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Conserved domains on  [gi|222422842|dbj|BAH19408|]
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AT5G66055 [Arabidopsis thaliana]

Protein Classification

ankyrin repeat domain-containing protein( domain architecture ID 11429852)

ankyrin repeat domain-containing protein; ANK proteins mediate specific protein-protein interactions without necessarily recognizing specific primary sequences which allows for one ankyrin repeat domain to recognize and bind to a variety of intracellular substrates and may be involved in a wide array of functions

Gene Ontology:  GO:0005515
PubMed:  17176038
SCOP:  4000366

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
236-417 3.47e-37

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 137.39  E-value: 3.47e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222422842 236 KLLSKEEKFMLNSRNPDLAVATSKKWLPLHTLAACGEFYLVDSLLKHNLDINATDVGGLTVLHRAIIGKKQAITNYLLRE 315
Cdd:COG0666   63 LAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEA 142

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222422842 316 SANPFVLDDEGATLMHYAVQTASAPTIKLLLLYNADINAQDRDGWTPLHVAVQARRSDIVKLLLIKGADIEVKNKDGLTP 395
Cdd:COG0666  143 GADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTA 222

                        170       180
                 ....*....|....*....|..
gi 222422842 396 LGLCLYLGREirtyEVMKLLKE 417
Cdd:COG0666  223 LDLAAENGNL----EIVKLLLE 240
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
236-417 3.47e-37

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 137.39  E-value: 3.47e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222422842 236 KLLSKEEKFMLNSRNPDLAVATSKKWLPLHTLAACGEFYLVDSLLKHNLDINATDVGGLTVLHRAIIGKKQAITNYLLRE 315
Cdd:COG0666   63 LAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEA 142

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222422842 316 SANPFVLDDEGATLMHYAVQTASAPTIKLLLLYNADINAQDRDGWTPLHVAVQARRSDIVKLLLIKGADIEVKNKDGLTP 395
Cdd:COG0666  143 GADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTA 222

                        170       180
                 ....*....|....*....|..
gi 222422842 396 LGLCLYLGREirtyEVMKLLKE 417
Cdd:COG0666  223 LDLAAENGNL----EIVKLLLE 240
Ank_2 pfam12796
Ankyrin repeats (3 copies);
297-389 1.86e-20

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 85.55  E-value: 1.86e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222422842  297 LHRAIIGKKQAITNYLLRESANPFVLDDEGATLMHYAVQTASAPTIKLLLLYnADINAQDrDGWTPLHVAVQARRSDIVK 376
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVK 78

                          90
                  ....*....|...
gi 222422842  377 LLLIKGADIEVKN 389
Cdd:pfam12796  79 LLLEKGADINVKD 91
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 275-396 2.24e-17

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 83.56  E-value: 2.24e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222422842 275 LVDSLLKHNLDINATDVGGLTVLHRAIIGKKQAIT--NYLLRESANPFVLDDEGATLMHYAVQ--TASAPTIKLLLLYNA 350
Cdd:PHA03100  88 IVKLLLEYGANVNAPDNNGITPLLYAISKKSNSYSivEYLLDNGANVNIKNSDGENLLHLYLEsnKIDLKILKLLIDKGV 167

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 222422842 351 DINAQDR----------------DGWTPLHVAVQARRSDIVKLLLIKGADIEVKNKDGLTPL 396
Cdd:PHA03100 168 DINAKNRvnyllsygvpinikdvYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPL 229
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 358-387 3.33e-06

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 43.35  E-value: 3.33e-06
                           10        20        30
                   ....*....|....*....|....*....|
gi 222422842   358 DGWTPLHVAVQARRSDIVKLLLIKGADIEV 387
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 293-398 2.32e-05

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 46.54  E-value: 2.32e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222422842 293 GLTVLHRAIIGKKQAITNYLLRESA---NP------FVLDDEGatLMHY-------AVQTASAPTIKLLLLYNADINAQD 356
Cdd:cd22192   89 GETALHIAVVNQNLNLVRELIARGAdvvSPratgtfFRPGPKN--LIYYgehplsfAACVGNEEIVRLLIEHGADIRAQD 166

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 222422842 357 RDGWTPLHVAVQARRSDIVKLL--LIKGADIE--------VKNKDGLTPLGL 398
Cdd:cd22192  167 SLGNTVLHILVLQPNKTFACQMydLILSYDKEddlqpldlVPNNQGLTPFKL 218
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
236-417 3.47e-37

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 137.39  E-value: 3.47e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222422842 236 KLLSKEEKFMLNSRNPDLAVATSKKWLPLHTLAACGEFYLVDSLLKHNLDINATDVGGLTVLHRAIIGKKQAITNYLLRE 315
Cdd:COG0666   63 LAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEA 142

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222422842 316 SANPFVLDDEGATLMHYAVQTASAPTIKLLLLYNADINAQDRDGWTPLHVAVQARRSDIVKLLLIKGADIEVKNKDGLTP 395
Cdd:COG0666  143 GADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTA 222

                        170       180
                 ....*....|....*....|..
gi 222422842 396 LGLCLYLGREirtyEVMKLLKE 417
Cdd:COG0666  223 LDLAAENGNL----EIVKLLLE 240
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
235-417 8.12e-32

