calponin homology (CH) domain superfamily; CH domains are actin filament (F-actin) binding motifs, which may be present as a single copy or in tandem repeats (which increase binding affinity). They either function as autonomous actin binding motifs or serve a regulatory function. CH domains are found in cytoskeletal and signal transduction proteins, including actin-binding proteins like spectrin, alpha-actinin, dystrophin, utrophin, and fimbrin, as well as proteins essential for regulation of cell shape (cortexillins), and signaling proteins (Vav).

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194376642   1 MSIGPNFQLGLKDGIILCELINKLQPGSVKKVNESSLNWPQLENIGNFIKAIQAYGMKPHDIFEANDLFENGNMTQVQTT 80
Cdd:cd21284   20 MSIGENFQKGLKDGVILCELINKLQPGSIRKINESKLNWHQLENIGNFIKAIQAYGMKPHDIFEANDLFENGNMTQVQTT 99

                         90
                 ....*....|..
gi 194376642  81 LVALAGLAKTKG 92
Cdd:cd21284  100 LLALAGLAKTKG 111

Calponin family repeat;

                          10        20
                  ....*....|....*....|....*
gi 194376642  202 ISLQMGTNKVASQKGMSVYGLGRQV 226
Cdd:pfam00402   1 IGLQMGTNKGASQSGMTAFGAVRHI 25

calponin homology (CH) domain found in calponin-3; Calponin-3 (CNN3), also called acidic isoform calponin, is an F-actin-binding protein that is expressed in the brain and has been shown to control dendritic spine morphology, density, and plasticity by regulating actin cytoskeletal reorganization and dynamics. It contains a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194376642   1 MSIGPNFQLGLKDGIILCELINKLQPGSVKKVNESSLNWPQLENIGNFIKAIQAYGMKPHDIFEANDLFENGNMTQVQTT 80
Cdd:cd21284   20 MSIGENFQKGLKDGVILCELINKLQPGSIRKINESKLNWHQLENIGNFIKAIQAYGMKPHDIFEANDLFENGNMTQVQTT 99

                         90
                 ....*....|..
gi 194376642  81 LVALAGLAKTKG 92
Cdd:cd21284  100 LLALAGLAKTKG 111

Calponin homology (CH) domain; The CH domain is found in both cytoskeletal proteins and signal transduction proteins. The CH domain is involved in actin binding in some members of the family. However in calponins there is evidence that the CH domain is not involved in its actin binding activity. Most member proteins have from two to four copies of the CH domain, however some proteins such as calponin have only a single copy.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194376642    6 NFQLGLKDGIILCELINKLQPGSVKKVNESSLNWPQLENIGNFIK-AIQAYGMKPHDIfEANDLFENGNMtQVQTTLVAL 84
Cdd:pfam00307  26 NFTTDLRDGLALCALLNKLAPGLVDKKKLNKSEFDKLENINLALDvAEKKLGVPKVLI-EPEDLVEGDNK-SVLTYLASL 103

                  ....*.
gi 194376642   85 AGLAKT 90
Cdd:pfam00307 104 FRRFQA 109

Calponin family repeat;

                          10        20
                  ....*....|....*....|....*
gi 194376642  123 IGLQMGTNKCASQAGMTAYGTRRHL 147
Cdd:pfam00402   1 IGLQMGTNKGASQSGMTAFGAVRHI 25

Calponin family repeat;

                          10        20
                  ....*....|....*....|....*
gi 194376642  163 ISLQMGTNKGASQAGMLAPGTRRDI 187
Cdd:pfam00402   1 IGLQMGTNKGASQSGMTAFGAVRHI 25

calponin homology (CH) domain found in calponin-3; Calponin-3 (CNN3), also called acidic isoform calponin, is an F-actin-binding protein that is expressed in the brain and has been shown to control dendritic spine morphology, density, and plasticity by regulating actin cytoskeletal reorganization and dynamics. It contains a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194376642   1 MSIGPNFQLGLKDGIILCELINKLQPGSVKKVNESSLNWPQLENIGNFIKAIQAYGMKPHDIFEANDLFENGNMTQVQTT 80
Cdd:cd21284   20 MSIGENFQKGLKDGVILCELINKLQPGSIRKINESKLNWHQLENIGNFIKAIQAYGMKPHDIFEANDLFENGNMTQVQTT 99

