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Conserved domains on  [gi|194387964|dbj|BAG61395|]
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unnamed protein product [Homo sapiens]

Protein Classification

pyruvate kinase( domain architecture ID 10084586)

pyruvate kinase catalyzes the phosphorylation of pyruvate to form phosphoenolpyruvate and functions in regulating glycolysis

CATH:  2.40.33.10|3.20.20.60|3.40.1380.20
EC:  2.7.1.40
Gene Ontology:  GO:0004743|GO:0006096|GO:0005524|GO:0030955|GO:0000287
PubMed:  31342570
SCOP:  4003255|4002474|4000500

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Pyruvate_Kinase cd00288
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ...
 42-510 0e+00

Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.


:

Pssm-ID: 238178 [Multi-domain]  Cd Length: 480  Bit Score: 789.20  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964  42 ARNTGIICTIGPASRSVETLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATESFASDPII----KG--------SGT 109
Cdd:cd00288    1 LRRTKIVCTIGPATDSVENLKKLIKAGMNVARMNFSHGSHEYHQSRIDNVREAAEKTGGPVAIaldtKGpeirtglfKGG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964 110 AEVELKKGSTLKITLDNAyMEKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKQKGAD-FLVTEVENGGSLGSKKG 188
Cdd:cd00288   81 KDISLKAGDKFLVTTDPA-AKKGTKEKIYVDYKNLTKDVSPGNTILVDDGLLSLKVLSKDDDkTLVCEVLNGGVLGSRKG 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964 189 VNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVLGEKGKNIKIISKIENHEGVRRFDEILEASD 268
Cdd:cd00288  160 VNLPGTDVDLPALSEKDKADLRFGVEQGVDMIFASFVRKASDVLEIREVLGEKGKDIKIIAKIENQEGVNNFDEILEASD 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964 269 GIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKG 348
Cdd:cd00288  240 GIMVARGDLGVEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETAKG 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964 349 DYPLEAVRMQHLIAREAEAAMFHRKLFEELVRASSHSTDLMEAMAMGSVEASYKCLAAALIVLTESGRSAHQVARYRPRA 428
Cdd:cd00288  320 KYPVEAVKAMARICLEAEKALSHRVLFNEMRRLTPRPTSTTEAVAMSAVRAAFELGAKAIVVLTTSGRTARLVSKYRPNA 399

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964 429 PIIAVTRNPQTARQAHLYRGIFPVLCKDPVQEaWAEDVDLRVNFAMNVGKARGFFKKGDVVIVLTGWRPGSGFTNTMRVV 508
Cdd:cd00288  400 PIIAVTRNEQTARQLHLYRGVYPVLFEEPKPG-WQEDTDARLKAAVNVAKEKGLLKKGDLVVVVQGWPVGSGSTNTMRIL 478


                 ..
gi 194387964 509 PV 510
Cdd:cd00288  479 TV 480
 
Name Accession Description Interval E-value
Pyruvate_Kinase cd00288
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ...
 42-510 0e+00

Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.


Pssm-ID: 238178 [Multi-domain]  Cd Length: 480  Bit Score: 789.20  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964  42 ARNTGIICTIGPASRSVETLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATESFASDPII----KG--------SGT 109
Cdd:cd00288    1 LRRTKIVCTIGPATDSVENLKKLIKAGMNVARMNFSHGSHEYHQSRIDNVREAAEKTGGPVAIaldtKGpeirtglfKGG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964 110 AEVELKKGSTLKITLDNAyMEKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKQKGAD-FLVTEVENGGSLGSKKG 188
Cdd:cd00288   81 KDISLKAGDKFLVTTDPA-AKKGTKEKIYVDYKNLTKDVSPGNTILVDDGLLSLKVLSKDDDkTLVCEVLNGGVLGSRKG 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964 189 VNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVLGEKGKNIKIISKIENHEGVRRFDEILEASD 268
Cdd:cd00288  160 VNLPGTDVDLPALSEKDKADLRFGVEQGVDMIFASFVRKASDVLEIREVLGEKGKDIKIIAKIENQEGVNNFDEILEASD 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964 269 GIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKG 348
Cdd:cd00288  240 GIMVARGDLGVEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETAKG 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964 349 DYPLEAVRMQHLIAREAEAAMFHRKLFEELVRASSHSTDLMEAMAMGSVEASYKCLAAALIVLTESGRSAHQVARYRPRA 428
Cdd:cd00288  320 KYPVEAVKAMARICLEAEKALSHRVLFNEMRRLTPRPTSTTEAVAMSAVRAAFELGAKAIVVLTTSGRTARLVSKYRPNA 399

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964 429 PIIAVTRNPQTARQAHLYRGIFPVLCKDPVQEaWAEDVDLRVNFAMNVGKARGFFKKGDVVIVLTGWRPGSGFTNTMRVV 508
Cdd:cd00288  400 PIIAVTRNEQTARQLHLYRGVYPVLFEEPKPG-WQEDTDARLKAAVNVAKEKGLLKKGDLVVVVQGWPVGSGSTNTMRIL 478


                 ..
gi 194387964 509 PV 510
Cdd:cd00288  479 TV 480
pyruv_kin TIGR01064
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of ...
 43-507 0e+00

pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of fructose-1,6-bisphosphate or similar phosphorylated sugars. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 273424 [Multi-domain]  Cd Length: 472  Bit Score: 716.37  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964   43 RNTGIICTIGPASRSVETLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATESF------ASD---PIIKGSGTA--E 111
Cdd:TIGR01064   1 RRTKIVCTIGPATNSPEMLKKLLDAGMNVARLNFSHGSHEEHGKRIENVREAAEKLgrpvaiLLDtkgPEIRTGEIKggE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964  112 VELKKGSTLKITLDNAYMEkCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKQKGADFLVTEVENGGSLGSKKGVNL 191
Cdd:TIGR01064  81 VKLKKGDKVIITTDDIKGE-GDEEKVYVDYKGLTKDVVEGDKILVDDGKISLVVVSVEGDKVICEVLNGGTLKSKKGVNL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964  192 PGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVLGEKG-KNIKIISKIENHEGVRRFDEILEASDGI 270
Cdd:TIGR01064 160 PGADVDLPALSEKDKKDLKFGVEQGVDMVAASFVRTAEDVLEVREVLGEKGaKDVKIIAKIENQEGVDNIDEIAEASDGI 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964  271 MVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDY 350
Cdd:TIGR01064 240 MVARGDLGVEIPAEEVPIAQKKMIRKCNRAGKPVITATQMLDSMIKNPRPTRAEVSDVANAVLDGTDAVMLSGETAKGKY 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964  351 PLEAVRMQHLIAREAEAAMFHRKLFEELVRASSHSTDLMEAMAMGSVEASYKCLAAALIVLTESGRSAHQVARYRPRAPI 430
Cdd:TIGR01064 320 PVEAVQMMAKIAKEAEKALAYLTNFNDRKNSDPKPSTITEAIALSAVEAAEKLDAKAIVVLTESGRTARLLSKYRPNAPI 399

