|
Name |
Accession |
Description |
Interval |
E-value |
| PolY_Pol_V_umuC |
cd01700 |
umuC subunit of DNA Polymerase V; umuC subunit of Pol V. Pol V is a bacterial translesion ... |
6-355 |
5.52e-155 |
|
umuC subunit of DNA Polymerase V; umuC subunit of Pol V. Pol V is a bacterial translesion synthesis (TLS) polymerase that consists of the heterotrimer of one umuC and two umuD subunits. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Pol V, RecA, single stranded DNA-binding protein, beta sliding clamp, and gamma clamp loading complex are responsible for inducing the SOS response in bacteria to repair UV-induced DNA damage.
Pssm-ID: 176454 [Multi-domain] Cd Length: 344 Bit Score: 441.99 E-value: 5.52e-155
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800683915 6 ALIDGNSFYCSCERVFDPKLAGVPVIVLSNNDGCAVARTAEAKALGIRMGEPWFKIQALCKREGVRAFSSNYTLYGDMSA 85
Cdd:cd01700 1 ALVDCNSFYASCERVFRPLLLGRPLVVLSNNDGCVIARSPEAKALGIKMGSPYFKVPDLLERHGVAVFSSNYALYGDMSR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800683915 86 RANAVYRDFAPRVEIYSIDESFLDISDVR-EDRRRELAHDLRATVRAWTGIPTCVGIGPTKTLAKLANHIAKTIPELRGV 164
Cdd:cd01700 81 RIMSILERFSPDVEVYSIDESFLDLTGSLrFGDLEELARKIRRRILQETGIPVTVGIGPTKTLAKLANDLAKKKNPYGGV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800683915 165 CDLSDEDERAAWLCRIHVGEVWGIGRASLAKLEAMGVDSVADLRDLDPRPVRKAMTVVGERIIHELRGLACLPLEELPAQ 244
Cdd:cd01700 161 VDLTDEEVRDKLLKILPVGDVWGIGRRTAKKLNAMGIHTAGDLAQADPDLLRKKFGVVGERLVRELNGIDCLPLEEYPPP 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800683915 245 RKGCAVTRSFSRRIEDRETMEQAVSAHATRLGEKLRRGGLGTTHVTVFYHTSEHDRGDPmrSVSTTITLPEATNDTLALI 324
Cdd:cd01700 241 KKSIGSSRSFGRDVTDLDELKQALAEYAERAAEKLRRQKSVARTISVFIGTSGFSRQPK--YYSATNTLPYPTNDTREIV 318
|
330 340 350
....*....|....*....|....*....|.
gi 1800683915 325 RAARAGVAKTWReaPGDrpwRFSKAGIITTD 355
Cdd:cd01700 319 KAALRLLYAIYR--PGY---AYRKAGVMLSD 344
|
|
| umuC |
PRK03609 |
translesion error-prone DNA polymerase V subunit UmuC; |
6-429 |
3.48e-132 |
|
translesion error-prone DNA polymerase V subunit UmuC;
Pssm-ID: 179607 [Multi-domain] Cd Length: 422 Bit Score: 387.20 E-value: 3.48e-132
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800683915 6 ALIDGNSFYCSCERVFDPKLAGVPVIVLSNNDGCAVARTAEAKALGIRMGEPWFKIQALCKREGVRAFSSNYTLYGDMSA 85
Cdd:PRK03609 3 ALCDVNSFYASCETVFRPDLRGKPVVVLSNNDGCVIARSAEAKALGIKMGDPWFKQKDLFRRCGVVCFSSNYELYADMSN 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800683915 86 RANAVYRDFAPRVEIYSIDESFLDISDVREDRRRE-LAHDLRATVRAWTGIPTCVGIGPTKTLAKLANHIAKT-IPELRG 163
Cdd:PRK03609 83 RVMSTLEELSPRVEIYSIDEAFCDLTGVRNCRDLTdFGREIRATVLQRTHLTVGVGIAQTKTLAKLANHAAKKwQRQTGG 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800683915 164 VCDLSDEDERAAWLCRIHVGEVWGIGRASLAKLEAMGVDSVADLRDLDPRPVRKAMTVVGERIIHELRGLACLPLEELPA 243
Cdd:PRK03609 163 VVDLSNLERQRKLLSLQPVEEVWGVGRRISKKLNAMGIKTALDLADTNIRFIRKHFNVVLERTVRELRGEPCLSLEEFAP 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800683915 244 QRKGCAVTRSFSRRIEDRETMEQAVSAHATRLGEKLRRGGLGTTHVTVFYHTSEHDRGDPMRSVSTTITLPEATNDTLAL 323
Cdd:PRK03609 243 TKQEIVCSRSFGERITDYESMRQAICSYAARAAEKLRGEHQYCRFISTFVKTSPFALNEPYYGNSASVKLLTPTQDSRDI 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800683915 324 IRAARAGVAKTWREApgdrpWRFSKAGIITTDLAPLEDGQRALIGQLD-RERSAPLMAAMDECNRRFGRGAVVPARAGLE 402
Cdd:PRK03609 323 IAAATRALDAIWRDG-----HRYQKAGVMLGDFFSQGVAQLNLFDDNApRPGSEQLMKVLDTLNAKSGKGTLYFAGQGIA 397
|
410 420
....*....|....*....|....*..
gi 1800683915 403 akRTWSTKFEMRSPRYTTQVSELPTAR 429
Cdd:PRK03609 398 --QQWQMKREMLSPRYTTRWSDLLRVK 422
|
|
| DinP |
COG0389 |
Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination ... |
3-337 |
1.18e-114 |
|
Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination and repair];
Pssm-ID: 440158 [Multi-domain] Cd Length: 336 Bit Score: 339.04 E-value: 1.18e-114
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800683915 3 RAIALIDGNSFYCSCERVFDPKLAGVPVIVLS-NNDGCAVARTAEAKALGIRMGEPWFKIQALCKreGVRAFSSNYTLYG 81
Cdd:COG0389 1 RRILHVDMDAFYASVEQRDRPELRGKPVAVGGdNNRGVVAAASYEARAFGVRSGMPLFQARRLCP--DLVVLPPDFELYR 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800683915 82 DMSARANAVYRDFAPRVEIYSIDESFLDISDVREDRR--RELAHDLRATVRAWTGIPTCVGIGPTKTLAKLANHIAKTip 159
Cdd:COG0389 79 DVSRRVMAILERYTPLVEPLSIDEAFLDVTGSARLFGsaEAIARRIRRRIRRETGLTVSVGIAPNKFLAKIASDLAKP-- 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800683915 160 elRGVCDLSDEDERAAwLCRIHVGEVWGIGRASLAKLEAMGVDSVADLRDLDPRPVRKAMTVVGERIIHELRGLACLPLE 239
Cdd:COG0389 157 --DGLTVIPPGEVAAF-LAPLPVEKLWGVGPKTAEKLARLGIRTIGDLAALPRAELRRRFGKVGERLYRLARGIDPRPVE 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800683915 240 ELPAqRKGCAVTRSFSRRIEDRETMEQAVSAHATRLGEKLRRGGLGTTHVTVFYHTSehdrgdPMRSVSTTITLPEATND 319
Cdd:COG0389 234 PRRP-RKSIGVERTFGEDLTDLEELEAALRRLAERLAERLRRQGLGARTVTVKLRTS------DFRTTTRSRTLPEPTDD 306
|
330
....*....|....*...
gi 1800683915 320 TLALIRAARAGVAKTWRE 337
Cdd:COG0389 307 TAELLRAARELLERIYRP 324
|
|
| IMS |
pfam00817 |
impB/mucB/samB family; These proteins are involved in UV protection (Swiss). |
8-151 |
7.36e-40 |
|
impB/mucB/samB family; These proteins are involved in UV protection (Swiss).
