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Conserved domains on  [gi|1793149924|emb|CAA4475750|]
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IgG-binding protein SBI [Staphylococcus aureus]

Protein Classification

immunoglobulin G-binding protein A( domain architecture ID 10491246)

immunoglobulin G-binding protein A is a cell-wall-bound pathogenicity factor that avidly binds the Fc region of immunoglobulins from most mammalian species in a non-specific aggregation reaction that can lead to host tissue damage

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Sbi-IV pfam11621
C3 binding domain 4 of IgG-bind protein SBI; This family of proteins represents Sbi domain IV ...
198-266 1.00e-33

C3 binding domain 4 of IgG-bind protein SBI; This family of proteins represents Sbi domain IV which binds the central complement protein C3. Sbi-IV interacts with Sbi-III to induce a consumption of complement via alternative pathway activation. When not interacting with Sbi-III, Sbi-IV inhibits the alternative pathway without complement consumption. The structure of Sbi-IV consists of a three-helix bundle fold.


:

Pssm-ID: 288473 [Multi-domain]  Cd Length: 69  Bit Score: 121.12  E-value: 1.00e-33
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1793149924 198 VSIEKAIVRHDERVKSANDAISKLNEKDSIENRRLAQREVNKAPMDVKEHLQKQLDALVAQKDAEKKVA 266
Cdd:pfam11621   1 VSIEKAIVRHDERVKSANDAISKLNEKDSIENRRLAQREVNKAPMDVKEHLQKQLDALVAQKDAEKKVA 69
B pfam02216
B domain; This family contains the B domain of Staphylococcal protein A, which specifically ...
98-148 1.37e-16

B domain; This family contains the B domain of Staphylococcal protein A, which specifically binds to the Fc portion of immunoglobulin G.


:

Pssm-ID: 396685 [Multi-domain]  Cd Length: 51  Bit Score: 73.35  E-value: 1.37e-16
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1793149924  98 DRRVAQQNAFYSVLKNDNLTEQEKNNYIAQIKENPDRSQQVWVESVQSSKA 148
Cdd:pfam02216   1 DYNKAQQNAFYQVLHLPNLNEEQRNGFIQSLKDDPSQSQNVLGEAKKLNDS 51
B pfam02216
B domain; This family contains the B domain of Staphylococcal protein A, which specifically ...
46-95 3.17e-16

B domain; This family contains the B domain of Staphylococcal protein A, which specifically binds to the Fc portion of immunoglobulin G.


:

Pssm-ID: 396685 [Multi-domain]  Cd Length: 51  Bit Score: 72.19  E-value: 3.17e-16
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1793149924  46 NYVTDQQKAFYQVLHLKGITEEQRNQYIKTLREHPERAQEVFSESLKDSK 95
Cdd:pfam02216   1 DYNKAQQNAFYQVLHLPNLNEEQRNGFIQSLKDDPSQSQNVLGEAKKLND 50
 
Name Accession Description Interval E-value
Sbi-IV pfam11621
C3 binding domain 4 of IgG-bind protein SBI; This family of proteins represents Sbi domain IV ...
198-266 1.00e-33

C3 binding domain 4 of IgG-bind protein SBI; This family of proteins represents Sbi domain IV which binds the central complement protein C3. Sbi-IV interacts with Sbi-III to induce a consumption of complement via alternative pathway activation. When not interacting with Sbi-III, Sbi-IV inhibits the alternative pathway without complement consumption. The structure of Sbi-IV consists of a three-helix bundle fold.


Pssm-ID: 288473 [Multi-domain]  Cd Length: 69  Bit Score: 121.12  E-value: 1.00e-33
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1793149924 198 VSIEKAIVRHDERVKSANDAISKLNEKDSIENRRLAQREVNKAPMDVKEHLQKQLDALVAQKDAEKKVA 266
Cdd:pfam11621   1 VSIEKAIVRHDERVKSANDAISKLNEKDSIENRRLAQREVNKAPMDVKEHLQKQLDALVAQKDAEKKVA 69
B pfam02216
B domain; This family contains the B domain of Staphylococcal protein A, which specifically ...
98-148 1.37e-16

B domain; This family contains the B domain of Staphylococcal protein A, which specifically binds to the Fc portion of immunoglobulin G.


