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Conserved domains on  [gi|1003717219|emb|CAB04640|]
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Seven TM Receptor [Caenorhabditis elegans]

Protein Classification

class R serpentine receptor( domain architecture ID 10563422)

class R serpentine receptor, also known as seven TM receptor (Str), belongs to a family of seven-transmembrane (7TM) G protein-coupled receptors involved in chemoreception, a central sense of soil nematodes like Caenorhabditis elegans

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 10-315 4.21e-109

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


:

Pssm-ID: 402099  Cd Length: 307  Bit Score: 320.17  E-value: 4.21e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003717219  10 TYYAETIGFCLSISFNFILLLLISEMPKKIFGSYKYLMLSFSVLGMFYSCCNVLAKPNLYITDVSFAAFNILKNTGFSKS 89
Cdd:pfam10326   1 LHIIQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVDLKDLGLSKS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003717219  90 FGSIAIAIYSSCYGMMIVLLTINFYYRYLSVTCPAKLTRFSAKNSPIWVFLILFNSSTWFVLSYFVNGPTSMKDEILQPE 169
Cdd:pfam10326  81 VGQILLALYCGFYGVSISLLAVQFIYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003717219 170 LLQAYCMQPEDYAYVGPQYFYKDE-GEMKFHLPSWIASGGMAFTMFITNTLLTYFGIETYRHLNKIGSIAGIEYRELQRQ 248
Cdd:pfam10326 161 LLENYNLDIDEVAYVGPVYYPTDEnGSKVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLGSEKTRKLQKQ 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1003717219 249 LFRTLVIQTAIPMVFMYFPISCMFLFPIFGIKAESLANVVPIAVAIYPCFEPLAAMYCIKSFQKRIF 315
Cdd:pfam10326 241 LFKALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNAIK 307
 
Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 10-315 4.21e-109

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 320.17  E-value: 4.21e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003717219  10 TYYAETIGFCLSISFNFILLLLISEMPKKIFGSYKYLMLSFSVLGMFYSCCNVLAKPNLYITDVSFAAFNILKNTGFSKS 89
Cdd:pfam10326   1 LHIIQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVDLKDLGLSKS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003717219  90 FGSIAIAIYSSCYGMMIVLLTINFYYRYLSVTCPAKLTRFSAKNSPIWVFLILFNSSTWFVLSYFVNGPTSMKDEILQPE 169
Cdd:pfam10326  81 VGQILLALYCGFYGVSISLLAVQFIYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003717219 170 LLQAYCMQPEDYAYVGPQYFYKDE-GEMKFHLPSWIASGGMAFTMFITNTLLTYFGIETYRHLNKIGSIAGIEYRELQRQ 248
Cdd:pfam10326 161 LLENYNLDIDEVAYVGPVYYPTDEnGSKVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLGSEKTRKLQKQ 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1003717219 249 LFRTLVIQTAIPMVFMYFPISCMFLFPIFGIKAESLANVVPIAVAIYPCFEPLAAMYCIKSFQKRIF 315
Cdd:pfam10326 241 LFKALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNAIK 307
 
Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 10-315 4.21e-109

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 320.17  E-value: 4.21e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003717219  10 TYYAETIGFCLSISFNFILLLLISEMPKKIFGSYKYLMLSFSVLGMFYSCCNVLAKPNLYITDVSFAAFNILKNTGFSKS 89
Cdd:pfam10326   1 LHIIQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVDLKDLGLSKS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003717219  90 FGSIAIAIYSSCYGMMIVLLTINFYYRYLSVTCPAKLTRFSAKNSPIWVFLILFNSSTWFVLSYFVNGPTSMKDEILQPE 169
Cdd:pfam10326  81 VGQILLALYCGFYGVSISLLAVQFIYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003717219 170 LLQAYCMQPEDYAYVGPQYFYKDE-GEMKFHLPSWIASGGMAFTMFITNTLLTYFGIETYRHLNKIGSIAGIEYRELQRQ 248
Cdd:pfam10326 161 LLENYNLDIDEVAYVGPVYYPTDEnGSKVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLGSEKTRKLQKQ 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1003717219 249 LFRTLVIQTAIPMVFMYFPISCMFLFPIFGIKAESLANVVPIAVAIYPCFEPLAAMYCIKSFQKRIF 315
Cdd:pfam10326 241 LFKALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNAIK 307
7TM_GPCR_Srj pfam10319
Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis ...
 11-314 1.42e-29

Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srj is part of the Str superfamily of chemoreceptors. The srj family is designated as the out-group based on its location in preliminary phylogenetic analyses of the entire superfamily. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 370974  Cd Length: 310  Bit Score: 115.03  E-value: 1.42e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003717219  11 YYAETIGFCLSISFNFILLLLISEMPKKIFGSYKYLMLSFSVLGMFYSCCNVLAKpnLYITDVSFAAFNILKNTGFSKS- 89
Cdd:pfam10319   8 YYIPKIFGVLSFIVNPIFIYLIFTEKSSQFGNYRYLLLFFAIFNLIYSVVELLVP--LDIHSYRYCFVVFVSDGPFFEYs 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003717219  90 -FGSIAIAIYSSCYGMMIVLLTINFYYRYLSVTCPAKLTR-FSAKNSPIWVFLILFNSSTWFVLSYFVNGPTSMKDEILQ 167
Cdd:pfam10319  86 eLGQHALSARCSFISASYAVLLIHFIYRYLVLFNPQLTRHyFRPWGILISILFFLFHGSVWTAICYFLLRANDEIRDYIR 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003717219 168 PELLQAYCMQPEDYAYVGPQYFykdEGEMKFHLPSWIASGGMAFTMFITNTLLTYFGIETYRHLNKIGSIAGIEYRELQR 247
Cdd:pfam10319 166 EDFRETYGVDSMDINMLGALYW---EASDETVFRSWLGILLLTVISVYSIILYIVLGYKIMRKLNKMSVTMSKKTKRLQK 242

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003717219 248 QLFRTLVIQTAIPMVFMYFPisCMFLF--PIFGIKAESLANVVP-IAVAIYPCFEPLAAMYCIKSFQKRI 314
Cdd:pfam10319 243 QLLKALIVQTIIPICISFSP--CVLAWysPIFGIDLGRWNNYLEvIALSAFPFIDPLAIILCLPVYRNRI 310
7TM_GPCR_Srd pfam10317
Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis ...
 15-314 1.59e-10

Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srd is part of the larger Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402094  Cd Length: 292  Bit Score: 61.03  E-value: 1.59e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003717219  15 TIGFCLSISFNFILLLLISEMPKKIFGSYKYLMLSFSVLGMFYSCCNVLAKPNLYITDVSFAafniLKNTGFSKSFGSIA 94
Cdd:pfam10317   6 PIFFILGLILNLLLLYLIIFKSPKSLKTYRILLLNTAITQIISCILAFFTQQRIIPNGVSMA----LISYGPCKYFGPWF 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003717219  95 ----IAIYSSCYGMMIVLLTINFYYRYLSVTCPakltRFSAKNSPIWVFLILFNSSTWFVLSYFVNGPTsmkdEILQPEL 170
Cdd:pfam10317  82 cysgYSLLQHFLLHSGWSLLLTFYYRYYILKHV----DPKRKKLILLIIIHYIPSLSQLIVIFLSPTDF----LPVEALT 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003717219 171 LQAYcmqpedyayvgPQYFYKDE---GEMKF-HLPSWIASGGMAFTMFITNTLLTYFGIETYRHLNKIGSIAGIEYRELQ 246
Cdd:pfam10317 154 KELH-----------PNYNLTDYtvtGFSDLqSFPALINTLIMTIPVFPIPIIILILRRKILKLLNSNSVNMSPTTKAQH 222

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003717219 247 RQLFRTLVIQTAIPMVFmYFPISCMFLFPIFGIkAESLA--NVVPIAVAIYPCFEPLAAMYCIKSFQKRI 314
Cdd:pfam10317 223 RQLIKGLTIQALLPLFS-YIPGVTLYLLSQLTG-TEFLIleYFIFVLPALPPLLDPLITIYFVTPYRRAI 290
7TM_GPCR_Srh pfam10318
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
 38-320 4.55e-06

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402095  Cd Length: 302  Bit Score: 47.54  E-value: 4.55e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003717219  38 KIFGSYKYLMLSFSVLGMFYSCC-NVLAKPNLYITDVSFAAFNILKNTGFSksfGSIAIAIYSSCYGMMIVLLTINFYYR 116
Cdd:pfam10318  34 KKMKSVKWSLLNLHFWSALLDLSlSFLTIPYIFLPALAGYPLGLLSYLGVP---TPIQFYIGVTSLALVGVSIILLFENR 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003717219 117 YlSVTCPAKLTRFSAKNSPIWVFLILFNSSTWFVLSYF-VNGPTSMKDEILQ--PELlqaycmqpedyayvgPQYFYKDE 193
Cdd:pfam10318 111 Y-SILFTNKKRITWKKTRVLYLIFNYIIALLFLIPIYLnIPDQEAAKLKVLKklPCL---------------PPEFFDNP 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003717219 194 GEMKFHLPSWIASGGMAFTMFITNTLLTYFGIETYRHLNKIGSIA-GIEYRELQRQLFRTLVIQTAIPMVFMYFPISCMF 272
Cdd:pfam10318 175 PVFVLAIDSTYFLICIVLLILILIIQILFFVFLTIYYLFKSVKSSlSKKTRKLQKKFFIALIIQVSIPLIVILIPLIYIL 254

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1003717219 273 LFPIFGIKAESLANVVPIAVAIYPCFEPLAAMYCIKSFQKRIFSILTC 320
Cdd:pfam10318 255 FSIIFGYYNQALNNLLFIIISLHGLLSTIAMLLVHKPYRKFVLSLFKK 302
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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