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Conserved domains on  [gi|296674|emb|CAA30171|]
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T-cell receptor V-beta 8.1, partial [Homo sapiens]

Protein Classification

immunoglobulin domain-containing family protein( domain architecture ID 34076)

immunoglobulin (Ig) domain-containing family protein is a member of a large superfamily containing cell surface antigen receptors, co-receptors and co-stimulatory molecules of the immune system, molecules involved in antigen presentation to lymphocytes, cell adhesion molecules, certain cytokine receptors and intracellular muscle proteins; immunoglobulin domains are typically divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ig super family cl11960
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 23-116 1.97e-41

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


The actual alignment was detected with superfamily member cd05899:

Pssm-ID: 472250  Cd Length: 110  Bit Score: 132.41  E-value: 1.97e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296674    23 VIQSPRHEVTEMGQEVTLRCKPISGHNSLFWYRQTMMRGLELLIYFNNNVPIDDSGMPEDRFSAKMPNASFSTLKIQPSE 102
Cdd:cd05899   1 VTQSPRYLIKRRGQSVTLRCSQKSGHDNMYWYRQDPGKGLQLLFYSYGGGLNEEGDLPGDRFSASRPSLTRSSLTIKSAE 80

                        90
                ....*....|....
gi 296674   103 PRDSAVYFCASSLA 116
Cdd:cd05899  81 PEDSAVYLCASSLG 94
 
Name Accession Description Interval E-value
IgV_TCR_beta cd05899
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) beta chain; The members here ...
 23-116 1.97e-41

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) beta chain; The members here are composed of the immunoglobulin (Ig) variable domain of the beta chain of alpha/beta T-cell antigen receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are composed of alpha and beta, or gamma and delta, polypeptide chains with variable (V) and constant (C) regions. This group includes the variable domain of the alpha chain of alpha/beta TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. The variable domain of TCRs is responsible for antigen recognition, and is located at the N-terminus of the receptor. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409480  Cd Length: 110  Bit Score: 132.41  E-value: 1.97e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296674    23 VIQSPRHEVTEMGQEVTLRCKPISGHNSLFWYRQTMMRGLELLIYFNNNVPIDDSGMPEDRFSAKMPNASFSTLKIQPSE 102
Cdd:cd05899   1 VTQSPRYLIKRRGQSVTLRCSQKSGHDNMYWYRQDPGKGLQLLFYSYGGGLNEEGDLPGDRFSASRPSLTRSSLTIKSAE 80

                        90
                ....*....|....
gi 296674   103 PRDSAVYFCASSLA 116
Cdd:cd05899  81 PEDSAVYLCASSLG 94
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 25-112 3.38e-10

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 52.85  E-value: 3.38e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296674      25 QSPRhEVTEM-GQEVTLRCK----PISGHNSLFWYRQTMMRGLELLIYFNNNvpIDDSGMPEDRFSAKM-PNASFSTLKI 98
Cdd:pfam07686   1 QTPR-EVTVAlGGSVTLPCTysssMSEASTSVYWYRQPPGKGPTFLIAYYSN--GSEEGVKKGRFSGRGdPSNGDGSLTI 77

                          90
                  ....*....|....
gi 296674      99 QPSEPRDSAVYFCA 112
Cdd:pfam07686  78 QNLTLSDSGTYTCA 91
IGv smart00406
Immunoglobulin V-Type;
38-112 2.18e-09

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 50.07  E-value: 2.18e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296674       38 VTLRCK---PISGHNSLFWYRQTMMRGLELLIYFNNNVPIDDSGMPEDRF--SAKMPNASFsTLKIQPSEPRDSAVYFCA 112
Cdd:smart00406   2 VTLSCKfsgSTFSSYYVSWVRQPPGKGLEWLGYIGSNGSSYYQESYKGRFtiSKDTSKNDV-SLTISNLRVEDTGTYYCA 80
 
Name Accession Description Interval E-value
IgV_TCR_beta cd05899
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) beta chain; The members here ...
 23-116 1.97e-41

