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Conserved domains on  [gi|3413295|emb|CAA11832|]
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gamma-adaptin protein, partial [Homo sapiens]

Protein Classification

HEAT repeat domain-containing protein( domain architecture ID 1001770)

HEAT repeat domain-containing protein similar to the N-terminal region of various adaptins

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Adaptin_N super family cl37648
Adaptin N terminal region; This family consists of the N terminal region of various alpha, ...
 23-180 5.37e-63

Adaptin N terminal region; This family consists of the N terminal region of various alpha, beta and gamma subunits of the AP-1, AP-2 and AP-3 adaptor protein complexes. The adaptor protein (AP) complexes are involved in the formation of clathrin-coated pits and vesicles. The N-terminal region of the various adaptor proteins (APs) is constant by comparison to the C-terminal which is variable within members of the AP-2 family; and it has been proposed that this constant region interacts with another uniform component of the coated vesicles.


The actual alignment was detected with superfamily member pfam01602:

Pssm-ID: 396262 [Multi-domain]  Cd Length: 523  Bit Score: 202.47  E-value: 5.37e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3413295     23 EREMIQKECAAIRSSFREEDNtYRCRNVAKLLYMHMLGNPAHFGQLECLKLIASQKFTDKRIGYLGAMLLLDERQDVHLL 102
Cdd:pfam01602   1 EEKRIQQELARILNSFRDDPR-KKKNAVKKLLYLIMLGEDISFLFFEVVKLVASKDFTLKRLGYLYLMLLAEESPDLAIL 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 3413295    103 MTNCIKNDLNHSTQFVQGLALCTLGCMGSSEMCRDLAGKVEKLLKTSNSYLKKKAALCAVHVIRKVPELMENVLPATK 180
Cdd:pfam01602  80 VTNSIQKDLQSPNQLIRGLALRTLSCIRVPELARDLAPDIKKLLVDRSPYVRKKAALAILKLYRKSPDLVRDFVPELK 157
 
Name Accession Description Interval E-value
Adaptin_N pfam01602
Adaptin N terminal region; This family consists of the N terminal region of various alpha, ...
 23-180 5.37e-63

Adaptin N terminal region; This family consists of the N terminal region of various alpha, beta and gamma subunits of the AP-1, AP-2 and AP-3 adaptor protein complexes. The adaptor protein (AP) complexes are involved in the formation of clathrin-coated pits and vesicles. The N-terminal region of the various adaptor proteins (APs) is constant by comparison to the C-terminal which is variable within members of the AP-2 family; and it has been proposed that this constant region interacts with another uniform component of the coated vesicles.


Pssm-ID: 396262 [Multi-domain]  Cd Length: 523  Bit Score: 202.47  E-value: 5.37e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3413295     23 EREMIQKECAAIRSSFREEDNtYRCRNVAKLLYMHMLGNPAHFGQLECLKLIASQKFTDKRIGYLGAMLLLDERQDVHLL 102
Cdd:pfam01602   1 EEKRIQQELARILNSFRDDPR-KKKNAVKKLLYLIMLGEDISFLFFEVVKLVASKDFTLKRLGYLYLMLLAEESPDLAIL 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 3413295    103 MTNCIKNDLNHSTQFVQGLALCTLGCMGSSEMCRDLAGKVEKLLKTSNSYLKKKAALCAVHVIRKVPELMENVLPATK 180
Cdd:pfam01602  80 VTNSIQKDLQSPNQLIRGLALRTLSCIRVPELARDLAPDIKKLLVDRSPYVRKKAALAILKLYRKSPDLVRDFVPELK 157
COG5096 COG5096
Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular ...
 71-160 6.76e-07

Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 227427 [Multi-domain]  Cd Length: 757  Bit Score: 48.19  E-value: 6.76e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3413295   71 LKLIASQKFTDKRIGYLGAMLLLDERQDVHLLMTNCIKNDLNHSTQFVQGLALCTLGCMGSSEMCRDLAGKVEKLLKTSN 150
Cdd:COG5096  61 IKNVATRDVELKRLLYLYLERYAKLKPELALLAVNTIQKDLQDPNEEIRGFALRTLSLLRVKELLGNIIDPIKKLLTDPH 140

                        90
                ....*....|
gi 3413295  151 SYLKKKAALC 160
Cdd:COG5096 141 AYVRKTAALA 150
 
Name Accession Description Interval E-value
Adaptin_N pfam01602
Adaptin N terminal region; This family consists of the N terminal region of various alpha, ...
 23-180 5.37e-63

Adaptin N terminal region; This family consists of the N terminal region of various alpha, beta and gamma subunits of the AP-1, AP-2 and AP-3 adaptor protein complexes. The adaptor protein (AP) complexes are involved in the formation of clathrin-coated pits and vesicles. The N-terminal region of the various adaptor proteins (APs) is constant by comparison to the C-terminal which is variable within members of the AP-2 family; and it has been proposed that this constant region interacts with another uniform component of the coated vesicles.


Pssm-ID: 396262 [Multi-domain]  Cd Length: 523  Bit Score: 202.47  E-value: 5.37e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3413295     23 EREMIQKECAAIRSSFREEDNtYRCRNVAKLLYMHMLGNPAHFGQLECLKLIASQKFTDKRIGYLGAMLLLDERQDVHLL 102
Cdd:pfam01602   1 EEKRIQQELARILNSFRDDPR-KKKNAVKKLLYLIMLGEDISFLFFEVVKLVASKDFTLKRLGYLYLMLLAEESPDLAIL 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 3413295    103 MTNCIKNDLNHSTQFVQGLALCTLGCMGSSEMCRDLAGKVEKLLKTSNSYLKKKAALCAVHVIRKVPELMENVLPATK 180
Cdd:pfam01602  80 VTNSIQKDLQSPNQLIRGLALRTLSCIRVPELARDLAPDIKKLLVDRSPYVRKKAALAILKLYRKSPDLVRDFVPELK 157
COG5096 COG5096
Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular ...
 71-160 6.76e-07

Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 227427 [Multi-domain]  Cd Length: 757  Bit Score: 48.19  E-value: 6.76e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3413295   71 LKLIASQKFTDKRIGYLGAMLLLDERQDVHLLMTNCIKNDLNHSTQFVQGLALCTLGCMGSSEMCRDLAGKVEKLLKTSN 150
Cdd:COG5096  61 IKNVATRDVELKRLLYLYLERYAKLKPELALLAVNTIQKDLQDPNEEIRGFALRTLSLLRVKELLGNIIDPIKKLLTDPH 140

                        90
                ....*....|
gi 3413295  151 SYLKKKAALC 160
Cdd:COG5096 141 AYVRKTAALA 150
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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