|
Name |
Accession |
Description |
Interval |
E-value |
| PHA03247 super family |
cl33720 |
large tegument protein UL36; Provisional |
390-700 |
1.22e-10 |
|
large tegument protein UL36; Provisional
The actual alignment was detected with superfamily member PHA03247:
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 65.34 E-value: 1.22e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74212768 390 PGSMAAFATKNPALQGPQSRLLAEQQGVSYEHLEDNNVSPLTIEDPNIIRDPPSRPDTTPAASSESTEQLPnvqveGPIP 469
Cdd:PHA03247 2569 PPPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPD-----PHPP 2643
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74212768 470 SSRPRKQLPSFDFNGPYLGPPQSHSLPDLPGQLGSPQVGGSlKPALP---GSLEYMCLPPGGQVQLVPLSQVMGQGQAMD 546
Cdd:PHA03247 2644 PTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPR-RRAARptvGSLTSLADPPPPPPTPEPAPHALVSATPLP 2722
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74212768 547 VQCGSSLETTGSPSVEPKENPPVELSVekQEARDNPMTLPISSGGPEGSMMASDYVTPGDPVLTLPTGPLSTSLGPSLGL 626
Cdd:PHA03247 2723 PGPAAARQASPALPAAPAPPAVPAGPA--TPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPS 2800
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 74212768 627 PSAQSPSLCLKLPRVPSGSPALGPPGfedyvELPPSVSQAATSPPGHPAPPVASSPT---VIPGEPREEVGPASPHP 700
Cdd:PHA03247 2801 PWDPADPPAAVLAPAAALPPAASPAG-----PLPPPTSAQPTAPPPPPGPPPPSLPLggsVAPGGDVRRRPPSRSPA 2872
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
245-329 |
5.17e-06 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
:
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 45.57 E-value: 5.17e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74212768 245 NRDSYSLHWETQKIPKYIDHTFQVQYKKKSES-WKDSKTENlGRVNSMDLPQLEPDTSYCARVRVKpisdYDGIWSEWSN 323
Cdd:cd00063 13 TSTSVTLSWTPPEDDGGPITGYVVEYREKGSGdWKEVEVTP-GSETSYTLTGLKPGTEYEFRVRAV----NGGGESPPSE 87
|
....*.
gi 74212768 324 EYTWTT 329
Cdd:cd00063 88 SVTVTT 93
|
|
| FN3 super family |
cl21522 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
137-219 |
8.25e-04 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
The actual alignment was detected with superfamily member pfam09067:
Pssm-ID: 473895 Cd Length: 104 Bit Score: 39.33 E-value: 8.25e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74212768 137 KAQPQNLQCFFDGIQSLHCSWEVWTQTTGSVSFGLFYRPSPAAPEEkCsPVVKEPQASVYTRYRCSLPVPEPSAHSQYTV 216
Cdd:pfam09067 8 PEKPEDIKCFSREKEDFTCFWEEEEDGGLPTTYSFSYAYENETVKE-C-PLYSTSGANSTRLFICFFPKNDVSLFVPLHI 85
|
...
