|
Name |
Accession |
Description |
Interval |
E-value |
| IleS |
COG0060 |
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA ... |
34-971 |
0e+00 |
|
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439830 [Multi-domain] Cd Length: 931 Bit Score: 898.67 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 34 YSESLCLPKTSFPIKPNVKGNNEKYFKsitsdlyEWQKENL------NKED--SFVLLDGPPFANGRLHIGHALNKILKD 105
Cdd:COG0060 1 YKETLNLPKTDFPMRANLPKREPEILK-------FWEENDIyeksreARAGrpKFVLHDGPPYANGDIHIGHALNKILKD 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 106 IINRWQLLKGRSVHYVPGWDCHGLPIESKAIKANAERKSS------LEIRKIAKDFANSAVQEQLMMFQRMAVMGDWPSR 179
Cdd:COG0060 74 IIVRYKTMRGFDVPYVPGWDCHGLPIELKVEKELGIKKKDiekvgiAEFREKCREYALKYVDEQREDFKRLGVWGDWDNP 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 180 YITMSDKFEIAELKVFLSLLQKDLIFRQNKPVYWSSSSRSALAESEIEYDDnHVSTSIYFTFPVNSfSIDGCEYNNVKAL 259
Cdd:COG0060 154 YLTMDPEYEESIWWALKKLYEKGLLYKGLKPVPWCPRCGTALAEAEVEYKD-VTSPSIYVKFPVKD-EKALLLLEDAYLV 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 260 VWTTTPWTIPSNLALSYHPEINYGLYQH-NNSIYLMSDNLVPnlDFMQ-----GAKRLASCPSDIISSFTYENPLL---- 329
Cdd:COG0060 232 IWTTTPWTLPANLAVAVHPDIDYVLVEVtGGERLILAEALVE--AVLKelgieDYEVLATFKGAELEGLRYEHPFYyvvg 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 330 PKQSFPFLQSNYVTNDIGTGIVHVAPGHGMEDYLLGLENNLRPFSPLDDYGRYTKEAldGSLEGLEVLgDGGKKVISIMK 409
Cdd:COG0060 310 YDRAHPVILGDYVTTEDGTGIVHTAPGHGEDDFEVGKKYGLPVLNPVDDDGRFTEEA--PLFAGLFVK-DANPAIIEDLK 386
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 410 NQNMIVKVSPYKHRYPYDWRTHKPLILRATPQWFISLENERKTAIKALDSVKMIPPNSRARLLGFLNGRPEWCISRQRAW 489
Cdd:COG0060 387 ERGALLAREKITHSYPHCWRCKTPLIYRATPQWFISMDKLRDRALEAIEKVNWIPEWGEGRFGNMLENRPDWCISRQRYW 466
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 490 GLPIPVLYEKGTKIPLLTVKSVSYIIEKMEVEGVDSWFNDTEnngHAQWVHPDYRN----KEYIRGTETLDVWFDSG-TS 564
Cdd:COG0060 467 GVPIPIWVCEDCGELHRTEEVIGSVAELLEEEGADAWFELDL---HRPFLDETLKCpkcgGTMRRVPDVLDVWFDSGsMH 543
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 565 WTTIAPRKNKPLI-DLCLEGSDQHRGWFQSLLLTYTAYQSKpeAPFSTLFTHGFIFDERGQKQSKSLGNVTDPEDVINgk 643
Cdd:COG0060 544 FAVLENREELHFPaDFYLEGSDQTRGWFYSSLLTSTALFGR--APYKNVLTHGFVLDEDGRKMSKSLGNVVDPQEVID-- 619
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 644 llkgkklPYGVDLLRLWVASCDSTNDTNLGPNILTQVGESLKKWRLTSRFCLGNLHDWN-TSSSVDVGELRGIDKLALVQ 722
Cdd:COG0060 620 -------KYGADILRLWVASSDYWGDLRFSDEILKEVRDVYRRLRNTYRFLLANLDDFDpAEDAVPYEDLPELDRWILSR 692
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 723 LDKFQTEIRELYESYSINKVVHHLNYFMNSFLSSTYFDAVKDRLYADLPNSVSRRSVQTVLYHSLLTLIWAISPITPLLA 802
Cdd:COG0060 693 LNELIKEVTEAYDNYDFHRAYRALHNFCVEDLSNWYLDISKDRLYTEAADSLDRRAAQTTLYEVLETLVRLLAPILPFTA 772
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 803 QEIWQSLPDSYLNSSYQTPFHAGETHLIS-SLRSKVDLldrkflikeylvLQQLKYSINLLITAARENLTIKNSLEAYVV 881
Cdd:COG0060 773 EEIWQNLPGEAEESVHLADWPEVDEELIDeELEAKWDL------------VREVRSAVLKALEAARKEKLIRQPLEAAVV 840
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 882 IkSKSQSLLSFLKNYSSDLPFLFNTSKVFINEIPENLKLASVTQPEVqlDYGVANISLFFSNQQKCLRCWMHT-----AH 956
Cdd:COG0060 841 L-YADEELAAALESLGDLLAEELNVSEVELVDDAEDLGKDALKALDV--EGISVTVEVEKADGEKCERCWHYEvgwtpEH 917
|
970
....*....|....*
gi 5701963 957 EdGLCDRCESVLAQL 971
Cdd:COG0060 918 E-GLCRRCVRRVQGL 931
|
|
| PLN02843 |
PLN02843 |
isoleucyl-tRNA synthetase |
66-972 |
0e+00 |
|
isoleucyl-tRNA synthetase
Pssm-ID: 215452 [Multi-domain] Cd Length: 974 Bit Score: 831.34 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 66 LYEWQKENLNKEdSFVLLDGPPFANGRLHIGHALNKILKDIINRWQLLKGRSVHYVPGWDCHGLPIESKAIKA--NAERK 143
Cdd:PLN02843 21 VYKRVSDRNNGE-SFTLHDGPPYANGDLHIGHALNKILKDFINRYQLLQGKKVHYVPGWDCHGLPIELKVLQSldQEARK 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 144 --SSLEIRKIAKDFANSAVQEQLMMFQRMAVMGDWPSRYITMSDKFEIAELKVFLSLLQKDLIFRQNKPVYWSSSSRSAL 221
Cdd:PLN02843 100 elTPIKLRAKAAKFAKKTVDTQRESFKRYGVWGDWENPYLTLDPEYEAAQIEVFGQMFLNGYIYRGRKPVHWSPSSRTAL 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 222 AESEIEYDDNHVSTSIYFTFPVNSFSIDGCE-----YNNVKALVWTTTPWTIPSNLALSYHPEINY-------------- 282
Cdd:PLN02843 180 AEAELEYPEGHVSKSIYVAFPVVSPSETSPEeleefLPGLSLAIWTTTPWTMPANAAVAVNDKLQYsvvevqsfsedest 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 283 -----------GLYQHNNSIYLMSDNLVPNLDFMQGAKR--LASCPSDIISSFTYENPLLPKQSFPFLQSNYVTNDIGTG 349
Cdd:PLN02843 260 sggnkkkrpgnVLKEQQKLFLIVATDLVPALEAKWGVKLvvLKTFPGSDLEGCRYIHPLYNRESPVVIGGDYITTESGTG 339
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 350 IVHVAPGHGMEDYLLGLENNLRPFSPLDDYGRYTKEAldGSLEGLEVLGDGGKKVISIMKNQNMIVKVSPYKHRYPYDWR 429
Cdd:PLN02843 340 LVHTAPGHGQEDYITGLKYGLPLLSPVDDAGKFTEEA--GQFSGLSVLGEGNAAVVEALDEAGSLLMEEAYGHKYPYDWR 417
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 430 THKPLILRATPQWFISLENERKTAIKALDSVKMIPPNSRARLLGFLNGRPEWCISRQRAWGLPIPVLYEKGTKIPLLTVK 509
Cdd:PLN02843 418 TKKPTIFRATEQWFASVEGFRQAALDAIDKVKWIPAQGENRIRAMVSGRSDWCISRQRTWGVPIPVFYHVETKEPLMNEE 497
