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Conserved domains on  [gi|1207588923|dbj|BAX91803|]
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signal recognition particle protein [Mycobacterium shigaense]

Protein Classification

signal recognition particle protein( domain architecture ID 11425425)

signal recognition particle protein such as SRP54, a GTPase involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane; binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes

CATH:  1.20.120.140
Gene Ontology:  GO:0005525|GO:0006614|GO:0048500|GO:0003924
PubMed:  28524878|17507650
SCOP:  4000906

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ffh COG0541
Signal recognition particle GTPase [Intracellular trafficking, secretion, and vesicular ...
 1-433 0e+00

Signal recognition particle GTPase [Intracellular trafficking, secretion, and vesicular transport];


:

Pssm-ID: 440307 [Multi-domain]  Cd Length: 423  Bit Score: 720.27  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207588923   1 MFESLSDRLTGALAGLRGKGRLTDADIDATTREIRLALLEADVSLPVVRAFVGRIKERARGAEVSGALNPAQQVVKIVNE 80
Cdd:COG0541     1 MFENLSERLQGAFKKLRGKGRLTEENIKEALREVRRALLEADVNLKVVKDFIERVKERALGEEVLKSLTPGQQVIKIVHD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207588923  81 ELIGILGGQTRQLVFAKTPPTVIMLAGLQGSGKTTLAGKLAFWLRNQGHTPLLVACDLQRPAAVNQLQVVGQRAGVPVFA 160
Cdd:COG0541    81 ELVELLGGENEELNLAKKPPTVIMMVGLQGSGKTTTAAKLAKYLKKKGKKPLLVAADVYRPAAIEQLKTLGEQIGVPVFP 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207588923 161 PhpgappsgpdtGPEGDPVAVAAAGLAEAQAKHHDVVIVDTAGRLGIDDELMSQAAAIRDAINPDEVIFVLDAMIGQDAV 240
Cdd:COG0541   161 E-----------EDGKDPVDIAKRALEYAKKNGYDVVIVDTAGRLHIDEELMDELKAIKAAVNPDETLLVVDAMTGQDAV 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207588923 241 TTAEAFREGVGFTGVVLTKLDGDARGGAALSVREVTGVPILFASTGEKLEDFDVFHPDRMSSRILGMGDVLSLIEQAEQV 320
Cdd:COG0541   230 NVAKAFNEALGLTGVILTKLDGDARGGAALSIRAVTGKPIKFIGTGEKLDDLEPFHPDRMASRILGMGDVLSLIEKAQEA 309

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207588923 321 FDAEQAEAAAAKIGSGELTLEDFLEQMLAIRKMGPIGNLLGMLPGAGQMR-DALAEVDDRQLDRLQAIIRGMTPQERADP 399
Cdd:COG0541   310 IDEEEAEKLAKKLKKGKFDLEDFLEQLQQMKKMGPLKKLLGMLPGMGKLKqLKDLDIDEKELKRIEAIINSMTPEERRNP 389

                         410       420       430
                  ....*....|....*....|....*....|....
gi 1207588923 400 KIINASRRLRIANGSGVTVAEVNQLVDRFFEARK 433
Cdd:COG0541   390 DIINGSRKRRIAKGSGTTVQDVNRLLKQFEQMKK 423
 
Name Accession Description Interval E-value
Ffh COG0541
Signal recognition particle GTPase [Intracellular trafficking, secretion, and vesicular ...
 1-433 0e+00

Signal recognition particle GTPase [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440307 [Multi-domain]  Cd Length: 423  Bit Score: 720.27  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207588923   1 MFESLSDRLTGALAGLRGKGRLTDADIDATTREIRLALLEADVSLPVVRAFVGRIKERARGAEVSGALNPAQQVVKIVNE 80
Cdd:COG0541     1 MFENLSERLQGAFKKLRGKGRLTEENIKEALREVRRALLEADVNLKVVKDFIERVKERALGEEVLKSLTPGQQVIKIVHD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207588923  81 ELIGILGGQTRQLVFAKTPPTVIMLAGLQGSGKTTLAGKLAFWLRNQGHTPLLVACDLQRPAAVNQLQVVGQRAGVPVFA 160
Cdd:COG0541    81 ELVELLGGENEELNLAKKPPTVIMMVGLQGSGKTTTAAKLAKYLKKKGKKPLLVAADVYRPAAIEQLKTLGEQIGVPVFP 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207588923 161 PhpgappsgpdtGPEGDPVAVAAAGLAEAQAKHHDVVIVDTAGRLGIDDELMSQAAAIRDAINPDEVIFVLDAMIGQDAV 240
Cdd:COG0541   161 E-----------EDGKDPVDIAKRALEYAKKNGYDVVIVDTAGRLHIDEELMDELKAIKAAVNPDETLLVVDAMTGQDAV 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207588923 241 TTAEAFREGVGFTGVVLTKLDGDARGGAALSVREVTGVPILFASTGEKLEDFDVFHPDRMSSRILGMGDVLSLIEQAEQV 320
Cdd:COG0541   230 NVAKAFNEALGLTGVILTKLDGDARGGAALSIRAVTGKPIKFIGTGEKLDDLEPFHPDRMASRILGMGDVLSLIEKAQEA 309

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207588923 321 FDAEQAEAAAAKIGSGELTLEDFLEQMLAIRKMGPIGNLLGMLPGAGQMR-DALAEVDDRQLDRLQAIIRGMTPQERADP 399
Cdd:COG0541   310 IDEEEAEKLAKKLKKGKFDLEDFLEQLQQMKKMGPLKKLLGMLPGMGKLKqLKDLDIDEKELKRIEAIINSMTPEERRNP 389

                         410       420       430
                  ....*....|....*....|....*....|....
gi 1207588923 400 KIINASRRLRIANGSGVTVAEVNQLVDRFFEARK 433
Cdd:COG0541   390 DIINGSRKRRIAKGSGTTVQDVNRLLKQFEQMKK 423
ffh TIGR00959
signal recognition particle protein; This model represents Ffh (Fifty-Four Homolog), the ...
 2-437 0e+00

signal recognition particle protein; This model represents Ffh (Fifty-Four Homolog), the protein component that forms the bacterial (and organellar) signal recognition particle together with a 4.5S RNA. Ffh is a GTPase homologous to eukaryotic SRP54 and also to the GTPase FtsY (TIGR00064) that is the receptor for the signal recognition particle. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 273364 [Multi-domain]  Cd Length: 428  Bit Score: 633.56  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207588923   2 FESLSDRLTGALAGLRGKGRLTDADIDATTREIRLALLEADVSLPVVRAFVGRIKERARGAEVSGALNPAQQVVKIVNEE 81
Cdd:TIGR00959   1 FESLSERLQRIFKKLSGRGTITEKNIKEALREIRLALLEADVNLQVVKDFIKKVKEKALGQEVLKSLSPGQQFIKIVHEE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207588923  82 LIGILGGQTRQLVFAKTPPTVIMLAGLQGSGKTTLAGKLAFWLRN-QGHTPLLVACDLQRPAAVNQLQVVGQRAGVPVFA 160
Cdd:TIGR00959  81 LVAILGGENAELNLAKKPPTVILMVGLQGSGKTTTCGKLAYYLKKkQGKKVLLVACDLYRPAAIEQLKVLGQQVGVPVFA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207588923 161 PHPGAPPsgpdtgpegdpVAVAAAGLAEAQAKHHDVVIVDTAGRLGIDDELMSQAAAIRDAINPDEVIFVLDAMIGQDAV 240
Cdd:TIGR00959 161 LGKGQSP-----------VEIARRALEYAKENGFDVVIVDTAGRLQIDEELMEELAAIKEILNPDEILLVVDAMTGQDAV 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207588923 241 TTAEAFREGVGFTGVVLTKLDGDARGGAALSVREVTGVPILFASTGEKLEDFDVFHPDRMSSRILGMGDVLSLIEQAEQV 320
Cdd:TIGR00959 230 NTAKTFNERLGLTGVVLTKLDGDARGGAALSVRSVTGKPIKFIGVGEKIDDLEPFHPERMASRILGMGDILSLVEKAQEV 309

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207588923 321 FDAEQAEAAAAKIGSGELTLEDFLEQMLAIRKMGPIGNLLGMLPGAGQMRDAL--AEVDDRQLDRLQAIIRGMTPQERAD 398
Cdd:TIGR00959 310 VDEEEAKKLAEKMKKGQFDLEDFLEQLRQIKKMGPLSSLLKMIPGMGGVKPSLsdADLDEKQFKRIEAIISSMTPEERRN 389

                         410       420       430
                  ....*....|....*....|....*....|....*....
gi 1207588923 399 PKIINASRRLRIANGSGVTVAEVNQLVDRFFEARKMMSS 437
Cdd:TIGR00959 390 PKILNPSRRKRIAAGSGTTVQDVNKLIKRFEQMKKMMKK 428
PRK00771 PRK00771
signal recognition particle protein Srp54; Provisional
 5-443 5.02e-155

signal recognition particle protein Srp54; Provisional


Pssm-ID: 179118 [Multi-domain]  Cd Length: 437  Bit Score: 449.27  E-value: 5.02e-155
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207588923   5 LSDRLTGALAGLRGKGRLTDADIDATTREIRLALLEADVSLPVVRAFVGRIKERARGAEVSGALNPAQQVVKIVNEELIG 84
Cdd:PRK00771    1 LGESLRDALKKLAGKSRIDEKTVKEVVKDIQRALLQADVNVKLVKELSKSIKERALEEEPPKGLTPREHVIKIVYEELVK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207588923  85 ILGGQTRQLVFAKTPpTVIMLAGLQGSGKTTLAGKLAFWLRNQGHTPLLVACDLQRPAAVNQLQVVGQRAGVPVFAphpg 164
Cdd:PRK00771   81 LLGEETEPLVLPLKP-QTIMLVGLQGSGKTTTAAKLARYFKKKGLKVGLVAADTYRPAAYDQLKQLAEKIGVPFYG---- 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207588923 165 appsGPDtgpEGDPVAVAAAGLAEAqaKHHDVVIVDTAGRLGIDDELMSQAAAIRDAINPDEVIFVLDAMIGQDAVTTAE 244
Cdd:PRK00771  156 ----DPD---NKDAVEIAKEGLEKF--KKADVIIVDTAGRHALEEDLIEEMKEIKEAVKPDEVLLVIDATIGQQAKNQAK 226

