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Conserved domains on  [gi|254806105|sp|C1ESX4|]
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RecName: Full=4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Short=CMK; AltName: Full=4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase

Protein Classification

4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase( domain architecture ID 11449259)

4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol in isoprenoid biosynthesis

CATH:  3.30.230.10
EC:  2.7.1.148
Gene Ontology:  GO:0050515|GO:0005524|GO:0016310|GO:0016114
PubMed:  12878729
SCOP:  4000959|4000643

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IspE COG1947
4-diphosphocytidyl-2C-methyl-D-erythritol kinase [Lipid transport and metabolism]; ...
 2-283 2.87e-147

4-diphosphocytidyl-2C-methyl-D-erythritol kinase [Lipid transport and metabolism]; 4-diphosphocytidyl-2C-methyl-D-erythritol kinase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


:

Pssm-ID: 441550 [Multi-domain]  Cd Length: 281  Bit Score: 414.13  E-value: 2.87e-147
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254806105   2 KLLVKAPAKINLSLDVLGKRQDGYHEVKMIMTTIDLADRLELMELAEDRIEILSHNRYVPDDQRNLAYQAAKLLKEKFNV 81
Cdd:COG1947    1 SLTVKAPAKINLFLHVTGRRPDGYHELETVFQFIDLGDTLTIEPADDGSISLTGPGAGVPTDEDNLVYRAARLLQEATGI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254806105  82 KKGVSITIEKTIPVAAGLAGGSSDAAATLRGLNKLWNLGLTIDQLAELGAEIGSDVSFCVYGGTAIATGRGEQIEHIKTP 161
Cdd:COG1947   81 PPGVDIHLEKRIPVGAGLGGGSSDAAATLRALNRLWGLGLSREELAELAAKLGADVPFFLYGGTALAEGRGEKLTPLPPL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254806105 162 PSCWVILAKPHIGVSTADVYGNLKLNRVT-HPNVDKMVDVINAGDyKGICDTVGNVLEDVTFAMHPEVARIKAQMKRFGA 240
Cdd:COG1947  161 PELWLVLVKPGVGVSTAEVYRALDLTRDTpPPDIDALLAALAAGD-AALAALLRNDLEPVAFKLYPEIAEVLEALLEAGA 239

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 254806105 241 DAVLMSGSGPTVFGLVHHDSRMHRIYNGLKGFCeQVYAVRLLG 283
Cdd:COG1947  240 LAARMSGSGSTVFGLFEDEEAAEAAAAALPARG-GVFVARTLN 281
 
Name Accession Description Interval E-value
IspE COG1947
4-diphosphocytidyl-2C-methyl-D-erythritol kinase [Lipid transport and metabolism]; ...
 2-283 2.87e-147

4-diphosphocytidyl-2C-methyl-D-erythritol kinase [Lipid transport and metabolism]; 4-diphosphocytidyl-2C-methyl-D-erythritol kinase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 441550 [Multi-domain]  Cd Length: 281  Bit Score: 414.13  E-value: 2.87e-147
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254806105   2 KLLVKAPAKINLSLDVLGKRQDGYHEVKMIMTTIDLADRLELMELAEDRIEILSHNRYVPDDQRNLAYQAAKLLKEKFNV 81
Cdd:COG1947    1 SLTVKAPAKINLFLHVTGRRPDGYHELETVFQFIDLGDTLTIEPADDGSISLTGPGAGVPTDEDNLVYRAARLLQEATGI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254806105  82 KKGVSITIEKTIPVAAGLAGGSSDAAATLRGLNKLWNLGLTIDQLAELGAEIGSDVSFCVYGGTAIATGRGEQIEHIKTP 161
Cdd:COG1947   81 PPGVDIHLEKRIPVGAGLGGGSSDAAATLRALNRLWGLGLSREELAELAAKLGADVPFFLYGGTALAEGRGEKLTPLPPL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254806105 162 PSCWVILAKPHIGVSTADVYGNLKLNRVT-HPNVDKMVDVINAGDyKGICDTVGNVLEDVTFAMHPEVARIKAQMKRFGA 240
Cdd:COG1947  161 PELWLVLVKPGVGVSTAEVYRALDLTRDTpPPDIDALLAALAAGD-AALAALLRNDLEPVAFKLYPEIAEVLEALLEAGA 239

