|
Name |
Accession |
Description |
Interval |
E-value |
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
1-456 |
0e+00 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 804.54 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 1 MIGSLTARIFAIFWLTLALVLMLVLMLPKLDSRQMTELLESEQRQGIMIEQHVEAELANDPPNDLMWWRRLFRAIDKWAP 80
Cdd:PRK09470 5 MINSLTARIFAIFWLTLALVLMLVLMLPKLDSRQMTELLDSEQRQGLMIEQHIEAELANDPPNDLMWWRRLFRAIDKWAP 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 81 PGQRLLLVTSEGRVIGAERNEMQIIRNFIGQADNADHPQKKRYGRLEMVGPFSVRDGEDNYQLYLIRPANTSQSDFINLL 160
Cdd:PRK09470 85 PGQRLLLVTSEGRIIGAERSEMQAVRNFIGQSDNADHPQKKKYGRVEIVGPFSVRDGEDNYQLYLIRPANSPQSDFINLL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 161 FDRPLLLLIVTMLVSAPLLLWLAWSLAKPARKLKNAADEVAQGNLRQHPELEAGPQEFLAAGTSFNQMVTALERMMSSQH 240
Cdd:PRK09470 165 FDRPLLLLLVTMLVSTPLLLWLAWSLAKPARKLKNAADEVAQGNLRQHPELETGPQEFRQAGASFNQMVTALERMMTSQQ 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 241 RLLSDISHELRTPLTRLQLGTALLRRRSGESKELERIEMEAHRLDSMINDLLVMSRNQAKTALVSETVKANQLWGEVLDN 320
Cdd:PRK09470 245 RLLSDISHELRTPLTRLQLATALLRRRQGESKELERIETEAQRLDSMINDLLVLSRNQQKNHLERETFKANSLWSEVLED 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 321 AAFEAEQMGKSFTVEYPPGPWPLYGNPNALESALENIVRNALRYSHTKISVSFSVDKDGITVNVDDDGPGVSPEDREQIF 400
Cdd:PRK09470 325 AKFEAEQMGKSLTVSAPPGPWPINGNPNALASALENIVRNALRYSHTKIEVAFSVDKDGLTITVDDDGPGVPEEEREQIF 404
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*.
gi 1915344185 401 RPFYRTDEARDRESGGTGLGLAIVEAAIQQHRGWVKADDSPLGGLRLTLWLPLYKR 456
Cdd:PRK09470 405 RPFYRVDEARDRESGGTGLGLAIVENAIQQHRGWVKAEDSPLGGLRLTIWLPLYKR 460
|
|
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
138-455 |
9.06e-69 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 224.05 E-value: 9.06e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 138 EDNYQLYLIRPANTSQSDFINLLFDRPLLLLIVTMLVSAPLLLWLAWSLAKPARKLKNAADEVAQGNLRQHPELEAGPQE 217
Cdd:COG5002 64 LLLALLLLLLLLLLLLALALLLLALLLLLLLLLLLLALLILLLLLALLILLAALLLLLSELLLLLLLLGRLSLRLSALLL 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 218 FLAAGTSFNQMVTALERMMSSQHRLLSDISHELRTPLTRLQLGTALLRRRSGESKE-----LERIEMEAHRLDSMINDLL 292
Cdd:COG5002 144 GLLLLAAVERDITELERLEQMRREFVANVSHELRTPLTSIRGYLELLLDGAADDPEerreyLEIILEEAERLSRLVNDLL 223
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 293 VMSRNQAKT-ALVSETVKANQLWGEVLDNAAFEAEQMGKSFTVEYPPGPWPLYGNPNALESALENIVRNALRYSH--TKI 369
Cdd:COG5002 224 DLSRLESGElKLEKEPVDLAELLEEVVEELRPLAEEKGIELELDLPEDPLLVLGDPDRLEQVLTNLLDNAIKYTPegGTI 303
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 370 SVSFSVDKDGITVNVDDDGPGVSPEDREQIFRPFYRTDEARDRESGGTGLGLAIVEAAIQQHRGWVKADDSPLGGLRLTL 449
Cdd:COG5002 304 TVSLREEDDQVRISVRDTGIGIPEEDLPRIFERFYRVDKSRSRETGGTGLGLAIVKHIVEAHGGRIWVESEPGKGTTFTI 383
|
....*.
gi 1915344185 450 WLPLYK 455
Cdd:COG5002 384 TLPLAR 389
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
142-453 |
3.43e-63 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 207.45 E-value: 3.43e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 142 QLYLIRPANTSQSDFINLLFDRPLLLLIVTMLVSAPLLLWLAWSLAKPARKLKNAADEVAQGNLRQHPELEAGPQEFLAA 221
Cdd:COG0642 13 LLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 222 GTSFNQMVTALERMMSSQHRLLSDISHELRTPLTRLQLGTALLRRRSGE--SKELERIEMEAHRLDSMINDLLVMSRNQA 299
Cdd:COG0642 93 LLLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLELLLEELDEeqREYLETILRSADRLLRLINDLLDLSRLEA 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 300 -KTALVSETVKANQLWGEVLDNAAFEAEQMGKSFTVEYPPGPWPLYGNPNALESALENIVRNALRYSH--TKISVSFSVD 376
Cdd:COG0642 173 gKLELEPEPVDLAELLEEVVELFRPLAEEKGIELELDLPDDLPTVRGDPDRLRQVLLNLLSNAIKYTPegGTVTVSVRRE 252
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1915344185 377 KDGITVNVDDDGPGVSPEDREQIFRPFYRTDEArdRESGGTGLGLAIVEAAIQQHRGWVKADDSPLGGLRLTLWLPL 453
Cdd:COG0642 253 GDRVRISVEDTGPGIPPEDLERIFEPFFRTDPS--RRGGGTGLGLAIVKRIVELHGGTIEVESEPGKGTTFTVTLPL 327
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
226-453 |
1.26e-61 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 200.52 E-value: 1.26e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 226 NQMVTALERMMSSQHRLLSDISHELRTPLTRLQLGTALLRRRSGESKE-----LERIEMEAHRLDSMINDLLVMSRNQA- 299
Cdd:COG2205 3 EEALEELEELERLKSEFLANVSHELRTPLTSILGAAELLLDEEDLSPEerrelLEIIRESAERLLRLIEDLLDLSRLESg 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 300 KTALVSETVKANQLWGEVLDNAAFEAEQMGKSFTVEYPPGPWPLYGNPNALESALENIVRNALRYS--HTKISVSFSVDK 377
Cdd:COG2205 83 KLSLELEPVDLAELLEEAVEELRPLAEEKGIRLELDLPPELPLVYADPELLEQVLANLLDNAIKYSppGGTITISARREG 162
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1915344185 378 DGITVNVDDDGPGVSPEDREQIFRPFYRTDeaRDRESGGTGLGLAIVEAAIQQHRGWVKADDSPLGGLRLTLWLPL 453
Cdd:COG2205 163 DGVRISVSDNGPGIPEEELERIFERFYRGD--NSRGEGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTLPL 236
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
350-453 |
1.12e-58 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 187.92 E-value: 1.12e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 350 LESALENIVRNALRYSHTKISVSFSVDKDGITVNVDDDGPGVSPEDREQIFRPFYRTDEARDRESGGTGLGLAIVEAAIQ 429
Cdd:cd16949 1 LARALENVLRNALRYSPSKILLDISQDGDQWTITITDDGPGVPEDQLEQIFLPFYRVDSARDRESGGTGLGLAIAERAIE 80
|
90 100
....*....|....*....|....
gi 1915344185 430 QHRGWVKADDSPLGGLRLTLWLPL 453
Cdd:cd16949 81 QHGGKIKASNRKPGGLRVRIWLPA 104
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
188-454 |
1.35e-52 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 182.50 E-value: 1.35e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 188 KPARKLKNAADEVAQGNLRQHPELEAGpQEFLAAGTSFNQMVTALERMMSSQHRLLSDISHELRTPLTRLQLGTALLRRR 267
Cdd:PRK10604 162 QDMLKLEAAAQRLGDGHLAERIHFDEG-SSLERLGVAFNQMADNINALIASKKQLIDGIAHELRTPLVRLRYRLEMSDNL 240
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 268 S-GESKELERiemEAHRLDSMINDLLVMSR-NQAKTALVSETVKANQLWGEVLDNaaFEAEQMGKSFTVEYPPGPWPLYG 345
Cdd:PRK10604 241 SaAESQALNR---DIGQLEALIEELLTYARlDRPQNELHLSEPDLPAWLSTHLAD--IQAVTPEKTVRLDTPHQGDYGAL 315
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 346 NPNALESALENIVRNALRYSHTKISVSFSVDKDGITVNVDDDGPGVSPEDREQIFRPFYRTDEARDRESGGTGLGLAIVE 425
Cdd:PRK10604 316 DMRLMERVLDNLLNNALRYAHSRVRVSLLLDGNQACLIVEDDGPGIPPEERERVFEPFVRLDPSRDRATGGCGLGLAIVH 395
|
250 260
....*....|....*....|....*....
gi 1915344185 426 AAIQQHRGWVKADDSPLGGLRLTLWLPLY 454
Cdd:PRK10604 396 SIALAMGGSVNCDESELGGARFSFSWPVW 424
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
188-453 |
3.15e-41 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 151.99 E-value: 3.15e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 188 KPARKLKNAADEVAQGNlrqHPE--LEAGPQEFLAAGTSFNQM---VTALErmmssQHR--LLSDISHELRTPLTRLQLG 260
Cdd:PRK09467 179 RPLVALEHAALQVGKGE---IPPplREYGASEVRSVTRAFNQMaagIKQLE-----DDRtlLMAGVSHDLRTPLTRIRLA 250
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 261 TALLrrrSGESKEL-ERIEMEAHRLDSMINDLLVMSRNQAKtaLVSETVKANQLWGEVldnAAFEAEQmGKSFTVEYPPG 339
Cdd:PRK09467 251 TEMM---SEEDGYLaESINKDIEECNAIIEQFIDYLRTGQE--MPMEMADLNALLGEV---IAAESGY-EREIETALQPG 321
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 340 PWPLYGNPNALESALENIVRNALRYSHTKISVSFSVDKDGITVNVDDDGPGVSPEDREQIFRPFYRTDEARDreSGGTGL 419
Cdd:PRK09467 322 PIEVPMNPIAIKRALANLVVNAARYGNGWIKVSSGTEGKRAWFQVEDDGPGIPPEQLKHLFQPFTRGDSARG--SSGTGL 399
|
250 260 270
....*....|....*....|....*....|....
gi 1915344185 420 GLAIVEAAIQQHRGWVKADDSPLGGLRLTLWLPL 453
Cdd:PRK09467 400 GLAIVKRIVDQHNGKVELGNSEEGGLSARAWLPL 433
|
|
| MtrAB_MtrB |
NF040691 |
MtrAB system histidine kinase MtrB; |
189-449 |
5.88e-39 |
|
MtrAB system histidine kinase MtrB;
Pssm-ID: 468655 [Multi-domain] Cd Length: 507 Bit Score: 147.48 E-value: 5.88e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 189 PARKLKNAADEVAQGNLRQHPElEAGPQEFLAAGTSFNQMVTALERMMSS-------QHRLLSDISHELRTPLTRLQLGT 261
Cdd:NF040691 215 PVRSAARTAERFAAGDLSERMP-VKGEDDLARLARSFNQMADSLQRQIRQleelsrlQQRFVSDVSHELRTPLTTIRMAA 293
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 262 ALLRRRSGE-------SKELERIEMEahRLDSMINDLLVMSRNQAKTA-LVSETVKANQLWGEVLDNAAFEAEQMGKSFT 333
Cdd:NF040691 294 DVIHDSRDDfdpatarSAELLHTELD--RFESLLSDLLEISRFDAGAAeLDVEPVDLRPLVRRVVDALRQLAERAGVELR 371
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 334 VEYPPGPWPLYGNPNALESALENIVRNALRYS-HTKISVSFSVDKDGITVNVDDDGPGVSPEDREQIFRPFYRTDEARDR 412
Cdd:NF040691 372 VDAPGTPVVAEVDPRRVERVLRNLVVNAIEHGeGKPVVVTVAQDDTAVAVTVRDHGVGLKPGEVALVFDRFWRADPARAR 451
|
250 260 270
....*....|....*....|....*....|....*....