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207588923 245 AFREGVGFTGVVLTKLDGDARGGAALSVREVTGVPILFASTGEKLEDFDVFHPDRMSSRILGMGDVLSLIEQAEQVFDAE 324
Cdd:PRK00771  227 AFHEAVGIGGIIITKLDGTAKGGGALSAVAETGAPIKFIGTGEKIDDLERFDPDRFISRLLGMGDLESLLEKVEEALDEE 306

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207588923 325 QAEAAAAKIGSGELTLEDFLEQMLAIRKMGPIGNLLGMLPGAG-QMRDALAEVDDRQLDRLQAIIRGMTPQERADPKIIN 403
Cdd:PRK00771  307 EEEKDVEKMMKGKFTLKDMYKQLEAMNKMGPLKQILQMLPGLGgKLPDEALEVTEEKLKKYKAIMDSMTEEELENPEIIN 386

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|
gi 1207588923 404 ASRRLRIANGSGVTVAEVNQLVDRFFEARKMMSSMLGGMG 443
Cdd:PRK00771  387 ASRIRRIARGSGTTVEDVRELLKYYKMMKKAMKQLKKGKG 426
SRP_G cd18539
GTPase domain of signal recognition particle protein; The signal recognition particle (SRP) ...
 101-304 3.74e-101

GTPase domain of signal recognition particle protein; The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal signal sequences of newly synthesized polypeptides at the ribosome. The SRP-polypeptide complex is then targeted to the membrane by an interaction between SRP and its cognated receptor (SR). In mammals, SRP consists of six protein subunits and a 7SL RNA. One of these subunits is a 54 kd protein (SRP54), which is a GTP-binding protein that interacts with the signal sequence when it emerges from the ribosome. SRP54 is a multidomain protein that consists of an N-terminal domain, followed by a central G (GTPase) domain and a C-terminal M domain.


Pssm-ID: 349786  Cd Length: 193  Bit Score: 302.60  E-value: 3.74e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207588923 101 TVIMLAGLQGSGKTTLAGKLAFWLRNQGHTPLLVACDLQRPAAVNQLQVVGQRAGVPVFAPHPGAppsgpdtgpegDPVA 180
Cdd:cd18539     1 TVILLVGLQGSGKTTTAAKLALYLKKKGKKVLLVAADVYRPAAIEQLQTLGEQVGVPVFESGDGQ-----------SPVD 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207588923 181 VAAAGLAEAQAKHHDVVIVDTAGRLGIDDELMSQAAAIRDAINPDEVIFVLDAMIGQDAVTTAEAFREGVGFTGVVLTKL 260
Cdd:cd18539    70 IAKRALEKAKEEGFDVVIVDTAGRLHIDEELMDELKEIKEVLNPDEVLLVVDAMTGQDAVNVAKAFNERLGLTGVVLTKL 149

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1207588923 261 DGDARGGAALSVREVTGVPILFASTGEKLEDFDVFHPDRMSSRI 304
Cdd:cd18539   150 DGDARGGAALSIRHVTGKPIKFIGVGEKIEDLEPFHPDRMASRI 193
SRP54 smart00962
SRP54-type protein, GTPase domain; This entry represents the GTPase domain of the 54 kDa SRP54 ...
 100-306 4.28e-90

SRP54-type protein, GTPase domain; This entry represents the GTPase domain of the 54 kDa SRP54 component, a GTP-binding protein that interacts with the signal sequence when it emerges from the ribosome. SRP54 of the signal recognition particle has a three-domain structure: an N-terminal helical bundle domain, a GTPase domain, and the M-domain that binds the 7s RNA and also binds the signal sequence. The extreme C-terminal region is glycine-rich and lower in complexity and poorly conserved between species. The GTPase domain is evolutionary related to P-loop NTPase domains found in a variety of other proteins.


Pssm-ID: 214940  Cd Length: 197  Bit Score: 274.29  E-value: 4.28e-90
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207588923  100 PTVIMLAGLQGSGKTTLAGKLAFWLRNQG-HTPLLVACDLQRPAAVNQLQVVGQRAGVPVFAPHPGAppsgpdtgpegDP 178
Cdd:smart00962   1 PGVILLVGPNGVGKTTTIAKLAARLKLKGgKKVLLVAADTFRAAAVEQLKTYAEILGVVPVAGGEGA-----------DP 69

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207588923  179 VAVAAAGLAEAQAKHHDVVIVDTAGRLGIDDELMSQAAAIRDAINPDEVIFVLDAMIGQDAVTTAEAFREGVGFTGVVLT 258
Cdd:smart00962  70 VAVAKDAVELAKARGYDVVLIDTAGRLHNDENLMEELKKIKRVIKPDEVLLVSDATTGQDAVEQAKAFNEALGLTGIILT 149

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*...
gi 1207588923  259 KLDGDARGGAALSVREVTGVPILFASTGEKLEDFDVFHPDRMSSRILG 306
Cdd:smart00962 150 KLDGTAKGGAALSIAAETGLPIKFIGTGEKVPDLEPFDPERFVSRLLG 197
SRP54 pfam00448
SRP54-type protein, GTPase domain; This family includes relatives of the G-domain of the SRP54 ...
 101-304 5.78e-88

SRP54-type protein, GTPase domain; This family includes relatives of the G-domain of the SRP54 family of proteins.


Pssm-ID: 459814 [Multi-domain]  Cd Length: 193  Bit Score: 268.64  E-value: 5.78e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207588923 101 TVIMLAGLQGSGKTTLAGKLAFWLRNQGHTPLLVACDLQRPAAVNQLQVVGQRAGVPVFAPHPGAppsgpdtgpegDPVA 180
Cdd:pfam00448   1 NVILLVGLQGSGKTTTIAKLAAYLKKKGKKVLLVAADTFRAAAIEQLKQLAEKLGVPVFGSKTGA-----------DPAA 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207588923 181 VAAAGLAEAQAKHHDVVIVDTAGRLGIDDELMSQAAAIRDAINPDEVIFVLDAMIGQDAVTTAEAFREGVGFTGVVLTKL 260
Cdd:pfam00448  70 VAFDAVEKAKAENYDVVLVDTAGRLQNDKNLMDELKKIKRVVAPDEVLLVLDATTGQNAVNQAKAFNEAVGITGVILTKL 149

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1207588923 261 DGDARGGAALSVREVTGVPILFASTGEKLEDFDVFHPDRMSSRI 304
Cdd:pfam00448 150 DGDAKGGAALSIVAETGKPIKFIGVGEKIDDLEPFDPERFVSRL 193
 
Name Accession Description Interval E-value
Ffh COG0541
Signal recognition particle GTPase [Intracellular trafficking, secretion, and vesicular ...
 1-433 0e+00

Signal recognition particle GTPase [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440307 [Multi-domain]  Cd Length: 423  Bit Score: 720.27  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207588923   1 MFESLSDRLTGALAGLRGKGRLTDADIDATTREIRLALLEADVSLPVVRAFVGRIKERARGAEVSGALNPAQQVVKIVNE 80
Cdd:COG0541     1 MFENLSERLQGAFKKLRGKGRLTEENIKEALREVRRALLEADVNLKVVKDFIERVKERALGEEVLKSLTPGQQVIKIVHD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207588923  81 ELIGILGGQTRQLVFAKTPPTVIMLAGLQGSGKTTLAGKLAFWLRNQGHTPLLVACDLQRPAAVNQLQVVGQRAGVPVFA 160
Cdd:COG0541    81 ELVELLGGENEELNLAKKPPTVIMMVGLQGSGKTTTAAKLAKYLKKKGKKPLLVAADVYRPAAIEQLKTLGEQIGVPVFP 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207588923 161 PhpgappsgpdtGPEGDPVAVAAAGLAEAQAKHHDVVIVDTAGRLGIDDELMSQAAAIRDAINPDEVIFVLDAMIGQDAV 240
Cdd:COG0541   161 E-----------EDGKDPVDIAKRALEYAKKNGYDVVIVDTAGRLHIDEELMDELKAIKAAVNPDETLLVVDAMTGQDAV 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207588923 241 TTAEAFREGVGFTGVVLTKLDGDARGGAALSVREVTGVPILFASTGEKLEDFDVFHPDRMSSRILGMGDVLSLIEQAEQV 320
Cdd:COG0541   230 NVAKAFNEALGLTGVILTKLDGDARGGAALSIRAVTGKPIKFIGTGEKLDDLEPFHPDRMASRILGMGDVLSLIEKAQEA 309

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207588923 321 FDAEQAEAAAAKIGSGELTLEDFLEQMLAIRKMGPIGNLLGMLPGAGQMR-DALAEVDDRQLDRLQAIIRGMTPQERADP 399
Cdd:COG0541   310 IDEEEAEKLAKKLKKGKFDLEDFLEQLQQMKKMGPLKKLLGMLPGMGKLKqLKDLDIDEKELKRIEAIINSMTPEERRNP 389

