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Conserved domains on  [gi|483474|emb|CAA55699|]
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90K [Homo sapiens]

Protein Classification

galectin-3-binding protein( domain architecture ID 13894815)

galectin-3-binding protein (Lgals3bp) promotes integrin-mediated cell adhesion. May stimulate host defense against viruses and tumor cells; galectin-3-binding protein promotes integrin-mediated cell adhesion

Gene Ontology:  GO:0006968|GO:0007155

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BTB_POZ_M2BP cd18304
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 136-247 3.93e-58

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Mac-2-binding protein (MAC2BP/M2BP); M2BP is also called galectin-3-binding protein, basement membrane autoantigen p105, lectin galactoside-binding soluble 3-binding protein (LGALS3BP), or tumor-associated antigen 90K. It promotes integrin-mediated cell adhesion and may stimulate host defense against viruses and tumor cells. It contains a scavenger receptor cysteine-rich domain, followed by BTB and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


:

Pssm-ID: 349613 [Multi-domain]  Cd Length: 114  Bit Score: 190.00  E-value: 3.93e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 483474   136 SRELSEALGQIFDSQRGCDLSISVNVQG--EDALGFCGHTVILTANLEAQALWKEPGSNVTMSVDAECVPMVRDLLRYFY 213
Cdd:cd18304   1 SMELSEDLGLLYDSQQGCDFNISVLTAGgeEEELTFCAHRVILMLSPEANFLHKTGSSNITLDVDEECLPHVPDFLRYFY 80

                        90       100       110
                ....*....|....*....|....*....|....
gi 483474   214 SRRIDITLSSVKCFHKLASAYGARQLQGYCASLF 247
Cdd:cd18304  81 TRQIDITLTSVKCFHKLASIYGVRKLREYCGQLF 114
SR smart00202
Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR ...
 24-124 6.18e-49

Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR domains that contain 6 conserved cysteines. May bind bacterial antigens in the protein MARCO.


:

Pssm-ID: 214555 [Multi-domain]  Cd Length: 101  Bit Score: 165.21  E-value: 6.18e-49
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 483474       24 MRLADGGATNQGRVEIFYRGQWGTVCDNLWDLTDASVVCRALGFENATQALGRAAFGQGSGPIMLDEVQCTGTEASLADC 103
Cdd:smart00202   1 VRLVGGGSPCEGRVEVYHNGQWGTVCDDGWDLRDANVVCRQLGFGGAVSASGSAYFGPGSGPIWLDNVRCSGTEASLSDC 80

                           90       100
                   ....*....|....*....|.
gi 483474      104 KSLGWLKSNCRHERDAGVVCT 124
Cdd:smart00202  81 PHSGWGSHNCSHGEDAGVVCS 101
BACK_LGALS3BP cd18496
BACK (BTB and C-terminal Kelch) domain found in lectin galactoside-binding soluble 3-binding ...
 256-329 1.12e-33

BACK (BTB and C-terminal Kelch) domain found in lectin galactoside-binding soluble 3-binding protein (LGALS3BP); LGALS3BP, also called galectin-3-binding protein, or basement membrane autoantigen p105, or Mac-2-binding protein (MAC2BP/M2BP), or tumor-associated antigen 90K, promotes integrin-mediated cell adhesion. It may stimulate host defense against viruses and tumor cells.


:

Pssm-ID: 350571  Cd Length: 74  Bit Score: 122.51  E-value: 1.12e-33
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 483474   256 SFQMPLDLYAYAVATGDALLEKLCLQFLAWNFEALTQAEAWPSVPTDLLQLLLPRSDLAVPSELALLKAVDTWS 329
Cdd:cd18496   1 SFQTQLSLYEYALSTGDALLRGLCLQYLAWNCEALISSEAWLDLPWDQLKALLTRSDLVVPDELVLLKALEAWA 74
 
Name Accession Description Interval E-value
BTB_POZ_M2BP cd18304
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 136-247 3.93e-58