Pssm-ID: 425885 [Multi-domain] Cd Length: 148 Bit Score: 139.63 E-value: 7.36e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800683915 8 IDGNSFYCSCERVFDPKLAGVPVIVLSNN-DGCAVARTAEAKALGIRMGEPWFKIQALCKRegVRAFSSNYTLYGDMSAR 86
Cdd:pfam00817 1 IDMDAFFASVELLRDPELKGKPVAVGGGNgRGIVAAASYEARKYGVRSGMPVFEAKKLCPN--LIVVPPDLELYRRASRK 78
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1800683915 87 ANAVYRDF-APRVEIYSIDESFLDISDVREDRR--RELAHDLRATVRAWTGIPTCVGIGPTKTLAKLA 151
Cdd:pfam00817 79 IFEILRRFsTPKVEQASIDEAFLDLTGLEKLFGaeEALAKRLRREIAEETGLTCSIGIAPNKLLAKLA 146
|
|
| DUF4113 |
pfam13438 |
Domain of unknown function (DUF4113); Although the function is not known this domain occurs ... |
378-428 |
8.60e-17 |
|
Domain of unknown function (DUF4113); Although the function is not known this domain occurs almost invariably at the very C-terminus of the IMS family DNA-polymerase repair proteins, IMS, pfam00817.
Pssm-ID: 463876 [Multi-domain] Cd Length: 49 Bit Score: 73.67 E-value: 8.60e-17
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 1800683915 378 LMAAMDECNRRFGRGAVVPARAGLeaKRTWSTKFEMRSPRYTTQVSELPTA 428
Cdd:pfam13438 1 LMAALDAINRRYGRGTVRLAAQGL--KRDWKMRREHLSPRYTTRWDELPVV 49
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PolY_Pol_V_umuC |
cd01700 |
umuC subunit of DNA Polymerase V; umuC subunit of Pol V. Pol V is a bacterial translesion ... |
6-355 |
5.52e-155 |
|
umuC subunit of DNA Polymerase V; umuC subunit of Pol V. Pol V is a bacterial translesion synthesis (TLS) polymerase that consists of the heterotrimer of one umuC and two umuD subunits. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Pol V, RecA, single stranded DNA-binding protein, beta sliding clamp, and gamma clamp loading complex are responsible for inducing the SOS response in bacteria to repair UV-induced DNA damage.
Pssm-ID: 176454 [Multi-domain] Cd Length: 344 Bit Score: 441.99 E-value: 5.52e-155
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800683915 6 ALIDGNSFYCSCERVFDPKLAGVPVIVLSNNDGCAVARTAEAKALGIRMGEPWFKIQALCKREGVRAFSSNYTLYGDMSA 85
Cdd:cd01700 1 ALVDCNSFYASCERVFRPLLLGRPLVVLSNNDGCVIARSPEAKALGIKMGSPYFKVPDLLERHGVAVFSSNYALYGDMSR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800683915 86 RANAVYRDFAPRVEIYSIDESFLDISDVR-EDRRRELAHDLRATVRAWTGIPTCVGIGPTKTLAKLANHIAKTIPELRGV 164
Cdd:cd01700 81 RIMSILERFSPDVEVYSIDESFLDLTGSLrFGDLEELARKIRRRILQETGIPVTVGIGPTKTLAKLANDLAKKKNPYGGV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800683915 165 CDLSDEDERAAWLCRIHVGEVWGIGRASLAKLEAMGVDSVADLRDLDPRPVRKAMTVVGERIIHELRGLACLPLEELPAQ 244
Cdd:cd01700 161 VDLTDEEVRDKLLKILPVGDVWGIGRRTAKKLNAMGIHTAGDLAQADPDLLRKKFGVVGERLVRELNGIDCLPLEEYPPP 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800683915 245 RKGCAVTRSFSRRIEDRETMEQAVSAHATRLGEKLRRGGLGTTHVTVFYHTSEHDRGDPmrSVSTTITLPEATNDTLALI 324
Cdd:cd01700 241 KKSIGSSRSFGRDVTDLDELKQALAEYAERAAEKLRRQKSVARTISVFIGTSGFSRQPK--YYSATNTLPYPTNDTREIV 318
|
330 340 350
....*....|....*....|....*....|.
gi 1800683915 325 RAARAGVAKTWReaPGDrpwRFSKAGIITTD 355
Cdd:cd01700 319 KAALRLLYAIYR--PGY---AYRKAGVMLSD 344
|
|
| umuC |
PRK03609 |
translesion error-prone DNA polymerase V subunit UmuC; |
6-429 |
3.48e-132 |
|
translesion error-prone DNA polymerase V subunit UmuC;
Pssm-ID: 179607 [Multi-domain] Cd Length: 422 Bit Score: 387.20 E-value: 3.48e-132
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800683915 6 ALIDGNSFYCSCERVFDPKLAGVPVIVLSNNDGCAVARTAEAKALGIRMGEPWFKIQALCKREGVRAFSSNYTLYGDMSA 85
Cdd:PRK03609 3 ALCDVNSFYASCETVFRPDLRGKPVVVLSNNDGCVIARSAEAKALGIKMGDPWFKQKDLFRRCGVVCFSSNYELYADMSN 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800683915 86 RANAVYRDFAPRVEIYSIDESFLDISDVREDRRRE-LAHDLRATVRAWTGIPTCVGIGPTKTLAKLANHIAKT-IPELRG 163
Cdd:PRK03609 83 RVMSTLEELSPRVEIYSIDEAFCDLTGVRNCRDLTdFGREIRATVLQRTHLTVGVGIAQTKTLAKLANHAAKKwQRQTGG 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800683915 164 VCDLSDEDERAAWLCRIHVGEVWGIGRASLAKLEAMGVDSVADLRDLDPRPVRKAMTVVGERIIHELRGLACLPLEELPA 243
Cdd:PRK03609 163 VVDLSNLERQRKLLSLQPVEEVWGVGRRISKKLNAMGIKTALDLADTNIRFIRKHFNVVLERTVRELRGEPCLSLEEFAP 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800683915 244 QRKGCAVTRSFSRRIEDRETMEQAVSAHATRLGEKLRRGGLGTTHVTVFYHTSEHDRGDPMRSVSTTITLPEATNDTLAL 323
Cdd:PRK03609 243 TKQEIVCSRSFGERITDYESMRQAICSYAARAAEKLRGEHQYCRFISTFVKTSPFALNEPYYGNSASVKLLTPTQDSRDI 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800683915 324 IRAARAGVAKTWREApgdrpWRFSKAGIITTDLAPLEDGQRALIGQLD-RERSAPLMAAMDECNRRFGRGAVVPARAGLE 402
Cdd:PRK03609 323 IAAATRALDAIWRDG-----HRYQKAGVMLGDFFSQGVAQLNLFDDNApRPGSEQLMKVLDTLNAKSGKGTLYFAGQGIA 397
|
410 420
....*....|....*....|....*..
