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Conserved domains on  [gi|194380688|dbj|BAG58497|]
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unnamed protein product [Homo sapiens]

Protein Classification

armadillo/beta-catenin-like repeat-containing protein( domain architecture ID 1000979)

armadillo/beta-catenin-like repeat-containing protein similar to Saccharomyces cerevisiae vacuolar protein 8 that functions in both vacuole inheritance and protein targeting from the cytoplasm to vacuole

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SRP1 super family cl34886
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
33-522 0e+00

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


The actual alignment was detected with superfamily member COG5064:

Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 619.60  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194380688  33 IQLRKQKREQQLFKRRNVELINEEAamfdsllMDSYVSSTTGESVITREMVEMLFSDDSDLQLATTQKFRKLLSKEPSPP 112
Cdd:COG5064   34 VELRKQKREELLNKRRNLADVSEEA-------ESSFIPMEQQFYSELPQLTQQLFSDDIEQQLQAVYKFRKLLSKETSPP 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194380688 113 IDEVINTPrVVDRFVEFLKRNENCTLQFEAAWALTNIASGTSQQTKIVIEAGAVPIFIELLNSDFEDVQEQAVWALGNIA 192
Cdd:COG5064  107 IQPVIDAG-VVPRFVEFMDEIQRDMLQFEAAWALTNIASGTTQQTKVVVDAGAVPLFIQLLSSTEDDVREQAVWALGNIA 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194380688 193 GDSSVCRDYVLNCSILNPLLTLLTKSTR-LTMTRNAVWALSNLCRGKNPPPEFAKVSPCLPVLSRLLFSSDSDLLADACW 271
Cdd:COG5064  186 GDSEGCRDYVLQCGALEPLLGLLLSSAIhISMLRNATWTLSNLCRGKNPPPDWSNISQALPILAKLIYSRDPEVLVDACW 265

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194380688 272 ALSYLSDGPNEKIQAVIDSGVCRRLVELLMHNDYKVASPALRAVGSIVTGDDIQTQVILNCSALPCLLHLLSSPKESIRK 351
Cdd:COG5064  266 AISYLSDGPNEKIQAVLDVGIPGRLVELLSHESAKIQTPALRSVGNIVTGSDDQTQVIINCGALKAFRSLLSSPKENIRK 345

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194380688 352 EACWTISNITAGNRAQIQAVIDANIFPVLIEILQKAEFRTRKEAAWAITNATSGGT--PEQIRYLVSLGCIKPLCDLLTV 429
Cdd:COG5064  346 EACWTISNITAGNTEQIQAVIDANLIPPLIHLLSSAEYKIKKEACWAISNATSGGLnrPDIIRYLVSQGFIKPLCDLLDV 425

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194380688 430 MDSKIVQVALNGLENILRLGEQEGKRSGSGVNPYCGLIEEAYGLDKIEFLQSHENQEIYQKAFDLIEHYFGVEDDDSSLA 509
Cdd:COG5064  426 VDNKIIEVALDAIENILKVGEQDRLRYGKNINIYAVYVEKAGGMDAIHGLQDSVNRTIYDKAYSIIEKFFGEEDAVDELA 505

                        490       500
                 ....*....|....*....|.
gi 194380688 510 PQV--------DETQQQFIFQ 522
Cdd:COG5064  506 PETagntftfgSNVNQQGNFN 526
 
Name Accession Description Interval E-value
SRP1 COG5064
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
33-522 0e+00

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 619.60  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194380688  33 IQLRKQKREQQLFKRRNVELINEEAamfdsllMDSYVSSTTGESVITREMVEMLFSDDSDLQLATTQKFRKLLSKEPSPP 112
Cdd:COG5064   34 VELRKQKREELLNKRRNLADVSEEA-------ESSFIPMEQQFYSELPQLTQQLFSDDIEQQLQAVYKFRKLLSKETSPP 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194380688 113 IDEVINTPrVVDRFVEFLKRNENCTLQFEAAWALTNIASGTSQQTKIVIEAGAVPIFIELLNSDFEDVQEQAVWALGNIA 192
Cdd:COG5064  107 IQPVIDAG-VVPRFVEFMDEIQRDMLQFEAAWALTNIASGTTQQTKVVVDAGAVPLFIQLLSSTEDDVREQAVWALGNIA 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194380688 193 GDSSVCRDYVLNCSILNPLLTLLTKSTR-LTMTRNAVWALSNLCRGKNPPPEFAKVSPCLPVLSRLLFSSDSDLLADACW 271
Cdd:COG5064  186 GDSEGCRDYVLQCGALEPLLGLLLSSAIhISMLRNATWTLSNLCRGKNPPPDWSNISQALPILAKLIYSRDPEVLVDACW 265