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Mac-2-binding protein (MAC2BP/M2BP); M2BP is also called galectin-3-binding protein, basement membrane autoantigen p105, lectin galactoside-binding soluble 3-binding protein (LGALS3BP), or tumor-associated antigen 90K. It promotes integrin-mediated cell adhesion and may stimulate host defense against viruses and tumor cells. It contains a scavenger receptor cysteine-rich domain, followed by BTB and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349613 [Multi-domain]  Cd Length: 114  Bit Score: 190.00  E-value: 3.93e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 483474   136 SRELSEALGQIFDSQRGCDLSISVNVQG--EDALGFCGHTVILTANLEAQALWKEPGSNVTMSVDAECVPMVRDLLRYFY 213
Cdd:cd18304   1 SMELSEDLGLLYDSQQGCDFNISVLTAGgeEEELTFCAHRVILMLSPEANFLHKTGSSNITLDVDEECLPHVPDFLRYFY 80

                        90       100       110
                ....*....|....*....|....*....|....
gi 483474   214 SRRIDITLSSVKCFHKLASAYGARQLQGYCASLF 247
Cdd:cd18304  81 TRQIDITLTSVKCFHKLASIYGVRKLREYCGQLF 114
SR smart00202
Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR ...
 24-124 6.18e-49

Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR domains that contain 6 conserved cysteines. May bind bacterial antigens in the protein MARCO.


Pssm-ID: 214555 [Multi-domain]  Cd Length: 101  Bit Score: 165.21  E-value: 6.18e-49
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 483474       24 MRLADGGATNQGRVEIFYRGQWGTVCDNLWDLTDASVVCRALGFENATQALGRAAFGQGSGPIMLDEVQCTGTEASLADC 103
Cdd:smart00202   1 VRLVGGGSPCEGRVEVYHNGQWGTVCDDGWDLRDANVVCRQLGFGGAVSASGSAYFGPGSGPIWLDNVRCSGTEASLSDC 80

                           90       100
                   ....*....|....*....|.
gi 483474      104 KSLGWLKSNCRHERDAGVVCT 124
Cdd:smart00202  81 PHSGWGSHNCSHGEDAGVVCS 101
SRCR pfam00530
Scavenger receptor cysteine-rich domain; These domains are disulphide rich extracellular ...
 29-124 3.36e-40

Scavenger receptor cysteine-rich domain; These domains are disulphide rich extracellular domains. These domains are found in several extracellular receptors and may be involved in protein-protein interactions.


Pssm-ID: 459844  Cd Length: 98  Bit Score: 141.36  E-value: 3.36e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 483474      29 GGATNQGRVEIFYRGQWGTVCDNLWDLTDASVVCRALGFENATQAL-GRAAFGQG-SGPIMLDEVQCTGTEASLADCKSL 106
Cdd:pfam00530   1 GSSPCEGRVEVYHNGSWGTVCDDGWDLRDAHVVCRQLGCGGAVSAPsGCSYFGPGsTGPIWLDDVRCSGNETSLWQCPHR 80

                          90
                  ....*....|....*...
gi 483474     107 GWLKSNCRHERDAGVVCT 124
Cdd:pfam00530  81 PWGNHNCSHSEDAGVICS 98
BACK_LGALS3BP cd18496
BACK (BTB and C-terminal Kelch) domain found in lectin galactoside-binding soluble 3-binding ...
 256-329 1.12e-33

BACK (BTB and C-terminal Kelch) domain found in lectin galactoside-binding soluble 3-binding protein (LGALS3BP); LGALS3BP, also called galectin-3-binding protein, or basement membrane autoantigen p105, or Mac-2-binding protein (MAC2BP/M2BP), or tumor-associated antigen 90K, promotes integrin-mediated cell adhesion. It may stimulate host defense against viruses and tumor cells.