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 254806105 241 DAVLMSGSGPTVFGLVHHDSRMHRIYNGLKGFCeQVYAVRLLG 283
Cdd:COG1947  240 LAARMSGSGSTVFGLFEDEEAAEAAAAALPARG-GVFVARTLN 281
ispE TIGR00154
4-diphosphocytidyl-2C-methyl-D-erythritol kinase; Members of this family of GHMP kinases were ...
 1-284 4.19e-129

4-diphosphocytidyl-2C-methyl-D-erythritol kinase; Members of this family of GHMP kinases were previously designated as conserved hypothetical protein YchB or as isopentenyl monophosphate kinase. It is now known, in tomato and E. coli, to encode 4-diphosphocytidyl-2C-methyl-D-erythritol kinase, an enzyme of the deoxyxylulose phosphate pathway of terpenoid biosynthesis. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]


Pssm-ID: 188029 [Multi-domain]  Cd Length: 294  Bit Score: 368.76  E-value: 4.19e-129
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254806105    1 MKLLVKAPAKINLSLDVLGKRQDGYHEVKMIMTTIDLADRLELMELAEDRIEILSHNRYVPDDQrNLAYQAAKLLKEKFN 80
Cdd:TIGR00154   1 MRHVFPAPAKINLFLYILGKRPDGYHELQMLMQFIDLGDKIIISVRSDDDIRLLKGDFDVPLEE-NLAYRAAQLLKNFAN 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254806105   81 ----VKKGVSITIEKTIPVAAGLAGGSSDAAATLRGLNKLWNLGLTIDQLAELGAEIGSDVSFCVYGGTAIATGRGEQIE 156
Cdd:TIGR00154  80 skikSLDGVNIEITKNIPMAAGLGGGSSDAAAVLVGLNQLWNLGLSLEELAELGATLGADVPFFVSGGTAFATGRGEIIT 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254806105  157 HIKTPPSCWVILAKPHIGVSTADVYGNLKLNRVTHPNVDKMVDVINAGDYKGICDTVGNVLEDVTFAMHPEVARIKAQMK 236
Cdd:TIGR00154 160 PFEDPPEKWVVIAKPHVSVSTPVVYQAYKLPRNTPKRAKEWLKKISLECLQLLDSNGLNDLEKVALKRHTEVAQALNWLL 239

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 254806105  237 RFGADAVLMSGSGPTVFGLVHHDSRMHRIYN----GLKGFCEQVYAVRLLGE 284
Cdd:TIGR00154 240 EYGLAPERMSGSGPCVFALFDMESEAEQVLEqapeWLNGFVAKGYNVSPIGR 291
PRK03188 PRK03188
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional
 5-252 4.58e-66

4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional


Pssm-ID: 235110 [Multi-domain]  Cd Length: 300  Bit Score: 208.21  E-value: 4.58e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254806105   5 VKAPAKINLSLDVLGKRQDGYHEVKMIMTTIDLADRLELMELAEDRIEILSHN-RYVPDDQRNLAYQAAKLLKEKFNVKK 83
Cdd:PRK03188   3 VRAPAKVNLHLGVGPLRDDGYHELATVFQAVSLYDEVTVTAADVLSVEVSGEGaDQVPTDESNLAWRAAELLAEHVGRAP 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254806105  84 GVSITIEKTIPVAAGLAGGSSDAAATLRGLNKLWNLGLTIDQLAELGAEIGSDVSFCVYGGTAIATGRGEQIEHIKTPPS 163
Cdd:PRK03188  83 DVHLHIDKGIPVAGGMAGGSADAAAALVACDALWGLGLSRDELLELAAELGSDVPFALLGGTALGTGRGEQLAPVLARGT 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254806105 164 CWVILAKPHIGVSTADVYGNL-KLNRVTHPN----VDKMVDVINAGDYKGICDTVGNVLEDVTFAMHPEVARIKAQMKRF 238
Cdd:PRK03188 163 FHWVLAFADGGLSTPAVFRELdRLREAGDPPrlgePDPLLAALRAGDPAQLAPLLGNDLQAAALSLRPSLRRTLRAGEEA 242

                        250
                 ....*....|....
gi 254806105 239 GADAVLMSGSGPTV 252
Cdd:PRK03188 243 GALAGIVSGSGPTC 256
GHMP_kinases_N pfam00288
GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and ...
 86-144 9.82e-17

GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and mevalonate kinases.