gi 74212768 217 SVK 219
Cdd:pfam09067 86 TVV 88
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
390-700 |
1.22e-10 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 65.34 E-value: 1.22e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74212768 390 PGSMAAFATKNPALQGPQSRLLAEQQGVSYEHLEDNNVSPLTIEDPNIIRDPPSRPDTTPAASSESTEQLPnvqveGPIP 469
Cdd:PHA03247 2569 PPPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPD-----PHPP 2643
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74212768 470 SSRPRKQLPSFDFNGPYLGPPQSHSLPDLPGQLGSPQVGGSlKPALP---GSLEYMCLPPGGQVQLVPLSQVMGQGQAMD 546
Cdd:PHA03247 2644 PTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPR-RRAARptvGSLTSLADPPPPPPTPEPAPHALVSATPLP 2722
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74212768 547 VQCGSSLETTGSPSVEPKENPPVELSVekQEARDNPMTLPISSGGPEGSMMASDYVTPGDPVLTLPTGPLSTSLGPSLGL 626
Cdd:PHA03247 2723 PGPAAARQASPALPAAPAPPAVPAGPA--TPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPS 2800
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 74212768 627 PSAQSPSLCLKLPRVPSGSPALGPPGfedyvELPPSVSQAATSPPGHPAPPVASSPT---VIPGEPREEVGPASPHP 700
Cdd:PHA03247 2801 PWDPADPPAAVLAPAAALPPAASPAG-----PLPPPTSAQPTAPPPPPGPPPPSLPLggsVAPGGDVRRRPPSRSPA 2872
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
441-700 |
4.09e-08 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 57.08 E-value: 4.09e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74212768 441 PPSRPDTT--PAASSESTEQLPNVQVEGPIPSSRPRKQLPSfdfngPYLGPPQSHSLPDLPGQLG----SPQVGGSLKPA 514
Cdd:pfam03154 217 PPNQTQSTaaPHTLIQQTPTLHPQRLPSPHPPLQPMTQPPP-----PSQVSPQPLPQPSLHGQMPpmphSLQTGPSHMQH 291
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74212768 515 LPGSLEYMCLPPGGQVQLVPLSQVMGQGQAMDVQCGSSLETTGSPSVEPKENP--PVELSVEKQEArdnPMTLPISSGGP 592
Cdd:pfam03154 292 PVPPQPFPLTPQSSQSQVPPGPSPAAPGQSQQRIHTPPSQSQLQSQQPPREQPlpPAPLSMPHIKP---PPTTPIPQLPN 368
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74212768 593 EGSMMASDYVTPGDPVLTLPTGPLSTSLGPSLGL-----PSAQSPSLCLKLPRVPSGSPALGPPGFEDYVELPPSVSQAA 667
Cdd:pfam03154 369 PQSHKHPPHLSGPSPFQMNSNLPPPPALKPLSSLsthhpPSAHPPPLQLMPQSQQLPPPPAQPPVLTQSQSLPPPAASHP 448
|
250 260 270
....*....|....*....|....*....|....*
gi 74212768 668 TSPPGHPAPPVASSPT--VIPGEPREEVGPASPHP 700
Cdd:pfam03154 449 PTSGLHQVPSQSPFPQhpFVPGGPPPITPPSGPPT 483
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
245-329 |
5.17e-06 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 45.57 E-value: 5.17e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74212768 245 NRDSYSLHWETQKIPKYIDHTFQVQYKKKSES-WKDSKTENlGRVNSMDLPQLEPDTSYCARVRVKpisdYDGIWSEWSN 323
Cdd:cd00063 13 TSTSVTLSWTPPEDDGGPITGYVVEYREKGSGdWKEVEVTP-GSETSYTLTGLKPGTEYEFRVRAV----NGGGESPPSE 87
|
....*.
gi 74212768 324 EYTWTT 329
Cdd:cd00063 88 SVTVTT 93
|
|
| Interfer-bind |
pfam09294 |
Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary ... |
232-327 |
1.42e-04 |
|
Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary structure consisting of seven beta-strands arranged in an immunoglobulin-like beta-sandwich, in a Greek-key topology. They are required for binding to interferon-alpha.
Pssm-ID: 462746 Cd Length: 103 Bit Score: 41.56 E-value: 1.42e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74212768 232 HIQMEPPILNQTKNrdsyslhWETQKIpkYIDHTFQVQYKKKSESWKdsKTENLGRVNSMDLPQLEPDTSYCarVRVKPI 311
Cdd:pfam09294 18 NVTVKDPETREGKN-------LSLRDL--YGSLQYRVSYWKNSSNGE--KKNTTSTNSFVVLSDLEPGTTYC--VSVQAF 84
|
90
....*....|....*....
gi 74212768 312 SDYD---GIWSEWSNEYTW 327
Cdd:pfam09294 85 SPLDnksSQRSPPQCIRTT 103
|
|
| EpoR_lig-bind |
pfam09067 |
Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin ... |
137-219 |
8.25e-04 |
|
Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin (EPO), with subsequent initiation of the downstream chain of events associated with binding of EPO to the receptor, including EPO-induced erythroblast proliferation and differentiation through induction of the JAK2/STAT5 signaling cascade. The domain adopts a secondary structure composed of a short amino-terminal helix, followed by two beta-sandwich regions.
