|
Name |
Accession |
Description |
Interval |
E-value |
| leuB |
TIGR00169 |
3-isopropylmalate dehydrogenase; Several NAD- or NADP-dependent dehydrogenases, including ... |
4-352 |
0e+00 |
|
3-isopropylmalate dehydrogenase; Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the dimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates.Among these decarboxylating dehydrogenases of hydroxyacids, overall sequence homology indicates evolutionary history rather than actual substrate or cofactor specifity, which may be toggled experimentally by replacement of just a few amino acids. 3-isopropylmalate dehydrogenase is an NAD-dependent enzyme and should have a sequence resembling HGSAPDI around residue 340. The subtrate binding loop should include a sequence resembling E[KQR]X(0,1)LLXXR around residue 115. Other contacts of importance are known from crystallography but not detailed here.This model will not find all isopropylmalate dehydrogenases; the enzyme from Sulfolobus sp. strain 7 is more similar to mitochondrial NAD-dependent isocitrate dehydrogenases than to other known isopropylmalate dehydrogenases and was omitted to improve the specificity of the model. It scores below the cutoff and below some enzymes known not to be isopropylmalate dehydrogenase. [Amino acid biosynthesis, Pyruvate family]
Pssm-ID: 272939 Cd Length: 346 Bit Score: 543.53 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2855 4 NIVVLPGDHVGKEVTDEAIKVLNAIAEvRPEIKFNFQHHLIGGAAIDATGTPLPDEALEASKKADAVLLGAVGGPKWGTG 83
Cdd:TIGR00169 1 KIAVLPGDGIGPEVMAQALKVLKAVAE-RFGLKFEFEEHLIGGAAIDATGQPLPEETLKGCKEADAVLLGAVGGPKWDNL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2855 84 A--VRPEQGLLKIRKELGLYANLRPCNFAsDSLLDLSPLKPEYAKGTDFVVVRELVGGIYFGERKEDEGDGVAWDSEKYS 161
Cdd:TIGR00169 80 PrdQRPEQGLLKLRKSLDLFANLRPAKVF-PGLEDLSPLKEEIAKGVDFVVVRELTGGIYFGEPKGREGEGEAWDTEVYT 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2855 162 VPEVQRITRMAAFLALQQNPplPIWSLDKANVLASSRLWRKTVEETIKtEFPQLTVQHQLIDSAAMILVKSPTKLNgVVI 241
Cdd:TIGR00169 159 VPEIERIARVAFEMARKRRK--KVTSVDKANVLESSRLWRKTVEEIAK-EYPDVELEHQYIDNAAMQLVKSPTQFD-VVV 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2855 242 TNNMFGDIISDEASVIPGSLGLLPSASLASlpdtnKAFGLYEPCHGSAPDLPANKV-NPIATILSAAMMLKLSLDLVEEG 320
Cdd:TIGR00169 235 TSNLFGDILSDEASVITGSLGMLPSASLGS-----DGFGLFEPVHGSAPDIAGKGIaNPIAQILSAAMLLRYSFNLEEAA 309
|
330 340 350
....*....|....*....|....*....|..
gi 2855 321 RALEEAVRNVLDAGVRTGDLGGsNSTTEVGDA 352
Cdd:TIGR00169 310 DAIEAAVKKVLAEGYRTPDLGS-SATTAVGTA 340
|
|
| PRK00772 |
PRK00772 |
3-isopropylmalate dehydrogenase; Provisional |
1-359 |
1.20e-177 |
|
3-isopropylmalate dehydrogenase; Provisional
Pssm-ID: 234832 Cd Length: 358 Bit Score: 496.93 E-value: 1.20e-177
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2855 1 MSKNIVVLPGDHVGKEVTDEAIKVLNAIAEvRPEIKFNFQHHLIGGAAIDATGTPLPDEALEASKKADAVLLGAVGGPKW 80
Cdd:PRK00772 1 MTYKIAVLPGDGIGPEVMAEAVKVLDAVAE-KFGFDFEFEEALVGGAAIDAHGVPLPEETLEACRAADAVLLGAVGGPKW 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2855 81 GT--GAVRPEQGLLKIRKELGLYANLRPCNFAsDSLLDLSPLKPEYAKGTDFVVVRELVGGIYFGE---RKEDEGDGVAW 155
Cdd:PRK00772 80 DNlpPDVRPERGLLALRKELGLFANLRPAKLY-PGLADASPLKPEIVAGLDILIVRELTGGIYFGEprgREGLGGEERAF 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2855 156 DSEKYSVPEVQRITRMAAFLALQQNPPLPiwSLDKANVLASSRLWRKTVEEtIKTEFPQLTVQHQLIDSAAMILVKSPTK 235
Cdd:PRK00772 159 DTMVYTREEIERIARVAFELARKRRKKVT--SVDKANVLESSRLWREVVTE-VAKEYPDVELSHMYVDNAAMQLVRNPKQ 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2855 236 LnGVVITNNMFGDIISDEASVIPGSLGLLPSASLASlpdtnKAFGLYEPCHGSAPDLpA--NKVNPIATILSAAMMLKLS 313
Cdd:PRK00772 236 F-DVIVTENLFGDILSDEAAMLTGSLGMLPSASLGE-----SGPGLYEPIHGSAPDI-AgkGIANPIATILSAAMMLRYS 308
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 2855 314 LDLVEEGRALEEAVRNVLDAGVRTGDL---GGSNSTTEVGDAIAKAVKE 359
Cdd:PRK00772 309 LGLEEAADAIEAAVEKVLAQGYRTADIaegGGKVSTSEMGDAILAALAE 357
|
|
| Iso_dh |
pfam00180 |
Isocitrate/isopropylmalate dehydrogenase; |
4-353 |
4.38e-167 |
|
Isocitrate/isopropylmalate dehydrogenase;
Pssm-ID: 425507 Cd Length: 346 Bit Score: 469.85 E-value: 4.38e-167
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2855 4 NIVVLPGDHVGKEVTDEAIKVLNAIAEVRPEiKFNFQHHLIGGAAIDATGTPLPDEALEASKKADAVLLGAVGGPKWGTG 83
Cdd:pfam00180 1 KIAVLPGDGIGPEVMAAALKVLKAALEKAPL-EFEFEERDVGGAAIDETGEPLPDETLEACKKADAVLLGAVGGPKWDPA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2855 84 AVRPEQGLLKIRKELGLYANLRPCNFASdSLLDLSPLKPEyAKGTDFVVVRELVGGIYFGERKEDEGDG--VAWDSEKYS 161
Cdd:pfam00180 80 GVRPENGLLALRKELGLFANLRPAKVFP-PLGDASPLKNE-VEGVDIVIVRELTGGIYFGIEKGIKGSGneVAVDTKLYS 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2855 162 VPEVQRITRMAAFLALQQNPPlPIWSLDKANVLASSRLWRKTVEETIKTEFPQLTVQHQLIDSAAMILVKSPtKLNGVVI 241
Cdd:pfam00180 158 RDEIERIARVAFELARKRGRK-KVTSVDKANVLKSSDLWRKIVTEVAKAEYPDVELEHQLVDNAAMQLVKNP-SQFDVIV 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2855 242 TNNMFGDIISDEASVIPGSLGLLPSASLASlpdtnKAFGLYEPCHGSAPDLPA-NKVNPIATILSAAMMLKLSLDLVEEG 320
Cdd:pfam00180 236 TPNLFGDILSDEASMLTGSLGLLPSASLGA-----NGFGIFEPVHGSAPDIAGkGIANPIATILSAAMMLRYSLGLEDAA 310
|
330 340 350
....*....|....*....|....*....|....*.
