NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|673442|emb|CAA58013|]
View 

Ig Vheavy-PCG-4, partial [Mus musculus]

Protein Classification

immunoglobulin heavy chain variable domain-containing protein( domain architecture ID 10141748)

immunoglobulin heavy chain variable domain-containing protein similar to immunoglobulin heavy chains

CATH:  2.60.40.10
Gene Ontology:  GO:0003823
PubMed:  9571064|9541533
SCOP:  3000071

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
IgV_H cd04981
Immunoglobulin (Ig) heavy chain (H), variable (V) domain; The members here are composed of the ...
 22-140 6.24e-61

Immunoglobulin (Ig) heavy chain (H), variable (V) domain; The members here are composed of the immunoglobulin (Ig) heavy chain (H), variable (V) domain. This group contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. There are five types of heavy chains (alpha, gamma, delta, epsilon, and mu), which determines the type of immunoglobulin formed: IgA, IgG, IgD, IgE, and IgM, respectively. In higher vertebrates, there are two types of light chain, designated kappa and lambda, which can associate with any of the heavy chains. This family includes alpha, gamma, delta, epsilon, and mu heavy chains.


:

Pssm-ID: 409370 [Multi-domain]  Cd Length: 118  Bit Score: 183.28  E-value: 6.24e-61
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 673442    22 QLKESGPGLVAPSQSLSITCTVSGFSLTSYGVHWVRQPPGKGLEGLGVIW-AGGSTNYNSALMSRLSISKDNSKSQVFLK 100
Cdd:cd04981   1 QLQESGPGLVKPGQSLKLSCKASGFTFTSYGMGWVRQAPGKGLEWIGLIYpGGGDTYYADSFKGRFTITRDTSKSTAYLQ 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 673442   101 MNSLQIDDTAMYYCARSPTSTMDtpYAMDYWGQGTSVTVS 140
Cdd:cd04981  81 LNSLTSEDTAVYYCARGLGGYGY--SYFDYWGQGTTVTVS 118
 
Name Accession Description Interval E-value
IgV_H cd04981
Immunoglobulin (Ig) heavy chain (H), variable (V) domain; The members here are composed of the ...
 22-140 6.24e-61

Immunoglobulin (Ig) heavy chain (H), variable (V) domain; The members here are composed of the immunoglobulin (Ig) heavy chain (H), variable (V) domain. This group contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. There are five types of heavy chains (alpha, gamma, delta, epsilon, and mu), which determines the type of immunoglobulin formed: IgA, IgG, IgD, IgE, and IgM, respectively. In higher vertebrates, there are two types of light chain, designated kappa and lambda, which can associate with any of the heavy chains. This family includes alpha, gamma, delta, epsilon, and mu heavy chains.


Pssm-ID: 409370 [Multi-domain]  Cd Length: 118  Bit Score: 183.28  E-value: 6.24e-61
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 673442    22 QLKESGPGLVAPSQSLSITCTVSGFSLTSYGVHWVRQPPGKGLEGLGVIW-AGGSTNYNSALMSRLSISKDNSKSQVFLK 100
Cdd:cd04981   1 QLQESGPGLVKPGQSLKLSCKASGFTFTSYGMGWVRQAPGKGLEWIGLIYpGGGDTYYADSFKGRFTITRDTSKSTAYLQ 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 673442   101 MNSLQIDDTAMYYCARSPTSTMDtpYAMDYWGQGTSVTVS 140
Cdd:cd04981  81 LNSLTSEDTAVYYCARGLGGYGY--SYFDYWGQGTTVTVS 118
IGv smart00406
Immunoglobulin V-Type;
36-116 2.58e-32

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 109.39  E-value: 2.58e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 673442       36 SLSITCTVSGFSLTSYGVHWVRQPPGKGLEGLGVIWAGGSTNYNSALMSRLSISKDNSKSQVFLKMNSLQIDDTAMYYCA 115
Cdd:smart00406   1 SVTLSCKFSGSTFSSYYVSWVRQPPGKGLEWLGYIGSNGSSYYQESYKGRFTISKDTSKNDVSLTISNLRVEDTGTYYCA 80


                   .
gi 673442      116 R 116
Cdd:smart00406  81 V 81
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 30-139 2.04e-11