gi 1915344185 413 ESGGTGLGLAIVEAAIQQHRGWVKADDSPLGG--LRLTL 449
Cdd:NF040691 452 TTGGTGLGLAIALEDARLHGGWLEAWGRPGQGsqFRLTL 490
|
|
| phoR_proteo |
TIGR02966 |
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory ... |
229-433 |
3.26e-37 |
|
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory histidine kinase PhoR associated with the phosphate ABC transporter in most Proteobacteria. Related proteins from Gram-positive organisms are not included in this model. The phoR gene usually is adjacent to the response regulator phoB gene (TIGR02154). [Signal transduction, Two-component systems]
Pssm-ID: 274368 [Multi-domain] Cd Length: 333 Bit Score: 138.88 E-value: 3.26e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 229 VTALERMMSSQHRLLSDISHELRTPLTRLQ-----LGTALLRRRSGESKELERIEMEAHRLDSMINDLLVMSRNQAKTAL 303
Cdd:TIGR02966 104 VTRLRRLEQMRRDFVANVSHELRTPLTVLRgyletLADGPDEDPEEWNRALEIMLEQSQRMQSLVEDLLTLSRLESAASP 183
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 304 VSET-VKANQLWGEVLDNAAFEAEQMGKSFTVEYPPGPWpLYGNPNALESALENIVRNALRYS--HTKISVSFSVDKDGI 380
Cdd:TIGR02966 184 LEDEpVDMPALLDHLRDEAEALSQGKNHQITFEIDGGVD-VLGDEDELRSAFSNLVSNAIKYTpeGGTITVRWRRDGGGA 262
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 1915344185 381 TVNVDDDGPGVSPEDREQIFRPFYRTDEARDRESGGTGLGLAIVEAAIQQHRG 433
Cdd:TIGR02966 263 EFSVTDTGIGIAPEHLPRLTERFYRVDKSRSRDTGGTGLGLAIVKHVLSRHHA 315
|
|
| BaeS_SmeS |
NF012163 |
sensor histidine kinase efflux regulator BaeS; |
169-452 |
1.14e-36 |
|
sensor histidine kinase efflux regulator BaeS;
Pssm-ID: 411086 [Multi-domain] Cd Length: 457 Bit Score: 139.96 E-value: 1.14e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 169 IVTMLVSAPLLLWLAWSLAKPARKLKNAADEVAQGNLrQHPELEAGPQEFLAAGTSFNQMVTALERMMSSQHRLLSDISH 248
Cdd:NF012163 171 ALALLLAALAAFLLARGLLAPVKRLVEATHRLAAGDY-TTRVTPTSNDELGKLAQDFNQLASTLEKNEQMRRDFMADISH 249
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 249 ELRTPLTRLQLGTALLRR--RSGESKELERIEMEAHRLDSMINDL--LVMSRNQAkTALVSETVKANQLWGEVLDNAAFE 324
Cdd:NF012163 250 ELRTPLAVLRAELEAIQDgiRKFTPESLDSLQAEVGTLTKLVDDLhdLSMSDEGA-LAYQKASVDLVPLLEVEGGAFRER 328
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 325 AEQMGKSFTVEYPPGPWpLYGNPNALESALENIVRNALRYSHT--KISVSFSVDKDGITVNVDDDGPGVSPEDREQIFRP 402
Cdd:NF012163 329 FASAGLELEVSLPDSSL-VFGDRDRLMQLFNNLLENSLRYTDSggSLHISASQRPKEVTLTVADSAPGVSDEQLARLFER 407
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 1915344185 403 FYRTDEARDRESGGTGLGLAIVEAAIQQHRGWVKADDSPLGGLRLTLWLP 452
Cdd:NF012163 408 FYRVEVSRNRASGGSGLGLAISLNIVQAHGGTLHAAHSPLGGLRIVVTLP 457
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
229-453 |
2.24e-36 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 138.56 E-value: 2.24e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 229 VTALERM--MSSQHRLLSDISHELRTPLTRLQLGTALLRRRSGESKE---------LERIEMEAHRLDSMINDLLVMSRn 297
Cdd:COG5000 189 ITELLRAerLAAWGELARRIAHEIKNPLTPIQLSAERLRRKLADKLEedredleraLDTIIRQVDRLKRIVDEFLDFAR- 267
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 298 qaKTALVSETVKANQLWGEVLDNAAFEAEQMGKSFTVEYPPGPWPLYGNPNALESALENIVRNALR--YSHTKISVSFSV 375
Cdd:COG5000 268 --LPEPQLEPVDLNELLREVLALYEPALKEKDIRLELDLDPDLPEVLADRDQLEQVLINLLKNAIEaiEEGGEIEVSTRR 345
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1915344185 376 DKDGITVNVDDDGPGVSPEDREQIFRPFYRTDEardresGGTGLGLAIVEAAIQQHRGWVKADDSPLGGLRLTLWLPL 453
Cdd:COG5000 346 EDGRVRIEVSDNGPGIPEEVLERIFEPFFTTKP------KGTGLGLAIVKKIVEEHGGTIELESRPGGGTTFTIRLPL 417
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
350-453 |
7.80e-36 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 127.93 E-value: 7.80e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 350 LESALENIVRNALRYSHTKISVSFSVDKDGITVNVDDDGPGVSPEDREQIFRPFYRTDEARDRESGGTGLGLAIVEAAIQ 429
Cdd:cd16939 1 MARALDNLLRNALRYAHRTVRIALLVSGGRLTLIVEDDGPGIPAAARERVFEPFVRLDPSRDRATGGFGLGLAIVHRVAL 80
|
90 100
....*....|....*....|....
gi 1915344185 430 QHRGWVKADDSPLGGLRLTLWLPL 453
Cdd:cd16939 81 WHGGHVECDDSELGGACFRLTWPR 104
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
246-452 |
1.65e-35 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 137.61 E-value: 1.65e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 246 ISHELRTPLTRLQLGTALLRRRSGES------KELERIEMEAHRLDSMINDLLVMSRnQAKTALVSETVKANQLWGEVLD 319
Cdd:COG4251 289 ASHDLREPLRKISGFSQLLEEDYGDKldeegrEYLERIRDAAERMQALIDDLLAYSR-VGRQELEFEPVDLNELLEEVLE 367
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 320 NAAFEAEQmgKSFTVEYPPGPwPLYGNPNALESALENIVRNALRYSHT----KISVSFSVDKDGITVNVDDDGPGVSPED 395
Cdd:COG4251 368 DLEPRIEE--RGAEIEVGPLP-TVRGDPTLLRQVFQNLISNAIKYSRPgeppRIEIGAEREGGEWVFSVRDNGIGIDPEY 444
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 1915344185 396 REQIFRPFYRTDEARDREsgGTGLGLAIVEAAIQQHRGWVKADDSPLGGLRLTLWLP 452
Cdd:COG4251 445 AEKIFEIFQRLHSRDEYE--GTGIGLAIVKKIVERHGGRIWVESEPGEGATFYFTLP 499
|
|
| cztS_silS_copS |
TIGR01386 |
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
36-452 |
3.41e-35 |
|
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.
Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 135.98 E-value: 3.41e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 36 TELLESEQRQGIMieQHVEAELANDPPNDLMWwRRLFRAIDKW--APPGQRLLLVTSEGRVIGAERNEMQIIRNFIGQA- 112
Cdd:TIGR01386 35 FEERDREELQGKL--EQVRRFLRDPADLDEDI-KRLQEKIDDLlvGHSDLALSILNPDGRLLFERAQGAALVPAVAANDa 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 113 ----DNADHPQKKRYGRLEMVGPFSVRDGEDNYQLYLIRPANTSQSdFINLLFDRPLLLLIVTMLVSAPLLLWLAWSLAK 188
Cdd:TIGR01386 112 llelDQADAKMTHYRSILRSVAALPGGKGRKPVQITVALDINAHTH-LLDALRKWLILIAVLLVLLTALLGWWITRLGLE 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 189 PARKLKNAADEVAQGNLRQHPELEAGPQEFLAAGTSFNQMVTALERMMSSQHRLLSDISHELRTPLTRL--QLGTALLRR 266
Cdd:TIGR01386 191 PLRRLSAVAARISPESLDQRLDPSRAPAELRELAQSFNAMLGRLEDAFQRLSQFSADLAHELRTPLTNLlgQTQVALSQP 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 267 RSGESKE--LERIEMEAHRLDSMINDLLVMSR-NQAKTALVSETVKANQLWGEVLDNAAFEAEQMGKSFTVEyppGPWPL 343
Cdd:TIGR01386 271 RTGEEYRevLESNLEELERLSRMVSDMLFLARaDNGQLALERVRLDLAAELAKVAEYFEPLAEERGVRIRVE---GEGLV 347
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 344 YGNPNALESALENIVRNALRYS--HTKISVSFSVDKDGITVNVDDDGPGVSPEDREQIFRPFYRTDEARDRESGGTGLGL 421
Cdd:TIGR01386 348 RGDPQMFRRAISNLLSNALRHTpdGGTITVRIERRSDEVRVSVSNPGPGIPPEHLSRLFDRFYRVDPARSNSGEGTGLGL 427
|
410 420 430
....*....|....*....|....*....|.
gi 1915344185 422 AIVEAAIQQHRGWVKAdDSPLGGLRLTLWLP 452
Cdd:TIGR01386 428 AIVRSIMEAHGGRASA-ESPDGKTRFILRFP 457
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
241-453 |
1.62e-34 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 132.23 E-value: 1.62e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 241 RLLSDISHELRTPLTRLQLGTALLRRRSGESKE-------LERIEMEAHRLDSMINDLLVMSRnqaKTALVSETVKANQL 313
Cdd:COG4191 144 ELAAGIAHEINNPLAAILGNAELLRRRLEDEPDpeelreaLERILEGAERAAEIVRSLRAFSR---RDEEEREPVDLNEL 220
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 314 WGEVLDNAAFEAEQMGKSFTVEYPPGPWPLYGNPNALESALENIVRNAL----RYSHTKISVSFSVDKDGITVNVDDDGP 389
Cdd:COG4191 221 IDEALELLRPRLKARGIEVELDLPPDLPPVLGDPGQLEQVLLNLLINAIdameEGEGGRITISTRREGDYVVISVRDNGP 300
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1915344185 390 GVSPEDREQIFRPFYRTDEardrESGGTGLGLAIVEAAIQQHRGWVKADDSPLGGLRLTLWLPL 453
Cdd:COG4191 301 GIPPEVLERIFEPFFTTKP----VGKGTGLGLSISYGIVEKHGGRIEVESEPGGGTTFTITLPL 360
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
225-455 |
2.48e-34 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 133.60 E-value: 2.48e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 225 FNQMVTALERMMSSQHRLLSDISHELRTPLT-------RLQLGtalLRRRSGESkeLERIEMEAHRLDSMINDL--LVMS 295
Cdd:PRK10549 226 FNQLASTLEKNEQMRRDFMADISHELRTPLAvlrgeleAIQDG---VRKFTPES--VASLQAEVGTLTKLVDDLhqLSLS 300
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 296 RNQAkTALVSETVKANQLWGEVLdnAAFEAEQMGKSFTVEYP-PGPWPLYGNPNALESALENIVRNALRY--SHTKISVS 372
Cdd:PRK10549 301 DEGA-LAYRKTPVDLVPLLEVAG--GAFRERFASRGLTLQLSlPDSATVFGDPDRLMQLFNNLLENSLRYtdSGGSLHIS 377
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 373 FSVDKDGITVNVDDDGPGVSPEDREQIFRPFYRTDEARDRESGGTGLGLAIVEAAIQQHRGWVKADDSPLGGLRLTLWLP 452
Cdd:PRK10549 378 AEQRDKTLRLTFADSAPGVSDEQLQKLFERFYRTEGSRNRASGGSGLGLAICLNIVEAHNGRIIAAHSPFGGVSITVELP 457
|
...