gi 2855 321 RALEEAVRNVLDAGVRTGDLGGSN---STTEVGDAI 353
Cdd:pfam00180 311 DKIEAAVLKVLESGIRTGDLAGSAtyvSTSEFGEAV 346
|
|
| LeuB |
COG0473 |
Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid ... |
2-357 |
1.74e-159 |
|
Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid transport and metabolism]; Isocitrate/isopropylmalate dehydrogenase is part of the Pathway/BioSystem: TCA cycle
Pssm-ID: 440241 Cd Length: 346 Bit Score: 450.62 E-value: 1.74e-159
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2855 2 SKNIVVLPGDHVGKEVTDEAIKVLNAIAEvRPEIKFNFQHHLIGGAAIDATGTPLPDEALEASKKADAVLLGAVGGPKWG 81
Cdd:COG0473 1 TYKIAVLPGDGIGPEVVAAALKVLEAAAE-RFGLDFEFEEADIGGAAYDKTGTPLPDETLEALRKADAILLGAVGGPKWD 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2855 82 TGaVRPEQGLLKIRKELGLYANLRPCnfasdSLLD--LSPLKPEYAKGTDFVVVRELVGGIYFGE---RKEDEGDGVAWD 156
Cdd:COG0473 80 DG-VRPESGLLALRKELDLYANLRPA-----KLYPglPSPLKPEIVEGIDLVIVRENTEGLYFGIggrIGTGTGEEVAID 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2855 157 SEKYSVPEVQRITRMAAFLALQQNPPLpiWSLDKANVLA-SSRLWRKTVEEtIKTEFPQLTVQHQLIDSAAMILVKSPTK 235
Cdd:COG0473 154 TRVYTRKGIERIARYAFELARKRRKKV--TSVDKANVLKlTSGLWREVVRE-VAKEYPDVELDHMYVDAAAMQLVRNPEQ 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2855 236 LNgVVITNNMFGDIISDEASVIPGSLGLLPSASLASlpdtnKAFGLYEPCHGSAPDLpA--NKVNPIATILSAAMMLKLs 313
Cdd:COG0473 231 FD-VIVTENLFGDILSDLAAGLTGSLGLAPSANIGD-----EGKALFEPVHGSAPDI-AgkGIANPIATILSAAMMLRH- 302
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 2855 314 LDLVEEGRALEEAVRNVLDAGVRTGDLGGSNSTTEVGDAIAKAV 357
Cdd:COG0473 303 LGEEEAADAIEAAVEKVLAEGVRTPDLGGKAGTSEMGDAIIAAL 346
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| leuB |
TIGR00169 |
3-isopropylmalate dehydrogenase; Several NAD- or NADP-dependent dehydrogenases, including ... |
4-352 |
0e+00 |
|
3-isopropylmalate dehydrogenase; Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the dimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates.Among these decarboxylating dehydrogenases of hydroxyacids, overall sequence homology indicates evolutionary history rather than actual substrate or cofactor specifity, which may be toggled experimentally by replacement of just a few amino acids. 3-isopropylmalate dehydrogenase is an NAD-dependent enzyme and should have a sequence resembling HGSAPDI around residue 340. The subtrate binding loop should include a sequence resembling E[KQR]X(0,1)LLXXR around residue 115. Other contacts of importance are known from crystallography but not detailed here.This model will not find all isopropylmalate dehydrogenases; the enzyme from Sulfolobus sp. strain 7 is more similar to mitochondrial NAD-dependent isocitrate dehydrogenases than to other known isopropylmalate dehydrogenases and was omitted to improve the specificity of the model. It scores below the cutoff and below some enzymes known not to be isopropylmalate dehydrogenase. [Amino acid biosynthesis, Pyruvate family]
Pssm-ID: 272939 Cd Length: 346 Bit Score: 543.53 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2855 4 NIVVLPGDHVGKEVTDEAIKVLNAIAEvRPEIKFNFQHHLIGGAAIDATGTPLPDEALEASKKADAVLLGAVGGPKWGTG 83
Cdd:TIGR00169 1 KIAVLPGDGIGPEVMAQALKVLKAVAE-RFGLKFEFEEHLIGGAAIDATGQPLPEETLKGCKEADAVLLGAVGGPKWDNL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2855 84 A--VRPEQGLLKIRKELGLYANLRPCNFAsDSLLDLSPLKPEYAKGTDFVVVRELVGGIYFGERKEDEGDGVAWDSEKYS 161
Cdd:TIGR00169 80 PrdQRPEQGLLKLRKSLDLFANLRPAKVF-PGLEDLSPLKEEIAKGVDFVVVRELTGGIYFGEPKGREGEGEAWDTEVYT 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2855 162 VPEVQRITRMAAFLALQQNPplPIWSLDKANVLASSRLWRKTVEETIKtEFPQLTVQHQLIDSAAMILVKSPTKLNgVVI 241
Cdd:TIGR00169 159 VPEIERIARVAFEMARKRRK--KVTSVDKANVLESSRLWRKTVEEIAK-EYPDVELEHQYIDNAAMQLVKSPTQFD-VVV 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2855 242 TNNMFGDIISDEASVIPGSLGLLPSASLASlpdtnKAFGLYEPCHGSAPDLPANKV-NPIATILSAAMMLKLSLDLVEEG 320
Cdd:TIGR00169 235 TSNLFGDILSDEASVITGSLGMLPSASLGS-----DGFGLFEPVHGSAPDIAGKGIaNPIAQILSAAMLLRYSFNLEEAA 309
|
330 340 350
....*....|....*....|....*....|..