Pssm-ID: 401127 Cd Length: 104 Bit Score: 39.33 E-value: 8.25e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74212768 137 KAQPQNLQCFFDGIQSLHCSWEVWTQTTGSVSFGLFYRPSPAAPEEkCsPVVKEPQASVYTRYRCSLPVPEPSAHSQYTV 216
Cdd:pfam09067 8 PEKPEDIKCFSREKEDFTCFWEEEEDGGLPTTYSFSYAYENETVKE-C-PLYSTSGANSTRLFICFFPKNDVSLFVPLHI 85
|
...
gi 74212768 217 SVK 219
Cdd:pfam09067 86 TVV 88
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
245-309 |
3.04e-03 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 37.21 E-value: 3.04e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 74212768 245 NRDSYSLHWETQKIP---KYIDHtFQVQYKKKSESWKdsKTENLGRVNSMDLPQLEPDTSYCARVRVK 309
Cdd:smart00060 13 TSTSVTLSWEPPPDDgitGYIVG-YRVEYREEGSEWK--EVNVTPSSTSYTLTGLKPGTEYEFRVRAV 77
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
390-700 |
1.22e-10 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 65.34 E-value: 1.22e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74212768 390 PGSMAAFATKNPALQGPQSRLLAEQQGVSYEHLEDNNVSPLTIEDPNIIRDPPSRPDTTPAASSESTEQLPnvqveGPIP 469
Cdd:PHA03247 2569 PPPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPD-----PHPP 2643
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74212768 470 SSRPRKQLPSFDFNGPYLGPPQSHSLPDLPGQLGSPQVGGSlKPALP---GSLEYMCLPPGGQVQLVPLSQVMGQGQAMD 546
Cdd:PHA03247 2644 PTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPR-RRAARptvGSLTSLADPPPPPPTPEPAPHALVSATPLP 2722
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74212768 547 VQCGSSLETTGSPSVEPKENPPVELSVekQEARDNPMTLPISSGGPEGSMMASDYVTPGDPVLTLPTGPLSTSLGPSLGL 626
Cdd:PHA03247 2723 PGPAAARQASPALPAAPAPPAVPAGPA--TPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPS 2800
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 74212768 627 PSAQSPSLCLKLPRVPSGSPALGPPGfedyvELPPSVSQAATSPPGHPAPPVASSPT---VIPGEPREEVGPASPHP 700
Cdd:PHA03247 2801 PWDPADPPAAVLAPAAALPPAASPAG-----PLPPPTSAQPTAPPPPPGPPPPSLPLggsVAPGGDVRRRPPSRSPA 2872
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
441-700 |
4.09e-08 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 57.08 E-value: 4.09e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74212768 441 PPSRPDTT--PAASSESTEQLPNVQVEGPIPSSRPRKQLPSfdfngPYLGPPQSHSLPDLPGQLG----SPQVGGSLKPA 514
Cdd:pfam03154 217 PPNQTQSTaaPHTLIQQTPTLHPQRLPSPHPPLQPMTQPPP-----PSQVSPQPLPQPSLHGQMPpmphSLQTGPSHMQH 291
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74212768 515 LPGSLEYMCLPPGGQVQLVPLSQVMGQGQAMDVQCGSSLETTGSPSVEPKENP--PVELSVEKQEArdnPMTLPISSGGP 592
Cdd:pfam03154 292 PVPPQPFPLTPQSSQSQVPPGPSPAAPGQSQQRIHTPPSQSQLQSQQPPREQPlpPAPLSMPHIKP---PPTTPIPQLPN 368
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74212768 593 EGSMMASDYVTPGDPVLTLPTGPLSTSLGPSLGL-----PSAQSPSLCLKLPRVPSGSPALGPPGFEDYVELPPSVSQAA 667