gi 1800683915 403 akRTWSTKFEMRSPRYTTQVSELPTAR 429
Cdd:PRK03609 398 --QQWQMKREMLSPRYTTRWSDLLRVK 422
|
|
| DinP |
COG0389 |
Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination ... |
3-337 |
1.18e-114 |
|
Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination and repair];
Pssm-ID: 440158 [Multi-domain] Cd Length: 336 Bit Score: 339.04 E-value: 1.18e-114
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800683915 3 RAIALIDGNSFYCSCERVFDPKLAGVPVIVLS-NNDGCAVARTAEAKALGIRMGEPWFKIQALCKreGVRAFSSNYTLYG 81
Cdd:COG0389 1 RRILHVDMDAFYASVEQRDRPELRGKPVAVGGdNNRGVVAAASYEARAFGVRSGMPLFQARRLCP--DLVVLPPDFELYR 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800683915 82 DMSARANAVYRDFAPRVEIYSIDESFLDISDVREDRR--RELAHDLRATVRAWTGIPTCVGIGPTKTLAKLANHIAKTip 159
Cdd:COG0389 79 DVSRRVMAILERYTPLVEPLSIDEAFLDVTGSARLFGsaEAIARRIRRRIRRETGLTVSVGIAPNKFLAKIASDLAKP-- 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800683915 160 elRGVCDLSDEDERAAwLCRIHVGEVWGIGRASLAKLEAMGVDSVADLRDLDPRPVRKAMTVVGERIIHELRGLACLPLE 239
Cdd:COG0389 157 --DGLTVIPPGEVAAF-LAPLPVEKLWGVGPKTAEKLARLGIRTIGDLAALPRAELRRRFGKVGERLYRLARGIDPRPVE 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800683915 240 ELPAqRKGCAVTRSFSRRIEDRETMEQAVSAHATRLGEKLRRGGLGTTHVTVFYHTSehdrgdPMRSVSTTITLPEATND 319
Cdd:COG0389 234 PRRP-RKSIGVERTFGEDLTDLEELEAALRRLAERLAERLRRQGLGARTVTVKLRTS------DFRTTTRSRTLPEPTDD 306
|
330
....*....|....*...
gi 1800683915 320 TLALIRAARAGVAKTWRE 337
Cdd:COG0389 307 TAELLRAARELLERIYRP 324
|
|
| PolY_Pol_IV_kappa |
cd03586 |
DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion ... |
8-339 |
1.99e-54 |
|
DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Known primarily as Pol IV in prokaryotes and Pol kappa in eukaryotes, this polymerase has a propensity for generating frameshift mutations. The eukaryotic Pol kappa differs from Pol IV and Dpo4 by an N-terminal extension of ~75 residues known as the "N-clasp" region. The structure of Pol kappa shows DNA that is almost totally encircled by Pol kappa, with the N-clasp region augmenting the interactions between DNA and the polymerase. Pol kappa is more resistant than Pol eta and Pol iota to bulky guanine adducts and is efficient at catalyzing the incorporation of dCTP. Bacterial pol IV has a higher error rate than other Y-family polymerases.
Pssm-ID: 176459 [Multi-domain] Cd Length: 334 Bit Score: 183.88 E-value: 1.99e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800683915 8 IDGNSFYCSCERVFDPKLAGVPVIVLSNNDGCAVArTA--EAKALGIRMGEPWFKIQALCKREGVraFSSNYTLYGDMSA 85
Cdd:cd03586 3 IDMDAFYASVEQRDNPELKGKPVAVGGSSDRGVVS-TAsyEARKFGVRSAMPIFQAKKLCPNLIF--VPPRFDKYREVSR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800683915 86 RANAVYRDFAPRVEIYSIDESFLDISDVREDRR--RELAHDLRATVRAWTGIPTCVGIGPTKTLAKLANHIAKtiPelRG 163
Cdd:cd03586 80 QIMEILREYTPLVEPLSIDEAYLDVTDYVRLFGsaTEIAKEIRARIREETGLTASAGIAPNKFLAKIASDLNK--P--NG 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800683915 164 VCDLSDEDErAAWLCRIHVGEVWGIGRASLAKLEAMGVDSVADLRDLDPRPVRKAMTVVGERIIHELRGLACLPLEElPA 243
Cdd:cd03586 156 LTVIPPEDV-EEFLAPLPVRKIPGVGKVTAEKLKELGIKTIGDLAKLDVELLKKLFGKSGRRLYELARGIDNRPVEP-DR 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800683915 244 QRKGCAVTRSFSRRIEDRETMEQAVSAHATRLGEKLRRGGLG--TTHVTVFYHTsehdrgdpMRSVSTTITLPEATNDTL 321
Cdd:cd03586 234 ERKSIGVERTFSEDLTDPEELLEELLELAEELAERLRKRGLKgrTVTVKLKYAD--------FSTRTRSRTLPEPTDDAE 305
|
330
....*....|....*...
gi 1800683915 322 ALIRAARAGVAKTWREAP 339
Cdd:cd03586 306 DIYELALELLEELLDGRP 323
|
|
| PolY |
cd00424 |
Y-family of DNA polymerases; Y-family DNA polymerases are a specialized subset of polymerases ... |
8-345 |
5.02e-51 |
|
Y-family of DNA polymerases; Y-family DNA polymerases are a specialized subset of polymerases that facilitate translesion synthesis (TLS), a process that allows the bypass of a variety of DNA lesions. Unlike replicative polymerases, TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. The active sites of TLS polymerases are large and flexible to allow the accomodation of distorted bases. Most TLS polymerases are members of the Y-family, including Pol eta, Pol kappa/IV, Pol iota, Rev1, and Pol V, which is found exclusively in bacteria. In eukaryotes, the B-family polymerase Pol zeta also functions as a TLS polymerase. Expression of Y-family polymerases is often induced by DNA damage and is believed to be highly regulated. TLS is likely induced by the monoubiquitination of the replication clamp PCNA, which provides a scaffold for TLS polymerases to bind in order to access the lesion. Because of their high error rates, TLS polymerases are potential targets for cancer treatment and prevention.