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 194387964  431 IAVTRNPQTARQAHLYRGIFPVLCKDpvqeaWAEDVDLRVNFAMNVGKARGFFKKGDVVIVLTG-WRPGSGFTNTMRV 507
Cdd:TIGR01064 400 IAVTPNERVARQLALYWGVFPFLVDE-----EPSDTDARVNKALELLKEKGIVKKGDLVVVIQGgPIGGEGGTNTIRV 472
PykF COG0469
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the ...
 43-510 0e+00

Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 440237 [Multi-domain]  Cd Length: 471  Bit Score: 637.46  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964  43 RNTGIICTIGPASRSVETLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTA--------------------TESFASDP 102
Cdd:COG0469    3 RRTKIVATLGPASDSPEVLRKLIEAGMDVARLNFSHGDHEEHRERIELIREAakelgrpvailldlqgpkirTGKFKEGP 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964 103 IikgsgtaevELKKGSTLKITLDNaymEKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKQKGADFLVTEVENGGS 182
Cdd:COG0469   83 V---------ELKKGDTFTLTTDD---VEGDAERVSVTYPELPEDVKPGDRILLDDGKIELRVEEVEGDEVVCEVVNGGV 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964 183 LGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVLGEKGKNIKIISKIENHEGVRRFDE 262
Cdd:COG0469  151 LSSRKGVNLPGVGLSLPALTEKDREDLKFALELGVDFIALSFVRSAEDVLEARELLEEAGGRAPIIAKIEKPEAVENLDE 230

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964 263 ILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLS 342
Cdd:COG0469  231 IIEASDGIMVARGDLGVEIPLEEVPLIQKRIIRKARRAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLS 310

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964 343 GETAKGDYPLEAVRMQHLIAREAEAAMFHRKLFEELVRASSHSTDlmEAMAMGSVEASYKCLAAALIVLTESGRSAHQVA 422
Cdd:COG0469  311 GETAVGKYPVEAVETMARIAEEAEKSLDYRRILDRLRDEPERTIT--DAIARAAVELAEDLGAKAIVAFTESGSTARRIS 388

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964 423 RYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDpvqeawAEDVDLRVNFAMNVGKARGFFKKGDVVIVLTGWRPG-SGF 501
Cdd:COG0469  389 RYRPKVPILALTPNERTARRLALVWGVYPVLVDD------VESTDEMIEEAVEALLEEGLVKPGDLVVITAGVPVGvPGT 462


                 ....*....
gi 194387964 502 TNTMRVVPV 510
Cdd:COG0469  463 TNTLKVHRV 471
PK pfam00224
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain ...
 42-375 0e+00

Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel. The active site is found in a cleft between the two domains.


Pssm-ID: 395168 [Multi-domain]  Cd Length: 348  Bit Score: 588.95  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964   42 ARNTGIICTIGPASRSVETLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATESFASDPII----KG---------SG 108
Cdd:pfam00224   1 LRRTKIVCTIGPASNSVENLEKLIEAGANVARMNFSHGSHEYHQSRIDNVREAEEKTGGTVAIaldtKGpeirtgntkDG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964  109 TAEVELKKGSTLKITLDNAYMEKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKQKGADF-LVTEVENGGSLGSKK 187
Cdd:pfam00224  81 KKDIELKAGDEMIVSTDAKYKGACDDEMIYVDYKNIVKDVSVGGTILVDDGLLSLKVLSKDDDKtLVVEVLNGGVIGSRK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964  188 GVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVLGEKGKNIKIISKIENHEGVRRFDEILEAS 267
Cdd:pfam00224 161 GVNLPGTDVDLPALSEKDKADLRFGVKNGVDMIFASFVRKASDVLEIREVLGEAGKNIQIIAKIENQEGVNNFDEILEAT 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964  268 DGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAK 347
Cdd:pfam00224 241 DGIMVARGDLGIEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETAK 320

                         330       340
                  ....*....|....*....|....*...
gi 194387964  348 GDYPLEAVRMQHLIAREAEAAMFHRKLF 375
Cdd:pfam00224 321 GNYPVEAVRMMHEICLEAEKALPHRNLF 348
PRK05826 PRK05826
pyruvate kinase; Provisional
 43-494 0e+00

pyruvate kinase; Provisional


Pssm-ID: 235619 [Multi-domain]  Cd Length: 465  Bit Score: 538.58  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964  43 RNTGIICTIGPASRSVETLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTA--------------------TESFASDP 102
Cdd:PRK05826   4 RRTKIVATLGPASDSPENLEKLIEAGVNVVRLNFSHGSHEEHGKRAALVREIaaklgrpvailldlkgpkirVGKFKEGK 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964 103 IikgsgtaevELKKGStlKITLDNAYMEKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKQKGADFLVTEVENGGS 182
Cdd:PRK05826  84 I---------TLKTGD--KFTLDTDQKEEGDKERVGVDYKGLPKDVKPGDILLLDDGKLQLKVVEVDGDEVETEVKNGGP 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964 183 LGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVLGEKG-KNIKIISKIENHEGVRRFD 261
Cdd:PRK05826 153 LSNNKGINIPGGGLSLPALTEKDKADIKFAAEQGVDYIAVSFVRSAEDVEEARRLLREAGcPHAKIIAKIERAEAVDNID 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964 262 EILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIML 341
Cdd:PRK05826 233 EIIEASDGIMVARGDLGVEIPDEEVPGLQKKIIRKAREAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVML 312

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964 342 SGETAKGDYPLEAVRMQHLIAREAEaAMFHRKLFEElvRASSHSTDLMEAMAMGSVEASYK-CLAAALIVLTESGRSAHQ 420
Cdd:PRK05826 313 SGETAAGKYPVEAVEAMARICKGAE-KEFSINLSKH--RLDRQFDRIDEAIAMSAMYAANHlKGVKAIVALTESGRTARL 389

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 194387964 421 VARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLckdpVQEAWAEDVDLRVnfAMNVGKARGFFKKGDVVIVLTG 494
Cdd:PRK05826 390 ISRFRPGAPIFAVTRDEKTQRRLALYRGVYPVL----FDSAADTDDAAEE--ALRLLLEKGLVESGDLVVVTSG 457
 
Name Accession Description Interval E-value
Pyruvate_Kinase cd00288
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ...
 42-510 0e+00

Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.


