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Conserved domains on  [gi|74207875|dbj|BAE29068|]
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unnamed protein product, partial [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Apc1_N pfam19521
Anaphase-promoting complex subunit 1 N-terminal; The anaphase-promoting complex subunit 1 ...
 1-136 6.09e-100

Anaphase-promoting complex subunit 1 N-terminal; The anaphase-promoting complex subunit 1 (Apc1) is the largest scaffolding subunit that constitutes anaphase-promoting complex/cyclosome (APC/C), the crucial RING E3 ubiquitin ligase that controls cell cycle processes like sister chromatid segregation, cytokinesis and the initiation of chromosome replication. This domain represents the Apc1 N-terminal region that is rich in beta-strands and regulatory phosphorylation sites. It contains WD40 repeats and is essential for APC/C catalytic activity as it mediates the coactivator-induced conformational change of the APC/C which promotes UbcH10 binding.


:

Pssm-ID: 437353  Cd Length: 136  Bit Score: 298.03  E-value: 6.09e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74207875     1 MSNFSEERATMIAAGDLQEFVPFGRDHCKHHPNALNLQLRQLQPASELWSSDGAAGLVGSLQEVTIHEKQKESWQLRKGV 80
Cdd:pfam19521   1 MSVVYEERATMIAAGDLQEFVPFGREHCKNHPNALNLQLRQLQPASELWSSDGAAGLVGSLQEVTIHERQKESWQLRKGV 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 74207875    81 SEIGDAADYDEELYVAGNMVIWSKGSKSQALAVYKAFTVDSTVQQALWCDFIISQD 136
Cdd:pfam19521  81 SDVGDEVEYDEELYVAGNMVIWSKGSKTQASAVYKAFTVDSPVQQALWCDFTVPQE 136
ANAPC1 super family cl15124
Anaphase-promoting complex subunit 1 WD40 beta-propeller domain; Apc1 is the largest of the ...
 151-359 1.25e-12

Anaphase-promoting complex subunit 1 WD40 beta-propeller domain; Apc1 is the largest of the subunits of the anaphase-promoting complex or cyclosome. The anaphase-promoting complex is a multiprotein subunit E3 ubiquitin ligase complex that controls segregation of chromosomes and exit from mitosis in eukaryotes. Infection of human fibroblasts with human cytomegalovirus (HCMV) leads to cell cycle dysregulation, which is associated with the inactivation of the anaphase-promoting complex. Apc1 consists of a N-terminal WD40 beta-propeller domain, a middle domain (Mid-N), a PC domain and a C-terminal domain (Mid-C) that coalesces with Mid-N to form Apc1Mid which connects Apc1-WD40 with Apc1-PC and comprises an alpha-solenoid capped by a beta-sandwich. The N-terminal domain is essential for APC/C catalytic activity as it mediates the coactivator-induced conformational change of the APC/C which promotes UbcH10 binding.


The actual alignment was detected with superfamily member pfam12859:

Pssm-ID: 463732  Cd Length: 295  Bit Score: 68.62  E-value: 1.25e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74207875   151 ICILQSSCMNMHSIDGKDYIASLPFQVANVWATKYGLLFERCSSS-HEVPPSLPREP----------------------- 206
Cdd:pfam12859   2 LVVFLKTQAHIYFLSGESHVVPLPFEVESAFPAPRGLLLQRKLEEdERSSLKFPAAPpnsfvssqsspldrsrkslgnpr 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74207875   207 ------------------------LPTMFSMLHPLDEITPLVCKSGSLFGSSRVQ------YVVDPAVKIVF-------- 248
Cdd:pfam12859  82 rssltlsstlgdmwdpppedsdsdLPRLFSLTDPLSELGLVVTSSQSSRSSSPRRdsspqpEFLDPAEEILYvsdldest 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74207875   249 -LNIDPSIVM-TYDAVQNVHSVWTLRRVKPEEENAVLKFPEQA-------GTLQNATTSSSLTAHLRSlSKGESPVASPF 319
Cdd:pfam12859 162 iWTSDPLPLVvTLNRETSQYTIWRAEYLESESESSSSKKRKRSrrrssfmGMATGATTPVARPSNLRE-SFGPLSGKRPR 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 74207875   320 QNYSSIHSQSRSTSSPSLHSRSPSISNMAALSRAHSPALG 359
Cdd:pfam12859 241 SSESHSDEKDEEDLASQLDPDFDDIGVPRRSSRRVSSLLA 280
 