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 122.76  E-value: 8.12e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222422842 235 RKLLSKEEKFMLNSRNPDLAVATSKKWLPLHTLAACGEFYLVDSLLKHNLDINATDVGGLTVLHRAIIGKKQAITNYLLR 314
Cdd:COG0666   29 ALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLE 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222422842 315 ESANPFVLDDEGATLMHYAVQTASAPTIKLLLLYNADINAQDRDGWTPLHVAVQARRSDIVKLLLIKGADIEVKNKDGLT 394
Cdd:COG0666  109 AGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGET 188

                        170       180
                 ....*....|....*....|...
gi 222422842 395 PLGLCLYLGREirtyEVMKLLKE 417
Cdd:COG0666  189 PLHLAAENGHL----EIVKLLLE 207
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
245-427 2.10e-30

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 118.90  E-value: 2.10e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222422842 245 MLNSRNPDLAVATSKKWLPLHTLAACGEFYLVDSLLKHNLDINATDVGGLTVLHRAIIGKKQAITNYLLRESANPFVLDD 324
Cdd:COG0666  105 LLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDN 184

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222422842 325 EGATLMHYAVQTASAPTIKLLLLYNADINAQDRDGWTPLHVAVQARRSDIVKLLLIKGADIEVKNKDGLTPLGLCLYLGR 404
Cdd:COG0666  185 DGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGA 264

                        170       180
                 ....*....|....*....|...
gi 222422842 405 EIRTYEVMKLLKEFPLSRHKKRL 427
Cdd:COG0666  265 ALIVKLLLLALLLLAAALLDLLT 287
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
261-415 1.14e-24

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 103.11  E-value: 1.14e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222422842 261 WLPLHTLAACGEFYLVDSLLKHNLDINATDVGGLTVLHRAIIGKKQAITNYLLRESANPFVLDDEGATLMHYAVQTASAP 340
Cdd:COG0666   22 ALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLE 101

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 222422842 341 TIKLLLLYNADINAQDRDGWTPLHVAVQARRSDIVKLLLIKGADIEVKNKDGLTPLGLCLYLGREirtyEVMKLL 415
Cdd:COG0666  102 IVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNL----EIVKLL 172
Ank_2 pfam12796
Ankyrin repeats (3 copies);
297-389 1.86e-20

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 85.55  E-value: 1.86e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222422842  297 LHRAIIGKKQAITNYLLRESANPFVLDDEGATLMHYAVQTASAPTIKLLLLYnADINAQDrDGWTPLHVAVQARRSDIVK 376
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVK 78

                          90
                  ....*....|...
gi 222422842  377 LLLIKGADIEVKN 389
Cdd:pfam12796  79 LLLEKGADINVKD 91
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
252-396 2.22e-19

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 88.09  E-value: 2.22e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222422842 252 DLAVATSKKWLPLHTLAACGEFYLVDSLLKHNLDINATDVGGLTVLHRAIIGKKQAITNYLLRESANPFVLDDEGATLMH 331
Cdd:COG0666  145 DVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALD 224

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 222422842 332 YAVQTASAPTIKLLLLYNADINAQDRDGWTPLHVAVQARRSDIVKLLLIKGADIEVKNKDGLTPL 396
Cdd:COG0666  225 LAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 275-396 2.24e-17

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 83.56  E-value: 2.24e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222422842 275 LVDSLLKHNLDINATDVGGLTVLHRAIIGKKQAIT--NYLLRESANPFVLDDEGATLMHYAVQ--TASAPTIKLLLLYNA 350
Cdd:PHA03100  88 IVKLLLEYGANVNAPDNNGITPLLYAISKKSNSYSivEYLLDNGANVNIKNSDGENLLHLYLEsnKIDLKILKLLIDKGV 167

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 222422842 351 DINAQDR----------------DGWTPLHVAVQARRSDIVKLLLIKGADIEVKNKDGLTPL 396
Cdd:PHA03100 168 DINAKNRvnyllsygvpinikdvYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPL 229
Ank_2 pfam12796
Ankyrin repeats (3 copies);
330-415 1.27e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 72.07  E-value: 1.27e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222422842  330 MHYAVQTASAPTIKLLLLYNADINAQDRDGWTPLHVAVQARRSDIVKLLLiKGADIEVKNkDGLTPLGLCLYLGReirtY 409
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLL-EHADVNLKD-NGRTALHYAARSGH----L 74


                  ....*.
gi 222422842  410 EVMKLL 415
Cdd:pfam12796  75 EIVKLL 80
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 272-418 2.18e-15

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 78.00  E-value: 2.18e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222422842 272 EFYLVDSLLKHNLDINATDV-GGLTVLHRAIIGKKQAITNYLLRESANPFVLDDEGATLMHYAVQTASAPTIKLLLLYNA 350
Cdd:PHA02878 146 EAEITKLLLSYGADINMKDRhKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGA 225

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222422842 351 DINAQDRDGWTPLHVAVQARRS-DIVKLLLIKGADIEVKNK-DGLTPLGLclylgrEIRTYEVMKLLKEF 418
Cdd:PHA02878 226 STDARDKCGNTPLHISVGYCKDyDILKLLLEHGVDVNAKSYiLGLTALHS------SIKSERKLKLLLEY 289
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
273-417 1.05e-14

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 74.22  E-value: 1.05e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222422842 273 FYLVDSLLKHNLDINATDVGGLTVLHRAIIGKKQAITNYLLRESANPFVLDDEGATLMHYAVQTASAPTIKLLLLYNADI 352
Cdd:COG0666    1 LLLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADI 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 222422842 353 NAQDRDGWTPLHVAVQARRSDIVKLLLIKGADIEVKNKDGLTPLGLCLYLGReirtYEVMKLLKE 417
Cdd:COG0666   81 NAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGN----LEIVKLLLE 141
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 275-396 3.06e-13