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) beta chain; The members here are composed of the immunoglobulin (Ig) variable domain of the beta chain of alpha/beta T-cell antigen receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are composed of alpha and beta, or gamma and delta, polypeptide chains with variable (V) and constant (C) regions. This group includes the variable domain of the alpha chain of alpha/beta TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. The variable domain of TCRs is responsible for antigen recognition, and is located at the N-terminus of the receptor. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409480  Cd Length: 110  Bit Score: 132.41  E-value: 1.97e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296674    23 VIQSPRHEVTEMGQEVTLRCKPISGHNSLFWYRQTMMRGLELLIYFNNNVPIDDSGMPEDRFSAKMPNASFSTLKIQPSE 102
Cdd:cd05899   1 VTQSPRYLIKRRGQSVTLRCSQKSGHDNMYWYRQDPGKGLQLLFYSYGGGLNEEGDLPGDRFSASRPSLTRSSLTIKSAE 80

                        90
                ....*....|....
gi 296674   103 PRDSAVYFCASSLA 116
Cdd:cd05899  81 PEDSAVYLCASSLG 94
IgV cd00099
Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin ...
 23-114 2.48e-27

Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin variable domain (IgV). The IgV family contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology, and are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E and, D strands in one sheet and A', G, F, C, C', and C" strands in the other.


Pssm-ID: 409355 [Multi-domain]  Cd Length: 111  Bit Score: 96.63  E-value: 2.48e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296674    23 VIQSPRHEVTEMGQEVTLRCKPIS--GHNSLFWYRQTMMRGLELLIYFNNNVPIDdSGMPEDRFSAKMPNASFSTLKIQP 100
Cdd:cd00099   1 VTQSPRSLSVQEGESVTLSCEVSSsfSSTYIYWYRQKPGQGPEFLIYLSSSKGKT-KGGVPGRFSGSRDGTSSFSLTISN 79

                        90
                ....*....|....
gi 296674   101 SEPRDSAVYFCASS 114
Cdd:cd00099  80 LQPEDSGTYYCAVS 93
IgV_TCR_alpha cd04983
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) alpha chain and similar ...
 23-112 2.19e-19

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) alpha chain and similar proteins; The members here are composed of the immunoglobulin (Ig) variable domain of the alpha chain of alpha/beta T-cell antigen receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are composed of alpha and beta, or gamma and delta polypeptide chains with variable (V) and constant (C) regions. This group represents the variable domain of the alpha chain of TCRs and also includes the variable domain of delta chains of TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. The variable domain of TCRs is responsible for antigen recognition, and is located at the N-terminus of the receptor. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409372 [Multi-domain]  Cd Length: 109  Bit Score: 76.54  E-value: 2.19e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296674    23 VIQSPRH-EVTEmGQEVTLRCK-PISGHNSLFWYRQTMMRGLELLIYfnnnvpIDDSGMPE--DRFSA--KMPNASFStL 96
Cdd:cd04983   1 VTQSPQSlSVQE-GENVTLNCNySTSTFYYLFWYRQYPGQGPQFLIY------ISSDSGNKkkGRFSAtlDKSRKSSS-L 72

                        90
                ....*....|....*.
gi 296674    97 KIQPSEPRDSAVYFCA 112
Cdd:cd04983  73 HISAAQLSDSAVYFCA 88
IgV_TCR_gamma cd04982
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) gamma chain; The members here ...
 25-113 1.55e-13

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) gamma chain; The members here are composed of the immunoglobulin (Ig) variable (V) domain of the gamma chain of gamma/delta T-cell receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are heterodimers consisting of alpha and beta chains or gamma and delta chains. Each chain contains a variable (V) and a constant (C) region. The majority of T cells contain alpha/beta TCRs, but a small subset contain gamma/delta TCRs. Alpha/beta TCRs recognize antigens as peptide fragments presented by major histocompatibility complex (MHC) molecules. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Gamma/delta T cells can also be stimulated by non-peptide antigens such as small phosphate- or amine-containing compounds. The variable domain of gamma/delta TCRs is responsible for antigen recognition and is located at the N-terminus of the receptor. Members of this group contain the standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409371  Cd Length: 117  Bit Score: 61.61  E-value: 1.55e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296674    25 QSPRHEVTEMGQEVTLRCKpISG---HNS-LFWYRQTMMRGLELLIYFNNNVP-IDDSGMPEDRFSA-KMPNASFSTLKI 98
Cdd:cd04982   3 QPQLSITREESKSVTISCK-VSGidfSTTyIHWYRQKPGQALERLLYVSSTSAvRKDSGKTKNKFEArKDVGKSTSTLTI 81

                        90
                ....*....|....*
gi 296674    99 QPSEPRDSAVYFCAS 113
Cdd:cd04982  82 TNLEKEDSATYYCAY 96
IgV_L_kappa cd04980
Immunoglobulin (Ig) light chain, kappa type, variable (V) domain; The members here are ...
 23-111 7.84e-13

