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Conserved domains on  [gi|1849248516|emb|CAB4633505|]
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unannotated protein [freshwater metagenome]

Protein Classification

superoxide dismutase( domain architecture ID 11427369)

Mn/Fe superoxide dismutase eliminates superoxide radicals by catalyzing their conversion into hydrogen peroxide and oxygen

CATH:  1.10.287.990
EC:  1.15.1.1
Gene Ontology:  GO:0046872|GO:0004784|GO:0006801
PubMed:  3345848|3315461

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SodA COG0605
Superoxide dismutase [Inorganic ion transport and metabolism];
6-193 3.05e-101

Superoxide dismutase [Inorganic ion transport and metabolism];


:

Pssm-ID: 440370 [Multi-domain]  Cd Length: 192  Bit Score: 290.49  E-value: 3.05e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1849248516   6 LPDLAYDYAALEPHISARIMELHHSKHHKAYVDGANNALAGLEEARETgNFANI-----NRLEKDLAFHLGGHINHSIFW 80
Cdd:COG0605     2 LPPLPYAYDALEPHISAETMELHHDKHHQAYVNNLNAALEGLAELEDK-SLEEIikklsEELKRALRNNAGGHWNHTLFW 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1849248516  81 TNLAPTSGGVPEGELSAAINEFFGSFDKFQAHFTAASMGIQGSGWGVLSFDPvGKRLIIQQLFDQQGNTAQATIPLLQLD 160
Cdd:COG0605    81 ENLSPNGGGEPTGELAAAIEADFGSFDAFKEEFKAAAAGRFGSGWAWLVVDK-DGKLEIVSTPNQDNPLMAGGTPLLGLD 159

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1849248516 161 MWEHAFYLDYQNVKADYVKAFWNIVDWANVSKR 193
Cdd:COG0605   160 VWEHAYYLDYQNRRPDYVDAFWNVVNWDFVEKR 192
 
Name Accession Description Interval E-value
SodA COG0605
Superoxide dismutase [Inorganic ion transport and metabolism];
6-193 3.05e-101

Superoxide dismutase [Inorganic ion transport and metabolism];


Pssm-ID: 440370 [Multi-domain]  Cd Length: 192  Bit Score: 290.49  E-value: 3.05e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1849248516   6 LPDLAYDYAALEPHISARIMELHHSKHHKAYVDGANNALAGLEEARETgNFANI-----NRLEKDLAFHLGGHINHSIFW 80
Cdd:COG0605     2 LPPLPYAYDALEPHISAETMELHHDKHHQAYVNNLNAALEGLAELEDK-SLEEIikklsEELKRALRNNAGGHWNHTLFW 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1849248516  81 TNLAPTSGGVPEGELSAAINEFFGSFDKFQAHFTAASMGIQGSGWGVLSFDPvGKRLIIQQLFDQQGNTAQATIPLLQLD 160
Cdd:COG0605    81 ENLSPNGGGEPTGELAAAIEADFGSFDAFKEEFKAAAAGRFGSGWAWLVVDK-DGKLEIVSTPNQDNPLMAGGTPLLGLD 159

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1849248516 161 MWEHAFYLDYQNVKADYVKAFWNIVDWANVSKR 193
Cdd:COG0605   160 VWEHAYYLDYQNRRPDYVDAFWNVVNWDFVEKR 192
PLN02471 PLN02471
superoxide dismutase [Mn]
 4-195 3.35e-60

superoxide dismutase [Mn]


Pssm-ID: 215262  Cd Length: 231  Bit Score: 188.19  E-value: 3.35e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1849248516   4 YVLPDLAYDYAALEPHISARIMELHHSKHHKAYVDGANNALAGLEEARETGNFANINRLEKDLAFHLGGHINHSIFWTNL 83
Cdd:PLN02471   31 FTLPDLPYDYGALEPAISGEIMQLHHQKHHQTYVTNYNKALEQLDQAVEKGDASAVVKLQSAIKFNGGGHVNHSIFWKNL 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1849248516  84 APTS---GGVPEGELSAAINEFFGSFDKFQAHFTAASMGIQGSGWGVLSFDPVGKRLIIQQLFDQQG--NTAQATIPLLQ 158
Cdd:PLN02471  111 APVSeggGEPPHGSLGWAIDEHFGSLEALVKKMSAEGAAVQGSGWVWLGLDKELKKLVVETTANQDPlvTKGPSLVPLLG 190