Cdd:pfam03154 369 PQSHKHPPHLSGPSPFQMNSNLPPPPALKPLSSLsthhpPSAHPPPLQLMPQSQQLPPPPAQPPVLTQSQSLPPPAASHP 448
|
250 260 270
....*....|....*....|....*....|....*
gi 74212768 668 TSPPGHPAPPVASSPT--VIPGEPREEVGPASPHP 700
Cdd:pfam03154 449 PTSGLHQVPSQSPFPQhpFVPGGPPPITPPSGPPT 483
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
245-329 |
5.17e-06 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 45.57 E-value: 5.17e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74212768 245 NRDSYSLHWETQKIPKYIDHTFQVQYKKKSES-WKDSKTENlGRVNSMDLPQLEPDTSYCARVRVKpisdYDGIWSEWSN 323
Cdd:cd00063 13 TSTSVTLSWTPPEDDGGPITGYVVEYREKGSGdWKEVEVTP-GSETSYTLTGLKPGTEYEFRVRAV----NGGGESPPSE 87
|
....*.
gi 74212768 324 EYTWTT 329
Cdd:cd00063 88 SVTVTT 93
|
|
| Interfer-bind |
pfam09294 |
Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary ... |
232-327 |
1.42e-04 |
|
Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary structure consisting of seven beta-strands arranged in an immunoglobulin-like beta-sandwich, in a Greek-key topology. They are required for binding to interferon-alpha.
Pssm-ID: 462746 Cd Length: 103 Bit Score: 41.56 E-value: 1.42e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74212768 232 HIQMEPPILNQTKNrdsyslhWETQKIpkYIDHTFQVQYKKKSESWKdsKTENLGRVNSMDLPQLEPDTSYCarVRVKPI 311
Cdd:pfam09294 18 NVTVKDPETREGKN-------LSLRDL--YGSLQYRVSYWKNSSNGE--KKNTTSTNSFVVLSDLEPGTTYC--VSVQAF 84
|
90
....*....|....*....
gi 74212768 312 SDYD---GIWSEWSNEYTW 327
Cdd:pfam09294 85 SPLDnksSQRSPPQCIRTT 103
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
389-698 |
1.44e-04 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 45.70 E-value: 1.44e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74212768 389 PPGSMAAFATKNPALQGPQSRLLAEQQGVSyehlednnVSPLTIEDPNIIRDPPSRPDTTPAASSESTEQLPNVQVEGPI 468
Cdd:PHA03247 2691 TVGSLTSLADPPPPPPTPEPAPHALVSATP--------LPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPT 2762
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74212768 469 PSSRPRKQLPSfdfnGPYLGPPQShsLPDLPGQLGSPQVGGSLKPALPGSLEYMCLPPGGQVqlvPLSQVMGQGQAMdvq 548
Cdd:PHA03247 2763 TAGPPAPAPPA----APAAGPPRR--LTRPAVASLSESRESLPSPWDPADPPAAVLAPAAAL---PPAASPAGPLPP--- 2830
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74212768 549 cgsslETTGSPSVEPKENPPVE--LSVEKQEARDNPmtlpISSGGPEGSMMASDYVTPGDPVLTLPTGPLSTSLGPSLGL 626
Cdd:PHA03247 2831 -----PTSAQPTAPPPPPGPPPpsLPLGGSVAPGGD----VRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALP 2901
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74212768 627 PSAQSPSLCLKLPRVPSGSPALGPPGFEDYVELPPSVSQAATSPPGHPAPPVASSPTV--------IPGE---PREEVGP 695
Cdd:PHA03247 2902 PDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVpqpwlgalVPGRvavPRFRVPQ 2981
|
...