Pssm-ID: 395225 [Multi-domain]  Cd Length: 64  Bit Score: 72.58  E-value: 9.82e-17
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 254806105   86 SITIEKTIPVAAGLAGGSSDAAATLRGLNKLWN-----LGLTIDQLAELGAEIGSDVSFCVYGG 144
Cdd:pfam00288   1 DIEIESNIPLGAGLGSSAALAVALLLALNELFGlplakLALEAEELAGGGRGGGMDVAASLYGG 64
 
Name Accession Description Interval E-value
IspE COG1947
4-diphosphocytidyl-2C-methyl-D-erythritol kinase [Lipid transport and metabolism]; ...
 2-283 2.87e-147

4-diphosphocytidyl-2C-methyl-D-erythritol kinase [Lipid transport and metabolism]; 4-diphosphocytidyl-2C-methyl-D-erythritol kinase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 441550 [Multi-domain]  Cd Length: 281  Bit Score: 414.13  E-value: 2.87e-147
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254806105   2 KLLVKAPAKINLSLDVLGKRQDGYHEVKMIMTTIDLADRLELMELAEDRIEILSHNRYVPDDQRNLAYQAAKLLKEKFNV 81
Cdd:COG1947    1 SLTVKAPAKINLFLHVTGRRPDGYHELETVFQFIDLGDTLTIEPADDGSISLTGPGAGVPTDEDNLVYRAARLLQEATGI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254806105  82 KKGVSITIEKTIPVAAGLAGGSSDAAATLRGLNKLWNLGLTIDQLAELGAEIGSDVSFCVYGGTAIATGRGEQIEHIKTP 161
Cdd:COG1947   81 PPGVDIHLEKRIPVGAGLGGGSSDAAATLRALNRLWGLGLSREELAELAAKLGADVPFFLYGGTALAEGRGEKLTPLPPL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254806105 162 PSCWVILAKPHIGVSTADVYGNLKLNRVT-HPNVDKMVDVINAGDyKGICDTVGNVLEDVTFAMHPEVARIKAQMKRFGA 240
Cdd:COG1947  161 PELWLVLVKPGVGVSTAEVYRALDLTRDTpPPDIDALLAALAAGD-AALAALLRNDLEPVAFKLYPEIAEVLEALLEAGA 239

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 254806105 241 DAVLMSGSGPTVFGLVHHDSRMHRIYNGLKGFCeQVYAVRLLG 283
Cdd:COG1947  240 LAARMSGSGSTVFGLFEDEEAAEAAAAALPARG-GVFVARTLN 281
ispE TIGR00154
4-diphosphocytidyl-2C-methyl-D-erythritol kinase; Members of this family of GHMP kinases were ...
 1-284 4.19e-129

4-diphosphocytidyl-2C-methyl-D-erythritol kinase; Members of this family of GHMP kinases were previously designated as conserved hypothetical protein YchB or as isopentenyl monophosphate kinase. It is now known, in tomato and E. coli, to encode 4-diphosphocytidyl-2C-methyl-D-erythritol kinase, an enzyme of the deoxyxylulose phosphate pathway of terpenoid biosynthesis. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]


Pssm-ID: 188029 [Multi-domain]  Cd Length: 294  Bit Score: 368.76  E-value: 4.19e-129
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254806105    1 MKLLVKAPAKINLSLDVLGKRQDGYHEVKMIMTTIDLADRLELMELAEDRIEILSHNRYVPDDQrNLAYQAAKLLKEKFN 80
Cdd:TIGR00154   1 MRHVFPAPAKINLFLYILGKRPDGYHELQMLMQFIDLGDKIIISVRSDDDIRLLKGDFDVPLEE-NLAYRAAQLLKNFAN 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254806105   81 ----VKKGVSITIEKTIPVAAGLAGGSSDAAATLRGLNKLWNLGLTIDQLAELGAEIGSDVSFCVYGGTAIATGRGEQIE 156
Cdd:TIGR00154  80 skikSLDGVNIEITKNIPMAAGLGGGSSDAAAVLVGLNQLWNLGLSLEELAELGATLGADVPFFVSGGTAFATGRGEIIT 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254806105  157 HIKTPPSCWVILAKPHIGVSTADVYGNLKLNRVTHPNVDKMVDVINAGDYKGICDTVGNVLEDVTFAMHPEVARIKAQMK 236
Cdd:TIGR00154 160 PFEDPPEKWVVIAKPHVSVSTPVVYQAYKLPRNTPKRAKEWLKKISLECLQLLDSNGLNDLEKVALKRHTEVAQALNWLL 239