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194380688 272 ALSYLSDGPNEKIQAVIDSGVCRRLVELLMHNDYKVASPALRAVGSIVTGDDIQTQVILNCSALPCLLHLLSSPKESIRK 351
Cdd:COG5064  266 AISYLSDGPNEKIQAVLDVGIPGRLVELLSHESAKIQTPALRSVGNIVTGSDDQTQVIINCGALKAFRSLLSSPKENIRK 345

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194380688 352 EACWTISNITAGNRAQIQAVIDANIFPVLIEILQKAEFRTRKEAAWAITNATSGGT--PEQIRYLVSLGCIKPLCDLLTV 429
Cdd:COG5064  346 EACWTISNITAGNTEQIQAVIDANLIPPLIHLLSSAEYKIKKEACWAISNATSGGLnrPDIIRYLVSQGFIKPLCDLLDV 425

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194380688 430 MDSKIVQVALNGLENILRLGEQEGKRSGSGVNPYCGLIEEAYGLDKIEFLQSHENQEIYQKAFDLIEHYFGVEDDDSSLA 509
Cdd:COG5064  426 VDNKIIEVALDAIENILKVGEQDRLRYGKNINIYAVYVEKAGGMDAIHGLQDSVNRTIYDKAYSIIEKFFGEEDAVDELA 505

                        490       500
                 ....*....|....*....|.
gi 194380688 510 PQV--------DETQQQFIFQ 522
Cdd:COG5064  506 PETagntftfgSNVNQQGNFN 526
Arm_3 pfam16186
Atypical Arm repeat; This atypical Arm repeat appears at the very C-terminus of eukaryotic ...
 466-511 2.24e-19

Atypical Arm repeat; This atypical Arm repeat appears at the very C-terminus of eukaryotic proteins such as importin subunit alpha-2, as the last of the repeating units.


Pssm-ID: 465050 [Multi-domain]  Cd Length: 49  Bit Score: 81.48  E-value: 2.24e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 194380688  466 LIEEAYGLDKIEFLQSHENQEIYQKAFDLIEHYFGVED--DDSSLAPQ 511
Cdd:pfam16186   2 LIEEAGGLDKIEALQNHENEEIYKKAYKIIEKYFSDEEeeDDENLAPE 49
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 153-192 6.50e-10

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 54.36  E-value: 6.50e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 194380688   153 TSQQTKIVIEAGAVPIFIELLNSDFEDVQEQAVWALGNIA 192
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLS 40
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 80-234 5.26e-03

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 39.70  E-value: 5.26e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194380688   80 REMVEMLFSDDSDLQ------LATTQKFRKLLSKepSPPIDEVINTprvvdrfVEFLKRNENCTLQFEAAWALTNIASGT 153
Cdd:PLN03200  612 RTLIQLLSSSKEETQekaasvLADIFSSRQDLCE--SLATDEIINP-------CIKLLTNNTEAVATQSARALAALSRSI 682

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194380688  154 SQQTKI-VIEAGAVPIFIELLNSDFEDVQEQAVWALGNIAGDSSVCRDyVLNCSILNPLLTLLTKSTrLTMTRNAVWALS 232
Cdd:PLN03200  683 KENRKVsYAAEDAIKPLIKLAKSSSIEVAEQAVCALANLLSDPEVAAE-ALAEDIILPLTRVLREGT-LEGKRNAARALA 760


                  ..
gi 194380688  233 NL 234
Cdd:PLN03200  761 QL 762
 
Name Accession Description Interval E-value
SRP1 COG5064
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
33-522 0e+00