Name Accession Description Interval E-value
Apc1_N pfam19521
Anaphase-promoting complex subunit 1 N-terminal; The anaphase-promoting complex subunit 1 ...
 1-136 6.09e-100

Anaphase-promoting complex subunit 1 N-terminal; The anaphase-promoting complex subunit 1 (Apc1) is the largest scaffolding subunit that constitutes anaphase-promoting complex/cyclosome (APC/C), the crucial RING E3 ubiquitin ligase that controls cell cycle processes like sister chromatid segregation, cytokinesis and the initiation of chromosome replication. This domain represents the Apc1 N-terminal region that is rich in beta-strands and regulatory phosphorylation sites. It contains WD40 repeats and is essential for APC/C catalytic activity as it mediates the coactivator-induced conformational change of the APC/C which promotes UbcH10 binding.


Pssm-ID: 437353  Cd Length: 136  Bit Score: 298.03  E-value: 6.09e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74207875     1 MSNFSEERATMIAAGDLQEFVPFGRDHCKHHPNALNLQLRQLQPASELWSSDGAAGLVGSLQEVTIHEKQKESWQLRKGV 80
Cdd:pfam19521   1 MSVVYEERATMIAAGDLQEFVPFGREHCKNHPNALNLQLRQLQPASELWSSDGAAGLVGSLQEVTIHERQKESWQLRKGV 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 74207875    81 SEIGDAADYDEELYVAGNMVIWSKGSKSQALAVYKAFTVDSTVQQALWCDFIISQD 136
Cdd:pfam19521  81 SDVGDEVEYDEELYVAGNMVIWSKGSKTQASAVYKAFTVDSPVQQALWCDFTVPQE 136
ANAPC1 pfam12859
Anaphase-promoting complex subunit 1 WD40 beta-propeller domain; Apc1 is the largest of the ...
 151-359 1.25e-12

Anaphase-promoting complex subunit 1 WD40 beta-propeller domain; Apc1 is the largest of the subunits of the anaphase-promoting complex or cyclosome. The anaphase-promoting complex is a multiprotein subunit E3 ubiquitin ligase complex that controls segregation of chromosomes and exit from mitosis in eukaryotes. Infection of human fibroblasts with human cytomegalovirus (HCMV) leads to cell cycle dysregulation, which is associated with the inactivation of the anaphase-promoting complex. Apc1 consists of a N-terminal WD40 beta-propeller domain, a middle domain (Mid-N), a PC domain and a C-terminal domain (Mid-C) that coalesces with Mid-N to form Apc1Mid which connects Apc1-WD40 with Apc1-PC and comprises an alpha-solenoid capped by a beta-sandwich. The N-terminal domain is essential for APC/C catalytic activity as it mediates the coactivator-induced conformational change of the APC/C which promotes UbcH10 binding.


Pssm-ID: 463732  Cd Length: 295  Bit Score: 68.62  E-value: 1.25e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74207875   151 ICILQSSCMNMHSIDGKDYIASLPFQVANVWATKYGLLFERCSSS-HEVPPSLPREP----------------------- 206
Cdd:pfam12859   2 LVVFLKTQAHIYFLSGESHVVPLPFEVESAFPAPRGLLLQRKLEEdERSSLKFPAAPpnsfvssqsspldrsrkslgnpr 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74207875   207 ------------------------LPTMFSMLHPLDEITPLVCKSGSLFGSSRVQ------YVVDPAVKIVF-------- 248
Cdd:pfam12859  82 rssltlsstlgdmwdpppedsdsdLPRLFSLTDPLSELGLVVTSSQSSRSSSPRRdsspqpEFLDPAEEILYvsdldest 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74207875   249 -LNIDPSIVM-TYDAVQNVHSVWTLRRVKPEEENAVLKFPEQA-------GTLQNATTSSSLTAHLRSlSKGESPVASPF 319
Cdd:pfam12859 162 iWTSDPLPLVvTLNRETSQYTIWRAEYLESESESSSSKKRKRSrrrssfmGMATGATTPVARPSNLRE-SFGPLSGKRPR 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 74207875   320 QNYSSIHSQSRSTSSPSLHSRSPSISNMAALSRAHSPALG 359
Cdd:pfam12859 241 SSESHSDEKDEEDLASQLDPDFDDIGVPRRSSRRVSSLLA 280
 
Name Accession Description Interval E-value
Apc1_N pfam19521
Anaphase-promoting complex subunit 1 N-terminal; The anaphase-promoting complex subunit 1 ...
 1-136 6.09e-100

Anaphase-promoting complex subunit 1 N-terminal; The anaphase-promoting complex subunit 1 (Apc1) is the largest scaffolding subunit that constitutes anaphase-promoting complex/cyclosome (APC/C), the crucial RING E3 ubiquitin ligase that controls cell cycle processes like sister chromatid segregation, cytokinesis and the initiation of chromosome replication. This domain represents the Apc1 N-terminal region that is rich in beta-strands and regulatory phosphorylation sites. It contains WD40 repeats and is essential for APC/C catalytic activity as it mediates the coactivator-induced conformational change of the APC/C which promotes UbcH10 binding.


Pssm-ID: 437353  Cd Length: 136  Bit Score: 298.03  E-value: 6.09e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74207875     1 MSNFSEERATMIAAGDLQEFVPFGRDHCKHHPNALNLQLRQLQPASELWSSDGAAGLVGSLQEVTIHEKQKESWQLRKGV 80
Cdd:pfam19521   1 MSVVYEERATMIAAGDLQEFVPFGREHCKNHPNALNLQLRQLQPASELWSSDGAAGLVGSLQEVTIHERQKESWQLRKGV 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 74207875    81 SEIGDAADYDEELYVAGNMVIWSKGSKSQALAVYKAFTVDSTVQQALWCDFIISQD 136
Cdd:pfam19521  81 SDVGDEVEYDEELYVAGNMVIWSKGSKTQASAVYKAFTVDSPVQQALWCDFTVPQE 136
ANAPC1 pfam12859
Anaphase-promoting complex subunit 1 WD40 beta-propeller domain; Apc1 is the largest of the ...
 151-359 1.25e-12

Anaphase-promoting complex subunit 1 WD40 beta-propeller domain; Apc1 is the largest of the subunits of the anaphase-promoting complex or cyclosome. The anaphase-promoting complex is a multiprotein subunit E3 ubiquitin ligase complex that controls segregation of chromosomes and exit from mitosis in eukaryotes. Infection of human fibroblasts with human cytomegalovirus (HCMV) leads to cell cycle dysregulation, which is associated with the inactivation of the anaphase-promoting complex. Apc1 consists of a N-terminal WD40 beta-propeller domain, a middle domain (Mid-N), a PC domain and a C-terminal domain (Mid-C) that coalesces with Mid-N to form Apc1Mid which connects Apc1-WD40 with Apc1-PC and comprises an alpha-solenoid capped by a beta-sandwich. The N-terminal domain is essential for APC/C catalytic activity as it mediates the coactivator-induced conformational change of the APC/C which promotes UbcH10 binding.


Pssm-ID: 463732  Cd Length: 295  Bit Score: 68.62  E-value: 1.25e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74207875   151 ICILQSSCMNMHSIDGKDYIASLPFQVANVWATKYGLLFERCSSS-HEVPPSLPREP----------------------- 206
Cdd:pfam12859   2 LVVFLKTQAHIYFLSGESHVVPLPFEVESAFPAPRGLLLQRKLEEdERSSLKFPAAPpnsfvssqsspldrsrkslgnpr 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74207875   207 ------------------------LPTMFSMLHPLDEITPLVCKSGSLFGSSRVQ------YVVDPAVKIVF-------- 248
Cdd:pfam12859  82 rssltlsstlgdmwdpppedsdsdLPRLFSLTDPLSELGLVVTSSQSSRSSSPRRdsspqpEFLDPAEEILYvsdldest 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74207875   249 -LNIDPSIVM-TYDAVQNVHSVWTLRRVKPEEENAVLKFPEQA-------GTLQNATTSSSLTAHLRSlSKGESPVASPF 319
Cdd:pfam12859 162 iWTSDPLPLVvTLNRETSQYTIWRAEYLESESESSSSKKRKRSrrrssfmGMATGATTPVARPSNLRE-SFGPLSGKRPR 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 74207875   320 QNYSSIHSQSRSTSSPSLHSRSPSISNMAALSRAHSPALG 359
Cdd:pfam12859 241 SSESHSDEKDEEDLASQLDPDFDDIGVPRRSSRRVSSLLA 280
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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