gi 2855 321 RALEEAVRNVLDAGVRTGDLGGsNSTTEVGDA 352
Cdd:TIGR00169 310 DAIEAAVKKVLAEGYRTPDLGS-SATTAVGTA 340
|
|
| PRK00772 |
PRK00772 |
3-isopropylmalate dehydrogenase; Provisional |
1-359 |
1.20e-177 |
|
3-isopropylmalate dehydrogenase; Provisional
Pssm-ID: 234832 Cd Length: 358 Bit Score: 496.93 E-value: 1.20e-177
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2855 1 MSKNIVVLPGDHVGKEVTDEAIKVLNAIAEvRPEIKFNFQHHLIGGAAIDATGTPLPDEALEASKKADAVLLGAVGGPKW 80
Cdd:PRK00772 1 MTYKIAVLPGDGIGPEVMAEAVKVLDAVAE-KFGFDFEFEEALVGGAAIDAHGVPLPEETLEACRAADAVLLGAVGGPKW 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2855 81 GT--GAVRPEQGLLKIRKELGLYANLRPCNFAsDSLLDLSPLKPEYAKGTDFVVVRELVGGIYFGE---RKEDEGDGVAW 155
Cdd:PRK00772 80 DNlpPDVRPERGLLALRKELGLFANLRPAKLY-PGLADASPLKPEIVAGLDILIVRELTGGIYFGEprgREGLGGEERAF 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2855 156 DSEKYSVPEVQRITRMAAFLALQQNPPLPiwSLDKANVLASSRLWRKTVEEtIKTEFPQLTVQHQLIDSAAMILVKSPTK 235
Cdd:PRK00772 159 DTMVYTREEIERIARVAFELARKRRKKVT--SVDKANVLESSRLWREVVTE-VAKEYPDVELSHMYVDNAAMQLVRNPKQ 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2855 236 LnGVVITNNMFGDIISDEASVIPGSLGLLPSASLASlpdtnKAFGLYEPCHGSAPDLpA--NKVNPIATILSAAMMLKLS 313
Cdd:PRK00772 236 F-DVIVTENLFGDILSDEAAMLTGSLGMLPSASLGE-----SGPGLYEPIHGSAPDI-AgkGIANPIATILSAAMMLRYS 308
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 2855 314 LDLVEEGRALEEAVRNVLDAGVRTGDL---GGSNSTTEVGDAIAKAVKE 359
Cdd:PRK00772 309 LGLEEAADAIEAAVEKVLAQGYRTADIaegGGKVSTSEMGDAILAALAE 357
|
|
| Iso_dh |
pfam00180 |
Isocitrate/isopropylmalate dehydrogenase; |
4-353 |
4.38e-167 |
|
Isocitrate/isopropylmalate dehydrogenase;
Pssm-ID: 425507 Cd Length: 346 Bit Score: 469.85 E-value: 4.38e-167
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2855 4 NIVVLPGDHVGKEVTDEAIKVLNAIAEVRPEiKFNFQHHLIGGAAIDATGTPLPDEALEASKKADAVLLGAVGGPKWGTG 83
Cdd:pfam00180 1 KIAVLPGDGIGPEVMAAALKVLKAALEKAPL-EFEFEERDVGGAAIDETGEPLPDETLEACKKADAVLLGAVGGPKWDPA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2855 84 AVRPEQGLLKIRKELGLYANLRPCNFASdSLLDLSPLKPEyAKGTDFVVVRELVGGIYFGERKEDEGDG--VAWDSEKYS 161
Cdd:pfam00180 80 GVRPENGLLALRKELGLFANLRPAKVFP-PLGDASPLKNE-VEGVDIVIVRELTGGIYFGIEKGIKGSGneVAVDTKLYS 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2855 162 VPEVQRITRMAAFLALQQNPPlPIWSLDKANVLASSRLWRKTVEETIKTEFPQLTVQHQLIDSAAMILVKSPtKLNGVVI 241
Cdd:pfam00180 158 RDEIERIARVAFELARKRGRK-KVTSVDKANVLKSSDLWRKIVTEVAKAEYPDVELEHQLVDNAAMQLVKNP-SQFDVIV 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2855 242 TNNMFGDIISDEASVIPGSLGLLPSASLASlpdtnKAFGLYEPCHGSAPDLPA-NKVNPIATILSAAMMLKLSLDLVEEG 320
Cdd:pfam00180 236 TPNLFGDILSDEASMLTGSLGLLPSASLGA-----NGFGIFEPVHGSAPDIAGkGIANPIATILSAAMMLRYSLGLEDAA 310
|
330 340 350
....*....|....*....|....*....|....*.