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 254806105  237 RFGADAVLMSGSGPTVFGLVHHDSRMHRIYN----GLKGFCEQVYAVRLLGE 284
Cdd:TIGR00154 240 EYGLAPERMSGSGPCVFALFDMESEAEQVLEqapeWLNGFVAKGYNVSPIGR 291
PRK03188 PRK03188
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional
 5-252 4.58e-66

4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional


Pssm-ID: 235110 [Multi-domain]  Cd Length: 300  Bit Score: 208.21  E-value: 4.58e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254806105   5 VKAPAKINLSLDVLGKRQDGYHEVKMIMTTIDLADRLELMELAEDRIEILSHN-RYVPDDQRNLAYQAAKLLKEKFNVKK 83
Cdd:PRK03188   3 VRAPAKVNLHLGVGPLRDDGYHELATVFQAVSLYDEVTVTAADVLSVEVSGEGaDQVPTDESNLAWRAAELLAEHVGRAP 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254806105  84 GVSITIEKTIPVAAGLAGGSSDAAATLRGLNKLWNLGLTIDQLAELGAEIGSDVSFCVYGGTAIATGRGEQIEHIKTPPS 163
Cdd:PRK03188  83 DVHLHIDKGIPVAGGMAGGSADAAAALVACDALWGLGLSRDELLELAAELGSDVPFALLGGTALGTGRGEQLAPVLARGT 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254806105 164 CWVILAKPHIGVSTADVYGNL-KLNRVTHPN----VDKMVDVINAGDYKGICDTVGNVLEDVTFAMHPEVARIKAQMKRF 238
Cdd:PRK03188 163 FHWVLAFADGGLSTPAVFRELdRLREAGDPPrlgePDPLLAALRAGDPAQLAPLLGNDLQAAALSLRPSLRRTLRAGEEA 242

                        250
                 ....*....|....
gi 254806105 239 GADAVLMSGSGPTV 252
Cdd:PRK03188 243 GALAGIVSGSGPTC 256
PRK14608 PRK14608
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional
 1-259 7.82e-60

4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional


Pssm-ID: 237765 [Multi-domain]  Cd Length: 290  Bit Score: 191.99  E-value: 7.82e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254806105   1 MKLLVKAPAKINLSLDVLGKRQDGYHEVKMIMTTIDLADRLELMELAEDRIEI-------LshnryvPDDQRNLAYQAAK 73
Cdd:PRK14608   5 PSLTEFAPAKINLALHVTGRRADGYHLLESLVAFADVGDRLTLEPAEALSLTVsgpfaagL------GDGDDNLVLRAAR 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254806105  74 LLKEKFN-VKKGVSITIEKTIPVAAGLAGGSSDAAATLRGLNKLWNLGLTIDQLAELGAEIGSDVSFCVYGGTAIATGRG 152
Cdd:PRK14608  79 ALRARVGpGLPPGAFHLEKNLPVAAGIGGGSADAAAALRLLARLWGLALDDERLAALALSLGADVPVCLDSRPLIMRGIG 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254806105 153 EQIEHIKTPPSCWVILAKPHIGVSTADVYGNLKLnRVTHPNVDKMVDVINAGDYKGICDTVGNVLEDVTFAMHPEVARIK 232
Cdd:PRK14608 159 EELTPLPGLPSLPAVLVNPGVPVATPDVFRALGL-RDGPPLPGAPDPLASADALLAALAATRNDLEPPALALAPVIGEVL 237

                        250       260
                 ....*....|....*....|....*...
gi 254806105 233 AQM-KRFGADAVLMSGSGPTVFGLVHHD 259
Cdd:PRK14608 238 AALrAQPGALLARMSGSGATCFALFADE 265
PRK14611 PRK14611
4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase;
5-253 1.59e-51

4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase;