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1849248516 159 LDMWEHAFYLDYQNVKADYVKAFWNIVDWANVSKRFE 195
Cdd:PLN02471  191 IDVWEHAYYLQYKNVRPDYLKNIWKVMNWKYASEVYE 227
Sod_Fe_C pfam02777
Iron/manganese superoxide dismutases, C-terminal domain; superoxide dismutases (SODs) catalyze ...
 91-193 1.77e-53

Iron/manganese superoxide dismutases, C-terminal domain; superoxide dismutases (SODs) catalyze the conversion of superoxide radicals to hydrogen peroxide and molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the Mn/Fe-binding family is one. In humans, there is a cytoplasmic Cu/Zn SOD, and a mitochondrial Mn/Fe SOD. C-terminal domain is a mixed alpha/beta fold.


Pssm-ID: 460691  Cd Length: 102  Bit Score: 166.45  E-value: 1.77e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1849248516  91 PEGELSAAINEFFGSFDKFQAHFTAASMGIQGSGWGVLSFDPVGKrLIIQQLFDQQGNTAQATIPLLQLDMWEHAFYLDY 170
Cdd:pfam02777   1 PTGALAEAIEKDFGSFDAFKEEFNAAAAGVFGSGWAWLVYDPDGK-LEIVTTPNQDNPLTDGLTPLLGLDVWEHAYYLDY 79

                          90       100
                  ....*....|....*....|...
gi 1849248516 171 QNVKADYVKAFWNIVDWANVSKR 193
Cdd:pfam02777  80 QNRRADYVKAFWNVVNWDEVEKR 102
 
Name Accession Description Interval E-value
SodA COG0605
Superoxide dismutase [Inorganic ion transport and metabolism];
6-193 3.05e-101

Superoxide dismutase [Inorganic ion transport and metabolism];


Pssm-ID: 440370 [Multi-domain]  Cd Length: 192  Bit Score: 290.49  E-value: 3.05e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1849248516   6 LPDLAYDYAALEPHISARIMELHHSKHHKAYVDGANNALAGLEEARETgNFANI-----NRLEKDLAFHLGGHINHSIFW 80
Cdd:COG0605     2 LPPLPYAYDALEPHISAETMELHHDKHHQAYVNNLNAALEGLAELEDK-SLEEIikklsEELKRALRNNAGGHWNHTLFW 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1849248516  81 TNLAPTSGGVPEGELSAAINEFFGSFDKFQAHFTAASMGIQGSGWGVLSFDPvGKRLIIQQLFDQQGNTAQATIPLLQLD 160
Cdd:COG0605    81 ENLSPNGGGEPTGELAAAIEADFGSFDAFKEEFKAAAAGRFGSGWAWLVVDK-DGKLEIVSTPNQDNPLMAGGTPLLGLD 159

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1849248516 161 MWEHAFYLDYQNVKADYVKAFWNIVDWANVSKR 193
Cdd:COG0605   160 VWEHAYYLDYQNRRPDYVDAFWNVVNWDFVEKR 192
PLN02471 PLN02471
superoxide dismutase [Mn]
 4-195 3.35e-60

superoxide dismutase [Mn]