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 56.70  E-value: 2.04e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 673442      30 LVAPSQSLSITCTVSGF-SLTSYGVHWVRQPPGKGLEGLGVIWAGGSTnyNSALMSRLSISKDNSKSQVFLKMNSLQIDD 108
Cdd:pfam07686   7 TVALGGSVTLPCTYSSSmSEASTSVYWYRQPPGKGPTFLIAYYSNGSE--EGVKKGRFSGRGDPSNGDGSLTIQNLTLSD 84

                          90       100       110
                  ....*....|....*....|....*....|.
gi 673442     109 TAMYYCARSPTSTMdtpyamdYWGQGTSVTV 139
Cdd:pfam07686  85 SGTYTCAVIPSGEG-------VFGKGTRLTV 108
 
Name Accession Description Interval E-value
IgV_H cd04981
Immunoglobulin (Ig) heavy chain (H), variable (V) domain; The members here are composed of the ...
 22-140 6.24e-61

Immunoglobulin (Ig) heavy chain (H), variable (V) domain; The members here are composed of the immunoglobulin (Ig) heavy chain (H), variable (V) domain. This group contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. There are five types of heavy chains (alpha, gamma, delta, epsilon, and mu), which determines the type of immunoglobulin formed: IgA, IgG, IgD, IgE, and IgM, respectively. In higher vertebrates, there are two types of light chain, designated kappa and lambda, which can associate with any of the heavy chains. This family includes alpha, gamma, delta, epsilon, and mu heavy chains.


Pssm-ID: 409370 [Multi-domain]  Cd Length: 118  Bit Score: 183.28  E-value: 6.24e-61
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 673442    22 QLKESGPGLVAPSQSLSITCTVSGFSLTSYGVHWVRQPPGKGLEGLGVIW-AGGSTNYNSALMSRLSISKDNSKSQVFLK 100
Cdd:cd04981   1 QLQESGPGLVKPGQSLKLSCKASGFTFTSYGMGWVRQAPGKGLEWIGLIYpGGGDTYYADSFKGRFTITRDTSKSTAYLQ 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 673442   101 MNSLQIDDTAMYYCARSPTSTMDtpYAMDYWGQGTSVTVS 140
Cdd:cd04981  81 LNSLTSEDTAVYYCARGLGGYGY--SYFDYWGQGTTVTVS 118
IGv smart00406
Immunoglobulin V-Type;
36-116 2.58e-32

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 109.39  E-value: 2.58e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 673442       36 SLSITCTVSGFSLTSYGVHWVRQPPGKGLEGLGVIWAGGSTNYNSALMSRLSISKDNSKSQVFLKMNSLQIDDTAMYYCA 115
Cdd:smart00406   1 SVTLSCKFSGSTFSSYYVSWVRQPPGKGLEWLGYIGSNGSSYYQESYKGRFTISKDTSKNDVSLTISNLRVEDTGTYYCA 80


                   .
gi 673442      116 R 116
Cdd:smart00406  81 V 81
IgV cd00099
Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin ...
 30-139 1.02e-20

Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin variable domain (IgV). The IgV family contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology, and are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E and, D strands in one sheet and A', G, F, C, C', and C" strands in the other.


Pssm-ID: 409355 [Multi-domain]  Cd Length: 111  Bit Score: 80.84  E-value: 1.02e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 673442    30 LVAPSQSLSITCTVSGfSLTSYGVHWVRQPPGKGLEGLgVIWAGGSTNYNSALMSRLSISKDnSKSQVFLKMNSLQIDDT 109
Cdd:cd00099   9 SVQEGESVTLSCEVSS-SFSSTYIYWYRQKPGQGPEFL-IYLSSSKGKTKGGVPGRFSGSRD-GTSSFSLTISNLQPEDS 85

                        90       100       110
                ....*....|....*....|....*....|
gi 673442   110 AMYYCARSPTSTMDTpyamDYWGQGTSVTV 139
Cdd:cd00099  86 GTYYCAVSESGGTDK----LTFGSGTRLTV 111
IgV_TCR_gamma cd04982
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) gamma chain; The members here ...
 32-116 5.93e-15