Pssm-ID: 184767 [Multi-domain]  Cd Length: 275  Bit Score: 170.32  E-value: 1.59e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254806105   5 VKAPAKINLSLDVLGKRQDGYHEVKMIMTTIDLADRLELMElaEDRIEILSHNRYVPDDQrNLAYQAAKLLKEKFNVKKG 84
Cdd:PRK14611   4 LLSPAKVNLGLWILGKRPDGYHEIFTIYHTIDLYDRIYIKE--HHTLEVKTSSPQIKEEE-NIVYKALRLFERYTGIDIN 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254806105  85 VSITIEKTIPVAAGLAGGSSDAAATLRGLNKLWNLGLTIDQLAELGAEIGSDVSFCVYGGTAIATGRGEQIEHIKTPPSC 164
Cdd:PRK14611  81 YSIFIEKNIPVGAGLGGGSSNAAVVLKYLNELLGNPLSEEELFELASSISADAPFFLKGGFALGRGIGDKLEFLEKPISR 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254806105 165 WVILAKPHIGVSTADVYGNLKLNRVTHP-NVDKMVDVINAGDYKGICDTVGNVLEDVTFAMHPEVARIKAQMKRFGADAV 243
Cdd:PRK14611 161 EITLVYPNIKSSTGRVYSKVTKQILTNKeDLNIIISLLREGEEKKIEEVIENTLGEIALELYPEIKEVYRFLEYLGYKPF 240

                        250
                 ....*....|
gi 254806105 244 lMSGSGPTVF 253
Cdd:PRK14611 241 -VSGSGSSVY 249
PRK14613 PRK14613
4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase;
7-256 1.08e-37

4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase;


Pssm-ID: 173077 [Multi-domain]  Cd Length: 297  Bit Score: 135.03  E-value: 1.08e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254806105   7 APAKINLSLDVLGKRQDGYHEVKMIMTTIDLADRLELMELAEDRIEILSHNRYV-------------PDDQRNLAYQAAK 73
Cdd:PRK14613   3 SPAKINLGLEIPFKREDGFHEIRSVFLKISWGDDIEIEPAPNGVFELFSTNEIIlekrklydqvserGDIKQNILYKTFI 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254806105  74 LLKEKFNVKKGVSITIEKTIPVAAGLAGGSSDAAATLRGLNKLWNLgLTIDQLAELGAEIGSDVSFCVYGGTAIATGRGE 153
Cdd:PRK14613  83 KARSLFPELPGVKIHLTKRISPAGGLGGGSTNAASLLNFLFSWRNF-FTSDEMQVFAKEIGSDVPFFLGEGHAFVTGKGE 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254806105 154 QIEHIKTPPScWVILAKPHIGVSTADVYGNLKL-------NRVTHPNVDKMVDVINAGDYKGICDTVGNVLEDVTFAMHP 226
Cdd:PRK14613 162 IMEEIEVHKG-QGILALTPQVMNTGEMYALLKKplqesasQKNGNTLSEDLISSLKVGDWVSLQGRLENDFEPVAFQLHP 240

                        250       260       270
                 ....*....|....*....|....*....|
gi 254806105 227 EVARIKAQMKRFGADAVLMSGSGPTVFGLV 256
Cdd:PRK14613 241 ELGVLKDKFLEFGSSYCSLTGSGSSMYGLV 270
PRK04181 PRK04181
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional
 6-181 2.24e-28

4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional


Pssm-ID: 235243  Cd Length: 257  Bit Score: 109.28  E-value: 2.24e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254806105   6 KAPAKINLSLDVLGKRqDGYHEVKMIMTTI-DLADRLELMELAEDRIEILSHnrYVPDDQRNLAYQAAKLLKEKFNVK-- 82
Cdd:PRK04181   4 KAYAKVNIFLKILGKR-GNYHELISRFVLVkDLFDEIEFVPKSAESFELIGN--FDCPLEENIIYKAYQELKNKGFSNel 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254806105  83 ----KGVSITIEKTIPVAAGLAGGSSDAAATLRGLNKLWNLGLTIDQLAELGAEIGSDVSFCVYG-GTAIATGRGEQIEH 157
Cdd:PRK04181  81 ieffKKKAIEVEKNIPTGAGLGGGSSDAATFLLMLNEILNLKLSLEELAEIGSKVGADVAFFISGyKSANVSGIGEIVEE 160

                        170       180
                 ....*....|....*....|....*
gi 254806105 158 IK-TPPSCWVIlaKPHIGVSTADVY 181
Cdd:PRK04181 161 FEeEILNLEIF--TPNIFCSTKAVY 183
PRK01212 PRK01212
homoserine kinase; Provisional
 1-259 1.32e-27

homoserine kinase; Provisional


Pssm-ID: 234920 [Multi-domain]  Cd Length: 301  Bit Score: 108.31  E-value: 1.32e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254806105   1 MKLLVKAPAKI-NLS--LDVLGkrqdgyhevkmimTTIDLADRLELME----LAEDRIEILSH-NRYVP-DDQRNLAYQA 71
Cdd:PRK01212   2 MMVKVRVPATSaNLGpgFDSLG-------------LALSLYDEVLVGDvvsvEAEFSIEVIGEgADKLPlDPEKNLVYQA 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254806105  72 AKLLKEKFNVKKGVSITIEKTIPVAAGLagGSSDAA--ATLRGLNKLWNLGLTIDQLAELGAEIGS--D-VSFCVYGG-T 145
Cdd:PRK01212  69 ALKFLEKLGKPPGLRIELEKNIPLGRGL--GSSAASivAGLVAANELAGLPLSKEELLQLATEGEGhpDnVAPALLGGlV 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254806105 146 AIATGRGEQIEHIKTPPSCWVILAKPHIGVSTADVygnlklnRVTHPNVDKMVDVINA-------------GDYkgicDT 212
Cdd:PRK01212 147 LALEENGVISVKIPVFDDLKWVVAIPNIELSTAEA-------RAVLPKQYSLKDAVFNssraallvaalytGDY----EL 215

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 254806105 213 VGNVLEDVtfaMH--------PEVARIKAQMKRFGADAVLMSGSGPTVFGLVHHD 259
Cdd:PRK01212 216 AGRAMKDV---LHepyrakliPGFAEVRQAALEAGALGAGISGAGPTVFALCDKE 267
GHMP_kinases_N pfam00288
GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and ...
 86-144 9.82e-17

GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and mevalonate kinases.


Pssm-ID: 395225 [Multi-domain]  Cd Length: 64  Bit Score: 72.58  E-value: 9.82e-17
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 254806105   86 SITIEKTIPVAAGLAGGSSDAAATLRGLNKLWN-----LGLTIDQLAELGAEIGSDVSFCVYGG 144
Cdd:pfam00288   1 DIEIESNIPLGAGLGSSAALAVALLLALNELFGlplakLALEAEELAGGGRGGGMDVAASLYGG 64
ERG12 COG1577
Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway ...
 31-249 2.23e-14

Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 441185 [Multi-domain]  Cd Length: 277  Bit Score: 71.41  E-value: 2.23e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254806105  31 IMTTIDLADRLELMELAEDRIEILSHN-----RYVPDDQRNLAY--QAAKLLKEKFNVK-KGVSITIEKTIPVAAGLagG 102
Cdd:COG1577   20 IAVAVDRRATVTVEPSDDDKLRIESPDlggtlDLDPLADAALRYikAAIEAALEYLGLPlKGFDIEIDSEIPRKRGL--G 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254806105 103 SSDA--AATLRGLNKLWNLGLTIDQLAELGAEI-------GS--DVSFCVYGGtAIATGRGEQIEHIKTPPSCWVILAkp 171
Cdd:COG1577   98 SSAAvaVAVIRALAAFYGVELSKEELFKLALEAekivhgnPSglDTAASTYGG-PIYYQRGDRAEPLELPKNLPLVVG-- 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254806105 172 HIGV--STADVYGNLKLNRVTHPN------------VDKMVDVINAGDYKGICDTVgNVLEDVTFAM---HPEVARIKAQ 234
Cdd:COG1577  175 DTGVpaSTKELVAKVRKLKERNPElyeafleeigdlVEEAIEALEEGDLEALGELM-NENHGLLRALgvsTPELDRLVEA 253

                        250
                 ....*....|....*
gi 254806105 235 MKRFGADAVLMSGSG 249
Cdd:COG1577  254 ARKAGALGAKLTGAG 268
PRK05905 PRK05905
4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase;
5-253 5.56e-14

4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase;