gi 2855 321 RALEEAVRNVLDAGVRTGDLGGSN---STTEVGDAI 353
Cdd:pfam00180 311 DKIEAAVLKVLESGIRTGDLAGSAtyvSTSEFGEAV 346
|
|
| LeuB |
COG0473 |
Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid ... |
2-357 |
1.74e-159 |
|
Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid transport and metabolism]; Isocitrate/isopropylmalate dehydrogenase is part of the Pathway/BioSystem: TCA cycle
Pssm-ID: 440241 Cd Length: 346 Bit Score: 450.62 E-value: 1.74e-159
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2855 2 SKNIVVLPGDHVGKEVTDEAIKVLNAIAEvRPEIKFNFQHHLIGGAAIDATGTPLPDEALEASKKADAVLLGAVGGPKWG 81
Cdd:COG0473 1 TYKIAVLPGDGIGPEVVAAALKVLEAAAE-RFGLDFEFEEADIGGAAYDKTGTPLPDETLEALRKADAILLGAVGGPKWD 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2855 82 TGaVRPEQGLLKIRKELGLYANLRPCnfasdSLLD--LSPLKPEYAKGTDFVVVRELVGGIYFGE---RKEDEGDGVAWD 156
Cdd:COG0473 80 DG-VRPESGLLALRKELDLYANLRPA-----KLYPglPSPLKPEIVEGIDLVIVRENTEGLYFGIggrIGTGTGEEVAID 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2855 157 SEKYSVPEVQRITRMAAFLALQQNPPLpiWSLDKANVLA-SSRLWRKTVEEtIKTEFPQLTVQHQLIDSAAMILVKSPTK 235
Cdd:COG0473 154 TRVYTRKGIERIARYAFELARKRRKKV--TSVDKANVLKlTSGLWREVVRE-VAKEYPDVELDHMYVDAAAMQLVRNPEQ 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2855 236 LNgVVITNNMFGDIISDEASVIPGSLGLLPSASLASlpdtnKAFGLYEPCHGSAPDLpA--NKVNPIATILSAAMMLKLs 313
Cdd:COG0473 231 FD-VIVTENLFGDILSDLAAGLTGSLGLAPSANIGD-----EGKALFEPVHGSAPDI-AgkGIANPIATILSAAMMLRH- 302
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 2855 314 LDLVEEGRALEEAVRNVLDAGVRTGDLGGSNSTTEVGDAIAKAV 357
Cdd:COG0473 303 LGEEEAADAIEAAVEKVLAEGVRTPDLGGKAGTSEMGDAIIAAL 346
|
|
| PLN02329 |
PLN02329 |
3-isopropylmalate dehydrogenase |
4-357 |
3.02e-88 |
|
3-isopropylmalate dehydrogenase
Pssm-ID: 215188 Cd Length: 409 Bit Score: 271.56 E-value: 3.02e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2855 4 NIVVLPGDHVGKEVTDEAIKVLNAIAEVRpEIKFNFQHHLIGGAAIDATGTPLPDEALEASKKADAVLLGAVGGPKWGTG 83
Cdd:PLN02329 48 NIALLPGDGIGPEVISVAKNVLQKAGSLE-GLEFDFQEMPVGGAALDLVGVPLPEETFTAAKQSDAILLGAIGGYKWDKN 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2855 84 A--VRPEQGLLKIRKELGLYANLRPCNFASdSLLDLSPLKPEYAKGTDFVVVRELVGGIYFGERK----EDEGDGVAWDS 157
Cdd:PLN02329 127 EkhLRPEMALFYLRRDLKVFANLRPATVLP-QLVDASTLKKEVAEGVDMMIVRELTGGIYFGEPRgitiNENGEEVGVST 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2855 158 EKYSVPEVQRITRMAAFLALQQNPPLpiWSLDKANVLASSRLWRKTVeETIKTEFPQLTVQHQLIDSAAMILVKSPTKLN 237
Cdd:PLN02329 206 EIYAAHEIDRIARVAFETARKRRGKL--CSVDKANVLDASILWRKRV-TALASEYPDVELSHMYVDNAAMQLIRDPKQFD 282
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2855 238 gVVITNNMFGDIISDEASVIPGSLGLLPSASL-ASLPdtnkafGLYEPCHGSAPDLPA-NKVNPIATILSAAMMLKLSLD 315
Cdd:PLN02329 283 -TIVTNNIFGDILSDEASMITGSIGMLPSASLgESGP------GLFEPIHGSAPDIAGqDKANPLATILSAAMLLKYGLG 355
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 2855 316 LVEEGRALEEAVRNVLDAGVRTGDLGGSNST----TEVGDAIAKAV 357
Cdd:PLN02329 356 EEKAAKRIEDAVVDALNKGFRTGDIYSPGNKlvgcKEMGEEVLKSV 401
|
|
| PRK14025 |
PRK14025 |
multifunctional 3-isopropylmalate dehydrogenase/D-malate dehydrogenase; Provisional |
2-357 |
9.52e-70 |
|
multifunctional 3-isopropylmalate dehydrogenase/D-malate dehydrogenase; Provisional
Pssm-ID: 184462 Cd Length: 330 Bit Score: 221.55 E-value: 9.52e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2855 2 SKNIVVLPGDHVGKEVTDEAIKVLNAIaevrpEIKFNFQHHLIGGAAIDATGTPLPDEALEASKKADAVLLGAVGgpkwg 81
Cdd:PRK14025 1 MHKICVIEGDGIGKEVVPAALHVLEAT-----GLPFEFVYAEAGDEVFEKTGKALPEETIEAAKEADAVLFGAAG----- 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2855 82 tgaVRPEQGLLKIRKELGLYANLRPCNfasdSLLDLSPLKPeyakGTDFVVVRELVGGIYFGErKEDEGDGVAWDSEKYS 161
Cdd:PRK14025 71 ---ETAADVIVKLRRILDTYANVRPVK----SYKGVKCLYP----DIDYVIVRENTEGLYKGI-EAEIADGVTVATRVIT 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2855 162 VPEVQRITRMAAFLALQQNPPL---PIWSLDKANVLA-SSRLWRKTVEEtIKTEFPQLTVQHQLIDSAAMILVKSPTKLN 237
Cdd:PRK14025 139 RKASERIFRFAFEMAKRRKKMGkegKVTCAHKANVLKkTDGLFKKTFYE-VAKEYPDIKAEDYYVDAMNMYIITRPQTFD 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2855 238 gVVITNNMFGDIISDEASVIPGSLGLLPSASLAslpdtnKAFGLYEPCHGSAPDLPANKV-NPIATILSAAMMLKlSLDL 316
Cdd:PRK14025 218 -VVVTSNLFGDILSDGAAGLVGGLGLAPSANIG------DKYGLFEPVHGSAPDIAGKGIaNPTATILTAVLMLR-HLGE 289