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) gamma chain; The members here are composed of the immunoglobulin (Ig) variable (V) domain of the gamma chain of gamma/delta T-cell receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are heterodimers consisting of alpha and beta chains or gamma and delta chains. Each chain contains a variable (V) and a constant (C) region. The majority of T cells contain alpha/beta TCRs, but a small subset contain gamma/delta TCRs. Alpha/beta TCRs recognize antigens as peptide fragments presented by major histocompatibility complex (MHC) molecules. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Gamma/delta T cells can also be stimulated by non-peptide antigens such as small phosphate- or amine-containing compounds. The variable domain of gamma/delta TCRs is responsible for antigen recognition and is located at the N-terminus of the receptor. Members of this group contain the standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409371  Cd Length: 117  Bit Score: 66.23  E-value: 5.93e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 673442    32 APSQSLSITCTVSGFSLTSYGVHWVRQPPGKGLEGLGVIWAGGSTNYNSALMS-RLSISKDNSKSQVFLKMNSLQIDDTA 110
Cdd:cd04982  11 EESKSVTISCKVSGIDFSTTYIHWYRQKPGQALERLLYVSSTSAVRKDSGKTKnKFEARKDVGKSTSTLTITNLEKEDSA 90


                ....*.
gi 673442   111 MYYCAR 116
Cdd:cd04982  91 TYYCAY 96
IgV_TCR_alpha cd04983
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) alpha chain and similar ...
 33-139 1.89e-12

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) alpha chain and similar proteins; The members here are composed of the immunoglobulin (Ig) variable domain of the alpha chain of alpha/beta T-cell antigen receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are composed of alpha and beta, or gamma and delta polypeptide chains with variable (V) and constant (C) regions. This group represents the variable domain of the alpha chain of TCRs and also includes the variable domain of delta chains of TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. The variable domain of TCRs is responsible for antigen recognition, and is located at the N-terminus of the receptor. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409372 [Multi-domain]  Cd Length: 109  Bit Score: 59.59  E-value: 1.89e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 673442    33 PSQSLSIT--------CTVSgfSLTSYGVHWVRQPPGKGLEGLGVIwAGGSTNYNSAlmsRLSISKDNSKSQVFLKMNSL 104
Cdd:cd04983   4 SPQSLSVQegenvtlnCNYS--TSTFYYLFWYRQYPGQGPQFLIYI-SSDSGNKKKG---RFSATLDKSRKSSSLHISAA 77

                        90       100       110
                ....*....|....*....|....*....|....*
gi 673442   105 QIDDTAMYYCARSPTSTMDTPyamdYWGQGTSVTV 139
Cdd:cd04983  78 QLSDSAVYFCALSESGGTGKL----TFGKGTRLTV 108
IgV_H_TCR_mu cd16095
T-cell receptor Mu, Heavy chain, variable (V) domain; The members here are composed of the ...
 20-139 5.38e-12

T-cell receptor Mu, Heavy chain, variable (V) domain; The members here are composed of the immunoglobulin (Ig) heavy chain (H), variable (V) domain of the T-cell receptor Mu. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. There are five types of heavy chains (alpha, gamma, delta, epsilon, and mu), which determines the type of immunoglobulin formed: IgA, IgG, IgD, IgE, and IgM, respectively. In higher vertebrates, there are two types of light chain, designated kappa and lambda, which can associate with any of the heavy chains. This family includes alpha, gamma, delta, epsilon, and mu heavy chains. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409514  Cd Length: 115  Bit Score: 58.73  E-value: 5.38e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 673442    20 QVQLKESGPGLVAPSQSLSITCTVSGFSLTSYGVHWVRQPPGKGLEGLGviwaggSTNYNSALMS--RLSISKDNSKSQV 97
Cdd:cd16095   1 ETQLEESGGGSHPAGKTLSLKCQTSGFQFNTSQLSWYLWVPGHAPLWLT------SLDHISTKVSedRITSSREDTNSQI 74

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 673442    98 FLKMNSLQIDDTAMYYCARSPTSTMDTPYAMdyWGQGTSVTV 139
Cdd:cd16095  75 FLQIKGLGLRDSGQYHCARRVGYGDDTDKLI--FGPGTDVIV 114
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 30-139 2.04e-11

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 56.70  E-value: 2.04e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 673442      30 LVAPSQSLSITCTVSGF-SLTSYGVHWVRQPPGKGLEGLGVIWAGGSTnyNSALMSRLSISKDNSKSQVFLKMNSLQIDD 108
Cdd:pfam07686   7 TVALGGSVTLPCTYSSSmSEASTSVYWYRQPPGKGPTFLIAYYSNGSE--EGVKKGRFSGRGDPSNGDGSLTIQNLTLSD 84