gi 1915344185 453 LYK 455
Cdd:PRK10549 458 LER 460
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
232-457 |
6.80e-34 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 130.35 E-value: 6.80e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 232 LERMMSSQHRLLS------DISHELRTPLTRLQLGTALLRRRSGESKELERIEM---EAHRLDSMINDLLVMSRNQAkta 302
Cdd:COG3852 122 LERELRRAEKLAAvgelaaGLAHEIRNPLTGIRGAAQLLERELPDDELREYTQLiieEADRLNNLVDRLLSFSRPRP--- 198
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 303 LVSETVKANQLWGEVLDNAAFEAEQmGKSFTVEYPPGPWPLYGNPNALESALENIVRNAL-------------RYSHtKI 369
Cdd:COG3852 199 PEREPVNLHEVLERVLELLRAEAPK-NIRIVRDYDPSLPEVLGDPDQLIQVLLNLVRNAAeampeggtitirtRVER-QV 276
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 370 SVSFSVDKDGITVNVDDDGPGVSPEDREQIFRPFYRTDEardresGGTGLGLAIVEAAIQQHRGWVKADDSPLGGLRLTL 449
Cdd:COG3852 277 TLGGLRPRLYVRIEVIDNGPGIPEEILDRIFEPFFTTKE------KGTGLGLAIVQKIVEQHGGTIEVESEPGKGTTFRI 350
|
....*...
gi 1915344185 450 WLPLYKRT 457
Cdd:COG3852 351 YLPLEQAE 358
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
345-453 |
3.25e-32 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 118.52 E-value: 3.25e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 345 GNPNALESALENIVRNALRYSH--TKISVSFSVDKDGITVNVDDDGPGVSPEDREQIFRPFYRTDEaRDRESGGTGLGLA 422
Cdd:smart00387 1 GDPDRLRQVLSNLLDNAIKYTPegGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDK-RSRKIGGTGLGLS 79
|
90 100 110
....*....|....*....|....*....|.
gi 1915344185 423 IVEAAIQQHRGWVKADDSPLGGLRLTLWLPL 453
Cdd:smart00387 80 IVKKLVELHGGEISVESEPGGGTTFTITLPL 110
|
|
| HATPase |
cd00075 |
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ... |
350-451 |
9.94e-31 |
|
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.
Pssm-ID: 340391 [Multi-domain] Cd Length: 102 Bit Score: 114.24 E-value: 9.94e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 350 LESALENIVRNALRYS--HTKISVSFSVDKDGITVNVDDDGPGVSPEDREQIFRPFYRTDEArdRESGGTGLGLAIVEAA 427
Cdd:cd00075 1 LEQVLSNLLDNALKYSppGGTIEISLRQEGDGVVLEVEDNGPGIPEEDLERIFERFYRGDKS--REGGGTGLGLAIVRRI 78
|
90 100
....*....|....*....|....
gi 1915344185 428 IQQHRGWVKADDSPLGGLRLTLWL 451
Cdd:cd00075 79 VEAHGGRITVESEPGGGTTFTVTL 102
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
346-452 |
5.20e-28 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 107.16 E-value: 5.20e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 346 NPNALESALENIVRNALRYSHT--KISVSFSVDKDGITVNVDDDGPGVSPEDREQIFRPFYRTDEARDRESGGTGLGLAI 423
Cdd:cd16946 1 DRDRLQQLFVNLLENSLRYTDTggKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVESSRNRASGGSGLGLAI 80
|
90 100
....*....|....*....|....*....
gi 1915344185 424 VEAAIQQHRGWVKADDSPLGGLRLTLWLP 452
Cdd:cd16946 81 CHNIALAHGGTISAEHSPLGGLRLVLTLP 109
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
229-452 |
5.12e-27 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 112.41 E-value: 5.12e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 229 VTALERMMSSQHRLLSDISHELRTPLTRLQLGTALLRRRSGES----KELERIEMEAHRLDSMINDLLVMSRNQAKTALV 304
Cdd:PRK11006 194 VTQMHQLEGARRNFFANVSHELRTPLTVLQGYLEMMQDQPLEGalreKALHTMREQTQRMEGLVKQLLTLSKIEAAPTID 273
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 305 SETVKANQLWGEVLDNAAFEAEQMGKSFTVEYPPGpWPLYGNPNALESALENIVRNALRYS--HTKISVSFSVDKDGITV 382
Cdd:PRK11006 274 LNEKVDVPMMLRVLEREAQTLSQGKHTITFEVDNS-LKVFGNEDQLRSAISNLVYNAVNHTpeGTHITVRWQRVPQGAEF 352
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 383 NVDDDGPGVSPEDREQIFRPFYRTDEARDRESGGTGLGLAIVEAAIQQHRGWVKADDSPLGGLRLTLWLP 452
Cdd:PRK11006 353 SVEDNGPGIAPEHIPRLTERFYRVDKARSRQTGGSGLGLAIVKHALSHHDSRLEIESEVGKGTRFSFVLP 422
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
188-452 |
5.17e-27 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 112.94 E-value: 5.17e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 188 KPARKLKNAADEVAQGNLRQHPELEAGPQEFLAAGTSFNQMVTALERMMSSQHRLLSDISHELRTPLTRL--QLGTALLR 265
Cdd:PRK09835 211 APIRSVSRQIQNITSKDLDVRLDPQTVPIELEQLVLSFNHMIERIEDVFTRQSNFSADIAHEIRTPITNLitQTEIALSQ 290
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 266 RRSgeSKELERIEM----EAHRLDSMINDLLVMSrnQAKTALVSETVKANQLWGEVLDNAAF-EAEQMGKSFTVEYPPGP 340
Cdd:PRK09835 291 SRS--QKELEDVLYsnleELTRMAKMVSDMLFLA--QADNNQLIPEKKMLDLADEVGKVFDFfEAWAEERGVELRFVGDP 366
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 341 WPLYGNPNALESALENIVRNALRYSHT--KISVSFSVDKDGITVNVDDDGPGVSPEDREQIFRPFYRTDEARDRESGGTG 418
Cdd:PRK09835 367 CQVAGDPLMLRRAISNLLSNALRYTPAgeAITVRCQEVDHQVQLVVENPGTPIAPEHLPRLFDRFYRVDPSRQRKGEGSG 446
|
250 260 270
....*....|....*....|....*....|....*.
gi 1915344185 419 LGLAIVEAAIQQHRG--WVKADdspLGGLRLTLWLP 452
Cdd:PRK09835 447 IGLAIVKSIVVAHKGtvAVTSD---ARGTRFVISLP 479
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
345-453 |
1.21e-26 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 103.22 E-value: 1.21e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 345 GNPNALESALENIVRNALRYSH--TKISVSFSvDKDGITVNVDDDGPGVSPEDREQIFRPFYRTDearDRESGGTGLGLA 422
Cdd:pfam02518 1 GDELRLRQVLSNLLDNALKHAAkaGEITVTLS-EGGELTLTVEDNGIGIPPEDLPRIFEPFSTAD---KRGGGGTGLGLS 76
|
90 100 110
....*....|....*....|....*....|.
gi 1915344185 423 IVEAAIQQHRGWVKADDSPLGGLRLTLWLPL 453
Cdd:pfam02518 77 IVRKLVELLGGTITVESEPGGGTTVTLTLPL 107
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
189-453 |
9.68e-25 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 106.47 E-value: 9.68e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 189 PARKLKNAADEVAQGNLRQHPELeaGPQEFLAAGTSFNQMVTALErmmSSQH--RLLSDISHELRTPLTRLqLGTALLRR 266
Cdd:PRK11100 209 SIRRLTRYADAVTEGKPVPLPKL--GSSELRELAQALESMRVKLE---GKAYveQYVQTLTHELKSPLAAI-RGAAELLQ 282
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 267 RSGESKELER----IEMEAHRLDSMINDLLVMSRNQAKTAL-VSETVKANQLWGEVLDNAAFEAEQmgKSFTVEYPPGPW 341
Cdd:PRK11100 283 EDPPPEDRARftgnILTQSARLQQLIDRLLELARLEQRQELeVLEPVALAALLEELVEAREAQAAA--KGITLRLRPDDA 360
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 342 PLYGNPNALESALENIVRNALRYSHTK--ISVSFSVDKDGITVNVDDDGPGVSPEDREQIFRPFY---RTDEARDresgG 416
Cdd:PRK11100 361 RVLGDPFLLRQALGNLLDNAIDFSPEGgtITLSAEVDGEQVALSVEDQGPGIPDYALPRIFERFYslpRPANGRK----S 436
|
250 260 270
....*....|....*....|....*....|....*..
gi 1915344185 417 TGLGLAIVEAAIQQHRGWVKADDSPLGGLRLTLWLPL 453
Cdd:PRK11100 437 TGLGLAFVREVARLHGGEVTLRNRPEGGVLATLTLPR 473
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
350-452 |
1.17e-24 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 97.52 E-value: 1.17e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 350 LESALENIVRNALRYSHTKISVSFSVDKDGITVNVDDDGPGVSPEDREQIFRPFYRTDEARDreSGGTGLGLAIVEAAIQ 429
Cdd:cd16950 1 LKRVLSNLVDNALRYGGGWVEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYRGDNARG--TSGTGLGLAIVQRISD 78
|
90 100
....*....|....*....|...
gi 1915344185 430 QHRGWVKADDSPLGGLRLTLWLP 452
Cdd:cd16950 79 AHGGSLTLANRAGGGLCARIELP 101
|
|
| AdeS_HK |
NF012226 |
two-component sensor histidine kinase AdeS; Mutations in this component of the two-component ... |
188-433 |
7.98e-24 |
|
two-component sensor histidine kinase AdeS; Mutations in this component of the two-component regulatory system for the AdeABC efflux pump can confer adaptive resistance to certain antibiotics, including tigecycline.
Pssm-ID: 411090 [Multi-domain] Cd Length: 353 Bit Score: 102.00 E-value: 7.98e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 188 KPARKLKNAADEVAQGNLRQHPELEAG-PQEFLAAGTSFNQMVTALERMMSSQHRLLSDISHELRTPLT----RLQ---- 258
Cdd:NF012226 86 VPINFLADAAKKISQGDLSARAEDSQIhSAEISELMHNFNDMAQKLESSVKNAQVWNAAIAHELRTPITilqgRLQgild 165
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 259 --------LGTALLRRRSGeskeleriemeahrLDSMINDLLVMS--RNQaKTALVSETVKANQLWGEVLDnaAFEAEQM 328
Cdd:NF012226 166 gvfepdpaLFKSLLNQVEG--------------LSHLVEDLRTLSlvENQ-QLRLNYESVDLKDSIEKVLK--MFEDRLE 228
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 329 GKSFTVEYPPGPWPLYGNPNALESALENIVRNALRYSHT-KISVSFSVDKDGITVNVDDDGPGVSPEDREQIFRPFYRTD 407
Cdd:NF012226 229 QAQLTIVLNLTATPVFCDRRRIEQVLIALIDNAIRYANAgKLKISSSVIQDDWILQIEDEGPGIAEEYQQDLFNPFFRLE 308
|
250 260
....*....|....*....|....*.
gi 1915344185 408 EARDRESGGTGLGLAIVEAAIQQHRG 433
Cdd:NF012226 309 QSRNKEFGGTGLGLAVVHAIVIAHKG 334
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
216-452 |
1.43e-23 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 101.20 E-value: 1.43e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 216 QEFLAAGTSFNQMVTALERMMSsQHRLL-SDISHELRTPLTRLQLGTALLRRRSG-ESKELerIEmeahRLDSM---IND 290
Cdd:PRK10755 114 LEIEAVTSALNQLVSRLTSTLD-QERLFtADVAHELRTPLAGIRLHLELLEKQHHiDVAPL--IA----RLDQMmhtVEQ 186
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 291 LLVMSR--------NQAKTALVSETVKANQlwgevlDNAAFEAEQMGKSFTVEYPPGPWPLYGNPNALESALENIVRNAL 362
Cdd:PRK10755 187 LLQLARagqsfssgHYQTVKLLEDVILPSQ------DELSEMLEQRQQTLLLPESAADITVQGDATLLRLLLRNLVENAH 260
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 363 RYS--HTKISVSFSVDKDGITVNVDDDGPGVSPEDREQIFRPFYRTdearDRESGGTGLGLAIVEAAIQQHRGWVKADD- 439
Cdd:PRK10755 261 RYSpeGSTITIKLSQEDGGAVLAVEDEGPGIDESKCGELSKAFVRM----DSRYGGIGLGLSIVSRITQLHHGQFFLQNr 336
|
250
....*....|...