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 2855 317 VEEGRALEEAVRNVLDAGVRTGDLGGSNSTTEVGDAIAKAV 357
Cdd:PRK14025 290 NEEADKVEKALEEVLALGLTTPDLGGNLSTMEMAEEVAKRV 330
|
|
| PRK03437 |
PRK03437 |
3-isopropylmalate dehydrogenase; Provisional |
1-357 |
6.46e-68 |
|
3-isopropylmalate dehydrogenase; Provisional
Pssm-ID: 179579 Cd Length: 344 Bit Score: 217.10 E-value: 6.46e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2855 1 MSKNIVVLPGDHVGKEVTDEAIKVLNAIAEVRPEIKFNfqHHLIGGAAIDATGTPLPDEALEASKKADAVLLGAVGGPKW 80
Cdd:PRK03437 3 KTMKLAVIPGDGIGPEVVAEALKVLDAVAAGGPGVETT--EYDLGARRYLRTGETLPDSVLAELRQHDAILLGAIGDPSV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2855 81 GTGAVrpEQG-LLKIRKELGLYANLRPCNFASDSlldLSPLK-PEyakGTDFVVVRELVGGIYFGE----RK--EDEgdg 152
Cdd:PRK03437 81 PSGVL--ERGlLLKLRFALDHYVNLRPSKLYPGV---TSPLAgPG---DIDFVVVREGTEGPYTGNggalRVgtPHE--- 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2855 153 VAWDSEKYSVPEVQRITRMaAFLALQQNPPLPIWSLDKANVLA-SSRLWRKTVEEtIKTEFPQLTVQHQLIDSAAMILVK 231
Cdd:PRK03437 150 VATEVSVNTAFGVERVVRD-AFERAQKRPRKHLTLVHKTNVLTfAGDLWQRTVDE-VAAEYPDVTVDYQHVDAATIFMVT 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2855 232 SPTKLNgVVITNNMFGDIISDEASVIPGSLGLlpsASLASLPDTNKAFGLYEPCHGSAPDLPA-NKVNPIATILSAAMML 310
Cdd:PRK03437 228 DPSRFD-VIVTDNLFGDIITDLAAAVTGGIGL---AASGNINPTGTNPSMFEPVHGSAPDIAGqGIADPTAAILSVALLL 303
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 2855 311 KlSLDLVEEGRALEEAVRNVLdagvrTGDLGGSNSTTEVGDAIAKAV 357
Cdd:PRK03437 304 D-HLGEEDAAARIEAAVEADL-----AERGKMGRSTAEVGDRIAARL 344
|
|
| PRK08194 |
PRK08194 |
tartrate dehydrogenase; Provisional |
4-360 |
3.13e-58 |
|
tartrate dehydrogenase; Provisional
Pssm-ID: 181281 Cd Length: 352 Bit Score: 192.24 E-value: 3.13e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2855 4 NIVVLPGDHVGKEVTDEAIKVLNAIAEVRPEIKFNFQHHLIGGAAIDATGTPLPDEALEASKKADAVLLGAVGGPK---- 79
Cdd:PRK08194 5 KIAVIPGDGVGKEVVPAAVRVLKAVAEVHGGLKFEFTEFPWSCEYYLEHGEMMPEDGLEQLKQFDAIFLGAVGNPKlvpd 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2855 80 ----WGTgavrpeqgLLKIRKELGLYANLRPCNFASDSlldLSPLKpeYAKGTDFVVVRELVGGIY--FGERKEDEGDGV 153
Cdd:PRK08194 85 hislWGL--------LIKIRREFEQVINIRPAKQLRGI---KSPLA--NPKDFDLLVVRENSEGEYseVGGRIHRGEDEI 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2855 154 AWDSEKYSVPEVQRITRMAAFLAlqQNPPLPIWSLDKAN-VLASSRLWRKTVEETIKtEFPQLTVQHQLIDSAAMILVKS 232
Cdd:PRK08194 152 AIQNAVFTRKGTERAMRYAFELA--AKRRKHVTSATKSNgIVHSMPFWDEVFQEVGK-DYPEIETDSQHIDALAAFFVTR 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2855 233 PTKLNgVVITNNMFGDIISDEASVIPGSLGLLPSASLASlpdTNKAFGLYEPCHGSAPDLPANKV-NPIATILSAAMMLK 311
Cdd:PRK08194 229 PEEFD-VIVASNLFGDILTDIGAAIMGSIGIAPAANINV---NGKYPSMFEPVHGSAPDIAGKGIaNPIGQIWTAKLMLD 304
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 2855 312 lSLDLVEEGRALEEAVRNVLDAGVRTGDLGGSNSTTEVGDAIAKAVKEI 360
Cdd:PRK08194 305 -HFGEEELGSHLLDVIEDVTEDGIKTPDIGGRATTDEVTDEIISRLKKL 352
|
|
| PRK08997 |
PRK08997 |
isocitrate dehydrogenase; Provisional |
1-354 |
4.22e-50 |
|
isocitrate dehydrogenase; Provisional
Pssm-ID: 181606 Cd Length: 334 Bit Score: 170.67 E-value: 4.22e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2855 1 MSKNIVVLPGDHVGKEVTDEAIKVLNAIaevrpEIKFNFQHHLIGGAAIDATGTPLPDEALEASKKADAVLLGAVGGPKw 80
Cdd:PRK08997 1 MKQTITVIPGDGIGPSIIDATLKILDKL-----GCDFEYEFADAGLTALEKHGELLPQRTLDLIEKNKIALKGPLTTPV- 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2855 81 GTGAVRPEQGLlkiRKELGLYANLRPcnfasdsLLDLSPLKPEYAkGTDFVVVRELVGGIYFGERKEDEGDG-VAWDSEK 159
Cdd:PRK08997 75 GEGFTSINVTL---RKKFDLYANVRP-------VLSFPGTKARYD-NIDIITVRENTEGMYSGEGQTVSEDGeTAEATSI 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2855 160 YSVPEVQRITRMAAFLALQQNPPlPIWSLDKANVLAS-SRLWRKTVEEtIKTEFPQLTVQHQLIDSAAMILVKSPTKLNg 238
Cdd:PRK08997 144 ITRKGAERIVRFAYELARKEGRK-KVTAVHKANIMKStSGLFLKVARE-VALRYPDIEFEEMIVDATCMQLVMNPEQFD- 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2855 239 VVITNNMFGDIISDEASVIPGSLGLLPSASLAslpdtnKAFGLYEPCHGSAPDLPA-NKVNPIATILSAAMMLKlSLDLV 317
Cdd:PRK08997 221 VIVTTNLFGDILSDLCAGLVGGLGMAPGANIG------RDAAIFEAVHGSAPDIAGkNLANPTSVILAAIQMLE-YLGMP 293
|
330 340 350
....*....|....*....|....*....|....*...
