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Conserved domains on  [gi|1877522895|dbj|BBS85371|]
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potassium transporter KtrA [Aeromonas media]

Protein Classification

potassium channel family protein( domain architecture ID 11426271)

potassium channel family protein spans the cell membrane to form a conduction pathway or pore, through which selective ions such as potassium, sodium, and calcium translocate across cell membranes, similar to Trk system potassium uptake protein TrkA

CATH:  1.20.5.870|3.30.70.1450|3.40.50.720
Gene Ontology:  GO:0016020|GO:0022857|GO:0030001|GO:0034220
PubMed:  15816170|9525859|11836519|1772658|11178249
SCOP:  4000005|4000027
TCDB:  1.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TrkA COG0569
Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion ...
 1-202 8.67e-50

Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion transport and metabolism, Signal transduction mechanisms];


:

Pssm-ID: 440335 [Multi-domain]  Cd Length: 296  Bit Score: 163.70  E-value: 8.67e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1877522895   1 MNNQFAVIGLGLFGSALCEELQLQNAEVLAIDIDESKTRQIATLCNHVIVADATDEATVAELGLANFDIVFVAIGDnLET 80
Cdd:COG0569    94 LKMHVIIIGAGRVGRSLARELEEEGHDVVVIDKDPERVERLAEEDVLVIVGDATDEEVLEEAGIEDADAVIAATGD-DEA 172

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1877522895  81 SILTTLVLKEAGVKKVWVKARDKFHAKILQKVGADKVINPEWDMGRRVAQSMLDNRLFDYLELGH-EMVLTEFVIGLQQN 159
Cdd:COG0569   173 NILACLLAKELGVPRIIARANDPEYADLLERLGADVVISPERLAARRIARLLLRPGVLDVLELADgDAEIVEVTVPEGSP 252

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1877522895 160 --GRTLADLNLLQQNDFQLLAIKRGEVLHNVlTGKMELQLGDILI 202
Cdd:COG0569   253 lvGKTLKELDLRERYGVTVVAIKRGGEVIIP-SGDTVLEAGDELI 296
 
Name Accession Description Interval E-value
TrkA COG0569
Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion ...
 1-202 8.67e-50

Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion transport and metabolism, Signal transduction mechanisms];


Pssm-ID: 440335 [Multi-domain]  Cd Length: 296  Bit Score: 163.70  E-value: 8.67e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1877522895   1 MNNQFAVIGLGLFGSALCEELQLQNAEVLAIDIDESKTRQIATLCNHVIVADATDEATVAELGLANFDIVFVAIGDnLET 80
Cdd:COG0569    94 LKMHVIIIGAGRVGRSLARELEEEGHDVVVIDKDPERVERLAEEDVLVIVGDATDEEVLEEAGIEDADAVIAATGD-DEA 172

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1877522895  81 SILTTLVLKEAGVKKVWVKARDKFHAKILQKVGADKVINPEWDMGRRVAQSMLDNRLFDYLELGH-EMVLTEFVIGLQQN 159
Cdd:COG0569   173 NILACLLAKELGVPRIIARANDPEYADLLERLGADVVISPERLAARRIARLLLRPGVLDVLELADgDAEIVEVTVPEGSP 252

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1877522895 160 --GRTLADLNLLQQNDFQLLAIKRGEVLHNVlTGKMELQLGDILI 202
Cdd:COG0569   253 lvGKTLKELDLRERYGVTVVAIKRGGEVIIP-SGDTVLEAGDELI 296
TrkA_N pfam02254
TrkA-N domain; This domain is found in a wide variety of proteins. These proteins include ...
 5-120 4.29e-29

TrkA-N domain; This domain is found in a wide variety of proteins. These proteins include potassium channels, phosphoesterases, and various other transporters. This domain binds to NAD.