Pssm-ID: 176453 [Multi-domain] Cd Length: 343 Bit Score: 175.24 E-value: 5.02e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800683915 8 IDGNSFYCSCERVFDPKLAGVPVIVLSNND--GCAVARTAEAKALGIRMGEPWFKIQALCKREGVRAfsSNYTLYGDMSA 85
Cdd:cd00424 3 IDFDNFFASVEQLARPELKGRPVVVVPFNSdsTCVIACSYEARKYGVKRGMPVREARKMCPNLILVP--ARLDLYRRLSE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800683915 86 RANAVYRDFAPRVEIYSIDESFLDISDVREDRR--RELAHDLRATVRAWTG-IPTCVGIGPTKTLAKLANHIAKtiPElr 162
Cdd:cd00424 81 RLLSELEEVAPLVEVASIDELFLDLTGSARLLGlgSEVALRIKRHIAEQLGgITASIGIASNKLLAKLAAKYAK--PD-- 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800683915 163 GVCDLSDEDERAAWLcRIHVGEVWGIGRASLAKLEAMGVDSVADLRDLDPR-PVRKAMTVVGERIIHELRGLACLPLEEl 241
Cdd:cd00424 157 GLTILDPEDLPGFLS-KLPLTDLPGIGAVTAKRLEAVGINPIGDLLAASPDaLLALWGGVSGERLWYALRGIDDEPLSP- 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800683915 242 PAQRKGCAVTRSFSRRIEDRETMEQAVSAHATRLGEKLRRGGLGTT--HVTVFYHTSEHDRGDPMRSVSTTITLPEATND 319
Cdd:cd00424 235 PRPRKSFSHERVLPRDSRNAEDARPLLRLLLEKLARRLRRDGRGATrlRLWLRTVDGRWSGHADIPSRSAPRPISTEDGE 314
|
330 340
....*....|....*....|....*.
gi 1800683915 320 TLALIRaaragvaKTWREAPGDRPWR 345
Cdd:cd00424 315 LLHALD-------KLWRALLDDKGPR 333
|
|
| PRK03103 |
PRK03103 |
DNA polymerase IV; Reviewed |
1-403 |
5.27e-45 |
|
DNA polymerase IV; Reviewed
Pssm-ID: 235104 [Multi-domain] Cd Length: 409 Bit Score: 161.32 E-value: 5.27e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800683915 1 MTRAIALIDGNSFYCSCERVFDPKLAGVPVIVL---SNNDGCAVARTAEAKALGIRMGEPWFKIQALCkREGVrAFSSNY 77
Cdd:PRK03103 1 MERVILLVDMQSFYASVEKAANPELKGRPVIVSgdpERRSGVVLAACPLAKAYGVKTAERLWEAQQKC-PDLV-VVKPRM 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800683915 78 TLYGDMSARANAVYRDFAPRVEIYSIDESFLDISDVRE--DRRRELAHDLRATVRAWTGIPTCVGIGPTKTLAKLA-NHI 154
Cdd:PRK03103 79 QRYIDVSLQITRILEDFTDLVEPFSIDEQFLDVTGSQKlfGSPLEIAQKIQQRIMRETGVYARVGIGPNKLLAKMAcDNF 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800683915 155 AKTIPElrGVCDLSDEDERAA-WLCRihVGEVWGIGRASLAKLEAMGVDSVADLRDLDPRPVRKAMTVVGERIIHELRGL 233
Cdd:PRK03103 159 AKKNPD--GLFTLDKEDVPADlWPLP--VRKLFGVGSRMEKHLRRMGIRTIGQLANTPLERLKKRWGINGEVLWRTANGI 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800683915 234 ACLPLE-ELPAQRKGCAVTRSFSRRIEDRETMEQAVSAHATRLGEKLRRGG-LGTThVTVFYHTSEHDRGdpmRSVSTTI 311
Cdd:PRK03103 235 DYSPVTpHSLDRQKAIGHQMTLPRDYRGFEEIKVVLLELCEEVCRRARAKGyMGRT-VSVSLRGADFDWP---TGFSRQM 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800683915 312 TLPEATNDTLALIRAARAGVAKTWREapgdRPWRfsKAGIITTDLAPLEDGQRALIGqlDRERSAPLMAAMDECNRRFGR 391
Cdd:PRK03103 311 TLPEPTNLAMEVYEAACKLFHRHWDG----KPVR--RVGVTLSNLVSDDVWQLSLFG--DRERKRSLGYVMDDIKNRFGP 382
|
410
....*....|..
gi 1800683915 392 GAVVPARAGLEA 403
Cdd:PRK03103 383 TAILRASSLTEA 394
|
|
| IMS |
pfam00817 |
impB/mucB/samB family; These proteins are involved in UV protection (Swiss). |
8-151 |
7.36e-40 |
|
impB/mucB/samB family; These proteins are involved in UV protection (Swiss).
Pssm-ID: 425885 [Multi-domain] Cd Length: 148 Bit Score: 139.63 E-value: 7.36e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800683915 8 IDGNSFYCSCERVFDPKLAGVPVIVLSNN-DGCAVARTAEAKALGIRMGEPWFKIQALCKRegVRAFSSNYTLYGDMSAR 86
Cdd:pfam00817 1 IDMDAFFASVELLRDPELKGKPVAVGGGNgRGIVAAASYEARKYGVRSGMPVFEAKKLCPN--LIVVPPDLELYRRASRK 78
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1800683915 87 ANAVYRDF-APRVEIYSIDESFLDISDVREDRR--RELAHDLRATVRAWTGIPTCVGIGPTKTLAKLA 151
Cdd:pfam00817 79 IFEILRRFsTPKVEQASIDEAFLDLTGLEKLFGaeEALAKRLRREIAEETGLTCSIGIAPNKLLAKLA 146
|
|
| PRK03858 |
PRK03858 |
DNA polymerase IV; Validated |
9-397 |
7.85e-36 |
|
DNA polymerase IV; Validated
Pssm-ID: 179663 [Multi-domain] Cd Length: 396 Bit Score: 135.88 E-value: 7.85e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800683915 9 DGNSFYCSCERVFDPKLAGVPVIVlsnNDGCAVARTAEAKALGIRMGEPWFKIQALCKREGVraFSSNYTLYGDMSARAN 88
Cdd:PRK03858 10 DLDSFYASVEQRDDPALRGRPVIV---GGGVVLAASYEAKAYGVRTAMGGRQARRLCPQAVV--VPPRMSAYSRASKAVF 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800683915 89 AVYRDFAPRVEIYSIDESFLDISDVRE--DRRRELAHDLRATVRAWTGIPTCVGIGPTKTLAKLANHIAKtiPE-LRGVc 165
Cdd:PRK03858 85 EVFRDTTPLVEGLSIDEAFLDVGGLRRisGTPVQIAARLRRRVREEVGLPITVGVARTKFLAKVASQVAK--PDgLLVV- 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800683915 166 dlsDEDERAAWLCRIHVGEVWGIGRASLAKLEAMGVDSVADLRDLDPRPVRKamtVVGERIIHELRGLACL--PLEELPA 243
Cdd:PRK03858 162 ---PPDRELAFLHPLPVRRLWGVGPVTAAKLRAHGITTVGDVAELPESALVS---LLGPAAGRHLHALAHNrdPRRVETG 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800683915 244 QRKGCA-VTRSFSRRIEDRETMEQAVSAHATRLGEKLRRGGLGTTHVTVfyhtseHDRGDPMRSVSTTITLPEATNDTLA 322
Cdd:PRK03858 236 RRRRSVgAQRALGRGPNSPAEVDAVVVALVDRVARRMRAAGRTGRTVVL------RLRFDDFTRATRSHTLPRPTASTAT 309