gi 2855 318 EEGRALEEAVRNVLDAGVR-TGDLGGSNSTTEVGDAIA 354
Cdd:PRK08997 294 DKAERIRKAIVAVIEAGDRtTRDLGGTHGTTDFTQAVI 331
|
|
| PLN00118 |
PLN00118 |
isocitrate dehydrogenase (NAD+) |
7-353 |
7.63e-38 |
|
isocitrate dehydrogenase (NAD+)
Pssm-ID: 215062 Cd Length: 372 Bit Score: 139.24 E-value: 7.63e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2855 7 VLPGDHVGKEVTDEAIKVLNAIaevrpEIKFNFQHHLIGGAAIDATGTPLPDEALEASKKADAVLLGAVGGPkWGTGavr 86
Cdd:PLN00118 46 LFPGDGIGPEIAESVKQVFTAA-----GVPIEWEEHYVGTTVDPRTGSFLTWESLESVRRNKVGLKGPMATP-IGKG--- 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2855 87 pEQGL-LKIRKELGLYANLRPCnfasdslLDLSPLKPEYaKGTDFVVVRelvggiyfgERKEDEGDGVAWDSEKYSVPEV 165
Cdd:PLN00118 117 -HRSLnLTLRKELGLYANVRPC-------YSLPGYKTRY-DDVDLVTIR---------ENTEGEYSGLEHQVVRGVVESL 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2855 166 QRITRMA-------AFLALQQNPPLPIWSLDKANVLASSR-LWRKTVEEtIKTEFPQLTVQHQLIDSAAMILVKSPTKLN 237
Cdd:PLN00118 179 KIITRQAslrvaeyAFHYAKTHGRKRVSAIHKANIMKKTDgLFLKCCRE-VAEKYPEIVYEEVIIDNCCMMLVKNPALFD 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2855 238 gVVITNNMFGDIISDEASVIPGSLGLLPSASLAslpdtNKAFGLYEPCHGSAPDLPA-NKVNPIATILSAAMMLKlSLDL 316
Cdd:PLN00118 258 -VLVMPNLYGDIISDLCAGLIGGLGLTPSCNIG-----ENGLALAEAVHGSAPDIAGkNLANPTALLLSAVMMLR-HLKL 330
|
330 340 350
....*....|....*....|....*....|....*...
gi 2855 317 VEEGRALEEAVRNVLDAG-VRTGDLGGSNSTTEVGDAI 353
Cdd:PLN00118 331 NEQAEQIHNAILNTIAEGkYRTADLGGSSTTTDFTKAI 368
|
|
| Icd |
COG0538 |
Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part ... |
5-355 |
2.91e-30 |
|
Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part of the Pathway/BioSystem: TCA cycle
Pssm-ID: 440304 Cd Length: 409 Bit Score: 119.45 E-value: 2.91e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2855 5 IVVLPGDHVGKEVTDEAIKVLNAIAEV--RPEIKFNFQHHLIGGAAIDATGTPLPDEALEASKKADAVLLGA----VGGp 78
Cdd:COG0538 21 IPFIEGDGIGPEITRAIWKVIDAAVEKayGGKRDIEWKEVDAGEKARDETGDWLPDETAEAIKEYGVGIKGPlttpVGG- 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2855 79 KW----GTgavrpeqgllkIRKELGLYANLRPCNFASDSLldlSPLK-PEYakgTDFVVVRELVGGIYFG--------ER 145
Cdd:COG0538 100 GWrslnVT-----------IRQILDLYVCRRPVRYFKGVP---SPVKhPEK---VDIVIFRENTEDIYAGiewkagspEA 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2855 146 KE-----DEGDGVawdsEKYSVPE-------------VQRITRMAAFLALQQNPPlPIWSLDKANVLassrlwrKTVE-- 205
Cdd:COG0538 163 LKlifflEDEMGV----TVIRFPEdsgigikpvsdegTERLVRAAIQYALDNKRK-SVTLVHKGNIM-------KFTEga 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2855 206 ------ETIKTEFP-------------------QLTVQHQLIDSAAMILVKSPTKLNgVVITNNMFGDIISDEASVIPGS 260
Cdd:COG0538 231 fkdwgyEVAEEEFGdkfitegpwekykgpkpagKIVYKDRIADDMLQQILLRPGEYD-VIATKNLNGDYISDALAAQVGG 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2855 261 LGLLPSASLAslPDTNkafGLYEPCHGSAPDLP-ANKVNPIATILSAAMMLKLsLDLVEEGRALEEAVRNVLDAGVRTGD 339
Cdd:COG0538 310 LGIAPGANIG--DDGG---AEFEATHGTAPKYAgKDSTNPGSLILSGTMMLRH-RGWLEAADLIEKAVEKTIESGKVTYD 383
|
410 420
....*....|....*....|..
