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Conserved domains on  [gi|693900361|dbj|BAP69466|]
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she9 MDM33 super family [Kluyveromyces marxianus]

Protein Classification

sensitive to high expression protein 9 homolog( domain architecture ID 11157834)

mitochondrial sensitive to high expression protein 9 (She9/Mdm33) homolog is required for the maintenance of the structure of the mitochondrial inner membrane

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
She9_MDM33 pfam05546
She9 / Mdm33 family; Members of this family are mitochondrial inner membrane proteins with a ...
 120-317 3.65e-118

She9 / Mdm33 family; Members of this family are mitochondrial inner membrane proteins with a role in inner mitochondrial membrane organization and biogenesis.


:

Pssm-ID: 428516 [Multi-domain]  Cd Length: 198  Bit Score: 342.25  E-value: 3.65e-118
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693900361  120 WARKMELYLDSLQETIFTATRALNDVTGYSSIQTLRNTIELLEKELKDTKKLVNEAKDQYDTAIKARSESQKEVNELLQR 199
Cdd:pfam05546   1 LSKKLEFYLDSLQETIFTATRALNDVTGYSSIEKLKKSIEELEAELEAAKEEVREAKLAYKDAIARRSASQREVNELLQR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693900361  200 KHSWTPSDLERFTQLYKDDAENLQLQEQAKERLGELEAKEEEISTNLYRAILTRYHEEQIWSDKIRRTSTWGTFILMGVN 279
Cdd:pfam05546  81 KHSWSPTDLERFTELYRNDHANEQEEAEAKEKLTEAEAKEERLSDELYRSILTRYHEEQIWSDKIRRASTWGTWGLMGVN 160

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 693900361  280 ILFFFVFQLLLEPWKRRRLVGSFEDKVKKALDDHQKEQ 317
Cdd:pfam05546 161 VLLFVVAQLLVEPWKRRRLVRSFEEKVKEALEEVSEEL 198
 
Name Accession Description Interval E-value
She9_MDM33 pfam05546
She9 / Mdm33 family; Members of this family are mitochondrial inner membrane proteins with a ...
 120-317 3.65e-118

She9 / Mdm33 family; Members of this family are mitochondrial inner membrane proteins with a role in inner mitochondrial membrane organization and biogenesis.


Pssm-ID: 428516 [Multi-domain]  Cd Length: 198  Bit Score: 342.25  E-value: 3.65e-118
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693900361  120 WARKMELYLDSLQETIFTATRALNDVTGYSSIQTLRNTIELLEKELKDTKKLVNEAKDQYDTAIKARSESQKEVNELLQR 199
Cdd:pfam05546   1 LSKKLEFYLDSLQETIFTATRALNDVTGYSSIEKLKKSIEELEAELEAAKEEVREAKLAYKDAIARRSASQREVNELLQR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693900361  200 KHSWTPSDLERFTQLYKDDAENLQLQEQAKERLGELEAKEEEISTNLYRAILTRYHEEQIWSDKIRRTSTWGTFILMGVN 279
Cdd:pfam05546  81 KHSWSPTDLERFTELYRNDHANEQEEAEAKEKLTEAEAKEERLSDELYRSILTRYHEEQIWSDKIRRASTWGTWGLMGVN 160

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 693900361  280 ILFFFVFQLLLEPWKRRRLVGSFEDKVKKALDDHQKEQ 317
Cdd:pfam05546 161 VLLFVVAQLLVEPWKRRRLVRSFEEKVKEALEEVSEEL 198
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
71-259 4.48e-05

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 45.78  E-value: 4.48e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693900361  71 QLDKAQKSIQDANEKLA--RMENDSHDSNLNFN-AEGKIKDLPSERERHRKKwARKMELYLDSLQETIFTATRALNDVTG 147
Cdd:COG3206  183 QLPELRKELEEAEAALEefRQKNGLVDLSEEAKlLLQQLSELESQLAEARAE-LAEAEARLAALRAQLGSGPDALPELLQ 261