                          90       100       110
                  ....*....|....*....|....*....|.
gi 673442     109 TAMYYCARSPTSTMdtpyamdYWGQGTSVTV 139
Cdd:pfam07686  85 SGTYTCAVIPSGEG-------VFGKGTRLTV 108
IgV_L_lambda cd04984
Immunoglobulin (Ig) lambda light chain variable (V) domain; The members here are composed of ...
 31-139 5.51e-11

Immunoglobulin (Ig) lambda light chain variable (V) domain; The members here are composed of the immunoglobulin (Ig) light chain, lambda type, variable (V) domain. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. There are two types of light chains: kappa and lambda, each composed of a constant domain (CL) and a variable domain (VL). There are five types of heavy chains (alpha, gamma, delta, epsilon, and mu), which determines the type of immunoglobulin formed: IgA, IgG, IgD, IgE, and IgM, respectively. In higher vertebrates, there are two types of light chain, designated kappa and lambda, which seem to be functionally identical, and can associate with any of the heavy chains. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409373  Cd Length: 105  Bit Score: 55.55  E-value: 5.51e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 673442    31 VAPSQSLSITCTVSGFSLTSYGVHWVRQPPGKGLEGLgviwAGGSTNYNSALMSRLSISKDNSKSqvFLKMNSLQIDDTA 110
Cdd:cd04984  10 VSPGETVTITCTGSSGNISGNYVNWYQQKPGSAPRYL----IYEDKHRPSGIPDRFSGSKSGNTA--SLTISGAQTEDEA 83

                        90       100       110
                ....*....|....*....|....*....|
gi 673442   111 MYYCArsptstmdTPYAMDY-WGQGTSVTV 139
Cdd:cd04984  84 DYYCQ--------VWDSNSYvFGGGTKLTV 105
IgV_TCR_beta cd05899
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) beta chain; The members here ...
 55-139 1.39e-10

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) beta chain; The members here are composed of the immunoglobulin (Ig) variable domain of the beta chain of alpha/beta T-cell antigen receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are composed of alpha and beta, or gamma and delta, polypeptide chains with variable (V) and constant (C) regions. This group includes the variable domain of the alpha chain of alpha/beta TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. The variable domain of TCRs is responsible for antigen recognition, and is located at the N-terminus of the receptor. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409480  Cd Length: 110  Bit Score: 54.60  E-value: 1.39e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 673442    55 WVRQPPGKGLEGLGVIWAGGSTNYNSALMSRLSISKdNSKSQVFLKMNSLQIDDTAMYYCARSPTSTMDTPyamdYWGQG 134
Cdd:cd05899  31 WYRQDPGKGLQLLFYSYGGGLNEEGDLPGDRFSASR-PSLTRSSLTIKSAEPEDSAVYLCASSLGGGADEA----YFGPG 105


                ....*
gi 673442   135 TSVTV 139
Cdd:cd05899 106 TRLTV 110
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 26-139 9.62e-09

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 49.43  E-value: 9.62e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 673442       26 SGPGLVAPSQSLSITCTVSGFSltSYGVHWVRQPPGKGLEGlgviwaggstnynsalmSRLSISKDNSKSqvFLKMNSLQ 105
Cdd:smart00410   1 PPSVTVKEGESVTLSCEASGSP--PPEVTWYKQGGKLLAES-----------------GRFSVSRSGSTS--TLTISNVT 59

                           90       100       110
                   ....*....|....*....|....*....|....
gi 673442      106 IDDTAMYYCARSPTSTMDTpyamdywgQGTSVTV 139
Cdd:smart00410  60 PEDSGTYTCAATNSSGSAS--------SGTTLTV 85
IgV_TCR_gammadelta cd20988
Gammadelta T-cell antigen receptor, variable (V) domain; The members here are composed of the ...
 31-139 1.37e-05

