Calcium-binding EGF domain;

                          10        20        30
                  ....*....|....*....|....*....|....*
gi 193784844   30 DVDECVGLQPVCPQGTTCINTGGSFQCVspeCPEG 64
Cdd:pfam07645   1 DVDECATGTHNCPANTVCVNTIGSFECR---CPDG 32

Calcium-binding EGF domain;

                          10        20        30
                  ....*....|....*....|....*....|....*
gi 193784844   30 DVDECVGLQPVCPQGTTCINTGGSFQCVspeCPEG 64
Cdd:pfam07645   1 DVDECATGTHNCPANTVCVNTIGSFECR---CPDG 32

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

                          10        20
                  ....*....|....*....|....*...
gi 193784844    1 MHACVNTPGSYRCTCPGGYRTLADGKSC 28
Cdd:pfam14670   9 SHLCLNTPGGYTCSCPEGYELQDDGRTC 36

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                         10        20        30
                 ....*....|....*....|....*....|....*
gi 193784844  30 DVDECVGLQPvCPQGTTCINTGGSFQCvspECPEG 64
Cdd:cd00054    1 DIDECASGNP-CQNGGTCVNTVGSYRC---SCPPG 31

Calcium-binding EGF domain;

                          10        20        30
                  ....*....|....*....|....*....|....*
gi 193784844   30 DVDECVGLQPVCPQGTTCINTGGSFQCVspeCPEG 64
Cdd:pfam07645   1 DVDECATGTHNCPANTVCVNTIGSFECR---CPDG 32

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

                          10        20
                  ....*....|....*....|....*...
gi 193784844    1 MHACVNTPGSYRCTCPGGYRTLADGKSC 28
Cdd:pfam14670   9 SHLCLNTPGGYTCSCPEGYELQDDGRTC 36

Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved cysteine residues disulfide-bonded into the characteriztic pattern 'ababcc'. They are found in blood coagulation proteins such as fibrillin, Clr and Cls, thrombomodulin, and the LDL receptor. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal cysteine residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In cEGFs the C-terminal thiol resides on the C-terminal beta-sheet, resulting in long loop-lengths between the cysteine residues of disulfide 'c', typically C[10+]XC. These longer loop-lengths may have arisen by selective cysteine loss from a four-disulfide EGF template such as laminin or integrin. Tandem cEGF domains have five linking residues between terminal cysteines of adjacent domains. cEGF domains may or may not bind calcium in the linker region. cEGF domains with the consensus motif CXN4X[F,Y]XCXC are hydroxylated exclusively on the asparagine residue.

                          10        20
                  ....*....|....*....|..
gi 193784844   12 RCTCPGGYRTLADGKSCEDVDE 33
Cdd:pfam12662   1 TCSCPPGYQLDPDGRTCVDIDE 22

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                         10        20
                 ....*....|....*....|....*.
gi 193784844   4 CVNTPGSYRCTCPGGYRtladGKSCE 29
Cdd:cd00054   17 CVNTVGSYRCSCPPGYT----GRNCE 38