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 510 SVSYIIEKMEVEGVDSWFN-DTEnnghaQWVHPDYRNK--EYIRGTETLDVWFDSGTSWTTIAPRKNKPLI--DLCLEGS 584
Cdd:PLN02843 498 TIAHVKSIVAQKGSDAWWYmDVE-----DLLPEKYRDKasDYEKGTDTMDVWFDSGSSWAGVLGSREGLSYpaDLYLEGS 572
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 585 DQHRGWFQSLLLTYTAYQSKpeAPFSTLFTHGFIFDERGQKQSKSLGNVTDPEDVINGKLLKGKKLPYGVDLLRLWVASC 664
Cdd:PLN02843 573 DQHRGWFQSSLLTSVATKGK--APYKSVLTHGFVLDEKGFKMSKSLGNVVDPRLVIEGGKNQKQEPAYGADVLRLWVASV 650
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 665 DSTNDTNLGPNILTQVGESLKKWRLTSRFCLGNLHDWNTSSSVDVGELRGIDKLALVQLDKFQTEIRELYESYSINKVVH 744
Cdd:PLN02843 651 DYTGDVLIGPQILKQMSDIYRKLRGTLRYLLGNLHDWKPDNAVPYEDLPSIDKYALFQLENVVNEIEESYDNYQFFKIFQ 730
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 745 HLNYFMNSFLSSTYFDAVKDRLYADLPNSVSRRSVQTVLYHSLLTLIWAISPITPLLAQEIWQSLPDSYLNSSYQTPFHA 824
Cdd:PLN02843 731 ILQRFTIVDLSNFYLDVAKDRLYVGGTTSFTRRSCQTVLAAHLLSLLRAIAPILPHLAEDAWQNLPFQEDGSAAESVFEA 810
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 825 GETHLISSLRSkVDLLDRKFlikeYLVLQQLKYSINLLITAARENLTIKNSLEAYVVIKSKSQSLLSFL------KNYSS 898
Cdd:PLN02843 811 GWPTPNEEWLS-FPAEDVDF----WSLLLEVRDEVNKVLESARNGKLIGASLEAKVYLHASDASLAARLaelcgaSNGAD 885
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 899 DLPFLFNTSKVFINEIPENLKLASVTQPEVQLDyGVANISLFFSNQ--QKCLRCWMHTA-------HEDgLCDRCESVLA 969
Cdd:PLN02843 886 ELRRIFITSQVEVVSSEDDETAACGSYTGEYVE-GAGRVWVGVSRAdgSKCERCWNYSPavgsfsdHPT-LCERCYPVVI 963
|
...
gi 5701963 970 QLK 972
Cdd:PLN02843 964 AQP 966
|
|
| ileS |
TIGR00392 |
isoleucyl-tRNA synthetase; The isoleucyl tRNA synthetase (IleS) is a class I amino acyl-tRNA ... |
44-880 |
0e+00 |
|
isoleucyl-tRNA synthetase; The isoleucyl tRNA synthetase (IleS) is a class I amino acyl-tRNA ligase and is particularly closely related to the valyl tRNA synthetase. This model may recognize IleS from every species, including eukaryotic cytosolic and mitochondrial forms. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273054 [Multi-domain] Cd Length: 861 Bit Score: 724.16 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 44 SFPIKPNVKGNNEKYFKSITS-DLYEWQKENLNKEDSFVLLDGPPFANGRLHIGHALNKILKDIINRWQLLKGRSVHYVP 122
Cdd:TIGR00392 1 KFPMRGNLSKREEKILAFWQEnDIFEKVKKLNKGKPEFIFHDGPPYANGSIHLGHALNKILKDIILRYKTMQGFNVTRKP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 123 GWDCHGLPIESKAIK-------ANAERKSSLEIRKIAKDFANSAVQEQLMMFQRMAVMGDWPSRYITMSDKFEIAELKVF 195
Cdd:TIGR00392 81 GWDTHGLPIEHKVEKklgisgkKEISSLEIEEFREKCREFALKQIEEQREQFQRLGVWGDWENPYKTMDPSYEESQWWLF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 196 LSLLQKDLIFRQNKPVYWSSSSRSALAESEIEYDDN---HVSTSIYFTFPVnsfSIDGCEYNNVKA---LVWTTTPWTIP 269
Cdd:TIGR00392 161 KEAHEKGLLYRGLKPVYWSPRCRTALAEAEVEYKENykdVKDPSIYVKFPV---KKDKKTYLKVKLsslLIWTTTPWTLP 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 270 SNLALSYHPEINYGLYQHNN--SIYLMSDNLVPNLdfmqgAKRLAScPSDIISSF--------TYENPL------LPKQS 333
Cdd:TIGR00392 238 SNLAIAVHPDFEYALVQDNTkvEYFILAKKLVEKL-----YNKAGS-DYEIIKTFkgsdleglEYEHPLydfvsqLKEGA 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 334 FPFLQSNYVTNDIGTGIVHVAPGHGMEDYLLGLENNLRPFSPLDDYGRYTKEALDGS-----LEGLEVLgDGGKKVISIM 408
Cdd:TIGR00392 312 PVVIGGDHVTTEDGTGIVHTAPGHGEEDYEIGKKYGLEVLSPVDEKGVYTEGVNDFQgrfvkDADKDII-KANKIIIEQL 390
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 409 KNQNMIVKVSPYKHRYPYDWRTHKPLILRATPQWFISLENERKTAIKALDSVKMIPPNSRARLLGFLNGRPEWCISRQRA 488
Cdd:TIGR00392 391 KDKGLLLKAEKITHSYPHCWRTKTPVIYRATEQWFIKTKDIKDQMLEQIKKVNWVPEWGEGRFGNWLENRPDWCISRQRY 470
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 489 WGLPIPVLY-EKGTKipLLTVKSVSYIIEKMEVEGVDSWFNDTenngHAQWVHPDYRNK----EYIRGTETLDVWFDSGT 563
Cdd:TIGR00392 471 WGIPIPIWYcEDTGE--PIVVGSIEELIELIELKGIDAWFEDL----HRDFLDKITLKSgdggEYRRVPDVLDVWFDSGS 544
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 564 SWTTIA-------PRKNKPLIDLCLEGSDQHRGWFQSLLLTYTAyqSKPEAPFSTLFTHGFIFDERGQKQSKSLGNVTDP 636
Cdd:TIGR00392 545 MPYASIhypfeneKFKEVFPADFILEGSDQTRGWFYSSLAIGTA--LFGQAPYKNVITHGFTLDEKGRKMSKSLGNVVDP 622
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 637 EDVINgkllkgkklPYGVDLLRLWVASCDSTNDTNLGPNILTQVGESLKKWRL-TSRFCL--GNLHDWNTS-SSVDVGEL 712
Cdd:TIGR00392 623 LKVIN---------KYGADILRLYVASSDPWEDLRFSDEILKQVVEKYRKIRWnTYRFLLtyANLDKFDPLfNSVAVEKF 693
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 713 RGIDKLALVQLDKFQTEIRELYESYSINKVVHHLNYFMNSFLSSTYFDAVKDRLYADLPNSvSRRSVQTVLYHSLLTLIW 792
Cdd:TIGR00392 694 PEEDRWILSRLNSLVEEVNEALEKYNFHKVLRALQDFIVEELSNWYIRIIRDRLYCEAKDN-DKRAAQTTLYYALLTLVR 772
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 793 AISPITPLLAQEIWQSLPDSYLNSS-YQTPFHAGETHLISS-LRSKVDLLDRKFlikeyLVLQQLKYSINLLITAARENL 870
Cdd:TIGR00392 773 LLAPFLPHTAEEIYQNLPGGEEEESvHLNLWPEVDEEFIDEaLEANMAIVREIV-----EAFLALRDAANKKLRQPLKEL 847
|
890
....*....|
gi 5701963 871 TIKNSLEAYV 880
Cdd:TIGR00392 848 VIGKSLEAVL 857
|
|
| tRNA-synt_1 |
pfam00133 |
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too ... |
64-672 |
1.08e-170 |
|
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too dissimilar to be included.