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1800683915 323 LIRAARAGVAKTWREAPgDRPwrFSKAGIITTDLAPlEDGQRALIGQLDRERSAPLMAAMDECNRRFGRGAVVPA 397
Cdd:PRK03858 310 LLAAARDLVAAAAPLIA-ERG--LTLVGFAVSNLDD-DGAQQLELPFGLRRPGSALDAALDAVRDRFGNAAVTRA 380
|
|
| PRK03348 |
PRK03348 |
DNA polymerase IV; Provisional |
1-329 |
4.57e-32 |
|
DNA polymerase IV; Provisional
Pssm-ID: 235118 [Multi-domain] Cd Length: 454 Bit Score: 126.59 E-value: 4.57e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800683915 1 MTRAIALIDGNSFYCSCERVFDPKLAGVPVIV--LSnndGCAVARTA--EAKALGIRMGEPWFKIQALCkreGVRA--FS 74
Cdd:PRK03348 3 AQRWVLHLDMDAFFASVEQLTRPTLRGRPVLVggLG---GRGVVAGAsyEARVFGARSAMPMHQARRLV---GNGAvvLP 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800683915 75 SNYTLYGDMSARANAVYRDFAPRVEIYSIDESFLDISDVR---EDRRRELAHDLRATVRAWTGIPTCVGIGPTKTLAKLA 151
Cdd:PRK03348 77 PRFVVYRAASRRVFDTLRELSPVVEQLSFDEAFVEPAELAgasAEEVEAFAERLRARVREETGLPASVGAGSGKQIAKIA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800683915 152 NHIAKtiPElrGVCDLSDEDERAAwLCRIHVGEVWGIGRASLAKLEAMGVDSVADLRDLDPRPVRKAM-TVVGERIIHEL 230
Cdd:PRK03348 157 SGLAK--PD--GIRVVPPGEEREL-LAPLPVRRLWGIGPVTEEKLHRLGIETIGDLAALSEAEVANLLgATVGPALHRLA 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800683915 231 RGLACLPLEElPAQRKGCAVTRSFSRRIEDRETMEQAVSAHATRLGEKLRRGGLGTTHVTVFYHTSEhdrgdpMRSVSTT 310
Cdd:PRK03348 232 RGIDDRPVAE-RAEAKQISAESTFAVDLTTRAQLREAIERIAEHAHRRLLKDGRGARTVTVKLRKSD------FSTLTRS 304
|
330
....*....|....*....
gi 1800683915 311 ITLPEATNDTLALIRAARA 329
Cdd:PRK03348 305 ATLPYATDDAAVLAATARR 323
|
|
| PRK01810 |
PRK01810 |
DNA polymerase IV; Validated |
3-412 |
7.74e-32 |
|
DNA polymerase IV; Validated
Pssm-ID: 179337 [Multi-domain] Cd Length: 407 Bit Score: 125.14 E-value: 7.74e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800683915 3 RAIALIDGNSFYCSCERVFDPKLAGVPVIVLSN---NDGCAVARTAEAKALGIRMGEPWFKIQALCKREGVRafSSNYTL 79
Cdd:PRK01810 5 RVIFHVDMNSFFASVEIAYDPSLQGKPLAVAGNekeRKGIIVTCSYEARAYGIRTTMPLWEAKRLCPQLIVR--RPNFDR 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800683915 80 YGDMSARANAVYRDFAPRVEIYSIDESFLDISDVREDRRR-ELAHDLRATVRAWTGIPTCVGIGPTKTLAKLANHIAK-- 156
Cdd:PRK01810 83 YREASRQMFQILSEFTPLVQPVSIDEGYLDITDCYALGSPlEIAKMIQQRLLTELQLPCSIGIAPNKFLAKMASDMKKpl 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800683915 157 --TIPELRGVCDLsdederaawLCRIHVGEVWGIGRASLAKLEAMGVDSVADLRDLDPRPVRKAMTVVGERIIHELRGLA 234
Cdd:PRK01810 163 giTVLRKRDVPEM---------LWPLPVGEMHGIGEKTAEKLKDIGIQTIGDLAKADEHILRAKLGINGVRLQRRANGID 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800683915 235 CLPLE-ELPAQRKGCAVTRSFSRRIEDRETMEQAVSAHATRLGEKLRRGGLGTthVTVFYHTSEHDRgdpmRSVSTTITL 313
Cdd:PRK01810 234 DRPVDpEAIYQFKSVGNSTTLSHDMDEEKELLDVLRRLSKSVSKRLQKKTVVS--YNVQIMIRYHDR----RTITRSKTL 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800683915 314 PEATNDTLALIRAARAGVAKTWREapgdRPWRFskAGIITTDlapLEDgQRALIGQLD------RERSAPLMAAMDECNR 387
Cdd:PRK01810 308 KNPIWEKRDIFQAASRLFKQHWNG----DPVRL--LGVTATD---LEW-KTEAVKQLDlfsfeeDAKEEPLLAVIDQIND 377
|
410 420
....*....|....*....|....*....
gi 1800683915 388 RFGRGAVvpaRAGLEAKR----TWSTKFE 412
Cdd:PRK01810 378 KYGMPLL---QRGSQLLRkqekTFGTSFE 403
|
|
| PRK02794 |
PRK02794 |
DNA polymerase IV; Provisional |
4-399 |
1.67e-28 |
|
DNA polymerase IV; Provisional
Pssm-ID: 179473 [Multi-domain] Cd Length: 419 Bit Score: 116.18 E-value: 1.67e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800683915 4 AIALIDGNSFYCSCERVFDPKLAGVPVIVLSNNDG-----CAVARTAeakalGIRMGEPWFKIQALCKREGVraFSSNYT 78
Cdd:PRK02794 37 SIAHIDCDAFYASVEKRDNPELRDKPVIIGGGKRGvvstaCYIARIH-----GVRSAMPMFKALKLCPDAVV--IKPDME 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800683915 79 LYGDMSARANAVYRDFAPRVEIYSIDESFLDISDVreDRR------RELAHdLRATVRAWTGIPTCVGIGPTKTLAKLAN 152
Cdd:PRK02794 110 KYVRVGREVRAMMQALTPLVEPLSIDEAFLDLSGT--ERLhgappaVVLAR-FARRVEREIGITVSVGLSYNKFLAKIAS 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800683915 153 HIAKTipelRGVCDLsDEDERAAWLCRIHVGEVWGIGRASLAKLEAMGVDSVADLRDLDPRPVRKAMTVVGERIIHELRG 232
Cdd:PRK02794 187 DLDKP----RGFSVI-GRAEALAFLAPKPVGIIWGVGPATAARLARDGIRTIGDLQRADEADLMRRFGSMGLRLWRLARG 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800683915 233 LACLPLEelPAQ-RKGCAVTRSFSRRIEDRETMEQAVSAHATRLGEKLRRGGLGTTHVTVFYHTSEHdrgdpmRSVSTTI 311
Cdd:PRK02794 262 IDDRKVS--PDReAKSVSAETTFETDLSDFEDLEPILWRLSEKVSRRLKAAGLAGRTVTLKLKTADF------RLRTRRR 333
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800683915 312 TLPEATNDTLALIRAARAGVAKtwrEAPGdRPWRfskagIITTDLAPLEDGQRALIGQL---DRERSAPLMAAMDECNRR 388
Cdd:PRK02794 334 TLEDPTQLADRIFRTARELLEK---ETDG-TAFR-----LIGIGVSDLSPADEADPPDLldpQATRRAAAERAIDALRAK 404
|
410
....*....|.