Pssm-ID: 238178 [Multi-domain]  Cd Length: 480  Bit Score: 789.20  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964  42 ARNTGIICTIGPASRSVETLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATESFASDPII----KG--------SGT 109
Cdd:cd00288    1 LRRTKIVCTIGPATDSVENLKKLIKAGMNVARMNFSHGSHEYHQSRIDNVREAAEKTGGPVAIaldtKGpeirtglfKGG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964 110 AEVELKKGSTLKITLDNAyMEKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKQKGAD-FLVTEVENGGSLGSKKG 188
Cdd:cd00288   81 KDISLKAGDKFLVTTDPA-AKKGTKEKIYVDYKNLTKDVSPGNTILVDDGLLSLKVLSKDDDkTLVCEVLNGGVLGSRKG 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964 189 VNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVLGEKGKNIKIISKIENHEGVRRFDEILEASD 268
Cdd:cd00288  160 VNLPGTDVDLPALSEKDKADLRFGVEQGVDMIFASFVRKASDVLEIREVLGEKGKDIKIIAKIENQEGVNNFDEILEASD 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964 269 GIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKG 348
Cdd:cd00288  240 GIMVARGDLGVEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETAKG 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964 349 DYPLEAVRMQHLIAREAEAAMFHRKLFEELVRASSHSTDLMEAMAMGSVEASYKCLAAALIVLTESGRSAHQVARYRPRA 428
Cdd:cd00288  320 KYPVEAVKAMARICLEAEKALSHRVLFNEMRRLTPRPTSTTEAVAMSAVRAAFELGAKAIVVLTTSGRTARLVSKYRPNA 399

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964 429 PIIAVTRNPQTARQAHLYRGIFPVLCKDPVQEaWAEDVDLRVNFAMNVGKARGFFKKGDVVIVLTGWRPGSGFTNTMRVV 508
Cdd:cd00288  400 PIIAVTRNEQTARQLHLYRGVYPVLFEEPKPG-WQEDTDARLKAAVNVAKEKGLLKKGDLVVVVQGWPVGSGSTNTMRIL 478


                 ..
gi 194387964 509 PV 510
Cdd:cd00288  479 TV 480
pyruv_kin TIGR01064
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of ...
 43-507 0e+00

pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of fructose-1,6-bisphosphate or similar phosphorylated sugars. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 273424 [Multi-domain]  Cd Length: 472  Bit Score: 716.37  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964   43 RNTGIICTIGPASRSVETLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATESF------ASD---PIIKGSGTA--E 111
Cdd:TIGR01064   1 RRTKIVCTIGPATNSPEMLKKLLDAGMNVARLNFSHGSHEEHGKRIENVREAAEKLgrpvaiLLDtkgPEIRTGEIKggE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964  112 VELKKGSTLKITLDNAYMEkCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKQKGADFLVTEVENGGSLGSKKGVNL 191
Cdd:TIGR01064  81 VKLKKGDKVIITTDDIKGE-GDEEKVYVDYKGLTKDVVEGDKILVDDGKISLVVVSVEGDKVICEVLNGGTLKSKKGVNL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964  192 PGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVLGEKG-KNIKIISKIENHEGVRRFDEILEASDGI 270
Cdd:TIGR01064 160 PGADVDLPALSEKDKKDLKFGVEQGVDMVAASFVRTAEDVLEVREVLGEKGaKDVKIIAKIENQEGVDNIDEIAEASDGI 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964  271 MVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDY 350
Cdd:TIGR01064 240 MVARGDLGVEIPAEEVPIAQKKMIRKCNRAGKPVITATQMLDSMIKNPRPTRAEVSDVANAVLDGTDAVMLSGETAKGKY 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964  351 PLEAVRMQHLIAREAEAAMFHRKLFEELVRASSHSTDLMEAMAMGSVEASYKCLAAALIVLTESGRSAHQVARYRPRAPI 430
Cdd:TIGR01064 320 PVEAVQMMAKIAKEAEKALAYLTNFNDRKNSDPKPSTITEAIALSAVEAAEKLDAKAIVVLTESGRTARLLSKYRPNAPI 399

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 194387964  431 IAVTRNPQTARQAHLYRGIFPVLCKDpvqeaWAEDVDLRVNFAMNVGKARGFFKKGDVVIVLTG-WRPGSGFTNTMRV 507
Cdd:TIGR01064 400 IAVTPNERVARQLALYWGVFPFLVDE-----EPSDTDARVNKALELLKEKGIVKKGDLVVVIQGgPIGGEGGTNTIRV 472
PykF COG0469
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the ...
 43-510 0e+00

Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 440237 [Multi-domain]  Cd Length: 471  Bit Score: 637.46  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964  43 RNTGIICTIGPASRSVETLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTA--------------------TESFASDP 102
Cdd:COG0469    3 RRTKIVATLGPASDSPEVLRKLIEAGMDVARLNFSHGDHEEHRERIELIREAakelgrpvailldlqgpkirTGKFKEGP 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964 103 IikgsgtaevELKKGSTLKITLDNaymEKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKQKGADFLVTEVENGGS 182
Cdd:COG0469   83 V---------ELKKGDTFTLTTDD---VEGDAERVSVTYPELPEDVKPGDRILLDDGKIELRVEEVEGDEVVCEVVNGGV 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964 183 LGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVLGEKGKNIKIISKIENHEGVRRFDE 262
Cdd:COG0469  151 LSSRKGVNLPGVGLSLPALTEKDREDLKFALELGVDFIALSFVRSAEDVLEARELLEEAGGRAPIIAKIEKPEAVENLDE 230

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964 263 ILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLS 342
Cdd:COG0469  231 IIEASDGIMVARGDLGVEIPLEEVPLIQKRIIRKARRAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLS 310

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964 343 GETAKGDYPLEAVRMQHLIAREAEAAMFHRKLFEELVRASSHSTDlmEAMAMGSVEASYKCLAAALIVLTESGRSAHQVA 422
Cdd:COG0469  311 GETAVGKYPVEAVETMARIAEEAEKSLDYRRILDRLRDEPERTIT--DAIARAAVELAEDLGAKAIVAFTESGSTARRIS 388

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964 423 RYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDpvqeawAEDVDLRVNFAMNVGKARGFFKKGDVVIVLTGWRPG-SGF 501
Cdd:COG0469  389 RYRPKVPILALTPNERTARRLALVWGVYPVLVDD------VESTDEMIEEAVEALLEEGLVKPGDLVVITAGVPVGvPGT 462


                 ....*....
gi 194387964 502 TNTMRVVPV 510
Cdd:COG0469  463 TNTLKVHRV 471
PK pfam00224
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain ...
 42-375 0e+00

Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel. The active site is found in a cleft between the two domains.