gi 2855 340 L------GGSNSTTEVGDAIAK 355
Cdd:COG0538 384 LarlmegATELSTSEFGDAIIE 405
|
|
| PRK09222 |
PRK09222 |
NADP-dependent isocitrate dehydrogenase; |
1-357 |
2.84e-29 |
|
NADP-dependent isocitrate dehydrogenase;
Pssm-ID: 236416 [Multi-domain] Cd Length: 482 Bit Score: 117.68 E-value: 2.84e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2855 1 MSKNIVVLPGDHVGKEVTDEAIKVLNAI-AEVRPEI-----KFNFQHHLIGgaaidatgtpLPDEALEASKKADAVLLGA 74
Cdd:PRK09222 3 EKTPITVAYGDGIGPEIMEAVLKILEAAgAPLEIETieigeKVYKKGWTSG----------ISPSAWESIRRTKVLLKAP 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2855 75 VGGPKwGTGavrpEQGL-LKIRKELGLYANLRPCnfasdslLDLSPLKPEYAKGTDFVVVRE----LVGGIyfgERKEde 149
Cdd:PRK09222 73 ITTPQ-GGG----YKSLnVTLRKTLGLYANVRPC-------VSYHPFVETKHPNLDVVIIREneedLYAGI---EHRQ-- 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2855 150 GDGVAWDSEKYSVPEVQRITRMAAFLALQQNPPlPIWSLDKANVLASSRLWRKTVEETIKTEFPQLTVQHQLIDSAAMIL 229
Cdd:PRK09222 136 TPDVYQCLKLISRPGSEKIIRYAFEYARANGRK-KVTCLTKDNIMKLTDGLFHKVFDEIAKEYPDIEAEHYIVDIGAARL 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2855 230 VKSPTKLNgVVITNNMFGDIISDEASVIPGSLGLLPSASLAslpdtnKAFGLYEPCHGSAPDLpANK--VNPIATILSAA 307
Cdd:PRK09222 215 ATNPENFD-VIVTPNLYGDILSDIAAEISGSVGLAGSANIG------EEYAMFEAVHGSAPDI-AGKniANPSGLLNAAV 286
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 2855 308 MMLkLSLDLVEEGRALEEAVRNVLDAGVRTGDL-GGSNSTTEVG-DAIAKAV 357
Cdd:PRK09222 287 MML-VHIGQFDIAELIENAWLKTLEDGIHTADIyNEGVSKKKVGtKEFAEAV 337
|
|
| PLN00123 |
PLN00123 |
isocitrate dehydrogenase (NAD+) |
5-353 |
2.48e-22 |
|
isocitrate dehydrogenase (NAD+)
Pssm-ID: 215065 Cd Length: 360 Bit Score: 96.47 E-value: 2.48e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2855 5 IVVLPGDHVGKEVTDEAIKVLNAI-AEVrpeikfNFQHHLIGGAAIDatgtpLPDEALEASKKADAVLLGAVGGPKwGTG 83
Cdd:PLN00123 33 VTLIPGDGIGPLVTGAVEQVMEAMhAPV------YFERYEVHGDMKK-----VPEEVLESIRRNKVCLKGGLATPV-GGG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2855 84 AvrpeQGL-LKIRKELGLYANLRPCnfasdslLDLSPLKPEYaKGTDFVVVRELVGGIYFGERKEDEgDGVAWDSEKYSV 162
Cdd:PLN00123 101 V----SSLnVQLRKELDLFASLVNC-------FNLPGLPTRH-ENVDIVVIRENTEGEYSGLEHEVV-PGVVESLKVITK 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2855 163 PEVQRITRMA---AFLalqqNPPLPIWSLDKANVLA-SSRLWRKTVEEtIKTEFPQLTVQHQLIDSAAMILVKSPTKLNg 238
Cdd:PLN00123 168 FCSERIAKYAfeyAYL----NNRKKVTAVHKANIMKlADGLFLESCRE-VAKKYPGIKYNEIIVDNCCMQLVSKPEQFD- 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2855 239 VVITNNMFGDIISDEASVIPGSLGLLPSASLAslpDTNKAF--GLYEPCHGSAPDLPANKVNPIATILSAAMMLKlSLDL 316
Cdd:PLN00123 242 VMVTPNLYGNLVANTAAGIAGGTGVMPGGNVG---ADHAVFeqGASAGNVGNEKLVEQKKANPVALLLSSAMMLR-HLQF 317
|
330 340 350
....*....|....*....|....*....|....*...
gi 2855 317 VEEGRALEEAVRNVLDAG-VRTGDLGGSNSTTEVGDAI 353
Cdd:PLN00123 318 PSFADRLETAVKRVIAEGkYRTKDLGGSSTTQEVVDAV 355
|
|
| PRK06451 |
PRK06451 |
NADP-dependent isocitrate dehydrogenase; |
5-360 |
8.10e-20 |
|
NADP-dependent isocitrate dehydrogenase;
Pssm-ID: 235803 Cd Length: 412 Bit Score: 89.89 E-value: 8.10e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2855 5 IVVLPGDHVGKEVTDEAIKVLNAIAEV----RPEIKFnfQHHLIGGAAIDATGTPLPDEALEASKKADAVLLGAVGGP-- 78
Cdd:PRK06451 26 ILYVEGDGIGPEITHAAMKVINKAVEKaygsDREIKW--VEVLAGDKAEKLTGNRFPKESEELIEKYRVLLKGPLETPig 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2855 79 -KWGTGAVRpeqgllkIRKELGLYANLRPCNFASDslLDlSPLKpeYAKGTDFVVVRELVGGIYFG-------------- 143
Cdd:PRK06451 104 kGWKSINVA-------IRLMLDLYANIRPVKYIPG--IE-SPLK--NPEKIDLIIFRENTDDLYRGieypydseeakkir 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2855 144 ---------ERKEDEGDGVAWDSeKYsvpEVQRITRMAAFLALQQNPPlPIWSLDKANVLASSR-LWRKTVEETIKTEFP 213
Cdd:PRK06451 172 dflrkelgvEVEDDTGIGIKLIS-KF---KTQRIARMAIKYAIDHKRK-KVTIMHKGNVMKYTEgAFREWAYEVALKEFR 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2855 214 QLTVQHQLIDSAAMILVKSPTKLNGVVITNNMF-------------------GDIISDEASVIPGSLGLLPSASLAslpD 274
Cdd:PRK06451 247 DYVVTEEEVTKNYNGVPPSGKVIINDRIADNMFqqiiirpdeydiilapnvnGDYISDAAGALVGNIGMLGGANIG---D 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2855 275 TNkafGLYEPCHGSAPDLPA-NKVNPIATILSAAMMLKLsLDLVEEGRALEEAVRNVLDAGVRTGDLG-----GSNSTTE 348
Cdd:PRK06451 324 TG---GMFEAIHGTAPKYAGkNVANPTGIIKGGELMLRF-MGWDKAADLIDKAIMESIKQKKVTQDLArfmgvRALSTTE 399
|
410
....*....|..