Pssm-ID: 426679 [Multi-domain]  Cd Length: 115  Bit Score: 104.92  E-value: 4.29e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1877522895   5 FAVIGLGLFGSALCEELQlQNAEVLAIDIDESKTRQIATLCNHVIVADATDEATVAELGLANFDIVFVAIGDNlETSILT 84
Cdd:pfam02254   1 IIIIGYGRVGRSLAEELS-EGGDVVVIDKDEERVEELREEGVPVVVGDATDEEVLEEAGIEEADAVIAATGDD-EANILI 78

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1877522895  85 TLVLKE-AGVKKVWVKARDKFHAKILQKVGADKVINP 120
Cdd:pfam02254  79 VLLARElNPDKKIIARANDPEHAELLRRLGADHVISP 115
trkA PRK09496
Trk system potassium transporter TrkA;
7-120 5.71e-11

Trk system potassium transporter TrkA;


Pssm-ID: 236541 [Multi-domain]  Cd Length: 453  Bit Score: 60.91  E-value: 5.71e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1877522895   7 VIGLGLFGSALCEELQLQNAEVLAIDIDESKTRQIATLCNHVIV--ADATDEATVAELGLANFDiVFVAIGDNLETSILT 84
Cdd:PRK09496  236 IVGGGNIGYYLAKLLEKEGYSVKLIERDPERAEELAEELPNTLVlhGDGTDQELLEEEGIDEAD-AFIALTNDDEANILS 314

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1877522895  85 TLVLKEAGVKKVWVKARDKFHAKILQKVGADKVINP 120
Cdd:PRK09496  315 SLLAKRLGAKKVIALVNRPAYVDLVEGLGIDIAISP 350
UDP_AE_SDR_e cd05256
UDP-N-acetylglucosamine 4-epimerase, extended (e) SDRs; This subgroup contains ...
 9-96 2.77e-03

UDP-N-acetylglucosamine 4-epimerase, extended (e) SDRs; This subgroup contains UDP-N-acetylglucosamine 4-epimerase of Pseudomonas aeruginosa, WbpP, an extended SDR, that catalyzes the NAD+ dependent conversion of UDP-GlcNAc and UDPGalNA to UDP-Glc and UDP-Gal. This subgroup has the characteristic active site tetrad and NAD-binding motif of the extended SDRs. Extended SDRs are distinct from classical SDRs. In addition to the Rossmann fold (alpha/beta folding pattern with a central beta-sheet) core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids. Extended SDRs are a diverse collection of proteins, and include isomerases, epimerases, oxidoreductases, and lyases; they typically have a TGXXGXXG cofactor binding motif. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.


Pssm-ID: 187566 [Multi-domain]  Cd Length: 304  Bit Score: 37.97  E-value: 2.77e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1877522895   9 GLGLFGSALCEELQLQNAEVLAID---------IDESKTRQiatlcnHVIVADATDEATVAELgLANFDIVF--VAIGDN 77
Cdd:cd05256     7 GAGFIGSHLVERLLERGHEVIVLDnlstgkkenLPEVKPNV------KFIEGDIRDDELVEFA-FEGVDYVFhqAAQASV 79

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1877522895  78 ----------LETSILTTLVL----KEAGVKKV 96
Cdd:cd05256    80 prsiedpikdHEVNVLGTLNLleaaRKAGVKRF 112
 
Name Accession Description Interval E-value
TrkA COG0569
Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion ...
 1-202 8.67e-50

Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion transport and metabolism, Signal transduction mechanisms];


Pssm-ID: 440335 [Multi-domain]  Cd Length: 296  Bit Score: 163.70  E-value: 8.67e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1877522895   1 MNNQFAVIGLGLFGSALCEELQLQNAEVLAIDIDESKTRQIATLCNHVIVADATDEATVAELGLANFDIVFVAIGDnLET 80
Cdd:COG0569    94 LKMHVIIIGAGRVGRSLARELEEEGHDVVVIDKDPERVERLAEEDVLVIVGDATDEEVLEEAGIEDADAVIAATGD-DEA 172

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1877522895  81 SILTTLVLKEAGVKKVWVKARDKFHAKILQKVGADKVINPEWDMGRRVAQSMLDNRLFDYLELGH-EMVLTEFVIGLQQN 159
Cdd:COG0569   173 NILACLLAKELGVPRIIARANDPEYADLLERLGADVVISPERLAARRIARLLLRPGVLDVLELADgDAEIVEVTVPEGSP 252

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1877522895 160 --GRTLADLNLLQQNDFQLLAIKRGEVLHNVlTGKMELQLGDILI 202
Cdd:COG0569   253 lvGKTLKELDLRERYGVTVVAIKRGGEVIIP-SGDTVLEAGDELI 296
TrkA_N pfam02254
TrkA-N domain; This domain is found in a wide variety of proteins. These proteins include ...
 5-120 4.29e-29

TrkA-N domain; This domain is found in a wide variety of proteins. These proteins include potassium channels, phosphoesterases, and various other transporters. This domain binds to NAD.