Pssm-ID: 215262  Cd Length: 231  Bit Score: 188.19  E-value: 3.35e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1849248516   4 YVLPDLAYDYAALEPHISARIMELHHSKHHKAYVDGANNALAGLEEARETGNFANINRLEKDLAFHLGGHINHSIFWTNL 83
Cdd:PLN02471   31 FTLPDLPYDYGALEPAISGEIMQLHHQKHHQTYVTNYNKALEQLDQAVEKGDASAVVKLQSAIKFNGGGHVNHSIFWKNL 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1849248516  84 APTS---GGVPEGELSAAINEFFGSFDKFQAHFTAASMGIQGSGWGVLSFDPVGKRLIIQQLFDQQG--NTAQATIPLLQ 158
Cdd:PLN02471  111 APVSeggGEPPHGSLGWAIDEHFGSLEALVKKMSAEGAAVQGSGWVWLGLDKELKKLVVETTANQDPlvTKGPSLVPLLG 190

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1849248516 159 LDMWEHAFYLDYQNVKADYVKAFWNIVDWANVSKRFE 195
Cdd:PLN02471  191 IDVWEHAYYLQYKNVRPDYLKNIWKVMNWKYASEVYE 227
Sod_Fe_C pfam02777
Iron/manganese superoxide dismutases, C-terminal domain; superoxide dismutases (SODs) catalyze ...
 91-193 1.77e-53

Iron/manganese superoxide dismutases, C-terminal domain; superoxide dismutases (SODs) catalyze the conversion of superoxide radicals to hydrogen peroxide and molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the Mn/Fe-binding family is one. In humans, there is a cytoplasmic Cu/Zn SOD, and a mitochondrial Mn/Fe SOD. C-terminal domain is a mixed alpha/beta fold.


Pssm-ID: 460691  Cd Length: 102  Bit Score: 166.45  E-value: 1.77e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1849248516  91 PEGELSAAINEFFGSFDKFQAHFTAASMGIQGSGWGVLSFDPVGKrLIIQQLFDQQGNTAQATIPLLQLDMWEHAFYLDY 170
Cdd:pfam02777   1 PTGALAEAIEKDFGSFDAFKEEFNAAAAGVFGSGWAWLVYDPDGK-LEIVTTPNQDNPLTDGLTPLLGLDVWEHAYYLDY 79

                          90       100
                  ....*....|....*....|...
gi 1849248516 171 QNVKADYVKAFWNIVDWANVSKR 193
Cdd:pfam02777  80 QNRRADYVKAFWNVVNWDEVEKR 102
PRK10925 PRK10925
superoxide dismutase [Mn];
1-198 3.54e-48

superoxide dismutase [Mn];


Pssm-ID: 182843  Cd Length: 206  Bit Score: 156.62  E-value: 3.54e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1849248516   1 MSpYVLPDLAYDYAALEPHISARIMELHHSKHHKAYVDGANNALAGLEEARETGNFANINRLEKDLA-------FHLGGH 73
Cdd:PRK10925    1 MS-YTLPSLPYAYDALEPHFDKQTMEIHHTKHHQTYVNNANAALESLPEFANLPVEELITKLDQLPAdkktvlrNNAGGH 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1849248516  74 INHSIFWTNLapTSGGVPEGELSAAINEFFGSFDKFQAHFTAASMGIQGSGWGVLSFDpvGKRLIIQQLFDQQGNTAQAT 153
Cdd:PRK10925   80 ANHSLFWKGL--KKGTTLQGDLKAAIERDFGSVDNFKAEFEKAAATRFGSGWAWLVLK--GDKLAVVSTANQDSPLMGEA 155

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1849248516 154 I------PLLQLDMWEHAFYLDYQNVKADYVKAFWNIVDWANVSKRFEAAR 198
Cdd:PRK10925  156 IsgasgfPILGLDVWEHAYYLKFQNRRPDYIKEFWNVVNWDEAAARFAAKK 206
PRK10543 PRK10543
superoxide dismutase [Fe];
6-196 3.03e-44

superoxide dismutase [Fe];