Pssm-ID: 395168 [Multi-domain]  Cd Length: 348  Bit Score: 588.95  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964   42 ARNTGIICTIGPASRSVETLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATESFASDPII----KG---------SG 108
Cdd:pfam00224   1 LRRTKIVCTIGPASNSVENLEKLIEAGANVARMNFSHGSHEYHQSRIDNVREAEEKTGGTVAIaldtKGpeirtgntkDG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964  109 TAEVELKKGSTLKITLDNAYMEKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKQKGADF-LVTEVENGGSLGSKK 187
Cdd:pfam00224  81 KKDIELKAGDEMIVSTDAKYKGACDDEMIYVDYKNIVKDVSVGGTILVDDGLLSLKVLSKDDDKtLVVEVLNGGVIGSRK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964  188 GVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVLGEKGKNIKIISKIENHEGVRRFDEILEAS 267
Cdd:pfam00224 161 GVNLPGTDVDLPALSEKDKADLRFGVKNGVDMIFASFVRKASDVLEIREVLGEAGKNIQIIAKIENQEGVNNFDEILEAT 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964  268 DGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAK 347
Cdd:pfam00224 241 DGIMVARGDLGIEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETAK 320

                         330       340
                  ....*....|....*....|....*...
gi 194387964  348 GDYPLEAVRMQHLIAREAEAAMFHRKLF 375
Cdd:pfam00224 321 GNYPVEAVRMMHEICLEAEKALPHRNLF 348
PRK05826 PRK05826
pyruvate kinase; Provisional
 43-494 0e+00

pyruvate kinase; Provisional


Pssm-ID: 235619 [Multi-domain]  Cd Length: 465  Bit Score: 538.58  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964  43 RNTGIICTIGPASRSVETLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTA--------------------TESFASDP 102
Cdd:PRK05826   4 RRTKIVATLGPASDSPENLEKLIEAGVNVVRLNFSHGSHEEHGKRAALVREIaaklgrpvailldlkgpkirVGKFKEGK 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964 103 IikgsgtaevELKKGStlKITLDNAYMEKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKQKGADFLVTEVENGGS 182
Cdd:PRK05826  84 I---------TLKTGD--KFTLDTDQKEEGDKERVGVDYKGLPKDVKPGDILLLDDGKLQLKVVEVDGDEVETEVKNGGP 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964 183 LGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVLGEKG-KNIKIISKIENHEGVRRFD 261
Cdd:PRK05826 153 LSNNKGINIPGGGLSLPALTEKDKADIKFAAEQGVDYIAVSFVRSAEDVEEARRLLREAGcPHAKIIAKIERAEAVDNID 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964 262 EILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIML 341
Cdd:PRK05826 233 EIIEASDGIMVARGDLGVEIPDEEVPGLQKKIIRKAREAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVML 312

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964 342 SGETAKGDYPLEAVRMQHLIAREAEaAMFHRKLFEElvRASSHSTDLMEAMAMGSVEASYK-CLAAALIVLTESGRSAHQ 420
Cdd:PRK05826 313 SGETAAGKYPVEAVEAMARICKGAE-KEFSINLSKH--RLDRQFDRIDEAIAMSAMYAANHlKGVKAIVALTESGRTARL 389

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 194387964 421 VARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLckdpVQEAWAEDVDLRVnfAMNVGKARGFFKKGDVVIVLTG 494
Cdd:PRK05826 390 ISRFRPGAPIFAVTRDEKTQRRLALYRGVYPVL----FDSAADTDDAAEE--ALRLLLEKGLVESGDLVVVTSG 457
PRK09206 PRK09206
pyruvate kinase PykF;
43-507 1.73e-179

pyruvate kinase PykF;


Pssm-ID: 181699 [Multi-domain]  Cd Length: 470  Bit Score: 512.29  E-value: 1.73e-179
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964  43 RNTGIICTIGPASRSVETLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATESFASDPII----KG--------SGTA 110
Cdd:PRK09206   2 KKTKIVCTIGPKTESEEMLTKLLDAGMNVMRLNFSHGDYAEHGQRIKNLRNVMSKTGKKAAIlldtKGpeirtmklEGGN 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964 111 EVELKKGSTLKITLDNAYMEkcDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKQKGADFLVTEVENGGSLGSKKGVN 190
Cdd:PRK09206  82 DVSLKAGQTFTFTTDKSVVG--NKERVAVTYEGFTADLSVGNTVLVDDGLIGMEVTAITGNEVICKVLNNGDLGENKGVN 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964 191 LPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVLGE-KGKNIKIISKIENHEGVRRFDEILEASDG 269
Cdd:PRK09206 160 LPGVSIALPALAEKDKQDLIFGCEQGVDFVAASFIRKRSDVLEIREHLKAhGGENIQIISKIENQEGLNNFDEILEASDG 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964 270 IMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGD 349
Cdd:PRK09206 240 IMVARGDLGVEIPVEEVIFAQKMMIEKCNRARKVVITATQMLDSMIKNPRPTRAEAGDVANAILDGTDAVMLSGESAKGK 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964 350 YPLEAVRMQHLIAREAEAAMfHRKLFEELVrasSHSTDLMEAMAMGSVEASYKcLAAALIVL-TESGRSAHQVARYRPRA 428
Cdd:PRK09206 320 YPLEAVSIMATICERTDRVM-NSRLESNND---NRKLRITEAVCRGAVETAEK-LDAPLIVVaTQGGKSARSVRKYFPDA 394

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 194387964 429 PIIAVTRNPQTARQAHLYRGIFPVLCKDPvqeAWAEDVDLRvnfAMNVGKARGFFKKGDVVIVLTGWRPGSGFTNTMRV 507
Cdd:PRK09206 395 TILALTTNEKTARQLVLSKGVVPQLVKEI---ASTDDFYRL---GKELALQSGLAQKGDVVVMVSGALVPSGTTNTASV 467
PLN02461 PLN02461
Probable pyruvate kinase
 45-492 2.86e-178