                         410       420       430
                  ....*....|....*....|....*....|....
gi 1207588923 400 KIINASRRLRIANGSGVTVAEVNQLVDRFFEARK 433
Cdd:COG0541   390 DIINGSRKRRIAKGSGTTVQDVNRLLKQFEQMKK 423
ffh TIGR00959
signal recognition particle protein; This model represents Ffh (Fifty-Four Homolog), the ...
 2-437 0e+00

signal recognition particle protein; This model represents Ffh (Fifty-Four Homolog), the protein component that forms the bacterial (and organellar) signal recognition particle together with a 4.5S RNA. Ffh is a GTPase homologous to eukaryotic SRP54 and also to the GTPase FtsY (TIGR00064) that is the receptor for the signal recognition particle. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 273364 [Multi-domain]  Cd Length: 428  Bit Score: 633.56  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207588923   2 FESLSDRLTGALAGLRGKGRLTDADIDATTREIRLALLEADVSLPVVRAFVGRIKERARGAEVSGALNPAQQVVKIVNEE 81
Cdd:TIGR00959   1 FESLSERLQRIFKKLSGRGTITEKNIKEALREIRLALLEADVNLQVVKDFIKKVKEKALGQEVLKSLSPGQQFIKIVHEE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207588923  82 LIGILGGQTRQLVFAKTPPTVIMLAGLQGSGKTTLAGKLAFWLRN-QGHTPLLVACDLQRPAAVNQLQVVGQRAGVPVFA 160
Cdd:TIGR00959  81 LVAILGGENAELNLAKKPPTVILMVGLQGSGKTTTCGKLAYYLKKkQGKKVLLVACDLYRPAAIEQLKVLGQQVGVPVFA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207588923 161 PHPGAPPsgpdtgpegdpVAVAAAGLAEAQAKHHDVVIVDTAGRLGIDDELMSQAAAIRDAINPDEVIFVLDAMIGQDAV 240
Cdd:TIGR00959 161 LGKGQSP-----------VEIARRALEYAKENGFDVVIVDTAGRLQIDEELMEELAAIKEILNPDEILLVVDAMTGQDAV 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207588923 241 TTAEAFREGVGFTGVVLTKLDGDARGGAALSVREVTGVPILFASTGEKLEDFDVFHPDRMSSRILGMGDVLSLIEQAEQV 320
Cdd:TIGR00959 230 NTAKTFNERLGLTGVVLTKLDGDARGGAALSVRSVTGKPIKFIGVGEKIDDLEPFHPERMASRILGMGDILSLVEKAQEV 309

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207588923 321 FDAEQAEAAAAKIGSGELTLEDFLEQMLAIRKMGPIGNLLGMLPGAGQMRDAL--AEVDDRQLDRLQAIIRGMTPQERAD 398
Cdd:TIGR00959 310 VDEEEAKKLAEKMKKGQFDLEDFLEQLRQIKKMGPLSSLLKMIPGMGGVKPSLsdADLDEKQFKRIEAIISSMTPEERRN 389

                         410       420       430
                  ....*....|....*....|....*....|....*....
gi 1207588923 399 PKIINASRRLRIANGSGVTVAEVNQLVDRFFEARKMMSS 437
Cdd:TIGR00959 390 PKILNPSRRKRIAAGSGTTVQDVNKLIKRFEQMKKMMKK 428
PRK00771 PRK00771
signal recognition particle protein Srp54; Provisional
 5-443 5.02e-155

signal recognition particle protein Srp54; Provisional


Pssm-ID: 179118 [Multi-domain]  Cd Length: 437  Bit Score: 449.27  E-value: 5.02e-155
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207588923   5 LSDRLTGALAGLRGKGRLTDADIDATTREIRLALLEADVSLPVVRAFVGRIKERARGAEVSGALNPAQQVVKIVNEELIG 84
Cdd:PRK00771    1 LGESLRDALKKLAGKSRIDEKTVKEVVKDIQRALLQADVNVKLVKELSKSIKERALEEEPPKGLTPREHVIKIVYEELVK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207588923  85 ILGGQTRQLVFAKTPpTVIMLAGLQGSGKTTLAGKLAFWLRNQGHTPLLVACDLQRPAAVNQLQVVGQRAGVPVFAphpg 164
Cdd:PRK00771   81 LLGEETEPLVLPLKP-QTIMLVGLQGSGKTTTAAKLARYFKKKGLKVGLVAADTYRPAAYDQLKQLAEKIGVPFYG---- 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207588923 165 appsGPDtgpEGDPVAVAAAGLAEAqaKHHDVVIVDTAGRLGIDDELMSQAAAIRDAINPDEVIFVLDAMIGQDAVTTAE 244
Cdd:PRK00771  156 ----DPD---NKDAVEIAKEGLEKF--KKADVIIVDTAGRHALEEDLIEEMKEIKEAVKPDEVLLVIDATIGQQAKNQAK 226

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207588923 245 AFREGVGFTGVVLTKLDGDARGGAALSVREVTGVPILFASTGEKLEDFDVFHPDRMSSRILGMGDVLSLIEQAEQVFDAE 324
Cdd:PRK00771  227 AFHEAVGIGGIIITKLDGTAKGGGALSAVAETGAPIKFIGTGEKIDDLERFDPDRFISRLLGMGDLESLLEKVEEALDEE 306

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207588923 325 QAEAAAAKIGSGELTLEDFLEQMLAIRKMGPIGNLLGMLPGAG-QMRDALAEVDDRQLDRLQAIIRGMTPQERADPKIIN 403
Cdd:PRK00771  307 EEEKDVEKMMKGKFTLKDMYKQLEAMNKMGPLKQILQMLPGLGgKLPDEALEVTEEKLKKYKAIMDSMTEEELENPEIIN 386

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|
gi 1207588923 404 ASRRLRIANGSGVTVAEVNQLVDRFFEARKMMSSMLGGMG 443
Cdd:PRK00771  387 ASRIRRIARGSGTTVEDVRELLKYYKMMKKAMKQLKKGKG 426
SRP_G cd18539
GTPase domain of signal recognition particle protein; The signal recognition particle (SRP) ...
 101-304 3.74e-101

GTPase domain of signal recognition particle protein; The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal signal sequences of newly synthesized polypeptides at the ribosome. The SRP-polypeptide complex is then targeted to the membrane by an interaction between SRP and its cognated receptor (SR). In mammals, SRP consists of six protein subunits and a 7SL RNA. One of these subunits is a 54 kd protein (SRP54), which is a GTP-binding protein that interacts with the signal sequence when it emerges from the ribosome. SRP54 is a multidomain protein that consists of an N-terminal domain, followed by a central G (GTPase) domain and a C-terminal M domain.


Pssm-ID: 349786  Cd Length: 193  Bit Score: 302.60  E-value: 3.74e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207588923 101 TVIMLAGLQGSGKTTLAGKLAFWLRNQGHTPLLVACDLQRPAAVNQLQVVGQRAGVPVFAPHPGAppsgpdtgpegDPVA 180
Cdd:cd18539     1 TVILLVGLQGSGKTTTAAKLALYLKKKGKKVLLVAADVYRPAAIEQLQTLGEQVGVPVFESGDGQ-----------SPVD 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207588923 181 VAAAGLAEAQAKHHDVVIVDTAGRLGIDDELMSQAAAIRDAINPDEVIFVLDAMIGQDAVTTAEAFREGVGFTGVVLTKL 260
Cdd:cd18539    70 IAKRALEKAKEEGFDVVIVDTAGRLHIDEELMDELKEIKEVLNPDEVLLVVDAMTGQDAVNVAKAFNERLGLTGVVLTKL 149

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1207588923 261 DGDARGGAALSVREVTGVPILFASTGEKLEDFDVFHPDRMSSRI 304
Cdd:cd18539   150 DGDARGGAALSIRHVTGKPIKFIGVGEKIEDLEPFHPDRMASRI 193
SRP54_euk TIGR01425
signal recognition particle protein SRP54; This model represents examples from the eukaryotic ...
 5-438 8.41e-92

signal recognition particle protein SRP54; This model represents examples from the eukaryotic cytosol of the signal recognition particle protein component, SRP54. This GTP-binding protein is a component of the eukaryotic signal recognition particle, along with several other protein subunits and a 7S RNA. Some species, including Arabidopsis, have several closely related forms. The extreme C-terminal region is glycine-rich and lower in complexity, poorly conserved between species, and excluded from this model.