Pssm-ID: 235642  Cd Length: 258  Bit Score: 70.26  E-value: 5.56e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254806105   5 VKAPAKINLSLDVLGKRQDgyhevkmiMTTIDLADRLELMELAEDRIEILSHNRYVPD----DQRNLAY--------QAA 72
Cdd:PRK05905   3 YKSYAKINLGLSIYKKCKK--------VTKHKLESIFILVENVYDDIEIEKIEKNIDDihyfDETNEILvysrlilvKTL 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254806105  73 KLLKEKFNVKKGVSITIEKTIPVAAGLAGGSSDAAATLRGLNKLWnlGLTIDQLAELGAEIGSDVSFCVYG-GTAIATGR 151
Cdd:PRK05905  75 EWLRDKYNIKNHFKIKIKKRIPIGSGLGSGSSNAAVLMKWILEFE--GINEINYKDVVNKLGSDIPFFLSGyKTAYISDY 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254806105 152 GEQIEHIKTPPSCWVILAKPHIGVSTADVYGNLKLNR-VTHPNVDKMVDVINAGDYKGIcdtvGNVLEDVTFAMHPEVAR 230
Cdd:PRK05905 153 GSQVEDLIGQFKLTYKVIFMNVNVSTKKVFEKFDDNQhVIKNNFKTIIKNLKENIVVNI----HNDLQEPCFELYPNLLY 228

                        250       260
                 ....*....|....*....|...
gi 254806105 231 IKAQMKRFGADAVLmSGSGPTVF 253
Cdd:PRK05905 229 KYNELLNDGFYTIL-SGAGSSFI 250
PRK03926 PRK03926
mevalonate kinase; Provisional
 7-209 5.25e-13

mevalonate kinase; Provisional


Pssm-ID: 179677 [Multi-domain]  Cd Length: 302  Bit Score: 67.77  E-value: 5.25e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254806105   7 APAKINLSldvlgkrqdGYHEV----KMIMTTIDLADRLElMELAEDRIEILSHNRYVPDdqrNLAY--QAAKLLKEKFN 80
Cdd:PRK03926   6 APGKIYLF---------GEHAVvygkPAIACAIDLRTYVR-AEFNDDSIYIESDYGKTGE---KHPYvsAAIEKMREEAD 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254806105  81 vKKGVSITIEKTIPVAAGLagGSSDAA--ATLRGLNKLWNLGLTIDQLAELGAEI---------GSDVSFCVYGGTAIAt 149
Cdd:PRK03926  73 -KDGVTVSITSQIPVGSGL--GSSAAVtvATIGALNRLLGLGLSLEEIAKLGHKVellvqgaasPTDTYVSTMGGFVTI- 148

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 254806105 150 grgEQIEHIKtPPSCWVILAKPHIGVSTADVYGNLKLNRVTHPNV------------DKMVDVINAGDYKGI 209
Cdd:PRK03926 149 ---PDRKKLP-FPECGIVVGYTGSSGSTKELVANVRKLKEEYPELiepilssigkisEKGEELILSGDYVSL 216
GHMP_kinases_C pfam08544
GHMP kinases C terminal; This family includes homoserine kinases, galactokinases and ...
 217-275 4.30e-06

GHMP kinases C terminal; This family includes homoserine kinases, galactokinases and mevalonate kinases.


Pssm-ID: 430063 [Multi-domain]  Cd Length: 85  Bit Score: 44.00  E-value: 4.30e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 254806105  217 LEDVTFAMHPEVARIKAQMKRFGADAVL-MSGSGPTVFGLVHHDSRMHRIYNGLKGFCEQ 275
Cdd:pfam08544  26 PLLVVGILPPELDELLEALLELGLGAKLsGSGGGPTVFALFKDEDDAEEVARALREAGKK 85
PLN02451 PLN02451
homoserine kinase
 62-138 2.55e-03

homoserine kinase


Pssm-ID: 215248  Cd Length: 370  Bit Score: 39.00  E-value: 2.55e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 254806105  62 DDQRNLAYQAAKLLKEKFNVKK-GVSITIEKTIPVAAGLAGGSSDAAATLRGLNKLWNLGLTIDQLAELGAEIGSDVS 138
Cdd:PLN02451 111 DPLRNCAGIAAIATMKLLGIRSvGLSLSLHKGLPLGSGLGSSAASAAAAAVAVNELFGSPLGKDDLVLAGLESEAKVS 188
PRK03817 PRK03817
galactokinase; Provisional
 72-132 4.51e-03

galactokinase; Provisional


Pssm-ID: 235163 [Multi-domain]  Cd Length: 351  Bit Score: 38.05  E-value: 4.51e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 254806105  72 AKLLKEKFNVKkGVSITIEKTIPVAAGLaggSSDAA---ATLRGLNKLWNLGLTIDQLAELGAE 132
Cdd:PRK03817  75 WVLEKRGYEVG-GVKGKVSSNLPIGAGL---SSSASlevAVAYALNEAYNLNLSKLELALLARE 134
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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