Gammadelta T-cell antigen receptor, variable (V) domain; The members here are composed of the immunoglobulin (Ig) variable (V) domain of the gamma/delta T-cell receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are heterodimers consisting of alpha and beta chains or gamma and delta chains. Each chain contains a variable (V) and a constant (C) region. The majority of T cells contain alpha/beta TCRs, but a small subset contain gamma/delta TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. Gamma/delta TCRs recognize intact protein antigens; they recognize protein antigens directly and without antigen processing, and MHC independently of the bound peptide. Gamma/delta T cells can also be stimulated by non-peptide antigens such as small phosphate- or amine-containing compounds. The variable domain of gamma/delta TCRs is responsible for antigen recognition and is located at the N-terminus of the receptor. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409580  Cd Length: 114  Bit Score: 41.77  E-value: 1.37e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 673442    31 VAPSQSLSITCTVSGFSLTSYGVHWVRQPPGKGLEglgVIWAGGSTnYNSALMSRLSISKDNSKSQVFLKMNSLQIDDTA 110
Cdd:cd20988  10 VSVGKPVTLKCSMKGEAISNYYINWYRKTQGNTMT---FIYREGGI-YGPGFKDNFRGDIDSSNNLAVLKILEASERDEG 85

                        90       100
                ....*....|....*....|....*....
gi 673442   111 MYYCArSPTSTMDTPYAMDYWGQGTSVTV 139
Cdd:cd20988  86 SYYCA-SDTPGGGREYDPLIFGKGTYLTV 113
IgV_TCR_delta cd07706
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) delta chain; The members here ...
 31-139 5.57e-05

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) delta chain; The members here are composed of the immunoglobulin (Ig) variable (V) domain of the delta chain of gamma/delta T-cell receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are heterodimers consisting of alpha and beta chains or gamma and delta chains. Each chain contains a variable (V) and a constant (C) region. The majority of T cells contain alpha/beta TCRs, but a small subset contain gamma/delta TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. Gamma/delta TCRs recognize intact protein antigens; they recognize protein antigens directly and without antigen processing, and MHC independently of the bound peptide. Gamma/delta T cells can also be stimulated by non-peptide antigens such as small phosphate- or amine-containing compounds. The variable domain of gamma/delta TCRs is responsible for antigen recognition and is located at the N-terminus of the receptor. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409503  Cd Length: 112  Bit Score: 39.81  E-value: 5.57e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 673442    31 VAPSQSLSITCTVSGfSLTSYGVHWVRQPPGKGLEGLgviwAGGSTNYNSALMSRLSISKDNSKSQVFLKMNSLQIDDTA 110
Cdd:cd07706  11 VQVGEEVTLNCRYET-SWTNYYLFWYKQLPSGEMTFL----IRQDSSEQNAKSGRYSVNFQKAQKSISLTISALQLEDSA 85

                        90       100       110
                ....*....|....*....|....*....|.
gi 673442   111 MYYCARSptstmdTPYAMD--YWGQGTSVTV 139
Cdd:cd07706  86 KYFCALS------LPYDTDklIFGKGTRLTV 110
IgV_L_kappa cd04980
Immunoglobulin (Ig) light chain, kappa type, variable (V) domain; The members here are ...
 21-139 2.01e-04

Immunoglobulin (Ig) light chain, kappa type, variable (V) domain; The members here are composed of the immunoglobulin (Ig) light chain, kappa type, variable (V) domain. This group contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. There are two types of light chains: kappa and lambda, each composed of a constant domain (CL) and a variable domain (VL). There are five types of heavy chains (alpha, gamma, delta, epsilon, and mu), which determines the type of immunoglobulin formed: IgA, IgG, IgD, IgE, and IgM, respectively. In higher vertebrates, there are two types of light chain, designated kappa and lambda, which seem to be functionally identical, and can associate with any of the heavy chains.


Pssm-ID: 409369  Cd Length: 106  Bit Score: 38.14  E-value: 2.01e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 673442    21 VQLKESGPGL-VAPSQSLSITCTVSGfSLTSYGVHWVRQPPGKGLEGLgvIWAGgsTNYNSALMSRLSISkdNSKSQVFL 99
Cdd:cd04980   1 IVMTQSPASLsVSPGERVTISCKASQ-SISSNYLAWYQQKPGQAPKLL--IYYA--STLHSGVPSRFSGS--GSGTDFTL 73

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 673442   100 KMNSLQIDDTAMYYCARSPTstmdTPYAmdyWGQGTSVTV 139
Cdd:cd04980  74 TISSVEPEDAAVYYCQQGYT----FPYT---FGGGTKLEI 106
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH