 340  Bit Score: 81.63  E-value: 3.29e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834  84 WQVAFVTTMVFFGYMVSSILFGLLADRYGRWKILLLSFLWGAYFSLLTSFSPSYIWFVFLRTMVGCGVSGH-AQGLIIKT 162
Cdd:cd17379  33 WKLDLFQSSLNLGFLIGSIVIGYLADRFGRKVCFLISILGNGVSGVLMAFSPNYPWFLIFRFLQGLFGKGGwMTGYVLVT 112

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 74205834 163 EFLPTKYRGYMLPLSQVFWLAGsLLIISMASVVIPTigWRWLIRIASIPGIILIMAFKFIP 223
Cdd:cd17379 113 EFVGSKYRRTVGIVYQMFFTLG-LLILPGIAYFIPH--WRWLQLAVTLPNFLFLLYYWFIP 170
MFS_XylE_like cd17359
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ...
 73-235 1.84e-16

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340917 [Multi-domain]  Cd Length: 383  Bit Score: 79.92  E-value: 1.84e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834  73 PVIRCEWQLENWQVAFVTTMVFFGYMVSSILFGLLADRYGRWKILLLSFLWGAYFSLLTSFSPSYIWFVFLRTMVGCGVs 152
Cdd:cd17359  25 PFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIARIIGGLAV- 103

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834 153 GHAQGLIIK--TEFLPTKYRGYMLPLSQVFWLAGSLLI--------ISMASVVIPTIGWRWLIRIASIPGIILIMAFKFI 222
Cdd:cd17359 104 GGASALVPMyiAEVAPAEIRGRLVSLNQLMIVFGQLLAyivnyliaNAGGADWLGAEGWRWMLGLEAIPAILFLLGMLFI 183

                       170
                ....*....|...
gi 74205834 223 PESARFNVSTGNT 235
Cdd:cd17359 184 PESPRWLVSKGKP 196
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 67-227 5.86e-16

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 78.43  E-value: 5.86e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834  67 LIAVVSPVIRCEWQLENWQVAFVTTMVFFGYMVSSILFGLLADRYGRWKILLLS-FLWGAyFSLLTSFSPSYIWFVFLRT 145
Cdd:cd17328  17 TIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGiLIWSA-ATLLSSFAPNFWQLLLFRA 95

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834 146 MVGCGVSGH---AQGLIikTEFLPTKYRGYMLplsQVFWLA---GSLLIISMASVVI-PTIGWRWLIRIASIPGIIL-IM 217
Cdd:cd17328  96 LVGIGEASYspiAPTII--ADLFPKEKRTRAL---GVFYFAiplGSGLGYVVGGLVAqATGGWRWAFRVTGVLGVLLaIL 170

                       170
                ....*....|
gi 74205834 218 AFKFIPESAR 227
Cdd:cd17328 171 LLLFVREPPR 180
SP TIGR00879
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ...
 83-238 6.37e-15

MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273317 [Multi-domain]  Cd Length: 481  Bit Score: 75.84  E-value: 6.37e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834    83 NWQVAFVTTMVFFGYMVSSILFGLLADRYGRWKILLLS---FLWGAYFSLLTSFSPSYIWFVFLRTMVGCGVsGHAQGLI 159
Cdd:TIGR00879  70 SSLWGLVVSIFLVGGFIGALFAGWLSDRFGRKKSLLIIallFVIGAILMGLAAFALSVEMLIVGRVLLGIGV-GIASALV 148

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834   160 IK--TEFLPTKYRGYMLPLSQVFWLAGSLL---IISMASVVIPTIGWRWLIRIASIPGIILIMAFKFIPESARFNVSTGN 234
Cdd:TIGR00879 149 PMylSEIAPKALRGALTSLYQLAITFGILVaygFGSGKVSLNNTLGWRIPLGLQLIPAGLLFLGLFFLPESPRWLVGKGR 228


                  ....
gi 74205834   235 TQAA 238
Cdd:TIGR00879 229 VEEA 232
MFS_SLC22A7_OAT2 cd17447
Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major ...
 90-223 1.25e-14

Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 7 (SLC22A7), also called organic anion transporter 2 (OAT2) mediates sodium-independent transport of a variety of organic anions including prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha-ketoglutarate. It also plays a role in renal uric acid uptake from blood as a first step of tubular secretion. OAT2 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS)of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341005 [Multi-domain]  Cd Length: 341  Bit Score: 74.00  E-value: 1.25e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834  90 TTMVFFGYMVSSILFGLLADRYGRWKILLLSFLWGAYFSLLTSFSPSYIWFVFLRTMVGCGVSGHA-QGLIIKTEFLPTK 168
Cdd:cd17447  41 ATFFFAGVTMGAVAFGYLSDRFGRKRMLLVAYVLSLVFGLASAFSVSYVMFAITRTLTGFALTGFSiISMVLCVEWVDIE 120

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 74205834 169 YRGYMLPLSQVFWLAGSLLIISMASVViptIGWRWLIRIASIPGIILIMAFKFIP 223
Cdd:cd17447 121 HRTVAGVLISLFWTVGNMLLALVAYLI---RDWRWLILAVTLPCAPGIITWWWVP 172
MFS_OAT cd17374
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ...
 91-223 1.82e-14

Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340932 [Multi-domain]  Cd Length: 341  Bit Score: 73.48  E-value: 1.82e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834  91 TMVFFGYMVSSILFGLLADRYGRWKILLLSFLWGAYFSLLTSFSPSYIWFVFLRTMVGCGVSGHA-QGLIIKTEFLPTKY 169
Cdd:cd17374  42 SIFMAGLLVGALIFGHLSDRFGRKFILLLSLLQLAIFGTCAAFAPTFPVYCVLRFLAGFAVSGISiNTLILGTEWTTPRH 121

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 74205834 170 RGYMLPLSQVFWLAGSLLIISMASVViptIGWRWLIRIASIPGIILIMAFKFIP 223
Cdd:cd17374 122 RALAITLTSCFFSIGQMLLAGLAYAI---RDWRLLQLVVSVPFFLFFLYSWWLP 172
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
45-223 4.78e-14

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 72.58  E-value: 4.78e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834  45 RFHIALFLIMGSTGVVEAMeimlIAVVSPVIRCEWQLENWQVAFVTTMVFFGYMVSSILFGLLADRYGRWKILLLSFLWG 124
Cdd:COG0738   8 RALIAIYLLFFLWGFATAL----WGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLM 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834 125 AYFSLLTSFSPSYIWFVFLRTMVGCG-----VSGHAQGLIiktefLPTKYRGYMLPLSQVFWLAGSLLIISMASVVI--- 196
Cdd:COG0738  84 ALGLLLFALAPSYPLLLLALFLLGLGlglldVAANPYVAA-----LGPETAASRLNLLHAFFSLGALLGPLLGGLLIllg 158

                       170       180
                ....*....|....*....|....*..
gi 74205834 197 PTIGWRWLIRIASIPGIILIMAFKFIP 223
Cdd:COG0738 159 LSLSWHLPYLILAVLLLLLALLFLRSK 185
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
 88-225 6.59e-14

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 72.22  E-value: 6.59e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834  88 FVTTMVFFGYMVSSILFGLLADRYGRWKILLLSFLWGAYFSLLTSFSPSYIWFVFLRTMVG--CGVSGHAQGLIIkTEFL 165
Cdd:cd17315  38 LVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVGRFLLGlgVGLASVLVPLYI-SEIA 116

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 74205834 166 PTKYRGYMLPLSQVFWLAGSLL--IISMASVVIPTIGWRWLIRIASIPGIILIMAFKFIPES 225
Cdd:cd17315 117 PAKIRGALGTLNQLMITFGILLayLLGLALSLSPPGWWRLMFALAAVPALLQLLLMFFLPES 178
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 58-228 8.67e-14

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 72.07  E-value: 8.67e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834  58 GVVEAMEIMLIAVVSPVIRCEWQLENWQVAFVTTMVFFGYMVSSILFGLLADRYGRWKILLLSFLWGAYFSLLTSFSPSY 137
Cdd:cd06174   5 FFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSF 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834 138 IWFVFLRTMVGCGVSG-HAQGLIIKTEFLPTKYRGYMLPLSQVFWLAGSLLIISMASVVI--PTIGWRWLIRIASIPGII 214
Cdd:cd06174  85 WLLLLGRFLLGLGSGLiDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILAssLGFGWRAVFLIAAALALL 164

                       170
                ....*....|....
gi 74205834 215 LIMAFKFIPESARF 228
Cdd:cd06174 165 AAILLLLVVPDPPE 178
MFS_GLUT_Class1_2_like cd17357
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ...
 81-243 1.26e-13

Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340915 [Multi-domain]  Cd Length: 447  Bit Score: 71.91  E-value: 1.26e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834  81 LENWQVAFVTTMVFFGYMVSSILFGLLADRYGRWKILLLS---FLWGAYFSLLTSFSPSYIWFVFLRTMVG--CGVSGHA 155
Cdd:cd17357  46 ELDLLWSLIVSIFFIGGAIGSFISAFLANRFGRKNGLLISnalLVVSSLLMFLSKSAKSPELLIFGRFLVGiaCGLSTGF 125

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834 156 QGLIIkTEFLPTKYRGYMLPLSQVFWLAGSLL--IISMASVVIPTIGWRWLIRIASIPGIILIMAFKFIPESARFNVST- 232
Cdd:cd17357 126 VPMYL-QEISPSELRGALGSLTQIGVTLGILLgqVFGLPSVLGTETLWPYLLFFPGIPALLQLAALPFFPESPKFLLISk 204