Probable pyruvate kinase


Pssm-ID: 215255 [Multi-domain]  Cd Length: 511  Bit Score: 510.68  E-value: 2.86e-178
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964  45 TGIICTIGPASRSVETLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATESFASD---------PIIKgSGTAE---- 111
Cdd:PLN02461  23 TKIVCTLGPASRSVPMLEKLLRAGMNVARFNFSHGSHEYHQETLDNLRQAMANTGILcavmldtkgPEIR-TGFLKdgkp 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964 112 VELKKGSTLKITLDnaYMEKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQV----KQKGadfLVT-EVENGGSLGSK 186
Cdd:PLN02461 102 VQLKQGQEITITTD--YSIKGDENMIAMSYKKLAVDVKPGSVILCADGTITLTVlscdVEAG---TVRcRCENSAMLGER 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964 187 KGVNLPGAAVDLPAVSEKDIQD-LKFGVEQDVDMVFASFIRKASDVHEVRKVLGEKGKNIKIISKIENHEGVRRFDEILE 265
Cdd:PLN02461 177 KNVNLPGVVVDLPTLTEKDKEDiLQWGVPNKIDFIALSFVRKGSDLVEVRKVLGEHAKSILLISKVENQEGLDNFDDILA 256

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964 266 ASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGET 345
Cdd:PLN02461 257 ESDAFMVARGDLGMEIPIEKIFLAQKMMIYKCNLAGKPVVTATQMLESMIKSPRPTRAEATDVANAVLDGTDCVMLSGET 336

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964 346 AKGDYPLEAVRMQHLIAREAEAAMFHRKLFEELVRASSHSTDLMEAMAMGSVEASYKCLAAALIVLTESGRSAHQVARYR 425
Cdd:PLN02461 337 AAGAYPELAVKTMARICREAEASLDYGALFKEIMRSAPLPMSPLESLASSAVRTANKVKASLIVVLTRGGTTARLVAKYR 416

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964 426 PRAPIIAV-------------TRNPQTARQAHLYRGIFPVLCKDPVQEAWAEDVDLRVNFAMNVGKARGFFKKGDVVIVL 492
Cdd:PLN02461 417 PAVPILSVvvpeittdsfdwsCSDEAPARHSLIYRGLIPVLAEGSAKATDSESTEEILEAAIEHAKKKGLCKPGDSVVAL 496
PRK06354 PRK06354
pyruvate kinase; Provisional
 30-507 1.80e-168

pyruvate kinase; Provisional


Pssm-ID: 235784 [Multi-domain]  Cd Length: 590  Bit Score: 488.67  E-value: 1.80e-168
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964  30 MCRLDidsppiTARNTGIICTIGPASRSVETLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATESFASDPII----K 105
Cdd:PRK06354   1 MSLRD------LMRRTKIVATIGPASESPEKLRQLIEAGATTARLNFSHGDHEEHGARIKNIREASKKLGKTVGIlqdlQ 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964 106 G----SGTAE---VELKKGSTLKITLDNAymeKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKQ--KGADFLVTE 176
Cdd:PRK06354  75 GpkirLGRFEdgpIELKTGDEFILTSREV---LGTQEKFSVTYDGLADEVPVGSRILLDDGLIELEVEEvdKADGELHCK 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964 177 VENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVLGEK-GKNIKIISKIENHE 255
Cdd:PRK06354 152 VLVGGVLSNKKGVNFPGVSLSLPAITEKDREDLIFGLEQGVDWIALSFVRNPSDVLEIRELIEEHnGKHIPIIAKIEKQE 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964 256 GVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDG 335
Cdd:PRK06354 232 AIDNIDAILELCDGLMVARGDLGVEIPAEEVPLLQKRLIKKANRLGKPVITATQMLDSMQRNPRPTRAEASDVANAILDG 311

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964 336 ADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAMFHRKLFEELvraSSHSTDLMEAMAMGSVEASYKCLAAALIVLTESG 415
Cdd:PRK06354 312 TDAVMLSNETAAGDYPVEAVQTMATIAVRIEKDLPYRDILSKR---PEFTTTITNAISQAVSHIALQLDAAAIVTLTKSG 388

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964 416 RSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDpvqeawAEDVDLRVNFAMNVGKARGFFKKGDVVIVLTGW 495
Cdd:PRK06354 389 ATARNVSKYRPKTPILAVTPNESVARRLQLVWGVTPLLVLD------APSTDETFDAAINVAQESGLLKQGDLVVITAGT 462

                        490
                 ....*....|...
gi 194387964 496 RPG-SGFTNTMRV 507
Cdd:PRK06354 463 LVGeSGSTDLMKV 475
PTZ00066 PTZ00066
pyruvate kinase; Provisional
 8-511 6.20e-162

pyruvate kinase; Provisional


Pssm-ID: 173361 [Multi-domain]  Cd Length: 513  Bit Score: 469.24  E-value: 6.20e-162
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964   8 AGTAFIQTQQLHAAmADTFLEHMCRlDIDSPPITARNTGIICTIGPASRSVETLKEMIKSGMNVARLNFSHGTHEYHAET 87
Cdd:PTZ00066   5 ASTSSVMGCSLGKA-TNISLDKILE-PISDNDLRQKKTHIVCTMGPACKNVETLVKLIDAGMNICRFNFSHGDHESHKKT 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964  88 IKNVRTATESFASDPI-----IKG--------SGTAEVELKKGSTLKITLDnaYMEKCDENILWLDYKNICKVVEVGSKI 154
Cdd:PTZ00066  83 LNNVREAAKARPNANLgilldTKGpeirtgflKNHKPITLKEGQTLKITTD--YTFLGDETCISCSYKKLPQSVKVGNII 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964 155 YVDDGLISLQVKQKGADFLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEKDIQD-LKFGVEQDVDMVFASFIRKASDVHE 233
Cdd:PTZ00066 161 LIADGSLSCKVLEVHDDYIITKVLNNATIGERKNMNLPGVKVELPVIGEKDKNDiLNFAIPMGCDFIALSFVQSADDVRL 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964 234 VRKVLGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLES 313
Cdd:PTZ00066 241 CRQLLGERGRHIKIIPKIENIEGLINFDEILAESDGIMVARGDLGMEIPPEKVFLAQKMMISKCNVAGKPVITATQMLES 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964 314 MIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAMFHRKLFEELVRASSHSTDLMEAMA 393
Cdd:PTZ00066 321 MIKNPRPTRAESTDVANAVLDGTDCVMLSGETANGKFPVEAVNIMAKICFEAETCIDYRVLYHAIHLAVPTPVSVQEAVA 400

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964 394 MGSVEASYKCLAAALIVLTESGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVlCKDPVQeawaeDVDLRVNFA 473
Cdd:PTZ00066 401 RSAVETAEDINAKLIIALTETGNTARLISKYRPSCTILALSASPSVVKSLSVARGVTTY-VVNSFQ-----GTDVVIRNA 474