Pssm-ID: 459685 [Multi-domain] Cd Length: 602 Bit Score: 511.19 E-value: 1.08e-170
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 64 SDLYEWQKENLNKEDSFVLLDGPPFANGRLHIGHALNKILKDIINRWQLLKGRSVHYVPGWDCHGLPIESK-----AIKA 138
Cdd:pfam00133 9 QGYFKPELEKRKGKPSFTIHDGPPNATGSLHIGHALAKTLKDIVIRYKRMKGYYVLWVPGWDHHGLPTEQVvekklGIKE 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 139 NAERK--SSLEIRKIAKDFANSAVQEQLMMFQRMAVMGDWPSRYITMSDKFEIAELKVFLSLLQKDLIFRQNKPVYWSSS 216
Cdd:pfam00133 89 KKTRHkyGREEFREKCREWKMEYADEIRKQFRRLGRSIDWDREYFTMDPELEAAVWEVFVRLHDKGLIYRGKKLVNWSPA 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 217 SRSALAESEIEYDDNHvSTSIYFTFPVnsfsIDGCEynnVKALVWTTTPWTIPSNLALSYHPEINYGLyqhNNSIYLMSD 296
Cdd:pfam00133 169 LNTALSNLEVEYKDVK-GPSIHVAFPL----ADDEG---ASLVIWTTTPWTLPGNTAVAVNPEFDYVI---TGEGYILAE 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 297 NLVPNLDFMQGAKRLASCP--SDIISSFtYENPLLPKQsFPFLQSNYVTNDIGTGIVHVAPGHGMEDYLLGLENNLRPFS 374
Cdd:pfam00133 238 ALLKSLYKKGTDKKILEDFrgKELEGKE-AIHPFVNRE-IPIITDDYVDMEFGTGAVHIAPAHGENDYEVGQRHNLEVIN 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 375 PLDDYGRYTKEALDgsLEGLEVLgDGGKKVISIMKNQNMIVKVSPYKHRYPYDWRTHKPLILRATPQWFISLENERKTAI 454
Cdd:pfam00133 316 PVDDDGTFTEEAPD--FQGVYRF-DARKKIVELLTEKGLLLKIEPFTHSYPFCWRSGTPIIPRATPQWFVRMDELADQAL 392
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 455 KALDSVKMIPPNSRARLLGFLNGRPEWCISRQRAWGLPIPVLYEKGTKIPLLTVKSVSYIIEKMEVEGVDSWFNDTENNg 534
Cdd:pfam00133 393 EAVEKVQFVPKSGEKRYFNWLANIQDWCISRQRWWGHPIPAWVSKDTEEVVCRGELFELVAGRFEEEGSIKWLHREAKD- 471
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 535 haqwvHPDYRNKEYIRGTETLDVWFDSGtSW---TTIAPRKNKPLI------DLCLEGSDQHRGWFQSLLLTYTAYqsKP 605
Cdd:pfam00133 472 -----KLGYGKGTLEQDEDVLDTWFSSG-SWpfsTLGWPFVNTEEFkkffpaDMLLEGSDQTRGWFYRMIMLSTAL--TG 543
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 5701963 606 EAPFSTLFTHGFIFDERGQKQSKSLGNVTDPEDVINgkllkgkklPYGVDLLRLWVASCDSTNDTNL 672
Cdd:pfam00133 544 SVPFKNVLVHGLVRDEQGRKMSKSLGNVIDPLDVID---------KYGADALRLWLANSDYGRDINL 601
|
|
| valS |
TIGR00422 |
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase ... |
56-930 |
7.47e-104 |
|
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase and is particularly closely related to the isoleucyl tRNA synthetase. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273070 [Multi-domain] Cd Length: 861 Bit Score: 343.96 E-value: 7.47e-104
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 56 EKY-FKSITSDLYE-WQKENLNKED------SFVLLDGPPFANGRLHIGHALNKILKDIINRWQLLKGRSVHYVPGWDCH 127
Cdd:TIGR00422 3 KDYdPHEVEKKWYKkWEKSGFFKPDgnsnkpPFCIDIPPPNVTGSLHIGHALNWSIQDIIARYKRMKGYNVLWLPGTDHA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 128 GLPIESKAIK-ANAERKSSLE------IRKIA--KDFANSAVQEQLmmfQRMAVMGDWPSRYITMSDKFEIAELKVFLSL 198
Cdd:TIGR00422 83 GIATQVKVEKkLGAEGKTKHDlgreefREKIWewKEESGGTIKNQI---KRLGASLDWSRERFTMDEGLSKAVKEAFVRL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 199 LQKDLIFRQNKPVYWSSSSRSALAESEIEYDDnhVSTSI-YFTFPVNSFSIDgceynnvKALVWTTTPWTIPSNLALSYH 277
Cdd:TIGR00422 160 YEKGLIYRGEYLVNWDPKLNTAISDIEVEYKE--VKGKLyYIRYPLANGSKD-------YLVVATTRPETMFGDTAVAVH 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 278 PEINYglYQHnnsiylMSDNLVpnldfmqgakrlascpsdiissftyENPLLPKQsFPFLQSNYVTNDIGTGIVHVAPGH 357
Cdd:TIGR00422 231 PEDER--YKH------LIGKKV-------------------------ILPLTGRK-IPIIADEYVDMEFGTGAVKVTPAH 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 358 GMEDYLLGLENNLRPFSPLDDYGRYTKEALDgsLEGLEVLgDGGKKVISIMKNQNMIVKVSPYKHRYPYDWRTHKPLILR 437
Cdd:TIGR00422 277 DFNDYEWGKRHNLEFINILDEDGLLNENAGK--YQGLTRF-EARKKIVEDLKEEGLLVKIEPHTHNVGTCWRSGTVVEPL 353
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 438 ATPQWFISLENERKTAIKALD--SVKMIPPNSRARLLGFLNGRPEWCISRQRAWGLPIPVLYEKgtkiplltvKSVSYII 515