                       170
                ....*....|.
gi 74205834 233 GNTQAALNTLE 243
Cdd:cd17357 205 GDEEEAEKSLK 215
MFS_GLUT10_12_Class3_like cd17362
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ...
 85-228 2.00e-13

Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340920 [Multi-domain]  Cd Length: 389  Bit Score: 70.84  E-value: 2.00e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834  85 QVAFVTTMVFFGYMVSSILFGLLADRYGRWKILLLSFLWGAYFSLLTSFSPSYIWFVFLRTMVGCGV--SGHAQGLIIkT 162
Cdd:cd17362  40 QSGLVVSGSLLGALLGSLVAGALIDRLGRRKELILAALLYLVGSLVTGLAPSYPVLLVGRLIYGVGIglAMHAAPVYI-A 118

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 74205834 163 EFLPTKYRGYMLPLSQVFWLAGSLLIISMASVVIPTI-GWRWLIRIASIPGIILIMAFKFIPESARF 228
Cdd:cd17362 119 ETSPSHIRGLLVSLKELFIVLGILLGYVSGYAFADVVgGWRYMYGLAAPPALLLGIGMWFLPPSPRW 185
MFS_SLC22A4_5_OCTN1_2 cd17376
Solute carrier family 22 members 4 and 5 (also called Organic cation/carnitine transporters 1 ...
 75-223 2.28e-13

Solute carrier family 22 members 4 and 5 (also called Organic cation/carnitine transporters 1 and 2) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 22 members 4 (SLC22A4) and 5 (SLC22A5), and similar proteins. SLC22A4 is also called ergothioneine transporter (ETT) or organic cation/carnitine transporter 1 (OCTN1). It is a sodium-ion dependent, low affinity carnitine transporter, and a highly specific transporter for the uptake of ergothioneine (ET), a thiolated derivative of histidine with antioxidant properties. ET is a natural compound produced only by certain fungi and bacteria and must be absorbed from the diet by humans and other vetebrates. SLC22A5, also called organic cation/carnitine transporter 2 (OCTN2), is a sodium-ion dependent, high affinity carnitine transporter involved in the active cellular uptake of carnitine. SLC22A4/5 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340934 [Multi-domain]  Cd Length: 342  Bit Score: 70.57  E-value: 2.28e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834  75 IRCEWQL---ENWQVAFVTTMVFFGYMVSSILFGLLADRYGRWKILLLSFLWGAYFSLLTSFSPSYIWFVFLRTMVGCG- 150
Cdd:cd17376  23 IVTEWNLvceDDWKVPLTTSLFFVGVLLGSFISGQLSDRFGRKKVLFATMAVQTGFSFLQIFSPSWEMFTVLFVIVGMGq 102

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 74205834 151 VSGHAQGLIIKTEFLPTKYRGYMLPLSQVFWLAGSLLIISMASVVIPTigWRWLIRIASIPGIILIMAFKFIP 223
Cdd:cd17376 103 ISNYVVAFVLGTEILGKSVRILFSTLGVCIFYAIGYMLLPLFAYFIRD--WRMLLLALTLPGVLCVPLWWFIP 173
Sugar_tr pfam00083
Sugar (and other) transporter;
85-238 5.77e-13

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 69.61  E-value: 5.77e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834    85 QVAFVTTMVFFGYMVSSILFGLLADRYGRWKILLLSFLWGAYFSLLTSFSPSYIWFVFLrtMVGCGVSGHAQGLIIKT-- 162
Cdd:pfam00083  47 LSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAKGKWSVYQL--IVGRVLVGIGVGGASVLap 124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834   163 ----EFLPTKYRGYMLPLSQVFWLAGSLL-IISMASVVI--PTIGWRWLIRIASIPGIILIMAFKFIPESARFNVSTGNT 235
Cdd:pfam00083 125 myisEIAPKKLRGALGSLYQLAITFGILLaYIFGLGLNKtsNSDGWRIPLGLQLVPALLLIIGLLFLPESPRWLVEKGRL 204


                  ...
gi 74205834   236 QAA 238
Cdd:pfam00083 205 EEA 207
MFS_GLUT6_8_Class3_like cd17358
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...
 85-242 6.82e-13

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340916 [Multi-domain]  Cd Length: 436  Bit Score: 69.53  E-value: 6.82e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834  85 QVAFVTTMVFFGYMVSSILFGLLADRYGRWKILLLSFLWGAYFSLLTSFSPSYIWFVFLRTMVGCGVSGHAQGL-IIKTE 163
Cdd:cd17358  42 QFSWFGSLLTLGALIGALLSGKLADRIGRKRTLLISAIPCILGWLLIAFAKDVWMLYLGRFLAGFGGGAASVVVpVYIAE 121

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 74205834 164 FLPTKYRGYMLPLSQVFWLAGSLLIISMASVViptiGWRWLIRIASIPGIILIMAFKFIPESARFNVSTGNTQAALNTL 242
Cdd:cd17358 122 IAPKNVRGALGSLNQLLVNIGILLGYVLGSFL----PWRTLALIGAIPPVVFLILLFFIPESPRWLAKKGREEEAEKSL 196
MFS_1 pfam07690
Major Facilitator Superfamily;
53-224 7.84e-13

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 68.60  E-value: 7.84e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834    53 IMGSTGVVEAMEIMLIAVVSPVIRCEWQLENWQVAFVTTMVFFGYMVSSILFGLLADRYGRWKILLLSFLWGAYFSLLTS 132
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834   133 FSPSYIWFVFLRTMVGCGVSG-HAQGLIIKTEFLPTKYRGYMLPLSQVFWLAGSLLIISMASVVIPTIGWRWLIRIASIP 211
Cdd:pfam07690  81 FASSLWLLLVLRVLQGLGAGAlFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160

                         170
                  ....*....|...
gi 74205834   212 GIILIMAFKFIPE 224
Cdd:pfam07690 161 SLLAAVLLLLPRP 173
MFS_OCT_plant cd17378
Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of ...
 86-215 1.55e-12

Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of transporters; Plant organic cation/carnitine transporters (OCTs) are sequence-similar to their animal counterparts, which are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. Little is know about plant OCTs. In Arabidopsis, there are six genes belonging to this family that show distinct, organ-specific expression pattern of the individual genes. AtOCT1 has been found to affect root development and carnitine-related responses in Arabidopsis. AtOCT4, 5 and 6 are up-regulated during drought stress, AtOCT3 and 5 during cold stress and AtOCT5 and 6 during salt stress treatments. Plant OCTs belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340936 [Multi-domain]  Cd Length: 342  Bit Score: 67.77  E-value: 1.55e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834  86 VAFVTTMVFFGYMVSSILFGLLAD-RYGRWKILLLSFLWGAYFSLLTSFSPSYIWFVFLRTMVGCGVSGHAQ-GLIIKTE 163
Cdd:cd17378  35 VGLPQSSFFVGCLIGSGVLGHLADsSLGRKNLLFLSCLLMALSGIATAFSPNYWVYAFLRFLTGFGRSGIGTcALVLATE 114

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 74205834 164 FLPTKYRGYMLPLSQVFWLAGSLLIISMASVVIPTigWRWLIRIASIPGIIL 215
Cdd:cd17378 115 PVGPKWRGQVGMSTFFFFVLGFMSLPGIAYLNGSS--WRVLYFWTSIPALIY 164
MFS_SLC22A6_OAT1_like cd17446
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar ...
 85-223 1.75e-11

Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar transporters of the Major Facilitator Superfamily; This subfamily includes solute carrier family 22 member 6 (SLC22A6, also called organic anion transporter 1 or OAT1 or para-aminohippurate (PAH) transporter), SLC22A8 (or OAT3), and SLC22A20 (or OAT6). OAT1 and OAT3 are involved in the renal elimination of endogenous and exogenous organic anions (OAs). They function as OA exchangers, coupling the uptake of OAs against an electrochemical gradient with the efflux of intracellular dicarboxylates. SLC22A20 is an OA transporter that mediates the uptake of estrone sulfate. The OAT1-like subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341004 [Multi-domain]  Cd Length: 339  Bit Score: 64.75  E-value: 1.75e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834  85 QVAFVTTMVffGYMVSSILFGLLADRYGRWKILLLSFLWGAYFSLLTSFSPSYIWFVFLRTMVGCGVSGHA-QGLIIKTE 163
Cdd:cd17446  36 QLAQSIYMA--GVLVGAIVFGGLSDRFGRRPLLIWSYLQMAVSGTCAAFSPSFPIYCVFRFLTGMALSGIVlNSVSLNVE 113

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834 164 FLPTKYRGYMLPLSQVFWLAGSLLIISMASVVIPtigWRWLIRIASIPGIILIMAFKFIP 223
Cdd:cd17446 114 WMPTRVRAVVGTLLGYCYTLGQLILAGVAYAIRD---WRWLQLAVSLPFFIFFLYSWWFP 170
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
46-219 2.13e-11

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 64.52  E-value: 2.13e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834  46 FHIALFLIMGSTGVVeameiMLIAVVSPVIRCEWQLENWQVAFVTTMVFFGYMVSSILFGLLADRYGRWKILLLSFLWGA 125
Cdd:COG2223   7 LLLATLAFFLAFGVW-----YLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLG 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834 126 YFSLLTSFSPSYIWFVFLRTMVGCGVSGH---AQGLIIKteFLPTKYRGYMLPLSQVFWLAGSLLIISMASVVIPTIGWR 202
Cdd:COG2223  82 IGLLLLALAVSYWLLLLLGLLLGIGGGGSfavGIALVSK--WFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWR 159