gi 1800683915 389 FGRGAVVPARA 399
Cdd:PRK02794 405 FGAAAVETGRA 415
|
|
| PRK03352 |
PRK03352 |
DNA polymerase IV; Validated |
1-345 |
7.89e-27 |
|
DNA polymerase IV; Validated
Pssm-ID: 179564 [Multi-domain] Cd Length: 346 Bit Score: 110.11 E-value: 7.89e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800683915 1 MTRAIALIDGNSFYCSCERVFDPKLAGVPVIVLSNNDGC---AVARTA--EAKALGIRMGEPwFKIQALCKREGVrAFSS 75
Cdd:PRK03352 3 MPRWVLHVDLDQFIAAVELLRRPELAGLPVIVGGNGDPTeprKVVTCAsyEARAFGVRAGMP-LRTAARRCPDAV-FLPS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800683915 76 NYTLYGDMSARANAVYRDFAPRVEIYSIDESFLDisdVREDRRRELAHDLRATVRAWTGIPTCVGIGPTKTLAKLANHIA 155
Cdd:PRK03352 81 DPAAYDAASEEVMATLRDLGVPVEVWGWDEAFLG---VDTDDPEALAEEIRAAVLERTGLSCSVGIGDNKLRAKIATGFA 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800683915 156 KTipelRGVCDLSDEDeraaWLCRIH---VGEVWGIGRASLAKLEAMGVDSVADLRDLDPRPVRKAM-TVVGERIIHELR 231
Cdd:PRK03352 158 KP----AGVFRLTDAN----WMAVMGdrpTDALWGVGPKTAKRLAALGITTVADLAAADPAELAATFgPTTGPWLLLLAR 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800683915 232 GLACLPLEELPAQRKGCAVTRSFSRRIEDRETMEQAVSAHATRLGEKLRRGGLGTTHVTVFYHTSehdrgdPMRSVSTTI 311
Cdd:PRK03352 230 GGGDTEVSAEPWVPRSRSREVTFPQDLTDRAEVESAVRELARRVLDEVVAEGRPVTRVAVKVRTA------TFYTRTKIR 303
|
330 340 350
....*....|....*....|....*....|....
gi 1800683915 312 TLPEATNDTLALIRAARAGVAKTWReapgDRPWR 345
Cdd:PRK03352 304 KLPEPTTDPDVIEAAALDVLDRFEL----DRPVR 333
|
|
| PRK14133 |
PRK14133 |
DNA polymerase IV; Provisional |
1-297 |
2.05e-25 |
|
DNA polymerase IV; Provisional
Pssm-ID: 184529 [Multi-domain] Cd Length: 347 Bit Score: 106.34 E-value: 2.05e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800683915 1 MTRAIALIDGNSFYCSCERVFDPKLAGVPVIV--LSNNdgcAVARTA--EAKALGIRMGEPWFKIQALCKrEGVrAFSSN 76
Cdd:PRK14133 1 MDRVIIHVDMDAFFASVEQMDNPKLKGKPVIVggISER---GVVSTCsyEARKYGVHSAMPVFMAKKRCP-HGI-FLPVR 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800683915 77 YTLYGDMSARANAVYRDFAPRVEIYSIDESFLDISDVREDrRRELAHDLRATVRAWTGIPTCVGIGPTKTLAKLANHIAK 156
Cdd:PRK14133 76 HERYKEVSKNIFKILYEVTPIVEPVSIDEAYLDITNIKEE-PIKIAKYIKKKVKKETGLTLSVGISYNKFLAKLASDWNK 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800683915 157 tiPElrGVCDLSdEDERAAWLCRIHVGEVWGIGRASLAKLEAMGVDSVADLRDLDPRPVRKAMTVVGERIIHELRGLACL 236
Cdd:PRK14133 155 --PD--GIKIIT-EDMIPDILKPLPISKVHGIGKKSVEKLNNIGIYTIEDLLKLSREFLIEYFGKFGVEIYERIRGIDYR 229
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1800683915 237 PLeELPAQRKGCAVTRSFSRRIEDRETMEQAVSAHATRLGEKLRRGGLGTTHVTVFYHTSE 297
Cdd:PRK14133 230 EV-EVSRERKSIGKETTLKKDTKDKEELKKYLKDFSNIISEELKKRNLYGKTVTVKIKTSD 289
|
|
| PRK01216 |
PRK01216 |
DNA polymerase IV; Validated |
5-224 |
1.66e-21 |
|
DNA polymerase IV; Validated
Pssm-ID: 179251 [Multi-domain] Cd Length: 351 Bit Score: 95.24 E-value: 1.66e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800683915 5 IALIDGNSFYCSCERVFDPKLAGVPVIVL----SNNDGCAVArTA--EAKALGIRMGEPWFKIQALCK-------REGVr 71
Cdd:PRK01216 3 ILFVDFDYFFAQVEEVLNPSLKGKPVVVCvysgRFEDSGAVA-TAnyEARKLGIKAGMPIVEAKKILPnavylpmRKEV- 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800683915 72 afssnytlYGDMSARANAVYRDFAPRVEIYSIDESFLDISDVREDRRR--ELAHDLRATVRAWTGIPTCVGIGPTKTLAK 149
Cdd:PRK01216 81 --------YQQVSNRIMKLLREYSEKIEIASIDEAYLDISDKVKNYQDayNLGLEIKNKILEKEKITVTVGISKNKVFAK 152
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1800683915 150 LANHIAKtiPELRGVCdlsDEDERAAWLCRIHVGEVWGIGRASLAKLEAMGVDSvadLRDLDPRPVRKAMTVVGE 224
Cdd:PRK01216 153 IAADMAK--PNGIKVI---DDEEVKRFINELDIADIPGIGDITAEKLKKLGVNK---LVDTLRIEFDELKGIIGE 219
|
|
| PolY_Rev1 |
cd01701 |
DNA polymerase Rev1; Rev1 is a translesion synthesis (TLS) polymerase found in eukaryotes. ... |
2-333 |
3.26e-20 |
|
DNA polymerase Rev1; Rev1 is a translesion synthesis (TLS) polymerase found in eukaryotes. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Rev1 has both structural and enzymatic roles. Structurally, it is believed to interact with other nonclassical polymerases and replication machinery to act as a scaffold. Enzymatically, it catalyzes the specific insertion of dCMP opposite abasic sites. Rev1 interacts with the Rev7 subunit of the B-family TLS polymerase Pol zeta (Rev3/Rev7). Rev1 is known to actively promote the introduction of mutations, potentially making it a significant target for cancer treatment.