Pssm-ID: 273615 [Multi-domain]  Cd Length: 428  Bit Score: 287.12  E-value: 8.41e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207588923   5 LSDRLTGALAGLRGKGRLTDADIDATTREIRLALLEADVSLPVVRAFVGRIKERARGAEVSGALNPAQQVVKIVNEELIG 84
Cdd:TIGR01425   5 LGSSLVTALRSMSSATVIDEEVINTMLKEICTALLESDVNPKLVRQMRNNIKKKINLEDIASGINKRKLIQDAVFEELCN 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207588923  85 ILGGQTRQLVFAKTPPTVIMLAGLQGSGKTTLAGKLAFWLRNQGHTPLLVACDLQRPAAVNQLQVVGQRAGVPVFAPHPg 164
Cdd:TIGR01425  85 LVDPGVEAFTPKKGKTCVIMFVGLQGAGKTTTCTKLAYYYKRRGFKPALVCADTFRAGAFDQLKQNATKAGIPFYGSYE- 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207588923 165 appsgpdtgpEGDPVAVAAAGLAEAQAKHHDVVIVDTAGRLGIDDELMSQAAAIRDAINPDEVIFVLDAMIGQDAVTTAE 244
Cdd:TIGR01425 164 ----------ESDPVKIASEGVEKFRKEKFDIIIVDTSGRHKQEKELFEEMQQVREAIKPDSIIFVMDGSIGQAAFGQAK 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207588923 245 AFREGVGFTGVVLTKLDGDARGGAALSVREVTGVPILFASTGEKLEDFDVFHPDRMSSRILGMGDVLSLIEQAEQVFDAE 324
Cdd:TIGR01425 234 AFKDSVEVGSVIITKLDGHAKGGGALSAVAATKSPIIFIGTGEHVDEFEIFDAEPFVSKLLGMGDLKGLIDKVQDLALND 313

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207588923 325 QAEAAAAKIGSGELTLEDFLEQMLAIRKMGPIGNLLGMLPGAGQ--MRDALAEVDDRQLDRLQAIIRGMTPQE-RADPKI 401
Cdd:TIGR01425 314 EEKTLIEHLKEGTFTLRDWYEQFQNLLKMGPLGNIMSMIPGLSHpmMSKGNEEETSAKIKVFMTIMDSMTDRElDSTAKT 393

                         410       420       430
                  ....*....|....*....|....*....|....*....
gi 1207588923 402 I--NASRRLRIANGSGVTVAEVNQLvdrfFEARKMMSSM 438
Cdd:TIGR01425 394 MlkDPSRIRRVARGSGRDIREVNEL----LEQYKLFAQM 428
SRP54 smart00962
SRP54-type protein, GTPase domain; This entry represents the GTPase domain of the 54 kDa SRP54 ...
 100-306 4.28e-90

SRP54-type protein, GTPase domain; This entry represents the GTPase domain of the 54 kDa SRP54 component, a GTP-binding protein that interacts with the signal sequence when it emerges from the ribosome. SRP54 of the signal recognition particle has a three-domain structure: an N-terminal helical bundle domain, a GTPase domain, and the M-domain that binds the 7s RNA and also binds the signal sequence. The extreme C-terminal region is glycine-rich and lower in complexity and poorly conserved between species. The GTPase domain is evolutionary related to P-loop NTPase domains found in a variety of other proteins.


Pssm-ID: 214940  Cd Length: 197  Bit Score: 274.29  E-value: 4.28e-90
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207588923  100 PTVIMLAGLQGSGKTTLAGKLAFWLRNQG-HTPLLVACDLQRPAAVNQLQVVGQRAGVPVFAPHPGAppsgpdtgpegDP 178
Cdd:smart00962   1 PGVILLVGPNGVGKTTTIAKLAARLKLKGgKKVLLVAADTFRAAAVEQLKTYAEILGVVPVAGGEGA-----------DP 69

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207588923  179 VAVAAAGLAEAQAKHHDVVIVDTAGRLGIDDELMSQAAAIRDAINPDEVIFVLDAMIGQDAVTTAEAFREGVGFTGVVLT 258
Cdd:smart00962  70 VAVAKDAVELAKARGYDVVLIDTAGRLHNDENLMEELKKIKRVIKPDEVLLVSDATTGQDAVEQAKAFNEALGLTGIILT 149

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*...
gi 1207588923  259 KLDGDARGGAALSVREVTGVPILFASTGEKLEDFDVFHPDRMSSRILG 306
Cdd:smart00962 150 KLDGTAKGGAALSIAAETGLPIKFIGTGEKVPDLEPFDPERFVSRLLG 197
SRP54 pfam00448
SRP54-type protein, GTPase domain; This family includes relatives of the G-domain of the SRP54 ...
 101-304 5.78e-88

SRP54-type protein, GTPase domain; This family includes relatives of the G-domain of the SRP54 family of proteins.


Pssm-ID: 459814 [Multi-domain]  Cd Length: 193  Bit Score: 268.64  E-value: 5.78e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207588923 101 TVIMLAGLQGSGKTTLAGKLAFWLRNQGHTPLLVACDLQRPAAVNQLQVVGQRAGVPVFAPHPGAppsgpdtgpegDPVA 180
Cdd:pfam00448   1 NVILLVGLQGSGKTTTIAKLAAYLKKKGKKVLLVAADTFRAAAIEQLKQLAEKLGVPVFGSKTGA-----------DPAA 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207588923 181 VAAAGLAEAQAKHHDVVIVDTAGRLGIDDELMSQAAAIRDAINPDEVIFVLDAMIGQDAVTTAEAFREGVGFTGVVLTKL 260
Cdd:pfam00448  70 VAFDAVEKAKAENYDVVLVDTAGRLQNDKNLMDELKKIKRVVAPDEVLLVLDATTGQNAVNQAKAFNEAVGITGVILTKL 149

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1207588923 261 DGDARGGAALSVREVTGVPILFASTGEKLEDFDVFHPDRMSSRI 304
Cdd:pfam00448 150 DGDAKGGAALSIVAETGKPIKFIGVGEKIDDLEPFDPERFVSRL 193
FtsY COG0552
Signal recognition particle GTPase FtsY [Intracellular trafficking, secretion, and vesicular ...
 1-306 1.46e-78

Signal recognition particle GTPase FtsY [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440318 [Multi-domain]  Cd Length: 303  Bit Score: 248.40  E-value: 1.46e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207588923   1 MFESLSDRL-------TGALAGL-RGKGRLTDADIDattrEIRLALLEADVSLPVVRAFVGRIKERARGAEVSgalnPAQ 72
Cdd:COG0552     1 FFERLKEGLsktrsglGEKLKSLfSGKKKIDEDLLE----ELEELLIEADVGVETTEEIIEELRERVKRKKLK----DPE 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207588923  73 QVVKIVNEELIGILGGQTRQLVFAKTPPTVIMLAGLQGSGKTTLAGKLAFWLRNQGHTPLLVACDLQRPAAVNQLQVVGQ 152
Cdd:COG0552    73 ELKEALKEELLEILDPVDKPLAIEEKKPFVILVVGVNGVGKTTTIGKLAHRLKAEGKSVLLAAGDTFRAAAIEQLEVWGE 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207588923 153 RAGVPVFAPHPGAPPSGP--DTgpegdpvavaaagLAEAQAKHHDVVIVDTAGRLGIDDELMSQAAAIRDAIN------P 224
Cdd:COG0552   153 RVGVPVIAQKEGADPAAVafDA-------------IQAAKARGADVVIIDTAGRLHNKKNLMEELKKIKRVIKkldpdaP 219

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207588923 225 DEVIFVLDAMIGQDAVTTAEAFREGVGFTGVVLTKLDGDARGGAALSVREVTGVPILFASTGEKLEDFDVFHPDRMSSRI 304
Cdd:COG0552   220 HEVLLVLDATTGQNALSQAKVFNEAVGVTGIVLTKLDGTAKGGVVLAIADELGIPIKFIGVGEGIDDLRPFDAEEFVDAL 299


                  ..
gi 1207588923 305 LG 306
Cdd:COG0552   300 FG 301
SRP_G_like cd03115
GTPase domain similar to the signal recognition particle subunit 54; The signal recognition ...
 102-304 6.69e-70

GTPase domain similar to the signal recognition particle subunit 54; The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal signal sequences of newly synthesized polypeptides at the ribosome. The SRP-polypeptide complex is then targeted to the membrane by an interaction between SRP and its cognate receptor (SR). In mammals, SRP consists of six protein subunits and a 7SL RNA. One of these subunits is a 54 kd protein (SRP54), which is a GTP-binding protein that interacts with the signal sequence when it emerges from the ribosome. SRP54 is a multidomain protein that consists of an N-terminal domain, followed by a central G (GTPase) domain and a C-terminal M domain.


Pssm-ID: 349769 [Multi-domain]  Cd Length: 193  Bit Score: 222.25  E-value: 6.69e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207588923 102 VIMLAGLQGSGKTTLAGKLAFWLRNQGHTPLLVACDLQRPAAVNQLQVVGQRAGVPVFAPHPGAppsgpdtgpegDPVAV 181
Cdd:cd03115     2 VILLVGLQGSGKTTTLAKLARYYQEKGKKVLLIAADTFRAAAVEQLKTLAEKLGVPVFESYTGT-----------DPASI 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207588923 182 AAAGLAEAQAKHHDVVIVDTAGRLGIDDELMSQAAAIRDAINPDEVIFVLDAMIGQDAVTTAEAFREGVGFTGVVLTKLD 261
Cdd:cd03115    71 AQEAVEKAKLEGYDVLLVDTAGRLQKDEPLMEELKKVKEVESPDEVLLVLDATTGQEALSQAKAFNEAVGLTGVILTKLD 150

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1207588923 262 GDARGGAALSVREVTGVPILFASTGEKLEDFDVFHPDRMSSRI 304
Cdd:cd03115   151 GTAKGGAALSIVAETKKPIKFIGVGEKPEDLEPFDPERFVSAL 193
PRK10416 PRK10416
signal recognition particle-docking protein FtsY; Provisional
 6-306 6.18e-67

signal recognition particle-docking protein FtsY; Provisional


Pssm-ID: 236686 [Multi-domain]  Cd Length: 318  Bit Score: 218.81  E-value: 6.18e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207588923   6 SDRLTGALAGLRGKGRLTDADIDattrEIRLALLEADVSLPVVRAFVGRIKERARGAEVSGAlnpaQQVVKIVNEELIGI 85
Cdd:PRK10416   28 RENFGEGINGLFAKKKIDEDLLE----ELEELLIEADVGVETTEEIIEELRERVKRKNLKDP----EELKELLKEELAEI 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207588923  86 LGGQTRQLVFAKTPPTVIMLAGLQGSGKTTLAGKLAFWLRNQGHTPLLVACDLQRPAAVNQLQVVGQRAGVPVFAPHPGA 165
Cdd:PRK10416  100 LEPVEKPLNIEEKKPFVILVVGVNGVGKTTTIGKLAHKYKAQGKKVLLAAGDTFRAAAIEQLQVWGERVGVPVIAQKEGA 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207588923 166 PPSGP--DTGPEGdpvavaaaglaeaQAKHHDVVIVDTAGRLGIDDELMSQAAAIRDAIN------PDEVIFVLDAMIGQ 237
Cdd:PRK10416  180 DPASVafDAIQAA-------------KARGIDVLIIDTAGRLHNKTNLMEELKKIKRVIKkadpdaPHEVLLVLDATTGQ 246