gi 1915344185 440 SPLGGLRLTLWLP 452
Cdd:PRK10755 337 QERSGTRAWVWLP 349
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
329-446 |
5.44e-23 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 94.24 E-value: 5.44e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 329 GKSFTVEYPPG-PWPlyGNPNALESALENIVRNALRYSHTKISVSFSVDKDGITVNVDDDGPGVSPEDREQIFRPFYRTD 407
Cdd:cd16954 18 GVSISLDISPElRFP--GERNDLMELLGNLLDNACKWCLEFVEVTARQTDGGLHLIVDDDGPGVPESQRSKIFQRGQRLD 95
|
90 100 110
....*....|....*....|....*....|....*....
gi 1915344185 408 EARDresgGTGLGLAIVEAAIQQHRGWVKADDSPLGGLR 446
Cdd:cd16954 96 EQRP----GQGLGLAIAKEIVEQYGGELSLSDSPLGGAR 130
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
232-433 |
8.58e-21 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 94.66 E-value: 8.58e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 232 LERMMSSQHRL------LSDISHELRTPLTRL----QLgtaLLRRRSGESKE-LERIEMEAHRLDSMINDLLVMSRNQAK 300
Cdd:COG5809 257 LEELLRKSEKLsvvgelAAGIAHEIRNPLTSLkgfiQL---LKDTIDEEQKTyLDIMLSELDRIESIISEFLVLAKPQAI 333
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 301 TAlvsETVKANQLWGEVLDnaAFEAEQMGKSFTVEY-PPGPWP-LYGNPNALESALENIVRNALRY--SHTKISVS-FSV 375
Cdd:COG5809 334 KY---EPKDLNTLIEEVIP--LLQPQALLKNVQIELeLEDDIPdILGDENQLKQVFINLLKNAIEAmpEGGNITIEtKAE 408
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 1915344185 376 DKDGITVNVDDDGPGVSPEDREQIFRPFYRTDEardresGGTGLGLAIVEAAIQQHRG 433
Cdd:COG5809 409 DDDKVVISVTDEGCGIPEERLKKLGEPFYTTKE------KGTGLGLMVSYKIIEEHGG 460
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
215-449 |
9.59e-21 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 94.33 E-value: 9.59e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 215 PQEFLAAGTSFNQMVTALERMMSSQHRLLSDISHELRTPLTRLQLGT--ALLRRRSGESKE--LERIEMEAHRLDSMIND 290
Cdd:PRK10337 213 PSEVRPLVEALNQLFARTHAMMVRERRFTSDAAHELRSPLAALKVQTevAQLSDDDPQARKkaLLQLHAGIDRATRLVDQ 292
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 291 LLVMSRNQAKTALvsETVKANQlWGEVLDNAAFE----AEQMGKSFTVEYPPGPWPLYGNPNALESALENIVRNALRYSH 366
Cdd:PRK10337 293 LLTLSRLDSLDNL--QDVAEIP-LEDLLQSAVMDiyhtAQQAGIDVRLTLNAHPVIRTGQPLLLSLLVRNLLDNAIRYSP 369
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 367 TKISVSFSVDKDGITVNvdDDGPGVSPEDREQIFRPFYRTDearDRESGGTGLGLAIVEAAIQQHRGWVKADDSPLGGLR 446
Cdd:PRK10337 370 QGSVVDVTLNARNFTVR--DNGPGVTPEALARIGERFYRPP---GQEATGSGLGLSIVRRIAKLHGMNVSFGNAPEGGFE 444
|
...
gi 1915344185 447 LTL 449
Cdd:PRK10337 445 AKV 447
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
203-453 |
2.23e-20 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 94.33 E-value: 2.23e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 203 GNLRQH--PEleagPQEFLaagTSFNQMVT-ALERMMSSQ---------------HRLLSDISHELRTPLTRL--QLGTA 262
Cdd:PRK10490 617 GNLRQLmiPE----QQRLL---ETFTLLIAnALERLTLTAseeqarlasereqlrNALLAALSHDLRTPLTVLfgQAEIL 689
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 263 LLRRRSGESKELERI-EMEAHRLDS--MINDLLVMSRNQaktalvSETVKANQLWgEVLDNAAFEAEQM------GKSFT 333
Cdd:PRK10490 690 TLDLASEGSPHARQAsEIRQQVLNTtrLVNNLLDMARIQ------SGGFNLRKEW-LTLEEVVGSALQMlepglsGHPIN 762
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 334 VEYPPGPWPLYGNPNALESALENIVRNALRY--SHTKISVSFSVDKDGITVNVDDDGPGVSPEDREQIFRPFYRTDeard 411
Cdd:PRK10490 763 LSLPEPLTLIHVDGPLFERVLINLLENAVKYagAQAEIGIDAHVEGERLQLDVWDNGPGIPPGQEQLIFDKFARGN---- 838
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 1915344185 412 RESG--GTGLGLAIVEAAIQQHRGWVKADDSPLGGLRLTLWLPL 453
Cdd:PRK10490 839 KESAipGVGLGLAICRAIVEVHGGTIWAENRPEGGACFRVTLPL 882
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
229-453 |
5.16e-20 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 92.72 E-value: 5.16e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 229 VTALERMMSSQHR---------LLSDISHELRTPLTRLQLGTALLRR---RSGESKELERIEMEAHRLDSMINDLLVMSR 296
Cdd:PRK11360 371 LTERKRLQRRVARqerlaalgeLVAGVAHEIRNPLTAIRGYVQIWRQqtsDPPSQEYLSVVLREVDRLNKVIDQLLEFSR 450
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 297 -NQAKTALVSetvkANQLWGEVLDNAAFEAEQMGKSFTVEYPPGPWPLYGNPNALESALENIVRNALRYSHT--KISVSF 373
Cdd:PRK11360 451 pRESQWQPVS----LNALVEEVLQLFQTAGVQARVDFETELDNELPPIWADPELLKQVLLNILINAVQAISArgKIRIRT 526
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 374 SVDKDG-ITVNVDDDGPGVSPEDREQIFRPFYRTdeardrESGGTGLGLAIVEAAIQQHRGWVKADDSPLGGLRLTLWLP 452
Cdd:PRK11360 527 WQYSDGqVAVSIEDNGCGIDPELLKKIFDPFFTT------KAKGTGLGLALSQRIINAHGGDIEVESEPGVGTTFTLYLP 600
|
.
gi 1915344185 453 L 453
Cdd:PRK11360 601 I 601
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
232-453 |
1.31e-19 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 91.00 E-value: 1.31e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 232 LERMMSSQHRLLS------DISHELRTPLTRLQ-LGTALLRR--RSGESKELERIEM-EAHRLDSMINDLLVMSRnqaKT 301
Cdd:PRK10364 224 LQDEMKRKEKLVAlghlaaGVAHEIRNPLSSIKgLAKYFAERapAGGEAHQLAQVMAkEADRLNRVVSELLELVK---PT 300
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 302 ALVSETVKANQLWGEVLDNAAFEAEQMGKSFTVEYPPGPWPLYGNPNALESALENIVRNALRY--SHTKISVSFSVDKDG 379
Cdd:PRK10364 301 HLALQAVDLNDLINHSLQLVSQDANSREIQLRFTANDTLPEIQADPDRLTQVLLNLYLNAIQAigQHGVISVTASESGAG 380
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1915344185 380 ITVNVDDDGPGVSPEDREQIFRPFYRTdeardrESGGTGLGLAIVEAAIQQHRGWVKADDSPLGGLRLTLWLPL 453
Cdd:PRK10364 381 VKISVTDSGKGIAADQLEAIFTPYFTT------KAEGTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTLWLPV 448
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
345-451 |
4.87e-19 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 82.45 E-value: 4.87e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 345 GNPNALESALENIVRNALRYS--HTKISVSFSVDkDGITVNVDDDGPGVSPEDREQIFRPFYRTDEardRESGGTGLGLA 422
Cdd:cd16940 9 GDALLLFLLLRNLVDNAVRYSpqGSRVEIKLSAD-DGAVIRVEDNGPGIDEEELEALFERFYRSDG---QNYGGSGLGLS 84
|
90 100
....*....|....*....|....*....
gi 1915344185 423 IVEAAIQQHRGWVKADDSPLGGLRLTLWL 451
Cdd:cd16940 85 IVKRIVELHGGQIFLGNAQGGGLEAWVRL 113
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
236-453 |
5.19e-19 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 88.37 E-value: 5.19e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 236 MSSQHRLLSDISHELRTpltRLQLGTALLRrrSGESKELER-IEMEAHRLDSMINDLLVMSRNQAKTALVSEtvKANqlw 314
Cdd:COG3290 186 VKELAEALRAQRHDFRN---HLHTISGLLQ--LGEYDEALEyIDEISEELQELIDSLLSRIGNPVLAALLLG--KAA--- 255
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 315 gevldnaafEAEQMGKSFTVEYPPGPWPLYGNPNALESALENIVRNALRY------SHTKISVSFSVDKDGITVNVDDDG 388
Cdd:COG3290 256 ---------RARERGIDLTIDIDSDLPDLPLSDTDLVTILGNLLDNAIEAveklpeEERRVELSIRDDGDELVIEVEDSG 326
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1915344185 389 PGVSPEDREQIFRPFYRTdeardRESGGTGLGLAIVEAAIQQHRGWVKADDSPLGGLRLTLWLPL 453
Cdd:COG3290 327 PGIPEELLEKIFERGFST-----KLGEGRGLGLALVKQIVEKYGGTIEVESEEGEGTVFTVRLPK 386
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
350-452 |
5.24e-19 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 82.25 E-value: 5.24e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 350 LESALENIVRNALRYS--HTKISVSFSVDKDGITVNVDDDGPGVSPEDREQIFRPFYRTDEARDRESGGTGLGLAIVEAA 427
Cdd:cd16952 1 LRSAFSNLVSNAVKYTppSDTITVRWSQEESGARLSVEDTGPGIPPEHIPRLTERFYRVDIERCRNTGGTGLGLAIVKHV 80
|
90 100
....*....|....*....|....*
gi 1915344185 428 IQQHRGWVKADDSPLGGLRLTLWLP 452
Cdd:cd16952 81 MSRHDARLLIASELGKGSRFTCLFP 105
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
346-450 |
4.31e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 76.73 E-value: 4.31e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 346 NPNALESALENIVRNALRYSHTKISVSFSV--DKDGITVNVDDDGPGVSPEDREQIFRPFYRTDEARDreSGG-TGLGLA 422
Cdd:cd16975 1 DTLLLSRALINIISNACQYAPEGGTVSISIydEEEYLYFEIWDNGHGFSEQDLKKALELFYRDDTSRR--SGGhYGMGLY 78
|
90 100
....*....|....*....|....*...