Pssm-ID: 426679 [Multi-domain]  Cd Length: 115  Bit Score: 104.92  E-value: 4.29e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1877522895   5 FAVIGLGLFGSALCEELQlQNAEVLAIDIDESKTRQIATLCNHVIVADATDEATVAELGLANFDIVFVAIGDNlETSILT 84
Cdd:pfam02254   1 IIIIGYGRVGRSLAEELS-EGGDVVVIDKDEERVEELREEGVPVVVGDATDEEVLEEAGIEEADAVIAATGDD-EANILI 78

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1877522895  85 TLVLKE-AGVKKVWVKARDKFHAKILQKVGADKVINP 120
Cdd:pfam02254  79 VLLARElNPDKKIIARANDPEHAELLRRLGADHVISP 115
Kch COG1226
Voltage-gated potassium channel Kch [Inorganic ion transport and metabolism];
7-133 8.59e-13

Voltage-gated potassium channel Kch [Inorganic ion transport and metabolism];


Pssm-ID: 440839 [Multi-domain]  Cd Length: 279  Bit Score: 65.52  E-value: 8.59e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1877522895   7 VIGLGLFGSALCEELQLQNAEVLAIDIDESKTRQIATLCNHVIVADATDEATVAELGLANFDIVFVAIGDNLETSILTTL 86
Cdd:COG1226   129 IAGFGRVGQIVARLLRAEGIPFVVIDLDPERVEELRRFGIKVYYGDATRPDVLEAAGIERARALVVAIDDPEAALRIVEL 208

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1877522895  87 VLKEAGVKKVWVKARDKFHAKILQKVGADKVINPEWDMGRRVAQSML 133
Cdd:COG1226   209 ARELNPDLKIIARARDREHAEELRQAGADEVVRETFESALQLARHAL 255
trkA PRK09496
Trk system potassium transporter TrkA;
7-120 5.71e-11

Trk system potassium transporter TrkA;


Pssm-ID: 236541 [Multi-domain]  Cd Length: 453  Bit Score: 60.91  E-value: 5.71e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1877522895   7 VIGLGLFGSALCEELQLQNAEVLAIDIDESKTRQIATLCNHVIV--ADATDEATVAELGLANFDiVFVAIGDNLETSILT 84
Cdd:PRK09496  236 IVGGGNIGYYLAKLLEKEGYSVKLIERDPERAEELAEELPNTLVlhGDGTDQELLEEEGIDEAD-AFIALTNDDEANILS 314

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1877522895  85 TLVLKEAGVKKVWVKARDKFHAKILQKVGADKVINP 120
Cdd:PRK09496  315 SLLAKRLGAKKVIALVNRPAYVDLVEGLGIDIAISP 350
WcaG COG0451
Nucleoside-diphosphate-sugar epimerase [Cell wall/membrane/envelope biogenesis];
9-96 2.35e-07

Nucleoside-diphosphate-sugar epimerase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440220 [Multi-domain]  Cd Length: 295  Bit Score: 49.98  E-value: 2.35e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1877522895   9 GLGLFGSALCEELQLQNAEVLAIDIDESKTRQIATLCN-HVIVADATDEATVAELgLANFDIVF-------VAIGD---N 77
Cdd:COG0451     7 GAGFIGSHLARRLLARGHEVVGLDRSPPGAANLAALPGvEFVRGDLRDPEALAAA-LAGVDAVVhlaapagVGEEDpdeT 85

                          90       100
                  ....*....|....*....|...
gi 1877522895  78 LETSILTTLVL----KEAGVKKV 96
Cdd:COG0451    86 LEVNVEGTLNLleaaRAAGVKRF 108
TrkA_C pfam02080
TrkA-C domain; This domain is often found next to the pfam02254 domain. The exact function of ...
 160-211 3.41e-06

TrkA-C domain; This domain is often found next to the pfam02254 domain. The exact function of this domain is unknown. It has been suggested that it may bind an unidentified ligand. The domain is predicted to adopt an all beta structure.