gi 74212768 696 ASP 698
Cdd:PHA03247 2982 PAP 2984
|
|
| PRK14959 |
PRK14959 |
DNA polymerase III subunits gamma and tau; Provisional |
503-694 |
1.98e-04 |
|
DNA polymerase III subunits gamma and tau; Provisional
Pssm-ID: 184923 [Multi-domain] Cd Length: 624 Bit Score: 44.67 E-value: 1.98e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74212768 503 GSPQVGGSLKPALpgSLEYMCLPPGGQVQLVPLSQVMGQGQAMDVQCGSSLETTGSPSVEPKENPpvelSVEKQEARDNP 582
Cdd:PRK14959 338 GQRRVLTSLEPAM--ALELLLLNLAMLPRLMPVESLRPSGGGASAPSGSAAEGPASGGAATIPTP----GTQGPQGTAPA 411
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74212768 583 MTLPISSGGPeGSMMASDYVTPGDPVLTLPTGPlstslgPSLGLPSAQSPslclklpRVPSGSPALGPPGfedyvelppS 662
Cdd:PRK14959 412 AGMTPSSAAP-ATPAPSAAPSPRVPWDDAPPAP------PRSGIPPRPAP-------RMPEASPVPGAPD---------S 468
|
170 180 190
....*....|....*....|....*....|..
gi 74212768 663 VSQAATSPPGHPAPPVASSPTviPGEPREEVG 694
Cdd:PRK14959 469 VASASDAPPTLGDPSDTAEHT--PSGPRTWDG 498
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
435-698 |
2.85e-04 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 44.54 E-value: 2.85e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74212768 435 PNIIRDP----PSRPDTTPAASSESTEQLPNVQVEGPIPssrPR--------KQLPSFDFNGPylgppqshsLPDLPGQL 502
Cdd:PHA03247 2492 AGAAPDPggggPPDPDAPPAPSRLAPAILPDEPVGEPVH---PRmltwirglEELASDDAGDP---------PPPLPPAA 2559
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74212768 503 GSPQVGGSLKPALPGSLeymclPPGGQVQL------VPLSQVMGQ--GQAMDVQCGSSLETTGSPSVEPKENPPVELSVE 574
Cdd:PHA03247 2560 PPAAPDRSVPPPRPAPR-----PSEPAVTSrarrpdAPPQSARPRapVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPA 2634
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74212768 575 KQEArDNPMTLPISSGGPEGSMMASDYVTPGDPVLTL--PTGPLSTSLGPSL-GLPSAQSPSLCLKLPRVPSGSPALGPP 651
Cdd:PHA03247 2635 ANEP-DPHPPPTVPPPERPRDDPAPGRVSRPRRARRLgrAAQASSPPQRPRRrAARPTVGSLTSLADPPPPPPTPEPAPH 2713
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 74212768 652 GFEDYVELPPSVSQAATSPPGHP---APPVASSPTVIPGEPREEVGPASP 698
Cdd:PHA03247 2714 ALVSATPLPPGPAAARQASPALPaapAPPAVPAGPATPGGPARPARPPTT 2763
|
|
| PRK10263 |
PRK10263 |
DNA translocase FtsK; Provisional |
556-698 |
4.07e-04 |
|
DNA translocase FtsK; Provisional
Pssm-ID: 236669 [Multi-domain] Cd Length: 1355 Bit Score: 43.92 E-value: 4.07e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74212768 556 TGSPSV--EPKENPPVELSVEKQEARDNPMTLPISSGGPEGSMMASDYVTPGDPVLTLPTGPLSTSLGPSLGLPSAQSPs 633
Cdd:PRK10263 368 TGEPVIapAPEGYPQQSQYAQPAVQYNEPLQQPVQPQQPYYAPAAEQPAQQPYYAPAPEQPAQQPYYAPAPEQPVAGNA- 446
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 74212768 634 lclkLPRVPSGSPALGPPGFEDYVELPPSVSQAatsPPGHPAPPVASSPTVIPGEPREEVGPASP 698
Cdd:PRK10263 447 ----WQAEEQQSTFAPQSTYQTEQTYQQPAAQE---PLYQQPQPVEQQPVVEPEPVVEETKPARP 504
|
|
| EpoR_lig-bind |
pfam09067 |
Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin ... |
137-219 |
8.25e-04 |
|
Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin (EPO), with subsequent initiation of the downstream chain of events associated with binding of EPO to the receptor, including EPO-induced erythroblast proliferation and differentiation through induction of the JAK2/STAT5 signaling cascade. The domain adopts a secondary structure composed of a short amino-terminal helix, followed by two beta-sandwich regions.
