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Conserved domains on  [gi|74207704|dbj|BAE40096|]
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unnamed protein product [Mus musculus]

Protein Classification

WD repeat BOP1/ERB1 family ribosome biogenesis protein( domain architecture ID 12224376)

WD repeat BOP1/ERB1 family ribosome biogenesis protein is a component of a complex that is required for maturation of ribosomal RNAs and formation of the 60S ribosome

CATH:  2.130.10.10
Gene Ontology:  GO:0042254|GO:0003676|GO:0043021|GO:0006364
PubMed:  10322433|30069656|21468892
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BOP1NT smart01035
BOP1NT (NUC169) domain; This N terminal domain is found in BOP1-like WD40 proteins.
 130-388 5.69e-168

BOP1NT (NUC169) domain; This N terminal domain is found in BOP1-like WD40 proteins.


:

Pssm-ID: 214986  Cd Length: 264  Bit Score: 482.98  E-value: 5.69e-168
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74207704    130 YDEFPHVGYDLDGKRIYKPLRTrDELDQFLDKMDDPDFWRTVQDKMTGRDLRLTDEQVALVHRLQRGQFGDSGFNPYEPA 209
Cdd:smart01035   1 YDDYPHIGYDIDGKKIMKPAKG-DALDKFLDSIDDPNFWRTVYDKQTGKDVNLTDEELELIKRIQRGEIPDENYDPYEPY 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74207704    210 VDFFSGDIMIHPVTNRPADKRSFIPSLVEKEKVSRMVHAIKMGWIKPRRP------HDPTPSFYDLWAQEDPNAVLGRHK 283
Cdd:smart01035  80 VEWFTSEVEIMPLSNAPEPKRRFVPSKHEAKKIMKLVHAIRMGWIKPDKPpkekeeEEEYPKFYDLWADEDETETKFRII 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74207704    284 MHVPAPKLALPGHAESYNPPPEYMPTEEERSAWMQQEPVERKLNFLPQKFPSLRTVPAYSRFIQERFERCLDLYLCPRQR 363
Cdd:smart01035 160 MHIPAPKLPLPGHAESYNPPPEYLPTEEEKKEWEELEPEDRKLNFLPQKFDSLRKVPGYTNFIKERFERCLDLYLAPRQR 239

                          250       260
                   ....*....|....*....|....*
gi 74207704    364 KMRVNVDPEDLIPKLPRPRDLQPFP 388
Cdd:smart01035 240 RNKLNIDPESLLPKLPSPKDLRPFP 264
WD40 COG2319
WD40 repeat [General function prediction only];
394-730 1.51e-44

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 165.08  E-value: 1.51e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74207704 394 VYRGHSDLVRCLSVSPGGQWLASGSDDGTLKLWEVATARCMKTV-HVGGVVRSIAWNPNPTIcLVAAAMDDAVLLLNPAl 472
Cdd:COG2319 115 TLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLtGHSGAVTSVAFSPDGKL-LASGSDDGTVRLWDLA- 192

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74207704 473 gdrllvgsTDQLLEAFTPpeepalqparwlevseeehqrglrlricHSKPVTQVTWHGRGDYLAVvlSSQEHTqVLLHQV 552
Cdd:COG2319 193 --------TGKLLRTLTG----------------------------HTGAVRSVAFSPDGKLLAS--GSADGT-VRLWDL 233

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74207704 553 SRRRSQSPFRRSHGQVQCVAFHPSRPFVLVASQ-RSIRIYHLLRQELTKKLMPNCKWVSSMAVHPAGDNIICGSYDSKLV 631
Cdd:COG2319 234 ATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSAdGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVR 313

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74207704 632 WFDLDlSTKPYKVLRHHKKALRAVAFHPRYPLFASGSDDGSVIVChgmvynDLLQNPLLvpvKVLKGHTLtrdlGVLDVA 711
Cdd:COG2319 314 LWDLA-TGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLW------DLATGELL---RTLTGHTG----AVTSVA 379

                       330
                ....*....|....*....
gi 74207704 712 FHPTQPWVFSSGADGTIRL 730
Cdd:COG2319 380 FSPDGRTLASGSADGTVRL 398
 
Name Accession Description Interval E-value
BOP1NT smart01035
BOP1NT (NUC169) domain; This N terminal domain is found in BOP1-like WD40 proteins.
 130-388 5.69e-168

BOP1NT (NUC169) domain; This N terminal domain is found in BOP1-like WD40 proteins.


Pssm-ID: 214986  Cd Length: 264  Bit Score: 482.98  E-value: 5.69e-168
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74207704    130 YDEFPHVGYDLDGKRIYKPLRTrDELDQFLDKMDDPDFWRTVQDKMTGRDLRLTDEQVALVHRLQRGQFGDSGFNPYEPA 209
Cdd:smart01035   1 YDDYPHIGYDIDGKKIMKPAKG-DALDKFLDSIDDPNFWRTVYDKQTGKDVNLTDEELELIKRIQRGEIPDENYDPYEPY 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74207704    210 VDFFSGDIMIHPVTNRPADKRSFIPSLVEKEKVSRMVHAIKMGWIKPRRP------HDPTPSFYDLWAQEDPNAVLGRHK 283
Cdd:smart01035  80 VEWFTSEVEIMPLSNAPEPKRRFVPSKHEAKKIMKLVHAIRMGWIKPDKPpkekeeEEEYPKFYDLWADEDETETKFRII 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74207704    284 MHVPAPKLALPGHAESYNPPPEYMPTEEERSAWMQQEPVERKLNFLPQKFPSLRTVPAYSRFIQERFERCLDLYLCPRQR 363
Cdd:smart01035 160 MHIPAPKLPLPGHAESYNPPPEYLPTEEEKKEWEELEPEDRKLNFLPQKFDSLRKVPGYTNFIKERFERCLDLYLAPRQR 239

                          250       260
                   ....*....|....*....|....*
gi 74207704    364 KMRVNVDPEDLIPKLPRPRDLQPFP 388
Cdd:smart01035 240 RNKLNIDPESLLPKLPSPKDLRPFP 264
BOP1NT pfam08145
BOP1NT (NUC169) domain; This N terminal domain is found in BOP1-like WD40 proteins.
 130-388 1.73e-167

BOP1NT (NUC169) domain; This N terminal domain is found in BOP1-like WD40 proteins.


Pssm-ID: 462371  Cd Length: 259  Bit Score: 481.65  E-value: 1.73e-167
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74207704   130 YDEFPHVGYDLDGKRIYKPlRTRDELDQFLDKMDDPDFWRTVQDKMTGRDLRLTDEQVALVHRLQRGQFGDSGFNPYEPA 209
Cdd:pfam08145   1 YDDYPHIGYDIDGKKIMKP-AKGDALDKFLDSMDDPNAWRTVYDKLTGKDVVLTDEDLELIRRIQKGEFPDAGYDPYEPY 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74207704   210 VDFFSGDIMIHPVTNRPADKRSFIPSLVEKEKVSRMVHAIKMGWIKPRRPHDPTPSFYDLWAQEDPNAVLGRHKM-HVPA 288
Cdd:pfam08145  80 VEWFTSEDEIHPLSNAPEPKRRFIPSKWEAKKVMKLVRAIRMGRIKPRKPKEEEPKFYDLWADEDETEEERRRRPdHIPA 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74207704   289 PKLALPGHAESYNPPPEYMPTEEERSAWMQQEPVERKLNFLPQKFPSLRTVPAYSRFIQERFERCLDLYLCPRQRKMRVN 368
Cdd:pfam08145 160 PKLPLPGHAESYNPPPEYLPTEEERKKWEEMDPEDRKLNFLPQKYDSLRLVPAYEKFIKERFERCLDLYLCPRVRKNRLN 239

                         250       260
                  ....*....|....*....|
gi 74207704   369 VDPEDLIPKLPRPRDLQPFP 388
Cdd:pfam08145 240 IDPESLLPKLPSPKDLRPFP 259
WD40 COG2319
WD40 repeat [General function prediction only];
394-730 1.51e-44

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 165.08  E-value: 1.51e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74207704 394 VYRGHSDLVRCLSVSPGGQWLASGSDDGTLKLWEVATARCMKTV-HVGGVVRSIAWNPNPTIcLVAAAMDDAVLLLNPAl 472
Cdd:COG2319 115 TLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLtGHSGAVTSVAFSPDGKL-LASGSDDGTVRLWDLA- 192

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74207704 473 gdrllvgsTDQLLEAFTPpeepalqparwlevseeehqrglrlricHSKPVTQVTWHGRGDYLAVvlSSQEHTqVLLHQV 552
Cdd:COG2319 193 --------TGKLLRTLTG----------------------------HTGAVRSVAFSPDGKLLAS--GSADGT-VRLWDL 233

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74207704 553 SRRRSQSPFRRSHGQVQCVAFHPSRPFVLVASQ-RSIRIYHLLRQELTKKLMPNCKWVSSMAVHPAGDNIICGSYDSKLV 631
Cdd:COG2319 234 ATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSAdGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVR 313

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74207704 632 WFDLDlSTKPYKVLRHHKKALRAVAFHPRYPLFASGSDDGSVIVChgmvynDLLQNPLLvpvKVLKGHTLtrdlGVLDVA 711
Cdd:COG2319 314 LWDLA-TGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLW------DLATGELL---RTLTGHTG----AVTSVA 379

                       330
                ....*....|....*....
gi 74207704 712 FHPTQPWVFSSGADGTIRL 730
Cdd:COG2319 380 FSPDGRTLASGSADGTVRL 398
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 394-732 4.32e-44

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 160.19  E-value: 4.32e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74207704 394 VYRGHSDLVRCLSVSPGGQWLASGSDDGTLKLWEVATARCMKT--VHVGGVvRSIAWNPNpTICLVAAAMDDAVLLLNPa 471
Cdd:cd00200   4 TLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTlkGHTGPV-RDVAASAD-GTYLASGSSDKTIRLWDL- 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74207704 472 lgdrllvgSTDQLLEAFTppeepalqparwlevseeehqrglrlriCHSKPVTQVTWHGRGDYLAvvlSSQEHTQVLLHQ 551
Cdd:cd00200  81 --------ETGECVRTLT----------------------------GHTSYVSSVAFSPDGRILS---SSSRDKTIKVWD 121

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74207704 552 VSRRRSQSPFRrSH-GQVQCVAFHPSRPFVLVASQ-RSIRIYHLLRQELTKKLMPNCKWVSSMAVHPAGDNIICGSYDSK 629
Cdd:cd00200 122 VETGKCLTTLR-GHtDWVNSVAFSPDGTFVASSSQdGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGT 200

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74207704 630 L-VWfdlDLST-KPYKVLRHHKKALRAVAFHPRYPLFASGSDDGSVIVchgmvYNDLLQnpllVPVKVLKGHTLtrdlGV 707
Cdd:cd00200 201 IkLW---DLSTgKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRV-----WDLRTG----ECVQTLSGHTN----SV 264

                       330       340
                ....*....|....*....|....*
gi 74207704 708 LDVAFHPTQPWVFSSGADGTIRLFS 732
Cdd:cd00200 265 TSLAWSPDGKRLASGSADGTIRIWD 289
WD40 pfam00400
WD domain, G-beta repeat;
394-427 1.11e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 54.27  E-value: 1.11e-09
                          10        20        30
                  ....*....|....*....|....*....|....
gi 74207704   394 VYRGHSDLVRCLSVSPGGQWLASGSDDGTLKLWE 427
Cdd:pfam00400   6 TLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 394-427 1.73e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 53.47  E-value: 1.73e-09
                           10        20        30
                   ....*....|....*....|....*....|....
gi 74207704    394 VYRGHSDLVRCLSVSPGGQWLASGSDDGTLKLWE 427
Cdd:smart00320   7 TLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
 
Name Accession Description Interval E-value
BOP1NT smart01035
BOP1NT (NUC169) domain; This N terminal domain is found in BOP1-like WD40 proteins.
 130-388 5.69e-168

BOP1NT (NUC169) domain; This N terminal domain is found in BOP1-like WD40 proteins.