                        490       500       510
                 ....*....|....*....|....*....|....*....
gi 194387964 474 MNVGKARGFFKKGDVVIVLTGWRPG-SGFTNTMRVVPVP 511
Cdd:PTZ00066 475 IALAKERGLVESGDSAIAVHGVKEEvAGSSNLMKVVKIP 513
PTZ00300 PTZ00300
pyruvate kinase; Provisional
 69-510 3.31e-156

pyruvate kinase; Provisional


Pssm-ID: 140321 [Multi-domain]  Cd Length: 454  Bit Score: 452.58  E-value: 3.31e-156
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964  69 MNVARLNFSHGTHEYHAETIKNVRTATESFASDPII----KG----SGT---AEVELKKGSTLKITLDNAYMEKCDENIL 137
Cdd:PTZ00300   1 MSVARMNFSHGSHEYHQTTINNVRQAAAELGVNIAIaldtKGpeirTGLfvgGEAVMERGATCYVTTDPAFADKGTKDKF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964 138 WLDYKNICKVVEVGSKIYVDDGLISLQVKQKGADF-LVTEVENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQD 216
Cdd:PTZ00300  81 YIDYQNLSKVVRPGGYIYIDDGILILHVQSHEDEQtLKCTVTNAHTISDRRGVNLPGCDVDLPAVSAKDCADLQFGVEQG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964 217 VDMVFASFIRKASDVHEVRKVLGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGR 296
Cdd:PTZ00300 161 VDMIFASFIRSAEQVGEVRKALGAKGGDIMIICKIENHQGVQNIDSIIEESDGIMVARGDLGVEIPAEKVVVAQKILISK 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964 297 CNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAMFHRKLFE 376
Cdd:PTZ00300 241 CNVAGKPVICATQMLESMTYNPRPTRAEVSDVANAVFNGADCVMLSGETAKGKYPNEVVQYMARICLEAQSAVNEYVFFN 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964 377 ELVRASSHSTDLMEAMAMGSVEASYKCLAAALIVLTESGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCkD 456
Cdd:PTZ00300 321 SIKKLQPIPMSAEEAVCSSAVNSVYETKAKALVVLSNTGRSARLVAKYRPNCPIVCVTTRLQTCRQLNITQGVESVFF-D 399

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....
gi 194387964 457 PVQEAWAEDVDLRVNFAMNVGKARGFFKKGDVVIVLTGWRPGSGFTNTMRVVPV 510
Cdd:PTZ00300 400 AERLGHDEGKEQRVAMGVGFAKSKGYVQSGDLMVVVHADHKVKGYANQTRIILV 453
PRK06247 PRK06247
pyruvate kinase; Provisional
 42-507 4.10e-147

pyruvate kinase; Provisional


Pssm-ID: 180487 [Multi-domain]  Cd Length: 476  Bit Score: 430.12  E-value: 4.10e-147
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964  42 ARNTGIICTIGPASRSVETLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATES--------------------FASD 101
Cdd:PRK06247   4 NRRVKILATLGPASSSEDMIRKLVEAGADVFRLNFSHGDHDDHRELYKRIREVEDEtgrpigiladlqgpklrlgrFADG 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964 102 PiikgsgtaeVELKKGSTLKITLDNAymeKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKQKGADFLVTEVENGG 181
Cdd:PRK06247  84 K---------VQLANGQTFRLDVDDA---PGDHDRVSLPHPEIAAALKPGDRLLVDDGKVRLVVEACDGDDVVCRVVEGG 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964 182 SLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVLGEKgknIKIISKIENHEGVRRFD 261
Cdd:PRK06247 152 PVSDRKGVSLPGTVLSVSALTEKDRADLEFALELGVDWVALSFVQRPEDVEEVRKIIGGR---VPVMAKIEKPQAIDRLE 228

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964 262 EILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIML 341
Cdd:PRK06247 229 AIVEASDAIMVARGDLGVEVPLEQVPLIQKRIIRAARRAGKPVVVATQMLESMIENPVPTRAEVSDVATAVLDGADAVML 308

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964 342 SGETAKGDYPLEAVRMQHLIAREAEAamfhrklfEELVRASSH-STDLMEAMAMGSVEASYKCLA-----AALIVLTESG 415
Cdd:PRK06247 309 SAETASGKYPVEAVRTMARIIRQVER--------DPTYPPLIHaQRPQPEATKRDAISYAARDIAerldlAALVAYTSSG 380

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964 416 RSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDpvqeawAEDVDLRVNFAMNVGKARGFFKKGDVVIVLTGW 495
Cdd:PRK06247 381 DTALRAARERPPLPILALTPNPETARRLALTWGVHCVVVDD------ARDTDDMVRRADRIALAEGFYKRGDRVVIVAGV 454

                        490
                 ....*....|...
gi 194387964 496 RPG-SGFTNTMRV 507
Cdd:PRK06247 455 PPGtPGSTNMLRI 467
PLN02765 PLN02765
pyruvate kinase
 45-491 4.52e-114

pyruvate kinase


Pssm-ID: 215409 [Multi-domain]  Cd Length: 526  Bit Score: 347.43  E-value: 4.52e-114
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964  45 TGIICTIGPASRSVETLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATES-----------FASDPIIKGSGTAEVE 113
Cdd:PLN02765  30 TKIVGTLGPKSRSVEVIEACLKAGMSVARFDFSWGDAEYHQETLENLKIAVKNtkklcavmldtVGPELQVINKTEKPIS 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964 114 LKKGSTLKITLDNayMEKCDENILWLDYKNICKVVEVGSKIYVDDGLIS--------LQVKQKGADFLVTEVENGGSL-G 184
Cdd:PLN02765 110 LKAGNTVTLTPDQ--SKEASSEVLPINFPGLAKAVKPGDTIFVGQYLFTgsettsvwLEVDEVKGDDVVCTVKNSATLaG 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964 185 SKKGVNLPGAAVDLPAVSEKDIQDLK-FGVEQDVDMVFASFIRKASDVHEVRKVLGEKG-KNIKIISKIENHEGVRRFDE 262
Cdd:PLN02765 188 SLFTLHVSQVRIDLPTLSEKDKEVIStWGVPNKIDFLSLSYTRHAEDVREAREFLSSLGlSQTQIFAKIENVEGLTHFDE 267

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964 263 ILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVIcATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLS 342
Cdd:PLN02765 268 ILQEADGIILSRGNLGIDLPPEKVFLFQKAALYKCNMAGKPAV-VTRVVDSMTDNLRPTRAEATDVANAVLDGADAILLG 346