Pssm-ID: 176455 [Multi-domain] Cd Length: 404 Bit Score: 91.99 E-value: 3.26e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800683915 2 TRAIALIDGNSFYCSCERVFDPKLAGVPVIVlSNNDGcavaRTAE-------AKALGIRMGEpWFKiQA--LCKRegVRA 72
Cdd:cd01701 46 QRIIMHVDFDCFFVSVSIRNRPDLKGKPVAV-CHGKG----PNSEiascnyeARSYGIKNGM-WVG-QAkkLCPQ--LVT 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800683915 73 FSSNYTLYGDMSARANAVYRDFAPRVEIYSIDESFLDISDVREDRR---RELAHDLRATVRAWTGIPTCVGIGPTKTLAK 149
Cdd:cd01701 117 LPYDFEAYEEVSLTFYEILASYTDNIEAVSCDEALIDITSLLEETYelpEELAEAIRNEIRETTGCSASVGIGPNILLAR 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800683915 150 LANHIAKtiPElrGVCDLSDEDErAAWLCRIHVGEVWGIGRASLAKLEAMGVDSVADLRdLDPRPVRKAMTVVGER---- 225
Cdd:cd01701 197 LATRKAK--PD--GQYHLSAEKV-EEFLSQLKVGDLPGVGSSLAEKLVKLFGDTCGGLE-LRSKTKEKLQKVLGPKtgek 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800683915 226 IIHELRGLACLPLEElPAQRKGCAVTRSFSRRIEDRETMEQAVSAHATRLGEKLRRGGLGTTHVTVfyHTSEHDRGDPMR 305
Cdd:cd01701 271 LYDYCRGIDDRPVTG-EKERKSVSAEINYGIRFTNVDDVEQFLQRLSEELSKRLEESNVTGRQITL--KLMKRAPGAPIE 347
|
330 340 350
....*....|....*....|....*....|....*....
gi 1800683915 306 -----------SVSTTITLPEATNDTLALIRAARAGVAK 333
Cdd:cd01701 348 ppkymghgicdSFSKSSTLGVATDDSGVIGTEAKKLFRD 386
|
|
| IMS_C |
pfam11799 |
impB/mucB/samB family C-terminal domain; These proteins are involved in UV protection (Swiss). |
245-358 |
4.93e-18 |
|
impB/mucB/samB family C-terminal domain; These proteins are involved in UV protection (Swiss).
Pssm-ID: 463354 [Multi-domain] Cd Length: 104 Bit Score: 79.14 E-value: 4.93e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800683915 245 RKGCAVTRSFSRRIEDRETMEQAVSAHATRLGEKLRRGGLGTTHVTVFYHTSehdrgdPMRSVSTTITLPEATNDTLALI 324
Cdd:pfam11799 1 RKSIGAERTFGRDLTDLEELREALLELAEELAERLRRQGLVARTVTVKIRYS------DFRTITRSVTLPSPTDDTDEIY 74
|
90 100 110
....*....|....*....|....*....|....
gi 1800683915 325 RAARAGVAKTWREAPgdrpwrFSKAGIITTDLAP 358
Cdd:pfam11799 75 RAALRLLRRLYRGRP------VRLLGVSLSNLVP 102
|
|
| DUF4113 |
pfam13438 |
Domain of unknown function (DUF4113); Although the function is not known this domain occurs ... |
378-428 |
8.60e-17 |
|
Domain of unknown function (DUF4113); Although the function is not known this domain occurs almost invariably at the very C-terminus of the IMS family DNA-polymerase repair proteins, IMS, pfam00817.
Pssm-ID: 463876 [Multi-domain] Cd Length: 49 Bit Score: 73.67 E-value: 8.60e-17
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 1800683915 378 LMAAMDECNRRFGRGAVVPARAGLeaKRTWSTKFEMRSPRYTTQVSELPTA 428
Cdd:pfam13438 1 LMAALDAINRRYGRGTVRLAAQGL--KRDWKMRREHLSPRYTTRWDELPVV 49
|
|
| PRK02406 |
PRK02406 |
DNA polymerase IV; Validated |
13-283 |
2.56e-15 |
|
DNA polymerase IV; Validated
Pssm-ID: 235035 [Multi-domain] Cd Length: 343 Bit Score: 76.70 E-value: 2.56e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800683915 13 FYCSCERVFDPKLAGVPVIVLSNNDGCAVARTA--EAKALGIRMGEPwfKIQA--LCkREGVraF-SSNYTLYGDMSARA 87
Cdd:PRK02406 4 FYAAVEMRDNPELRGKPVAVGGSPGRRGVISTCnyEARKFGVRSAMP--TAQAlkLC-PDLI--FvPGRFDVYKEVSRQI 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800683915 88 NAVYRDFAPRVEIYSIDESFLDISDVREDRR--RELAHDLRATVRAWTGIpTC-VGIGPTKTLAKLAnhiaktipelrgv 164
Cdd:PRK02406 79 REIFRRYTDLIEPLSLDEAYLDVTDNKLCIGsaTLIAQEIRQDIFEELGL-TAsAGVAPNKFLAKIA------------- 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800683915 165 cdlSDE-----------DERAAWLCRIHVGEVWGIGRASLAKLEAMGVDSVADLRDLDPRPVRKAMTVVGERIIHELRGl 233
Cdd:PRK02406 145 ---SDWnkpnglfvitpEEVDAFLATLPVEKIPGVGKVTAEKLHALGIYTCADLQKYDLAELIRHFGKFGRRLYERARG- 220
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 1800683915 234 aclpLEELPAQ----RKGCAVTRSFSRRIEDRETMEQAVSAHATRLGEKLRRGG 283
Cdd:PRK02406 221 ----IDERPVKpdreRKSVGVERTFAEDLYDLEACLAELPRLAEKLERRLERAK 270
|
|
| PolY_Pol_iota |
cd01703 |
DNA Polymerase iota; Pol iota, also called Rad30B, is a translesion synthesis (TLS) polymerase. ... |
9-214 |
6.97e-11 |
|
DNA Polymerase iota; Pol iota, also called Rad30B, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Pol iota is thought to be one of the least efficient polymerases, particularly when opposite pyrimidines; it can incorporate the correct nucleotide opposite a purine much more efficiently than opposite a pyrimidine, and prefers to insert guanosine instead of adenosine opposite thymidine. Pol iota is believed to use Hoogsteen rather than Watson-Crick base pairing, which may explain the varying efficiency for different template nucleotides.