Pssm-ID: 214986  Cd Length: 264  Bit Score: 482.98  E-value: 5.69e-168
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74207704    130 YDEFPHVGYDLDGKRIYKPLRTrDELDQFLDKMDDPDFWRTVQDKMTGRDLRLTDEQVALVHRLQRGQFGDSGFNPYEPA 209
Cdd:smart01035   1 YDDYPHIGYDIDGKKIMKPAKG-DALDKFLDSIDDPNFWRTVYDKQTGKDVNLTDEELELIKRIQRGEIPDENYDPYEPY 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74207704    210 VDFFSGDIMIHPVTNRPADKRSFIPSLVEKEKVSRMVHAIKMGWIKPRRP------HDPTPSFYDLWAQEDPNAVLGRHK 283
Cdd:smart01035  80 VEWFTSEVEIMPLSNAPEPKRRFVPSKHEAKKIMKLVHAIRMGWIKPDKPpkekeeEEEYPKFYDLWADEDETETKFRII 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74207704    284 MHVPAPKLALPGHAESYNPPPEYMPTEEERSAWMQQEPVERKLNFLPQKFPSLRTVPAYSRFIQERFERCLDLYLCPRQR 363
Cdd:smart01035 160 MHIPAPKLPLPGHAESYNPPPEYLPTEEEKKEWEELEPEDRKLNFLPQKFDSLRKVPGYTNFIKERFERCLDLYLAPRQR 239

                          250       260
                   ....*....|....*....|....*
gi 74207704    364 KMRVNVDPEDLIPKLPRPRDLQPFP 388
Cdd:smart01035 240 RNKLNIDPESLLPKLPSPKDLRPFP 264
BOP1NT pfam08145
BOP1NT (NUC169) domain; This N terminal domain is found in BOP1-like WD40 proteins.
 130-388 1.73e-167

BOP1NT (NUC169) domain; This N terminal domain is found in BOP1-like WD40 proteins.


Pssm-ID: 462371  Cd Length: 259  Bit Score: 481.65  E-value: 1.73e-167
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74207704   130 YDEFPHVGYDLDGKRIYKPlRTRDELDQFLDKMDDPDFWRTVQDKMTGRDLRLTDEQVALVHRLQRGQFGDSGFNPYEPA 209
Cdd:pfam08145   1 YDDYPHIGYDIDGKKIMKP-AKGDALDKFLDSMDDPNAWRTVYDKLTGKDVVLTDEDLELIRRIQKGEFPDAGYDPYEPY 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74207704   210 VDFFSGDIMIHPVTNRPADKRSFIPSLVEKEKVSRMVHAIKMGWIKPRRPHDPTPSFYDLWAQEDPNAVLGRHKM-HVPA 288
Cdd:pfam08145  80 VEWFTSEDEIHPLSNAPEPKRRFIPSKWEAKKVMKLVRAIRMGRIKPRKPKEEEPKFYDLWADEDETEEERRRRPdHIPA 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74207704   289 PKLALPGHAESYNPPPEYMPTEEERSAWMQQEPVERKLNFLPQKFPSLRTVPAYSRFIQERFERCLDLYLCPRQRKMRVN 368
Cdd:pfam08145 160 PKLPLPGHAESYNPPPEYLPTEEERKKWEEMDPEDRKLNFLPQKYDSLRLVPAYEKFIKERFERCLDLYLCPRVRKNRLN 239

                         250       260
                  ....*....|....*....|
gi 74207704   369 VDPEDLIPKLPRPRDLQPFP 388
Cdd:pfam08145 240 IDPESLLPKLPSPKDLRPFP 259
WD40 COG2319
WD40 repeat [General function prediction only];
394-730 1.51e-44

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 165.08  E-value: 1.51e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74207704 394 VYRGHSDLVRCLSVSPGGQWLASGSDDGTLKLWEVATARCMKTV-HVGGVVRSIAWNPNPTIcLVAAAMDDAVLLLNPAl 472
Cdd:COG2319 115 TLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLtGHSGAVTSVAFSPDGKL-LASGSDDGTVRLWDLA- 192