gi 1915344185 423 IVEAAIQQHRGWVKADDSPLGGLRLTLW 450
Cdd:cd16975 79 IAKNLVEKHGGSLIIENSQKGGAEVTVK 106
|
|
| PRK10815 |
PRK10815 |
two-component system sensor histidine kinase PhoQ; |
206-447 |
6.37e-17 |
|
two-component system sensor histidine kinase PhoQ;
Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 82.76 E-value: 6.37e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 206 RQHPELEAGPQEFLAAGTS--FNQMVTALERMMSSQHR-------LLSDISHELRTPLTRLQlgTALLRRRSG-----ES 271
Cdd:PRK10815 224 KQVRELEEGEREQLDPNPPreLTSLVRNLNRLLKNERErytkyrtTLTDLTHSLKTPLAVLQ--STLRSLRSGkqmsvEQ 301
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 272 KE---LERIEMEA-------HRLdSMINDLLVMSRNQAKTA--LVSETVKANQLWgevldnaafeaEQMGKSFTVEYPPg 339
Cdd:PRK10815 302 AEpimLEQISRISqqigyylHRA-SMRSEHNLLSRELHSVAplLDNLTSALNKVY-----------QRKGVNITLDISP- 368
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 340 PWPLYGNPNALESALENIVRNALRYSHTKISVSFSVDKDGITVNVDDDGPGVSPEDREQIFRPFYRTDEARDresgGTGL 419
Cdd:PRK10815 369 EITFVGEKNDFMEVMGNVLDNACKYCLEFVEISARQTDEHLHIVVEDDGPGIPESKRELIFDRGQRADTLRP----GQGL 444
|
250 260
....*....|....*....|....*...
gi 1915344185 420 GLAIVEAAIQQHRGWVKADDSPLGGLRL 447
Cdd:PRK10815 445 GLSVAREITEQYEGKISAGDSPLGGARM 472
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
346-452 |
9.35e-17 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 75.99 E-value: 9.35e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 346 NPNALESALENIVRNALRYSHT--KISVSFSV-DKDGITVNVDDDGPGVSPEDREQIFRPFYRTDEARDRESGGTGLGLA 422
Cdd:cd16925 1 DAEKYERVVLNLLSNAFKFTPDggRIRCILEKfRLNRFLLTVSDSGPGIPPNLREEIFERFRQGDGSSTRAHGGTGLGLS 80
|
90 100 110
....*....|....*....|....*....|
gi 1915344185 423 IVEAAIQQHRGWVKADDSPLGGLRLTLWLP 452
Cdd:cd16925 81 IVKEFVELHGGTVTVSDAPGGGALFQVELP 110
|
|
| TMAO_torS |
TIGR02956 |
TMAO reductase sytem sensor TorS; This protein, TorS, is part of a regulatory system for the ... |
243-426 |
1.07e-15 |
|
TMAO reductase sytem sensor TorS; This protein, TorS, is part of a regulatory system for the torCAD operon that encodes the pterin molybdenum cofactor-containing enzyme trimethylamine-N-oxide (TMAO) reductase (TorA), a cognate chaperone (TorD), and a penta-haem cytochrome (TorC). TorS works together with the inducer-binding protein TorT and the response regulator TorR. TorS contains histidine kinase ATPase (pfam02518), HAMP (pfam00672), phosphoacceptor (pfam00512), and phosphotransfer (pfam01627) domains and a response regulator receiver domain (pfam00072). [Signal transduction, Two-component systems]
Pssm-ID: 274362 [Multi-domain] Cd Length: 968 Bit Score: 79.82 E-value: 1.07e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 243 LSDISHELRTPLTRLqLGTALLRRRSG----ESKELERIEMEAHRLDSMINDLLVMSRNQAKTALVSET-VKANQLWGEV 317
Cdd:TIGR02956 468 LATMSHEIRTPLNGI-LGTLELLGDTGltsqQQQYLQVINRSGESLLDILNDILDYSKIEAGHLSISPRpFDLNALLDDV 546
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 318 LDNAAFEAEQMGKSFTVEYPPG-PWPLYGNPNALESALENIVRNALRYSHT-KISVSFSVDKDG-ITVNVDDDGPGVSPE 394
Cdd:TIGR02956 547 HHLMVSRAQLKGIQLRLNIPEQlPNWWQGDGPRIRQVLINLVGNAIKFTDRgSVVLRVSLNDDSsLLFEVEDTGCGIAEE 626
|
170 180 190
....*....|....*....|....*....|....*.
gi 1915344185 395 DREQIFRPFYRTDEArdRESGGTGLGLAI----VEA 426
Cdd:TIGR02956 627 EQATLFDAFTQADGR--RRSGGTGLGLAIsqrlVEA 660
|
|
| marine_sort_HK |
TIGR03785 |
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is ... |
224-452 |
1.07e-15 |
|
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is paired with an adjacent response regulator (TIGR03787) gene. It co-occurs with a variant sortase enzyme (TIGR03784), usually in the same gene neighborhood, in proteobacterial species most of which are marine, and with an LPXTG motif-containing sortase target conserved protein (TIGR03788). Sortases and LPXTG proteins are far more common in Gram-positive bacteria, where sortase systems mediate attachment to the cell wall or cross-linking of pilin structures. We give this predicted sensor histidine kinase the gene symbol psdS, for Proteobacterial Dedicated Sortase system Sensor histidine kinase.
Pssm-ID: 163497 [Multi-domain] Cd Length: 703 Bit Score: 79.40 E-value: 1.07e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 224 SFNQMVTALE------RMMSSqhRLlsdiSHELRTP-------LTRLQLGTAllrrrSGESKE-LERIEMEAHRLDSMIN 289
Cdd:TIGR03785 470 SFAQMVARLRqythylENMSS--RL----SHELRTPvavvrssLENLELQAL-----EQEKQKyLERAREGTERLSMILN 538
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 290 DLLVMSR-NQAKTALVSETVKANQLWGEVLdnAAFEAEQMGKSFTVEYPPGPWPLYGNPNALESALENIVRNALRYSH-- 366
Cdd:TIGR03785 539 NMSEATRlEQAIQSAEVEDFDLSEVLSGCM--QGYQMTYPPQRFELNIPETPLVMRGSPELIAQMLDKLVDNAREFSPed 616
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 367 TKISVSFSVDKDGITVNVDDDGPGVSPEDREQIFRPFYRTDEARDRESGGTGLGLAIVEAAIQQHRGWVKADDSPLG-GL 445
Cdd:TIGR03785 617 GLIEVGLSQNKSHALLTVSNEGPPLPEDMGEQLFDSMVSVRDQGAQDQPHLGLGLYIVRLIADFHQGRIQAENRQQNdGV 696
|
....*..
gi 1915344185 446 RLTLWLP 452
Cdd:TIGR03785 697 VFRISLP 703
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
347-453 |
2.17e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 71.68 E-value: 2.17e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 347 PNALESALENIVRNALRY--SHTKISVSFSVDKDGITVNVDDDGPGVSPEDREQIFRPFYRTDEARDresgGTGLGLAIV 424
Cdd:cd16943 1 PSQLNQVLLNLLVNAAQAmeGRGRITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPFFTTKPVGE----GTGLGLSLS 76
|
90 100
....*....|....*....|....*....
gi 1915344185 425 EAAIQQHRGWVKADDSPLGGLRLTLWLPL 453
Cdd:cd16943 77 YRIIQKHGGTIRVASVPGGGTRFTIILPI 105
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
238-453 |
5.32e-15 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 77.76 E-value: 5.32e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 238 SQHrlLSDISHELRTPLTRLQLGTALLRRRSGESKELERIEMeAHR----LDSMINDLLVMSRNQA-KTALVSETVKANQ 312
Cdd:PRK15347 399 SEH--LTTISHEIRTPLNGVLGALELLQNTPLTAEQMDLADT-ARQctlsLLAIINNLLDFSRIESgQMTLSLEETALLP 475
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 313 LwgevLDNAAFEAEQMG--KSFTVEY---PPGPWPLYGNPNALESALENIVRNALRY-SHTKISVSFSVDKDGITVNVDD 386
Cdd:PRK15347 476 L----LDQAMLTIQGPAqsKSLTLRTfvgAHVPLYLHLDSLRLRQILVNLLGNAVKFtETGGIRLRVKRHEQQLCFTVED 551
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1915344185 387 DGPGVSPEDREQIFRPFYRTDEardrESGGTGLGLAIVEAAIQQHRGWVKADDSPLGGLRLTLWLPL 453
Cdd:PRK15347 552 TGCGIDIQQQQQIFTPFYQADT----HSQGTGLGLTIASSLAKMMGGELTLFSTPGVGSCFSLVLPL 614
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
350-452 |
5.46e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 70.43 E-value: 5.46e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 350 LESALENIVRNALRYSHTK----ISVSFSVDKDGITVNVDDDGPGVSPEDREQIFRPFYRTDEarDRESGGTGLGLAIVE 425
Cdd:cd16921 1 LGQVLTNLLGNAIKFRRPRrpprIEVGAEDVGEEWTFYVRDNGIGIDPEYAEKVFGIFQRLHS--REEYEGTGVGLAIVR 78
|
90 100
....*....|....*....|....*..
gi 1915344185 426 AAIQQHRGWVKADDSPLGGLRLTLWLP 452
Cdd:cd16921 79 KIIERHGGRIWLESEPGEGTTFYFTLP 105
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
246-453 |
5.70e-15 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 76.69 E-value: 5.70e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 246 ISHELRTPLTR----LQLgtaLLRRRSGESK-------ELERIEMeahrldsMINDLLVMSRNQAktaLVSETVKANQLW 314
Cdd:COG5805 294 IAHEIRNPLTSikgfLQL---LQPGIEDKEEyfdimlsELDRIES-------IISEFLALAKPQA---VNKEKENINELI 360
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 315 GEV---------LDNAAFEAEQMGKSFTVeyppgpwplYGNPNALESALENIVRNALRY--SHTKISVSFSVDKDGITVN 383
Cdd:COG5805 361 QDVvtlleteaiLHNIQIRLELLDEDPFI---------YCDENQIKQVFINLIKNAIEAmpNGGTITIHTEEEDNSVIIR 431
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 384 VDDDGPGVSPEDREQIFRPFYRTDEArdresgGTGLGLAIVEAAIQQHRGWVKADDSPLGGLRLTLWLPL 453
Cdd:COG5805 432 VIDEGIGIPEERLKKLGEPFFTTKEK------GTGLGLMVSYKIIENHNGTIDIDSKVGKGTTFTITLPL 495
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
354-453 |
1.48e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 69.44 E-value: 1.48e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 354 LENIVRNALRYShTKISVSFSVDKDG-------ITVNVDDDGPGVSPEDREQIFRPFYRTDEARDRESGGTGLGLAIVEA 426
Cdd:cd16922 5 LLNLLGNAIKFT-EEGEVTLRVSLEEeeedgvqLRFSVEDTGIGIPEEQQARLFEPFSQADSSTTRKYGGTGLGLAISKK 83
|
90 100 110
....*....|....*....|....*....|
gi 1915344185 427 AIQQHRG--WVKaddSPLG-GLRLTLWLPL 453
Cdd:cd16922 84 LVELMGGdiSVE---SEPGqGSTFTFTLPL 110
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
348-452 |
5.21e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 67.70 E-value: 5.21e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 348 NALESALenivrnALRYSHTKISVSFSVDKDGITVNVDDDGPGVSPEDREQIFRPFYRTDEARDResggtGLGLAIVEAA 427
Cdd:cd16915 11 NALDALA------ATGAPNKQVEVFLRDEGDDLVIEVRDTGPGIAPELRDKVFERGVSTKGQGER-----GIGLALVRQS 79
|
90 100
....*....|....*....|....*
gi 1915344185 428 IQQHRGWVKADDSPLGGLRLTLWLP 452
Cdd:cd16915 80 VERLGGSITVESEPGGGTTFSIRIP 104
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
242-453 |
7.09e-14 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 73.94 E-value: 7.09e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 242 LLSDISHE----LRTPLTRLQLGTALLRRRSGESKELERIEMEAHRLDSMINDLLVMSRnqaKTALVSETVKANQLWGEV 317
Cdd:PRK13837 453 LASGIAHNfnniLGAILGYAEMALNKLARHSRAARYIDEIISAGARARLIIDQILAFGR---KGERNTKPFDLSELVTEI 529
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 318 L--------DNAAFEAEQMGKSFTVEyppgpwplyGNPNALESALENIVRNALRYSHTKISVSFSVDK------------ 377
Cdd:PRK13837 530 ApllrvslpPGVELDFDQDQEPAVVE---------GNPAELQQVLMNLCSNAAQAMDGAGRVDISLSRaklrapkvlshg 600
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 378 -----DGITVNVDDDGPGVSPEDREQIFRPFYRTdeardrESGGTGLGLAIVEAAIQQHRGWVKADDSPLGGLRLTLWLP 452
Cdd:PRK13837 601 vlppgRYVLLRVSDTGAGIDEAVLPHIFEPFFTT------RAGGTGLGLATVHGIVSAHAGYIDVQSTVGRGTRFDVYLP 674
|
.