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 70.85  E-value: 3.06e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222422842 275 LVDSLLKHNLDINATDVGGLTVLH-----RAIIGKKQAITNYLLRESANPFVLDDEGATLMHYAVQT--ASAPTIKLLLL 347
Cdd:PHA03100  50 VVKILLDNGADINSSTKNNSTPLHylsniKYNLTDVKEIVKLLLEYGANVNAPDNNGITPLLYAISKksNSYSIVEYLLD 129

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 222422842 348 YNADINAQDRDGWTPLHVAVQARRSDI------------------VKLLLIKGADIEVKNKDGLTPL 396
Cdd:PHA03100 130 NGANVNIKNSDGENLLHLYLESNKIDLkilkllidkgvdinaknrVNYLLSYGVPINIKDVYGFTPL 196
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 264-396 4.14e-13

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 70.76  E-value: 4.14e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222422842 264 LHTLAACGEFYLVDSLLKHNLDINATDVGGLTVLHRAIIGKKQAITNYLLRESANPFVLDDEGATLMHYAVQTASAPTIK 343
Cdd:PHA02874 128 LHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIK 207

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 222422842 344 LLLLYNADINAQDRDGWTPLHVAVQARRSDIVklLLIKGADIEVKNKDGLTPL 396
Cdd:PHA02874 208 LLIDHGNHIMNKCKNGFTPLHNAIIHNRSAIE--LLINNASINDQDIDGSTPL 258
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 274-415 6.10e-13

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 70.08  E-value: 6.10e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222422842 274 YLVDSLLKHNLDINATDVGGLTVLHRAIIGKKQAITNYLLRESANPFVLDDEGATLMHY-----AVQTASAPTIKLLLLY 348
Cdd:PHA03100  16 KNIKYIIMEDDLNDYSYKKPVLPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYlsnikYNLTDVKEIVKLLLEY 95

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 222422842 349 NADINAQDRDGWTPLHVAVQARR--SDIVKLLLIKGADIEVKNKDGLTPLGlcLYLGREIRTYEVMKLL 415
Cdd:PHA03100  96 GANVNAPDNNGITPLLYAISKKSnsYSIVEYLLDNGANVNIKNSDGENLLH--LYLESNKIDLKILKLL 162
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 245-390 1.33e-12

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 68.92  E-value: 1.33e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222422842 245 MLNSRNPDLAVATSKKWLPLHTLAAC--GEFYLVDSLLKHNLDINATDVGGLTVLHRAIIGKKQ---------------- 306
Cdd:PHA03100  91 LLLEYGANVNAPDNNGITPLLYAISKksNSYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKIdlkilkllidkgvdin 170

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222422842 307 AIT--NYLLRESANPFVLDDEGATLMHYAVQTASAPTIKLLLLYNADINAQDRDGWTPLHVAVQARRSDIVKLLLIKGAD 384
Cdd:PHA03100 171 AKNrvNYLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPS 250


                 ....*.
gi 222422842 385 IEVKNK 390
Cdd:PHA03100 251 IKTIIE 256
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 323-396 3.02e-12

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 68.07  E-value: 3.02e-12
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 222422842 323 DDEGATLMHYAVQTASAPTIKLLLLYNADINAQDRDGWTPLHVAVQARRSDIVKLLLIKGADIEVKNKDGLTPL 396
Cdd:PHA02874 121 DAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPL 194
PHA03095 PHA03095
ankyrin-like protein; Provisional
 263-396 3.49e-12

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 67.74  E-value: 3.49e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222422842 263 PLHTLAA--CGEFYLVDSLLKHNLDINATDVGGLTVLHrAIIGKKQA---ITNYLLRESANPFVLDDEGATLMHYAVQT- 336
Cdd:PHA03095 120 PLHVYLSgfNINPKVIRLLLRKGADVNALDLYGMTPLA-VLLKSRNAnveLLRLLIDAGADVYAVDDRFRSLLHHHLQSf 198

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 222422842 337 -ASAPTIKLLLLYNADINAQDRDGWTPLHVAV---QARRSDIVKLLlIKGADIEVKNKDGLTPL 396
Cdd:PHA03095 199 kPRARIVRELIRAGCDPAATDMLGNTPLHSMAtgsSCKRSLVLPLL-IAGISINARNRYGQTPL 261
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 242-391 4.60e-12

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 67.97  E-value: 4.60e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222422842 242 EKFMLNSRNPDlaVATSKKWLPLHTLAACGEFYLVDSLLKHNLDINATDVGGLTVLHRAIIGKKQAITN--YLLRESANP 319
Cdd:PLN03192 542 EELLKAKLDPD--IGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRilYHFASISDP 619

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 222422842 320 FVlddeGATLMHYAVQTASAPTIKLLLLYNADINAQDRDGWTPLHVAVQARRSDIVKLLLIKGADIEVKNKD 391
Cdd:PLN03192 620 HA----AGDLLCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADVDKANTD 687
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 270-396 4.71e-12

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 67.30  E-value: 4.71e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222422842 270 CGEFYLVDSLLKHNLDINATDVGGLTVLHRAIIGKKQAITNYLLRESANPFVLDDEGATLMHYAVQTASAPTIKLLLLYN 349
Cdd:PHA02874 101 CIEKDMIKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKG 180