                         90
                 ....*....|..
gi 194376642  81 LVALAGLAKTKG 92
Cdd:cd21284  100 LLALAGLAKTKG 111

calponin homology (CH) domain found in calponin-2; Calponin-2 (CNN2), also called neutral calponin, or smooth muscle calponin H2, is an actin cytoskeleton-associated regulatory protein that inhibits the activity of myosin-ATPase and cytoskeleton dynamics. It contains a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194376642   1 MSIGPNFQLGLKDGIILCELINKLQPGSVKKVNESSLNWPQLENIGNFIKAIQAYGMKPHDIFEANDLFENGNMTQVQTT 80
Cdd:cd21283   18 RSIGPDFQKGLKDGVILCELMNKLQPGSVPKINRSMQNWHQLENLSNFIKAMVSYGMKPVDLFEANDLFESGNMTQVQVS 97

                         90
                 ....*....|..
gi 194376642  81 LVALAGLAKTKG 92
Cdd:cd21283   98 LLALAGMAKTKG 109

calponin homology (CH) domain found in Drosophila melanogaster muscle-specific protein 20 (dMP20) and similar domains; This subfamily contains Drosophila melanogaster muscle-specific protein 20 (dMP20), Echinococcus granulosus myophilin, Dictyostelium discoideum Rac guanine nucleotide exchange factor B (also called Trix), and similar proteins. dMP20 is present only in the synchronous muscles of D. melanogaster. It may be involved in the system linking the nerve impulse with the contraction or the relaxation process. Trix is involved in the regulation of the late steps of the endocytic pathway. dMP20 contains a single copy of the CH domain, while Trix (triple CH-domain array exchange factor) contains three, two type 3 CH domains which are included in this model, and one type 1 CH domain that is not included in this subfamily, but is part of the superfamily. CH domains are actin filament (F-actin) binding motifs.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194376642   6 NFQLGLKDGIILCELINKLQPGSVKKVNESSLNWPQLENIGNFIKAIQAYGMKPHDIFEANDLFENGNMTQVQTTLVALA 85
Cdd:cd21207   27 DYEDVLKDGVILCKLINILKPGSVKKINTSKMAFKLMENIENFLTACKGYGVPKTDLFQTVDLYEKKNIPQVTNCLFALG 106

                 .
gi 194376642  86 G 86
Cdd:cd21207  107 R 107

calponin homology (CH) domain superfamily; CH domains are actin filament (F-actin) binding motifs, which may be present as a single copy or in tandem repeats (which increase binding affinity). They either function as autonomous actin binding motifs or serve a regulatory function. CH domains are found in cytoskeletal and signal transduction proteins, including actin-binding proteins like spectrin, alpha-actinin, dystrophin, utrophin, and fimbrin, as well as proteins essential for regulation of cell shape (cortexillins), and signaling proteins (Vav).

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194376642   6 NFQLGLKDGIILCELINKLQPGSVKKVNESSLN-WPQLENIGNFIKAIQAYGMKPHDIFEANDLFENGNMTQVQTTLVAL 84
Cdd:cd00014   22 DLFESLRDGVLLCKLINKLSPGSIPKINKKPKSpFKKRENINLFLNACKKLGLPELDLFEPEDLYEKGNLKKVLGTLWAL 101

                 .
gi 194376642  85 A 85
Cdd:cd00014  102 A 102

calponin homology (CH) domain found in transgelin-2; Transgelin-2, also called epididymis tissue protein Li 7e, or SM22-alpha homolog, acts as an actin-binding protein that induces actin gelation and regulates the actin cytoskeleton. It may participate in the development and progression of multiple cancers. It contains a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194376642   6 NFQLGLKDGIILCELINKLQPGS---VKKVNESSLNWPQLENIGNFIKAIQAYGMKPHDIFEANDLFENGNMTQVQTTLV 82
Cdd:cd21280   34 NFQNWLKDGTVLCHLINSLYPKGqapVKKIQASTMAFKQMEQISQFLQAAERYGINTTDIFQTVDLWEGKNMASVQRTLM 113

                 ....*....
gi 194376642  83 ALAGLAKTK 91
Cdd:cd21280  114 NLGGLAVTR 122

Calponin [Cytoskeleton];

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194376642  11 LKDGIILCELINKLQPGSVKkVNESSLNWPQLENIGNFIKAIQAYGMKPHDIFEANDLFENGNMTQVQTTLVALAGLAKT 90
Cdd:COG5199   40 LKDGVRLCRILNEASPLDIK-YKESKMPFVQMENISSFINGLKKLRVPEYELFQTNDLFEAKDLRQVVICLYSLSRYAQK 118

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 194376642  91 KGFHTTIDIGVKYAEKQTRRFDEGK-LKAGQSVIGLQMGTNKCASQAG-MTAYGTRRHL 147
Cdd:COG5199  119 ERMFSGPFLGPHLATKKPRVFSSQEvLDRSKGAIHLQYGYSDLSEQSTeKGASNVRRDL 177

Calponin homology domain; Actin binding domains present in duplicate at the N-termini of spectrin-like proteins (including dystrophin, alpha-actinin). These domains cross-link actin filaments into bundles and networks. A calponin homology domain is predicted in yeasst Cdc24p.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194376642     6 NFQLGLKDGIILCELINKLQPGSV--KKVNESSLNWPQLENIGNFIKAIQAYGMKPhDIFEANDLFENGNMT-QVQTTLV 82
Cdd:smart00033  21 NFSSDLKDGVALCALLNSLSPGLVdkKKVAASLSRFKKIENINLALSFAEKLGGKV-VLFEPEDLVEGPKLIlGVIWTLI 99

                   ..
gi 194376642    83 AL 84
Cdd:smart00033 100 SL 101

calponin homology (CH) domain found in LIM domain only protein 7 and similar proteins; This family includes LIM domain only protein 7 (LMO-7) and LIM and calponin homology domains-containing protein 1 (LIMCH1), and similar proteins. LMO-7, also called F-box only protein 20, or LOMP, is a transcription regulator for expression of many Emery-Dreifuss muscular dystrophy (EDMD)-relevant genes. It binds to alpha-actinin and AF6/afadin at adherens junctions for epithelial cell-cell adhesion. LIMCH1 acts as an actin stress fiber-associated protein that activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. It positively regulates actin stress fiber assembly and stabilizes focal adhesions, and therefore negatively regulates cell spreading and cell migration. Members of this family contain a single copy of the CH domain at the N-terminus. CH domains are actin filament (F-actin) binding motifs.

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 194376642   5 PNFQLGLKDGIILCELINKLQPGSVKKVNESSLNWPQLENIGNFIKAIQAYGMKPHDIFEANDLFENGN 73
Cdd:cd21208   20 DDFRESLEDGILLCELINAIKPGSIKKINRLPTPIAGLDNLNLFLKACEDLGLKDSQLFDPTDLQDLSN 88

calponin homology (CH) domain found in Arabidopsis thaliana Kinesin-like KIN-14 protein family; Kinesins are microtubule-dependent molecular motors that play important roles in intracellular transport and in cell division. This family includes a group of kinesin-like proteins belonging to KIN-14 protein family. They all contain a single copy of the CH domain at the N-terminus. CH domains are actin filament (F-actin) binding motifs.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194376642   5 PNFQLGLKDGIILCELINKLQPGSVKKVNESSLNWPQ--------LENIGNFIKAIQAYGMKphdIFEANDL--FENGNM 74
Cdd:cd21203   24 EEFRLCLRDGVVLCKLLNKLQPGAVPKVVESPDDPDGaagsafqyFENVRNFLVAIEEMGLP---TFEASDLeqGGGGSR 100

                         90
                 ....*....|
gi 194376642  75 TQVQTTLVAL 84
Cdd:cd21203  101 PRVVDCILAL 110

calponin homology (CH) domain found in beta-Pak Interactive eXchange factor; Beta-Pak Interactive eXchange factor (beta-PIX), also called PAK-interacting exchange factor beta, Rho guanine nucleotide exchange factor 7 (ARHGEF7), p85, or Cool (Cloned out of Library)-1, activates small GTPases by exchanging bound GDP for free GTP. It acts as a GEF for both Cdc42 and Rac1, and plays important roles in regulating neuroendocrine exocytosis, focal adhesion maturation, cell migration, synaptic vesicle localization, and insulin secretion. Beta-PIX contains a single copy of the CH domain at its N-terminus. CH domains are actin filament (F-actin) binding motifs.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 194376642   7 FQLGLKDGIILCELINKLQPGSVKKV-NESSLNWPQLENIGNFIKAIQAYGMkphDIFEANDLFENGNMTQVQTTLVAL 84
Cdd:cd21266   29 LQASLKDGVVLCRLLERLLPGSIDKVyPEPRTESECLSNIREFLRGCGALRL---ETFDANDLYQGQNFNKVLSSLVAL 104

calponin homology (CH) domain found in the IQ motif containing GTPase activating protein family; Members of the IQ motif containing GTPase activating protein (IQGAP) family are associated with the Ras GTP-binding protein and act as essential regulators of cytoskeletal function. There are three known IQGAP family members: IQGAP1, IQGAP2, and IQGAP3. They are multi-domain molecules having a calponin-homology (CH) domain which binds F-actin, IQGAP-specific repeats, a single WW domain, four IQ motifs that mediate interactions with calmodulin, and a RasGAP related domain that binds active Rho family GTPases. IQGAP1 negatively regulates Ras family GTPases by stimulating their intrinsic GTPase activity. It lacks GAP activity. Both IQGAP1 and IQGAP2 specifically bind to Cdc42 and Rac1, but not to RhoA. Despite similarities to part of the sequence of RasGAP, neither IQGAP1 nor IQGAP2 interacts with Ras. IQGAP3 regulates the organization of the cytoskeleton under the regulation of Rac1 and Cdc42 in neuronal cells. The depletion of IQGAP3 is shown to impair neurite or axon outgrowth in neuronal cells with disorganized cytoskeleton.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194376642   6 NFQLGLKDGIILCELINKLQPGSV--KKVNESSLNWPQLENIGNFIKAIQAYGMKPHDIFEANDLFENGNMTQVQTTLVA 83
Cdd:cd21206   30 EFEEELRNGVVLAKLANKFAPKLVplKKIYDVGLQFRHTDNINHFLRALKKIGLPKIFHFETTDLYEKKNIPKVIYCLHA 109

                 ....*....
gi 194376642  84 LAGLAKTKG 92
Cdd:cd21206  110 LSLLLFKLG 118

calponin homology (CH) domain found in alpha-Pak Interactive eXchange factor; Alpha-Pak Interactive eXchange factor (alpha-PIX), also called PAK-interacting exchange factor alpha, Rho guanine nucleotide exchange factor 6 (ARHGEF6), Rac/Cdc42 guanine nucleotide exchange factor 6, or Cool (Cloned out of Library)-2, activates small GTPases by exchanging bound GDP for free GTP. It acts as a GEF for both Cdc42 and Rac1, and is localized in dendritic spines where it regulates spine morphogenesis. It controls dendritic length and spine density in the hippocampus. Mutations in the ARHGEF6 gene cause X-linked intellectual disability in humans. Alpha-PIX contains a single copy of the CH domain at its N-terminus. CH domains are actin filament (F-actin) binding motifs.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 194376642  11 LKDGIILCELINKLQPGSVKKV-----NESSLnwpqLENIGNFIKAIQAYGMkphDIFEANDLFENGNMTQVQTTLVAL 84
Cdd:cd21265   35 LKDGVVLCKLIERLLPGSVEKYclepkTEADC----IGNIKEFLKGCAALKV---ETFEPDDLYTGENFSKVLSTLLAV 106

calponin homology (CH) domain found in the leucine-rich repeat and calponin homology domain-containing protein family; The leucine-rich repeat and calponin homology domain-containing protein (LRCH) family includes LRCH1-4. LRCH1, also called calponin homology domain-containing protein 1, or neuronal protein 81 (NP81), acts as a negative regulator of GTPase Cdc42 by sequestering Cdc42-guanine exchange factor DOCK8. LRCH2 may play a role in the organization of the cytoskeleton. LRCH3 is part of the DISP complex and may regulate the association of septins with actin and thereby regulate the actin cytoskeleton. LRCH4, also called leucine-rich repeat neuronal protein 4, or leucine-rich neuronal protein, acts as a novel Toll-like receptor (TLR) accessory protein that regulates the innate immune response. Members of this family contain a single copy of the CH domain at the C-terminus. CH domains are actin filament (F-actin) binding motifs.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194376642  11 LKDGIILCELINKLQPGSVKKVNESSLNWPQL------ENIGNFIKAIQAYGMKPHDIFEANDLFENGNMTQVQTTLVAL 84
Cdd:cd21205   26 LMDGVVLCHLANHVRPRSVPSIHVPSPAVPKLsmakcrRNVENFLEACRKLGVPEERLCSPGDILEEKGLVRVAVTVQAL 105

calponin homology (CH) domain found in VAV1 protein; VAV1 is expressed predominantly in the hematopoietic system and it plays an important role in the development and activation of B and T cells. It is activated by tyrosine phosphorylation to function as a guanine nucleotide exchange factor (GEF) for Rho GTPases following cell surface receptor activation, triggering various effects such as cytoskeletal reorganization, transcription regulation, cell cycle progression, and calcium mobilization. It also serves as a scaffold protein and has been shown to interact with Ku70, Socs1, Janus kinase 2, SIAH2, S100B, Abl gene, ZAP-70, SLP76, and Syk, among others. VAV proteins contain several domains that enable their function: N-terminal calponin homology (CH), acidic, RhoGEF (also called Dbl-homologous or DH), Pleckstrin Homology (PH), C1 (zinc finger), SH2, and two SH3 domains. This model corresponds to the CH domain, an actin-binding domain which is present as a single copy in VAV1 protein.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194376642  11 LKDGIILCELINKLQPGSVkKVNESSLNwPQ------LENIGNFIKAIQ-AYGMKPHDIFEANDLFENGNMTQVQTTLVA 83
Cdd:cd21262   36 LRDGVLLCQLLNNLLPHAV-NLREINLR-PQmsqflcLKNIRTFLSTCCeKFGLRKSELFEAFDLFDVRDFGKVIDTLSI 113

