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Conserved domains on  [gi|194376610|dbj|BAG57451|]
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unnamed protein product [Homo sapiens]

Protein Classification

choline transporter-like family protein( domain architecture ID 10517537)

choline transporter-like (CTL) family protein is involved in Na(+)-independent, high affinity choline transport to supply choline for the synthesis of cell membrane phospholipids to certain cell types

CATH:  1.10.287.110
Gene Ontology:  GO:0055085|GO:0022857
PubMed:  24745985
SCOP:  4000605
TCDB:  2.A.92

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Choline_transpo pfam04515
Plasma-membrane choline transporter; This family represents a high-affinity plasma-membrane ...
 1-112 2.63e-41

Plasma-membrane choline transporter; This family represents a high-affinity plasma-membrane choline transporter in C.elegans which is thought to be rate-limiting for ACh synthesis in cholinergic nerve terminals.


:

Pssm-ID: 461337  Cd Length: 325  Bit Score: 140.02  E-value: 2.63e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194376610    1 MIAIYGTNFCTSARNAFFLLMRNIIRVAVLDKVTDFLFLLGKLLIVGSVGILAFFFFTHRirivqDTAPPLNYYWVPILT 80
Cdd:pfam04515 219 MIAIYGKSFCTSAKDAFELLKRNGLRVAVNDCLGDFVLFLGKLFVALLTGLIAYLYLRFT-----TNPASLNSPVVPLLV 293

                          90       100       110
                  ....*....|....*....|....*....|..
gi 194376610   81 VIVGSYLIAHGFFSVYGMCVDTLFLCFCEDLE 112
Cdd:pfam04515 294 AFLIGYLIASIFMSVYESGVDTIFLCFAEDPE 325
 
Name Accession Description Interval E-value
Choline_transpo pfam04515
Plasma-membrane choline transporter; This family represents a high-affinity plasma-membrane ...
 1-112 2.63e-41

Plasma-membrane choline transporter; This family represents a high-affinity plasma-membrane choline transporter in C.elegans which is thought to be rate-limiting for ACh synthesis in cholinergic nerve terminals.


Pssm-ID: 461337  Cd Length: 325  Bit Score: 140.02  E-value: 2.63e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194376610    1 MIAIYGTNFCTSARNAFFLLMRNIIRVAVLDKVTDFLFLLGKLLIVGSVGILAFFFFTHRirivqDTAPPLNYYWVPILT 80
Cdd:pfam04515 219 MIAIYGKSFCTSAKDAFELLKRNGLRVAVNDCLGDFVLFLGKLFVALLTGLIAYLYLRFT-----TNPASLNSPVVPLLV 293

                          90       100       110
                  ....*....|....*....|....*....|..
gi 194376610   81 VIVGSYLIAHGFFSVYGMCVDTLFLCFCEDLE 112
Cdd:pfam04515 294 AFLIGYLIASIFMSVYESGVDTIFLCFAEDPE 325
 
Name Accession Description Interval E-value
Choline_transpo pfam04515
Plasma-membrane choline transporter; This family represents a high-affinity plasma-membrane ...
 1-112 2.63e-41

Plasma-membrane choline transporter; This family represents a high-affinity plasma-membrane choline transporter in C.elegans which is thought to be rate-limiting for ACh synthesis in cholinergic nerve terminals.


Pssm-ID: 461337  Cd Length: 325  Bit Score: 140.02  E-value: 2.63e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194376610    1 MIAIYGTNFCTSARNAFFLLMRNIIRVAVLDKVTDFLFLLGKLLIVGSVGILAFFFFTHRirivqDTAPPLNYYWVPILT 80
Cdd:pfam04515 219 MIAIYGKSFCTSAKDAFELLKRNGLRVAVNDCLGDFVLFLGKLFVALLTGLIAYLYLRFT-----TNPASLNSPVVPLLV 293

                          90       100       110
                  ....*....|....*....|....*....|..
gi 194376610   81 VIVGSYLIAHGFFSVYGMCVDTLFLCFCEDLE 112
Cdd:pfam04515 294 AFLIGYLIASIFMSVYESGVDTIFLCFAEDPE 325
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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