gi 1915344185 453 L 453
Cdd:PRK13837 675 P 675
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
350-441 |
8.34e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 67.43 E-value: 8.34e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 350 LESALENIVRNA---LRYSHTKISVSFSVD----------KDGITVNVDDDGPGVSPEDREQIFRPFYRTDEardresGG 416
Cdd:cd16918 1 LIQVFLNLVRNAaqaLAGSGGEIILRTRTQrqvtlghprhRLALRVSVIDNGPGIPPDLQDTIFYPMVSGRE------NG 74
|
90 100
....*....|....*....|....*
gi 1915344185 417 TGLGLAIVEAAIQQHRGWVKADDSP 441
Cdd:cd16918 75 TGLGLAIAQNIVSQHGGVIECDSQP 99
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
350-433 |
1.04e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 67.03 E-value: 1.04e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 350 LESALENIVRNALRYSHTKISVSFSVDKDGITVNVDDDGPGVSPEDR--EQIFRPFYRTDEARDreSGGTGLGLAIVEAA 427
Cdd:cd16923 1 LQRVFSNLLSNAIKYSPENTRIYITSFLTDDVVNIMFKNPSSHPLDFklEKLFERFYRGDNSRN--TEGAGLGLSIAKAI 78
|
....*.
gi 1915344185 428 IQQHRG 433
Cdd:cd16923 79 IELHGG 84
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
236-296 |
5.93e-13 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 63.39 E-value: 5.93e-13
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1915344185 236 MSSQHRLLSDISHELRTPLTRLQLGTALLRRRSGESKE----LERIEMEAHRLDSMINDLLVMSR 296
Cdd:cd00082 1 LQAKGEFLANVSHELRTPLTAIRGALELLEEELLDDEEqreyLERIREEAERLLRLINDLLDLSR 65
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
243-453 |
1.48e-12 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 69.93 E-value: 1.48e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 243 LSDISHELRTPLTRLqLGTALL---RRRSGESKE-LERIEMEAHRLDSMINDLLVMSRNQAKTALVS---ETVKANQLWG 315
Cdd:PRK11466 448 LAAMSHEIRTPLYGI-LGTAQLladNPALNAQRDdLRAITDSGESLLTILNDILDYSAIEAGGKNVSvsdEPFEPRPLLE 526
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 316 EVLDNAAFEAEQMGKSFTVEYPPG-PWPLYGNPNALESALENIVRNALRYSHT-KISVSFSVDKDGITVNVDDDGPGVSP 393
Cdd:PRK11466 527 STLQLMSGRVKGRPIRLATDIADDlPTALMGDPRRIRQVITNLLSNALRFTDEgSIVLRSRTDGEQWLVEVEDSGCGIDP 606
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 394 EDREQIFRPFYRTDEARdresGGTGLGLAIVEAAIQQHRGWVKADDSPLGGLRLTLWLPL 453
Cdd:PRK11466 607 AKLAEIFQPFVQVSGKR----GGTGLGLTISSRLAQAMGGELSATSTPEVGSCFCLRLPL 662
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
238-299 |
4.13e-12 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 61.07 E-value: 4.13e-12
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1915344185 238 SQHRLLSDISHELRTPLTRLQLGTALLRRR--SGESKE-LERIEMEAHRLDSMINDLLVMSRNQA 299
Cdd:pfam00512 1 AKSEFLANLSHELRTPLTAIRGYLELLRDEklDEEQREyLETILRSAERLLRLINDLLDLSRIEA 65
|
|
| nifL_nitrog |
TIGR02938 |
nitrogen fixation negative regulator NifL; NifL is a modulator of the nitrogen fixation ... |
227-453 |
5.12e-12 |
|
nitrogen fixation negative regulator NifL; NifL is a modulator of the nitrogen fixation positive regulator protein NifA, and is therefore a negative regulator. It binds NifA. NifA and NifL are encoded by adjacent genes. [Central intermediary metabolism, Nitrogen fixation, Regulatory functions, Protein interactions]
Pssm-ID: 131984 [Multi-domain] Cd Length: 494 Bit Score: 67.62 E-value: 5.12e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 227 QMVTALERMMSSQHRLLSDISHELRTPLTRLQLGTALLRRRSGE-----SKELERIEMEAHRlDSMIN--DLLVMSRNQA 299
Cdd:TIGR02938 264 QALMAEEERLEAIRETLSAAIHRLQGPMNLISAAISVLQRRGDDagnpaSAAMLQQALSAGR-EHMEAlrQVIPQSPQEI 342
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 300 KTalvseTVKANQLWGEVLDnaAFEAEQMGKSFTVEYPPG---PWpLYGNPNALESALENIVRNAL------RYSHTKIS 370
Cdd:TIGR02938 343 VV-----PVNLNQILRDVIT--LSTPRLLAAGIVVDWQPAatlPA-ILGRELQLRSLFKALVDNAIeamnikGWKRRELS 414
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 371 VSFSVDKDGITVNVDDDGPGVSPEDREQIFRPFYRTDEARDResgGTGLGLAIVEAAIQQHRGWVKADDSPLGGLRLTLW 450
Cdd:TIGR02938 415 ITTALNGDLIVVSILDSGPGIPQDLRYKVFEPFFTTKGGSRK---HIGMGLSVAQEIVADHGGIIDLDDDYSEGCRIIVE 491
|
...
gi 1915344185 451 LPL 453
Cdd:TIGR02938 492 FRV 494
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
224-455 |
5.88e-12 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 68.08 E-value: 5.88e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 224 SFNQMVTALERMMSSQHRLLSDISHELRTPLTRLQLGTALLRrrsgeSKELERiemEAHRLdsmindllVMSRNQAKTAL 303
Cdd:PRK10841 432 SLQEMAQAAEQASQSKSMFLATVSHELRTPLYGIIGNLDLLQ-----TKELPK---GVDRL--------VTAMNNSSSLL 495
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 304 VsetvkanQLWGEVLDNAAFEAEQMG---KSF---------TVEY----------------PPGPWPLYGNPNALESALE 355
Cdd:PRK10841 496 L-------KIISDILDFSKIESEQLKiepREFsprevinhiTANYlplvvkkrlglycfiePDVPVALNGDPMRLQQVIS 568
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 356 NIVRNALRYSHTK-ISVSFSVDKDGITVNVDDDGPGVSPEDREQIFRPFYRTDEARDRESGGTGLGLAIVEAAIQQHRGW 434
Cdd:PRK10841 569 NLLSNAIKFTDTGcIVLHVRVDGDYLSFRVRDTGVGIPAKEVVRLFDPFFQVGTGVQRNFQGTGLGLAICEKLINMMDGD 648
|
250 260
....*....|....*....|.
gi 1915344185 435 VKADDSPLGGLRLTLWLPLYK 455
Cdd:PRK10841 649 ISVDSEPGMGSQFTIRIPLYG 669
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
350-452 |
1.15e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 61.26 E-value: 1.15e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 350 LESALENIVRNALRY------SHTKISVSFSV-DKDGITVNVDDDGPGVSPEDREQIFRPFYRTdeardrESGGTGLGLA 422
Cdd:cd16920 1 IQQVLINLVRNGIEAmseggcERRELTIRTSPaDDRAVTISVKDTGPGIAEEVAGQLFDPFYTT------KSEGLGMGLS 74
|
90 100 110
....*....|....*....|....*....|
gi 1915344185 423 IVEAAIQQHRGWVKADDSPLGGLRLTLWLP 452
Cdd:cd16920 75 ICRSIIEAHGGRLSVESPAGGGATFQFTLP 104
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
238-299 |
1.20e-11 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 59.89 E-value: 1.20e-11
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1915344185 238 SQHRLLSDISHELRTPLTRLQLGTALLRRRSGESKE---LERIEMEAHRLDSMINDLLVMSRNQA 299
Cdd:smart00388 1 AKREFLANLSHELRTPLTAIRGYLELLLDTELSEEQreyLETILREAERLLRLINDLLDLSRIEA 65
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
342-441 |
2.95e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 60.60 E-value: 2.95e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 342 PLYGNPN--ALESALENIVRNALRYSHTK--ISVSFSVDKDGITVNVDDDGPGVSPEDREQIFRPFYRTDEARDRESGGT 417
Cdd:cd16947 11 PIYANANteALQRILKNLISNAIKYGSDGkfLGMTLREDEKHVYIDIWDKGKGISETEKDHVFERLYTLEDSRNSAKQGN 90
|
90 100
....*....|....*....|....
gi 1915344185 418 GLGLAIVEAAIQQHRGWVKADDSP 441
Cdd:cd16947 91 GLGLTITKRLAESMGGSIYVNSKP 114
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
238-454 |
3.07e-11 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 64.59 E-value: 3.07e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 238 SQHRLLSDISHELRTPLT-------RLQLGtalLRRRSGESKE--LERIEMEAHR----LDSMINDLLVMSRNQAkTALV 304
Cdd:PRK09303 150 FKDRVLAMLAHDLRTPLTaaslaleTLELG---QIDEDTELKPalIEQLQDQARRqleeIERLITDLLEVGRTRW-EALR 225
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 305 SETVKAN--QLWGEVLDNaaFEAEQMGKSFTVEYP-PGPWPL-YGNPNALESALENIVRNALRYS--HTKISVSF---SV 375
Cdd:PRK09303 226 FNPQKLDlgSLCQEVILE--LEKRWLAKSLEIQTDiPSDLPSvYADQERIRQVLLNLLDNAIKYTpeGGTITLSMlhrTT 303
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 376 DKdgITVNVDDDGPGVSPEDREQIFRPFYRTDeaRDRESGGTGLGLAIVEAAIQQHRG--WVkaDDSPLGGLRLTLWLPL 453
Cdd:PRK09303 304 QK--VQVSICDTGPGIPEEEQERIFEDRVRLP--RDEGTEGYGIGLSVCRRIVRVHYGqiWV--DSEPGQGSCFHFTLPV 377
|
.
gi 1915344185 454 Y 454
Cdd:PRK09303 378 Y 378
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
238-453 |
7.01e-11 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 64.76 E-value: 7.01e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 238 SQHRLLSDISHELRTPLTRLqLGTALLRRRSGESKElERIEMEAhrldsmindlLVMSRNQAKTALVSETVKANQL---- 313
Cdd:PRK09959 711 AKSQFLATMSHEIRTPISSI-MGFLELLSGSGLSKE-QRVEAIS----------LAYATGQSLLGLIGEILDVDKIesgn 778
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 314 ------WGEV---LDNA--AFEAEQMGKSFTVEYP---PGPWPLYGNPNALESALENIVRNALRYS---HTKISVSFSVD 376
Cdd:PRK09959 779 yqlqpqWVDIptlVQNTchSFGAIAASKSIALSCSstfPDHYLVKIDPQAFKQVLSNLLSNALKFTtegAVKITTSLGHI 858
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 377 KDG---ITVNVDDDGPGVSPEDREQIFRPFYRTDEArdRESGGTGLGLAIVEAAIQQHRGWVKADDSPLGGLRLTLWLPL 453
Cdd:PRK09959 859 DDNhavIKMTIMDSGSGLSQEEQQQLFKRYSQTSAG--RQQTGSGLGLMICKELIKNMQGDLSLESHPGIGTTFTITIPV 936
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
350-451 |
4.55e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 56.70 E-value: 4.55e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 350 LESALENIVRNALRYSHT----KISVSFSVDKDGITVNVDDDGPGVSPEDREQIFRPFYRTdeardRESG-GTGLGLAIV 424
Cdd:cd16976 1 IQQVLMNLLQNALDAMGKvenpRIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFFTT-----KPVGkGTGLGLSIS 75
|
90 100
....*....|....*....|....*..