Cdd:TIGR00422 354 LSKQWFVKVEKLADKALEAAEegEIKFVPKRMEKRYLNWLRNIKDWCISRQLIWGHRIPVWYCK---------ECGEVYV 424
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 516 EKMEVEGVDswfndtENNghaqwvhpDYRNKEYIRGTETLDVWFDSGTsWTTIA---PRKNKPL-----IDLCLEGSDQH 587
Cdd:TIGR00422 425 AKEEPLPDD------KTN--------TGPSVELEQDTDVLDTWFSSSL-WPFSTlgwPDETKDLkkfypTDLLVTGYDII 489
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 588 RGW-----FQSLLLTytayqskPEAPFSTLFTHGFIFDERGQKQSKSLGNVTDPEDVINgkllkgkklPYGVDLLRLWVA 662
Cdd:TIGR00422 490 FFWvarmiFRSLALT-------GQVPFKEVYIHGLVRDEQGRKMSKSLGNVIDPLDVIE---------KYGADALRFTLA 553
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 663 SCDSTNDTnlgPNILTQVGESLKK-----WRlTSRFCLGNLHDWNTSSSvDVGELRGIDKLALVQLDKFQTEIRELYESY 737
Cdd:TIGR00422 554 SLVTPGDD---INFDWKRVESARNflnklWN-ASRFVLMNLSDDLELSG-GEEKLSLADRWILSKLNRTIKEVRKALDKY 628
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 738 SINKVVHHL-NYFMNSFlSSTYFDAVKDRLYADlpNSVSRRSVQTVLYHSLLTLIWAISPITPLLAQEIWQSLP---DSY 813
Cdd:TIGR00422 629 RFAEAAKALyEFIWNDF-CDWYIELVKYRLYNG--NEAEKKAARDTLYYVLDKALRLLHPFMPFITEEIWQHFKegaDSI 705
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 814 LNSSYqtPfhageTHLISSLRSKvdlLDRKF-LIKEYLV-LQQLKYSINLLITAAREnltiknsleayVVIKSKSQSLLS 891
Cdd:TIGR00422 706 MLQSY--P-----VVDAEFVDEE---AEKAFeLLKEIIVsIRNLKAESNIPPNAPLK-----------VLLIYTEAETAE 764
|
890 900 910 920
....*....|....*....|....*....|....*....|
gi 5701963 892 FLKNYSSDLPFLFNTSKVFIN-EIPENLKLASVTQPEVQL 930
Cdd:TIGR00422 765 RLKLNAVDIKGAINFSEVEVViEKPEVTEAVVELVPGFEI 804
|
|
| IleRS_core |
cd00818 |
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases ... |
78-666 |
1.49e-93 |
|
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases (IleRS) catalytic core domain . This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. IleRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173909 [Multi-domain] Cd Length: 338 Bit Score: 299.92 E-value: 1.49e-93
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 78 DSFVLLDGPPFANGRLHIGHALNKILKDIINRWQLLKGRSVHYVPGWDCHGLPIESKAIKANA-------ERKSSLEIRK 150
Cdd:cd00818 1 PEFVFHDGPPYANGLPHYGHALNKILKDIINRYKTMQGYYVPRRPGWDCHGLPIELKVEKELGisgkkdiEKMGIAEFNA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 151 IAKDFANSAVQEQLMMFQRMAVMGDWPSRYITMSDKFEIAELKVFLSLLQKDLIFRQNKPVYWssssrsalaeseieydd 230
Cdd:cd00818 81 KCREFALRYVDEQEEQFQRLGVWVDWENPYKTMDPEYMESVWWVFKQLHEKGLLYRGYKVVPW----------------- 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 231 nhvstsiyftfpvnsfsidgceynnvkALVWTTTP-WTIpsnlalsyhpeinyglyqhnnSIYLMSDNLVPNLDfmqgak 309
Cdd:cd00818 144 ---------------------------PLIYRATPqWFI---------------------RVTKIKDRLLEAND------ 169
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 310 rlascpsdiissftyenpllpkqsfpflQSNYVtndigtgivhvaPGHGmedyllglennlrpfsplddygrytkealdg 389
Cdd:cd00818 170 ----------------------------KVNWI------------PEWV------------------------------- 178
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 390 sleglevlgdggkkvisimknqnmivkvspyKHRYpYDWrthkpliLRATPQWFIslenerktaikaldsvkmippnSRA 469
Cdd:cd00818 179 -------------------------------KNRF-GNW-------LENRRDWCI----------------------SRQ 197
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 470 RllgflngrpewcisrqrAWGLPIPVLYEKGTKIPLLTvksvsyiiekmevegvdswfndtennghaqwvhpdyrnkeyi 549
Cdd:cd00818 198 R-----------------YWGTPIPVWYCEDCGEVLVR------------------------------------------ 218
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 550 RGTETLDVWFDSGTSWTTIAPRK-------NKPLIDLCLEGSDQHRGWFQSLLLTYTAYQSKpeAPFSTLFTHGFIFDER 622
Cdd:cd00818 219 RVPDVLDVWFDSGSMPYAQLHYPfenedfeELFPADFILEGSDQTRGWFYSLLLLSTALFGK--APYKNVIVHGFVLDED 296
|
570 580 590 600
....*....|....*....|....*....|....*....|....