Pssm-ID: 176457 [Multi-domain] Cd Length: 379 Bit Score: 63.64 E-value: 6.97e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800683915 9 DGNSFYCSCERVFDPKLAGVPV------IVLSNNdgcavartAEAKALGIRMGEPWFKIQALCKrEGVRAFSSNYTLYGD 82
Cdd:cd01703 4 DLDCFYAQVEEIRDPSLKSKPLgiqqkyIVVTCN--------YEARRLGVKKLMSIKDAKEICP-DLVLVNGEDLTPFRD 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800683915 83 MSARANAVYRDFAP--RVEIYSIDESFLDISDVREDRRRELAHDLRATVRAWTGIPTCVGIGPTKTLAKLANHIAKtiPE 160
Cdd:cd01703 75 MSKKVYRLLRSYSWndRVERLGFDENFMDVTEMRLLVASHIAYEMRERIENELGLTCCAGIASNKLLAKLVGSVNK--PN 152
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 1800683915 161 LRGV-CDLSDEDeRAAWLCRIHVGEVWGIGRASLAKLEAMGVDSVADLRDLDPRP 214
Cdd:cd01703 153 QQTTlLPPSCAD-LMDFMDLHDLRKIPGIGYKTAAKLEAHGISSVRDLQEFSNRN 206
|
|
| PTZ00205 |
PTZ00205 |
DNA polymerase kappa; Provisional |
8-326 |
1.25e-09 |
|
DNA polymerase kappa; Provisional
Pssm-ID: 140232 [Multi-domain] Cd Length: 571 Bit Score: 60.03 E-value: 1.25e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800683915 8 IDGNSFYCSCERVFDPKLAGVPVIVLSnndgCAVARTAE--AKALGIRMGEPWFKIQALCKreGVRAFSSNYTLYGDMSA 85
Cdd:PTZ00205 138 LDMDMFYAAVEIKKHPEYAAIPLAIGT----MTMLQTANyvARGRGIRQGMPGFLALKICP--NLLILPPDFDAYNEESN 211
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800683915 86 RANAVYRDFAPRVEIYSIDESFLDISDVRE-----DRRRELAHDLRATVRAWTGIPTCVGIGPTKTLAKLANHIAKtiPE 160
Cdd:PTZ00205 212 TVRRIVAEYDPNYISFGLDELTLEVSAYIErfegtKTAEDVASELRVRVFGETKLTASAGIGPTAALAKIASNINK--PN 289
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800683915 161 LRGVCDLSDEDERAAWLCRIHVGEVWGIGRASLAKLEAMGVDSVADLRDldpRPVrKAMTVVGERIIHELRGlACLPLEE 240
Cdd:PTZ00205 290 GQHDLNLHTRGDVMTYVRDLGLRSVPGVGKVTEALLKGLGITTLSDIYN---RRV-ELCYILHNNLFRFLLG-ASIGIMQ 364
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800683915 241 LP----------------AQRKGCAVTRSFsRRIEDRETMEQAVSAHATRLGEKLRRGGLGTTHVTVFYHTSEHdrgdpm 304
Cdd:PTZ00205 365 WPdaataantencegatgGQRKAISSERSF-TTPRTKEGLQEMVDTVFNGAYEEMRKSELMCRQISLTIRWASY------ 437
|
330 340
....*....|....*....|..
gi 1800683915 305 RSVSTTITLPEATNDTLALIRA 326
Cdd:PTZ00205 438 RYQQYTKSLIQYSDDSATLRRA 459
|
|
| PolY_Pol_eta |
cd01702 |
DNA Polymerase eta; Pol eta, also called Rad30A, is a translesion synthesis (TLS) polymerase. ... |
6-151 |
1.37e-08 |
|
DNA Polymerase eta; Pol eta, also called Rad30A, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Unlike other Y-family members, Pol eta can efficiently and accurately replicate DNA past UV-induced lesions. Its activity is initiated by two simultaneous interactions: the PIP box in pol eta interacting with PCNA, and the UBZ (ubiquitin-binding zinc finger) in pol eta interacting with monoubiquitin attached to PCNA. Pol eta is more efficient in copying damaged DNA than undamaged DNA and seems to recognize when a lesion has been passed, facilitating a lesion-dependent dissociation from the DNA.
Pssm-ID: 176456 [Multi-domain] Cd Length: 359 Bit Score: 56.17 E-value: 1.37e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800683915 6 ALIDGNSFYCSCERVFDPKLAGVPVIVLSNNDGCAVarTAEAKALGIRMGEPWFKIQALC------------KREGVRAF 73
Cdd:cd01702 1 AHIDMDAFFAQVEQVRLGLLRNDPVAVVQWNSIIAV--SYAARAFGVTRFMTIDEAKKKCpdlilahvatykKGEDEADY 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800683915 74 SSNY---------TLYGDMSARANAVYRDFAPRVEIYSIDESFLDISDvredrrrELAHDLRATVRAWTGIPTCVGIGPT 144
Cdd:cd01702 79 HENPsparhkvslDPYRRASRKILNILKRFGDVVEKASIDEAYLDLGS-------RIVEEIRQQVYDELGYTCSAGIAHN 151
|
....*..
gi 1800683915 145 KTLAKLA 151
Cdd:cd01702 152 KMLAKLA 158
|
|
| PolY_like |
cd03468 |
DNA Polymerase Y-family; Y-family DNA polymerases are a specialized subset of polymerases that ... |
29-325 |
2.67e-04 |
|
DNA Polymerase Y-family; Y-family DNA polymerases are a specialized subset of polymerases that facilitate translesion synthesis (TLS), a process that allows the bypass of a variety of DNA lesions. Unlike replicative polymerases, TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. The active sites of TLS polymerases are large and flexible to allow the accomodation of distorted bases. Expression of Y-family polymerases is often induced by DNA damage and is believed to be highly regulated. TLS is likely induced by the monoubiquitination of the replication clamp PCNA, which provides a scaffold for TLS polymerases to bind in order to access the lesion. Because of their high error rates, TLS polymerases are potential targets for cancer treatment and prevention.
Pssm-ID: 176458 [Multi-domain] Cd Length: 335 Bit Score: 42.75 E-value: 2.67e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800683915 29 PVIVLS-NNDGCAVARTAEAKALGIRMGEPWFKIQALCKREGVRAfssnYTLYGDMSA---RANAVYRdFAPRVEIYSID 104
Cdd:cd03468 24 PLAVVErKKAGRILACNAAARAAGVRPGMPLAEALALCPNLQVVE----YDPEADARAlqeLALWLLR-FTPLVALDGPD 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800683915 105 ESFLDISDVR--EDRRRELAHDLRATVRAwTGIPTCVGIGPTKTLAKLANHIAKTIPELRGVCDLSDEDERAAWLCRIHv 182
Cdd:cd03468 99 GLLLDVTGCLhlFGGEDALAASLRAALAT-LGLSARAGIADTPGAAWLLARAGGGRGVLRREALAAALVLLAPLPVAAL- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800683915 183 gevwGIGRASLAKLEAMGVDSVADLRDLDPRPVRK-----AMTVVGERIIHELRGLACLPLEELPAQRkgcaVTRSFsrR 257
Cdd:cd03468 177 ----RLPPETVELLARLGLRTLGDLAALPRAELARrfglaLLLRLDQAYGRDPEPLLFSPPPPAFDFR----LELQL--E 246
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1800683915 258 IEDRETMEQAVSAHATRLGEKLRRGGLGTTHVTVfyhTSEHDRGDPMRSVSTTITLPEATNDTLALIR 325
Cdd:cd03468 247 EPIARGLLFPLRRLLEQLCAFLALRGLGARRLSL---TLFREDGRVTRVLVGLARPSRDDLPLLRLLR 311
|
|
| IMS_HHH |
pfam11798 |
IMS family HHH motif; These proteins are involved in UV protection, eg. |
170-201 |
4.63e-03 |
|
IMS family HHH motif; These proteins are involved in UV protection, eg.
Pssm-ID: 432081 [Multi-domain] Cd Length: 32 Bit Score: 34.68 E-value: 4.63e-03
10 20 30
....*....|....*....|....*....|..
gi 1800683915 170 EDERAAWLCRIHVGEVWGIGRASLAKLEAMGV 201
Cdd:pfam11798 1 PDDVPEFLWPLPISKIPGIGKKLAEKLKALGI 32
|
|
| |
