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Conserved domains on  [gi|3947878|emb|CAA22289|]
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ER MAM associated 1-acylglycerol-3-phosphate acyltransferase Mlg1 [Schizosaccharomyces pombe]

Protein Classification

lysophospholipid acyltransferase family protein( domain architecture ID 10870651)

lysophospholipid acyltransferase (LPLAT) family protein may act as an acyltransferase of a de novo or remodeling pathway of glycerophospholipid biosynthesis, catalyzing the incorporation of an acyl group from either acyl-CoAs or acyl-acyl carrier proteins (acyl-ACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid

CATH:  1.10.1200.50
EC:  2.3.1.-
Gene Ontology:  GO:0016746|GO:0008654|GO:0006644
PubMed:  18287005|18931347|18718904|37611890
SCOP:  4003349

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LPLAT_LCLAT1-like cd07990
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; ...
 57-271 4.94e-63

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as Lysocardiolipin acyltransferase 1 (LCLAT1) or 1-acyl-sn-glycerol-3-phosphate acyltransferase and similar proteins.


:

Pssm-ID: 153252 [Multi-domain]  Cd Length: 193  Bit Score: 199.00  E-value: 4.94e-63
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3947878   57 TALVQLFSPTPVTLTYDPELrnlfyldrngcletIAAERNIVIANHQLYSDWMYVWWLSYTAKQHGHVYIMLKNSLKWLP 136
Cdd:cd07990   1 VFLFEWLSGVKVVVYGDEPK--------------LPKERALIISNHRSEVDWLVLWMLADRFGRLGRLKIVLKDSLKYPP 66

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3947878  137 VIGWGMQLFRFIFLSRKWDKDYETMSRHFKFIRNVRDSVSLILFPEGTNLVESTYQRSRVYADKIGVKMPKHLMLPRVRG 216
Cdd:cd07990  67 LGGWGWQLGEFIFLKRKWEKDEKTIKRQLKRLKDSPEPFWLLIFPEGTRFTEEKKERSQEFAEKNGLPPLKHVLLPRTKG 146

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*
gi 3947878  217 LFYSISQLRDSMTYLYDYTFYFSDPSPKKYAadafslpkLFFEGVPIKRLHIHVR 271
Cdd:cd07990 147 FVAILETLRDAVDAVYDVTIAYPDGKPPSEQ--------RLLLGGKPREVHVHVR 193
Acyltransf_C pfam16076
Acyltransferase C-terminus; This domain is found at the C-terminus of several different ...
 257-335 2.19e-16

Acyltransferase C-terminus; This domain is found at the C-terminus of several different acyltransferases including 1-acyl-sn-glycerol-3-phosphate acyltransferase, acyl-CoA:lysophosphatidylglycerol acyltransferase 1 and lysocardiolipin acyltransferase 1.


:

Pssm-ID: 465006 [Multi-domain]  Cd Length: 74  Bit Score: 72.99  E-value: 2.19e-16
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 3947878    257 FFEGVPIkRLHIHVRRFPISEIPTEEDQFTDWLYQRWYEKDKLIDTLLETGNFPGPKKLHTTVRLKhrleilSLFSVLF 335
Cdd:pfam16076   2 LLNGKPS-EVHMYIRRIPLEELPEDEEELAQWLHDLFVEKDKLLDYFYETGTFFPGKEHIIPRRLK------SLLVFIF 73
 
Name Accession Description Interval E-value
LPLAT_LCLAT1-like cd07990
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; ...
 57-271 4.94e-63

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as Lysocardiolipin acyltransferase 1 (LCLAT1) or 1-acyl-sn-glycerol-3-phosphate acyltransferase and similar proteins.