Pssm-ID: 182534  Cd Length: 193  Bit Score: 146.25  E-value: 3.03e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1849248516   6 LPDLAYDYAALEPHISARIMELHHSKHHKAYVDGANNALAGLEEARETgnFANINRLEKDLAFHLGGHI-NHSIFWTNLA 84
Cdd:PRK10543    5 LPALPYAKDALAPHISAETLEYHYGKHHQTYVTNLNNLIKGTAFEGKS--LEEIVRSSEGGVFNNAAQVwNHTFYWNCLA 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1849248516  85 PTSGGVPEGELSAAINEFFGSFDKFQAHFTAASMGIQGSGWGVLSFDPVGKRLIIQQLFDQQGNTAQATiPLLQLDMWEH 164
Cdd:PRK10543   83 PNAGGEPTGKVAEAIAASFGSFADFKAQFTDAAIKNFGSGWTWLVKNADGKLAIVSTSNAGTPLTTDAT-PLLTVDVWEH 161

                         170       180       190
                  ....*....|....*....|....*....|..
gi 1849248516 165 AFYLDYQNVKADYVKAFWNIVDWANVSKRFEA 196
Cdd:PRK10543  162 AYYIDYRNARPGYLEHFWALVNWEFVAKNLAA 193
PTZ00078 PTZ00078
Superoxide dismutase [Fe]; Provisional
 7-197 1.21e-41

Superoxide dismutase [Fe]; Provisional


Pssm-ID: 185432 [Multi-domain]  Cd Length: 193  Bit Score: 139.54  E-value: 1.21e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1849248516   7 PDLAYDYAALEPHISARIMELHHSKHHKAYVDGANNALAGleEARETGNFANINRLEKDLAFHLGGHI-NHSIFWTNLAP 85
Cdd:PTZ00078    1 PKLPYGLKELSPHLSEETLKFHYSKHHAGYVNKLNGLIKG--TPLENKTLEELIKEYSGAVFNNAAQIwNHNFYWLSMGP 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1849248516  86 TSGGVPEGELSAAINEFFGSFDKFQAHFTAASMGIQGSGWGVLSFDPVGKrLIIQQLFDQ----QGNTAqatIPLLQLDM 161
Cdd:PTZ00078   79 NGGGEPTGEIKEKIDEKFGSFDNFKNEFSNVLSGHFGSGWGWLVLKNDGK-LEIVQTHDAgnpiKDNTG---KPLLTCDI 154

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1849248516 162 WEHAFYLDYQNVKADYVKAFWNIVDWANVSKRFEAA 197
Cdd:PTZ00078  155 WEHAYYIDYRNDRASYVNSWWNKVNWDFANKNLKKL 190
PLN02685 PLN02685
iron superoxide dismutase
 11-202 6.38e-39

iron superoxide dismutase


Pssm-ID: 215369  Cd Length: 299  Bit Score: 135.51  E-value: 6.38e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1849248516  11 YDYAALEPHISARIMELHHSKHHKAYVDGANNALAGLE---EARETGNFANINRLEKDLAFHLGGHI-NHSIFWTNLAPT 86
Cdd:PLN02685   54 YPLDALEPHMSRETLEYHWGKHHRAYVDNLNKQIVGTEldgMSLEDVVLITYNKGDMLPAFNNAAQAwNHEFFWESMKPG 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1849248516  87 SGGVPEGELSAAINEFFGSFDKFQAHFTAASMGIQGSGWGVLSF-----------DPV----GKRLIIQQLFDQQGNTAQ 151
Cdd:PLN02685  134 GGGKPSGELLQLIERDFGSFERFVEEFKSAAATQFGSGWAWLAYkanrldvgnavNPCpseeDKKLVVVKSPNAVNPLVW 213

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1849248516 152 ATIPLLQLDMWEHAFYLDYQNVKADYVKAFW-NIVDWANVSKRFEAARAGAS 202
Cdd:PLN02685  214 DYSPLLTIDVWEHAYYLDFQNRRPDYISTFMeKLVSWEAVSARLESAKARAA 265
Sod_Fe_N pfam00081
Iron/manganese superoxide dismutases, alpha-hairpin domain; superoxide dismutases (SODs) ...
 3-84 1.43e-37

Iron/manganese superoxide dismutases, alpha-hairpin domain; superoxide dismutases (SODs) catalyze the conversion of superoxide radicals to hydrogen peroxide and molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the Mn/Fe-binding family is one. In humans, there is a cytoplasmic Cu/Zn SOD, and a mitochondrial Mn/Fe SOD. N-terminal domain is a long alpha antiparallel hairpin. A small fragment of YTRE_LEPBI matches well - sequencing error?