gi 5701963 623 GQKQSKSLGNVTDPEDVINgkllkgkklPYGVDLLRLWVASCDS 666
Cdd:cd00818 297 GRKMSKSLGNYVDPQEVVD---------KYGADALRLWVASSDV 331
|
|
| PLN02882 |
PLN02882 |
aminoacyl-tRNA ligase |
69-809 |
1.48e-81 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215477 [Multi-domain] Cd Length: 1159 Bit Score: 287.39 E-value: 1.48e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 69 WQKENLNKE--------DSFVLLDGPPFANGRLHIGHALNKILKDIINRWQLLKGRSVHYVPGWDCHGLPIESKaI--KA 138
Cdd:PLN02882 21 WSEIDAFKTqlkrteglPEYIFYDGPPFATGLPHYGHILAGTIKDIVTRYQSMTGHHVTRRFGWDCHGLPVEYE-IdkKL 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 139 NAERKSslEIRKIAKDFANSA--------VQEQLMMFQRMAVMGDWPSRYITMSDKFEIAELKVFLSLLQKDLIFRQNKP 210
Cdd:PLN02882 100 GIKRRD--DVLKMGIDKYNEEcrsivtrySKEWEKTVTRTGRWIDFENDYKTMDPKFMESVWWVFKQLFEKGLVYKGFKV 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 211 VYWSSSSRSALA--ESEIEYDDNHvSTSIYFTFPvnsfsIDGCEYNnvKALV-WTTTPWTIPSNLALSYHPEINYG--LY 285
Cdd:PLN02882 178 MPYSTACKTPLSnfEAGLNYKDVS-DPAVMVSFP-----IVGDPDN--ASFVaWTTTPWTLPSNLALCVNPNFTYVkvRN 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 286 QHNNSIYLMSDNLVPNL--------------DFMQGAKRLASCPSDIISSFTYEnPLLP------KQSFPFLQSNYVTND 345
Cdd:PLN02882 250 KYTGKVYIVAESRLSALptakpkskkgskpeNAAEGYEVLAKVPGSSLVGKKYE-PLFDyfsefsDTAFRVVADDYVTDD 328
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 346 IGTGIVHVAPGHGMEDYLLGLENNL------RPfSPLDDYGRYTKEALDGSleGLEVlGDGGKKVISIMKNQNMIVKVSP 419
Cdd:PLN02882 329 SGTGVVHCAPAFGEDDYRVCLANGIiekggnLP-VPVDDDGCFTEKVTDFS--GRYV-KDADKDIIAAIKAKGRLVKSGS 404
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 420 YKHRYPYDWRTHKPLILRATPQWFISLENERKTAIKALDSVKMIPPNSR-ARLLGFLNGRPEWCISRQRAWGLPIPV-LY 497
Cdd:PLN02882 405 ITHSYPFCWRSDTPLIYRAVPSWFVKVEEIKDRLLENNKQTYWVPDYVKeKRFHNWLENARDWAVSRSRFWGTPLPIwIS 484
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 498 EKGTKIplLTVKSVSYiIEKMEVEGVDswfnDTENNGHAQWVHPDYRNKEY---IRGTETLDVWFDSGT-SWTTIA-PRK 572
Cdd:PLN02882 485 DDGEEV--VVIGSIAE-LEKLSGVKVT----DLHRHFIDHITIPSSRGPEFgvlRRVDDVFDCWFESGSmPYAYIHyPFE 557
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 573 NKPL------IDLCLEGSDQHRGWFQSLLLTYTAYQSKPeaPFSTLFTHGFIFDERGQKQSKSLGNVTDPEDVINgkllk 646
Cdd:PLN02882 558 NKELfeknfpADFVAEGLDQTRGWFYTLMVLSTALFDKP--AFKNLICNGLVLAEDGKKMSKSLKNYPDPNEVID----- 630
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 647 gkklPYGVDLLRLW-----VASCDSTNDTNLGpnILTQVGESLKKWRLTSRFCLGNLHDWNTSSS-----VDVGELRG-- 714
Cdd:PLN02882 631 ----KYGADALRLYlinspVVRAEPLRFKEEG--VFGVVKDVFLPWYNAYRFLVQNAKRLEVEGGapfvpLDLAKLQNsa 704
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 715 --IDKLALVQLDKFQTEIRELYESYSINKVVHHLNYFMNSfLSSTYFDAVKDRLYADLPNSVSRRSVQTvLYHSLLTLIW 792
Cdd:PLN02882 705 nvLDRWINSATQSLVKFVREEMGAYRLYTVVPYLVKFIDN-LTNIYVRFNRKRLKGRTGEEDCRTALST-LYNVLLTSCK 782
|
810
....*....|....*..
gi 5701963 793 AISPITPLLAQEIWQSL 809
Cdd:PLN02882 783 VMAPFTPFFTEVLYQNL 799
|
|
| valS |
PRK13208 |
valyl-tRNA synthetase; Reviewed |
45-812 |
9.36e-77 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 237306 [Multi-domain] Cd Length: 800 Bit Score: 268.21 E-value: 9.36e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 45 FPIKPNVKGNNEKYFKS-ITSDLYEWQKENlnKEDSFVLLDGPPFANGRLHIGHALNKILKDIINRWQLLKGRSVHYVPG 123
Cdd:PRK13208 6 LPKKYDPEELEEKWQKIwEEEGTYKFDPDE--RKPVYSIDTPPPTVSGSLHIGHVFSYTHTDFIARYQRMRGYNVFFPQG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 124 WDCHGLPIESKA-----IKAN-AERKsslEIRKIAKDFANSAVQEQLMMFQRMAVMGDWPSRYITMSDK-FEIAElKVFL 196
Cdd:PRK13208 84 WDDNGLPTERKVekyygIRKDdISRE---EFIELCRELTDEDEKKFRELWRRLGLSVDWSLEYQTISPEyRRISQ-KSFL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 197 SLLQKDLIFRQNKPVYWSSSSRSALAESEIEYDDNHvSTSIYFTFPVNSfsidgceynNVKALVWTTTPWTIPSNLALSY 276
Cdd:PRK13208 160 DLYKKGLIYRAEAPVLWCPRCETAIAQAEVEYRERE-GKLNYIKFPVED---------GEEIEIATTRPELLPACVAVVV 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 277 HPEINYglYQHnnsiylmsdnlvpnldfMQGAKrlASCPsdiisSFTYENPLLPKQSfpflqsnyVTNDIGTGIVhvapg 356
Cdd:PRK13208 230 HPDDER--YKH-----------------LVGKT--AIVP-----LFGVEVPILADPL--------VDPDFGTGAV----- 270
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 357 hgM-------EDYLLGLENNLRPFSPLDDYGRYTKEAldGSLEGLEVLgDGGKKVISIMKNQNMIVKVSPYKHRYPYDWR 429
Cdd:PRK13208 271 --MictfgdkTDVTWWRELNLPTRIIIDEDGRMTEAA--GKLAGLTIE-EARKKIVEDLKSGGLLGKQEPIKHNVKFCER 345
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 430 THKPLILRATPQWFISLENERKTAIKALDSVKMIPPNSRARLLGFLNG-RPEWCISRQRAWGLPIPVLY-EKGTKIpllt 507
Cdd:PRK13208 346 CDTPLEILVTRQWFIKVLDLKEELLERGKEINWYPEHMRVRLENWIEGlNWDWCISRQRYFGTPIPVWYcKDCGHP---- 421
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 508 vksvsyIIEKMEVEGVDSWFNDtennghAQWVHPDYRNKEYIRG-TETLDVWFDSG------TSWTTIAPRKNK--PLiD 578
Cdd:PRK13208 422 ------ILPDEEDLPVDPTKDE------PPGYKCPQCGSPGFEGeTDVMDTWATSSitplivTGWERDEDLFEKvfPM-D 488