gi 1915344185 425 EAAIQQHRGWVKADDSPLGGLRLTLWL 451
Cdd:cd16976 76 YGIVEEHGGRLSVANEEGAGARFTFDL 102
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
349-452 |
4.61e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 56.78 E-value: 4.61e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 349 ALESALENIVRNA--------LRYSHTKISVSFSVDKDgITVNVDDDGPGVSPEDREQIFRPFYRTDEArdresgGTGLG 420
Cdd:cd16944 4 QISQVLTNILKNAaeaiegrpSDVGEVRIRVEADQDGR-IVLIVCDNGKGFPREMRHRATEPYVTTRPK------GTGLG 76
|
90 100 110
....*....|....*....|....*....|..
gi 1915344185 421 LAIVEAAIQQHRGWVKADDSPLGGLRLTLWLP 452
Cdd:cd16944 77 LAIVKKIMEEHGGRISLSNREAGGACIRIILP 108
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
346-451 |
6.90e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 56.31 E-value: 6.90e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 346 NPNALESALENIVRNALRYS--HTKISVSFSVDKDGITVNVDDDGPGVSPEDREQIFRPFYRTDEARDRESGgTGLGLAI 423
Cdd:cd16945 1 DPFLLRQAINNLLDNAIDFSpeGGLIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFYSLPRPHSGQKS-TGLGLAF 79
|
90 100
....*....|....*....|....*...
gi 1915344185 424 VEAAIQQHRGWVKADDSPLGGLRlTLWL 451
Cdd:cd16945 80 VQEVAQLHGGRITLRNRPDGVLA-FLTL 106
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
243-430 |
7.71e-10 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 61.40 E-value: 7.71e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 243 LSDISHELRTPL------TRLQLGTALlrrRSGESKELERIEMEAHRLDSMINDLLVMSRNQA-KTALVS------ETVk 309
Cdd:PRK11107 297 LANMSHELRTPLngvigfTRQTLKTPL---TPTQRDYLQTIERSANNLLAIINDILDFSKLEAgKLVLENipfslrETL- 372
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 310 anqlwGEVLDNAAFEAEQMGKSFTVEYPPG-PWPLYGNPNALESALENIVRNALRYS---HTKISVSF-SVDKDGITVNV 384
Cdd:PRK11107 373 -----DEVVTLLAHSAHEKGLELTLNIDPDvPDNVIGDPLRLQQIITNLVGNAIKFTesgNIDILVELrALSNTKVQLEV 447
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 1915344185 385 D--DDGPGVSPEDREQIFRPFYRTDEARDRESGGTGLGLAIVEAAIQQ 430
Cdd:PRK11107 448 QirDTGIGISERQQSQLFQAFRQADASISRRHGGTGLGLVITQKLVNE 495
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
231-453 |
1.33e-09 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 60.34 E-value: 1.33e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 231 ALERMMSSQHRLLSDISHELRTP------LTRLQLGTALlrrRSGESKELERIEMEAHRLDSMINDLLVMSR-NQAKTAL 303
Cdd:PRK11091 275 ALEKASRDKTTFISTISHELRTPlngivgLSRILLDTEL---TAEQRKYLKTIHVSAITLGNIFNDIIDMDKmERRKLQL 351
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 304 VSETVKANQLWGEVLDNAAFEAEQMGKSFTVEyPPGPWPLY--GNPNALESALENIVRNALRYSHT-KISVSFSVD-KDG 379
Cdd:PRK11091 352 DNQPIDFTDFLADLENLSGLQAEQKGLRFDLE-PLLPLPHKviTDGTRLRQILWNLISNAVKFTQQgGVTVRVRYEeGDM 430
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1915344185 380 ITVNVDDDGPGVSPEDREQIFRPFYR-TDEARDRESGGTGLGLAIVEAAIQQHRGWVKADDSPLGGLRLTLWLPL 453
Cdd:PRK11091 431 LTFEVEDSGIGIPEDELDKIFAMYYQvKDSHGGKPATGTGIGLAVSKRLAQAMGGDITVTSEEGKGSCFTLTIHA 505
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
350-452 |
1.64e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 55.27 E-value: 1.64e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 350 LESALENIVRNALRYS---HTKISVSFSVDKDGITVNVDDDGPGVSPEDREQIFRPFYRTDEARDRESGGTGLGLAIVEA 426
Cdd:cd16953 1 LGQVLRNLIGNAISFSppdTGRITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFYTERPANEAFGQHSGLGLSISRQ 80
|
90 100 110
....*....|....*....|....*....|
gi 1915344185 427 AIQQHRGWVKA----DDSPLGGLRLTLWLP 452
Cdd:cd16953 81 IIEAHGGISVAenhnQPGQVIGARFTVQLP 110
|
|
| glnL |
PRK11073 |
nitrogen regulation protein NR(II); |
335-453 |
1.78e-09 |
|
nitrogen regulation protein NR(II);
Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 58.94 E-value: 1.78e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 335 EYPPGPWPLYGNPNALESALENIVRNALR---YSHTKISV----SFSVDKDGI------TVNVDDDGPGVSPEDREQIFR 401
Cdd:PRK11073 223 DYDPSLPELAHDPDQIEQVLLNIVRNALQalgPEGGTITLrtrtAFQLTLHGEryrlaaRIDIEDNGPGIPPHLQDTLFY 302
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 1915344185 402 PFYRTDEardresGGTGLGLAIVEAAIQQHRGWVKADDSPlGGLRLTLWLPL 453
Cdd:PRK11073 303 PMVSGRE------GGTGLGLSIARNLIDQHSGKIEFTSWP-GHTEFSVYLPI 347
|
|
| CpxA_peri |
pfam16527 |
Two-component sensor protein CpxA, periplasmic domain; CpxA_peri is the periplasmic ... |
81-144 |
3.21e-09 |
|
Two-component sensor protein CpxA, periplasmic domain; CpxA_peri is the periplasmic domain-family of the Gram-negative Gammaproteobacteria two-component signalling system, Cpx. It represents the recognition-site for sensing specific envelope stress signals. The fold that the domain-core of CpxA_peri conforms to is a PAS fold. The domain senses the environmental change and triggers a signal transduction to the cytoplasmic domain. As well as the PAS-core, there is a C-terminal tail that is necessary for ligand-sensing and binding to CpxP, a CpxA-associated and a regulatory protein. This domain recognizes KCl and RbCl (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 435400 [Multi-domain] Cd Length: 134 Bit Score: 55.12 E-value: 3.21e-09
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1915344185 81 PGQRLLLVTSEGRVIGAERN---EMQIIRNFIGQADNADHPQKKRYGRLEMVGPFSVRDGEDNYQLY 144
Cdd:pfam16527 51 GRPRFFFTDYEGEILTTKRRsdfRLKALRNFVTSIEDPQKPQQKLYGRYMMAGPVPITLADQTLLMY 117
|
|
| HATPase_CckA-like |
cd16919 |
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ... |
380-452 |
4.39e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).
Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 54.31 E-value: 4.39e-09
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1915344185 380 ITVNVDDDGPGVSPEDREQIFRPFYRTDEardrESGGTGLGLAIVEAAIQQHRGWVKADDSPLGGLRLTLWLP 452
Cdd:cd16919 48 VCLEVSDTGSGMPAEVLRRAFEPFFTTKE----VGKGTGLGLSMVYGFVKQSGGHLRIYSEPGVGTTVRIYLP 116
|
|
| ComP |
COG4585 |
Signal transduction histidine kinase ComP [Signal transduction mechanisms]; |
254-453 |
5.43e-09 |
|
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 56.55 E-value: 5.43e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 254 LTRLQLGTALLRRRSGESKELERIEMEAHRLDSMINDLLVMSRNqaktaLVSETVKANQLWGEVLDNAAFEAEQMGKSFT 333
Cdd:COG4585 71 AIKLQLEAARRLLDADPEAAREELEEIRELAREALAELRRLVRG-----LRPPALDDLGLAAALEELAERLLRAAGIRVE 145
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 334 VEYPPGPWPLygnPNALESALENIVR----NALRYSH-TKISVSFSVDKDGITVNVDDDGPGVSPEDReqifrpfyrtde 408
Cdd:COG4585 146 LDVDGDPDRL---PPEVELALYRIVQealtNALKHAGaTRVTVTLEVDDGELTLTVRDDGVGFDPEAA------------ 210
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 1915344185 409 ardresGGTGLGLAIVEAAIQQHRGWVKADDSPLGGLRLTLWLPL 453
Cdd:COG4585 211 ------PGGGLGLRGMRERAEALGGTLTIGSAPGGGTRVRATLPL 249
|
|
| PRK13557 |
PRK13557 |
histidine kinase; Provisional |
242-452 |
8.24e-08 |
|
histidine kinase; Provisional
Pssm-ID: 237425 [Multi-domain] Cd Length: 540 Bit Score: 54.29 E-value: 8.24e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 242 LLSDISHELRTPLTRLQLGTALLRR--RSGEskeleRIEMEAHRLDSMINDLLVMSRNQAktaLVSETVKANQLWGEVLD 319
Cdd:PRK13557 177 LLQVMSGYLDVIQAALSHPDADRGRmaRSVE-----NIRAAAERAATLTQQLLAFARKQR---LEGRVLNLNGLVSGMGE 248
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 320 NAAfeaEQMGKSFTVEY--PPGPWPLYGNPNALESALENIVRNA-----------LRYSHTKIS----VSFSVDKDG--I 380
Cdd:PRK13557 249 LAE---RTLGDAVTIETdlAPDLWNCRIDPTQAEVALLNVLINArdampeggrvtIRTRNVEIEdedlAMYHGLPPGryV 325
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1915344185 381 TVNVDDDGPGVSPEDREQIFRPFYRTDEardrESGGTGLGLAIVEAAIQQHRGWVKADDSPLGGLRLTLWLP 452
Cdd:PRK13557 326 SIAVTDTGSGMPPEILARVMDPFFTTKE----EGKGTGLGLSMVYGFAKQSGGAVRIYSEVGEGTTVRLYFP 393
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
190-433 |
3.29e-07 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 52.77 E-value: 3.29e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 190 ARKLKNAADEVAQGNLRQHPELEAGPQEFLAAGTSFNQMVTALERMMSSQHRLLSDISHElrtpltrlQLGTALlrrrsg 269
Cdd:COG4192 409 ERKRIEKNLRQTQDELIQAAKMAVVGQTMTSLAHELNQPLNAMSMYLFSAKKALEQENYA--------QLPTSL------ 474
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 270 eskelERIEMEAHRLDSMINDLLVMSRNQAKTA-LVSETVKANQLWGEVldnaAFEAEQMGKSFTVeypPGPWPLYGNPN 348
Cdd:COG4192 475 -----DKIEGLIERMDKIIKSLRQFSRKSDTPLqPVDLRQVIEQAWELV----ESRAKPQQITLHI---PDDLMVQGDQV 542
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 349 ALESALENIVRNALRYSHTK--ISVSFSVDKDGITVNVDDDGPGVspEDREQIFRPFYRTDEArdresgGTGLGLAIVEA 426
Cdd:COG4192 543 LLEQVLVNLLVNALDAVATQpqISVDLLSNAENLRVAISDNGNGW--PLVDKLFTPFTTTKEV------GLGLGLSICRS 614
|
....*..
gi 1915344185 427 AIQQHRG 433
Cdd:COG4192 615 IMQQFGG 621
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
353-424 |
6.10e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 47.67 E-value: 6.10e-07
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1915344185 353 ALENIVRNALRYSH--TKISVSFSVDKDGITVNVDDDGPGVSPEDREQIFRPFYrTDEARDRESGGTGLGLAIV 424
Cdd:cd16948 9 IIGQIVSNALKYSKqgGKIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKGF-TGENGRNFQESTGMGLYLV 81
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
169-453 |
1.30e-06 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 50.40 E-value: 1.30e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 169 IVTMLVSAPLLLWLAWSLAKPARKLKNAADEVAQGNLRQHPEleAGPQEFLAAGTSFNQMVTALERMMSSQHRLlsdish 248
Cdd:COG2972 164 LLLLLLALLLSYLLSRSITRPIKRLKKAMKKVEKGDLVRLEV--SGNDEIGILARSFNEMVERIKELIEEVYEL------ 235
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 249 ELRtpLTRLQLgtALLRRR--------SgeskeLERIEM-----EAHRLDSMINDLLVMSRNQAKTalVSETVkanqLWG 315
Cdd:COG2972 236 ELE--KKEAEL--KALQAQinphflfnT-----LNSIRWlaeleDPEEAEEMLEALSKLLRYSLSK--GDELV----TLE 300
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 316 EVLDNAA--FEAEQM--GKSFTVEY--PPGPW----------PLygnpnalesaLENIVRNALRYS--HTKISVSFSVDK 377
Cdd:COG2972 301 EELELIKsyLEIQKLrfGDRLEVEIeiDEELLdllipklilqPL----------VENAIEHGIEPKegGGTIRISIRKEG 370
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1915344185 378 DGITVNVDDDGPGVSPEDREQIFRPFyrtdearDRESGGTGLGLAIVEAAIQQHRG---WVKADDSPLGGLRLTLWLPL 453
Cdd:COG2972 371 DRLVITVEDNGVGMPEEKLEKLLEEL-------SSKGEGRGIGLRNVRERLKLYYGeeyGLEIESEPGEGTTVTIRIPL 442
|
|
| HATPase_UhpB-NarQ-NarX-like |
cd16917 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
357-452 |
7.17e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.