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 222422842 350 ADINAQDRDGWTPLHVAVQARRSDIVKLLLIKGADIEVKNKDGLTPL 396
Cdd:PHA02874 181 AYANVKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPL 227
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 263-406 6.16e-12

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 67.21  E-value: 6.16e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222422842 263 PLHTLAACGEFYLVDSLLKHNLDINATDVGGLTVLHRAIIGKKQAITNYLLRESANPFVLDDEGATLMHYAVQTA-SAPT 341
Cdd:PHA02878 171 ALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHISVGYCkDYDI 250

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 222422842 342 IKLLLLYNADINAQDR-DGWTPLHVAVqaRRSDIVKLLLIKGADIEVKNKDGLTPLGLCL--YLGREI 406
Cdd:PHA02878 251 LKLLLEHGVDVNAKSYiLGLTALHSSI--KSERKLKLLLEYGADINSLNSYKLTPLSSAVkqYLCINI 316
PHA03095 PHA03095
ankyrin-like protein; Provisional
 263-396 1.99e-11

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 65.43  E-value: 1.99e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222422842 263 PLHTLAACG---EFYLVDSLLKHNLDINATDVGGLTVLHRAII-GKKQAITNYLLRESANPFVLDDEGATLMH-Y-AVQT 336
Cdd:PHA03095  50 PLHLYLHYSsekVKDIVRLLLEAGADVNAPERCGFTPLHLYLYnATTLDVIKLLIKAGADVNAKDKVGRTPLHvYlSGFN 129

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 222422842 337 ASAPTIKLLLLYNADINAQDRDGWTPLHVAVQARRSDI--VKLLLIKGADIEVKNKDGLTPL 396
Cdd:PHA03095 130 INPKVIRLLLRKGADVNALDLYGMTPLAVLLKSRNANVelLRLLIDAGADVYAVDDRFRSLL 191
Ank_5 pfam13857
Ankyrin repeats (many copies);
344-396 7.71e-11

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 57.36  E-value: 7.71e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 222422842  344 LLLLYNADINAQDRDGWTPLHVAVQARRSDIVKLLLIKGADIEVKNKDGLTPL 396
Cdd:pfam13857   1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTAL 53
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 263-392 9.09e-11

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 63.47  E-value: 9.09e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222422842 263 PLHTLAACGEFYLVDSLLKHNLDINatDV---GGLTVLHRAIIGKKQAITNYLLRESANPFVLDDEGATLMHYAVQTASA 339
Cdd:PHA02875  71 ELHDAVEEGDVKAVEELLDLGKFAD--DVfykDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDI 148

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 222422842 340 PTIKLLLLYNADINAQDRDGWTPLHVAVQARRSDIVKLLLIKGADIEVKNKDG 392
Cdd:PHA02875 149 KGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNG 201
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 190-412 1.82e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 62.77  E-value: 1.82e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222422842 190 AVSSPS-ERVAPKnprwaVYGKGFDHVAKffnsdkydpsDKKSDGPRKLLSK-----EEKFMLNSRNPDLAVATSKKWLP 263
Cdd:PHA02876 280 ASQAPSlSRLVPK-----LLERGADVNAK----------NIKGETPLYLMAKngydtENIRTLIMLGADVNAADRLYITP 344

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222422842 264 LHTLAACGEFY-LVDSLLKHNLDINATDVGGLTVLHRAIIGKKQAITNYLLRESANPFVLDDEGATLMHYAV-QTASAPT 341
Cdd:PHA02876 345 LHQASTLDRNKdIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTALHFALcGTNPYMS 424

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222422842 342 IKLLLLYNADINAQDRDGWTPLHVAVQAR-RSDIVKLLLIKGADIEVKNKDGLTPL----------GLCLYLGREIRTYE 410
Cdd:PHA02876 425 VKTLIDRGANVNSKNKDLSTPLHYACKKNcKLDVIEMLLDNGADVNAINIQNQYPLlialeyhgivNILLHYGAELRDSR 504


                 ..
gi 222422842 411 VM 412
Cdd:PHA02876 505 VL 506
PHA03095 PHA03095
ankyrin-like protein; Provisional
 308-400 2.80e-10

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 61.96  E-value: 2.80e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222422842 308 ITNYLLRESANPFVLDDEGATLMHYAVQTASAP---TIKLLLLYNADINAQDRDGWTPLHVAVQ-ARRSDIVKLLLIKGA 383
Cdd:PHA03095  29 EVRRLLAAGADVNFRGEYGKTPLHLYLHYSSEKvkdIVRLLLEAGADVNAPERCGFTPLHLYLYnATTLDVIKLLIKAGA 108

                         90
                 ....*....|....*..
gi 222422842 384 DIEVKNKDGLTPLGLCL 400
Cdd:PHA03095 109 DVNAKDKVGRTPLHVYL 125
Ank_4 pfam13637
Ankyrin repeats (many copies);
328-379 3.96e-10

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 54.97  E-value: 3.96e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 222422842  328 TLMHYAVQTASAPTIKLLLLYNADINAQDRDGWTPLHVAVQARRSDIVKLLL 379
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 272-398 1.31e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 60.08  E-value: 1.31e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222422842 272 EFYLVDSLLKHNLDINATDVGGLTVLHRAIIGKKQAITNYLLRESANPFVLDDEGATLMHYAVQTASAPTIKL------- 344
Cdd:PHA02876 157 ELLIAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAiidnrsn 236

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 222422842 345 --------------------LLLYNA--DINAQDRDGWTPLHVAVQARR-SDIVKLLLIKGADIEVKNKDGLTPLGL 398
Cdd:PHA02876 237 inkndlsllkairnedletsLLLYDAgfSVNSIDDCKNTPLHHASQAPSlSRLVPKLLERGADVNAKNIKGETPLYL 313
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 263-379 4.34e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 58.05  E-value: 4.34e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222422842 263 PLHTLAACGEFYLVDSLLKHNLDINATDVGGLTVLHRAIIGKKQAITnyLLRESANPFVLDDEGATLMHYAVQ-TASAPT 341
Cdd:PHA02874 193 PLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIIHNRSAIE--LLINNASINDQDIDGSTPLHHAINpPCDIDI 270

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 222422842 342 IKLLLLYNADINAQDRDGWTPLHVAVQ-ARRSDIVKLLL 379
Cdd:PHA02874 271 IDILLYHKADISIKDNKGENPIDTAFKyINKDPVIKDII 309
PHA03095 PHA03095
ankyrin-like protein; Provisional
 275-396 5.60e-09

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 57.73  E-value: 5.60e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222422842 275 LVDSLLKHNLDINATDVGGLTVLHRAI--IGKKQAITNYLLRESANPFVLDDEGATLMHYAVQTASAPTIKL--LLLYNA 350
Cdd:PHA03095 169 LLRLLIDAGADVYAVDDRFRSLLHHHLqsFKPRARIVRELIRAGCDPAATDMLGNTPLHSMATGSSCKRSLVlpLLIAGI 248

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 222422842 351 DINAQDRDGWTPLHVAVqARRSDIVKLLLIK-GADIEVKNKDGLTPL 396
Cdd:PHA03095 249 SINARNRYGQTPLHYAA-VFNNPRACRRLIAlGADINAVSSDGNTPL 294
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
243-363 8.46e-09

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 56.50  E-value: 8.46e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222422842 243 KFMLNsRNPDLAVATSKKWLPLHTLAACGEFYLVDSLLKHNLDINATDVGGLTVLHRAIIGKKQAITNYLLRESANPFVL 322
Cdd:COG0666  170 KLLLE-AGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAK 248

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 222422842 323 DDEGATLMHYAVQTASAPTIKLLLLYNADINAQDRDGWTPL 363
Cdd:COG0666  249 DKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
PHA03095 PHA03095
ankyrin-like protein; Provisional
 336-415 3.79e-08

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 55.42  E-value: 3.79e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222422842 336 TASAPTIKLLLLYNADINAQDRDGWTPLHVAVQAR---RSDIVKLLLIKGADIEVKNKDGLTPLGLCLYLGREIrtyEVM 412
Cdd:PHA03095  24 NVTVEEVRRLLAAGADVNFRGEYGKTPLHLYLHYSsekVKDIVRLLLEAGADVNAPERCGFTPLHLYLYNATTL---DVI 100


                 ...
gi 222422842 413 KLL 415
Cdd:PHA03095 101 KLL 103
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 315-423 1.07e-07

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 54.13  E-value: 1.07e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222422842 315 ESANPFVLDDEGATLMHYAVqTASAPTIKLLLLYNADINAQDRDGWTPLHVAVQARRSDIVKLLLIKGADIEVKNKDGLT 394
Cdd:PTZ00322  72 EVIDPVVAHMLTVELCQLAA-SGDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKT 150

                         90       100
                 ....*....|....*....|....*....
gi 222422842 395 PLGlclyLGREIRTYEVMKLLKEFPLSRH 423
Cdd:PTZ00322 151 PLE----LAEENGFREVVQLLSRHSQCHF 175
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 264-403 1.10e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 53.84  E-value: 1.10e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222422842 264 LHTLAAC-----GEFYLVDSLLKHNLDINATDVGGLTVLHRAIIGKKQAITNYLLRESANPFVLDDEGATLMHYAVQTAS 338
Cdd:PHA02875   1 MDQVALCdailfGELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGD 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 222422842 339 APTIKLLLLYNADIN-AQDRDGWTPLHVAVQARRSDIVKLLLIKGADIEVKNKDGLTPLGLCLYLG 403
Cdd:PHA02875  81 VKAVEELLDLGKFADdVFYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMG 146
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 312-379 1.44e-07

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 53.75  E-value: 1.44e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 222422842 312 LLRESANPFVLDDEGATLMHYAVQTASAPTIKLLLLYNADINAQDRDGWTPLHVAVQARRSDIVKLLL 379
Cdd:PTZ00322 101 LLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLS 168
Ank_5 pfam13857
Ankyrin repeats (many copies);
311-366 1.65e-07

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 47.73  E-value: 1.65e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 222422842  311 YLLRESANPFVLDDEGATLMHYAVQTASAPTIKLLLLYNADINAQDRDGWTPLHVA 366
Cdd:pfam13857   1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 358-390 2.92e-07

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 46.51  E-value: 2.92e-07
                          10        20        30
                  ....*....|....*....|....*....|....
gi 222422842  358 DGWTPLHVAV-QARRSDIVKLLLIKGADIEVKNK 390
Cdd:pfam00023   1 DGNTPLHLAAgRRGNLEIVKLLLSKGADVNARDK 34
Ank_4 pfam13637
Ankyrin repeats (many copies);
359-415 3.27e-07

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 46.88  E-value: 3.27e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 222422842  359 GWTPLHVAVQARRSDIVKLLLIKGADIEVKNKDGLTPLGLCLYLGReirtYEVMKLL 415
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGN----VEVLKLL 53
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 279-396 3.79e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 51.92  E-value: 3.79e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222422842 279 LLKHNLDINATDVGGLTVLHRAII-GKKQAITNYLLRESANPFVLDDEGATLMHYAVQTASAPTIKLLLLYNADINAQDR 357
Cdd:PHA02875  54 LMKHGAIPDVKYPDIESELHDAVEeGDVKAVEELLDLGKFADDVFYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNT 133

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 222422842 358 DGWTPLHVAVQARRSDIVKLLLIKGADIEVKNKDGLTPL 396
Cdd:PHA02875 134 DKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPL 172
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 215-353 2.78e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 49.22  E-value: 2.78e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222422842 215 VAKFFNSDKY--DPSDKKSDGPRKLLSKEEKF----MLNSRNPDLAVATSKKWLPLHTLAACGEFYLVDSLLKHNLDINA 288
Cdd:PHA02875  84 VEELLDLGKFadDVFYKDGMTPLHLATILKKLdimkLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDI 163

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 222422842 289 TDVGGLTVLHRAIIGKKQAITNYLLRESANP-FVLDDEGATLMHYAVQTASAPTIKLLLLYNADIN 353
Cdd:PHA02875 164 EDCCGCTPLIIAMAKGDIAICKMLLDSGANIdYFGKNGCVAALCYAIENNKIDIVRLFIKRGADCN 229
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 358-387 3.33e-06

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 43.35  E-value: 3.33e-06
                           10        20        30
                   ....*....|....*....|....*....|
gi 222422842   358 DGWTPLHVAVQARRSDIVKLLLIKGADIEV 387
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
Ank_5 pfam13857
Ankyrin repeats (many copies);
279-333 3.73e-06

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 43.87  E-value: 3.73e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 222422842  279 LLKH-NLDINATDVGGLTVLHRAIIGKKQAITNYLLRESANPFVLDDEGATLMHYA 333
Cdd:pfam13857   1 LLEHgPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
Ank_4 pfam13637
Ankyrin repeats (many copies);
261-313 8.68e-06

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 43.03  E-value: 8.68e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 222422842  261 WLPLHTLAACGEFYLVDSLLKHNLDINATDVGGLTVLHRAIIGKKQAITNYLL 313
Cdd:pfam13637   2 LTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02917 PHA02917
ankyrin-like protein; Provisional
 325-415 1.84e-05

ankyrin-like protein; Provisional


Pssm-ID: 165231 [Multi-domain]  Cd Length: 661  Bit Score: 46.91  E-value: 1.84e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222422842 325 EGATLMHYAVQTASapTIKLLLLYNADINAQDRDGWTPLHVAVQARRSDIVKLLLIKGADIEVKNKDGLTPLGLCLylgR 404
Cdd:PHA02917 420 KGLCDMSYACPILS--TINICLPYLKDINMIDKRGETLLHKAVRYNKQSLVSLLLESGSDVNIRSNNGYTCIAIAI---N 494

                         90
                 ....*....|.
gi 222422842 405 EIRTYEVMKLL 415
Cdd:PHA02917 495 ESRNIELLKML 505
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 358-387 2.30e-05

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 41.09  E-value: 2.30e-05
                          10        20        30
                  ....*....|....*....|....*....|
gi 222422842  358 DGWTPLHVAVQARRSDIVKLLLIKGADIEV 387
Cdd:pfam13606   1 DGNTPLHLAARNGRLEIVKLLLENGADINA 30
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 293-398 2.32e-05

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 46.54  E-value: 2.32e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222422842 293 GLTVLHRAIIGKKQAITNYLLRESA---NP------FVLDDEGatLMHY-------AVQTASAPTIKLLLLYNADINAQD 356
Cdd:cd22192   89 GETALHIAVVNQNLNLVRELIARGAdvvSPratgtfFRPGPKN--LIYYgehplsfAACVGNEEIVRLLIEHGADIRAQD 166

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 222422842 357 RDGWTPLHVAVQARRSDIVKLL--LIKGADIE--------VKNKDGLTPLGL 398
Cdd:cd22192  167 SLGNTVLHILVLQPNKTFACQMydLILSYDKEddlqpldlVPNNQGLTPFKL 218
Ank_4 pfam13637
Ankyrin repeats (many copies);
293-346 3.50e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 41.11  E-value: 3.50e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 222422842  293 GLTVLHRAIIGKKQAITNYLLRESANPFVLDDEGATLMHYAVQTASAPTIKLLL 346
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
TRPV3 cd22194
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a ...
 347-390 9.90e-05

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a temperature-sensitive Transient Receptor Potential (TRP) ion channel that is activated by warm temperatures, synthetic small-molecule chemicals, and natural compounds from plants. TRPV3 function is regulated by physiological factors such as extracellular divalent cations and acidic pH, intracellular adenosine triphosphate, membrane voltage, and arachidonic acid. It is expressed in both neuronal and non-neuronal tissues including epidermal keratinocytes, epithelial cells in the gut, endothelial cells in blood vessels, and neurons in dorsal root ganglia and CNS. TRPV3 null mice have abnormal hair morphogenesis and compromised skin barrier function. It may play roles in inflammatory skin disorders, such as itch and pain sensation. TRPV3 is also expressed by many neuronal and non-neuronal tissues, showing that TRPV3 might play roles in other unknown cellular and physiological functions. TRPV3 belongs to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all TRP ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411978 [Multi-domain]  Cd Length: 680  Bit Score: 44.75  E-value: 9.90e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 222422842 347 LYNADINAQDRDGWTPLHVAVQARRSDIVKLLLIKGADIEVKNK 390
Cdd:cd22194  129 FINAEYTEEAYEGQTALNIAIERRQGDIVKLLIAKGADVNAHAK 172
PHA02741 PHA02741
hypothetical protein; Provisional
 311-418 1.09e-04

hypothetical protein; Provisional


Pssm-ID: 165108 [Multi-domain]  Cd Length: 169  Bit Score: 42.72  E-value: 1.09e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222422842 311 YLLResanpfVLDDEGATLMHYAVQT----ASAPTIKLLLLYNADINAQDR-DGWTPLHVAVQARRSDIVKLLLIK-GAD 384
Cdd:PHA02741  51 AALN------ATDDAGQMCIHIAAEKheaqLAAEIIDHLIELGADINAQEMlEGDTALHLAAHRRDHDLAEWLCCQpGID 124

                         90       100       110
                 ....*....|....*....|....*....|....
gi 222422842 385 IEVKNKDGLTPlglcLYLGREIRTYEVMKLLKEF 418
Cdd:PHA02741 125 LHFCNADNKSP----FELAIDNEDVAMMQILREI 154
PHA02736 PHA02736
Viral ankyrin protein; Provisional
 342-417 1.42e-04

Viral ankyrin protein; Provisional


Pssm-ID: 165103 [Multi-domain]  Cd Length: 154  Bit Score: 42.17  E-value: 1.42e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 222422842 342 IKLLLLYNADINAQDR-DGWTPLHVAVQARRSDIVKLLLIK-GADIEVKNKDGLTPlglcLYLGREIRTYEVMKLLKE 417
Cdd:PHA02736  74 LKLLMEWGADINGKERvFGNTPLHIAVYTQNYELATWLCNQpGVNMEILNYAFKTP----YYVACERHDAKMMNILRA 147
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 324-387 2.82e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 43.03  E-value: 2.82e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 222422842 324 DEGATLMHYAVQTASAPTIKLLLLYNADINAQDRDGWTPLHVAVQARRSDIVKLLLIKGADIEV 387
Cdd:PHA02874  33 DETTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIDNGVDTSI 96
PHA02798 PHA02798
ankyrin-like protein; Provisional
 309-412 8.47e-04

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 41.74  E-value: 8.47e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222422842 309 TNYLLRESANPFVLDDEGATLMHYAVQ-TASAPTIKLLLLYNADINAQDRDGWTPL-----HVAVQARRSDIVKLLLIKG 382
Cdd:PHA02798  20 TVKLLIKSCNPNEIVNEYSIFQKYLQRdSPSTDIVKLFINLGANVNGLDNEYSTPLctilsNIKDYKHMLDIVKILIENG 99

                         90       100       110
                 ....*....|....*....|....*....|
gi 222422842 383 ADIEVKNKDGLTPLgLCLYLGREIRTYEVM 412
Cdd:PHA02798 100 ADINKKNSDGETPL-YCLLSNGYINNLEIL 128
PHA02859 PHA02859
ankyrin repeat protein; Provisional
 308-392 1.49e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165195 [Multi-domain]  Cd Length: 209  Bit Score: 39.80  E-value: 1.49e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222422842 308 ITNYLLRESAN-PFVLDDEGATLMHYAV---QTASAPTIKLLLLYNADINAQDRDGWTPLHVAVQ--ARRSDIVKLLLIK 381
Cdd:PHA02859  68 ILKFLIENGADvNFKTRDNNLSALHHYLsfnKNVEPEILKILIDSGSSITEEDEDGKNLLHMYMCnfNVRINVIKLLIDS 147

                         90
                 ....*....|.
gi 222422842 382 GADIEVKNKDG 392
Cdd:PHA02859 148 GVSFLNKDFDN 158
PHA03095 PHA03095
ankyrin-like protein; Provisional
 245-328 2.20e-03

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 40.39  E-value: 2.20e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222422842 245 MLNSRNPDLAVATSKKWLPLHTLAACGEFY--LVDSLLKHNLDINATDVGGLTVLHRAIIGKKQAITNYLLRESANPFVL 322
Cdd:PHA03095 207 ELIRAGCDPAATDMLGNTPLHSMATGSSCKrsLVLPLLIAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAV 286


                 ....*.
gi 222422842 323 DDEGAT 328
Cdd:PHA03095 287 SSDGNT 292
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 263-349 2.95e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 39.86  E-value: 2.95e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222422842 263 PLH-TLAACGEFYLVDSLLKHNLDINA-TDVGGLTVLHRAIigKKQAITNYLLRESANPFVLDDEGATLMHYAVQTASAP 340
Cdd:PHA02878 237 PLHiSVGYCKDYDILKLLLEHGVDVNAkSYILGLTALHSSI--KSERKLKLLLEYGADINSLNSYKLTPLSSAVKQYLCI 314


                 ....*....
gi 222422842 341 TIKLLLLYN 349
Cdd:PHA02878 315 NIGRILISN 323
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 227-348 3.06e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 39.88  E-value: 3.06e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222422842 227 SDKKSDGPRKLLSKEEkfmlnSRNPDLAVATSkkwLPLHTLAACGEFYLVDSLLKHNLDINATDVGGLTVLHRAIIGKKQ 306
Cdd:PTZ00322  57 TENKDATPDHNLTTEE-----VIDPVVAHMLT---VELCQLAASGDAVGARILLTGGADPNCRDYDGRTPLHIACANGHV 128

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 222422842 307 AITNYLLRESANPFVLDDEGATLMHYAVQTASAPTIKLLLLY 348
Cdd:PTZ00322 129 QVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRH 170
TRPV1-4 cd22193
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 1-4; TRPV1-4 are ...
 340-429 3.26e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 1-4; TRPV1-4 are thermo-sensing channels that function directly in temperature-sensing and nociception; they share substantial structural and functional properties. Transient Receptor Potential (TRP) ion channels activated by temperature (thermo TRPs) are important molecular players in acute, inflammatory, and chronic pain states. So far, 11 TRP channels in mammalian cells have been identified as thermosensitive TRP (thermo-TRP) channels. TRPV1-4 channels are activated by different heat temperatures, for example, TRPV1 and TRPV2 are activated by high temperatures (>43C and >55C, respectively). TRPV1-4 belong to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all TRP ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411977 [Multi-domain]  Cd Length: 607  Bit Score: 39.78  E-value: 3.26e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222422842 340 PTIKLLLLYN----ADINAQDRDGWTPLHVAVQA-----RRSDIVK----LLLIKGADI-------EVKNKDGLTPLGLC 399
Cdd:cd22193  136 PDIVQYLLENehqpADIEAQDSRGNTVLHALVTVadntkENTKFVTrmydMILIRGAKLcptveleEIRNNDGLTPLQLA 215

                         90       100       110
                 ....*....|....*....|....*....|.
gi 222422842 400 LYLGR-EIRTYEVMKLLKEfPLSRHKKRLVT 429
Cdd:cd22193  216 AKMGKiEILKYILQREIKE-PELRHLSRKFT 245
TRPV3 cd22194
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a ...
 293-434 3.66e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a temperature-sensitive Transient Receptor Potential (TRP) ion channel that is activated by warm temperatures, synthetic small-molecule chemicals, and natural compounds from plants. TRPV3 function is regulated by physiological factors such as extracellular divalent cations and acidic pH, intracellular adenosine triphosphate, membrane voltage, and arachidonic acid. It is expressed in both neuronal and non-neuronal tissues including epidermal keratinocytes, epithelial cells in the gut, endothelial cells in blood vessels, and neurons in dorsal root ganglia and CNS. TRPV3 null mice have abnormal hair morphogenesis and compromised skin barrier function. It may play roles in inflammatory skin disorders, such as itch and pain sensation. TRPV3 is also expressed by many neuronal and non-neuronal tissues, showing that TRPV3 might play roles in other unknown cellular and physiological functions. TRPV3 belongs to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all TRP ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411978 [Multi-domain]  Cd Length: 680  Bit Score: 39.74  E-value: 3.66e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222422842 293 GLTVLHRAIIGKKQAITNYLLRESA-----------NPfVLDDEGATLMHYAVQTASA---PTIKLLLLYNA--DINAQD 356
Cdd:cd22194  141 GQTALNIAIERRQGDIVKLLIAKGAdvnahakgvffNP-KYKHEGFYFGETPLALAACtnqPEIVQLLMEKEstDITSQD 219

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222422842 357 RDGWTPLHVAVQA-----RRSDIVK------LLLIKGADIE-VKNKDGLTPLGLCL----------YLGREIRTYEVMKL 414
Cdd:cd22194  220 SRGNTVLHALVTVaedskTQNDFVKrmydmiLLKSENKNLEtIRNNEGLTPLQLAAkmgkaeilkyILSREIKEKPNRSL 299

                        170       180
                 ....*....|....*....|....*...
gi 222422842 415 LKEF------PLSRHKKRL--VTTDEDI 434
Cdd:cd22194  300 SRKFtdwaygPVSSSLYDLtnVDTTTDN 327
Ank_5 pfam13857
Ankyrin repeats (many copies);
245-300 3.75e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 35.40  E-value: 3.75e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 222422842  245 MLNSRNPDLAVATSKKWLPLHTLAACGEFYLVDSLLKHNLDINATDVGGLTVLHRA 300
Cdd:pfam13857   1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PHA02884 PHA02884
ankyrin repeat protein; Provisional
 295-400 5.23e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165212 [Multi-domain]  Cd Length: 300  Bit Score: 38.81  E-value: 5.23e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222422842 295 TVLHRAIIGKKQAITNYLLRESANP---FVLDDEG-ATLMHYAVQTASAPTIKLLLLYNADINAQDRDG-WTPLHVAVQA 369
Cdd:PHA02884  35 NILYSSIKFHYTDIIDAILKLGADPeapFPLSENSkTNPLIYAIDCDNDDAAKLLIRYGADVNRYAEEAkITPLYISVLH 114

                         90       100       110
                 ....*....|....*....|....*....|.
gi 222422842 370 RRSDIVKLLLIKGADIEVKNKDGLTPLGLCL 400
Cdd:PHA02884 115 GCLKCLEILLSYGADINIQTNDMVTPIELAL 145
PHA02792 PHA02792
ankyrin-like protein; Provisional
 342-402 7.67e-03

ankyrin-like protein; Provisional


Pssm-ID: 165155 [Multi-domain]  Cd Length: 631  Bit Score: 38.78  E-value: 7.67e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 222422842 342 IKLLLLYNADINAQDRDGWTPLHVAVQARRSDIVKLLLIKGADIEVKNKDGLTPLGLCLYL 402
Cdd:PHA02792 393 LKLCKPYIDDINKIDKHGRSILYYCIESHSVSLVEWLIDNGADINITTKYGSTCIGICVIL 453
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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