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74207704 473 gdrllvgsTDQLLEAFTPpeepalqparwlevseeehqrglrlricHSKPVTQVTWHGRGDYLAVvlSSQEHTqVLLHQV 552
Cdd:COG2319 193 --------TGKLLRTLTG----------------------------HTGAVRSVAFSPDGKLLAS--GSADGT-VRLWDL 233

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74207704 553 SRRRSQSPFRRSHGQVQCVAFHPSRPFVLVASQ-RSIRIYHLLRQELTKKLMPNCKWVSSMAVHPAGDNIICGSYDSKLV 631
Cdd:COG2319 234 ATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSAdGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVR 313

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74207704 632 WFDLDlSTKPYKVLRHHKKALRAVAFHPRYPLFASGSDDGSVIVChgmvynDLLQNPLLvpvKVLKGHTLtrdlGVLDVA 711
Cdd:COG2319 314 LWDLA-TGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLW------DLATGELL---RTLTGHTG----AVTSVA 379

                       330
                ....*....|....*....
gi 74207704 712 FHPTQPWVFSSGADGTIRL 730
Cdd:COG2319 380 FSPDGRTLASGSADGTVRL 398
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 394-732 4.32e-44

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 160.19  E-value: 4.32e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74207704 394 VYRGHSDLVRCLSVSPGGQWLASGSDDGTLKLWEVATARCMKT--VHVGGVvRSIAWNPNpTICLVAAAMDDAVLLLNPa 471
Cdd:cd00200   4 TLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTlkGHTGPV-RDVAASAD-GTYLASGSSDKTIRLWDL- 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74207704 472 lgdrllvgSTDQLLEAFTppeepalqparwlevseeehqrglrlriCHSKPVTQVTWHGRGDYLAvvlSSQEHTQVLLHQ 551
Cdd:cd00200  81 --------ETGECVRTLT----------------------------GHTSYVSSVAFSPDGRILS---SSSRDKTIKVWD 121

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74207704 552 VSRRRSQSPFRrSH-GQVQCVAFHPSRPFVLVASQ-RSIRIYHLLRQELTKKLMPNCKWVSSMAVHPAGDNIICGSYDSK 629
Cdd:cd00200 122 VETGKCLTTLR-GHtDWVNSVAFSPDGTFVASSSQdGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGT 200

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74207704 630 L-VWfdlDLST-KPYKVLRHHKKALRAVAFHPRYPLFASGSDDGSVIVchgmvYNDLLQnpllVPVKVLKGHTLtrdlGV 707
Cdd:cd00200 201 IkLW---DLSTgKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRV-----WDLRTG----ECVQTLSGHTN----SV 264

                       330       340
                ....*....|....*....|....*
gi 74207704 708 LDVAFHPTQPWVFSSGADGTIRLFS 732
Cdd:cd00200 265 TSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
391-732 1.39e-37

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 145.05  E-value: 1.39e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74207704 391 QAIVYRGHSDLVRCLSVSPGGQWLASGSDDGTLKLWEVATARCMKT-VHVGGVVRSIAWNPNpticlvaaamddavllln 469
Cdd:COG2319  70 LLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTlTGHTGAVRSVAFSPD------------------ 131

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74207704 470 palGDRLLVGSTD---QLLEAFTPPEEPALQParwlevseeehqrglrlricHSKPVTQVTWHGRGDYLAVvlSSQEHTq 546
Cdd:COG2319 132 ---GKTLASGSADgtvRLWDLATGKLLRTLTG--------------------HSGAVTSVAFSPDGKLLAS--GSDDGT- 185

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74207704 547 VLLHQVSRRRSQSPFRRSHGQVQCVAFHPSRPFVLVASQ-RSIRIYHLLRQELTKKLMPNCKWVSSMAVHPAGDNIICGS 625
Cdd:COG2319 186 VRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSAdGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGS 265

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74207704 626 YDSKLVWFDLDlSTKPYKVLRHHKKALRAVAFHPRYPLFASGSDDGSVIVChgmvynDLLQNPLLvpvKVLKGHTLtrdl 705
Cdd:COG2319 266 ADGTVRLWDLA-TGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLW------DLATGKLL---RTLTGHTG---- 331