gi 2855 349 VGDAIAKAVKEI 360
Cdd:PRK06451 400 YTDELISIIDML 411
|
|
| PRK07006 |
PRK07006 |
isocitrate dehydrogenase; Reviewed |
10-311 |
9.13e-12 |
|
isocitrate dehydrogenase; Reviewed
Pssm-ID: 180792 Cd Length: 409 Bit Score: 65.85 E-value: 9.13e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2855 10 GDHVGKEVTDEAIKVLNAIAE--VRPEIKFNFQHHLIGGAAIDATGTP--LPDEALEASKKadavLLGAVGGPkWGT--- 82
Cdd:PRK07006 27 GDGIGPDITPAMLKVVDAAVEkaYKGERKISWMEIYAGEKATKVYGEDvwLPEETLDLIRE----YRVAIKGP-LTTpvg 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2855 83 GAVRPEQglLKIRKELGLYANLRPCNFASDSLldlSPLK-PEyakGTDFVVVRELVGGIYfgerkedegDGVAWDSEKys 161
Cdd:PRK07006 102 GGIRSLN--VALRQELDLYVCLRPVRYFKGVP---SPVKrPE---DTDMVIFRENSEDIY---------AGIEWKAGS-- 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2855 162 vPEVQRITRmaaFLALQ---------QNPPLPIWSLDKAnvlASSRLWRKTVEETIKTEFPQLTVQH------------- 219
Cdd:PRK07006 163 -AEAKKVIK---FLQEEmgvkkirfpETSGIGIKPVSEE---GTERLVRAAIEYAIDNDRKSVTLVHkgnimkftegafk 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2855 220 -------------QLID-----------SAAMILVKS-------------PTKLNgVVITNNMFGDIISDEASVIPGSLG 262
Cdd:PRK07006 236 dwgyqlaeeefgdELIDggpwdkiknpeTGKEIIVKDsiadaflqqillrPAEYD-VIATMNLNGDYISDALAAQVGGIG 314
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 2855 263 LLPSASLaslpdtNKAFGLYEPCHGSAPDLPA-NKVNPIATILSAAMMLK 311
Cdd:PRK07006 315 IAPGANI------NDGHAIFEATHGTAPKYAGlDKVNPGSVILSAEMMLR 358
|
|
| PRK07362 |
PRK07362 |
NADP-dependent isocitrate dehydrogenase; |
239-329 |
2.71e-07 |
|
NADP-dependent isocitrate dehydrogenase;
Pssm-ID: 180944 Cd Length: 474 Bit Score: 52.02 E-value: 2.71e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2855 239 VVITNNMFGDIISDEASVIPGSLGLLPSASLAslpDTNKAFglyEPCHGSAPDLPA-NKVNPIATILSAAMMLKL----- 312
Cdd:PRK07362 355 ILATLNLNGDYISDAAAAIVGGLGMAPGANIG---DNAAIF---EATHGTAPKHAGlDRINPGSVILSGVMMLEYlgwqe 428
|
90
....*....|....*..
gi 2855 313 SLDLVEEGraLEEAVRN 329
Cdd:PRK07362 429 AADLITKG--LSAAIAN 443
|
|
| PLN03065 |
PLN03065 |
isocitrate dehydrogenase (NADP+); Provisional |
149-359 |
1.47e-03 |
|
isocitrate dehydrogenase (NADP+); Provisional
Pssm-ID: 178617 [Multi-domain] Cd Length: 483 Bit Score: 40.25 E-value: 1.47e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2855 149 EGDGVAWdsEKYSVPEVQRITRMAAF-LALQQNPPLPIWSldKANVLAS-----SRLWRKTVEETIKTEFPQLTV--QHQ 220
Cdd:PLN03065 243 KGPGVAL--AMYNVDESIRAFAESSMaMALQKKWPLYLST--KNTILKKydgrfKDIFQEVYEEQWKQKFEEHSIwyEHR 318
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2855 221 LIDSAAMILVKSptklNG--VVITNNMFGDIISDEASVIPGSLGLLPSASLASLPDTNKAfglyEPCHGSA--------P 290
Cdd:PLN03065 319 LIDDMVAYAVKS----EGgyVWACKNYDGDVQSDLLAQGFGSLGLMTSVLLSSDGKTLEA----EAAHGTVtrhfrlhqK 390
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2855 291 DLPANkVNPIATILSAAMML--KLSLD----LVEEGRALEEAVRNVLDAGVRTGDLG----GSN-------STTEVGDAI 353
Cdd:PLN03065 391 GQETS-TNSIASIFAWTRGLehRAKLDkneeLLDFVHKLESACIETVESGKMTKDLAilihGPKvsrefylNTEEFIDAV 469
|
....*.
gi 2855 354 AKAVKE 359
Cdd:PLN03065 470 AQTLAT 475
|
|
| |