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964 343 GETAKGDYPLEAVRMQHLIAREAEAAMFHRKLFEELVRASSHSTDLMEAMAMGSVEASYKCLAAALIVLTESGRSAHQVA 422
Cdd:PLN02765 347 AETLRGLYPVETISTVGRICAEAEKVFNQDLYFKKTVKYVGEPMSHLESIASSAVRAAIKVKASVIIVFTSSGRAARLIA 426

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964 423 RYRPRAPIIAV-----TRNP--------QTARQAHLYRGIFPVLCkDPVQEA----WAEDVDLRVnfAMNVGKARGFFKK 485
Cdd:PLN02765 427 KYRPTMPVLSVviprlKTNQlkwsftgaFQARQCLIVRGLFPMLA-DPRHSAestsATNESVLKV--ALDHGKAAGVIKS 503


                 ....*.
gi 194387964 486 GDVVIV 491
Cdd:PLN02765 504 HDRVVV 509
PLN02623 PLN02623
pyruvate kinase
 37-497 3.03e-104

pyruvate kinase


Pssm-ID: 215334 [Multi-domain]  Cd Length: 581  Bit Score: 323.80  E-value: 3.03e-104
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964  37 SPPITARNTGIICTIGPASRSVETLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATESFASDPI-----IKG----S 107
Cdd:PLN02623 104 SKPSVRRKTKIVCTIGPSTNTREMIWKLAEAGMNVARLNMSHGDHASHQKVIDLVKEYNAQSKDNVIaimldTKGpevrS 183

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964 108 GTAE--VELKKGSTLKITLDNAY-MEKCdeniLWLDYKNICKVVEVGSKIYVDDGLISLQVKQKGADFLVTEVENGGSLG 184
Cdd:PLN02623 184 GDLPqpIMLEEGQEFTFTIKRGVsTEDC----VSVNYDDFVNDVEVGDMLLVDGGMMSLAVKSKTSDSVKCEVVDGGELK 259

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964 185 SKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVLGEKGKNIKIISKIENHEGVRRFDEIL 264
Cdd:PLN02623 260 SRRHLNVRGKSATLPSITEKDWEDIKFGVENKVDFYAVSFVKDAQVVHELKDYLKSCNADIHVIVKIESADSIPNLHSII 339

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964 265 EASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGE 344
Cdd:PLN02623 340 TASDGAMVARGDLGAELPIEEVPLLQEEIIRRCRSMGKPVIVATNMLESMIVHPTPTRAEVSDIAIAVREGADAVMLSGE 419

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964 345 TAKGDYPLEAVRMQHLIAREAEAAMFHRKLFEELVRASSHSTDLM---EAMAMGSVeasykcLAAALIVLTESGRSAHQV 421
Cdd:PLN02623 420 TAHGKFPLKAVKVMHTVALRTEATLPEGTTPPNLGQAFKNHMSEMfafHATMMANT------LGTSIIVFTRTGFMAILL 493

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 194387964 422 ARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKdpvqeaWAEDVDLRVNFAMNVGKARGFFKKGD-VVIVLTGWRP 497
Cdd:PLN02623 494 SHYRPSGTIFAFTNEKRIQQRLALYQGVCPIYMQ------FSDDAEETFARALSLLLNKGMVKEGEeVALVQSGRQP 564
PRK06739 PRK06739
pyruvate kinase; Validated
 48-366 2.07e-96

pyruvate kinase; Validated


Pssm-ID: 180676 [Multi-domain]  Cd Length: 352  Bit Score: 296.09  E-value: 2.07e-96
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964  48 ICTIGPASRSVETLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATES--FASD--------PIIKGSgtaEVELKKG 117
Cdd:PRK06739   6 ICTIGPASNNKETLAQLINNGMKIVRLNLSHGTHESHKDIIRLVKSLDDSikILGDvqgpkirlGEIKGE---QITLQAG 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964 118 STLKITLDNAYMEKCDENIlwlDYKNICKVVEVGSKIYVDDGLISLQVKQKGADFLVTEVENGGSLGSKKGVNLPGAAVD 197
Cdd:PRK06739  83 DSFILHTQPVTGSSTEASV---DYEGIANDVKVGSRILMNDGEVELIVEKVSTDKIETKVKTGGNISSHKGVNLPGAIVR 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964 198 LPAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVLGEKGKNI-KIISKIENHEGVRRFDEILEASDGIMVARGD 276
Cdd:PRK06739 160 LPAITEKDKKDIQFLLEEDVDFIACSFVRKPSHIKEIRDFIQQYKETSpNLIAKIETMEAIENFQDICKEADGIMIARGD 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964 277 LGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVR 356
Cdd:PRK06739 240 LGVELPYQFIPLLQKMMIQECNRTNTYVITATQMLQSMVDHSIPTRAEVTDVFQAVLDGTNAVMLSAESASGEHPIESVS 319

                        330
                 ....*....|
gi 194387964 357 MQHLIAREAE 366
Cdd:PRK06739 320 TLRLVSEFAE 329
PLN02762 PLN02762
pyruvate kinase complex alpha subunit
 42-511 1.99e-83

pyruvate kinase complex alpha subunit


Pssm-ID: 215407 [Multi-domain]  Cd Length: 509  Bit Score: 267.38  E-value: 1.99e-83
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964  42 ARNTGIICTIGPASRSVETLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATESfasdpiiKGSGTAEVELKKGSTLK 121
Cdd:PLN02762  24 TRRTKLVCTIGPACCGFEQLEALAMGGMNVARLNMCHGTREWHRDVIRRVRRLNEE-------KGFAVAVMMDTEGSEIH 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964 122 IT-LDNAYMEKCDENILWL-----------------DYKNICKVVEVGSKIYVDDGLISLQVKQK-GADFLVTEVENG-- 180
Cdd:PLN02762  97 MGdLGGASSAKAEDGEEWTftvrkfdgsrpeftiqvNYDGFAEDVKVGDELVVDGGMVRFEVIEKiGPDVKCKCTDPGll 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964 181 -----------GSLGSKKGVNLPgaavdlpAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVLGEKGKN--IKI 247
Cdd:PLN02762 177 lpranltfwrdGSLVRERNAMLP-------TISSKDWLDIDFGISEGVDFIAVSFVKSAEVIKHLKSYIAARSRDsdIGV 249

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964 248 ISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSD 327
Cdd:PLN02762 250 IAKIESLDSLKNLEEIIRASDGAMVARGDLGAQIPLEQVPSVQEKIVRLCRQLNKPVIVASQLLESMIEYPTPTRAEVAD 329