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 619.60  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194380688  33 IQLRKQKREQQLFKRRNVELINEEAamfdsllMDSYVSSTTGESVITREMVEMLFSDDSDLQLATTQKFRKLLSKEPSPP 112
Cdd:COG5064   34 VELRKQKREELLNKRRNLADVSEEA-------ESSFIPMEQQFYSELPQLTQQLFSDDIEQQLQAVYKFRKLLSKETSPP 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194380688 113 IDEVINTPrVVDRFVEFLKRNENCTLQFEAAWALTNIASGTSQQTKIVIEAGAVPIFIELLNSDFEDVQEQAVWALGNIA 192
Cdd:COG5064  107 IQPVIDAG-VVPRFVEFMDEIQRDMLQFEAAWALTNIASGTTQQTKVVVDAGAVPLFIQLLSSTEDDVREQAVWALGNIA 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194380688 193 GDSSVCRDYVLNCSILNPLLTLLTKSTR-LTMTRNAVWALSNLCRGKNPPPEFAKVSPCLPVLSRLLFSSDSDLLADACW 271
Cdd:COG5064  186 GDSEGCRDYVLQCGALEPLLGLLLSSAIhISMLRNATWTLSNLCRGKNPPPDWSNISQALPILAKLIYSRDPEVLVDACW 265

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194380688 272 ALSYLSDGPNEKIQAVIDSGVCRRLVELLMHNDYKVASPALRAVGSIVTGDDIQTQVILNCSALPCLLHLLSSPKESIRK 351
Cdd:COG5064  266 AISYLSDGPNEKIQAVLDVGIPGRLVELLSHESAKIQTPALRSVGNIVTGSDDQTQVIINCGALKAFRSLLSSPKENIRK 345

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194380688 352 EACWTISNITAGNRAQIQAVIDANIFPVLIEILQKAEFRTRKEAAWAITNATSGGT--PEQIRYLVSLGCIKPLCDLLTV 429
Cdd:COG5064  346 EACWTISNITAGNTEQIQAVIDANLIPPLIHLLSSAEYKIKKEACWAISNATSGGLnrPDIIRYLVSQGFIKPLCDLLDV 425

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194380688 430 MDSKIVQVALNGLENILRLGEQEGKRSGSGVNPYCGLIEEAYGLDKIEFLQSHENQEIYQKAFDLIEHYFGVEDDDSSLA 509
Cdd:COG5064  426 VDNKIIEVALDAIENILKVGEQDRLRYGKNINIYAVYVEKAGGMDAIHGLQDSVNRTIYDKAYSIIEKFFGEEDAVDELA 505

                        490       500
                 ....*....|....*....|.
gi 194380688 510 PQV--------DETQQQFIFQ 522
Cdd:COG5064  506 PETagntftfgSNVNQQGNFN 526
Arm_3 pfam16186
Atypical Arm repeat; This atypical Arm repeat appears at the very C-terminus of eukaryotic ...
 466-511 2.24e-19

Atypical Arm repeat; This atypical Arm repeat appears at the very C-terminus of eukaryotic proteins such as importin subunit alpha-2, as the last of the repeating units.


Pssm-ID: 465050 [Multi-domain]  Cd Length: 49  Bit Score: 81.48  E-value: 2.24e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 194380688  466 LIEEAYGLDKIEFLQSHENQEIYQKAFDLIEHYFGVED--DDSSLAPQ 511
Cdd:pfam16186   2 LIEEAGGLDKIEALQNHENEEIYKKAYKIIEKYFSDEEeeDDENLAPE 49
IBB pfam01749
Importin beta binding domain; This family consists of the importin alpha (karyopherin alpha), ...
 10-99 3.83e-18

Importin beta binding domain; This family consists of the importin alpha (karyopherin alpha), importin beta (karyopherin beta) binding domain. The domain mediates formation of the importin alpha beta complex; required for classical NLS import of proteins into the nucleus, through the nuclear pore complex and across the nuclear envelope. Also in the alignment is the NLS of importin alpha which overlaps with the IBB domain.