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 579 LCLEGSDQHRGWfqsllLTYT---AYQSKPEAPFSTLFTHGFIFDERGQKQSKSLGNVTDPEDVINgkllkgkklPYGVD 655
Cdd:PRK13208 489 LRPQGHDIIRTW-----LFYTilrAYLLTGKLPWKNIMISGMVLDPDGKKMSKSKGNVVTPEELLE---------KYGAD 554
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 656 LLRLWVASCDSTNDTNLGPNILtQVGESL--KKWRLtSRFCLgNLHDWNTSSSVDVgeLRGIDKLALVQLDKFQTEIREL 733
Cdd:PRK13208 555 AVRYWAASARLGSDTPFDEKQV-KIGRRLltKLWNA-SRFVL-HFSADPEPDKAEV--LEPLDRWILAKLAKVVEKATEA 629
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 734 YESYSINKVVHHL-NYFMNSFlSSTYFDAVKDRLYADlPNSVSRRSVQTVLYHSLLTLIWAISPITPLLAQEIWQSLPDS 812
Cdd:PRK13208 630 LENYDFAKALEEIeSFFWHVF-CDDYLELVKSRAYGE-DEEEEQKSARYTLYTVLDTLLRLLAPFLPFITEEVWSWLYGG 707
|
|
| PTZ00427 |
PTZ00427 |
isoleucine-tRNA ligase, putative; Provisional |
49-809 |
3.79e-64 |
|
isoleucine-tRNA ligase, putative; Provisional
Pssm-ID: 173617 [Multi-domain] Cd Length: 1205 Bit Score: 236.40 E-value: 3.79e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 49 PNVKGNNEK---YFKSItsDLYEWQKENLNKEDSFVLLDGPPFANGRLHIGHALNKILKDIINRWQLLKGRSVHYVPGWD 125
Cdd:PTZ00427 72 PNIVEEEEKvlkYWKSI--DAFNTSNKLAKNKKAYIFYDGPPFATGLPHYGHLLAGIIKDCVTRYFYQCGFSVERKFGWD 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 126 CHGLPIESKAIKANAERKSSlEIRKIAKDFANSAVQ--------EQLMMFQRMAVMGDWPSRYITMSDKFEIAELKVFLS 197
Cdd:PTZ00427 150 CHGLPIEYEIEKENNINKKE-DILKMGIDVYNEKCRgivlkysnEWVKTVERIGRWIDFKNDYKTMDKTFMESVWWVFSE 228
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 198 LLQKDLIFRQNKPVYWSSSSRSALAESEIE--YDDNH-----VSTSIYFTFP---------------VNSFSI------- 248
Cdd:PTZ00427 229 LYKNNYVYKSFKVMPYSCKCNTPISNFELNlnYKDTPdpsiiISFVLCSDFPkveeecnieedkqllGEKYSVlynnkre 308
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 249 DGCEYNN-----------VKALVWTTTPWTIPSNLALSYHPEINYGLYQH--NNSIYLMSDNL-----------VPNLDF 304
Cdd:PTZ00427 309 NSNNGNNnstnnvcyaqhSEILAWTTTPWTLPSNLALCVNEHFTYLRIHHvkSNRVVIVGECRlewimkelkwnVEDLKI 388
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 305 MQ--GAKRLASCPSDIISSFTYENPLLPKQSFPFLQSNYVTNDIGTGIVHVAPGHGMEDYLLGLENN-LRP-----FSPL 376
Cdd:PTZ00427 389 VNrfKGKELKGLRYKPLFTNFYEKYNFKERAYKILADDFVTDDAGTGIVHCAPTYGEDDFRVCKKNGvIDPeknifIDPL 468
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 377 DDYGRYTKEaldgsLEGLEVL--GDGGKKVISIMKNQNMIVKVSPYKHRYPYDWRTHKPLILRATPQWFISLENERKTAI 454
Cdd:PTZ00427 469 DANGYFTNE-----VEEVQNLyiKEADNVIKKKLKNENRLLSNNTIVHSYPFCWRSDTPLIYRAIPAWFIRVSNSTNELV 543
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 455 KALDSVKMIPPNSRARLL-GFLNGRPEWCISRQRAWGLPIPVLYEKGTKIpLLTVKSVSYIIEKMEVEGVdswfndteNN 533
Cdd:PTZ00427 544 KNNETTYWIPAHIKEKKFhNWIKDAKDWCISRNRYWGTPIPIWADEKMET-VICVESIKHLEELSGVKNI--------ND 614
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 534 GHAQWV-HPDYRN---KEY---IRGTETLDVWFDSGT--------SWTTIAPRKNKPL-IDLCLEGSDQHRGWFQSLLLT 597
Cdd:PTZ00427 615 LHRHFIdHIEIKNpkgKTYpklKRIPEVFDCWFESGSmpyakvhyPFSTEKEDFHKIFpADFIAEGLDQTRGWFYTLLVI 694
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 598 YTAYQSKpeAPFSTLFTHGFIFDERGQKQSKSLGNVTDPEDVINgkllkgkklPYGVDLLRLWVASCDSTNDTNLGPNiL 677
Cdd:PTZ00427 695 STLLFDK--APFKNLICNGLVLASDGKKMSKRLKNYPDPLYILD---------KYGADSLRLYLINSVAVRAENLKFQ-E 762
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 678 TQVGESLKKWRL----TSRF---------CLGNLH-----DWNTSSSvdvgelRGIDKLALVQLDKFQTEIRELYESYSI 739
Cdd:PTZ00427 763 KGVNEVVKSFILpfyhSFRFfsqevtryeCLNKKQflfntDYIYKND------NIMDQWIFSSVQSLTKSVHTEMKAYKL 836
|
810 820 830 840 850 860 870
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 740 NKVVHHLNYFMNSfLSSTYFDAVKDRLYADLPNSVSRRSVQTvLYHSLLTLIWAISPITPLLAQEIWQSL 809
Cdd:PTZ00427 837 YNVLPKLLQFIEN-LTNWYIRLNRDRMRGSLGEENCLQSLCT-TYRTLHLFTVLMAPFTPFITEYIYQQL 904
|
|
| valS |
PRK14900 |
valyl-tRNA synthetase; Provisional |
80-826 |
2.08e-61 |
|
valyl-tRNA synthetase; Provisional
Pssm-ID: 237855 [Multi-domain] Cd Length: 1052 Bit Score: 227.18 E-value: 2.08e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 80 FVLLDGPPFANGRLHIGHALNKILKDIINRWQLLKGRSVHYVPGWDCHGLP---IESKAIKaNAERKSSLEIRKIA---- 152
Cdd:PRK14900 50 FSIVLPPPNVTGSLHLGHALTATLQDVLIRWKRMSGFNTLWLPGTDHAGIAtqmIVEKELK-KTEKKSRHDLGREAfler 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 153 ----KDFANSAVQEQlmmFQRMAVMGDWPSRYITMSDKFEIAELKVFLSLLQKDLIFRQNKPVYWSSSSRSALAESEIEY 228
Cdd:PRK14900 129 vwawKEQYGSRIGEQ---HKALGASLDWQRERFTMDEGLSRAVREVFVRLHEEGLIYREKKLINWCPDCRTALSDLEVEH 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 229 DDNHVSTSIYFTFPVnsfsIDGceynNVKALVWTTTPWTIPSNLALSYHPEInyglyqhnnsiylmsdnlvPNLDFMQGA 308
Cdd:PRK14900 206 EEAHQGELWSFAYPL----ADG----SGEIVVATTRPETMLGDTAVAVHPLD-------------------PRYMALHGK 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 309 KrlascpsdiissftYENPLLPKQsFPFL-QSNYVTNDIGTGIVHVAPGHGMEDYLLGLENNLRPFSPLDDYGRYTKEAl 387