Pssm-ID: 425457  Cd Length: 82  Bit Score: 125.50  E-value: 1.43e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1849248516   3 PYVLPDLAYDYAALEPHISARIMELHHSKHHKAYVDGANNALAGLEEARETGNFANINRLEKDLAFHLGGHINHSIFWTN 82
Cdd:pfam00081   1 SYELPDLPYAYDALEPHISKETMEIHHTKHHQTYVNNLNAALEGLEEARKPLEELIIKALLGGLFNNGGGHWNHSLFWKN 80


                  ..
gi 1849248516  83 LA 84
Cdd:pfam00081  81 LS 82
PLN02184 PLN02184
superoxide dismutase [Fe]
 4-202 3.06e-37

superoxide dismutase [Fe]


Pssm-ID: 177838  Cd Length: 212  Bit Score: 128.71  E-value: 3.06e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1849248516   4 YVLPDLAYDYAALEPHISARIMELHHSKHHKAYVDGANNALAGLE---EARETGNFANINRLEKDLAFHLGGHI-NHSIF 79
Cdd:PLN02184   11 YVLKPPPFALDALEPHMSKQTLEFHWGKHHRAYVDNLKKQVLGTElegKPLEHIIHSTYNNGDLLPAFNNAAQAwNHEFF 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1849248516  80 WTNLAPTSGGVPEGELSAAINEFFGSFDKFQAHFTAASMGIQGSGWGVLSFdpVGKRLIIQQLFDQQGNTAQATIPLLQL 159
Cdd:PLN02184   91 WESMKPGGGGKPSGELLALLERDFTSYEKFYEEFNAAAATQFGAGWAWLAY--SNEKLKVVKTPNAVNPLVLGSFPLLTI 168

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1849248516 160 DMWEHAFYLDYQNVKADYVKAFW-NIVDWANVSKRFEAARAGAS 202
Cdd:PLN02184  169 DVWEHAYYLDFQNRRPDYIKTFMtNLVSWEAVSARLEAAKAASA 212
PLN02622 PLN02622
iron superoxide dismutase
 4-205 7.20e-37

iron superoxide dismutase


Pssm-ID: 166263 [Multi-domain]  Cd Length: 261  Bit Score: 129.36  E-value: 7.20e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1849248516   4 YVLPDLAYDYAALEPHISARIMELHHSKHHKAYVDGANNALAG--------LEEARETgNFANINRLEKdlaFHLGGHI- 74
Cdd:PLN02622   48 YGLKTPPYPLDALEPYMSRRTLEVHWGEHHRGYVEGLNKQLAKddilygytMDELVKV-TYNNGNPLPE---FNNAAQVw 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1849248516  75 NHSIFWTNLAPTSGGVPEGELSAAINEFFGSFDKFQAHFTAASMGIQGSGWGVLSFDPVGKRLIIQQLFDQQGNTAQATI 154
Cdd:PLN02622  124 NHDFFWESMQPGGGDMPELGVLEQIEKDFGSFTNFREKFTEAALTLFGSGWVWLVLKREERRLEVVKTSNAINPLVWDDI 203

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1849248516 155 PLLQLDMWEHAFYLDYQNVKADYVKAFWN-IVDWANVSKRFeaARAGASATL 205
Cdd:PLN02622  204 PIICLDVWEHAYYLDYKNDRGKYVNAFMNhLVSWNAAMARM--ARAEAFVNL 253
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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