                 ..
gi 194376642  84 LA 85
Cdd:cd21262  114 LS 115

Calponin family repeat;

                          10        20
                  ....*....|....*....|....*
gi 194376642  163 ISLQMGTNKGASQAGMLAPGTRRDI 187
Cdd:pfam00402   1 IGLQMGTNKGASQSGMTAFGAVRHI 25

Protein involved in regulation of cellular morphogenesis/cytokinesis [Cell division and chromosome partitioning / Signal transduction mechanisms];

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194376642    7 FQLGLKDGIILCELINKLQPGSVKKV-NESSLNWPQLENIGNFIKAIQAYGMKPHDIFEANDLFENGNMTQVQTTLVALA 85
Cdd:COG5261    66 FEDSLRNGVFLAKLTQRFNPDLTTVIfPADKLQFRHTDNINAFLDLIEHVGLPESFHFELQDLYEKKNIPKVIYCIHALI 145

                  ....*..
gi 194376642   86 GLAKTKG 92
Cdd:COG5261   146 SMLSWPG 152

calponin homology (CH) domain found in the growth arrest-specific protein 2 family; The growth arrest-specific protein 2 (GAS-2) family includes GAS-2, and GAS-2 like proteins, GAS2L1-3. GAS-2 may play a role in apoptosis by acting as a cell death substrate for caspases. GAS2L1 (also called GAS2-related protein on chromosome 22 or growth arrest-specific protein 2-like 1) and GAS2L2 (also called GAS2-related protein on chromosome 17 or growth arrest-specific protein 2-like 2) may be involved in the cross-linking of microtubules and microfilaments. GAS2L3, also called GAS2-like protein 3, is a cytoskeletal linker protein that may promote and stabilize the formation of the actin and microtubule network. Members of this family contain a single copy of the CH domain at the N-terminal region. CH domains are actin filament (F-actin) binding motifs.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194376642   6 NFQLGLKDGIILCELINKLQ--------------PGSVKKV----NESSLNWPQLENIGNFIKAIQAYGMKPHDIFEAND 67
Cdd:cd21204   27 NFLDELRNGVVLCQLAQKIQeaaekareagkkngPPPSYKLkcneNAKPGSFFARDNVANFLRWCRKLGVDEVLLFESED 106

                         90       100
                 ....*....|....*....|....*
gi 194376642  68 LFENGNMTQVQTTLVALAGLAKTKG 92
Cdd:cd21204  107 LVLHKNPRQVLLCLLELARIAARYG 131

calponin homology (CH) domain found in leucine-rich repeat and calponin homology domain-containing protein 4; Leucine-rich repeat and calponin homology domain-containing protein 4 (LRCH4), also called leucine-rich repeat neuronal protein 4, or leucine-rich neuronal protein, acts as a novel Toll-like receptor (TLR) accessory protein that regulates the innate immune response. LRCH4 contains a single copy of the CH domain at the C-terminus. CH domains are actin filament (F-actin) binding motifs.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194376642  11 LKDGIILCELINKLQPGSVKKVNESSLNWPQL------ENIGNFIKAIQAYGMKPHDIFEANDLFENGNMTQVQTTLVAL 84
Cdd:cd21273   29 LSNGAVLCQLANQLRPRSVSIIHVPSPAVPKLskakcrKNVENFIEACRKMGVPEVDLCSPSDVLLQGPAAVLRTVLALL 108

                 .
gi 194376642  85 A 85
Cdd:cd21273  109 A 109

first calponin homology (CH) domain found in Drosophila melanogaster protein jitterbug and similar proteins; Protein jitterbug (Jbug) is an actin-meshwork organizing protein. It is required to maintain the shape and cell orientation of the Drosophila notum epithelium during flight muscle attachment to tendon cells. Jbug contains three copies of the CH domain. This model corresponds to the first CH domain. CH domains are actin filament (F-actin) binding motifs.

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 194376642   6 NFQLGLKDGIILCELINKLQPGSVKKVNESSLNWPQ-LENIGNFIKAIQAYGMK-----PHDIFEAN 66
Cdd:cd21227   26 DLATDLEDGVKLIALVEILQGRKLGRVIKKPLNQHQkLENVTLALKAMAEDGIKlvnigNEDIVNGN 92