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1207588923 238 DAVTTAEAFREGVGFTGVVLTKLDGDARGGAALSVREVTGVPILFASTGEKLEDFDVFHPDRMSSRILG 306
Cdd:PRK10416  247 NALSQAKAFHEAVGLTGIILTKLDGTAKGGVVFAIADELGIPIKFIGVGEGIDDLQPFDAEEFVDALLG 315
PRK14974 PRK14974
signal recognition particle-docking protein FtsY;
21-306 1.16e-66

signal recognition particle-docking protein FtsY;


Pssm-ID: 237875 [Multi-domain]  Cd Length: 336  Bit Score: 218.69  E-value: 1.16e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207588923  21 RLTDADIDATTREIRLALLEADVSLPVVRAFVGRIKERARGAEVSGALNPAQQVVKIVNEELIGILG-GQTRQLVF---A 96
Cdd:PRK14974   57 EIKEKDIEDLLEELELELLESDVALEVAEEILESLKEKLVGKKVKRGEDVEEIVKNALKEALLEVLSvGDLFDLIEeikS 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207588923  97 KTPPTVIMLAGLQGSGKTTLAGKLAFWLRNQGHTPLLVACDLQRPAAVNQLQVVGQRAGVPVFAPHPGAppsgpdtgpeg 176
Cdd:PRK14974  137 KGKPVVIVFVGVNGTGKTTTIAKLAYYLKKNGFSVVIAAGDTFRAGAIEQLEEHAERLGVKVIKHKYGA----------- 205

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207588923 177 DPVAVAAAGLAEAQAKHHDVVIVDTAGRLGIDDELMSQAAAIRDAINPDEVIFVLDAMIGQDAVTTAEAFREGVGFTGVV 256
Cdd:PRK14974  206 DPAAVAYDAIEHAKARGIDVVLIDTAGRMHTDANLMDELKKIVRVTKPDLVIFVGDALAGNDAVEQAREFNEAVGIDGVI 285

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1207588923 257 LTKLDGDARGGAALSVREVTGVPILFASTGEKLEDFDVFHPDRMSSRILG 306
Cdd:PRK14974  286 LTKVDADAKGGAALSIAYVIGKPILFLGVGQGYDDLIPFDPDWFVDKLLG 335
ftsY TIGR00064
signal recognition particle-docking protein FtsY; There is a weak division between FtsY and ...
 26-305 2.45e-65

signal recognition particle-docking protein FtsY; There is a weak division between FtsY and SRP54; both are GTPases. In E.coli, ftsY is an essential gene located in an operon with cell division genes ftsE and ftsX, but its apparent function is as the signal recognition particle docking protein. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 272883 [Multi-domain]  Cd Length: 277  Bit Score: 213.27  E-value: 2.45e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207588923  26 DIDATTREIRLALLEADVSLPVVRAFVGRIKERARGAEVSGALNPAQQVVKIVNEELIGILGGQTRQLVFAKTP-PTVIM 104
Cdd:TIGR00064   2 DDEDFFEELEEILLESDVGYEVVEKIIEALKKELKGKKVKDAEKLKEILKEYLKEILKEDLLKNTDLELIVEENkPNVIL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207588923 105 LAGLQGSGKTTLAGKLAFWLRNQGHTPLLVACDLQRPAAVNQLQVVGQRAGVPVFAPHPGAppsgpdtgpegDPVAVAAA 184
Cdd:TIGR00064  82 FVGVNGVGKTTTIAKLANKLKKQGKSVLLAAGDTFRAAAIEQLEEWAKRLGVDVIKQKEGA-----------DPAAVAFD 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207588923 185 GLAEAQAKHHDVVIVDTAGRLGIDDELMSQAAAI------RDAINPDEVIFVLDAMIGQDAVTTAEAFREGVGFTGVVLT 258
Cdd:TIGR00064 151 AIQKAKARNIDVVLIDTAGRLQNKVNLMDELKKIkrvikkVDKDAPDEVLLVLDATTGQNALEQAKVFNEAVGLTGIILT 230

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1207588923 259 KLDGDARGGAALSVREVTGVPILFASTGEKLEDFDVFHPDRMSSRIL 305
Cdd:TIGR00064 231 KLDGTAKGGIILSIAYELKLPIKFIGVGEKIDDLAPFDADWFVEALF 277
SRP54_G cd17875
GTPase domain of the signal recognition 54 kDa subunit; The signal recognition particle (SRP) ...
 102-304 6.74e-60

GTPase domain of the signal recognition 54 kDa subunit; The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal signal sequences of newly synthesized polypeptides at the ribosome. The SRP-polypeptide complex is then targeted to the membrane by an interaction between SRP and its cognated receptor (SR). In mammals, SRP consists of six protein subunits and a 7SL RNA. One of these subunits is a 54 kd protein (SRP54), which is a GTP-binding protein that interacts with the signal sequence when it emerges from the ribosome. SRP54 is a multidomain protein that consists of an N-terminal domain, followed by a central G (GTPase) domain and a C-terminal M domain.


Pssm-ID: 349784  Cd Length: 193  Bit Score: 195.87  E-value: 6.74e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207588923 102 VIMLAGLQGSGKTTLAGKLAFWLRNQGHTPLLVACDLQRPAAVNQLQVVGQRAGVPVFaphpgappsGPDTgpEGDPVAV 181
Cdd:cd17875     2 VIMFVGLQGSGKTTTAAKLAYYYQKKGYKVGLVCADTFRAGAFDQLKQNATKARVPFY---------GSYT--EKDPVKI 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207588923 182 AAAGLAEAQAKHHDVVIVDTAGRLGIDDELMSQAAAIRDAINPDEVIFVLDAMIGQDAVTTAEAFREGVGFTGVVLTKLD 261
Cdd:cd17875    71 AKEGVEKFKKEKFDIIIVDTSGRHKQEEELFEEMKQISDAVKPDEVILVIDASIGQAAEDQAKAFKEAVDIGSVIITKLD 150

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1207588923 262 GDARGGAALSVREVTGVPILFASTGEKLEDFDVFHPDRMSSRI 304
Cdd:cd17875   151 GHAKGGGALSAVAATGAPIIFIGTGEHIDDLEPFDPKRFVSRL 193
FtsY cd17874
signal recognition particle receptor FtsY; FtsY, the bacterial signal-recognition particle ...
 101-298 1.83e-57

signal recognition particle receptor FtsY; FtsY, the bacterial signal-recognition particle (SRP) receptor (SR), is homologous to the SRP receptor alpha-subunit (SRalpha) of the eukaryotic SR. It interacts with the signal-recognition particle (SRP) and is required for the co-translational membrane targeting of proteins.


Pssm-ID: 349783  Cd Length: 199  Bit Score: 189.70  E-value: 1.83e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207588923 101 TVIMLAGLQGSGKTTLAGKLAFWLRNQGHTPLLVACDLQRPAAVNQLQVVGQRAGVPVFAPHPGAppsgpdtgpegDPVA 180
Cdd:cd17874     1 FVILFVGVNGVGKTTTIGKLAHYLKNQGKKVVLAAGDTFRAAAVEQLEEWAERLGVPVISQNEGA-----------DPAA 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207588923 181 VAAAGLAEAQAKHHDVVIVDTAGRLGIDDELMSQAAAIRDAIN------PDEVIFVLDAMIGQDAVTTAEAFREGVGFTG 254
Cdd:cd17874    70 VAFDAIQAAKARGIDVVLIDTAGRLHTKKNLMEELKKIKRVIKkkdpeaPHEVLLVLDATTGQNALEQAKEFNEAVGLTG 149

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1207588923 255 VVLTKLDGDARGGAALSVREVTGVPILFASTGEKLEDFDVFHPD 298
Cdd:cd17874   150 IILTKLDGTAKGGIVLSIADELKIPVKFVGVGEGIDDLRPFDPE 193
SRP_SPB pfam02978
Signal peptide binding domain;
337-433 3.38e-41

Signal peptide binding domain;


Pssm-ID: 460771 [Multi-domain]  Cd Length: 95  Bit Score: 142.92  E-value: 3.38e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207588923 337 ELTLEDFLEQMLAIRKMGPIGNLLGMLPGAGQMRDAlaEVDDRQLDRLQAIIRGMTPQERADPKIINASRRLRIANGSGV 416
Cdd:pfam02978   1 KFTLRDFLEQLQQIKKMGPLSKILSMIPGMGKKDDD--IDSEKKLKRIEAIIDSMTPKERDNPDIINASRKRRIARGSGT 78

                          90
                  ....*....|....*..
gi 1207588923 417 TVAEVNQLVDRFFEARK 433
Cdd:pfam02978  79 SVQEVNRLLKQFKQMKK 95
SRalpha_C cd17876
C-terminal domain of signal recognition particle receptor alpha subunit; The ...
 102-298 1.42e-33

C-terminal domain of signal recognition particle receptor alpha subunit; The signal-recognition particle (SRP) receptor (SR) alpha-subunit (SRalpha) of the eukaryotic SR interacts with the signal-recognition particle (SRP) and is essential for the co-translational membrane targeting of proteins.