Pssm-ID: 350571  Cd Length: 74  Bit Score: 122.51  E-value: 1.12e-33
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 483474   256 SFQMPLDLYAYAVATGDALLEKLCLQFLAWNFEALTQAEAWPSVPTDLLQLLLPRSDLAVPSELALLKAVDTWS 329
Cdd:cd18496   1 SFQTQLSLYEYALSTGDALLRGLCLQYLAWNCEALISSEAWLDLPWDQLKALLTRSDLVVPDELVLLKALEAWA 74
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 261-358 2.60e-18

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 80.46  E-value: 2.60e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 483474      261 LDLYAYAVATGDALLEKLCLQFLAWNFEALTQAEAWPSVPTDLLQLLLPRSDLAVPSELALLKAVDTWSWGERASH-EEV 339
Cdd:smart00875   2 LGIRRFADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNVSSEEEVFEAVLRWVKHDPEKRrEHL 81

                           90
                   ....*....|....*....
gi 483474      340 EGLVEKIRFPMMLPEELFE 358
Cdd:smart00875  82 PELLEHVRLPLLSPDYLLE 100
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
 261-359 1.13e-11

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 61.41  E-value: 1.13e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 483474     261 LDLYAYAVATGDALLEKLCLQFLAWNFEALTQAEAWPSVPTDLLQLLLPRSDLAVPSELALLKAVDTW---SWGERASHe 337
Cdd:pfam07707   2 LGIYRFADAYGCTELAEAALRFILQNFLEVAKSEEFLELSLEQLLELLSSDDLNVPSEEEVFEAVIRWvkhDVERRKKH- 80

                          90       100
                  ....*....|....*....|..
gi 483474     338 eVEGLVEKIRFPMMLPEELFEL 359
Cdd:pfam07707  81 -LPELLSAVRLPLLSPQYLLNL 101
 
Name Accession Description Interval E-value
BTB_POZ_M2BP cd18304
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 136-247 3.93e-58

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Mac-2-binding protein (MAC2BP/M2BP); M2BP is also called galectin-3-binding protein, basement membrane autoantigen p105, lectin galactoside-binding soluble 3-binding protein (LGALS3BP), or tumor-associated antigen 90K. It promotes integrin-mediated cell adhesion and may stimulate host defense against viruses and tumor cells. It contains a scavenger receptor cysteine-rich domain, followed by BTB and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349613 [Multi-domain]  Cd Length: 114  Bit Score: 190.00  E-value: 3.93e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 483474   136 SRELSEALGQIFDSQRGCDLSISVNVQG--EDALGFCGHTVILTANLEAQALWKEPGSNVTMSVDAECVPMVRDLLRYFY 213
Cdd:cd18304   1 SMELSEDLGLLYDSQQGCDFNISVLTAGgeEEELTFCAHRVILMLSPEANFLHKTGSSNITLDVDEECLPHVPDFLRYFY 80

                        90       100       110
                ....*....|....*....|....*....|....
gi 483474   214 SRRIDITLSSVKCFHKLASAYGARQLQGYCASLF 247
Cdd:cd18304  81 TRQIDITLTSVKCFHKLASIYGVRKLREYCGQLF 114
SR smart00202
Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR ...
 24-124 6.18e-49

Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR domains that contain 6 conserved cysteines. May bind bacterial antigens in the protein MARCO.


Pssm-ID: 214555 [Multi-domain]  Cd Length: 101  Bit Score: 165.21  E-value: 6.18e-49
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 483474       24 MRLADGGATNQGRVEIFYRGQWGTVCDNLWDLTDASVVCRALGFENATQALGRAAFGQGSGPIMLDEVQCTGTEASLADC 103
Cdd:smart00202   1 VRLVGGGSPCEGRVEVYHNGQWGTVCDDGWDLRDANVVCRQLGFGGAVSASGSAYFGPGSGPIWLDNVRCSGTEASLSDC 80

                           90       100
                   ....*....|....*....|.
gi 483474      104 KSLGWLKSNCRHERDAGVVCT 124
Cdd:smart00202  81 PHSGWGSHNCSHGEDAGVVCS 101
SRCR pfam00530
Scavenger receptor cysteine-rich domain; These domains are disulphide rich extracellular ...
 29-124 3.36e-40

Scavenger receptor cysteine-rich domain; These domains are disulphide rich extracellular domains. These domains are found in several extracellular receptors and may be involved in protein-protein interactions.


