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Conserved domains on  [gi|1915228680|dbj|BBV86169|]
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membrane protein [Enterobacter kobei]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
T3SS_CigR_fam NF040487
anti-virulence regulator CigR family protein; Members of this family are full-length homologs ...
 8-172 4.08e-64

anti-virulence regulator CigR family protein; Members of this family are full-length homologs of CigR, an inner membrane protein that appears to act as an anti-virulence factor. It was previously thought to be exported as a type III secretion system (T3SS) effector. A low-complexity, variable length repetitive region, rich in Gly, Pro, His, Lys, and Asn, separates a short, hydrophobic N-terminal domain from a longer, well-conserved C-terminal domain. A short stretch of that C-terminal domain, about 25 amino acids long, shows similarity to the C-terminal half of the domain described by Pfam model PF11776.10 (RcnB), but similarity between CigR and RcnB is not extensive.


:

Pssm-ID: 468512 [Multi-domain]  Cd Length: 147  Bit Score: 193.52  E-value: 4.08e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915228680   8 TTALAVVLSLTFAAAPVMANPGNGNGGGhgngggqgnggnhgngnsgnhgnKQNSGQDNPG----KSDKSFKSSKDVGND 83
Cdd:NF040487    1 LAALAAVLSLALGSAPALADPGNGKGNG-----------------------NGNGGHGNHGnkgnGGNGGKKKNGGDPDL 57

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915228680  84 VDARVSFDHARHLALNYGLTGYESLPPGIAKNLARGKPLPPGIAKKTVPASMLGQLPSYPGYEWRVVGDDLVLIALSTAI 163
Cdd:NF040487   58 VGPSISYGRARGLAVNYGLTGYSSLPPGIAKNLARGKPLPPGIAKKAVPGRMLGQLPHYPGYEWRQAGTDLVLVALATGI 137


                  ....*....
gi 1915228680 164 VTSVINGVF 172
Cdd:NF040487  138 VYEVLNGVF 146
 
Name Accession Description Interval E-value
T3SS_CigR_fam NF040487
anti-virulence regulator CigR family protein; Members of this family are full-length homologs ...
 8-172 4.08e-64

anti-virulence regulator CigR family protein; Members of this family are full-length homologs of CigR, an inner membrane protein that appears to act as an anti-virulence factor. It was previously thought to be exported as a type III secretion system (T3SS) effector. A low-complexity, variable length repetitive region, rich in Gly, Pro, His, Lys, and Asn, separates a short, hydrophobic N-terminal domain from a longer, well-conserved C-terminal domain. A short stretch of that C-terminal domain, about 25 amino acids long, shows similarity to the C-terminal half of the domain described by Pfam model PF11776.10 (RcnB), but similarity between CigR and RcnB is not extensive.


Pssm-ID: 468512 [Multi-domain]  Cd Length: 147  Bit Score: 193.52  E-value: 4.08e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915228680   8 TTALAVVLSLTFAAAPVMANPGNGNGGGhgngggqgnggnhgngnsgnhgnKQNSGQDNPG----KSDKSFKSSKDVGND 83
Cdd:NF040487    1 LAALAAVLSLALGSAPALADPGNGKGNG-----------------------NGNGGHGNHGnkgnGGNGGKKKNGGDPDL 57

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915228680  84 VDARVSFDHARHLALNYGLTGYESLPPGIAKNLARGKPLPPGIAKKTVPASMLGQLPSYPGYEWRVVGDDLVLIALSTAI 163
Cdd:NF040487   58 VGPSISYGRARGLAVNYGLTGYSSLPPGIAKNLARGKPLPPGIAKKAVPGRMLGQLPHYPGYEWRQAGTDLVLVALATGI 137


                  ....*....
gi 1915228680 164 VTSVINGVF 172
Cdd:NF040487  138 VYEVLNGVF 146
RcnB COG5455
Periplasmic regulator RcnB of Ni and Co efflux [Inorganic ion transport and metabolism];
91-170 2.00e-03

Periplasmic regulator RcnB of Ni and Co efflux [Inorganic ion transport and metabolism];


Pssm-ID: 444206 [Multi-domain]  Cd Length: 121  Bit Score: 36.23  E-value: 2.00e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915228680  91 DHARHLALNYGLTGYESLPPGIAKNLARGKPLPPGIAKKT--VPASMLGQLPSYP-GYEWRVVGDDLVLIALSTAIVTSV 167
Cdd:COG5455    38 RDDRHDDPGHRDKHRGAGPGEDYKRWRRGDRLPPEYRGRRyvVNDWRRYGLPAPPrGYHWVRVGGDYVLVAIATGIIVSI 117


                  ...
gi 1915228680 168 ING 170
Cdd:COG5455   118 VLG 120
 
Name Accession Description Interval E-value
T3SS_CigR_fam NF040487
anti-virulence regulator CigR family protein; Members of this family are full-length homologs ...
 8-172 4.08e-64

anti-virulence regulator CigR family protein; Members of this family are full-length homologs of CigR, an inner membrane protein that appears to act as an anti-virulence factor. It was previously thought to be exported as a type III secretion system (T3SS) effector. A low-complexity, variable length repetitive region, rich in Gly, Pro, His, Lys, and Asn, separates a short, hydrophobic N-terminal domain from a longer, well-conserved C-terminal domain. A short stretch of that C-terminal domain, about 25 amino acids long, shows similarity to the C-terminal half of the domain described by Pfam model PF11776.10 (RcnB), but similarity between CigR and RcnB is not extensive.


Pssm-ID: 468512 [Multi-domain]  Cd Length: 147  Bit Score: 193.52  E-value: 4.08e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915228680   8 TTALAVVLSLTFAAAPVMANPGNGNGGGhgngggqgnggnhgngnsgnhgnKQNSGQDNPG----KSDKSFKSSKDVGND 83
Cdd:NF040487    1 LAALAAVLSLALGSAPALADPGNGKGNG-----------------------NGNGGHGNHGnkgnGGNGGKKKNGGDPDL 57

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915228680  84 VDARVSFDHARHLALNYGLTGYESLPPGIAKNLARGKPLPPGIAKKTVPASMLGQLPSYPGYEWRVVGDDLVLIALSTAI 163
Cdd:NF040487   58 VGPSISYGRARGLAVNYGLTGYSSLPPGIAKNLARGKPLPPGIAKKAVPGRMLGQLPHYPGYEWRQAGTDLVLVALATGI 137


                  ....*....
gi 1915228680 164 VTSVINGVF 172
Cdd:NF040487  138 VYEVLNGVF 146
RcnB COG5455
Periplasmic regulator RcnB of Ni and Co efflux [Inorganic ion transport and metabolism];
91-170 2.00e-03

Periplasmic regulator RcnB of Ni and Co efflux [Inorganic ion transport and metabolism];


Pssm-ID: 444206 [Multi-domain]  Cd Length: 121  Bit Score: 36.23  E-value: 2.00e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915228680  91 DHARHLALNYGLTGYESLPPGIAKNLARGKPLPPGIAKKT--VPASMLGQLPSYP-GYEWRVVGDDLVLIALSTAIVTSV 167
Cdd:COG5455    38 RDDRHDDPGHRDKHRGAGPGEDYKRWRRGDRLPPEYRGRRyvVNDWRRYGLPAPPrGYHWVRVGGDYVLVAIATGIIVSI 117


                  ...
gi 1915228680 168 ING 170
Cdd:COG5455   118 VLG 120
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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