                       170
                ....*....|....*..
gi 74205834 203 WLIRIASIPGIILIMAF 219
Cdd:COG2223 160 NAFLILGILLLVVAVLA 176
MFS_HMIT_like cd17360
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ...
 80-227 8.09e-10

H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340918 [Multi-domain]  Cd Length: 362  Bit Score: 59.59  E-value: 8.09e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834  80 QLENWQVAFVTTMVFFGYMVSSILFGLLADRYGRWKILLLS---FLWGAyfsLLTSFSPSYIWFVFLRTMVGCGVsGHAQ 156
Cdd:cd17360  31 VLSTGWQELIVSSTVAGAAVGAAIGGWLNDRFGRRPCILLAdalFTIGA---IVMAAAPNKEVLIVGRVLVGLGV-GIAS 106

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 74205834 157 gLIIK---TEFLPTKYRGYMLPLSQVFWLAGSLL--IISMASVVIPtIGWRWLIRIASIPGIILIMAFKFIPESAR 227
Cdd:cd17360 107 -MTVPlyiAEAAPPRIRGRLVTINVLFITGGQFVayVINGAFSYLP-GGWRWMLGLAAVPAVLQFIGLLFLPESPR 180
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 48-227 1.79e-09

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 58.74  E-value: 1.79e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834  48 IALFLIMgstgvveaMEIMLIAVVSPVIRCEWQLENWQVAFVTTMVFFGYMVSSILFGLLADRYGRWKILLLSFLWGAYF 127
Cdd:cd17325   3 LALFLDM--------LGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVS 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834 128 SLLTSFSPSYIWFVFLRTMVGCGVSGH---AQGLIikTEFLPTKYRGYMLPLSQVFWLAGSLLIISMASVVIPTIGWRWL 204
Cdd:cd17325  75 TLLFAFATSYWQLLLARFLQGLASAAVwpaAMALI--ADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAP 152

                       170       180
                ....*....|....*....|....
gi 74205834 205 IRIASIPGII-LIMAFKFIPESAR 227
Cdd:cd17325 153 FLVCAALALLaLVLALLLLPEPRP 176
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 68-223 1.99e-09

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 58.35  E-value: 1.99e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834  68 IAVVSPVIRCEWQLENWQVAFVTTMVFFGYMVSSILFGLLADRYG-RWKILLLSFLWGAyFSLLTSFSPSYIWFVFLRTM 146
Cdd:cd17319  22 ISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGaRKVLAVSMLLWSL-FTALTGFATSLTSLYVLRFL 100

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 74205834 147 VGCGVSGHAQGLI-IKTEFLPTKYRGYMLPLSQVFWLAGSLLIISMASVVIPTIGWRWLIRIASIPGIIL-IMAFKFIP 223
Cdd:cd17319 101 LGVAEAGFFPGAIkALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLaVLWWFYLR 179
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
65-219 2.10e-09

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 58.73  E-value: 2.10e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834  65 IMLIAVVSPVIRCEWQLENWQVAFVTTMVFFGYMVSSILFGLLADRYGRWKILLLSFLWGAYFSLLTSFSPSYIWFVFLR 144
Cdd:COG2807  34 ITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGT 113

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 74205834 145 TMVGCGVsGHAQGL---IIKTEFlPTKyRGYMLPLSQVFWLAGSLLIISMASVVIPTIGWRWLIRIASIPGIILIMAF 219
Cdd:COG2807 114 ALIGAGI-AVGNVLlpgLIKRWF-PDR-VGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLW 188
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 90-224 3.59e-09

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 57.97  E-value: 3.59e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834  90 TTMVFFGYMVSSILFGLLADRYGRWKILLLSFLWGAYFSLLTSFSPSYIWFVFLRTMVGCGVS---GHAQGLIikTEFLP 166
Cdd:cd17323  40 VSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILRFLQGFFGSsplAIGAGTI--ADLFT 117

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 74205834 167 TKYRGYMLPLSQVFWLAGSLLIISMASVVIPTIGWRWLIRIASI-PGIILIMAFKFIPE 224
Cdd:cd17323 118 PEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLAIiSGFCLILIFLFLPI 176
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 11-219 8.70e-09

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 56.43  E-value: 8.70e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834  11 IISLRKLSQAAPEPQQKETKTFTVEDAVETIGFGRFHIALFLIMGSTGVVEAMeimLIAVVSPVIRCEWQLENWQVAFVT 90
Cdd:cd17325 165 VLALLLLPEPRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGA---LEPFLPLYAAELGGLSPAQIGLLF 241

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834  91 TMVFFGYMVSSILFGLLADRYGRWKILLLSFLWGAYFSLLTSFSPSYIWFVFLRTMVGCGVS-GHAQGLIIKTEFLPTKY 169
Cdd:cd17325 242 GAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGlVFPATLALLADIVPPEG 321

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|
gi 74205834 170 RGYMLPLSQVFWLAGSLLIISMASVVIPTIGWRWLIRIASIPGIILIMAF 219
Cdd:cd17325 322 RGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLF 371
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 85-226 1.53e-08

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 55.66  E-value: 1.53e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834  85 QVAFVTTMVFFGYMVSSILFGLLADRYGRWKILLLSFLWGAYFSLLTSFSPSYIWFVFLRTMVGCGVSGhaqGLIIKTEF 164
Cdd:cd17320  35 AVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGAAA---GSVVARAI 111

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 74205834 165 LPTKYRGymLPLSQVFWLAGSLLIISMasVVIPTIG--------WR---WLIRIASIpgIILIMAFKFIPESA 226
Cdd:cd17320 112 VRDLYSG--AELAKIFSLLMMILAIAP--ALAPLLGgllllffgWRaifVFLALLGL--LLLLLVLLFLPETL 178
MFS_SLC22A15 cd17377
Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; ...
 75-223 2.05e-08

Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 15 (SLC22A15) is also called fly-like putative transporter 1 (FLIPT1). It is expressed at the highest levels in the kidney and brain. It is a member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A15 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340935 [Multi-domain]  Cd Length: 353  Bit Score: 55.55  E-value: 2.05e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834  75 IRCEWQL---ENWQVAFVTTMVFFGYMVSSILFGLLADRYGRWKILLLSFLWGAYFSLLTSFSPSYIWFVFLRTMVGCGV 151
Cdd:cd17377  27 IVSEWFLvgnAAYKVSLASSFFFAGVLIGVVSFGQLSDRFGRKPVYLTGLALDILFAYFNALAPSYEFFAVSRFLVGVMN 106

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 74205834 152 SGHAQ-GLIIKTEFLPTKYRGYMLPLSQVFWLAGSLLIISMASVVIPtigWRWLIRIASIPGIILIMAFKFIP 223
Cdd:cd17377 107 GGMSLvAFVLLNECVGKSYWALAGSLGGLFFAVGIAQYALLGYFIRS---WRTLAVVVNLQGTLVFLLSLFIP 176
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
 68-242 3.62e-08

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 54.55  E-value: 3.62e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834  68 IAVVSPVIRCEWQLENWQVAFVTTMVFFGYMVSSILFGLLADRYG-RWKILLLSFLWGAYFsLLTSFSPSYIWFVFLRTM 146
Cdd:cd17475  15 IPALAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGeRRVLAVGLLLMGAAA-LLMALVGSYPVLLVLLFL 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834 147 VGCGVSG--HAQGLIIKTEFlPTKYRGYMLPLSQvfwlAGSLLIISMASVVIPTI----GWRWLIRIASIPGIIL-IMAF 219
Cdd:cd17475  94 VGAGYGSvqPGGGRAIMRWF-PPRERGLAMGIRQ----TGVPLGGALAAALLPPLalhyGWRAAFVVAGLVSILAaVLFW 168

                       170       180
                ....*....|....*....|...
gi 74205834 220 KFIPESARFNVSTGNTQAALNTL 242
Cdd:cd17475 169 LFYREPPAASAATESASTLLRSL 191
MFS_GLUT12_Class3 cd17435
Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of ...
 89-239 4.37e-08

Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 12 (GLUT12) is also called Solute carrier family 2, facilitated glucose transporter member 12 (SLC2A12). It is a facilitative glucose transporter, classified as a Class 3 GLUT, and is expressed in the heart, skeletal muscle, prostate, and small intestine, and is highly upregulated in breast ductal cell carcinoma. It plays a role as a secondary insulin-sensitive glucose transporter in insulin-dependent tissues. The GLUT12 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340993 [Multi-domain]  Cd Length: 376  Bit Score: 54.42  E-value: 4.37e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834  89 VTTMVFFGYMVSSILFGLLADRYGRWKILLLSFLWGAYFSLLTSFSPSYIWFVFLRTMVGCGV--SGHAQGLIIkTEFLP 166
Cdd:cd17435  41 VVSSLLIGALLASLTGGVLIDRYGRRTAIILTSCLLVLGSLLLVCSVSYTVLIVGRIAIGVSIslSSIATCVYI-AEIAP 119

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 74205834 167 TKYRGYMLPLSQVFWLAGSLL--IISMASVVIPTiGWRWLIRIASIPGIILIMAFKFIPESARFNVSTGNTQAAL 239
Cdd:cd17435 120 QHRRGLLVSLNELMIVIGILLayISNYAFANVSN-GWKYMFGLVIPLAALQAIAMYFLPPSPRFLVMKDNMRARL 193
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 63-223 4.80e-08