Pssm-ID: 459844  Cd Length: 98  Bit Score: 141.36  E-value: 3.36e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 483474      29 GGATNQGRVEIFYRGQWGTVCDNLWDLTDASVVCRALGFENATQAL-GRAAFGQG-SGPIMLDEVQCTGTEASLADCKSL 106
Cdd:pfam00530   1 GSSPCEGRVEVYHNGSWGTVCDDGWDLRDAHVVCRQLGCGGAVSAPsGCSYFGPGsTGPIWLDDVRCSGNETSLWQCPHR 80

                          90
                  ....*....|....*...
gi 483474     107 GWLKSNCRHERDAGVVCT 124
Cdd:pfam00530  81 PWGNHNCSHSEDAGVICS 98
BACK_LGALS3BP cd18496
BACK (BTB and C-terminal Kelch) domain found in lectin galactoside-binding soluble 3-binding ...
 256-329 1.12e-33

BACK (BTB and C-terminal Kelch) domain found in lectin galactoside-binding soluble 3-binding protein (LGALS3BP); LGALS3BP, also called galectin-3-binding protein, or basement membrane autoantigen p105, or Mac-2-binding protein (MAC2BP/M2BP), or tumor-associated antigen 90K, promotes integrin-mediated cell adhesion. It may stimulate host defense against viruses and tumor cells.


Pssm-ID: 350571  Cd Length: 74  Bit Score: 122.51  E-value: 1.12e-33
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 483474   256 SFQMPLDLYAYAVATGDALLEKLCLQFLAWNFEALTQAEAWPSVPTDLLQLLLPRSDLAVPSELALLKAVDTWS 329
Cdd:cd18496   1 SFQTQLSLYEYALSTGDALLRGLCLQYLAWNCEALISSEAWLDLPWDQLKALLTRSDLVVPDELVLLKALEAWA 74
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 261-358 2.60e-18

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 80.46  E-value: 2.60e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 483474      261 LDLYAYAVATGDALLEKLCLQFLAWNFEALTQAEAWPSVPTDLLQLLLPRSDLAVPSELALLKAVDTWSWGERASH-EEV 339
Cdd:smart00875   2 LGIRRFADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNVSSEEEVFEAVLRWVKHDPEKRrEHL 81

                           90
                   ....*....|....*....
gi 483474      340 EGLVEKIRFPMMLPEELFE 358
Cdd:smart00875  82 PELLEHVRLPLLSPDYLLE 100
BACK_BTBD17 cd18493
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 17 (BTBD17); ...
 264-328 7.60e-16

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also termed galectin-3-binding protein-like, is a BTB-domain-containing Kelch-like protein. Its function remains unclear. It may be involved in hepatocellular carcinoma development and progression.


Pssm-ID: 350568  Cd Length: 74  Bit Score: 72.23  E-value: 7.60e-16
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 483474   264 YAYAVATGDALLEKLCLQFLAWNFEALTQAEAWPSVPTDLLQLLLPRSDLAVPSELALLKAVDTW 328
Cdd:cd18493   9 LQYAKMCGHKELAEACLEFIAWNFEKVLKSPDWLNLDLDLLVSLLQSSDLVVEDEYTLFQAVEKW 73
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
 261-359 1.13e-11

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 61.41  E-value: 1.13e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 483474     261 LDLYAYAVATGDALLEKLCLQFLAWNFEALTQAEAWPSVPTDLLQLLLPRSDLAVPSELALLKAVDTW---SWGERASHe 337
Cdd:pfam07707   2 LGIYRFADAYGCTELAEAALRFILQNFLEVAKSEEFLELSLEQLLELLSSDDLNVPSEEEVFEAVIRWvkhDVERRKKH- 80

                          90       100
                  ....*....|....*....|..
gi 483474     338 eVEGLVEKIRFPMMLPEELFEL 359
Cdd:pfam07707  81 -LPELLSAVRLPLLSPQYLLNL 101
BTB_POZ_BTBD17 cd18292
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 136-245 1.27e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349601 [Multi-domain]  Cd Length: 114  Bit Score: 50.36  E-value: 1.27e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 483474   136 SRELSEALGQIFDSQRGCDLSISVNVQGedalgFCGHTVILTA------NLEAQALWKEPGSN-VTMSVDAECVPMVRDL 208
Cdd:cd18292   1 SREFLQDIAQLYNNEELSDIVLRVGGKV-----FHAHRLILAKssdvfrVMLSNDWWSESKQSeIELVEDPECAAVFEKF 75

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 483474   209 LRYFYSRRIDITLSSVKCFHKLASAYGARQLQGYCAS 245
Cdd:cd18292  76 LRYLYTGQISVNLETALPLLMLADKYNVTDLKQLCVD 112
BACK_KBTBD3 cd18480
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 261-328 4.60e-06

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also termed BTB and kelch domain-containing protein 3 (BKLHD3), is a BTB-Kelch family protein. Its function remains unclear.