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964 328 VANAVLDGADCIMLSGETAKGDYPLEAV--------RMQHLIAREAEAAMFHRKlfeELvrASSHSTDLMEAMAMGSVEA 399
Cdd:PLN02762 330 VSEAVRQRADALMLSGESAMGLYPEKALsvlrsvslRMELWSREEKRHEALELP---QL--SSSLSDRISEEICNSAAKM 404

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964 400 SYKCLAAALIVLTESGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCkdpvqeAWAEDVDLRVNFAMNVGKA 479
Cdd:PLN02762 405 ANNLGVDAIFVYTKHGHMASLLSRNRPDCPIFAFTDTTSVRRRLNLQWGLIPFRL------DFSDDMESNLNKTFSLLKA 478

                        490       500       510
                 ....*....|....*....|....*....|..
gi 194387964 480 RGFFKKGDVVIVLTGWRPgSGFTNTMRVVPVP 511
Cdd:PLN02762 479 RGMIKSGDLVIAVSDLTP-SSMLQSIQVRNVP 509
PRK08187 PRK08187
pyruvate kinase; Validated
 38-358 2.47e-44

pyruvate kinase; Validated


Pssm-ID: 236178  Cd Length: 493  Bit Score: 163.26  E-value: 2.47e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964  38 PPITARNTGIICTI-GPASRSVETLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATES---------------FASD 101
Cdd:PRK08187 128 PRPAARRTRIMVTLpSEAADDPDFVLRLAERGMDCARINCAHDDPAAWQAMIGHLRQAERAtgrrckilmdlagpkIRTG 207

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964 102 PIIKGSGtaEVELKKGSTLKITLDNAyMEKCDENILWLDykniCKV------VEVGSKIYVDDGLISLQVKQKGADFLVT 175
Cdd:PRK08187 208 AVAGPLG--KTRLYTGDRLALVAQGP-PRRIDEEHFQVT----CTLpeilarLAVGARVWIDDGKLGARVERVGPGGALL 280

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964 176 EV----ENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQdVDMVFASFIRKASDVHEVRKVLGEKGKN----IKI 247
Cdd:PRK08187 281 EVtharPKGLKLKPEKGLNFPDTALDLPALTEKDRADLDFVARH-ADLVGYSFVQSPGDVEALQAALAARRPDdwrkLGL 359

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964 248 ISKIENHEGVRRFDEILEASDG-----IMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTR 322
Cdd:PRK08187 360 VLKIETPRAVANLPELIVQAAGrqpfgVMIARGDLAVEIGFERLAEMQEEILWLCEAAHVPVIWATQVLEGLVKKGLPSR 439

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....
gi 194387964 323 AEGSDVANAvlDGADCIMLSgetaKGDYPLEAV--------RMQ 358
Cdd:PRK08187 440 AEMTDAAMA--ARAECVMLN----KGPYLVEAVtflddllaRMD 477
PykA2 COG3848
Phosphohistidine swiveling domain of PEP-utilizing enzymes [Signal transduction mechanisms];
296-510 1.72e-42

Phosphohistidine swiveling domain of PEP-utilizing enzymes [Signal transduction mechanisms];


Pssm-ID: 443058  Cd Length: 321  Bit Score: 153.90  E-value: 1.72e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964 296 RCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAMFHRKLF 375
Cdd:COG3848    1 KCNAAGKPVITATQMLDSMMRNPRPTRAEAADVANAIFDGTDAIMLSGETAAGKYPVEAVVTMVRIAERAEEDLEYREQR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964 376 EElvRASSHSTDLMEAMAMGSVEASYKCLAAALIVLTESGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCK 455
Cdd:COG3848   81 VP--RAKESSTTITDAISHAVATTAADLGAAAIITATESGATARMVSKYRPKAPIIAVTPSERVARQLSLVWGVYPLLVE 158

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 194387964 456 DpvqeawAEDVDLRVNFAMNVGKARGFFKKGDVVI----VLTGwrpGSGFTNTMRVVPV 510
Cdd:COG3848  159 E------SASTDEMFAVAVALALEAGLVKDGDLVVitagVPVG---VSGTTNLLKVHVV 208
PRK14725 PRK14725
pyruvate kinase; Provisional
 148-378 8.02e-41

pyruvate kinase; Provisional


Pssm-ID: 237804  Cd Length: 608  Bit Score: 155.11  E-value: 8.02e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964 148 VEVGSKIYVDDGLISLQVKQKGADFLVTEVENGGSLGSK----KGVNLPGAAVDLPAVSEKDIQDLKFGVEQdVDMVFAS 223
Cdd:PRK14725 373 ARVGERVWFDDGKIGAVVVKVEADEVELRITHARPGGSKlkagKGINLPDSHLPLPALTDKDLEDLAFVAKH-ADIVALS 451

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964 224 FIRKASDVHEVRKVLGE-KGKNIKIISKIENHEGVRRFDEI-LEA----SDGIMVARGDLGIEIPAEKVFLAQKMMIGRC 297
Cdd:PRK14725 452 FVRSPEDVRLLLDALEKlGADDLGVVLKIETRRAFENLPRIlLEAmrhpRFGVMIARGDLAVEVGFERLAEVQEEILWLC 531

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964 298 NRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLdgADCIMLSgetaKGDYPLEAVRMQHLIAREAEAamFHRKLFEE 377
Cdd:PRK14725 532 EAAHVPVIWATQVLESLAKKGLPSRAEITDAAMALR--AECVMLN----KGPHIVEAVRVLDDILRRMEE--HQRKKRSL 603


                 .
gi 194387964 378 L 378
Cdd:PRK14725 604 L 604
PK_C pfam02887
Pyruvate kinase, alpha/beta domain; As well as being found in pyruvate kinase this family is ...
 390-508 1.14e-40

Pyruvate kinase, alpha/beta domain; As well as being found in pyruvate kinase this family is found as an isolated domain in some bacterial proteins.


Pssm-ID: 460738 [Multi-domain]  Cd Length: 114  Bit Score: 142.23  E-value: 1.14e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387964  390 EAMAMGSVEASYKCLAAALIVLTESGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDpvqeawAEDVDLR 469
Cdd:pfam02887   1 EAIAHAAVEAAEELGAKAIVVLTESGYTARLISRYRPGVPIIAVTPNELTARQLALYWGVYPVLFDE------AETTDEM 74

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 194387964  470 VNFAMNVGKARGFFKKGDVVIVLTGWRPG-SGFTNTMRVV 508
Cdd:pfam02887  75 LRRAVKVAKEAGLVKKGDLVVITAGVPFGvSGTTNTLKVI 114
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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