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693900361 148 YSSIQTLRNTIELLEKELKDtkkLVNEAKDQYDTAIKARSEsQKEVNELLQRKHSWTPSDLERFTQLYKDDAENLQLQ-E 226
Cdd:COG3206  262 SPVIQQLRAQLAELEAELAE---LSARYTPNHPDVIALRAQ-IAALRAQLQQEAQRILASLEAELEALQAREASLQAQlA 337

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 693900361 227 QAKERLGELEAKEEE---------ISTNLYRAILTRYHEEQI 259
Cdd:COG3206  338 QLEARLAELPELEAElrrlereveVARELYESLLQRLEEARL 379
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
105-257 6.87e-03

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 38.89  E-value: 6.87e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693900361 105 KIKDLPSERERHRKKWA--RKMELYLDSLQETIFTATRALNDVTGY-----SSIQTLRNTIELLEKELKDTKKLVNEAK- 176
Cdd:PRK03918 208 EINEISSELPELREELEklEKEVKELEELKEEIEELEKELESLEGSkrkleEKIRELEERIEELKKEIEELEEKVKELKe 287

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693900361 177 -----DQYDTAIKARSESQKEVNELLQRkhswtpsdLERFTQLYKDDAENLQLQEQAKERLGELEAKEEEISTNLyrAIL 251
Cdd:PRK03918 288 lkekaEEYIKLSEFYEEYLDELREIEKR--------LSRLEEEINGIEERIKELEEKEERLEELKKKLKELEKRL--EEL 357


                 ....*.
gi 693900361 252 TRYHEE 257
Cdd:PRK03918 358 EERHEL 363
 
Name Accession Description Interval E-value
She9_MDM33 pfam05546
She9 / Mdm33 family; Members of this family are mitochondrial inner membrane proteins with a ...
 120-317 3.65e-118

She9 / Mdm33 family; Members of this family are mitochondrial inner membrane proteins with a role in inner mitochondrial membrane organization and biogenesis.


Pssm-ID: 428516 [Multi-domain]  Cd Length: 198  Bit Score: 342.25  E-value: 3.65e-118
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693900361  120 WARKMELYLDSLQETIFTATRALNDVTGYSSIQTLRNTIELLEKELKDTKKLVNEAKDQYDTAIKARSESQKEVNELLQR 199
Cdd:pfam05546   1 LSKKLEFYLDSLQETIFTATRALNDVTGYSSIEKLKKSIEELEAELEAAKEEVREAKLAYKDAIARRSASQREVNELLQR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693900361  200 KHSWTPSDLERFTQLYKDDAENLQLQEQAKERLGELEAKEEEISTNLYRAILTRYHEEQIWSDKIRRTSTWGTFILMGVN 279
Cdd:pfam05546  81 KHSWSPTDLERFTELYRNDHANEQEEAEAKEKLTEAEAKEERLSDELYRSILTRYHEEQIWSDKIRRASTWGTWGLMGVN 160

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 693900361  280 ILFFFVFQLLLEPWKRRRLVGSFEDKVKKALDDHQKEQ 317
Cdd:pfam05546 161 VLLFVVAQLLVEPWKRRRLVRSFEEKVKEALEEVSEEL 198
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
71-259 4.48e-05

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 45.78  E-value: 4.48e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693900361  71 QLDKAQKSIQDANEKLA--RMENDSHDSNLNFN-AEGKIKDLPSERERHRKKwARKMELYLDSLQETIFTATRALNDVTG 147
Cdd:COG3206  183 QLPELRKELEEAEAALEefRQKNGLVDLSEEAKlLLQQLSELESQLAEARAE-LAEAEARLAALRAQLGSGPDALPELLQ 261

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693900361 148 YSSIQTLRNTIELLEKELKDtkkLVNEAKDQYDTAIKARSEsQKEVNELLQRKHSWTPSDLERFTQLYKDDAENLQLQ-E 226
Cdd:COG3206  262 SPVIQQLRAQLAELEAELAE---LSARYTPNHPDVIALRAQ-IAALRAQLQQEAQRILASLEAELEALQAREASLQAQlA 337

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 693900361 227 QAKERLGELEAKEEE---------ISTNLYRAILTRYHEEQI 259
Cdd:COG3206  338 QLEARLAELPELEAElrrlereveVARELYESLLQRLEEARL 379
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 71-241 2.60e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 42.89  E-value: 2.60e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693900361  71 QLDKAQKSIQDANEKLARMENDSHDsnlnfnAEGKIKDLPSERERHR---KKWARkmelyldSLQETIFTATrALNDVTG 147
Cdd:COG3883   45 ELEELNEEYNELQAELEALQAEIDK------LQAEIAEAEAEIEERReelGERAR-------ALYRSGGSVS-YLDVLLG 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693900361 148 YSSIQTLRNTIELLEKELKDTKKLVNEAKDQYDTAIKARSESQKEVNELLQRKhswtpSDLERftqlYKDDAEnlQLQEQ 227
Cdd:COG3883  111 SESFSDFLDRLSALSKIADADADLLEELKADKAELEAKKAELEAKLAELEALK-----AELEA----AKAELE--AQQAE 179

                        170
                 ....*....|....
gi 693900361 228 AKERLGELEAKEEE 241
Cdd:COG3883  180 QEALLAQLSAEEAA 193
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 67-266 1.24e-03

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 40.29  E-value: 1.24e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693900361  67 NLKIQLDKAQKSIQDANEKLArmendshdsnlnfNAEGKIKDLpsERERHRKkwarkmELYLDSLQETIFTATRALNDVT 146
Cdd:COG1579   28 ELPAELAELEDELAALEARLE-------------AAKTELEDL--EKEIKRL------ELEIEEVEARIKKYEEQLGNVR 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693900361 147 GYSSIQTLRNTIELLEKELKDTKKLVNEAKDQYDTAIKARSESQKEVNELLQrkhswtpsDLERFTQLYKDDAENLQlqe 226
Cdd:COG1579   87 NNKEYEALQKEIESLKRRISDLEDEILELMERIEELEEELAELEAELAELEA--------ELEEKKAELDEELAELE--- 155

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 693900361 227 qakERLGELEAKEEEISTNLYRAILTRYheeqiwsDKIRR 266
Cdd:COG1579  156 ---AELEELEAEREELAAKIPPELLALY-------ERIRK 185
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 111-270 2.01e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 40.69  E-value: 2.01e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693900361 111 SERERHRKKWA-----RKMELYLDSLQETIFTATRALNDVTgySSIQTLRNTIELLEKELKDTKKLVNEAKDQYDTAIKA 185
Cdd:COG1196  219 KEELKELEAELlllklRELEAELEELEAELEELEAELEELE--AELAELEAELEELRLELEELELELEEAQAEEYELLAE 296

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693900361 186 RSESQKEVNELLQRKHSwtpsDLERFTQLYKDDAENLQLQEQAKERLGELEAKEEEISTNLYRAILTRYHEEQIWSDKIR 265
Cdd:COG1196  297 LARLEQDIARLEERRRE----LEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEA 372


                 ....*
gi 693900361 266 RTSTW 270
Cdd:COG1196  373 ELAEA 377
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
71-249 2.14e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 40.28  E-value: 2.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693900361   71 QLDKAQKSIQDANEKLARMEndshdsnlnfnaegkikDLPSERERHRKKWARKMEL-YLDSLQEtIFTATRALNDVTgyS 149
Cdd:COG4913   236 DLERAHEALEDAREQIELLE-----------------PIRELAERYAAARERLAELeYLRAALR-LWFAQRRLELLE--A 295

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693900361  150 SIQTLRNTIELLEKELKDTKKLVNEAKDQYDTAIKARSES--------QKEVNELLQRKHSWTpSDLERFTQL------- 214
Cdd:COG4913   296 ELEELRAELARLEAELERLEARLDALREELDELEAQIRGNggdrleqlEREIERLERELEERE-RRRARLEALlaalglp 374

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 693900361  215 YKDDAENLQ-LQEQAKERLGELEAKEEEISTNLYRA 249
Cdd:COG4913   375 LPASAEEFAaLRAEAAALLEALEEELEALEEALAEA 410
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 100-258 4.43e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 38.98  E-value: 4.43e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693900361 100 FNAEGKIKDLPSERERHRKKWARKMELyLDSLQETIFTATRALNDVTgySSIQTLRNTIELLEKELKDTKKLVNEAKDQY 179
Cdd:COG4942   16 AAQADAAAEAEAELEQLQQEIAELEKE-LAALKKEEKALLKQLAALE--RRIAALARRIRALEQELAALEAELAELEKEI 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693900361 180 DTAIKARSESQKEVNELL---QRK----------HSWTPSDLERFTQLYKDDAENLQLQ-EQAKERLGELEAKEEEISTN 245
Cdd:COG4942   93 AELRAELEAQKEELAELLralYRLgrqpplalllSPEDFLDAVRRLQYLKYLAPARREQaEELRADLAELAALRAELEAE 172

                        170
                 ....*....|...
gi 693900361 246 lyRAILTRYHEEQ 258
Cdd:COG4942  173 --RAELEALLAEL 183
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
105-257 6.87e-03

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 38.89  E-value: 6.87e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693900361 105 KIKDLPSERERHRKKWA--RKMELYLDSLQETIFTATRALNDVTGY-----SSIQTLRNTIELLEKELKDTKKLVNEAK- 176
Cdd:PRK03918 208 EINEISSELPELREELEklEKEVKELEELKEEIEELEKELESLEGSkrkleEKIRELEERIEELKKEIEELEEKVKELKe 287

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693900361 177 -----DQYDTAIKARSESQKEVNELLQRkhswtpsdLERFTQLYKDDAENLQLQEQAKERLGELEAKEEEISTNLyrAIL 251
Cdd:PRK03918 288 lkekaEEYIKLSEFYEEYLDELREIEKR--------LSRLEEEINGIEERIKELEEKEERLEELKKKLKELEKRL--EEL 357


                 ....*.
gi 693900361 252 TRYHEE 257
Cdd:PRK03918 358 EERHEL 363
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
68-241 6.98e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 38.74  E-value: 6.98e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693900361   68 LKIQLDKAQKSIQDANEKLARMEN--DSHDSNLNFNAEGKIKDLPSERERHRKKWARKMELyLDSLQETIFTATRALNDV 145
Cdd:COG4913   307 LEAELERLEARLDALREELDELEAqiRGNGGDRLEQLEREIERLERELEERERRRARLEAL-LAALGLPLPASAEEFAAL 385

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693900361  146 tgyssIQTLRNTIELLEKELKDTKKLVNEAKDQYDTAIKARSESQKEVNELLQRKHSWtPSDLERF-TQLykddAENLQL 224
Cdd:COG4913   386 -----RAEAAALLEALEEELEALEEALAEAEAALRDLRRELRELEAEIASLERRKSNI-PARLLALrDAL----AEALGL 455

                         170
                  ....*....|....*...
gi 693900361  225 QEQAKERLGEL-EAKEEE 241
Cdd:COG4913   456 DEAELPFVGELiEVRPEE 473
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
56-257 8.81e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 38.36  E-value: 8.81e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693900361   56 DTLGKLRGYSMNLkIQLDKAQKSIQDANEKLARMENDSHDsnlnfnaegkikdlpsererhrkkwarkmelyLDSLQETI 135
Cdd:COG4913   648 EALQRLAEYSWDE-IDVASAEREIAELEAELERLDASSDD--------------------------------LAALEEQL 694

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693900361  136 FTATRALNDVTgySSIQTLRNTIELLEKELKDTKKLVNEAKDQYDTAIKarsESQKEVNELLQrkhswtpsdlERFTQLY 215
Cdd:COG4913   695 EELEAELEELE--EELDELKGEIGRLEKELEQAEEELDELQDRLEAAED---LARLELRALLE----------ERFAAAL 759

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 693900361  216 KDDAENlQLQEQAKERLGELEAKEEEISTNLYRAIlTRYHEE 257
Cdd:COG4913   760 GDAVER-ELRENLEERIDALRARLNRAEEELERAM-RAFNRE 799
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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