Pssm-ID: 349785  Cd Length: 204  Bit Score: 126.19  E-value: 1.42e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207588923 102 VIMLAGLQGSGKTTLAGKLAFWLRNQGHTPLLVACDLQRPAAVNQLQVVGQRAGVPVFaphpgappsgpDTGPEGDPVAV 181
Cdd:cd17876     2 VIVFCGVNGVGKSTNLAKIAYWLLSNGFRVLIAACDTFRSGAVEQLRTHARRLGVELY-----------EKGYGKDPAAV 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207588923 182 AAAGLAEAQAKHHDVVIVDTAGRLGIDDELMSQAAAIRDAINPDEVIFVLDAMIGQDAVTTAEAFREGV----------G 251
Cdd:cd17876    71 AKEAIKYARDQGFDVVLIDTAGRMQNNEPLMRALAKLIKENNPDLVLFVGEALVGNDAVDQLKKFNQALadyspsdnprL 150

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1207588923 252 FTGVVLTKLDG-DARGGAALSVREVTGVPILFASTGEKLEDFDVFHPD 298
Cdd:cd17876   151 IDGIVLTKFDTiDDKVGAALSMVYATGQPIVFVGTGQTYTDLKKLNVK 198
FlhF COG1419
Flagellar biosynthesis GTPase FlhF [Cell motility];
32-306 3.46e-30

Flagellar biosynthesis GTPase FlhF [Cell motility];


Pssm-ID: 441029 [Multi-domain]  Cd Length: 361  Bit Score: 121.13  E-value: 3.46e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207588923  32 REIRLALLEADVSLPVVRAFVGRIKERArgaevsgalnPAQQVVKIVNEELIGILGGQTRQLVfakTPPTVIMLAGLQGS 111
Cdd:COG1419   109 AELLERLLEAGVSPELARELLEKLPEDL----------SAEEAWRALLEALARRLPVAEDPLL---DEGGVIALVGPTGV 175

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207588923 112 GKTTLAGKLAFWL-RNQGHTPLLVACDLQRPAAVNQLQVVGQRAGVPVFAPHpgappsgpdtgpegDPvavAAAGLAEAQ 190
Cdd:COG1419   176 GKTTTIAKLAARFvLRGKKKVALITTDTYRIGAVEQLKTYARILGVPVEVAY--------------DP---EELKEALER 238

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207588923 191 AKHHDVVIVDTAGRLGIDDELMSQAAAIRDAINPDEVIFVLDA-MIGQDAVTTAEAFReGVGFTGVVLTKLDGDARGGAA 269
Cdd:COG1419   239 LRDKDLVLIDTAGRSPRDPELIEELKALLDAGPPIEVYLVLSAtTKYEDLKEIVEAFS-SLGLDGLILTKLDETASLGSI 317

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1207588923 270 LSVREVTGVPILFASTGEKL-EDFDVFHPDRMSSRILG 306
Cdd:COG1419   318 LNLLIRTGLPLSYITNGQRVpEDIEVADPERLARLLLG 355
SRP54_N pfam02881
SRP54-type protein, helical bundle domain;
5-82 4.24e-24

SRP54-type protein, helical bundle domain;


Pssm-ID: 460734 [Multi-domain]  Cd Length: 75  Bit Score: 95.61  E-value: 4.24e-24
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1207588923   5 LSDRLTGALAGLRGKGRLTDADIDATTREIRLALLEADVSLPVVRAFVGRIKERARGAEvsgALNPAQQVVKIVNEEL 82
Cdd:pfam02881   1 LGEKLSSLFKGLRGKGKIDEEDLEEALKELEEALLEADVGVEVVKKIIERLREKAVGEK---KLKPPQEVKKILKEEL 75
SRP54_N smart00963
SRP54-type protein, helical bundle domain; This entry represents the N-terminal helical bundle ...
 9-86 3.92e-22

SRP54-type protein, helical bundle domain; This entry represents the N-terminal helical bundle domain of the 54 kDa SRP54 component, a GTP-binding protein that interacts with the signal sequence when it emerges from the ribosome. SRP54 of the signal recognition particle has a three-domain structure: an N-terminal helical bundle domain, a GTPase domain, and the M-domain that binds the 7s RNA and also binds the signal sequence. The extreme C-terminal region is glycine-rich and lower in complexity and poorly conserved between species.


Pssm-ID: 214941 [Multi-domain]  Cd Length: 77  Bit Score: 90.30  E-value: 3.92e-22
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1207588923    9 LTGALAGLRGKGRLTDADIDATTREIRLALLEADVSLPVVRAFVGRIKERARGaEVSGALNPAQQVVKIVNEELIGIL 86
Cdd:smart00963   1 LSKALGKLLGELFLTEKDDEELLEELEEALLEADVGVEVVKEIIERVKEKAKG-EVLKGLTPKQEVKKILKEELVKIL 77
FlhF cd17873
signal-recognition particle GTPase FlhF; FlhF protein is a signal-recognition particle (SRP) ...
 102-304 4.73e-21

signal-recognition particle GTPase FlhF; FlhF protein is a signal-recognition particle (SRP)-type GTPase that is essential for the placement and assembly of polar flagella. It is similar to the 54 kd subunit (SRP54) of the signal recognition particle (SRP) that mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal signal sequences of newly synthesized polypeptides at the ribosome. The SRP-polypeptide complex is then targeted to the membrane by an interaction between SRP and its cognated receptor (SR).


Pssm-ID: 349782 [Multi-domain]  Cd Length: 189  Bit Score: 90.69  E-value: 4.73e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207588923 102 VIMLAGLQGSGKTTLAGKLA-FWLRNQGHTPLLVACDLQRPAAVNQLQVVGQRAGVPVfaphpgappsgpdtgpegDPVA 180
Cdd:cd17873     2 VIALVGPTGVGKTTTLAKLAaRYVLKKGKKVALITTDTYRIGAVEQLKTYAEIMGIPV------------------EVAE 63

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207588923 181 VAAA-GLAEAQAKHHDVVIVDTAGRLGIDDELMSQAAAIRDAINPDEVIFVLDA-MIGQDAVTTAEAFReGVGFTGVVLT 258
Cdd:cd17873    64 DPEDlADALERLSDRDLILIDTAGRSPRDKEQLEELKELLGAGEDIEVHLVLSAtTKAKDLKEIIERFS-PLGYRGLILT 142

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1207588923 259 KLDGDARGGAALSVREVTGVPILFASTGEKL-EDFDVFHPDRMSSRI 304
Cdd:cd17873   143 KLDETTSLGSVLSVLAESQLPVSYVTTGQRVpEDIEVASPLRLARLL 189
PRK12726 PRK12726
flagellar biosynthesis regulator FlhF; Provisional
 102-306 1.96e-11

flagellar biosynthesis regulator FlhF; Provisional


Pssm-ID: 183704 [Multi-domain]  Cd Length: 407  Bit Score: 65.91  E-value: 1.96e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207588923 102 VIMLAGLQGSGKTTLAGKLAFWLRNQGHTPLLVACDLQRPAAVNQLQVVGQRAGVPVFAPhpgappsgpdtgpeGDPVAV 181
Cdd:PRK12726  208 IISLIGQTGVGKTTTLVKLGWQLLKQNRTVGFITTDTFRSGAVEQFQGYADKLDVELIVA--------------TSPAEL 273

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207588923 182 AAAGLAEAQAKHHDVVIVDTAGRLGIDDELMSQAAAIRDAINPDEVIFVLDA-MIGQDAVTTAEAFREgVGFTGVVLTKL 260
Cdd:PRK12726  274 EEAVQYMTYVNCVDHILIDTVGRNYLAEESVSEISAYTDVVHPDLTCFTFSSgMKSADVMTILPKLAE-IPIDGFIITKM 352

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1207588923 261 DGDARGGAALSVREVTGVPILFASTGEKLEDfDVFHPDR--MSSRILG 306
Cdd:PRK12726  353 DETTRIGDLYTVMQETNLPVLYMTDGQNITE-NIFRPKSrwLAERFVG 399
flhF PRK11889
flagellar biosynthesis protein FlhF;
34-290 1.37e-10

flagellar biosynthesis protein FlhF;


Pssm-ID: 183360 [Multi-domain]  Cd Length: 436  Bit Score: 63.55  E-value: 1.37e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207588923  34 IRLaLLEADVSLPVVRAFVGRIKERARGAEVsgalnpaqqvvkIVNEELIGILGGQTR-----QLVFAKTPPTvIMLAGL 108
Cdd:PRK11889  184 IRM-LEQNDVEQYFIHAYAEKLKVKFENATM------------ITEEEVIEYILEDMRshfntENVFEKEVQT-IALIGP 249

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207588923 109 QGSGKTTLAGKLAFWLRNQGHTPLLVACDLQRPAAVNQLQVVGQRAGVPVFAPHpgappsgpdtgpegDPVAVAAAGLAE 188
Cdd:PRK11889  250 TGVGKTTTLAKMAWQFHGKKKTVGFITTDHSRIGTVQQLQDYVKTIGFEVIAVR--------------DEAAMTRALTYF 315

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207588923 189 AQAKHHDVVIVDTAGRLGIDDELMSQAAAIRDAINPDEVIFVLDA-MIGQDAVTTAEAFREgVGFTGVVLTKLDGDARGG 267
Cdd:PRK11889  316 KEEARVDYILIDTAGKNYRASETVEEMIETMGQVEPDYICLTLSAsMKSKDMIEIITNFKD-IHIDGIVFTKFDETASSG 394