Pssm-ID: 340394 [Multi-domain] Cd Length: 87 Bit Score: 44.08 E-value: 7.17e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 357 IVR----NALRYSH-TKISVSFSVDKDGITVNVDDDGPGVSPEDREqifrpfyrtdeardresGGTGLGLAIVEAAIQQH 431
Cdd:cd16917 4 IVQealtNALKHAGaSRVRVTLSYTADELTLTVVDDGVGFDGPAPP-----------------GGGGFGLLGMRERAELL 66
|
90 100
....*....|....*....|.
gi 1915344185 432 RGWVKADDSPLGGLRLTLWLP 452
Cdd:cd16917 67 GGTLTIGSRPGGGTRVTARLP 87
|
|
| HAMP |
smart00304 |
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; |
188-237 |
1.30e-05 |
|
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;
Pssm-ID: 197640 [Multi-domain] Cd Length: 53 Bit Score: 42.24 E-value: 1.30e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 1915344185 188 KPARKLKNAADEVAQGNLRQHPELEaGPQEFLAAGTSFNQMVTALERMMS 237
Cdd:smart00304 5 RPLRRLAEAAQRIADGDLTVRLPVD-GRDEIGELARAFNEMADRLEETIA 53
|
|
| HATPase_RsbW-like |
cd16936 |
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase ... |
349-426 |
1.44e-05 |
|
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains; This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.
Pssm-ID: 340413 [Multi-domain] Cd Length: 91 Bit Score: 43.41 E-value: 1.44e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1915344185 349 ALESALENIVRNALRYSHTK-ISVSFSVDKDGITVNVDDDGPGVSPEDReqifrpfyRTDEARDRESggtGLGLAIVEA 426
Cdd:cd16936 4 AVSEAVTNAVRHAYRHDGPGpVRLELDLDPDRLRVEVTDSGPGFDPLRP--------ADPDAGLREG---GRGLALIRA 71
|
|
| HAMP |
cd06225 |
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; ... |
188-232 |
4.46e-05 |
|
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The structure of the Af1503 HAMP dimer from Archaeoglobus fulgidus has been solved using nuclear magnetic resonance, revealing a parallel four-helix bundle; this structure has been confirmed by cross-linking analysis of HAMP domains from the Escherichia coli aerotaxis receptor Aer. It has been suggested that the four-helix arrangement can rotate between the unusually packed conformation observed in the NMR structure and a canonical coiled-coil arrangement. Such rotation may coincide with signal transduction, but a common mechanism by which HAMP domains relay a variety of input signals has yet to be established.
Pssm-ID: 381743 [Multi-domain] Cd Length: 45 Bit Score: 40.51 E-value: 4.46e-05
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 1915344185 188 KPARKLKNAADEVAQGNLRQHPELEaGPQEFLAAGTSFNQMVTAL 232
Cdd:cd06225 2 RPLRRLTEAARRIAEGDLDVRVPVR-SKDEIGELARAFNQMAERL 45
|
|
| HAMP |
pfam00672 |
HAMP domain; |
188-234 |
4.66e-05 |
|
HAMP domain;
Pssm-ID: 459898 [Multi-domain] Cd Length: 53 Bit Score: 40.69 E-value: 4.66e-05
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 1915344185 188 KPARKLKNAADEVAQGNLRQHPElEAGPQEFLAAGTSFNQMVTALER 234
Cdd:pfam00672 8 RPLRRLAEAARRIASGDLDVRLP-VSGRDEIGELARAFNQMAERLRE 53
|
|
| PRK10618 |
PRK10618 |
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional |
232-419 |
8.88e-05 |
|
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional
Pssm-ID: 236726 [Multi-domain] Cd Length: 894 Bit Score: 44.92 E-value: 8.88e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 232 LERMMSSQHRLLSDISHELRTPLTRLQLGTALLRRRS---GESKELERIEMEAHRLDSMIND--LLVMSRNQAKTAlVSE 306
Cdd:PRK10618 443 YEKNQQARKAFLQNIGDELKQPLQSLAQLAAQLRQTSdeeQQQPELDQLAEQSDVLVRLVDNiqLLNMLETQDWKP-EQE 521
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 307 TVKANQLWGEVLDNAAFEAEQMGKSFTVEYPPGPWPLY-GNpnalESALENIVRNALRYSHT-----KISVSFSVDKDG- 379
Cdd:PRK10618 522 LFSLQDLIDEVLPEVLPAIKRKGLQLLIHNHLKAEQLRiGD----RDALRKILLLLLNYAITttaygKITLEVDQDESSp 597
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 1915344185 380 --ITVNVDDDGPGVSPEDREQIFRPFYrTDEARDRESGGTGL 419
Cdd:PRK10618 598 drLTIRILDTGAGVSIKELDNLHFPFL-NQTQGDRYGKASGL 638
|
|
| COG3920 |
COG3920 |
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ... |
33-453 |
3.08e-04 |
|
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];
Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 42.97 E-value: 3.08e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 33 RQMTELLESEQRQGIMIEQHVEAELANDPPNDLMWWRRLFRAIDKWAPPGQRLLLVTSEGRVIGAERNEMQIIRNFIGQA 112
Cdd:COG3920 89 LLLLLAAAALALALLLAALAGLLLLAALLLLRLVALLAALALLALLLLLLLLLAILALAELAVALAELAAALLLLAEELA 168
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 113 DNADHPQKKRYGRLEMVGPFSVRDGEDNYQLYLIRPANTSQSDFINLLFDRPLLLLIVTMLVSAPLLLWLAWSLAKPARK 192
Cdd:COG3920 169 ALRLAAAALLLLLAALLDLGLALAALAAAALLALLLALELLLALLLLLLLLLALLLVLLAALLRLRAAVLEELERRRRAR 248
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 193 LKNAADEVAQGNLRQHPELEAGPQEFLAAGTSFNQMVTALERMMSSQHRLLSDISHelrtpltR----LQLGTALLR--R 266
Cdd:COG3920 249 GLGRLLLLLLLLLLLLRALLLLAAGIRLVITERKRAEEELEASLEEKELLLRELHH-------RvknnLQVVSSLLRlqA 321
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 267 RSGESKELERIEMEA-HRLDSM--INDLLVMSRNqaktalvSETVKANQLWGEVLDNAAFEAEQMGKSFTVEYPPgpwpL 343
Cdd:COG3920 322 RRADDPEAREALEESqNRIQALalVHELLYQSED-------WEGVDLRDYLRELLEPLRDSYGGRGIRIELDGPD----V 390
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 344 YGNPNALES-AL---EnIVRNALRY-----SHTKISVSFSVDKDGITVNVDDDGPGVsPEDREqifrpfyrtdeardrES 414
Cdd:COG3920 391 ELPADAAVPlGLilnE-LVTNALKHaflsgEGGRIRVSWRREDGRLRLTVSDNGVGL-PEDVD---------------PP 453
|
410 420 430
....*....|....*....|....*....|....*....
gi 1915344185 415 GGTGLGLAIVEAAIQQHRGWVKADDSPlgGLRLTLWLPL 453
Cdd:COG3920 454 ARKGLGLRLIRALVRQLGGTLELDRPE--GTRVRITFPL 490
|
|
| Tar |
COG0840 |
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms]; |
74-331 |
7.16e-04 |
|
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
Pssm-ID: 440602 [Multi-domain] Cd Length: 533 Bit Score: 41.93 E-value: 7.16e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 74 AIDKWAPPGQRLLLVTSEGRVIGAERNEMQIIRNFIGQADNADHPQKKRYGRLEMVGPFSVRDGEDNYQLYLIRPANTSQ 153
Cdd:COG0840 94 ALLALALAALALLAALAALLALLELLLAALLAALAIALLALAALLALAALALALLALALLAAAAAAAAALAALLEAAALA 173
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 154 SDFINLLFDRPLLLLIVTMLVSAPLLLWLAWSLAKPARKLKNAADEVAQGNLRQHPELEaGPQEFLAAGTSFNQMVTALE 233
Cdd:COG0840 174 LAAAALALALLAAALLALVALAIILALLLSRSITRPLRELLEVLERIAEGDLTVRIDVD-SKDEIGQLADAFNRMIENLR 252
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 234 RMMSSqhrlLSDISHELRTPLTRLQLGTALLRRRSGE-SKELERIEMEAHRLDSMINDllvMSRNQAKTA-LVSETVKAN 311
Cdd:COG0840 253 ELVGQ----VRESAEQVASASEELAASAEELAAGAEEqAASLEETAAAMEELSATVQE---VAENAQQAAeLAEEASELA 325
|
250 260
....*....|....*....|
gi 1915344185 312 QLWGEVLDNAAFEAEQMGKS 331
Cdd:COG0840 326 EEGGEVVEEAVEGIEEIRES 345
|
|
| dpiB |
PRK15053 |
sensor histidine kinase DpiB; Provisional |
348-456 |
8.09e-04 |
|
sensor histidine kinase DpiB; Provisional
Pssm-ID: 185013 [Multi-domain] Cd Length: 545 Bit Score: 41.74 E-value: 8.09e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 348 NALESALENIVRNalRYSHTKISVSFSVDKDGITVNVDDDGPGVSPEDREQIFRPFYRTdeaRDRESGGTGLGLAIVEAA 427
Cdd:PRK15053 439 NLLDNAFEASLRS--DEGNKIVELFLSDEGDDVVIEVADQGCGVPESLRDKIFEQGVST---RADEPGEHGIGLYLIASY 513
|
90 100
....*....|....*....|....*....
gi 1915344185 428 IQQHRGWVKADDSPLGGLRLTLWLPLYKR 456
Cdd:PRK15053 514 VTRCGGVITLEDNDPCGTLFSIFIPKVKP 542
|
|
| PRK11086 |
PRK11086 |
sensory histidine kinase DcuS; Provisional |
348-430 |
6.54e-03 |
|
sensory histidine kinase DcuS; Provisional
Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 38.74 E-value: 6.54e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915344185 348 NALESALENIVRNALRyshtKISVSFSVDKDGITVNVDDDGPGVSPEDREQIFRPFYRTdeardrESGGTGLGLAIVEAA 427
Cdd:PRK11086 440 NLIENALEAVGGEEGG----EISVSLHYRNGWLHCEVSDDGPGIAPDEIDAIFDKGYST------KGSNRGVGLYLVKQS 509
|
...
gi 1915344185 428 IQQ 430
Cdd:PRK11086 510 VEN 512
|
|
| |