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 54.12  E-value: 4.80e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834  63 MEIMLIAVVsPVIRCEWQLENWQVAFVTTMVFFGYMVSSILFGLLADRYGRWKILLLSFLWGAYFSLLTSFSPSYIWFVF 142
Cdd:cd17504  11 VETMLSPAL-PTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIA 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834 143 LRTMVGCGVSGHAQGLIIKTEFLPTKyrgyMLPLSQVfWLAGSLLIIS-----MASVVIPTIGWRWLIRIASIPGIILIM 217
Cdd:cd17504  90 GRALQGIGGAVFPLAFALVREEFPPE----RVPVAQG-ILSATFGIGAgiglpLGGWIVQHLGWRWIFWTAAPVAVLLAA 164


                ....*.
gi 74205834 218 AFKFIP 223
Cdd:cd17504 165 LVPLID 170
xylE PRK10077
D-xylose transporter XylE; Provisional
 88-245 6.51e-08

D-xylose transporter XylE; Provisional


Pssm-ID: 182225 [Multi-domain]  Cd Length: 479  Bit Score: 54.31  E-value: 6.51e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834   88 FVTTMVFFGYMVSSILFGLLADRYGRWKIL-------LLSFLWGAY----FSLLTSFSPSYIW-FVFLRTMVGCGVsGHA 155
Cdd:PRK10077  59 FCVASALIGCIIGGALGGYCSNRFGRRDSLkiaavlfFISALGSAWpefgFTSIGPDNTGYVPeFVIYRIIGGIGV-GLA 137

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834  156 QGL--IIKTEFLPTKYRGYMLPLSQVFWLAGSLLII--------SMASVVIPTIGWRWLIRIASIPGIILIMAFKFIPES 225
Cdd:PRK10077 138 SMLspMYIAEIAPAHIRGKLVSFNQFAIIFGQLVVYfvnyfiarSGDASWLNTDGWRYMFASEAIPALLFLMLLYFVPET 217

                        170       180
                 ....*....|....*....|
gi 74205834  226 ARFNVSTGNTQAALNTLESI 245
Cdd:PRK10077 218 PRYLMSRGKQEQAEGILRKI 237
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 52-229 6.73e-08

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 53.71  E-value: 6.73e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834  52 LIMGSTGVVEAMEIMLIAVVSPVIRCEWQLENWQVAFVTTMVFFGYMVSSILFGLLADRYGRWKILLLSFLWGAYFSLLT 131
Cdd:cd17324   2 LALALAAFAIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLA 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834 132 SFSPSYIWFVFLRTMVGCGVSGHAQ-GLIIKTEFLPTKYRGYMLPLSQVFWLAGSLLIISMASVVIPTIGWRWLIRIASI 210
Cdd:cd17324  82 ALAPSFALLLLARALAGLAHGGFWAiAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAV 161

                       170       180
                ....*....|....*....|
gi 74205834 211 PGIILIMAF-KFIPESARFN 229
Cdd:cd17324 162 LALLAALLLwRLLPSLPPKK 181
MFS_SLC22A17 cd17445
Solute carrier family 22, member 17 of the Major Facilitator Superfamily; Solute carrier ...
 78-211 8.50e-08

Solute carrier family 22, member 17 of the Major Facilitator Superfamily; Solute carrier family 22, member 17 (SLC22A17) is also called 24p3 receptor (24p3R), lipocalin-2 receptor, or neutrophil gelatinase-associated lipocalin (NGAL) receptor (NGALR). It functions as a cell surface receptor for lipocalin-2 (LCN2), also called NGAL or 24p3, which plays a key role in iron homeostasis and transport. LCN2 is a secreted protein of the lipocalin family that induces apoptosis in some types of cells and inhibits bacterial growth by sequestration of the iron-laden bacterial siderophore. Over-expressions of NGAL and NGALR have been found to be correlated with unfavorable clinicopathologic features and poor prognosis of patients with hepatocellular carcinoma. SLC22A17 is a member of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341003 [Multi-domain]  Cd Length: 346  Bit Score: 53.24  E-value: 8.50e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834  78 EWQL---ENWQVAFVTTMVFFGYMVSSILFGLLADRYGRWKILLLSFLWGAYFSLLTSFSPSYIWFVFLRTMVGCGVSGH 154
Cdd:cd17445  27 EWDLvcsRYWLVPLEQVCFILGFASGYLCLGYTADRLGRRRTLLLSLTLAVPFGVLVAVAASPSLFMAMRFLLGAALAGV 106

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 74205834 155 AQGL-IIKTEFLPTKYRGYMLPLSQVFWLAGSLLIISMAsvvIPTIGWRWLIRIASIP 211
Cdd:cd17445 107 YLTLyLTRLELCDPPQRLLVAMAGGLTMVGGHFLLLGLA---LGCGSWRVLQGTITAP 161
MFS_SLC17 cd17318
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ...
 94-223 1.23e-07

Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340876 [Multi-domain]  Cd Length: 389  Bit Score: 53.01  E-value: 1.23e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834  94 FFGYMVSSILFGLLADRYGRWKILLLSFLWGAYFSLLTSFSP--SYIWFVFLRTMVGCgvsghAQGLI------IKTEFL 165
Cdd:cd17318  66 FYGYILTQIPGGYLAEKYGAKRVLGYSILITALLTLLTPLAArgGYGALIVLRILQGL-----AQGVTfpamhaLWAKWA 140

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 74205834 166 PTKYRGYMLPLSQVFWLAGSLLIISMASVVIPTIGWRWLIRIASIPGIILIMA-FKFIP 223
Cdd:cd17318 141 PPLERSRLTSIAYSGSQFGTVIAMPLSGFLCESLGWPSIFYIFGGLGLLWCLLwFFLVL 199
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 66-153 1.99e-07

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 52.19  E-value: 1.99e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834  66 MLIAVVSPV---IRCEWQLENWQVAFVTTMVFFGYMVSSILFGLLADRYGRWKILLLSFLWGAYFSLLTSFSPSYIWFVF 142
Cdd:cd17474  13 LGVSIVDPIlpaIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLA 92

                        90
                ....*....|.
gi 74205834 143 LRTMVGCGVSG 153
Cdd:cd17474  93 GRALQGIGAAG 103
MFS_SLC22A31 cd17443
Solute carrier family 22, member 31 of the Major Facilitator Superfamily; Solute carrier ...
 78-216 2.10e-07

Solute carrier family 22, member 31 of the Major Facilitator Superfamily; Solute carrier family 22, member 31 (SLC22A31) is an uncharacterized member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A31 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341001 [Multi-domain]  Cd Length: 343  Bit Score: 52.09  E-value: 2.10e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834  78 EWQL---ENWQVAFVTTMVFFGYMVSSILFGLLADRYGRWKILLLSFLWGAYFSLLTSFSPSYIWFVFLRTMVGCGVSGH 154
Cdd:cd17443  27 EWNLvcdDGWKVPLEKISYLLGWLLGYIILGAGCDRLGRRAAFVLSLVLATLLGVSVALSASPPTFLVLRLLQGGTLAGV 106

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 74205834 155 AQGL-IIKTEFLPTKYRGYMLPLSQVFWLAGSLLIISMASVViptIGWRWLIRIASIPGIILI 216
Cdd:cd17443 107 FLSLyIARLELCDPSHRLMVSMGAGFFSVAGELLLPGLAVLC---RDWRVLQGVGTLPLLLLL 166
MFS_TRI12_like cd06179
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...
 85-227 2.24e-07

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340868 [Multi-domain]  Cd Length: 518  Bit Score: 52.63  E-value: 2.24e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834  85 QVAFVTTMVFFGYMVSSILFGLLADRYGRWKILLLSFLWGAYFSLLTSFSPSYIWFVFLRTMVGCGVSGHAQGLIIKTEF 164
Cdd:cd06179  33 NSTWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAGTAKSVNMLIGGQALIGIGAGTQGLGAAVASEL 112

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834 165 LPTKYRGYMLP----LSQVFWLAGSLLIISMASVVIPtiGWRWLIRIASIPGI---ILIMAFKFIPESAR 227
Cdd:cd06179 113 VPNKYRGLVQGvvnlVASPGSALGPLIAGALVEANAA--GWRWIFYINAIFNAlalILLFFFYHPPPRPQ 180
MFS_PLT cd17437
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The ...
 98-228 2.49e-07

Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The plant Polyol transporter (PLT) subfamily includes PLT1-6 from Arabidopsis thaliana and similar transporters. The best characterized member of the group is Polyol transporter 5, also called Sugar-proton symporter PLT5, which mediates the H+-symport of numerous substrates including linear polyols (such as sorbitol, xylitol, erythritol or glycerol), cyclic polyol myo-inositol, and different hexoses, pentoses (including ribose), tetroses, and sugar alcohols. It functions to transport a wide range of substrates into specific sink tissues in the plant. The PLT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340995 [Multi-domain]  Cd Length: 387  Bit Score: 52.02  E-value: 2.49e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834  98 MVSSILFGLLADRYGR-WKILLLS--FLWGAyfsLLTSFSPSYIWFVFLRTMVGCGVsghAQGLIIK----TEFLPTKYR 170
Cdd:cd17437  46 LVGSLAAGRTSDWIGRrYTIALAAliFFVGA---LLMGVAPNYPVLMVGRFVAGIGV---GFALMIApvytAEVAPASSR 119

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 74205834 171 GYMLPLSQVFWLAGSLL--IISMASVVIPT-IGWRWLIRIASIPGIILIMAFKFIPESARF 228
Cdd:cd17437 120 GFLTSFPEIFINIGILLgyVSNYAFSGLPLhVGWRLMLGVGAVPSLFLAIGVLAMPESPRW 180
MFS_GLUT10_Class3 cd17436
Glucose transporter type 10 (GLUT10), a Class 3 GLUT, of the Major Facilitator Superfamily of ...
 58-226 2.72e-07