Pssm-ID: 350555 [Multi-domain]  Cd Length: 82  Bit Score: 45.01  E-value: 4.60e-06
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 483474   261 LDLYAYAVATGDALLEKLCLQFLAWNFEALTQAEAWPSVPTDLLQLLLPRSDLAVPSELALLKAVDTW 328
Cdd:cd18480   7 LQLLSFAESYGSTRLLDHALEFVMQHFSLLSQSQEFLELNFEVLEKILEADELNVPDEEAVLKAVLRW 74
BACK cd14733
BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal ...
 261-308 5.56e-04

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal to a BTB domain, in a diverse set of architectures together with Kelch, MATH, and/or TAZ domains. It is involved in interactions with the Cullin3 (Cul3) ubiquitin ligase complex, as well as in homo-oligomerization. Most proteins containing the BACK domain are understood to function as adaptor proteins that play a role in ubiquitination of various substrates.


Pssm-ID: 350515 [Multi-domain]  Cd Length: 55  Bit Score: 38.03  E-value: 5.56e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*...
gi 483474   261 LDLYAYAVATGDALLEKLCLQFLAWNFEALTQAEAWPSVPTDLLQLLL 308
Cdd:cd14733   6 LGILELADLYNLEELKEKALKFILENFEEVSKSEEFLELSVELLLELL 53
BACK_KLHL9_13 cd18449
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL9 and KLHL13; KLHL9 ...
 282-349 1.64e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL9 and KLHL13; KLHL9 and KLHL13 (also termed BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis.


Pssm-ID: 350524 [Multi-domain]  Cd Length: 95  Bit Score: 38.17  E-value: 1.64e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 483474   282 FLAWNFEALTQAEAWPSVPTDLLQLLLPRSDLAVPSELALLKAVDTWSWGERASHEEVEGLVEKIRFP 349
Cdd:cd18449  28 FILKNFPALLSTGDFVKLPFERLAFVLSSNSLKGCTELELFKAACRWLRHEDDRMQFAAKLMENIRFP 95
BTB_POZ_ZBTB_KLHL-like cd18186
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 153-234 5.85e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349497 [Multi-domain]  Cd Length: 82  Bit Score: 35.99  E-value: 5.85e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 483474   153 CDLSIsvNVQGEDalgFCGHTVILTAN---LEA--QALWKEPGSN-VTMS-VDAECVpmvRDLLRYFYSRRIDITLSSVK 225
Cdd:cd18186   2 CDVTL--VVGGRE---FPAHRAVLAARspyFRAmfSSGMKESSSSeIELDdVSPEAF---EALLDYIYTGELELSEENVE 73


                ....*....
gi 483474   226 CFHKLASAY 234
Cdd:cd18186  74 ELLAAADKL 82
BACK_KLHL35 cd18474
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 35 (KLHL35); KLHL35 belongs ...
 261-328 8.42e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 35 (KLHL35); KLHL35 belongs to the KLHL family. Its function remains unclear. Hypermethylation of KLHL35 is associated with hepatocellular carcinoma and abdominal aortic aneurysm.


Pssm-ID: 350549 [Multi-domain]  Cd Length: 79  Bit Score: 35.56  E-value: 8.42e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 483474   261 LDLYAYAVATGDALLEKLCLQFLAWNFEALTQAEAWPSVPTDLLQLLLPRSDLAVPSELALLKAVDTW 328
Cdd:cd18474   7 LALLAAADALHCAPLQEHCIRVLLRDFAQAARHPSFLKLELQLVLELLADDSLAVRSEEVVLEAALRW 74
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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