Immunoglobulin (Ig) light chain, kappa type, variable (V) domain; The members here are composed of the immunoglobulin (Ig) light chain, kappa type, variable (V) domain. This group contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. There are two types of light chains: kappa and lambda, each composed of a constant domain (CL) and a variable domain (VL). There are five types of heavy chains (alpha, gamma, delta, epsilon, and mu), which determines the type of immunoglobulin formed: IgA, IgG, IgD, IgE, and IgM, respectively. In higher vertebrates, there are two types of light chain, designated kappa and lambda, which seem to be functionally identical, and can associate with any of the heavy chains.


Pssm-ID: 409369  Cd Length: 106  Bit Score: 59.71  E-value: 7.84e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296674    23 VIQSPRHEVTEMGQEVTLRCKP--ISGHNSLFWYRQTMMRGLELLIYFNNNVpidDSGMPeDRFSAKMPNASFsTLKIQP 100
Cdd:cd04980   3 MTQSPASLSVSPGERVTISCKAsqSISSNYLAWYQQKPGQAPKLLIYYASTL---HSGVP-SRFSGSGSGTDF-TLTISS 77

                        90
                ....*....|.
gi 296674   101 SEPRDSAVYFC 111
Cdd:cd04980  78 VEPEDAAVYYC 88
IgV_L_lambda cd04984
Immunoglobulin (Ig) lambda light chain variable (V) domain; The members here are composed of ...
 23-114 1.34e-10

Immunoglobulin (Ig) lambda light chain variable (V) domain; The members here are composed of the immunoglobulin (Ig) light chain, lambda type, variable (V) domain. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. There are two types of light chains: kappa and lambda, each composed of a constant domain (CL) and a variable domain (VL). There are five types of heavy chains (alpha, gamma, delta, epsilon, and mu), which determines the type of immunoglobulin formed: IgA, IgG, IgD, IgE, and IgM, respectively. In higher vertebrates, there are two types of light chain, designated kappa and lambda, which seem to be functionally identical, and can associate with any of the heavy chains. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409373  Cd Length: 105  Bit Score: 54.00  E-value: 1.34e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296674    23 VIQSPRHEVTEMGQEVTLRCKPISGH---NSLFWYRQTMMRGLELLIYFNNNVPiddSGMPeDRFSAKMPNASfSTLKIQ 99
Cdd:cd04984   1 VLTQPSSLSVSPGETVTITCTGSSGNisgNYVNWYQQKPGSAPRYLIYEDKHRP---SGIP-DRFSGSKSGNT-ASLTIS 75

                        90
                ....*....|....*
gi 296674   100 PSEPRDSAVYFCASS 114
Cdd:cd04984  76 GAQTEDEADYYCQVW 90
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 25-112 3.38e-10

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 52.85  E-value: 3.38e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296674      25 QSPRhEVTEM-GQEVTLRCK----PISGHNSLFWYRQTMMRGLELLIYFNNNvpIDDSGMPEDRFSAKM-PNASFSTLKI 98
Cdd:pfam07686   1 QTPR-EVTVAlGGSVTLPCTysssMSEASTSVYWYRQPPGKGPTFLIAYYSN--GSEEGVKKGRFSGRGdPSNGDGSLTI 77

                          90
                  ....*....|....
gi 296674      99 QPSEPRDSAVYFCA 112
Cdd:pfam07686  78 QNLTLSDSGTYTCA 91
IGv smart00406
Immunoglobulin V-Type;
38-112 2.18e-09

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 50.07  E-value: 2.18e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296674       38 VTLRCK---PISGHNSLFWYRQTMMRGLELLIYFNNNVPIDDSGMPEDRF--SAKMPNASFsTLKIQPSEPRDSAVYFCA 112
Cdd:smart00406   2 VTLSCKfsgSTFSSYYVSWVRQPPGKGLEWLGYIGSNGSSYYQESYKGRFtiSKDTSKNDV-SLTISNLRVEDTGTYYCA 80
IgV_TCR_delta cd07706
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) delta chain; The members here ...
 23-115 9.04e-09

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) delta chain; The members here are composed of the immunoglobulin (Ig) variable (V) domain of the delta chain of gamma/delta T-cell receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are heterodimers consisting of alpha and beta chains or gamma and delta chains. Each chain contains a variable (V) and a constant (C) region. The majority of T cells contain alpha/beta TCRs, but a small subset contain gamma/delta TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. Gamma/delta TCRs recognize intact protein antigens; they recognize protein antigens directly and without antigen processing, and MHC independently of the bound peptide. Gamma/delta T cells can also be stimulated by non-peptide antigens such as small phosphate- or amine-containing compounds. The variable domain of gamma/delta TCRs is responsible for antigen recognition and is located at the N-terminus of the receptor. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409503  Cd Length: 112  Bit Score: 49.44  E-value: 9.04e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296674    23 VIQSPRHEVTEMGQEVTLRCKPISGHNS--LFWYRQTMMRGLELLIYFNNNVPIDDSGmpedRFSAKMPNA--SFStLKI 98
Cdd:cd07706   2 VTQAQPDVSVQVGEEVTLNCRYETSWTNyyLFWYKQLPSGEMTFLIRQDSSEQNAKSG----RYSVNFQKAqkSIS-LTI 76

                        90
                ....*....|....*..
gi 296674    99 QPSEPRDSAVYFCASSL 115
Cdd:cd07706  77 SALQLEDSAKYFCALSL 93
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 27-114 2.04e-08

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 47.89  E-value: 2.04e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296674       27 PRHEVTEMGQEVTLRCKPIS-GHNSLFWYRQtmmrGLELLIYfnnnvpiddsgmpEDRFSAKmPNASFSTLKIQPSEPRD 105
Cdd:smart00410   1 PPSVTVKEGESVTLSCEASGsPPPEVTWYKQ----GGKLLAE-------------SGRFSVS-RSGSTSTLTISNVTPED 62


                   ....*....
gi 296674      106 SAVYFCASS 114
Cdd:smart00410  63 SGTYTCAAT 71
IgV_H cd04981
Immunoglobulin (Ig) heavy chain (H), variable (V) domain; The members here are composed of the ...
 35-115 6.66e-06

Immunoglobulin (Ig) heavy chain (H), variable (V) domain; The members here are composed of the immunoglobulin (Ig) heavy chain (H), variable (V) domain. This group contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. There are five types of heavy chains (alpha, gamma, delta, epsilon, and mu), which determines the type of immunoglobulin formed: IgA, IgG, IgD, IgE, and IgM, respectively. In higher vertebrates, there are two types of light chain, designated kappa and lambda, which can associate with any of the heavy chains. This family includes alpha, gamma, delta, epsilon, and mu heavy chains.


Pssm-ID: 409370 [Multi-domain]  Cd Length: 118  Bit Score: 41.91  E-value: 6.66e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296674    35 GQEVTLRCKpISGH----NSLFWYRQTMMRGLELL-IYFNNNVPIDDSGMPEDRFSAKmPNASFST--LKIQPSEPRDSA 107
Cdd:cd04981  13 GQSLKLSCK-ASGFtftsYGMGWVRQAPGKGLEWIgLIYPGGGDTYYADSFKGRFTIT-RDTSKSTayLQLNSLTSEDTA 90


                ....*...
gi 296674   108 VYFCASSL 115
Cdd:cd04981  91 VYYCARGL 98
IgV_CD8_alpha cd05720
Immunoglobulin (Ig)-like variable (V) domain of Cluster of Differentiation (CD) 8 alpha chain; ...
 26-114 9.46e-05

Immunoglobulin (Ig)-like variable (V) domain of Cluster of Differentiation (CD) 8 alpha chain; The members here are composed of the immunoglobulin (Ig)-like variable domain of the Cluster of Differentiation (CD) 8 alpha. The CD8 glycoprotein plays an essential role in the control of T-cell selection, maturation, and the T-cell receptor (TCR)-mediated response to peptide antigen. CD8 is comprised of alpha and beta subunits and is expressed as either an alpha/alpha or alpha/beta dimer. Both dimeric isoforms can serve as a coreceptor for T cell activation and differentiation, however they have distinct physiological roles, different cellular distributions, unique binding partners, etc. Each CD8 subunit is comprised of an extracellular domain containing a V-type Ig-like domain, a single pass transmembrane portion, and a short intracellular domain. The Ig domain of CD8 alpha binds to antibodies. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409385  Cd Length: 110  Bit Score: 38.62  E-value: 9.46e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296674    26 SPRHEVTEMGQEVTLRCKPI-SGHNSLFWYRQT--MMRGLELLIYFN-NNVPIDDSGMPEDRFSAKMPNASFsTLKIQPS 101
Cdd:cd05720   4 SPRKRDAQLGQKVELVCEVLnSVPQGCSWLFQPrgSAPQPTFLLYLSsSNKTKWAEGLDSKRFSGSRSGSSY-VLTLKDF 82

                        90
                ....*....|...
gi 296674   102 EPRDSAVYFCASS 114
Cdd:cd05720  83 RKEDEGYYFCSVI 95
IgV_CD8_beta cd07700
Immunoglobulin (Ig) variable (V) domain of Cluster of Differentiation (CD) 8 beta chain; The ...
 24-112 1.92e-04

Immunoglobulin (Ig) variable (V) domain of Cluster of Differentiation (CD) 8 beta chain; The members here are composed of the immunoglobulin (Ig)-like domain in Cluster of Differentiation (CD) 8 beta. The CD8 glycoprotein plays an essential role in the control of T-cell selection, maturation, and the T-cell receptor (TCR)-mediated response to peptide antigen. CD8 is comprised of alpha and beta subunits and is expressed as either an alpha/alpha or alpha/beta dimer. Both dimeric isoforms can serve as a coreceptor for T cell activation and differentiation, however they have distinct physiological roles, different cellular distributions, unique binding partners, etc. Each CD8 subunit is comprised of an extracellular domain containing a V-type Ig-like domain, a single pass transmembrane portion, and a short intracellular domain. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409497  Cd Length: 116  Bit Score: 37.81  E-value: 1.92e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296674    24 IQSPRHEVTEMGQEVTLRC--KPISGHNSLFWYRQ----TMMRGLELLIYFN-NNVPIDDSGMPEDRFSAKMPNASFS-T 95
Cdd:cd07700   2 LQTPGSLLVQTNQTVKMSCeaKTSPKNTRIYWLRQrqapSKDSHFEFLASWDpSKGIVYGEGVDQEKLIILSDSDSSRyI 81

                        90
                ....*....|....*..
gi 296674    96 LKIQPSEPRDSAVYFCA 112
Cdd:cd07700  82 LSLMSVKPEDSGTYFCM 98
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 23-111 6.41e-04

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 36.00  E-value: 6.41e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296674      23 VIQSPRHEVTEMGQEVTLRCKPISG-HNSLFWYRqtmmrglelliyfnnnvpiDDSGMPEDRFSAKMPNASFSTLKIQPS 101
Cdd:pfam13927   4 ITVSPSSVTVREGETVTLTCEATGSpPPTITWYK-------------------NGEPISSGSTRSRSLSGSNSTLTISNV 64

                          90
                  ....*....|
gi 296674     102 EPRDSAVYFC 111
Cdd:pfam13927  65 TRSDAGTYTC 74
IgV_TCR_gammadelta cd20988
Gammadelta T-cell antigen receptor, variable (V) domain; The members here are composed of the ...
 27-113 6.72e-03

Gammadelta T-cell antigen receptor, variable (V) domain; The members here are composed of the immunoglobulin (Ig) variable (V) domain of the gamma/delta T-cell receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are heterodimers consisting of alpha and beta chains or gamma and delta chains. Each chain contains a variable (V) and a constant (C) region. The majority of T cells contain alpha/beta TCRs, but a small subset contain gamma/delta TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. Gamma/delta TCRs recognize intact protein antigens; they recognize protein antigens directly and without antigen processing, and MHC independently of the bound peptide. Gamma/delta T cells can also be stimulated by non-peptide antigens such as small phosphate- or amine-containing compounds. The variable domain of gamma/delta TCRs is responsible for antigen recognition and is located at the N-terminus of the receptor. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409580  Cd Length: 114  Bit Score: 33.68  E-value: 6.72e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296674    27 PRHEV--TEMGQEVTLRCKPISGHNS---LFWYRQTMMRGLELlIYFNNNvpIDDSGMpEDRFSAKMPNA-SFSTLKIQP 100
Cdd:cd20988   3 PEHQTvtVSVGKPVTLKCSMKGEAISnyyINWYRKTQGNTMTF-IYREGG--IYGPGF-KDNFRGDIDSSnNLAVLKILE 78

                        90
                ....*....|...
gi 296674   101 SEPRDSAVYFCAS 113
Cdd:cd20988  79 ASERDEGSYYCAS 91
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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