                       330       340
                ....*....|....*....|....*..
gi 74207704 706 GVLDVAFHPTQPWVFSSGADGTIRLFS 732
Cdd:COG2319 332 AVRSVAFSPDGKTLASGSDDGTVRLWD 358
WD40 COG2319
WD40 repeat [General function prediction only];
487-732 1.36e-20

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 94.98  E-value: 1.36e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74207704 487 AFTPPEEPALQPARWLEVSEEEHQRGLRLRICHSKPVTQVTWHGRGDYLAVVLSSQEHTQVLLHQVSRRRSQSPFRRSHG 566
Cdd:COG2319   1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74207704 567 QVQCVAFHPSRPFVLVASQRSIRIYHLLRQELTKKLMPNCKWVSSMAVHPAGDNIICGSYDSKLVWFDLDlSTKPYKVLR 646
Cdd:COG2319  81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLA-TGKLLRTLT 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74207704 647 HHKKALRAVAFHPRYPLFASGSDDGSVIVChgmvynDLLQNPLLvpvKVLKGHTltrdLGVLDVAFHPTQPWVFSSGADG 726
Cdd:COG2319 160 GHSGAVTSVAFSPDGKLLASGSDDGTVRLW------DLATGKLL---RTLTGHT----GAVRSVAFSPDGKLLASGSADG 226


                ....*.
gi 74207704 727 TIRLFS 732
Cdd:COG2319 227 TVRLWD 232
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 641-732 6.20e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 63.89  E-value: 6.20e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74207704 641 PYKVLRHHKKALRAVAFHPRYPLFASGSDDGSVIVChgmvynDLLQNPLLvpvKVLKGHTltrdLGVLDVAFHPTQPWVF 720
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVW------DLETGELL---RTLKGHT----GPVRDVAASADGTYLA 67

                        90
                ....*....|..
gi 74207704 721 SSGADGTIRLFS 732
Cdd:cd00200  68 SGSSDKTIRLWD 79
WD40 pfam00400
WD domain, G-beta repeat;
394-427 1.11e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 54.27  E-value: 1.11e-09
                          10        20        30
                  ....*....|....*....|....*....|....
gi 74207704   394 VYRGHSDLVRCLSVSPGGQWLASGSDDGTLKLWE 427
Cdd:pfam00400   6 TLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 394-427 1.73e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 53.47  E-value: 1.73e-09
                           10        20        30
                   ....*....|....*....|....*....|....
gi 74207704    394 VYRGHSDLVRCLSVSPGGQWLASGSDDGTLKLWE 427
Cdd:smart00320   7 TLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 COG2319
WD40 repeat [General function prediction only];
394-430 1.16e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 58.00  E-value: 1.16e-08
                        10        20        30
                ....*....|....*....|....*....|....*..
gi 74207704 394 VYRGHSDLVRCLSVSPGGQWLASGSDDGTLKLWEVAT 430
Cdd:COG2319 367 TLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 638-675 2.53e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.61  E-value: 2.53e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 74207704    638 STKPYKVLRHHKKALRAVAFHPRYPLFASGSDDGSVIV 675
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKL 38
WD40 pfam00400
WD domain, G-beta repeat;
692-732 4.90e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.87  E-value: 4.90e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 74207704   692 PVKVLKGHTLtrdlGVLDVAFHPTQPWVFSSGADGTIRLFS 732
Cdd:pfam00400   3 LLKTLEGHTG----SVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 692-732 7.30e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.46  E-value: 7.30e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 74207704    692 PVKVLKGHTLtrdlGVLDVAFHPTQPWVFSSGADGTIRLFS 732
Cdd:smart00320   4 LLKTLKGHTG----PVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
640-675 1.53e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.33  E-value: 1.53e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 74207704   640 KPYKVLRHHKKALRAVAFHPRYPLFASGSDDGSVIV 675
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKV 37
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 389-432 2.54e-04

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 43.91  E-value: 2.54e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 74207704   389 VCQAIvyRGHSDLVRCLSVSPGGQWLASGSDDGTLKLWEVATAR 432
Cdd:pfam20426 116 MVQSI--RQHKDVVSCVAVTSDGSILATGSYDTTVMVWEVLRGR 157
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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