Glucose transporter type 10 (GLUT10), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 10 (GLUT10) is also called Solute carrier family 2, facilitated glucose transporter member 10 (SLC2A10). It is classified as a Class 3 GLUT and is a facilitative glucose transporter that exhibits a wide tissue distribution. It is expressed in pancreas, placenta, heart, lung, liver, brain, fat, muscle, and kidney. GLUT10 facilitates the transport of dehydroascorbic acid (DHA), the oxidized form of vitamin C, into mitochondria, and also increases cellular uptake of DHA, which in turn protects cells against oxidative stress. Loss-of-function mutations in SLC2A10 cause arterial tortuosity syndrome (ATS), an autosomal recessive connective tissue disorder characterized by twisting and lengthening of the major arteries, hypermobility of the joints, and laxity of skin. The GLUT10 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340994 [Multi-domain]  Cd Length: 376  Bit Score: 52.11  E-value: 2.72e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834  58 GVVEAMEIMLIAVVSPVIRCEWQLENWQVAFVTTMVFFGYMVSSILFGLLADRYGRWKILLLSFLWGAYFSLLTSFSPSY 137
Cdd:cd17436  10 GLTFGYELGIISGALLQLQTDFSLSCFEQEALVSALLIGALLASLIGGFLIDRHGRRTSILGSNLVLLAGSLILTLAGSF 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834 138 IWFVFLRTMVGCGVSGHAQGL-IIKTEFLPTKYRGYMLPLSQVFWLAGSLLIISMASVVIPTI-GWRWLIRIASIPGIIL 215
Cdd:cd17436  90 FWLVIGRAVVGFAISVSSMACcIYVSEMVTPHQRGLLVSLYEAGITVGILISYALNYFFSNVLtGWRYMFGLAIIPAAIQ 169

                       170
                ....*....|.
gi 74205834 216 IMAFKFIPESA 226
Cdd:cd17436 170 FASILLLPKKP 180
PRK03893 PRK03893
putative sialic acid transporter; Provisional
 67-228 2.93e-07

putative sialic acid transporter; Provisional


Pssm-ID: 179668 [Multi-domain]  Cd Length: 496  Bit Score: 52.01  E-value: 2.93e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834   67 LIAVVSPVIRCEWQLENWQVAFVTTMVFFGYMVSSILFGLLADRYGRWKILLLSFLWGAYFSLLTSFSPSYiWFVFL-RT 145
Cdd:PRK03893  38 LITLVLTEVQGEFGLTTVQAASLISAAFISRWFGGLLLGAMGDRYGRRLAMVISIVLFSVGTLACGFAPGY-WTLFIaRL 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834  146 MVGCGVSG-HAQGLIIKTEFLPTKYR----GYMLPLSQVfwlaGSLLIISMASVVIPTIGWRWLIRIASIPGIILIMAFK 220
Cdd:PRK03893 117 VIGMGMAGeYGSSATYVIESWPKHLRnkasGFLISGFSI----GAVVAAQVYSLVVPVWGWRALFFIGILPIIFALWLRK 192


                 ....*...
gi 74205834  221 FIPESARF 228
Cdd:PRK03893 193 NLPEAEDW 200
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 67-247 3.24e-07

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 51.79  E-value: 3.24e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834  67 LIAVVSPVIRCEWQLENWQVAFVTTMVFFGYMVSSILFGLLADRYGRWKILLLSFLWGAYFSLLTSFSPSYIWFVFLRTM 146
Cdd:cd17478  14 FLPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVAL 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834 147 VGCGVSG-HAQGLIIKTEFLPTKYRGYMlplsQVFWLAGSL------LIISMASVVIPTIGWRWLIRIASIpgIILIMAF 219
Cdd:cd17478  94 AGIGSAAfHPEGARLASQAAGGRRGLAM----SIFSVGGNLgfalgpLIAAALVALFGGLGLLILLIIPGL--AVALLLL 167

                       170       180
                ....*....|....*....|....*...
gi 74205834 220 KFIPESARFNVSTGNTQAALNTLESIAK 247
Cdd:cd17478 168 RLRPLKKPEAKKAAAKSSARSTLKGVWR 195
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 62-248 3.34e-07

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 51.81  E-value: 3.34e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834  62 AMEIMLIAVVSPV---IRCEWQLEN-WQVAFVTTMVFFGYMVSSILFGLLADRYGRWKILLLSFLWGAYFSLLTSFSPSY 137
Cdd:cd17473   9 TLTVMAGAAIAPAlpaIAQHFVPNSeLLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSL 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834 138 IWFVFLRTMVGCGVSG---HAQGLIikTEFLPTKYRGYMLPLSQVFWLAGSLLIISMASVVIpTIGWRWLIRIASIPGII 214
Cdd:cd17473  89 YALLASRALLGIGVAGimtLATALI--GDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALA-EIGWRAPFLVYLLALPV 165

                       170       180       190
                ....*....|....*....|....*....|....
gi 74205834 215 LIMAFKFIPESARFNVSTGNTQAALNTLESIAKM 248
Cdd:cd17473 166 LILVLLFLPEPARKSKSAASPGAATAAALPWKRV 199
MFS_GLUT_Class1 cd17431
Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ...
 96-228 3.74e-07

Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-4 are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT1, also called solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1), displays broad substrate specificity and can transport a wide range of pentoses and hexoses including glucose, galactose, mannose, and glucosamine. It is found in the brain, erythrocytes, and in many fetal tissues. GLUT2 (or SLC2A2) is found in the liver, islet of Langerhans, intestine, and kidney, and is the isoform that likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by beta cells. GLUT3 (or SLC2A3) is found in the brain and can mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and dehydroascorbate. GLUT4 (or SLC2A4) is an insulin-regulated facilitative glucose transporter found in adipose tissues, and in skeletal and cardiac muscle. GLUT14 (or SLC2A14) is an orphan transporter expressed mainly in the testis. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340989 [Multi-domain]  Cd Length: 445  Bit Score: 51.57  E-value: 3.74e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834  96 GYMVSSILFGLLADRYGRWKILLLSFLWGAYFSLLTSFS---PSYIWFVFLRTMVG--CGVSGHAQGLIIkTEFLPTKYR 170
Cdd:cd17431  62 GGMIGSFSVGLFVNRFGRRNSMLYNNLLAFAGAALMGLSklaKSYEMLILGRFIIGlyCGLTTGLVPMYI-GEISPTALR 140

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834 171 GYMLPLSQVFWLAGSLL--IISMASVVIPTIGWRWLIRIASIPGIILIMAFKFIPESARF 228
Cdd:cd17431 141 GALGTLHQLGIVVGILIsqIFGLEFILGTEELWPLLLGFTIVPAILQLALLPFCPESPRY 200
PRK11551 PRK11551
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
 70-243 4.09e-07

putative 3-hydroxyphenylpropionic transporter MhpT; Provisional


Pssm-ID: 236927 [Multi-domain]  Cd Length: 406  Bit Score: 51.50  E-value: 4.09e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834   70 VVSPVIRCEWQLENWQVAFVTTMVFFGYMVSSILFGLLADRYGRWKILLLSFLWGAYFSLLTSFSPSYIWFVFLRTMVGC 149
Cdd:PRK11551  36 VAAPRMAQEFGLDVAQMGWAFSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPSLLVARLLTGV 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834  150 GVSGHAQGLI-IKTEFLPTKYRG----YM---LPLsqvfwlaGSLL--IISMASVVipTIGWRWLIRIASI-PGIILIMA 218
Cdd:PRK11551 116 GLGGALPNLIaLTSEAVGPRLRGtavsLMycgVPF-------GGALasVIGVLAAG--DAAWRHIFYVGGVgPLLLVPLL 186

                        170       180
                 ....*....|....*....|....*
gi 74205834  219 FKFIPESARFNVSTGNTQAALNTLE 243
Cdd:PRK11551 187 MRWLPESRAFAQAAGAGKQRAPVLR 211
MFS_HXT cd17356
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ...
 83-228 5.15e-07

Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340914 [Multi-domain]  Cd Length: 403  Bit Score: 51.10  E-value: 5.15e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834  83 NWQVAFVTTMVFFGYMVSSILFGLLADRYGR-WKILLLSFLW--GAyfsLLTSFSPSYIWFVFL-RTMVGCGVSG-HAQG 157
Cdd:cd17356  44 SSRQGLIVSIVNLGSFFGALISSFLSDRIGRkKSIQIGCVIYiiGA---IIQVAAIGKWYQLIVgRIIAGLGVGFaSVLV 120

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 74205834 158 LIIKTEFLPTKYRGYMLPLSQVFWLAGSLL--IISMA-SVVIPTIGWRWLIRIASIPGIILIMAFKFIPESARF 228
Cdd:cd17356 121 PVYQSEVAPKHIRGTLVSLYQLAITIGILVayCINYGtHKLDGSAQWRIPLGLQIVWGLLLLIGMFFLPESPRW 194
MFS_STP cd17361
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; ...
 89-225 5.48e-07

Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; The plant Sugar transport protein (STP) subfamily includes STP1-STP14; they are also called hexose transporters. They mediate the active uptake of hexoses such as glucose, 3-O-methylglucose, fructose, xylose, mannose, galactose, fucose, 2-deoxyglucose and arabinose, by sugar/hydrogen symport. Several STP family transporters are expressed in a tissue-specific manner, or at specific developmental stages. STP1 is the member with the highest expression level of all members and high expression is detected in photosynthetic tissues, such as leaves and stems, while roots, siliques, and flowers show lower expression levels. It plays a major role in the uptake and response of Arabidopsis seeds and seedlings to sugars. The STP subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340919 [Multi-domain]  Cd Length: 390  Bit Score: 51.10  E-value: 5.48e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834  89 VTTMVFFGYMVSSILFGLLADRYGRWKILLL---SFLWGAyfsLLTSFSPSyIWFVFL-RTMVGCGV--SGHAQGLIIkT 162
Cdd:cd17361  56 FTSSLYLAGLVASLLASYVTRKWGRKPSMLIggvLFLVGA---ALNAAAQN-IAMLIVgRILLGFGVgfGNQAVPLYL-S 130

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 74205834 163 EFLPTKYRGYMLPLSQVFWLAGSLL--IISMASVVIPTIGWRWLIRIASIPGIILIMAFKFIPES 225
Cdd:cd17361 131 EMAPAKLRGALNIGFQLAITIGILIanLINYGTSKIKPNGWRLSLGLAAVPALILLLGSLFLPET 195
MFS_OPA_SLC37 cd17312
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ...
 66-225 1.40e-06

Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340870 [Multi-domain]  Cd Length: 364  Bit Score: 49.58  E-value: 1.40e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834  66 MLIAVVSPVIRCEWQLENWQVAFVTTMVFFGYMVSSILFGLLADRYGRWKILLLSFLWGAYFSLLTSFSPSYIWFVFLRt 145
Cdd:cd17312  20 KNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLW- 98

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834 146 mvgcGVSGHAQGL------IIKTEFLPTKYRGYMLPLSQVFWLAGSLLIISMASVVIPTIGWRWLIRIASIPGIIL-IMA 218
Cdd:cd17312  99 ----GLNGLFQSMgwppcvKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLVPGIVGLVVaIIL 174


                ....*..
gi 74205834 219 FKFIPES 225
Cdd:cd17312 175 FFFLRDS 181
MFS_GLUT8_Class3 cd17433
Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of ...
 80-242 4.09e-06

Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 8 (GLUT8) is also called Solute carrier family 2, facilitated glucose transporter member 8 (SLC2A8) or glucose transporter type X1 (GLUTX1). It is classified as a Class 3 GLUT protein and is an insulin-regulated facilitative glucose transporter predominantly expressed in testis and brain. It can also transport fructose and galactose. SLC2A8 knockout mice were viable, developed normally, and display only a very mild phenotype, including mild alterations in the brain (increased proliferation of hippocampal neurons), heart (impaired transmission of electrical wave through the atrium), and sperm cells (reduced number of motile sperm cells). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340991 [Multi-domain]  Cd Length: 416  Bit Score: 48.33  E-value: 4.09e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834  80 QLENWQVAFVTTMVFFGYMVSSILFGLLADRYGR-WKILLLSFLWGAYFSLLTSFSPSYIWFV-FLRTMVGCGVSGHAQG 157
Cdd:cd17433  37 RLDDAAASWFGSVVTLGAAAGGVLGGWIVDRAGRkLSLMLCSVPFIAGFTVITAAQNVWMLYVgRLLTGLASGVTSLVVP 116

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834 158 LIIkTEFLPTKYRGYMLPLSQVFWLAGslliISMASVVIPTIGWRWLIRIASIPGIILIMAFKFIPESARFNVSTGNTQA 237
Cdd:cd17433 117 VYI-SEIAHPRVRGTLGSCVQLMVVIG----IMGAYLAGLVLDWRWLAVLGSIPPTLMLLLMCFMPETPRFLLTQHRRQE 191


                ....*
gi 74205834 238 ALNTL 242
Cdd:cd17433 192 AMAAL 196
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
22-200 5.48e-06

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 47.95  E-value: 5.48e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834  22 PEPQQKETKTFTVEDAVETIGFGRFHIALFLIMGSTGvveaMEIMLIAVVSPVIRCEWQLENWQVAFVTTMVFFGYMVSS 101
Cdd:COG2223 183 PPAGAAAAAKASLRDQLEALRDPRFWLLSLLYFGTFG----SFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGR 258

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834 102 ILFGLLADRYGRWKILLLSFLWGAYFSLLTSFSPSYIWFVFLRTMVGCGVSGHAQGLIIKT--EFLPTKYRGYMLPLSQV 179
Cdd:COG2223 259 PLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGAVFALvpDIFPTKNAGAVYGLVGA 338

                       170       180
                ....*....|....*....|.
gi 74205834 180 FWLAGSLLIISMASVVIPTIG 200
Cdd:COG2223 339 AGGLGGFLGPLLFGALLDATG 359
PRK12307 PRK12307
MFS transporter;
59-225 6.35e-06

MFS transporter;


Pssm-ID: 237051 [Multi-domain]  Cd Length: 426  Bit Score: 48.00  E-value: 6.35e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834   59 VVEAMEIMLIAVVSPVIRCEWQLENWQVAFVTTMVFFGYMVSSILFGLLADRYGRWKILLLSFLWGAYFSLLTSFSPSYI 138
Cdd:PRK12307  28 VFDGFDFMLIFYIMYLIKADLGLTDMEGAFLATAAFIGRPFGGALFGLLADKFGRKPLMMWSIVAYSVGTGLSGLASGVI 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834  139 WFVFLRTMVGCGVSG-HAQGLIIKTEFLPTKYRGYmlplSQVFWLAGSLLIISMASVVIPTI----GWRWLIRIASIPGI 213
Cdd:PRK12307 108 MLTLSRFIVGMGMAGeYACASTYAVESWPKHLKSK----ASAFLVSGFGIGNIIAAYFMPSFaeayGWRAAFFVGLLPVL 183

                        170
                 ....*....|..
gi 74205834  214 ILIMAFKFIPES 225
Cdd:PRK12307 184 LVIYIRARAPES 195
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 48-204 6.48e-06

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 47.55  E-value: 6.48e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834  48 IALFLIMGstgvveAMEIMLIAVVSPVIRCEWQLENWQVAFVTTMVFFGYMVSSILFGLLADRYGRWKILLLSFLWGAYF 127
Cdd:cd17321   1 LLLAVFLA------ALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLA 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834 128 SLLTSFSPSYIWFVFLRtmVGCGVSGHA---QGLIIKTEFLPTKYRGYMLPLSQVFWLAGSLLIISMASVVIPTIGWRWL 204
Cdd:cd17321  75 SLLCALAPSLAFLIAAR--ALQGIGAAAimpASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWI 152
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
85-227 1.06e-05

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 46.79  E-value: 1.06e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834  85 QVAFVTTMVFFGYMVSSILFGLLADRYGR--WKILLLSFLWGAYFSLLTSFSPSYIWFVFLRTMVGCGVSGhAQGLI--I 160
Cdd:COG2271 217 QAGLLLSLPFLAGIVGSLLGGWLSDRLGRrrKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGG-AFGLLwaL 295

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 74205834 161 KTEFLPTKYRGYMLPLSQVFWLAGSLLIISMASVVIPTIGWRWLIRIASIPGII-LIMAFKFIPESAR 227
Cdd:COG2271 296 AAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLaALLALLLLRETRK 363
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 85-222 1.70e-05

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 46.40  E-value: 1.70e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834  85 QVAFVTTMVFFGYMVSSILFGLLADRYGRWKILLLS---FLWGayfSLLTSFSPSYIWFVFLRTMVGCGVSGHAQG-LII 160
Cdd:cd17502  31 LVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAiviFELG---SLLCGLAPNMTMLIVGRAIQGIGGGGLMSLaFII 107

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 74205834 161 KTEFLPTKYRGYMLPLSQVFWLAGSLLIISMASVVIPTIGWRW---------LIRIASIPGIILIMAFKFI 222
Cdd:cd17502 108 IADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWcfyinlpigGLALALLRTILLSSIFGFL 178
MFS_SLC17A9_like cd17380
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ...
 94-214 1.97e-05

Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340938 [Multi-domain]  Cd Length: 361  Bit Score: 46.01  E-value: 1.97e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834  94 FFGYMVSSILFGLLADRYGRWKILLLSFLWGAYFSLLTSF--SPSYIWFVFLRTMVGCGvsghaQGLIIKTEF------L 165
Cdd:cd17380  44 FWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLLTPLlaYSSLPLLILSRILLGLG-----EGVHFPSMTslfsrwV 118

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 74205834 166 PTKYRGYMLPLSQVFWLAGSLLIISMASVVIPTIGWRWLIRIASIPGII 214
Cdd:cd17380 119 PVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVFYFFGLLGLL 167
MFS_GLUT_Class2 cd17432
Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ...
 88-228 2.05e-05

Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT5, also called Solute carrier family 2, facilitated glucose transporter member 5 (SLC2A5), is a well-established fructose transporter found in the small intestine. GLUT7 (or SLC2A7) is a high-affinity glucose and fructose transporter expressed in the small intestine and colon. GLUT9 (or SLC2A9) transports urate and fructose, and is most strongly expressed in the basolateral membranes of proximal renal tubular cells, liver and placenta. It may play a role in urate reabsorption by proximal tubules. GLUT11 (or SLC2A11) is a facilitative glucose transporter expressed in heart and skeletal muscle. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340990 [Multi-domain]  Cd Length: 452  Bit Score: 46.46  E-value: 2.05e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834  88 FVTTMVFFGYMVSSILFGLLADRYGRWKILLLSFLWGAYFSLLTSFS---PSYIWFVFLRTMVG--CGVSGHAQGLIIkT 162
Cdd:cd17432  54 LTVSIFPLGGLFGSLLVGPLVIRLGRKGTLLLNNIFAIVAAILMGLSkiaKSFEMIIVGRFLVGinAGISLNVVPMYL-G 132

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 74205834 163 EFLPTKYRGYMLPLSQVFWLAGSLL--IISMASVVIPTIGWRWLIRIASIPGIILIMAFKFIPESARF 228
Cdd:cd17432 133 ESAPKNLRGAVGLVPAIFITLGILLgqVLGLRELLGNEEGWPLLLALTGVPALLQLLTLPFFPESPRY 200
MFS_GLUT6_Class3 cd17434
Glucose transporter type 6, a Class 3 GLUT, of the Major Facilitator Superfamily of ...
 93-282 4.63e-05

Glucose transporter type 6, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 6 (GLUT6) is also called Solute carrier family 2, facilitated glucose transporter member 6 (SLC2A6). It is classified as a Class 3 GLUT protein, and is a facilitative glucose transporter that binds cytochalasin B with low affinity. It is found in the brain, spleen, and leucocytes. GLUT6 may function in oxalate secretion. SLC2A6 has been identified as an oxalate nephrolithiasis gene in mice; its deletion causes spontaneous calcium oxalate nephrolithiasis in the setting of hyperoxalaemia, hyperoxaluria, and nephrocalcinosis. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340992 [Multi-domain]  Cd Length: 417  Bit Score: 45.21  E-value: 4.63e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834  93 VFFGYMVSSILFGLLADRYGRWKILLLSFLWGAYFSLLTSFSPSYIwfvflrtmvgcgvsghaqgliikTEFLPTKYRGY 172
Cdd:cd17434  74 IMFSAVPSALGYLLMGSAQGIWMLLLGRFLTGFAGGITAASIPVYV-----------------------SEISHPGVRGA 130

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834 173 MLPLSQVFWLAGSLLIISMAsVVIPtigWRWLIRIASIPGIILIMAFKFIPESARFNVSTGNTQAALNTLESIAKMNRSV 252
Cdd:cd17434 131 LGACPQIMAVFGSLALYALG-LLLP---WRWLAVAGEVPVVIMILLLCFMPNSPRFLISKGKDEKALKALAWLRGPNTDY 206

                       170       180       190
                ....*....|....*....|....*....|...
gi 74205834 253 MPEGQLVEPILEKRG---RFADLLDSKYLRTTL 282
Cdd:cd17434 207 MTEFEQIKDNIRKQSsrlSWAELKTPSYYKPIL 239
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
21-153 5.18e-05

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 44.96  E-value: 5.18e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834  21 APEPQQKETKTFTVEDAVETIGFGRFHIALFLIMGSTGvveameiMLIAVVSPVIRCEWQLENWQVAFVTTMVFFGYMVS 100
Cdd:COG2814 187 ESRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFF-------ALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLG 259

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 74205834 101 SILFGLLADRYGRWKILLLSFLWGAYFSLLTSFSPSYIWFVFLRTMVGCGVSG 153
Cdd:COG2814 260 ALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGL 312
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
 80-219 5.96e-05

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 44.56  E-value: 5.96e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834  80 QLENWQ-VAFVTTmvFFGYMVSSILFGLLADRYGRWKILLLSFLWGAYFSLLTSFSPSYIWFVFLRTMVG--CGVSGHAQ 156
Cdd:cd17391  33 LVELWSgLAFSST--FLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVIGLMAFVTNVWQLLILRLLQGvfSGYVPNAT 110

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 74205834 157 GLIIKTefLPTKYRGYMLPLSQVFWLAGSLLIISMASVVIPTIGWRwliRIASIPGIILIMAF 219
Cdd:cd17391 111 ALIASQ--TPKEKSGWALGTLSTGVVAGTLIGPLLGGFLADLFGIR---NVFFITGGLLFLAF 168
MFS_FucP_MFSD4_like cd17333
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...
 62-244 6.06e-05

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340891 [Multi-domain]  Cd Length: 372  Bit Score: 44.62  E-value: 6.06e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834  62 AMEIMLIAVVSPVIRCEWQLENWQVAFVTTMVFFGYMVSSILFGLLADRYGRWKILLLSFLWGAYFSLLTSFSPSYIWFV 141
Cdd:cd17333   9 GLTDALLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFV 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834 142 FLRTMVGCGVS-GHAQGLIIKTEFLPTKyRGYMLPLSQVFWLAGSLLIISMASVVIPTIGW----RWLIRIASIPGIILI 216
Cdd:cd17333  89 VLMFLAGLGAGiLDTGANTFVGALFEES-SATRLNVLHGFFGLGALIGPLIATSLLTSELSwswaYLIIGLIYLLLAILI 167

                       170       180
                ....*....|....*....|....*...
gi 74205834 217 MAFKFIPESARFNVSTGNTQAALNTLES 244
Cdd:cd17333 168 LLTLFPELPSARNPQQSVGAFSASASRL 195
2A0109 TIGR00887
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the ...
 34-306 8.44e-05

phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the major facilitator superfamily (pfam00083). [Transport and binding proteins, Anions]


Pssm-ID: 129965 [Multi-domain]  Cd Length: 502  Bit Score: 44.33  E-value: 8.44e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834    34 VEDAVETIGFGRFHIALFLIMGSTGVVEAMEIMLIAVVSPVI-RCEWQ----LENWQVAFVTTMVFFGYMVSSILFGLLA 108
Cdd:TIGR00887   1 ALEEADTAPFGWQHFRAIVIAGVGFFTDSYDLFCISLVTKMLgYVYYHgkgpLPSSVSAAVNGSASIGTLAGQLFFGWLA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834   109 DRYGRWKILLLSFLWGAYFSLLTSFSPSY------IWFVFLRTMVGCGVSG-HAQGLIIKTEFLPTKYRGYMlpLSQVF- 180
Cdd:TIGR00887  81 DKLGRKRVYGMELIIMIIATVASGLSPGSspksvmATLCFWRFWLGVGIGGdYPLSAIITSEFATKKWRGAM--MAAVFa 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834   181 -----WLAGSLLII-----------------SMASVVIPTIG--WRWLIRIASIPGIILIMAFKFIPESARFNVSTG-NT 235
Cdd:TIGR00887 159 mqgfgILAGAIVALivlagfkhsleaaadeaSCTGSCVPAVDymWRILIGFGAVPALLALYFRLTIPETPRYTADVAkDV 238

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 74205834   236 QAALNTLESIAKMNRSVMPE-----GQLVE-PILEKRGRFADLLDSKYLRTTLQIWIIWLGISFAYYGVILASAELL 306
Cdd:TIGR00887 239 EQAASDMSAVLQVKIEAEPDevekaSTAVEvPKASWSDFFTHFFKWRHGKHLLGTAGSWFLLDIAFYGVNLNQKVIL 315
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 66-150 9.48e-05

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 44.11  E-value: 9.48e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834  66 MLIAVVSPVIRCEWQLEN--WQVAFVTTMVFFGYMVSSILFGLLADRYGRWKILLLSFLWGAYFSLLTSFSPSYIWFVFL 143
Cdd:cd17330  14 IVFPVLPFYVREFNKLGAsgYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLA 93


                ....*..
gi 74205834 144 RTMVGCG 150
Cdd:cd17330  94 RFLDGLT 100
efflux_EmrB TIGR00711
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
 48-224 1.03e-04

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 44.29  E-value: 1.03e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834    48 IALFLIMGSTGVVEAMEIMLIAVVSPVIRCEWQLENWQVAFVTTmvffGYMVSSI----LFGLLADRYGRWKILLLSFLW 123
Cdd:TIGR00711   1 LLLTIVLMLGTFMAVLDSTIVNVAIPTIAGDLGSSLSQVQWVIT----SYMLANAisipLTGWLAKRFGTRRLFLISTFA 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834   124 GAYFSLLTSFSPSYIWFVFLRTMVGCGvsghaQGLIIKTEF--LPTKYRGYMLPLSQVFWLagslLIISMASVVIPTIG- 200
Cdd:TIGR00711  77 FTLGSLLCGVAPNLELMIIFRVIQGFG-----GGPLIPLSFstLLNIYPPEKRGRAMAIWG----LTVLVAPALGPTLGg 147

                         170       180       190
                  ....*....|....*....|....*....|..
gi 74205834   201 -------WRWLIRIASIPGII-LIMAFKFIPE 224
Cdd:TIGR00711 148 wiienyhWRWIFLINVPIGIIvVVVAFFILPR 179
MFS_Amf1_MDR_like cd17476
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ...
 48-203 1.62e-04

Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341029 [Multi-domain]  Cd Length: 362  Bit Score: 43.40  E-value: 1.62e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834  48 IALFL-IMGSTGVVEAMEIMLIAVVSPVIRCEWQLENWQVAFVTTMvffgymvssILFGLLADRYGRWKILLLSFLWGAY 126
Cdd:cd17476   5 GAQLLnQAGLGSVIVILPIIGDSFGTSPNQLSWLAASYSLTVGTFI---------LIFGRLGDIYGHKKMFVIGSFWFAI 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834 127 FSLLTSFSPSYIWFVFLRTMVGCGVSG---HAQGLIIKTeFLPTKYR-------GYMLPLSQVFwlaGSLLiismASVVI 196
Cdd:cd17476  76 WSLIAGFSPNFIFFIICRALQGLGPAFllpNAMALLGRT-YPPGPRKnivfslfGATAPLGFAL---GGVF----GGLFA 147


                ....*..
gi 74205834 197 PTIGWRW 203
Cdd:cd17476 148 QLAWWPW 154
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 85-217 2.45e-04

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 42.59  E-value: 2.45e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834  85 QVAFVTTMVFFGYMVSSILFGLLADRYGRWKILLLSFLWGAYFSLLTSF----SPSYIWFVFLrTMVGCGVSGHAQGLII 160
Cdd:cd17316 214 TSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYllsgSPTLLLLLLF-ILSFFVGGVWGALYAY 292

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 74205834 161 KTEFLPTKYR----GYMLPLSQVFWLAGSLLIISMASVVIPTIGWRWLIRIASIPGIILIM 217
Cdd:cd17316 293 LAELFPTEVRatgvGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVALIVAL 353
MFS_PhT cd17364
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ...
 68-222 3.13e-04

Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340922 [Multi-domain]  Cd Length: 389  Bit Score: 42.26  E-value: 3.13e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834  68 IAVVSPVI-RCEWQLENWQVAFVTTMV----FFGYMVSSILFGLLADRYGRWKILLLSFLWGAYFSLLTSFSPSYI---- 138
Cdd:cd17364  18 ISLVTKILgRLYYGGKGSLPSGVSGLVnaaaLVGTIIGQLFFGFLGDRFGRKRVYGVELIIMIIGTILSALSPGSTplgv 97

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834 139 --WFVFLRTMVGCGVSG-HAQGLIIKTEFLPTKYRGYMLPLSQVFWLAGSLL--IISMASVVI------------PTIGW 201
Cdd:cd17364  98 mgWLIFFRFLLGIGIGGdYPLSATIMSEYANKKRRGALIAAVFAMQGFGILAgaIVTLILSAIfehplpagtyhhADLVW 177

                       170       180
                ....*....|....*....|.
gi 74205834 202 RWLIRIASIPGIILIMAFKFI 222
Cdd:cd17364 178 RIVLGLGAIPALSVLYFRKHL 198
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 63-223 5.32e-04

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 41.79  E-value: 5.32e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834  63 MEIMLIAVVS---PVIRCEWQLENWQVAFVTTmvffGYMVSSILF----GLLADRYGRWKILLLSFLWGAYFSLLTSFSP 135
Cdd:cd17503   7 MAILDTTIVNvalPTIMGDLGASLDTVQWVIT----SYLLALAIMiplsGWLADRFGTRRLFLTALALFTLGSLLCGLAP 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834 136 SYIWFVFLRTMVGCGVsghaqgliikteflptkyrGYMLPLSQVFWLA--------GSLLIISMASVVIPTIG------- 200
Cdd:cd17503  83 NLASLIIFRILQGFGG-------------------GVLIPLAQTILLRiyppekrgAAMGLVGLVILLAPAIGptlggwl 143

                       170       180
                ....*....|....*....|....*...
gi 74205834 201 -----WRWLIRIASIPGIILIMAFKFIP 223
Cdd:cd17503 144 tdnlsWRWIFYINLPIGILALLLAPLLD 171
MFS_SLC22A17_like cd17373
Solute carrier family 22, member 17 and similar proteins of the Major Facilitator Superfamily; ...
 84-225 1.13e-03

Solute carrier family 22, member 17 and similar proteins of the Major Facilitator Superfamily; This group is composed of Solute carrier family 22, members 17, 23, and 31. They are members of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). SLC22A17 functions as a cell surface receptor for lipocalin-2 (LCN2), also called NGAL or 24p3, which plays a key role in iron homeostasis and transport. SLC22A23 and SLC22A31 are orphan members of the SLC22 family. SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22A17-like group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340931 [Multi-domain]  Cd Length: 348  Bit Score: 40.58  E-value: 1.13e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834  84 WQVAFVTTMVFFGYMVSSILFGLLADRYGRWKILLLSFLWGAYFSLLTSFSPSYIWFVFLRTMVGCGVSGHAQGL-IIKT 162
Cdd:cd17373  25 WKVHLEQFSLLLGLIFGYLILGCIADRFGRRPVLLFSLILILIFGLTVALAVSVTMFSTLRFLEGFCLAGIILTLyLLRL 104

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 74205834 163 EFLPTKYRGYMLPLSQVFWLAGSLLIISMASVViptIGWRWLIRIASIPGIILIMAFKFIPES 225
Cdd:cd17373 105 ELCDPGKRLMITMVASLVAVAGQFLMPGLAALC---RDWRVLQALIICPFLLMLLYWSIFPKN 164
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 85-254 2.41e-03

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 39.50  E-value: 2.41e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834  85 QVAFVTTMVFFGYMVSSILFGLLADRYGRWKILLLSFLWGAYFSLLTSFSPSYIWFVFLRTMVGCGVSGHAQGLI-IKTE 163
Cdd:cd17489  32 VAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTAAAtLVAD 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834 164 FLPTKYRGYMLPLSQVFWLAGSLLIISMASVVIPTIGWRWLIRIASIPGIILIMAFKFIPEsarfNVSTGNTQAALNTLE 243
Cdd:cd17489 112 IIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLVFLVKD----PPPVAAEEAEAGTRA 187

                       170
                ....*....|.
gi 74205834 244 SIAKMNRSVMP 254
Cdd:cd17489 188 FRRLVEKKVLP 198
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 97-219 3.03e-03

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 39.45  E-value: 3.03e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834  97 YMVSSILFGLLADRYGRWKILLLSFLWGAYFSLLTSFSPSYIWFVFLRTMVGCGVSGHaQGLI--IKTEFLPTKYRGYML 174
Cdd:cd17370 247 YALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQ-ESIEraAVADLVPAELRGTAY 325

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 74205834 175 PLSQ----VFWLAGSLLiismASVVIPTIGWRWLIRIASIPGIILIMAF 219
Cdd:cd17370 326 GLFNtvvgIGWLLASLI----AGYLWDLISPSAAFLFSAVLALIALLLL 370
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
49-153 4.21e-03

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 39.12  E-value: 4.21e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834  49 ALFLIMGSTGVVEAMEIMLIAVVSPVIRCEWQLENWQVAFVTTMVFFGYMVSSILFGLLADRYGRWKILLLSFLWGAYFS 128
Cdd:COG2211 229 PFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGL 308

                        90       100
                ....*....|....*....|....*..
gi 74205834 129 LLTSFSP--SYIWFVFLRTMVGCGVSG 153
Cdd:COG2211 309 LLLFFLGpgNLWLLLVLAALAGIGLGA 335
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
 86-210 4.75e-03

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 38.78  E-value: 4.75e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834  86 VAFVTTMVF----FGYMVSSILFGLLADRYGRWKILLLSFLWGAYFSLLTSFSPSYIWFVFLRTMVGCGVSG---HAQGL 158
Cdd:cd17391 238 LAFISGLVFsatgVSSLLSAPRLGKLGDRIGHHRILLGALLASALLYIPQAFVQTPWQLGILRFLLGLATGGllpAINSL 317

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 74205834 159 IIKteFLPTKYRGYMLPLSQVFWLAGSLLIISMASVVIPTIGWRWLIRIASI 210
Cdd:cd17391 318 LAK--ITPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIAAHFGYRAVFVVTAL 367
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 85-171 5.63e-03

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 38.49  E-value: 5.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834    85 QVAFVTTMVFFGYMVSSILFGLLADRYGRWKILLLSFLWGAYFSLLTSFSPSYIWFVFLRTMVGCGVSGHAQGLI-IKTE 163
Cdd:TIGR00895 286 LAATGGALFNFGGVIGSIIFGWLADRLGPRVTALLLLLGAVFAVLVGSTLFSPTLLLLLGAIAGFFVNGGQSGLYaLMAL 365


                  ....*...
gi 74205834   164 FLPTKYRG 171
Cdd:TIGR00895 366 FYPTAIRA 373
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 83-143 6.68e-03

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 38.31  E-value: 6.68e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 74205834  83 NWQVAFVTTMVFFGYMVSSILFGLLADRYGRWKILLLSFLWGAYFSLLTSFSPSYIWFVFL 143
Cdd:cd17478 229 LVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGIWSYILL 289
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 85-171 6.69e-03

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 38.34  E-value: 6.69e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834  85 QVAFVTTMVFFGYMVSSILFGLLADRYGRWKILLLSFLWGAYFSLLTSFSP-SYIWFVFLRTMVGCGVSGhAQGLII--K 161
Cdd:cd17365 207 QALTITLLLNIGGVIGSLLLGWLADRFGPKRVLALFFALGAVSLALLGVSPaSLVLLYVLVFLAGACVNG-AQVGLYalA 285

                        90
                ....*....|
gi 74205834 162 TEFLPTKYRG 171
Cdd:cd17365 286 ARFYPTEVRA 295
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
 69-225 7.78e-03

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 38.13  E-value: 7.78e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834    69 AVVSPVIRCEWQLENWQVAFVTTMVFFGYMVSSILFGLLADRYG-RWKILLLSFLWGAyFSLLTSFSPSYIWFVFLRTMV 147
Cdd:TIGR00881  15 ALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNpRVFLPIGLILCAI-VNLFFGFSTSLWVMAALWALN 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74205834   148 GC--GVSGHAQGLIIKTEFLPTKYRGYMLPLSQVFWLAGSLLIISMASVVIPTIGWRWLIRIASIPGIIL-IMAFKFIPE 224
Cdd:TIGR00881  94 GIfqGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAELYSWHWVFIVPGIIAIIVsLICFLLLRD 173


                  .
gi 74205834   225 S 225
Cdd:TIGR00881 174 S 174
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH