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Conserved domains on  [gi|193786912|dbj|BAG52235|]
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unnamed protein product [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
64-338 1.47e-32

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 125.82  E-value: 1.47e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786912  64 NLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQLYPVGGPSQFSTIYSLN 143
Cdd:COG4886   23 TLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELD 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786912 144 MEHNRInkipfgiFSRAKVLSKLNMKDNQLTSLPLDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLP 223
Cdd:COG4886  103 LSGNEE-------LSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLP 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786912 224 HGLGNLRKLRELDLEENKLESLPNEIAYLKDLQKLVLTNNQLTTLPRGIGHLTNLTHLGLGENLLTHLPeEIGTLENLEE 303
Cdd:COG4886  176 EELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEE 254

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 193786912 304 LYLNDNpNLHSLPFELALcSKLSIMSIENCPLSHL 338
Cdd:COG4886  255 LDLSNN-QLTDLPPLANL-TNLKTLDLSNNQLTDL 287
PLN03150 super family cl31977
hypothetical protein; Provisional
 38-87 6.38e-04

hypothetical protein; Provisional


The actual alignment was detected with superfamily member PLN03150:

Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 41.73  E-value: 6.38e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 193786912  38 DIKNLSKLSMLSIRENKIK-QLPAEIGNLSSLSRLGLRYNRLS-AIPRSLAK 87
Cdd:PLN03150 437 DISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQ 488
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
64-338 1.47e-32

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 125.82  E-value: 1.47e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786912  64 NLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQLYPVGGPSQFSTIYSLN 143
Cdd:COG4886   23 TLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELD 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786912 144 MEHNRInkipfgiFSRAKVLSKLNMKDNQLTSLPLDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLP 223
Cdd:COG4886  103 LSGNEE-------LSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLP 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786912 224 HGLGNLRKLRELDLEENKLESLPNEIAYLKDLQKLVLTNNQLTTLPRGIGHLTNLTHLGLGENLLTHLPeEIGTLENLEE 303
Cdd:COG4886  176 EELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEE 254

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 193786912 304 LYLNDNpNLHSLPFELALcSKLSIMSIENCPLSHL 338
Cdd:COG4886  255 LDLSNN-QLTDLPPLANL-TNLKTLDLSNNQLTDL 287
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
23-336 3.53e-17

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 82.82  E-value: 3.53e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786912  23 TTLYLRFNRITTVEKDIKnlSKLSMLSIRENKIKQLPAEI-GNLSSLSrlgLRYNRLSAIPrslakcsaleelnlennni 101
Cdd:PRK15370 181 TELRLKILGLTTIPACIP--EQITTLILDNNELKSLPENLqGNIKTLY---ANSNQLTSIP------------------- 236

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786912 102 STLPESLlsslvklNSLTLARNCFQLYPVGGPSqfsTIYSLNMEHNRINKIPFGIfsrAKVLSKLNMKDNQLTSLPLDFG 181
Cdd:PRK15370 237 ATLPDTI-------QEMELSINRITELPERLPS---ALQSLDLFHNKISCLPENL---PEELRYLSVYDNSIRTLPAHLP 303

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786912 182 TwtSMVELNLATNQLTKIPEDVSglVSLEVLILSNNLLKKLPhglgnlrklreldleenklESLPNEiaylkdLQKLVLT 261
Cdd:PRK15370 304 S--GITHLNVQSNSLTALPETLP--PGLKTLEAGENALTSLP-------------------ASLPPE------LQVLDVS 354

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 193786912 262 NNQLTTLPRGIGhlTNLTHLGLGENLLTHLPEEI-GTLENLEELYLNDNPNLHSLPFELALCSKLSIMSIENCPLS 336
Cdd:PRK15370 355 KNQITVLPETLP--PTITTLDVSRNALTNLPENLpAALQIMQASRNNLVRLPESLPHFRGEGPQPTRIIVEYNPFS 428
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 142-310 6.65e-17

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 78.67  E-value: 6.65e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786912 142 LNMEHNRINKIpfGIFSRAKVLSKLNMKDNQLTSLPlDFGTWTSMVELNLATNQLTKIpEDVSGLVSLEVLILSNNLLKK 221
Cdd:cd21340    7 LYLNDKNITKI--DNLSLCKNLKVLYLYDNKITKIE-NLEFLTNLTHLYLQNNQIEKI-ENLENLVNLKKLYLGGNRISV 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786912 222 LpHGLGNLRKLRELDLE------ENKLESLPNEIAYLKD-LQKLVLTNNQLTTLpRGIGHLTNLTHLGLGENLLTHLPE- 293
Cdd:cd21340   83 V-EGLENLTNLEELHIEnqrlppGEKLTFDPRSLAALSNsLRVLNISGNNIDSL-EPLAPLRNLEQLDASNNQISDLEEl 160

                        170
                 ....*....|....*....
gi 193786912 294 --EIGTLENLEELYLNDNP 310
Cdd:cd21340  161 ldLLSSWPSLRELDLTGNP 179
LRR_8 pfam13855
Leucine rich repeat;
208-265 7.14e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.90  E-value: 7.14e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786912  208 SLEVLILSNNLLKKLPHG-LGNLRKLRELDLEENKLESL-PNEIAYLKDLQKLVLTNNQL 265
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGaFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
PLN03150 PLN03150
hypothetical protein; Provisional
 38-87 6.38e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 41.73  E-value: 6.38e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 193786912  38 DIKNLSKLSMLSIRENKIK-QLPAEIGNLSSLSRLGLRYNRLS-AIPRSLAK 87
Cdd:PLN03150 437 DISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQ 488
LRR_8 pfam13855
Leucine rich repeat;
21-73 9.82e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.12  E-value: 9.82e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 193786912   21 SLTTLYLRFNRITTVEKDI-KNLSKLSMLSIRENKIKQL-PAEIGNLSSLSRLGL 73
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDL 56
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
64-338 1.47e-32

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 125.82  E-value: 1.47e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786912  64 NLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQLYPVGGPSQFSTIYSLN 143
Cdd:COG4886   23 TLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELD 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786912 144 MEHNRInkipfgiFSRAKVLSKLNMKDNQLTSLPLDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLP 223
Cdd:COG4886  103 LSGNEE-------LSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLP 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786912 224 HGLGNLRKLRELDLEENKLESLPNEIAYLKDLQKLVLTNNQLTTLPRGIGHLTNLTHLGLGENLLTHLPeEIGTLENLEE 303
Cdd:COG4886  176 EELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEE 254

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 193786912 304 LYLNDNpNLHSLPFELALcSKLSIMSIENCPLSHL 338
Cdd:COG4886  255 LDLSNN-QLTDLPPLANL-TNLKTLDLSNNQLTDL 287
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
175-340 1.22e-30

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 120.81  E-value: 1.22e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786912 175 SLPLDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEENKLESLPNEIAYLKD 254
Cdd:COG4886  104 SGNEELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTN 183

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786912 255 LQKLVLTNNQLTTLPRGIGHLTNLTHLGLGENLLTHLPEEIGTLENLEELYLNDNpNLHSLPfELALCSKLSIMSIENCP 334
Cdd:COG4886  184 LKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNN-QLTDLP-ELGNLTNLEELDLSNNQ 261


                 ....*.
gi 193786912 335 LSHLPP 340
Cdd:COG4886  262 LTDLPP 267
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
9-310 3.39e-28

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 113.88  E-value: 3.39e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786912   9 LREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSMLSIRENKIKQLPAEIGNLSSLSRLGLRYNRLSAIPRSLAKC 88
Cdd:COG4886   16 LLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDL 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786912  89 SALEELNlennnistlpesllsslvklnsltlarncfqLYPVGGPSQFSTIYSLNMEHNRINKIPFGIfSRAKVLSKLNM 168
Cdd:COG4886   96 TNLTELD-------------------------------LSGNEELSNLTNLESLDLSGNQLTDLPEEL-ANLTNLKELDL 143

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786912 169 KDNQLTSLPLDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEENKLESLPNE 248
Cdd:COG4886  144 SNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEP 223

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 193786912 249 IAYLKDLQKLVLTNNQLTTLPrGIGHLTNLTHLGLGENLLTHLPEEiGTLENLEELYLNDNP 310
Cdd:COG4886  224 LANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLPPL-ANLTNLKTLDLSNNQ 283
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
169-342 2.05e-23

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 100.39  E-value: 2.05e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786912 169 KDNQLTSLPLDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLlkklphGLGNLRKLRELDLEENKLESLPNE 248
Cdd:COG4886   58 RDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE------ELSNLTNLESLDLSGNQLTDLPEE 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786912 249 IAYLKDLQKLVLTNNQLTTLPRGIGHLTNLTHLGLGENLLTHLPEEIGTLENLEELYLNDNpNLHSLPFELALCSKLSIM 328
Cdd:COG4886  132 LANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNN-QITDLPEPLGNLTNLEEL 210

                        170
                 ....*....|....
gi 193786912 329 SIENCPLSHLPPQI 342
Cdd:COG4886  211 DLSGNQLTDLPEPL 224
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
2-339 2.19e-23

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 100.39  E-value: 2.19e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786912   2 LDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSMLSIRENKikqlpaEIGNLSSLSRLGLRYNRLSAI 81
Cdd:COG4886   55 LLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE------ELSNLTNLESLDLSGNQLTDL 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786912  82 PRSLAKCSALEELNLENNNISTLPESLlsslvklnsltlarncfqlypvggpSQFSTIYSLNMEHNRINKIPFGIfSRAK 161
Cdd:COG4886  129 PEELANLTNLKELDLSNNQLTDLPEPL-------------------------GNLTNLKSLDLSNNQLTDLPEEL-GNLT 182

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786912 162 VLSKLNMKDNQLTSLPLDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPhGLGNLRKLRELDLEENK 241
Cdd:COG4886  183 NLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQ 261

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786912 242 LESLPnEIAYLKDLQKLVLTNNQLTTLprGIGHLTNLTHLGLGENLLTHLPEEIGTLENLEELYLNDNPNLHSLPFELAL 321
Cdd:COG4886  262 LTDLP-PLANLTNLKTLDLSNNQLTDL--KLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLT 338

                        330
                 ....*....|....*...
gi 193786912 322 CSKLSIMSIENCPLSHLP 339
Cdd:COG4886  339 TLALSLSLLALLTLLLLL 356
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
2-269 1.57e-22

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 97.70  E-value: 1.57e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786912   2 LDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSMLSIRENKIKQLPAEIGNLSSLSRLGLRYNRLSAI 81
Cdd:COG4886  118 LDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDL 197

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786912  82 PRSLAKCSALEELNLENNNISTLPESlLSSLVKLNSLTLARNcfQLYPVGGPSQFSTIYSLNMEHNRINKIPFgiFSRAK 161
Cdd:COG4886  198 PEPLGNLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNN--QLTDLPELGNLTNLEELDLSNNQLTDLPP--LANLT 272

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786912 162 VLSKLNMKDNQLTSLPLDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEENK 241
Cdd:COG4886  273 NLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTL 352

                        250       260
                 ....*....|....*....|....*...
gi 193786912 242 LESLPNEIAYLKDLQKLVLTNNQLTTLP 269
Cdd:COG4886  353 LLLLNLLSLLLTLLLTLGLLGLLEATLL 380
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
16-319 5.82e-22

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 96.16  E-value: 5.82e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786912  16 VYRLDSLTTLYLRFNRITTVEKDIKNLSKLSMLSIRENKIKQLPAEIGNLSSLSRLGLRYNRLSAIPRSLAKCSALEELN 95
Cdd:COG4886  109 LSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELD 188

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786912  96 LENNNISTLPESlLSSLVKLNSLTLArncfqlypvggpsqfstiyslnmehnrinkipfgifsrakvlsklnmkDNQLTS 175
Cdd:COG4886  189 LSNNQITDLPEP-LGNLTNLEELDLS------------------------------------------------GNQLTD 219

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786912 176 LPLDFGTWTSMVELNLATNQLTKIPEdVSGLVSLEVLILSNNLLKKLPHgLGNLRKLRELDLEENKLESLPNEIAYLKDL 255
Cdd:COG4886  220 LPEPLANLTNLETLDLSNNQLTDLPE-LGNLTNLEELDLSNNQLTDLPP-LANLTNLKTLDLSNNQLTDLKLKELELLLG 297

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 193786912 256 QKLVLTNNQLTTLPRGIGHLTNLTHLGLGENLLTHLPEEIGTLENLEELYLNDNPNLHSLPFEL 319
Cdd:COG4886  298 LNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSL 361
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
23-336 3.53e-17

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 82.82  E-value: 3.53e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786912  23 TTLYLRFNRITTVEKDIKnlSKLSMLSIRENKIKQLPAEI-GNLSSLSrlgLRYNRLSAIPrslakcsaleelnlennni 101
Cdd:PRK15370 181 TELRLKILGLTTIPACIP--EQITTLILDNNELKSLPENLqGNIKTLY---ANSNQLTSIP------------------- 236

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786912 102 STLPESLlsslvklNSLTLARNCFQLYPVGGPSqfsTIYSLNMEHNRINKIPFGIfsrAKVLSKLNMKDNQLTSLPLDFG 181
Cdd:PRK15370 237 ATLPDTI-------QEMELSINRITELPERLPS---ALQSLDLFHNKISCLPENL---PEELRYLSVYDNSIRTLPAHLP 303

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786912 182 TwtSMVELNLATNQLTKIPEDVSglVSLEVLILSNNLLKKLPhglgnlrklreldleenklESLPNEiaylkdLQKLVLT 261
Cdd:PRK15370 304 S--GITHLNVQSNSLTALPETLP--PGLKTLEAGENALTSLP-------------------ASLPPE------LQVLDVS 354

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 193786912 262 NNQLTTLPRGIGhlTNLTHLGLGENLLTHLPEEI-GTLENLEELYLNDNPNLHSLPFELALCSKLSIMSIENCPLS 336
Cdd:PRK15370 355 KNQITVLPETLP--PTITTLDVSRNALTNLPENLpAALQIMQASRNNLVRLPESLPHFRGEGPQPTRIIVEYNPFS 428
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 142-310 6.65e-17

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 78.67  E-value: 6.65e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786912 142 LNMEHNRINKIpfGIFSRAKVLSKLNMKDNQLTSLPlDFGTWTSMVELNLATNQLTKIpEDVSGLVSLEVLILSNNLLKK 221
Cdd:cd21340    7 LYLNDKNITKI--DNLSLCKNLKVLYLYDNKITKIE-NLEFLTNLTHLYLQNNQIEKI-ENLENLVNLKKLYLGGNRISV 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786912 222 LpHGLGNLRKLRELDLE------ENKLESLPNEIAYLKD-LQKLVLTNNQLTTLpRGIGHLTNLTHLGLGENLLTHLPE- 293
Cdd:cd21340   83 V-EGLENLTNLEELHIEnqrlppGEKLTFDPRSLAALSNsLRVLNISGNNIDSL-EPLAPLRNLEQLDASNNQISDLEEl 160

                        170
                 ....*....|....*....
gi 193786912 294 --EIGTLENLEELYLNDNP 310
Cdd:cd21340  161 ldLLSSWPSLRELDLTGNP 179
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 135-344 6.82e-17

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 82.20  E-value: 6.82e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786912 135 QFSTIYSLNMEHNRIN-KIPFGIFSRAKVLSKLNMKDNQLTSlPLDFGTWTSMVELNLATNQLT-KIPEDVSGLVSLEVL 212
Cdd:PLN00113  91 RLPYIQTINLSNNQLSgPIPDDIFTTSSSLRYLNLSNNNFTG-SIPRGSIPNLETLDLSNNMLSgEIPNDIGSFSSLKVL 169

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786912 213 ILSNN-LLKKLPHGLGNLRKLRELDLEENKLE-SLPNEIAYLKDLQKLVLTNNQLT-TLPRGIGHLTNLTHLGLGENLLT 289
Cdd:PLN00113 170 DLGGNvLVGKIPNSLTNLTSLEFLTLASNQLVgQIPRELGQMKSLKWIYLGYNNLSgEIPYEIGGLTSLNHLDLVYNNLT 249

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 193786912 290 -HLPEEIGTLENLEELYLNDNPNLHSLPFELALCSKLSIMSIENCPLSHLPPQIVA 344
Cdd:PLN00113 250 gPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSGEIPELVI 305
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 2-325 1.20e-15

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 78.35  E-value: 1.20e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786912   2 LDLRHNKLR-EIPSVVYRLDSLTTLYLRFNRIT-TVEKDIKNLSKLSMLSIRENKIK-QLPAEIGNLSSLSRLGLRYNRL 78
Cdd:PLN00113 169 LDLGGNVLVgKIPNSLTNLTSLEFLTLASNQLVgQIPRELGQMKSLKWIYLGYNNLSgEIPYEIGGLTSLNHLDLVYNNL 248

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786912  79 SA-IPRSLAKCSALEELNLENNNIS-TLPESLLsSLVKLNSLTLARNCFQLYPVGGPSQFSTIYSLNMEHNRIN-KIPFG 155
Cdd:PLN00113 249 TGpIPSSLGNLKNLQYLFLYQNKLSgPIPPSIF-SLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTgKIPVA 327

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786912 156 IFSRAKvLSKLNMKDNQLT-SLPLDFGTWTSMVELNLATNQLT-KIPEDVSGLVSLEVLIL-SNNLLKKLPHGLGNLRKL 232
Cdd:PLN00113 328 LTSLPR-LQVLQLWSNKFSgEIPKNLGKHNNLTVLDLSTNNLTgEIPEGLCSSGNLFKLILfSNSLEGEIPKSLGACRSL 406

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786912 233 RELDLEENKLE-SLPNEIAYLKDLQKLVLTNNQLT-------------------------TLPRGIGHlTNLTHLGLGEN 286
Cdd:PLN00113 407 RRVRLQDNSFSgELPSEFTKLPLVYFLDISNNNLQgrinsrkwdmpslqmlslarnkffgGLPDSFGS-KRLENLDLSRN 485