                         250       260
                  ....*....|....*....|...
gi 1207588923 268 AALSVREVTGVPILFASTGEKLE 290
Cdd:PRK11889  395 ELLKIPAVSSAPIVLMTDGQDVK 417
flhF PRK06731
flagellar biosynthesis regulator FlhF; Validated
 34-290 2.12e-09

flagellar biosynthesis regulator FlhF; Validated


Pssm-ID: 75717 [Multi-domain]  Cd Length: 270  Bit Score: 58.60  E-value: 2.12e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207588923  34 IRLaLLEADVSLPVVRAFVGRIKERARGAEVSgalnpAQQVVKIVNEELIGILGGQTrqlVFAKTPPTvIMLAGLQGSGK 113
Cdd:PRK06731   19 IRM-LEQNDVEQYFIHAYAEKLKVKFENATMI-----TEEVIEYILEDMSSHFNTEN---VFEKEVQT-IALIGPTGVGK 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207588923 114 TTLAGKLAFWLRNQGHTPLLVACDLQRPAAVNQLQVVGQRAGVPVFAPHpgappsgpdtgpegDPVAVAAAGLAEAQAKH 193
Cdd:PRK06731   89 TTTLAKMAWQFHGKKKTVGFITTDHSRIGTVQQLQDYVKTIGFEVIAVR--------------DEAAMTRALTYFKEEAR 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207588923 194 HDVVIVDTAGRLGIDDELMSQAAAIRDAINPDEVIFVLDA-MIGQDAVTTAEAFREgVGFTGVVLTKLDGDARGGAALSV 272
Cdd:PRK06731  155 VDYILIDTAGKNYRASETVEEMIETMGQVEPDYICLTLSAsMKSKDMIEIITNFKD-IHIDGIVFTKFDETASSGELLKI 233

                         250
                  ....*....|....*...
gi 1207588923 273 REVTGVPILFASTGEKLE 290
Cdd:PRK06731  234 PAVSSAPIVLMTDGQDVK 251
flhF PRK05703
flagellar biosynthesis protein FlhF;
33-306 8.31e-09

flagellar biosynthesis protein FlhF;


Pssm-ID: 235570 [Multi-domain]  Cd Length: 424  Bit Score: 57.60  E-value: 8.31e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207588923  33 EIRLALLEADVSLPVVRAFVGRIKER--ARGAEVSGALnpAQQVVKIVNEELIGILGGQTrqlvfaktpptVIMLAGLQG 110
Cdd:PRK05703  165 ELYKRLKRSGLSPEIAEKLLKLLLEHmpPRERTAWRYL--LELLANMIPVRVEDILKQGG-----------VVALVGPTG 231

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207588923 111 SGKTT----LAGKLAfwLRNQGHTPLLVACDLQRPAAVNQLQVVGQRAGVPV--------FAphpgappsgpdtgpegdp 178
Cdd:PRK05703  232 VGKTTtlakLAARYA--LLYGKKKVALITLDTYRIGAVEQLKTYAKIMGIPVevvydpkeLA------------------ 291

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207588923 179 vavaaagLAEAQAKHHDVVIVDTAGRLGIDDELMSQAAA-IRDAINPDEVIFVLdAMIGQ--DAVTTAEAFREgVGFTGV 255
Cdd:PRK05703  292 -------KALEQLRDCDVILIDTAGRSQRDKRLIEELKAlIEFSGEPIDVYLVL-SATTKyeDLKDIYKHFSR-LPLDGL 362

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1207588923 256 VLTKLDGDARGGAALSVREVTGVPILFASTGEKL-EDFDVFHPDRMSSRILG 306
Cdd:PRK05703  363 IFTKLDETSSLGSILSLLIESGLPISYLTNGQRVpDDIKVANPEELVRLLLG 414
FlhF TIGR03499
flagellar biosynthetic protein FlhF; [Cellular processes, Chemotaxis and motility]
 32-160 7.07e-08

flagellar biosynthetic protein FlhF; [Cellular processes, Chemotaxis and motility]


Pssm-ID: 274609 [Multi-domain]  Cd Length: 282  Bit Score: 53.88  E-value: 7.07e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207588923  32 REIRLALLEADVSLPVVRAFVGRIKERARgaevsgalnpAQQVVKIVNEELIGILGGQTRQlVFAKTPPTVIMLAGLQGS 111
Cdd:TIGR03499 137 AKLYERLLEAGVSEELARELLEKLPEDAD----------AEDAWRWLREALEGMLPVKPEE-DPILEQGGVIALVGPTGV 205

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1207588923 112 GKTTLAGKLA--FWLRNQGHTPLLVACDLQRPAAVNQLQVVGQRAGVPVFA 160
Cdd:TIGR03499 206 GKTTTLAKLAarFALEHGKKKVALITTDTYRIGAVEQLKTYAEILGIPVKV 256
flhF PRK14722
flagellar biosynthesis regulator FlhF; Provisional
 102-291 8.82e-08

flagellar biosynthesis regulator FlhF; Provisional


Pssm-ID: 173185 [Multi-domain]  Cd Length: 374  Bit Score: 54.34  E-value: 8.82e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207588923 102 VIMLAGLQGSGKTTLAGKLAFW--LRNQGHTPLLVACDLQRPAAVNQLQVVGQRAGVPVFAPHPGappsgpdtgpeGDpv 179
Cdd:PRK14722  139 VFALMGPTGVGKTTTTAKLAARcvMRFGASKVALLTTDSYRIGGHEQLRIFGKILGVPVHAVKDG-----------GD-- 205

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207588923 180 avaaAGLAEAQAKHHDVVIVDTAGRLGIDDELMSQAAAIRDAINPDEVIFVLDAMIGQDAVT-TAEAFREGVG------- 251
Cdd:PRK14722  206 ----LQLALAELRNKHMVLIDTIGMSQRDRTVSDQIAMLHGADTPVQRLLLLNATSHGDTLNeVVQAYRSAAGqpkaalp 281

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1207588923 252 -FTGVVLTKLDGDARGGAALSVREVTGVPILFASTGEKLED 291
Cdd:PRK14722  282 dLAGCILTKLDEASNLGGVLDTVIRYKLPVHYVSTGQKVPE 322
flhF PRK14723
flagellar biosynthesis regulator FlhF; Provisional
 102-288 1.97e-07

flagellar biosynthesis regulator FlhF; Provisional


Pssm-ID: 237802 [Multi-domain]  Cd Length: 767  Bit Score: 53.65  E-value: 1.97e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207588923 102 VIMLAGLQGSGKTTLAGKLA--FWLRNQGHTPLLVACDLQRPAAVNQLQVVGQRAGVPVFAPHPGAppsgpdtgpegdpv 179
Cdd:PRK14723  187 VLALVGPTGVGKTTTTAKLAarCVAREGADQLALLTTDSFRIGALEQLRIYGRILGVPVHAVKDAA-------------- 252

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207588923 180 aVAAAGLAEAQAKHhdVVIVDTAGRLGIDDELMSQAAAIRDAINPDEVIFVLDAMIGQDAVT-TAEAFREGVG--FTGVV 256
Cdd:PRK14723  253 -DLRFALAALGDKH--LVLIDTVGMSQRDRNVSEQIAMLCGVGRPVRRLLLLNAASHGDTLNeVVHAYRHGAGedVDGCI 329

                         170       180       190
                  ....*....|....*....|....*....|..
gi 1207588923 257 LTKLDGDARGGAALSVREVTGVPILFASTGEK 288
Cdd:PRK14723  330 ITKLDEATHLGPALDTVIRHRLPVHYVSTGQK 361
PRK12727 PRK12727
flagellar biosynthesis protein FlhF;
85-291 3.87e-06

flagellar biosynthesis protein FlhF;


Pssm-ID: 237182 [Multi-domain]  Cd Length: 559  Bit Score: 49.60  E-value: 3.87e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207588923  85 ILGGQTRQLVFAKTPPT----VIMLAGLQGSGKTTLAGKLA--FWLRNQGHTPLLVACDLQRPAAVNQLQVVGQRAGVPV 158
Cdd:PRK12727  331 MLGLLSKRLPVAPVDPLerggVIALVGPTGAGKTTTIAKLAqrFAAQHAPRDVALVTTDTQRVGGREQLHSYGRQLGIAV 410

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207588923 159 FAPHPGAppsgpdtgpegdpvavaAAGLAEAQAKHHDVVIVDTAGRLGIDDELMSQAAAIRDA-------INPDEVIFV- 230
Cdd:PRK12727  411 HEADSAE-----------------SLLDLLERLRDYKLVLIDTAGMGQRDRALAAQLNWLRAArqvtsllVLPANAHFSd 473

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1207588923 231 LDAMIGQDAVTTAEafregvgftGVVLTKLDGDARGGAALSVREVTGVPILFASTGEKLED 291
Cdd:PRK12727  474 LDEVVRRFAHAKPQ---------GVVLTKLDETGRFGSALSVVVDHQMPITWVTDGQRVPD 525
SIMIBI cd01983
SIMIBI (signal recognition particle, MinD and BioD)-class NTPases; SIMIBI (after signal ...
 102-259 2.63e-05

SIMIBI (signal recognition particle, MinD and BioD)-class NTPases; SIMIBI (after signal recognition particle, MinD, and BioD), consists of signal recognition particle (SRP) GTPases, the assemblage of MinD-like ATPases, which are involved in protein localization, chromosome partitioning, and membrane transport, and a group of metabolic enzymes with kinase or related phosphate transferase activity. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion.