Pssm-ID: 460440 [Multi-domain]  Cd Length: 70  Bit Score: 43.37  E-value: 3.41e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1877522895 160 GRTLADLNLLQQNDFQLLAIKRGEVLhNVLTGKMELQLGDILILAGNKHAID 211
Cdd:pfam02080  14 GKTLKELNLPERFGVRIVAIRRGGRL-IIPSGDTVLEAGDRLLVIGTPDDLA 64
trkA PRK09496
Trk system potassium transporter TrkA;
7-212 5.59e-06

Trk system potassium transporter TrkA;


Pssm-ID: 236541 [Multi-domain]  Cd Length: 453  Bit Score: 46.27  E-value: 5.59e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1877522895   7 VIGLGLFGSALCEELQLQNAEVLAIDIDESKTRQIA-TLCNHVIVADATDEATVAELGLANFDIvFVAIGDNLETSILTT 85
Cdd:PRK09496    5 IVGAGQVGYTLAENLSGENNDVTVIDTDEERLRRLQdRLDVRTVVGNGSSPDVLREAGAEDADL-LIAVTDSDETNMVAC 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1877522895  86 LVLKE-AGVKK--VWVKA------RDKFHAKILqkvGADKVINPEWDMGRRVAQSMLDNRLFDYLELGHEMV-LTEFVI- 154
Cdd:PRK09496   84 QIAKSlFGAPTtiARVRNpeyaeyDKLFSKEAL---GIDLLISPELLVAREIARLIEYPGALDVEEFADGRVqLVEVKVy 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1877522895 155 -GLQQNGRTLADLNLLQQN-DFQLLAIKR-GEVLhnVLTGKMELQLGDILILAGNKHAIDH 212
Cdd:PRK09496  161 eGSPLVGKPLSDLREHFPDiDVRVVAIFRgGRLI--IPRGDTVIEAGDEVYFIGAREHIRA 219
NAD_binding_10 pfam13460
NAD(P)H-binding;
14-98 1.21e-05

NAD(P)H-binding;


Pssm-ID: 463885 [Multi-domain]  Cd Length: 183  Bit Score: 44.13  E-value: 1.21e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1877522895  14 GSALCEELQLQNAEVLAIDIDESKTRQIATLCN-HVIVADATDEATVAELgLANFDIVFVAIGDNLETSILTTLVL---K 89
Cdd:pfam13460   7 GRLLVKQLLARGHEVTALVRNPEKLADLEDHPGvEVVDGDVLDPDDLAEA-LAGQDAVISALGGGGTDETGAKNIIdaaK 85

                          90
                  ....*....|
gi 1877522895  90 EAGVKK-VWV 98
Cdd:pfam13460  86 AAGVKRfVLV 95
YbjL COG2985
Uncharacterized membrane protein YbjL, putative transporter [General function prediction only]; ...
 129-212 4.46e-05

Uncharacterized membrane protein YbjL, putative transporter [General function prediction only];


Pssm-ID: 442224 [Multi-domain]  Cd Length: 543  Bit Score: 43.57  E-value: 4.46e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1877522895 129 AQSMLDNRLFDYLELGHEMVLTEFVIGLQQ-NGRTLADLNLLQQNDFQLLAIKRGEV-LhnVLTGKMELQLGDILILAGN 206
Cdd:COG2985   268 AEALLGEEVDDSELLDSDLDVRRIVVTNKEvAGKTLGELNLRNRFGVVITRVRRGGVeL--PATPDTVLQLGDRLTVVGP 345


                  ....*.
gi 1877522895 207 KHAIDH 212
Cdd:COG2985   346 KEDVER 351
KhtT COG0490
K+/H+ antiporter KhtSTU, c-di-AMP-binding regulatory subunit KhtT, contains RCK_C (TrkA_C) ...
 160-211 4.76e-05

K+/H+ antiporter KhtSTU, c-di-AMP-binding regulatory subunit KhtT, contains RCK_C (TrkA_C) domain [Inorganic ion transport and metabolism, Signal transduction mechanisms];


Pssm-ID: 440256 [Multi-domain]  Cd Length: 140  Bit Score: 41.83  E-value: 4.76e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1877522895 160 GRTLADLNLLQQNDFQLLAIKRGEVLHNVLTGKMELQLGDILILAGNKHAID 211
Cdd:COG0490    83 GKTLGELNLRQRTGVTVVAIRRGGEVILSPGPDTVLEAGDTLVVVGTREQLE 134
YbjL COG2985
Uncharacterized membrane protein YbjL, putative transporter [General function prediction only]; ...
 160-211 1.35e-03

Uncharacterized membrane protein YbjL, putative transporter [General function prediction only];


Pssm-ID: 442224 [Multi-domain]  Cd Length: 543  Bit Score: 38.95  E-value: 1.35e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1877522895 160 GRTLADLNLLQQNDFQLLAIKRGEVLHNVlTGKMELQLGDILILAGNKHAID 211
Cdd:COG2985   216 GKTVAELEALLGTRVVISRIRRGGEIIVP-TPDTVLQEGDIVLVVGTREALE 266
UDP_AE_SDR_e cd05256
UDP-N-acetylglucosamine 4-epimerase, extended (e) SDRs; This subgroup contains ...
 9-96 2.77e-03

UDP-N-acetylglucosamine 4-epimerase, extended (e) SDRs; This subgroup contains UDP-N-acetylglucosamine 4-epimerase of Pseudomonas aeruginosa, WbpP, an extended SDR, that catalyzes the NAD+ dependent conversion of UDP-GlcNAc and UDPGalNA to UDP-Glc and UDP-Gal. This subgroup has the characteristic active site tetrad and NAD-binding motif of the extended SDRs. Extended SDRs are distinct from classical SDRs. In addition to the Rossmann fold (alpha/beta folding pattern with a central beta-sheet) core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids. Extended SDRs are a diverse collection of proteins, and include isomerases, epimerases, oxidoreductases, and lyases; they typically have a TGXXGXXG cofactor binding motif. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.


Pssm-ID: 187566 [Multi-domain]  Cd Length: 304  Bit Score: 37.97  E-value: 2.77e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1877522895   9 GLGLFGSALCEELQLQNAEVLAID---------IDESKTRQiatlcnHVIVADATDEATVAELgLANFDIVF--VAIGDN 77
Cdd:cd05256     7 GAGFIGSHLVERLLERGHEVIVLDnlstgkkenLPEVKPNV------KFIEGDIRDDELVEFA-FEGVDYVFhqAAQASV 79

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1877522895  78 ----------LETSILTTLVL----KEAGVKKV 96
Cdd:cd05256    80 prsiedpikdHEVNVLGTLNLleaaRKAGVKRF 112
AdhP COG1064
D-arabinose 1-dehydrogenase, Zn-dependent alcohol dehydrogenase family [Carbohydrate transport ...
 6-82 5.55e-03

D-arabinose 1-dehydrogenase, Zn-dependent alcohol dehydrogenase family [Carbohydrate transport and metabolism];


Pssm-ID: 440684 [Multi-domain]  Cd Length: 332  Bit Score: 37.01  E-value: 5.55e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1877522895   6 AVIG---LGLFGSALceeLQLQNAEVLAIDIDESKTRQIATL-CNHVIVADATD-EATVAELGLANFDIVFVAIGDNLET 80
Cdd:COG1064   167 AVIGaggLGHLAVQI---AKALGAEVIAVDRSPEKLELARELgADHVVNSSDEDpVEAVRELTGADVVIDTVGAPATVNA 243


                  ..
gi 1877522895  81 SI 82
Cdd:COG1064   244 AL 245
COG3273 COG3273
Uncharacterized protein, contains PhoU and TrkA_C domains [General function prediction only];
160-212 6.77e-03

Uncharacterized protein, contains PhoU and TrkA_C domains [General function prediction only];


Pssm-ID: 442504 [Multi-domain]  Cd Length: 387  Bit Score: 36.95  E-value: 6.77e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1877522895 160 GRTLADLNLLQQNDFQLLAIKRGEVLHNVLTGKMELQLGDILILAGNKHAIDH 212
Cdd:COG3273   328 GKTLGELKLETETGVRVIAIRRGGGWIYDPDGDTRLRAGDVLIVKGTREGLER 380
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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