Pssm-ID: 153252 [Multi-domain]  Cd Length: 193  Bit Score: 199.00  E-value: 4.94e-63
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3947878   57 TALVQLFSPTPVTLTYDPELrnlfyldrngcletIAAERNIVIANHQLYSDWMYVWWLSYTAKQHGHVYIMLKNSLKWLP 136
Cdd:cd07990   1 VFLFEWLSGVKVVVYGDEPK--------------LPKERALIISNHRSEVDWLVLWMLADRFGRLGRLKIVLKDSLKYPP 66

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3947878  137 VIGWGMQLFRFIFLSRKWDKDYETMSRHFKFIRNVRDSVSLILFPEGTNLVESTYQRSRVYADKIGVKMPKHLMLPRVRG 216
Cdd:cd07990  67 LGGWGWQLGEFIFLKRKWEKDEKTIKRQLKRLKDSPEPFWLLIFPEGTRFTEEKKERSQEFAEKNGLPPLKHVLLPRTKG 146

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*
gi 3947878  217 LFYSISQLRDSMTYLYDYTFYFSDPSPKKYAadafslpkLFFEGVPIKRLHIHVR 271
Cdd:cd07990 147 FVAILETLRDAVDAVYDVTIAYPDGKPPSEQ--------RLLLGGKPREVHVHVR 193
PLN02510 PLN02510
probable 1-acyl-sn-glycerol-3-phosphate acyltransferase
 94-349 2.49e-49

probable 1-acyl-sn-glycerol-3-phosphate acyltransferase


Pssm-ID: 178126 [Multi-domain]  Cd Length: 374  Bit Score: 169.49  E-value: 2.49e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3947878    94 ERNIVIANHQLYSDWMYVWWLSYTAKQHGHVYIMLKNSLKWLPVIGWGMQLFRFIFLSRKWDKDYETMSRHFKFIRNVRD 173
Cdd:PLN02510  92 ERVLLIANHRTEVDWMYLWDLALRKGCLGYIKYVLKSSLMKLPVFGWAFHIFEFIPVERKWEVDEPNIRQMLSSFKDPRD 171

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3947878   174 SVSLILFPEGTNLVESTYQRSRVYADKIGVKMPKHLMLPRVRGLFYSISQLRDSMTYLYDYTFYFSDPSPkkyaadAFsL 253
Cdd:PLN02510 172 PLWLALFPEGTDYTEAKCQRSQKFAAEHGLPILNNVLLPKTKGFVSCLQELRCSLDAVYDVTIGYKHRCP------SF-L 244

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3947878   254 PKLFfeGVPIKRLHIHVRRFPISEIPTEEDQFTDWLYQRWYEKDKLIDTLLETGNFPG---PKKLHTTVRLKHRLEILSL 330
Cdd:PLN02510 245 DNVF--GIDPSEVHIHIRRIPLKQIPTSEDEVSAWLMDRFQLKDQLLSDFYAQGHFPNegtEGELSTLKCLANFLAVIAL 322

                        250       260
                 ....*....|....*....|
gi 3947878   331 FSVLFTC-IVAGLFLKLFIS 349
Cdd:PLN02510 323 TTVFTYLtLFSSVWFKIYVS 342
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
 97-214 1.30e-23

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 93.96  E-value: 1.30e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3947878      97 IVIANHQLYSDWMYVWWLSYtaKQHGHVYIMLKNSLKWLPVIGWGMQLFRFIFLSRKWDKDY-ETMSRHfkfIRNVRDSV 175
Cdd:smart00563   2 LVVANHQSFLDPLVLSALLP--RKLGRVRFVAKKELFYVPLLGWLLRLLGAIFIDRSNGRKArAALREA---VELLKEGE 76

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 3947878     176 SLILFPEGTNLVESTYQRSRVYADKIGVKmPKHLMLPRV 214
Cdd:smart00563  77 WLLIFPEGTRSRPGKLLPFKKGAARLALE-AGVPIVPVA 114
Acyltransf_C pfam16076
Acyltransferase C-terminus; This domain is found at the C-terminus of several different ...
 257-335 2.19e-16

Acyltransferase C-terminus; This domain is found at the C-terminus of several different acyltransferases including 1-acyl-sn-glycerol-3-phosphate acyltransferase, acyl-CoA:lysophosphatidylglycerol acyltransferase 1 and lysocardiolipin acyltransferase 1.