Pssm-ID: 460311 [Multi-domain]  Cd Length: 79  Bit Score: 78.73  E-value: 3.83e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194380688   10 RMKSYKNNALNPEEMRRRREEEGIQLRKQKREQQLFKRRNVELINEEAAMFDSLLmdsyvssttgeSVITREMVEMLFSD 89
Cdd:pfam01749   1 RRKSFKNKGKDADELRRRREEVQVELRKQKREEQLLKRRNVGAPSSSSSSAESQL-----------LESLPEMVQGVNSD 69

                          90
                  ....*....|
gi 194380688   90 DSDLQLATTQ 99
Cdd:pfam01749  70 DPELQLEATQ 79
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 153-192 1.09e-11

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 59.39  E-value: 1.09e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 194380688  153 TSQQTKIVIEAGAVPIFIELLNSDFEDVQEQAVWALGNIA 192
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLA 40
HEAT COG1413
HEAT repeat [General function prediction only];
225-399 4.12e-11

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 60.80  E-value: 4.12e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194380688 225 RNAVWALSNLcrgknpppefaKVSPCLPVLSRLLFSSDSDLLADACWALSYLSDgpnekIQAVidsgvcRRLVELLMHND 304
Cdd:COG1413    3 RAAARALGRL-----------GDPAAVPALIAALADEDPDVRAAAARALGRLGD-----PRAV------PALLEALKDPD 60

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194380688 305 YKVASPALRAVGSIvtGDDiqtqvilncSALPCLLHLLSSPKESIRKEACWTISNITagnraqiqaviDANIFPVLIEIL 384
Cdd:COG1413   61 PEVRAAAAEALGRI--GDP---------EAVPALIAALKDEDPEVRRAAAEALGRLG-----------DPAAVPALLEAL 118

                        170
                 ....*....|....*
gi 194380688 385 QKAEFRTRKEAAWAI 399
Cdd:COG1413  119 KDPDWEVRRAAARAL 133
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 325-362 3.52e-10

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 55.15  E-value: 3.52e-10
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 194380688  325 QTQVILNCSALPCLLHLLSSPKESIRKEACWTISNITA 362
Cdd:pfam00514   4 NKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 153-192 6.50e-10

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 54.36  E-value: 6.50e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 194380688   153 TSQQTKIVIEAGAVPIFIELLNSDFEDVQEQAVWALGNIA 192
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLS 40
HEAT COG1413
HEAT repeat [General function prediction only];
142-318 1.50e-09

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 56.18  E-value: 1.50e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194380688 142 AAWALTNIASgtsqqtkivieAGAVPIFIELLNSDFEDVQEQAVWALGNIAGDSSVcrdyvlncsilNPLLTLLtKSTRL 221
Cdd:COG1413    5 AARALGRLGD-----------PAAVPALIAALADEDPDVRAAAARALGRLGDPRAV-----------PALLEAL-KDPDP 61

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194380688 222 TMTRNAVWALSNLcrgKNPPPefakvspcLPVLSRLLFSSDSDLLADACWALSYLSDgpnekiQAVIDsgvcrRLVELLM 301
Cdd:COG1413   62 EVRAAAAEALGRI---GDPEA--------VPALIAALKDEDPEVRRAAAEALGRLGD------PAAVP-----ALLEALK 119

                        170
                 ....*....|....*..
gi 194380688 302 HNDYKVASPALRAVGSI 318
Cdd:COG1413  120 DPDWEVRRAAARALGRL 136
HEAT COG1413
HEAT repeat [General function prediction only];
180-360 1.73e-08

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 53.09  E-value: 1.73e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194380688 180 VQEQAVWALGNIAGDSSVcrdyvlncsilnPLLTLLTKSTRLTMTRNAVWALSNLcrgknpppefaKVSPCLPVLSRLLF 259
Cdd:COG1413    1 VRRAAARALGRLGDPAAV------------PALIAALADEDPDVRAAAARALGRL-----------GDPRAVPALLEALK 57

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194380688 260 SSDSDLLADACWALSYLSDgpnekiQAVIDsgvcrRLVELLMHNDYKVASPALRAVGSIvtGDDiqtqvilncSALPCLL 339
Cdd:COG1413   58 DPDPEVRAAAAEALGRIGD------PEAVP-----ALIAALKDEDPEVRRAAAEALGRL--GDP---------AAVPALL 115

                        170       180
                 ....*....|....*....|.
gi 194380688 340 HLLSSPKESIRKEACWTISNI 360
Cdd:COG1413  116 EALKDPDWEVRRAAARALGRL 136
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 322-362 3.39e-08

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 49.35  E-value: 3.39e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 194380688   322 DDIQTQVILNCSALPCLLHLLSSPKESIRKEACWTISNITA 362
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 138-191 4.75e-08

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 49.67  E-value: 4.75e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 194380688  138 LQFEAAWALTNIASGTSQQTKIVIEAgAVPIFIELLNSDFEDVQEQAVWALGNI 191
Cdd:pfam13513   3 VREAAALALGSLAEGGPDLLAPAVPE-LLPALLPLLNDDSDLVREAAAWALGRL 55
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 364-404 1.07e-07

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 48.22  E-value: 1.07e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 194380688  364 NRAQIQAVIDANIFPVLIEILQKAEFRTRKEAAWAITNATS 404
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 407-447 8.20e-07

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 45.52  E-value: 8.20e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 194380688  407 TPEQIRYLVSLGCIKPLCDLLTVMDSKIVQVALNGLENILR 447
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 195-236 9.32e-07

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 45.52  E-value: 9.32e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 194380688  195 SSVCRDYVLNCSILNPLLTLLtKSTRLTMTRNAVWALSNLCR 236
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLL-SSPDEEVQEEAAWALSNLAA 41
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 123-232 4.68e-06

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 45.02  E-value: 4.68e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194380688  123 VDRFVEFLKRNENCTLQFEAAWALTNIASgtsqqtkivieAGAVPIFIELLNSDFEDVQEQAVWALGNIaGDSSVcrdyv 202
Cdd:pfam13646   1 LPALLQALLRDPDPEVRAAAIRALGRIGD-----------PEAVPALLELLKDEDPAVRRAAAEALGKI-GDPEA----- 63

                          90       100       110
                  ....*....|....*....|....*....|
gi 194380688  203 lncsiLNPLLTLLTKSTRLTMTRNAVWALS 232
Cdd:pfam13646  64 -----LPALLELLRDDDDDVVRAAAAEALA 88
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 280-320 1.56e-05

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 42.06  E-value: 1.56e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 194380688  280 PNEKIQAVIDSGVCRRLVELLMHNDYKVASPALRAVGSIVT 320
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 364-404 1.71e-05

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 42.03  E-value: 1.71e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 194380688   364 NRAQIQAVIDANIFPVLIEILQKAEFRTRKEAAWAITNATS 404
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 239-278 1.89e-05

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 41.67  E-value: 1.89e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 194380688  239 NPPPEFAKVSPCLPVLSRLLFSSDSDLLADACWALSYLSD 278
Cdd:pfam00514   2 PENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
HEAT COG1413
HEAT repeat [General function prediction only];
117-192 2.90e-05

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 43.85  E-value: 2.90e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 194380688 117 INTPRVVDRFVEFLKrNENCTLQFEAAWALTNIASgtsqqtkivieAGAVPIFIELLNSDFEDVQEQAVWALGNIA 192
Cdd:COG1413   74 IGDPEAVPALIAALK-DEDPEVRRAAAEALGRLGD-----------PAAVPALLEALKDPDWEVRRAAARALGRLG 137
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 311-360 6.91e-05

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 40.43  E-value: 6.91e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 194380688  311 ALRAVGSI--VTGDDIQTQVIlncSALPCLLHLLSSPKESIRKEACWTISNI 360
Cdd:pfam13513   7 AALALGSLaeGGPDLLAPAVP---ELLPALLPLLNDDSDLVREAAAWALGRL 55
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 407-445 1.30e-04

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 39.33  E-value: 1.30e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 194380688   407 TPEQIRYLVSLGCIKPLCDLLTVMDSKIVQVALNGLENI 445
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNL 39
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 109-151 2.17e-04

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 38.59  E-value: 2.17e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 194380688  109 PSPPIDEVINtPRVVDRFVEFLKrNENCTLQFEAAWALTNIAS 151
Cdd:pfam00514   1 SPENKQAVIE-AGAVPPLVRLLS-SPDEEVQEEAAWALSNLAA 41
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 280-319 2.88e-04

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 38.56  E-value: 2.88e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 194380688   280 PNEKIQAVIDSGVCRRLVELLMHNDYKVASPALRAVGSIV 319
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLS 40
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 180-234 1.96e-03

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 36.58  E-value: 1.96e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 194380688  180 VQEQAVWALGNIA-GDSSVCRDYVLNcsILNPLLTLLTKSTRLTMtRNAVWALSNL 234
Cdd:pfam13513   3 VREAAALALGSLAeGGPDLLAPAVPE--LLPALLPLLNDDSDLVR-EAAAWALGRL 55
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 296-396 3.91e-03

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 36.55  E-value: 3.91e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194380688  296 LVELLM-HNDYKVASPALRAVGSIvtGDDiqtqvilncSALPCLLHLLSSPKESIRKEACWTISNItaGNRAQIqavida 374
Cdd:pfam13646   4 LLQALLrDPDPEVRAAAIRALGRI--GDP---------EAVPALLELLKDEDPAVRRAAAEALGKI--GDPEAL------ 64

                          90       100
                  ....*....|....*....|..
gi 194380688  375 nifPVLIEILQKAEFRTRKEAA 396
Cdd:pfam13646  65 ---PALLELLRDDDDDVVRAAA 83
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 80-234 5.26e-03

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 39.70  E-value: 5.26e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194380688   80 REMVEMLFSDDSDLQ------LATTQKFRKLLSKepSPPIDEVINTprvvdrfVEFLKRNENCTLQFEAAWALTNIASGT 153
Cdd:PLN03200  612 RTLIQLLSSSKEETQekaasvLADIFSSRQDLCE--SLATDEIINP-------CIKLLTNNTEAVATQSARALAALSRSI 682

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194380688  154 SQQTKI-VIEAGAVPIFIELLNSDFEDVQEQAVWALGNIAGDSSVCRDyVLNCSILNPLLTLLTKSTrLTMTRNAVWALS 232
Cdd:PLN03200  683 KENRKVsYAAEDAIKPLIKLAKSSSIEVAEQAVCALANLLSDPEVAAE-ALAEDIILPLTRVLREGT-LEGKRNAARALA 760


                  ..
gi 194380688  233 NL 234
Cdd:PLN03200  761 QL 762
HEAT COG1413
HEAT repeat [General function prediction only];
307-445 5.55e-03

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 37.30  E-value: 5.55e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194380688 307 VASPALRAVGSIvtGDDiqtqvilncSALPCLLHLLSSPKESIRKEACWTISNITagnraqiqaviDANIFPVLIEILQK 386
Cdd:COG1413    1 VRRAAARALGRL--GDP---------AAVPALIAALADEDPDVRAAAARALGRLG-----------DPRAVPALLEALKD 58

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 194380688 387 AEFRTRKEAAWAITNAtsgGTPEQirylvslgcIKPLCDLLTVMDSKIVQVALNGLENI 445
Cdd:COG1413   59 PDPEVRAAAAEALGRI---GDPEA---------VPALIAALKDEDPEVRRAAAEALGRL 105
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 253-368 5.59e-03

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 39.70  E-value: 5.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194380688  253 VLSRLLFSSDSDLLADACWALSYLSDGPNEKIQAVIDSGVCRRLVELLMH-NDYKVASPALRAVGSIVTGDDIQTQVILN 331
Cdd:PLN03200  193 ILVKLLSSGNSDAQANAASLLARLMMAFESSISKVLDAGAVKQLLKLLGQgNEVSVRAEAAGALEALSSQSKEAKQAIAD 272

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 194380688  332 CSALPCLLHLLSSP-KESIRKE--------ACWTISNITAGNRAQI 368
Cdd:PLN03200  273 AGGIPALINATVAPsKEFMQGEfaqalqenAMGALANICGGMSALI 318
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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