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|
gi 193786912 287 LLTH-LPEEIGTLENLEELYLNDNPNLHSLPFELALCSKL 325
Cdd:PLN00113 486 QFSGaVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKL 525
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
1-249 7.17e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 75.36  E-value: 7.17e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786912   1 MLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSMLSIRENKIKQLPAEIGNLSSLSRLGLRYNRLSA 80
Cdd:COG4886  163 SLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTD 242

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786912  81 IPrSLAKCSALEELNLENNNISTLPEslLSSLVKLNSLTLARNCF------QLYPVGGPSQFSTIYSLNMEHNRINKIPF 154
Cdd:COG4886  243 LP-ELGNLTNLEELDLSNNQLTDLPP--LANLTNLKTLDLSNNQLtdlklkELELLLGLNSLLLLLLLLNLLELLILLLL 319

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786912 155 GIFSRAKVLSKLNMKDNQLTSLPLDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRE 234
Cdd:COG4886  320 LTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAG 399

                        250
                 ....*....|....*
gi 193786912 235 LDLEENKLESLPNEI 249
Cdd:COG4886  400 VLLLTLALLDAVNTE 414
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
2-230 5.81e-14

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 73.19  E-value: 5.81e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786912   2 LDLRHNKLREIPSVVYrlDSLTTLYLRFNRITTVEKDIKNLSKLSMLSIreNKIKQLPAEIGnlSSLSRLGLRYNRLSAI 81
Cdd:PRK15370 204 LILDNNELKSLPENLQ--GNIKTLYANSNQLTSIPATLPDTIQEMELSI--NRITELPERLP--SALQSLDLFHNKISCL 277

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786912  82 PRSLAKcsALEELNLENNNISTLPESLLSSLVKLNsltLARNCFQLYPVGGPSQFSTiysLNMEHNRINKIPFGIFSRAK 161
Cdd:PRK15370 278 PENLPE--ELRYLSVYDNSIRTLPAHLPSGITHLN---VQSNSLTALPETLPPGLKT---LEAGENALTSLPASLPPELQ 349

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 193786912 162 VLSklnMKDNQLTSLPLDFGtwTSMVELNLATNQLTKIPEDVSGlvSLEVLILSNNLLKKLPHGLGNLR 230
Cdd:PRK15370 350 VLD---VSKNQITVLPETLP--PTITTLDVSRNALTNLPENLPA--ALQIMQASRNNLVRLPESLPHFR 411
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 29-330 4.23e-13

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 70.65  E-value: 4.23e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786912  29 FNRITTVEKDIKNLS-KLSMLsirenkIKQLP-AEIGNLSSlsrlglryNRLSA-IPRSL-AKCSALEELNLENNNIS-T 103
Cdd:PLN00113  68 SSRVVSIDLSGKNISgKISSA------IFRLPyIQTINLSN--------NQLSGpIPDDIfTTSSSLRYLNLSNNNFTgS 133

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786912 104 LPESLLSSLvklnsltlarncfqlypvggpsqfstiYSLNMEHNRIN-KIP--FGIFSRAKVlskLNMKDNQLTS-LPLD 179
Cdd:PLN00113 134 IPRGSIPNL---------------------------ETLDLSNNMLSgEIPndIGSFSSLKV---LDLGGNVLVGkIPNS 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786912 180 FGTWTSMVELNLATNQLT-KIPEDVSGLVSLEVLILS-NNLLKKLPHGLGNLRKLRELDLEENKLE-SLPNEIAYLKDLQ 256
Cdd:PLN00113 184 LTNLTSLEFLTLASNQLVgQIPRELGQMKSLKWIYLGyNNLSGEIPYEIGGLTSLNHLDLVYNNLTgPIPSSLGNLKNLQ 263

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 193786912 257 KLVLTNNQLT-TLPRGIGHLTNLTHLGLGENLLT-HLPEEIGTLENLEELYLNDNPNLHSLPFELALCSKLSIMSI 330
Cdd:PLN00113 264 YLFLYQNKLSgPIPPSIFSLQKLISLDLSDNSLSgEIPELVIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQL 339
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 2-265 1.52e-11

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 65.64  E-value: 1.52e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786912   2 LDLRHNKLR-EIPSVVYRLDSLTTLYLRFNRIT-TVEKDIKNLSKLSMLSIRENKIK-QLPAEIGNLSSLSRLGLRYNRL 78
Cdd:PLN00113 289 LDLSDNSLSgEIPELVIQLQNLEILHLFSNNFTgKIPVALTSLPRLQVLQLWSNKFSgEIPKNLGKHNNLTVLDLSTNNL 368

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786912  79 SA-------------------------IPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQLYPVGGP 133
Cdd:PLN00113 369 TGeipeglcssgnlfklilfsnslegeIPKSLGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQGRINSRK 448

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786912 134 SQFSTIYSLNMEHNRInkipFG---IFSRAKVLSKLNMKDNQLT-SLPLDFGTWTSMVELNLATNQLT-KIPEDVSGLVS 208
Cdd:PLN00113 449 WDMPSLQMLSLARNKF----FGglpDSFGSKRLENLDLSRNQFSgAVPRKLGSLSELMQLKLSENKLSgEIPDELSSCKK 524

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 193786912 209 LEVLILS-NNLLKKLPHGLGNLRKLRELDLEENKLE-SLPNEIAYLKDLQKLVLTNNQL 265
Cdd:PLN00113 525 LVSLDLShNQLSGQIPASFSEMPVLSQLDLSQNQLSgEIPKNLGNVESLVQVNISHNHL 583
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
43-310 1.20e-10

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 62.87  E-value: 1.20e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786912  43 SKLSMLSIRENKIKQLPAEIGNLSSLSRLGLRYNRLSAIPRSLAKCSaleELNLENNNISTLPESLLSSLVKLNSLTLar 122
Cdd:PRK15387 222 AHITTLVIPDNNLTSLPALPPELRTLEVSGNQLTSLPVLPPGLLELS---IFSNPLTHLPALPSGLCKLWIFGNQLTS-- 296

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786912 123 ncfqlYPVGGPSqfstIYSLNMEHNRINKIPfgifSRAKVLSKLNMKDNQLTSLPLdfgTWTSMVELNLATNQLTKIPED 202
Cdd:PRK15387 297 -----LPVLPPG----LQELSVSDNQLASLP----ALPSELCKLWAYNNQLTSLPT---LPSGLQELSVSDNQLASLPTL 360

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786912 203 VSGLVSLEVLILSNNLLKKLPHGLgnlrklRELDLEENKLESLPneiAYLKDLQKLVLTNNQLTTLPRgigHLTNLTHLG 282
Cdd:PRK15387 361 PSELYKLWAYNNRLTSLPALPSGL------KELIVSGNRLTSLP---VLPSELKELMVSGNRLTSLPM---LPSGLLSLS 428

                        250       260
                 ....*....|....*....|....*...
gi 193786912 283 LGENLLTHLPEEIGTLENLEELYLNDNP 310
Cdd:PRK15387 429 VYRNQLTRLPESLIHLSSETTVNLEGNP 456
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
161-342 1.61e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 61.87  E-value: 1.61e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786912 161 KVLSKLNMKDNQLTSLPLDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEEN 240
Cdd:COG4886    4 LLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLS 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786912 241 KLESLPNEIAYLKDLQKLVLTNNQlttlprGIGHLTNLTHLGLGENLLTHLPEEIGTLENLEELYLNDNpNLHSLPFELA 320
Cdd:COG4886   84 LLLLGLTDLGDLTNLTELDLSGNE------ELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNN-QLTDLPEPLG 156

                        170       180
                 ....*....|....*....|..
gi 193786912 321 LCSKLSIMSIENCPLSHLPPQI 342
Cdd:COG4886  157 NLTNLKSLDLSNNQLTDLPEEL 178
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
163-339 7.77e-10

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 60.56  E-value: 7.77e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786912 163 LSKLNMKDNQLTSLPLdfgTWTSMVELNLATNQLTKIPEDVSGLVSLevLILSNNL--LKKLPHGlgnlrkLRELDLEEN 240
Cdd:PRK15387 244 LRTLEVSGNQLTSLPV---LPPGLLELSIFSNPLTHLPALPSGLCKL--WIFGNQLtsLPVLPPG------LQELSVSDN 312

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786912 241 KLESLPneiAYLKDLQKLVLTNNQLTTLPRgigHLTNLTHLGLGENLLTHLPeeigTL-ENLEELYLNDNpNLHSLPfel 319
Cdd:PRK15387 313 QLASLP---ALPSELCKLWAYNNQLTSLPT---LPSGLQELSVSDNQLASLP----TLpSELYKLWAYNN-RLTSLP--- 378

                        170       180
                 ....*....|....*....|
gi 193786912 320 ALCSKLSIMSIENCPLSHLP 339
Cdd:PRK15387 379 ALPSGLKELIVSGNRLTSLP 398
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 165-310 3.19e-07

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 51.59  E-value: 3.19e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786912 165 KLNMKDNQLTSLPLDFGTWTSMVELNLATNQLTK----IPEDVSGLVSLEVLILSNNLL-----KKLPHGLGNLR-KLRE 234
Cdd:cd00116   62 ETGRIPRGLQSLLQGLTKGCGLQELDLSDNALGPdgcgVLESLLRSSSLQELKLNNNGLgdrglRLLAKGLKDLPpALEK 141

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786912 235 LDLEENKL-----ESLPNEIAYLKDLQKLVLTNNQL-----TTLPRGIGHLTNLTHLGLGENLLTH-----LPEEIGTLE 299
Cdd:cd00116  142 LVLGRNRLegascEALAKALRANRDLKELNLANNGIgdagiRALAEGLKANCNLEVLDLNNNGLTDegasaLAETLASLK 221

                        170
                 ....*....|.
gi 193786912 300 NLEELYLNDNP 310
Cdd:cd00116  222 SLEVLNLGDNN 232
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 159-342 1.59e-06

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 50.26  E-value: 1.59e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786912  159 RAKVLSKLNMKDNQLTSLPLDFGTWTSMVELNL-ATNQLTKIPeDVSGLVSLEVLILSN-NLLKKLPHGLGNLRKLRELD 236
Cdd:PLN03210  609 RPENLVKLQMQGSKLEKLWDGVHSLTGLRNIDLrGSKNLKEIP-DLSMATNLETLKLSDcSSLVELPSSIQYLNKLEDLD 687

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786912  237 LEE-NKLESLPNEI-------------AYLK-------DLQKLVLTNNQLTTLPRGIgHLTNLTHLGLGENLLTHLPEEI 295
Cdd:PLN03210  688 MSRcENLEILPTGInlkslyrlnlsgcSRLKsfpdistNISWLDLDETAIEEFPSNL-RLENLDELILCEMKSEKLWERV 766

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 193786912  296 GTL--------ENLEELYLNDNPNLHSLPFELALCSKLSIMSIENCP-LSHLPPQI 342
Cdd:PLN03210  767 QPLtplmtmlsPSLTRLFLSDIPSLVELPSSIQNLHKLEHLEIENCInLETLPTGI 822
LRR_8 pfam13855
Leucine rich repeat;
208-265 7.14e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.90  E-value: 7.14e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786912  208 SLEVLILSNNLLKKLPHG-LGNLRKLRELDLEENKLESL-PNEIAYLKDLQKLVLTNNQL 265
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGaFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
PLN03150 PLN03150
hypothetical protein; Provisional
 199-273 1.01e-05

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 47.50  E-value: 1.01e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 193786912 199 IPEDVSGLVSLEVLILSNNLLK-KLPHGLGNLRKLRELDLEENKLE-SLPNEIAYLKDLQKLVLTNNQLT-TLPRGIG 273
Cdd:PLN03150 434 IPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSLSgRVPAALG 511
PLN03150 PLN03150
hypothetical protein; Provisional
 235-309 1.18e-05

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 47.12  E-value: 1.18e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 193786912 235 LDLEENKLES-LPNEIAYLKDLQKLVLTNNQLT-TLPRGIGHLTNLTHLGLGENLLT-HLPEEIGTLENLEELYLNDN 309
Cdd:PLN03150 423 LGLDNQGLRGfIPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGN 500
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 21-289 2.38e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 45.81  E-value: 2.38e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786912  21 SLTTLYLRFNRITTVEKDIKNLS--KLSMLSIRENKIKQLPAEIGNLSSLSRLGLRYNRLSAIPRSLAKCSaleelnlen 98
Cdd:cd00116    4 SLKGELLKTERATELLPKLLCLQvlRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETGRIPRGLQSLL--------- 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786912  99 nnistlpeSLLSSLVKLNSLTLARNCFQLYPVGGPSQFSTIYSL---NMEHNRINKIPF-----GIFSRAKVLSKLNMKD 170
Cdd:cd00116   75 --------QGLTKGCGLQELDLSDNALGPDGCGVLESLLRSSSLqelKLNNNGLGDRGLrllakGLKDLPPALEKLVLGR 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786912 171 NQLTS-----LPLDFGTWTSMVELNLATNQL-----TKIPEDVSGLVSLEVLILSNNLL-----KKLPHGLGNLRKLREL 235
Cdd:cd00116  147 NRLEGasceaLAKALRANRDLKELNLANNGIgdagiRALAEGLKANCNLEVLDLNNNGLtdegaSALAETLASLKSLEVL 226

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 193786912 236 DLEENKLESLPneIAYLKD--------LQKLVLTNNQLT-----TLPRGIGHLTNLTHLGLGENLLT 289
Cdd:cd00116  227 NLGDNNLTDAG--AAALASallspnisLLTLSLSCNDITddgakDLAEVLAEKESLLELDLRGNKFG 291
LRR_8 pfam13855
Leucine rich repeat;
255-310 5.04e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.59  E-value: 5.04e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 193786912  255 LQKLVLTNNQLTTLPRGI-GHLTNLTHLGLGENLLTHL-PEEIGTLENLEELYLNDNP 310
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNR 60
LRR_8 pfam13855
Leucine rich repeat;
184-242 5.78e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.59  E-value: 5.78e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 193786912  184 TSMVELNLATNQLTKIPEDV-SGLVSLEVLILSNNLLKKL-PHGLGNLRKLRELDLEENKL 242
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
230-288 9.27e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.82  E-value: 9.27e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 193786912  230 RKLRELDLEENKLESLPNEIAY-LKDLQKLVLTNNQLTTL-PRGIGHLTNLTHLGLGENLL 288
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKgLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 2-240 1.11e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 42.85  E-value: 1.11e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786912   2 LDLRHNKLREIPsVVYRLDSLTTLYLRFNRITTVEKdIKNLSKLSMLSIRENKIKQLPaEIGNLSSLSRLGLRYNRLSAI 81
Cdd:cd21340    7 LYLNDKNITKID-NLSLCKNLKVLYLYDNKITKIEN-LEFLTNLTHLYLQNNQIEKIE-NLENLVNLKKLYLGGNRISVV 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786912  82 prslakcsaleelnlennnistlpeSLLSSLVKLNSLTLARncfQLYPVGGPSQFStiyslnmehnrinkiPFGIFSRAK 161
Cdd:cd21340   84 -------------------------EGLENLTNLEELHIEN---QRLPPGEKLTFD---------------PRSLAALSN 120

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786912 162 VLSKLNMKDNQLTSLpldfgtwtsmvelnlatnqltkipEDVSGLVSLEVLILSNNLL---KKLPHGLGNLRKLRELDLE 238
Cdd:cd21340  121 SLRVLNISGNNIDSL------------------------EPLAPLRNLEQLDASNNQIsdlEELLDLLSSWPSLRELDLT 176


                 ..
gi 193786912 239 EN 240
Cdd:cd21340  177 GN 178
PLN03150 PLN03150
hypothetical protein; Provisional
 158-227 1.44e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 43.65  E-value: 1.44e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 193786912 158 SRAKVLSKLNMKDNQLT-SLPLDFGTWTSMVELNLATNQLT-KIPEDVSGLVSLEVLILSNNLLK-KLPHGLG 227
Cdd:PLN03150 439 SKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSLSgRVPAALG 511
PLN03150 PLN03150
hypothetical protein; Provisional
 38-87 6.38e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 41.73  E-value: 6.38e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 193786912  38 DIKNLSKLSMLSIRENKIK-QLPAEIGNLSSLSRLGLRYNRLS-AIPRSLAK 87
Cdd:PLN03150 437 DISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQ 488
LRR_8 pfam13855
Leucine rich repeat;
21-73 9.82e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.12  E-value: 9.82e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 193786912   21 SLTTLYLRFNRITTVEKDI-KNLSKLSMLSIRENKIKQL-PAEIGNLSSLSRLGL 73
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDL 56
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 40-333 5.34e-03

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 39.09  E-value: 5.34e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786912   40 KNLSKLSMlsiRENKIKQLPAEIGNLSSLSRLGLRYNR-LSAIPR----------SLAKCSAleelnlennnISTLPESl 108
Cdd:PLN03210  611 ENLVKLQM---QGSKLEKLWDGVHSLTGLRNIDLRGSKnLKEIPDlsmatnletlKLSDCSS----------LVELPSS- 676

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786912  109 LSSLVKLNSLTLARnCFQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRakvLSKLNMKDNQLTSLPLDFgTWTSMVE 188
Cdd:PLN03210  677 IQYLNKLEDLDMSR-CENLEILPTGINLKSLYRLNLSGCSRLKSFPDISTN---ISWLDLDETAIEEFPSNL-RLENLDE 751

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786912  189 LNLATNQLTKIPEDVSGLV--------SLEVLILSNN-LLKKLPHGLGNLRKLRELDLEENK-LESLPNEIAyLKDLQKL 258
Cdd:PLN03210  752 LILCEMKSEKLWERVQPLTplmtmlspSLTRLFLSDIpSLVELPSSIQNLHKLEHLEIENCInLETLPTGIN-LESLESL 830

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 193786912  259 VLTN-NQLTTLPrGIGhlTNLTHLGLGENLLTHLPEEIGTLENLEELYLNDNPNLHSLPFELALCSKLSIMSIENC 333
Cdd:PLN03210  831 DLSGcSRLRTFP-DIS--TNISDLNLSRTGIEEVPWWIEKFSNLSFLDMNGCNNLQRVSLNISKLKHLETVDFSDC 903
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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