Pssm-ID: 349751 [Multi-domain]  Cd Length: 107  Bit Score: 43.19  E-value: 2.63e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207588923 102 VIMLAGLQ-GSGKTTLAGKLAFWLRNQGHTPLLVACDlqrpaavnqlqvvgqragvpvfaphpgappsgpdtgpegdpva 180
Cdd:cd01983     2 VIAVTGGKgGVGKTTLAAALAVALAAKGYKVLLIDLD------------------------------------------- 38

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207588923 181 vaaaglaeaqakhhDVVIVDTAGRLGIDDELMSQAAAIRDaINPDEVIFVLDAMIG--QDAVTTA---EAFREGVGFTGV 255
Cdd:cd01983    39 --------------DYVLIDGGGGLETGLLLGTIVALLAL-KKADEVIVVVDPELGslLEAVKLLlalLLLGIGIRPDGI 103


                  ....
gi 1207588923 256 VLTK 259
Cdd:cd01983   104 VLNK 107
PHA02518 PHA02518
ParA-like protein; Provisional
 110-288 2.93e-05

ParA-like protein; Provisional


Pssm-ID: 222854 [Multi-domain]  Cd Length: 211  Bit Score: 45.23  E-value: 2.93e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207588923 110 GSGKTTLAGKLAFWLRNQGHTPLLVACDLQRPAAvnqlqvvgqragvpvfaphpgappSGPDTGPEGDPVAVAAAGLAEA 189
Cdd:PHA02518   11 GAGKTTVATNLASWLHADGHKVLLVDLDPQGSST------------------------DWAEAREEGEPLIPVVRMGKSI 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207588923 190 QAKHH------DVVIVDTAGRlgiDDELMSQAAAIRDAI----NPDEV-IFVLDAMIgqDAVTTAEAFREGV-GFTGVVL 257
Cdd:PHA02518   67 RADLPkvasgyDYVVVDGAPQ---DSELARAALRIADMVlipvQPSPFdIWAAPDLV--ELIKARQEVTDGLpKFAFIIS 141

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1207588923 258 TKLDGDARGGAALSVREVTGVPILFASTGEK 288
Cdd:PHA02518  142 RAIKNTQLYREARKALAGYGLPILRNGTTQR 172
UMPK_like cd02028
Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the ...
 102-137 6.14e-05

Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK).


Pssm-ID: 238986 [Multi-domain]  Cd Length: 179  Bit Score: 43.83  E-value: 6.14e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1207588923 102 VIMLAGLQGSGKTTLAGKLAFWLRNQGHTPLLVACD 137
Cdd:cd02028     1 VVGIAGPSGSGKTTFAKKLSNQLRVNGIGPVVISLD 36
CbiA pfam01656
CobQ/CobB/MinD/ParA nucleotide binding domain; This family consists of various cobyrinic acid ...
 110-281 1.10e-04

CobQ/CobB/MinD/ParA nucleotide binding domain; This family consists of various cobyrinic acid a,c-diamide synthases. These include CbiA and CbiP from S.typhimurium, and CobQ from R. capsulatus. These amidases catalyze amidations to various side chains of hydrogenobyrinic acid or cobyrinic acid a,c-diamide in the biosynthesis of cobalamin (vitamin B12) from uroporphyrinogen III. Vitamin B12 is an important cofactor and an essential nutrient for many plants and animals and is primarily produced by bacteria. The family also contains dethiobiotin synthetases as well as the plasmid partitioning proteins of the MinD/ParA family.


Pssm-ID: 426369 [Multi-domain]  Cd Length: 228  Bit Score: 43.87  E-value: 1.10e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207588923 110 GSGKTTLAGKLAFWLRNQGHTPLLVACDLQRPAAVNQLQVVGQR-------AGVP--------VFAPH---------PGA 165
Cdd:pfam01656   9 GVGKTTLAANLARALARRGLRVLLIDLDPQSNNSSVEGLEGDIApalqalaEGLKgrvnldpiLLKEKsdeggldliPGN 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207588923 166 PP-SGPDTGPEGDPVAVAAAGLAEAQAKHHDVVIVDTAGRLGID--DELMSQAAAIRdAINPdEVIFVLDAmigQDAVTT 242
Cdd:pfam01656  89 IDlEKFEKELLGPRKEERLREALEALKEDYDYVIIDGAPGLGELlrNALIAADYVII-PLEP-EVILVEDA---KRLGGV 163

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1207588923 243 AEAFREGVG-----FTGVVLTKLDGDARGGAALSV--REVTGVPIL 281
Cdd:pfam01656 164 IAALVGGYAllglkIIGVVLNKVDGDNHGKLLKEAleELLRGLPVL 209
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 99-212 1.35e-04

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 42.36  E-value: 1.35e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207588923   99 PPTVIMLAGLQGSGKTTLAGKLAFWLRNQGHTPLLVACDLQRPAAVNQLQVVGqragvpvfaphpgappsGPDTGPEGDP 178
Cdd:smart00382   1 PGEVILIVGPPGSGKTTLARALARELGPPGGGVIYIDGEDILEEVLDQLLLII-----------------VGGKKASGSG 63

                           90       100       110
                   ....*....|....*....|....*....|....
gi 1207588923  179 VAVAAAGLAEAQAKHHDVVIVDTAGRLGIDDELM 212
Cdd:smart00382  64 ELRLRLALALARKLKPDVLILDEITSLLDAEQEA 97
ParAB_family cd02042
partition proteins ParAB family; ParA and ParB of Caulobacter crescentus belong to a conserved ...
 110-274 4.43e-04

partition proteins ParAB family; ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the initiation of DNA replication. ParB regulates the ParA ATPase activity by promoting nucleotide exchange in a fashion reminiscent of the exchange factors of eukaryotic G proteins. ADP-bound ParA binds single-stranded DNA, whereas the ATP-bound form dissociates ParB from its DNA binding sites. Increasing the fraction of ParA-ADP in the cell inhibits cell division, suggesting that this simple nucleotide switch may regulate cytokinesis. ParA shares sequence similarity to a conserved and widespread family of ATPases which includes the repA protein of the repABC operon in Rhizobium etli symbiotic plasmid. This operon is involved in the plasmid replication and partition.


Pssm-ID: 349760 [Multi-domain]  Cd Length: 130  Bit Score: 40.22  E-value: 4.43e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207588923 110 GSGKTTLAGKLAFWLRNQGHTPLLVACDLQRPAAvnqlqvvgqragvpvfaphpgappsgpdtgpegdpvavaaaglaea 189
Cdd:cd02042    11 GVGKTTLAVNLAAALALRGKRVLLIDLDPQGSLT---------------------------------------------- 44

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207588923 190 qAKHHDVVIVDTAGRLGIddeLMSQAAAIRDAI----NPDEviFVLDAMigQDAVTTAEAFREGVG----FTGVVLTKLd 261
Cdd:cd02042    45 -SWLYDYILIDTPPSLGL---LTRNALAAADLVlipvQPSP--FDLDGL--AKLLDTLEELKKQLNppllILGILLTRV- 115

                         170
                  ....*....|...
gi 1207588923 262 gDARGGAALSVRE 274
Cdd:cd02042   116 -DPRTKLAREVLE 127
arsen_driv_ArsA TIGR04291
arsenical pump-driving ATPase; The broader family (TIGR00345) to which the current family ...
 96-149 3.64e-03

arsenical pump-driving ATPase; The broader family (TIGR00345) to which the current family belongs consists of transport-energizing ATPases, including to TRC40/GET3 family involved in post-translational insertion of protein C-terminal transmembrane anchors into membranes from the cyotosolic face. This family, however, is restricted to ATPases that energize pumps that export arsenite (or antimonite).


Pssm-ID: 275109 [Multi-domain]  Cd Length: 566  Bit Score: 40.07  E-value: 3.64e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1207588923  96 AKTPPTVIMLAGLQGSGKTTLAGKLAFWLRNQGHTPLLVACDlqrPAA---------VNQLQV 149
Cdd:TIGR04291 317 AKSEKGLIMTMGKGGVGKTTVAAAIAVRLANKGLDVHLTTSD---PAAhlsvtltgsLNNLQV 376
CysC COG0529
Adenylylsulfate kinase or related kinase [Inorganic ion transport and metabolism]; ...
 97-133 4.47e-03

Adenylylsulfate kinase or related kinase [Inorganic ion transport and metabolism]; Adenylylsulfate kinase or related kinase is part of the Pathway/BioSystem: Cysteine biosynthesis


Pssm-ID: 440295 [Multi-domain]  Cd Length: 189  Bit Score: 38.53  E-value: 4.47e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1207588923  97 KTPPTVIMLAGLQGSGKTTLAGKLAFWLRNQG-HTPLL 133
Cdd:COG0529    13 GQKGFVVWFTGLSGSGKSTLANALERRLFERGrHVYLL 50
COG4639 COG4639
Predicted kinase [General function prediction only];
99-121 8.77e-03

Predicted kinase [General function prediction only];


Pssm-ID: 443677 [Multi-domain]  Cd Length: 145  Bit Score: 36.73  E-value: 8.77e-03
                          10        20
                  ....*....|....*....|...
gi 1207588923  99 PPTVIMLAGLQGSGKTTLAGKLA 121
Cdd:COG4639     1 MLSLVVLIGLPGSGKSTFARRLF 23
GPN1 cd17870
GPN-loop GTPase 1; GPN-loop GTPase 1 (GPN1, also kown as MBD2-interacting protein or MBDin, ...
 101-143 8.78e-03

GPN-loop GTPase 1; GPN-loop GTPase 1 (GPN1, also kown as MBD2-interacting protein or MBDin, RNAPII-associated protein 4, and XPA-binding protein 1) is a GTPase is required for nuclear targeting of RNA polymerase II. It forms heterodimers with GPN3.


Pssm-ID: 349779 [Multi-domain]  Cd Length: 241  Bit Score: 37.93  E-value: 8.78e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1207588923 101 TVIMLAGLQGSGKTTLAGKLAFWLRNQGHTPLLVACDlqrPAA 143
Cdd:cd17870     1 VVIIVVGMAGSGKTTFVQRLNAYLHDNKKPPYVINLD---PAV 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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