Pssm-ID: 465006 [Multi-domain]  Cd Length: 74  Bit Score: 72.99  E-value: 2.19e-16
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 3947878    257 FFEGVPIkRLHIHVRRFPISEIPTEEDQFTDWLYQRWYEKDKLIDTLLETGNFPGPKKLHTTVRLKhrleilSLFSVLF 335
Cdd:pfam16076   2 LLNGKPS-EVHMYIRRIPLEELPEDEEELAQWLHDLFVEKDKLLDYFYETGTFFPGKEHIIPRRLK------SLLVFIF 73
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
 88-185 6.66e-15

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 70.39  E-value: 6.66e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3947878     88 LETIAAERN-IVIANHQLYSDWMYVWWLSYtaKQHGHVYIMLKNSLKWLPVIGWGMQLFRFIFLSRKWDKDY-ETMSrhf 165
Cdd:pfam01553   7 LENLPRGGPaIVVANHQSYLDVLLLSLALY--KRGRPLVFVAKKELFDIPLVGWLMRLLGCIFIDRKNRKDAaGTLE--- 81

                          90       100
                  ....*....|....*....|
gi 3947878    166 KFIRNVRDSVSLILFPEGTN 185
Cdd:pfam01553  82 YLVELLREGKLVVIFPEGTR 101
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 88-184 1.56e-10

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 60.02  E-value: 1.56e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3947878   88 LETIAAERN-IVIANHQLYSDWMYVWWLSytakqHGHVYIMLKNSLKWLPVIGWGMQLFRFIFLSR-KWDKDYETMSRhf 165
Cdd:COG0204  36 LENLPADGPvLIVANHQSWLDILLLLAAL-----PRPVRFVAKKELFKIPLLGWLLRALGAIPVDRsKRRAALRALRQ-- 108

                        90
                ....*....|....*....
gi 3947878  166 kFIRNVRDSVSLILFPEGT 184
Cdd:COG0204 109 -AVEALKAGESLVIFPEGT 126
AGP_acyltrn TIGR00530
1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous ...
 97-184 3.27e-08

1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous region of a collection of related proteins, several of which are known to act as 1-acyl-sn-glycerol-3-phosphate acyltransferases (EC 2.3.1.51). Proteins scoring above the trusted cutoff are likely to have the same general activity. However, there is variation among characterized members as to whether the acyl group can be donated by acyl carrier protein or coenzyme A, and in the length and saturation of the donated acyl group. 1-acyl-sn-glycerol-3-phosphate acyltransferase is also called 1-AGP acyltransferase, lysophosphatidic acid acyltransferase, and LPA acyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 129621 [Multi-domain]  Cd Length: 130  Bit Score: 51.58  E-value: 3.27e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3947878     97 IVIANHQlysDWMYVWWLSYTAKQHGHvyIMLKNSLKWLPVIGWGMQLFRFIFLSRKWDKDYETMSRhfKFIRNVRDSVS 176
Cdd:TIGR00530  19 LVVANHQ---SNLDPLTLSAAFPPPIV--FIAKKELKWIPFFGIMLWLTGAIFIDRENIRAIATALK--AAIEVLKQGRS 91


                  ....*...
gi 3947878    177 LILFPEGT 184
Cdd:TIGR00530  92 IGVFPEGT 99
 
Name Accession Description Interval E-value
LPLAT_LCLAT1-like cd07990
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; ...
 57-271 4.94e-63

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as Lysocardiolipin acyltransferase 1 (LCLAT1) or 1-acyl-sn-glycerol-3-phosphate acyltransferase and similar proteins.


Pssm-ID: 153252 [Multi-domain]  Cd Length: 193  Bit Score: 199.00  E-value: 4.94e-63
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3947878   57 TALVQLFSPTPVTLTYDPELrnlfyldrngcletIAAERNIVIANHQLYSDWMYVWWLSYTAKQHGHVYIMLKNSLKWLP 136
Cdd:cd07990   1 VFLFEWLSGVKVVVYGDEPK--------------LPKERALIISNHRSEVDWLVLWMLADRFGRLGRLKIVLKDSLKYPP 66

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3947878  137 VIGWGMQLFRFIFLSRKWDKDYETMSRHFKFIRNVRDSVSLILFPEGTNLVESTYQRSRVYADKIGVKMPKHLMLPRVRG 216
Cdd:cd07990  67 LGGWGWQLGEFIFLKRKWEKDEKTIKRQLKRLKDSPEPFWLLIFPEGTRFTEEKKERSQEFAEKNGLPPLKHVLLPRTKG 146

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*
gi 3947878  217 LFYSISQLRDSMTYLYDYTFYFSDPSPKKYAadafslpkLFFEGVPIKRLHIHVR 271
Cdd:cd07990 147 FVAILETLRDAVDAVYDVTIAYPDGKPPSEQ--------RLLLGGKPREVHVHVR 193
PLN02510 PLN02510
probable 1-acyl-sn-glycerol-3-phosphate acyltransferase
 94-349 2.49e-49

probable 1-acyl-sn-glycerol-3-phosphate acyltransferase


Pssm-ID: 178126 [Multi-domain]  Cd Length: 374  Bit Score: 169.49  E-value: 2.49e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3947878    94 ERNIVIANHQLYSDWMYVWWLSYTAKQHGHVYIMLKNSLKWLPVIGWGMQLFRFIFLSRKWDKDYETMSRHFKFIRNVRD 173
Cdd:PLN02510  92 ERVLLIANHRTEVDWMYLWDLALRKGCLGYIKYVLKSSLMKLPVFGWAFHIFEFIPVERKWEVDEPNIRQMLSSFKDPRD 171

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3947878   174 SVSLILFPEGTNLVESTYQRSRVYADKIGVKMPKHLMLPRVRGLFYSISQLRDSMTYLYDYTFYFSDPSPkkyaadAFsL 253
Cdd:PLN02510 172 PLWLALFPEGTDYTEAKCQRSQKFAAEHGLPILNNVLLPKTKGFVSCLQELRCSLDAVYDVTIGYKHRCP------SF-L 244

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3947878   254 PKLFfeGVPIKRLHIHVRRFPISEIPTEEDQFTDWLYQRWYEKDKLIDTLLETGNFPG---PKKLHTTVRLKHRLEILSL 330
Cdd:PLN02510 245 DNVF--GIDPSEVHIHIRRIPLKQIPTSEDEVSAWLMDRFQLKDQLLSDFYAQGHFPNegtEGELSTLKCLANFLAVIAL 322

                        250       260
                 ....*....|....*....|
gi 3947878   331 FSVLFTC-IVAGLFLKLFIS 349
Cdd:PLN02510 323 TTVFTYLtLFSSVWFKIYVS 342
PLN02380 PLN02380
1-acyl-sn-glycerol-3-phosphate acyltransferase
 42-345 1.12e-31

1-acyl-sn-glycerol-3-phosphate acyltransferase


Pssm-ID: 178006 [Multi-domain]  Cd Length: 376  Bit Score: 122.54  E-value: 1.12e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3947878    42 NKYIAFTKSFAGILFTALVQLF---SPTPVTLTYDPELRNLFyldrngcletiAAERNIVIANHQLYSDWMYVWWLSYTA 118
Cdd:PLN02380  40 SLYRRINRAVAELLWLELIWLVdwwAGVKVQLYADEETFELM-----------GKEHALVISNHRSDIDWLVGWILAQRS 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3947878   119 KQHGHVYIMLKNSLKWLPVIGWGMQLFRFIFLSRKWDKDYETMSRHFKFIRNVRDSVSLILFPEGTNLVESTYQRSRVYA 198
Cdd:PLN02380 109 GCLGSALAVMKKSSKFLPVIGWSMWFSEYVFLERSWAKDENTLKSGFQRLKDFPRPFWLALFVEGTRFTQAKLLAAQEYA 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3947878   199 DKIGVKMPKHLMLPRVRGLFYSISQLRDSMTYLYDYTFYFSDPSPKkyaadafslPKL--FFEGVPiKRLHIHVRRFPIS 276
Cdd:PLN02380 189 ASRGLPVPRNVLIPRTKGFVSAVSNMRSFVPAIYDVTVAVPKGQPA---------PTMlrIFRGQS-SVVHVHIKRHSMK 258

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 3947878   277 EIPTEEDQFTDWLYQRWYEKDKLIDTLLETGNFPGpKKLHTTVRLKHRLEILSLFSVLFtCIVAGLFLK 345
Cdd:PLN02380 259 ELPETDDGIAQWCKDVFVAKDALLDKHFAEDTFGD-QEYQDIGRPKKSLIVVISWACLL-ILGAIKFLQ 325
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
 97-214 1.30e-23

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 93.96  E-value: 1.30e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3947878      97 IVIANHQLYSDWMYVWWLSYtaKQHGHVYIMLKNSLKWLPVIGWGMQLFRFIFLSRKWDKDY-ETMSRHfkfIRNVRDSV 175
Cdd:smart00563   2 LVVANHQSFLDPLVLSALLP--RKLGRVRFVAKKELFYVPLLGWLLRLLGAIFIDRSNGRKArAALREA---VELLKEGE 76

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 3947878     176 SLILFPEGTNLVESTYQRSRVYADKIGVKmPKHLMLPRV 214
Cdd:smart00563  77 WLLIFPEGTRSRPGKLLPFKKGAARLALE-AGVPIVPVA 114
Acyltransf_C pfam16076
Acyltransferase C-terminus; This domain is found at the C-terminus of several different ...
 257-335 2.19e-16

Acyltransferase C-terminus; This domain is found at the C-terminus of several different acyltransferases including 1-acyl-sn-glycerol-3-phosphate acyltransferase, acyl-CoA:lysophosphatidylglycerol acyltransferase 1 and lysocardiolipin acyltransferase 1.


Pssm-ID: 465006 [Multi-domain]  Cd Length: 74  Bit Score: 72.99  E-value: 2.19e-16
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 3947878    257 FFEGVPIkRLHIHVRRFPISEIPTEEDQFTDWLYQRWYEKDKLIDTLLETGNFPGPKKLHTTVRLKhrleilSLFSVLF 335
Cdd:pfam16076   2 LLNGKPS-EVHMYIRRIPLEELPEDEEELAQWLHDLFVEKDKLLDYFYETGTFFPGKEHIIPRRLK------SLLVFIF 73
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
 88-185 6.66e-15

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 70.39  E-value: 6.66e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3947878     88 LETIAAERN-IVIANHQLYSDWMYVWWLSYtaKQHGHVYIMLKNSLKWLPVIGWGMQLFRFIFLSRKWDKDY-ETMSrhf 165
Cdd:pfam01553   7 LENLPRGGPaIVVANHQSYLDVLLLSLALY--KRGRPLVFVAKKELFDIPLVGWLMRLLGCIFIDRKNRKDAaGTLE--- 81

                          90       100
                  ....*....|....*....|
gi 3947878    166 KFIRNVRDSVSLILFPEGTN 185
Cdd:pfam01553  82 YLVELLREGKLVVIFPEGTR 101
LPLAT_AGPAT-like cd07989
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; ...
 97-184 6.44e-11

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.


Pssm-ID: 153251 [Multi-domain]  Cd Length: 184  Bit Score: 60.75  E-value: 6.44e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3947878   97 IVIANHQLYSDWMYVWWLSytakqHGHVYIMLKNSLKWLPVIGWGMQLFRFIFLSR-KWDKDYETMSRhfkFIRNVRDSV 175
Cdd:cd07989  27 IIVANHQSYLDPLVLGAAL-----PRPIRFVAKKELFKIPFLGWLLRLLGAIPIDRgNGRSAREALRE---AIEALKEGE 98


                ....*....
gi 3947878  176 SLILFPEGT 184
Cdd:cd07989  99 SVVIFPEGT 107
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 88-184 1.56e-10

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 60.02  E-value: 1.56e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3947878   88 LETIAAERN-IVIANHQLYSDWMYVWWLSytakqHGHVYIMLKNSLKWLPVIGWGMQLFRFIFLSR-KWDKDYETMSRhf 165
Cdd:COG0204  36 LENLPADGPvLIVANHQSWLDILLLLAAL-----PRPVRFVAKKELFKIPLLGWLLRALGAIPVDRsKRRAALRALRQ-- 108

                        90
                ....*....|....*....
gi 3947878  166 kFIRNVRDSVSLILFPEGT 184
Cdd:COG0204 109 -AVEALKAGESLVIFPEGT 126
PRK14014 PRK14014
putative acyltransferase; Provisional
 98-308 1.59e-09

putative acyltransferase; Provisional


Pssm-ID: 237584 [Multi-domain]  Cd Length: 301  Bit Score: 58.32  E-value: 1.59e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3947878    98 VIANHQLYSDwMYVwwLSYTAKQHghvyI-----MLKNSLKWLPVIG---WGMQlfrFIFLSR-----------KWDKDY 158
Cdd:PRK14014  91 VISNHQSWVD-ILV--LQYVFNRR----IpmlkfFLKQELIWVPFLGlawWALD---FPFMKRyskaylaknpeLKGKDL 160

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3947878   159 ETMSR---HFKFIrnvrdSVSLILFPEGTNLVESTYQRSRV-YadkigvkmpKHLMLPRVRGLFYSISQLRDSMTYLYDY 234
Cdd:PRK14014 161 ETTRRaceKFKRM-----PTTIVNFVEGTRFTPEKHQQQQSpY---------QHLLKPKAGGIAFALNAMGEQFDGLLDV 226

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3947878   235 TFYFSDPSPKKYAadafslpklFFEGvPIKRLHIHVRRFPISEIPT---EED-----QFTDWLYQRWYEKDKLIDTLLET 306
Cdd:PRK14014 227 TIVYPDGRPSFWD---------LLSG-RVKKIVVHVRLLPIPEELIgdyFNDkefrrRFQQWLNQLWQEKDQLIEQLLAQ 296


                 ..
gi 3947878   307 GN 308
Cdd:PRK14014 297 YN 298
AGP_acyltrn TIGR00530
1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous ...
 97-184 3.27e-08

1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous region of a collection of related proteins, several of which are known to act as 1-acyl-sn-glycerol-3-phosphate acyltransferases (EC 2.3.1.51). Proteins scoring above the trusted cutoff are likely to have the same general activity. However, there is variation among characterized members as to whether the acyl group can be donated by acyl carrier protein or coenzyme A, and in the length and saturation of the donated acyl group. 1-acyl-sn-glycerol-3-phosphate acyltransferase is also called 1-AGP acyltransferase, lysophosphatidic acid acyltransferase, and LPA acyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 129621 [Multi-domain]  Cd Length: 130  Bit Score: 51.58  E-value: 3.27e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3947878     97 IVIANHQlysDWMYVWWLSYTAKQHGHvyIMLKNSLKWLPVIGWGMQLFRFIFLSRKWDKDYETMSRhfKFIRNVRDSVS 176
Cdd:TIGR00530  19 LVVANHQ---SNLDPLTLSAAFPPPIV--FIAKKELKWIPFFGIMLWLTGAIFIDRENIRAIATALK--AAIEVLKQGRS 91


                  ....*...
gi 3947878    177 LILFPEGT 184
Cdd:TIGR00530  92 IGVFPEGT 99
LPLAT cd06551
Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; ...
 97-184 4.24e-06

Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Lysophospholipid acyltransferase (LPLAT) superfamily members are acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis. These proteins catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this superfamily are LPLATs such as glycerol-3-phosphate 1-acyltransferase (GPAT, PlsB), 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), lysophosphatidylcholine acyltransferase 1 (LPCAT-1), lysophosphatidylethanolamine acyltransferase (LPEAT, also known as, MBOAT2, membrane-bound O-acyltransferase domain-containing protein 2), lipid A biosynthesis lauroyl/myristoyl acyltransferase, 2-acylglycerol O-acyltransferase (MGAT), dihydroxyacetone phosphate acyltransferase (DHAPAT, also known as 1 glycerol-3-phosphate O-acyltransferase 1) and Tafazzin (the protein product of the Barth syndrome (TAZ) gene).


Pssm-ID: 153244 [Multi-domain]  Cd Length: 187  Bit Score: 46.64  E-value: 4.24e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3947878   97 IVIANHQLYSDWMYVWWLSYTAKQHGHVYIMLKNSLKWLPVIGWGmqlfRFIFLSRKWD----KDYETMSRHFKFIRNVr 172
Cdd:cd06551  29 LFVSNHSSWWDGLILFLLLERGLRRDVYGLMDEELLERYPFFTRL----GAFSVDRDSPrsaaKSLKYVARLLSKPGSV- 103

                        90
                ....*....|..
gi 3947878  173 dsvsLILFPEGT 184
Cdd:cd06551 104 ----VWIFPEGT 111
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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