Cdd:PRK14900 259 K--------------VRHPITGRT-FPIVaDAILVDPKFGTGAVKVTPAHDFNDFEVGKRHGLEMITVIGPDGRMTAEA- 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 388 dGSLEGLEVLgDGGKKVISIMKNQNMIVKVSPYKHRYPYDWRTHKPLILRATPQWFISLENERKTAIKALDS--VKMIPP 465
Cdd:PRK14900 323 -GPLAGLDRF-EARKEVKRLLAEQGLDRGAKPHVLPLGRCQRSATILEPLLSDQWYVRIEPLARPAIEAVEQgrTRFIPE 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 466 NSRARLLGFLNGRPEWCISRQRAWGLPIPVLYEKGTKIplltvksvsyIIEKMEVEGVdswfndtennghaqwvhPDYRN 545
Cdd:PRK14900 401 QWTNTYMAWMRNIHDWCISRQLWWGHQIPAWYCPDGHV----------TVARETPEAC-----------------STCGK 453
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 546 KEYIRGTETLDVWFDSGT-SWTTIAPRKNKPLIDLCLEGSDQHRG------WFQSLLLTYTAYQSkpEAPFSTLFTHGFI 618
Cdd:PRK14900 454 AELRQDEDVLDTWFSSGLwPFSTMGWPEQTDTLRTFYPTSVMETGhdiiffWVARMMMMGLHFMG--EVPFRTVYLHPMV 531
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 619 FDERGQKQSKSLGNVTDPEDVINGkllkgkklpYGVDLLRLWVAScdstndtnlgpniLTQVGESLK--KWRL------- 689
Cdd:PRK14900 532 RDEKGQKMSKTKGNVIDPLVITEQ---------YGADALRFTLAA-------------LTAQGRDIKlaKERIegyrafa 589
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 690 -----TSRFCLGNLHDWnTSSSVDVGE--LRGIDKLALVQLDKFQTEIRELYESYSINKVVHHLNYFMNSFLSSTYFDAV 762
Cdd:PRK14900 590 nklwnASRFALMNLSGY-QERGEDPARlaRTPADRWILARLQRAVNETVEALEAFRFNDAANAVYAFVWHELCDWYIELA 668
|
730 740 750 760 770 780 790
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 5701963 763 KDRLYADLPNsvSRRSVQTVLYHSLLTLIWAISPITPLLAQEIWQSLP---------DSYLNSSYQTPFHAGE 826
Cdd:PRK14900 669 KEALASEDPE--ARRSVQAVLVHCLQTSYRLLHPFMPFITEELWHVLRaqvgasawaDSVLAAEYPRKGEADE 739
|
|
| Anticodon_Ia_Ile_BEm |
cd07960 |
Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; ... |
672-860 |
3.30e-59 |
|
Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial and eukaryotic mitochondrial members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
Pssm-ID: 153414 [Multi-domain] Cd Length: 180 Bit Score: 200.44 E-value: 3.30e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 672 LGPNILTQVGESLKKWRLTSRFCLGNLHDWN-TSSSVDVGELRGIDKLALVQLDKFQTEIRELYESYSINKVVHHLNYFM 750
Cdd:cd07960 1 ISDEILKQVAEAYRKIRNTFRFLLGNLNDFDpAKDAVPYEELLELDRYALHRLNELIKEVREAYENYEFHKVYQALNNFC 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 751 NSFLSSTYFDAVKDRLYADLPNSVSRRSVQTVLYHSLLTLIWAISPITPLLAQEIWQSLPDSYLNSS-YQTPFHAGETHL 829
Cdd:cd07960 81 TVDLSAFYLDIIKDRLYCDAKDSLERRSAQTVLYHILDALLKLLAPILPFTAEEVWEHLPGEKKEESvFLEDWPELPEEW 160
|
170 180 190
....*....|....*....|....*....|.
gi 5701963 830 ISslrskvdlldrKFLIKEYLVLQQLKYSIN 860
Cdd:cd07960 161 KD-----------EELEEKWEKLLALRDEVN 180
|
|
| PLN02943 |
PLN02943 |
aminoacyl-tRNA ligase |
66-811 |
7.25e-54 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215509 [Multi-domain] Cd Length: 958 Bit Score: 203.63 E-value: 7.25e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 66 LYEWQ------KENLNK-EDSFVLLDGPPFANGRLHIGHALNKILKDIINRWQLLKGRSVHYVPGWDCHGLPIE---SKA 135
Cdd:PLN02943 69 IYNWWesqgyfKPNFDRgGDPFVIPMPPPNVTGSLHMGHAMFVTLEDIMVRYNRMKGRPTLWIPGTDHAGIATQlvvEKM 148
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 136 IKANAERKSSLEIRKIA------KDFANSAVQEQLmmfQRMAVMGDWPSRYITMSDKFEIAELKVFLSLLQKDLIFRQNK 209
Cdd:PLN02943 149 LASEGIKRTDLGRDEFTkrvwewKEKYGGTITNQI---KRLGASCDWSRERFTLDEQLSRAVVEAFVRLHEKGLIYQGSY 225
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 210 PVYWSSSSRSALAESEIEYDDNHvSTSIYFTFPVNSFSIDGCEynnvkalVWTTTPWTIPSNLALSYHPEinyglyQHNN 289
Cdd:PLN02943 226 MVNWSPNLQTAVSDLEVEYSEEP-GTLYYIKYRVAGGSEDFLT-------IATTRPETLFGDVAIAVNPE------DDRY 291
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 290 SIYLMSDNLVPnldfMQGAKRLascpsdiissftyenpllpkqsfPFLQSNYVTNDIGTGIVHVAPGHGMEDYLLGLENN 369
Cdd:PLN02943 292 SKYIGKMAIVP----MTYGRHV-----------------------PIIADRYVDKDFGTGVLKISPGHDHNDYLLARKLG 344
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 370 LrPFspLDDYGRytkealDGSLEglEVLG----DGGKKVISIMKNQNMIVKVSPYKHRYPYDWR---THKPLIlraTPQW 442
Cdd:PLN02943 345 L-PI--LNVMNK------DGTLN--EVAGlywfEAREKLWSDLEETGLAVKKEPHTLRVPRSQRggeVIEPLV---SKQW 410
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 443 FISLENERKTAIKALDSVKM-IPPNSRARLLGF-LNGRPEWCISRQRAWGLPIPVLYEKGTKIplltvkSVSYIIEKMEV 520
Cdd:PLN02943 411 FVTMEPLAEKALKAVENGELtIIPERFEKIYNHwLSNIKDWCISRQLWWGHRIPVWYIVGKDC------EEDYIVARSAE 484
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 521 EGVDSwfnDTENNGhaqwvhpdyRNKEYIRGTETLDVWFDSGT------SWTTIAPRKNKPLI-DLCLE-GSDQHRGWFQ 592
Cdd:PLN02943 485 EALEK---AREKYG---------KDVEIYQDPDVLDTWFSSALwpfstlGWPDVSAEDFKKFYpTTVLEtGHDILFFWVA 552
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 593 SLLLTYTAYQSKpeAPFSTLFTHGFIFDERGQKQSKSLGNVTDPEDVINgkllkgkklPYGVDLLRLWVASCDSTNDTNL 672
Cdd:PLN02943 553 RMVMMGIEFTGT--VPFSYVYLHGLIRDSQGRKMSKTLGNVIDPLDTIK---------EFGTDALRFTLALGTAGQDLNL 621