Pssm-ID: 401127 Cd Length: 104 Bit Score: 39.33 E-value: 8.25e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74212768 137 KAQPQNLQCFFDGIQSLHCSWEVWTQTTGSVSFGLFYRPSPAAPEEkCsPVVKEPQASVYTRYRCSLPVPEPSAHSQYTV 216
Cdd:pfam09067 8 PEKPEDIKCFSREKEDFTCFWEEEEDGGLPTTYSFSYAYENETVKE-C-PLYSTSGANSTRLFICFFPKNDVSLFVPLHI 85
|
...
gi 74212768 217 SVK 219
Cdd:pfam09067 86 TVV 88
|
|
| IL6Ra-bind |
pfam09240 |
Interleukin-6 receptor alpha chain, binding; Members of this family adopt a structure ... |
142-207 |
1.94e-03 |
|
Interleukin-6 receptor alpha chain, binding; Members of this family adopt a structure consisting of an immunoglobulin-like beta-sandwich, with seven strands in two beta-sheets, in a Greek-key topology. They are required for binding to the cytokine Interleukin-6.
Pssm-ID: 401252 Cd Length: 96 Bit Score: 38.16 E-value: 1.94e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 74212768 142 NLQCFFDGIQSLHCSWEVWTQTTGSVSFGLFYRPSPAAPEEKCSpvvkEPQASVYTRYRCSLPVPE 207
Cdd:pfam09240 1 DLTCFIHNPSNLSCEWKPGPNAPPDTNYVLYVRKSPLGPVLQCQ----YYIRDDGTRIGCQFDDLE 62
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
245-309 |
3.04e-03 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 37.21 E-value: 3.04e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 74212768 245 NRDSYSLHWETQKIP---KYIDHtFQVQYKKKSESWKdsKTENLGRVNSMDLPQLEPDTSYCARVRVK 309
Cdd:smart00060 13 TSTSVTLSWEPPPDDgitGYIVG-YRVEYREEGSEWK--EVNVTPSSTSYTLTGLKPGTEYEFRVRAV 77
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
426-698 |
3.94e-03 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 40.92 E-value: 3.94e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74212768 426 NVSPLTIEDPNIIRDPPSRPDTTPAASSESTEQLPNvQVEGPIPSSRPRKQLPsfdfngpyLGPPQSHSlPDLPGQLGSP 505
Cdd:PHA03307 72 PPGPGTEAPANESRSTPTWSLSTLAPASPAREGSPT-PPGPSSPDPPPPTPPP--------ASPPPSPA-PDLSEMLRPV 141
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74212768 506 QVGGSLKPALPgsleymclPPGGQVQLVPLSQVMGQGQAMDVQcgSSLETTGSPSVEPKENPPVELSVEKQEARDNPMTL 585
Cdd:PHA03307 142 GSPGPPPAASP--------PAAGASPAAVASDAASSRQAALPL--SSPEETARAPSSPPAEPPPSTPPAAASPRPPRRSS 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74212768 586 PISSGGPEGSMM----------------------------ASDYVTPGDPVLTLPT------GPLSTSLGPSLGLPSAQS 631
Cdd:PHA03307 212 PISASASSPAPApgrsaaddagasssdssssessgcgwgpENECPLPRPAPITLPTriweasGWNGPSSRPGPASSSSSP 291
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 74212768 632 PSLCLK-LPRVPSGSPALGPPGFEDYVELPPSVSQAATS--------PPGHPAPPVASSPTviPGEPREEVGPASP 698
Cdd:PHA03307 292 RERSPSpSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSsssessrgAAVSPGPSPSRSPS--PSRPPPPADPSSP 365
|
|
| Pur_ac_phosph_N |
pfam16656 |
Purple acid Phosphatase, N-terminal domain; This domain is found at the N-terminus of Purple ... |
236-329 |
4.08e-03 |
|
Purple acid Phosphatase, N-terminal domain; This domain is found at the N-terminus of Purple acid phosphatase proteins.