Pssm-ID: 396685 [Multi-domain]  Cd Length: 51  Bit Score: 73.35  E-value: 1.37e-16
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1793149924  98 DRRVAQQNAFYSVLKNDNLTEQEKNNYIAQIKENPDRSQQVWVESVQSSKA 148
Cdd:pfam02216   1 DYNKAQQNAFYQVLHLPNLNEEQRNGFIQSLKDDPSQSQNVLGEAKKLNDS 51
B pfam02216
B domain; This family contains the B domain of Staphylococcal protein A, which specifically ...
46-95 3.17e-16

B domain; This family contains the B domain of Staphylococcal protein A, which specifically binds to the Fc portion of immunoglobulin G.


Pssm-ID: 396685 [Multi-domain]  Cd Length: 51  Bit Score: 72.19  E-value: 3.17e-16
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1793149924  46 NYVTDQQKAFYQVLHLKGITEEQRNQYIKTLREHPERAQEVFSESLKDSK 95
Cdd:pfam02216   1 DYNKAQQNAFYQVLHLPNLNEEQRNGFIQSLKDDPSQSQNVLGEAKKLND 50
 
Name Accession Description Interval E-value
Sbi-IV pfam11621
C3 binding domain 4 of IgG-bind protein SBI; This family of proteins represents Sbi domain IV ...
198-266 1.00e-33

C3 binding domain 4 of IgG-bind protein SBI; This family of proteins represents Sbi domain IV which binds the central complement protein C3. Sbi-IV interacts with Sbi-III to induce a consumption of complement via alternative pathway activation. When not interacting with Sbi-III, Sbi-IV inhibits the alternative pathway without complement consumption. The structure of Sbi-IV consists of a three-helix bundle fold.


Pssm-ID: 288473 [Multi-domain]  Cd Length: 69  Bit Score: 121.12  E-value: 1.00e-33
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1793149924 198 VSIEKAIVRHDERVKSANDAISKLNEKDSIENRRLAQREVNKAPMDVKEHLQKQLDALVAQKDAEKKVA 266
Cdd:pfam11621   1 VSIEKAIVRHDERVKSANDAISKLNEKDSIENRRLAQREVNKAPMDVKEHLQKQLDALVAQKDAEKKVA 69
B pfam02216
B domain; This family contains the B domain of Staphylococcal protein A, which specifically ...
98-148 1.37e-16

B domain; This family contains the B domain of Staphylococcal protein A, which specifically binds to the Fc portion of immunoglobulin G.


Pssm-ID: 396685 [Multi-domain]  Cd Length: 51  Bit Score: 73.35  E-value: 1.37e-16
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1793149924  98 DRRVAQQNAFYSVLKNDNLTEQEKNNYIAQIKENPDRSQQVWVESVQSSKA 148
Cdd:pfam02216   1 DYNKAQQNAFYQVLHLPNLNEEQRNGFIQSLKDDPSQSQNVLGEAKKLNDS 51
B pfam02216
B domain; This family contains the B domain of Staphylococcal protein A, which specifically ...
46-95 3.17e-16

B domain; This family contains the B domain of Staphylococcal protein A, which specifically binds to the Fc portion of immunoglobulin G.


Pssm-ID: 396685 [Multi-domain]  Cd Length: 51  Bit Score: 72.19  E-value: 3.17e-16
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1793149924  46 NYVTDQQKAFYQVLHLKGITEEQRNQYIKTLREHPERAQEVFSESLKDSK 95
Cdd:pfam02216   1 DYNKAQQNAFYQVLHLPNLNEEQRNGFIQSLKDDPSQSQNVLGEAKKLND 50
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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