Pssm-ID: 465220 [Multi-domain] Cd Length: 93 Bit Score: 37.39 E-value: 4.08e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74212768 236 EPPILNQTKNRDSYSLHWETQKIPKYIdhtfQVQY-KKKSESWKDSKTENL---------GRVNSMDLPQLEPDTSYCAR 305
Cdd:pfam16656 2 EQVHLSLTGDSTSMTVSWVTPSAVTSP----VVQYgTSSSALTSTATATSStyttgdggtGYIHRATLTGLEPGTTYYYR 77
|
90 100
....*....|....*....|....
gi 74212768 306 VRvkpisDYDGIWSEWsneYTWTT 329
Cdd:pfam16656 78 VG-----DDNGGWSEV---YSFTT 93
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
423-699 |
5.04e-03 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 40.54 E-value: 5.04e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74212768 423 EDNNVSPLTIEDPNIIRDPPSRPDTTPAASSESTEQLPNVQVEGPIPSSRPRKQ----LPSFDFNGPYLGPPQSHSLPDL 498
Cdd:PHA03307 29 GDAADDLLSGSQGQLVSDSAELAAVTVVAGAAACDRFEPPTGPPPGPGTEAPANesrsTPTWSLSTLAPASPAREGSPTP 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74212768 499 PGQLGSPQVGGSLKPALPGSLEymclPPGGQVQLVPLSQVMGQGQAMDVQCGSSLETTGSPSVEPKE-NPPVELSVEKQE 577
Cdd:PHA03307 109 PGPSSPDPPPPTPPPASPPPSP----APDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQaALPLSSPEETAR 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74212768 578 ARDNPM-TLPISSGGPEGSmmasdyvtPGDPVLTLPTGPLSTSLGPSLG------LPSAQSPSLCLKLPRVPSGSPALGP 650
Cdd:PHA03307 185 APSSPPaEPPPSTPPAAAS--------PRPPRRSSPISASASSPAPAPGrsaaddAGASSSDSSSSESSGCGWGPENECP 256
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 74212768 651 PGFEDYVELPPSVSQAATSPPGHPAPPVASSPTVIPgEPREEVGPASPH 699
Cdd:PHA03307 257 LPRPAPITLPTRIWEASGWNGPSSRPGPASSSSSPR-ERSPSPSPSSPG 304
|
|
| PRK14971 |
PRK14971 |
DNA polymerase III subunit gamma/tau; |
598-701 |
7.17e-03 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237874 [Multi-domain] Cd Length: 614 Bit Score: 39.76 E-value: 7.17e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74212768 598 ASDYVTPGDPVLTLPTGPLSTSLGPSLGLPSAQSPSlclklPRVPSGSPAlgppgfedyvelPPSVSQAATSPPGHPAPP 677
Cdd:PRK14971 369 ASGGRGPKQHIKPVFTQPAAAPQPSAAAAASPSPSQ-----SSAAAQPSA------------PQSATQPAGTPPTVSVDP 431
|
90 100
....*....|....*....|....
gi 74212768 678 VASSPTVIPGEPREEVGPASPHPE 701
Cdd:PRK14971 432 PAAVPVNPPSTAPQAVRPAQFKEE 455
|
|
| |