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 673 GPNILTQVGESLKKWRLTSRFCLGNLHDWNTSSSVDVGELRGIDKLALVQ------------LDKFQTEIRELYESYSIN 740
Cdd:PLN02943 622 STERLTSNKAFTNKLWNAGKFVLQNLPSQSDTSAWEHILACKFDKEESLLslplpecwvvskLHELIDSVTTSYDKYFFG 701
|
730 740 750 760 770 780 790
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 5701963 741 KVVHHLNYFMNSFLSSTYFDAVKDRLYADLPNSVSRRSvQTVLYHSLLTLIWAISPITPLLAQEIWQSLPD 811
Cdd:PLN02943 702 DVGREIYDFFWSDFADWYIEASKTRLYHSGDNSALSRA-QAVLLYVFENILKLLHPFMPFVTEELWQALPY 771
|
|
| valS |
PRK05729 |
valyl-tRNA synthetase; Reviewed |
57-925 |
3.33e-53 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 235582 [Multi-domain] Cd Length: 874 Bit Score: 200.72 E-value: 3.33e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 57 KY-FKSITSDLYE-WQKENL-----NKEDSFVLLDGPPFANGRLHIGHALNKILKDIINRWQLLKGRSVHYVPGWDcH-G 128
Cdd:PRK05729 8 TYdPKEVEAKWYQkWEEKGYfkpddNSKKPFSIVIPPPNVTGSLHMGHALNNTLQDILIRYKRMQGYNTLWLPGTD-HaG 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 129 LPIESKAIKA-NAERKSSLE------IRKIA--KDFANSAVQEQLmmfQRMAVMGDWpSR-YITMSDKFEIAELKVFLSL 198
Cdd:PRK05729 87 IATQMVVERQlAAEGKSRHDlgrekfLEKVWewKEESGGTITNQL---RRLGASCDW-SReRFTMDEGLSKAVREVFVRL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 199 LQKDLIFRQNKPVYWSSSSRSALAESEIEYDDnhVSTSIY-FTFPVNsfsiDGCEYnnvkALVWTTTPWTIPSNLALSYH 277
Cdd:PRK05729 163 YEKGLIYRGKRLVNWDPKLQTALSDLEVEYKE--VKGKLWhIRYPLA----DGSDY----LVVATTRPETMLGDTAVAVN 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 278 PEinyglYQHnnsiylmsdnLVpnldfmqGaKRLascpsdiissftyENPLLPKQsFPFLQSNYVTNDIGTGIVHVAPGH 357
Cdd:PRK05729 233 PEde--rYKH----------LI-------G-KTV-------------ILPLVGRE-IPIIADEYVDPEFGTGAVKITPAH 278
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 358 GMEDYLLGLENNLRPFSPLDDYGRYTKEAldGSLEGLEVLgDGGKKVISIMKNQNMIVKVSPYKHRYPYDWRTH---KPL 434
Cdd:PRK05729 279 DPNDFEVGKRHNLPMINIMDEDGTINENP--GEYQGLDRF-EARKAIVADLEELGLLVKIEPHTHSVGHSDRSGvviEPY 355
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 435 IlraTPQWFISLENERKTAIKALDS--VKMIPPNSRARLLGFLNG-RPeWCISRQRAWGLPIPVLYEKGTKIplltvksv 511
Cdd:PRK05729 356 L---SDQWFVKMKPLAKPALEAVENgeIKFVPERWEKTYFHWMENiQD-WCISRQLWWGHRIPAWYDEDGEV-------- 423
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 512 sYIIEkmevegvdswfNDTENNGHAQWVH-PDyrnkeyirgteTLDVWFDSGTsWttiaprknkPLIDLclegsdqhrGW 590
Cdd:PRK05729 424 -YVGR-----------EEPEAREKALLTQdED-----------VLDTWFSSAL-W---------PFSTL---------GW 461
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 591 -------------------------------FQSLLLTytayqskPEAPFSTLFTHGFIFDERGQKQSKSLGNVTDPEDV 639
Cdd:PRK05729 462 pektedlkrfyptsvlvtgfdiiffwvarmiMMGLHFT-------GQVPFKDVYIHGLVRDEQGRKMSKSKGNVIDPLDL 534
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 640 INgkllkgkklPYGVDLLRLWVASCDST-NDTNLGPNILTQVgeslkkWRLT------SRFCLGNLHDWNTSSSVDVGEL 712
Cdd:PRK05729 535 ID---------KYGADALRFTLAALASPgRDIRFDEERVEGY------RNFAnklwnaSRFVLMNLEGADVGELPDPEEL 599
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 713 RGIDKLALVQLDKFQTEIRELYESYSINKVVHHL-NYFMNSFlSSTYFDAVKDRLYADlpnsvSRRSVQTVLYHSLLTLI 791
Cdd:PRK05729 600 SLADRWILSRLNRTVAEVTEALDKYRFDEAARALyEFIWNEF-CDWYLELAKPVLQEA-----AKRATRATLAYVLEQIL 673
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 792 WAISPITPLLAQEIWQSLPDsylnssyqtpfHAGETHLISSLRSKVDLLDRKFLIKEYLVLQQlkysinlLITA---ARE 868
Cdd:PRK05729 674 RLLHPFMPFITEELWQKLAP-----------LGIEESIMLAPWPEADEAIDEAAEAEFEWLKE-------LITAirnIRA 735
|
890 900 910 920 930
....*....|....*....|....*....|....*....|....*....|....*..
gi 5701963 869 NLTIKNSLEAYVVIKSKSQSLLSFLKNYSSDLPFLFNTSKVFINEIPENLKLASVTQ 925
Cdd:PRK05729 736 EMNIPPSKKLPLLLKGADAEDRARLEANEAYIKRLARLESLEILADDEEAPEGAASA 792
|
|
| PTZ00419 |
PTZ00419 |
valyl-tRNA synthetase-like protein; Provisional |
60-810 |
2.25e-51 |
|
valyl-tRNA synthetase-like protein; Provisional
Pssm-ID: 240411 [Multi-domain] Cd Length: 995 Bit Score: 195.99 E-value: 2.25e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 60 KSITSDLYEW-----------QKENLNKEDSFVLLDGPPFANGRLHIGHALNKILKDIINRWQLLKGRSVHYVPGWDCHG 128
Cdd:PTZ00419 31 KEVESGWYEWweksgffkpaeDAKSLNSGKKFVIVLPPPNVTGYLHIGHALTGAIQDSLIRYHRMKGDETLWVPGTDHAG 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 129 LP----IESKAIKANAERKSSLE----IRKIA--KDFANSAVQEQLmmfQRMAVMGDWPSRYITMSDKFEIAELKVFLSL 198
Cdd:PTZ00419 111 IAtqvvVEKKLMKEENKTRHDLGreefLKKVWewKDKHGNNICNQL---RRLGSSLDWSREVFTMDEQRSKAVKEAFVRL 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 199 LQKDLIFRQNKPVYWSSSSRSALAESEIEYDDNHVSTSI---------------YFTFPVNsfsidgcEYNNVKALVWTT 263
Cdd:PTZ00419 188 YEDGLIYRDTRLVNWCCYLKTAISDIEVEFEEIEKPTKItipgydkkvevgvlwHFAYPLE-------DSGQEEIVVATT 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 264 TPWTIPSNLALSYHPEINYglYQHnnsiylmsdnlvpnldfMQGaKRLAscpsdiissftyeNPLLPKQSFPF-LQSNYV 342
Cdd:PTZ00419 261 RIETMLGDVAVAVHPKDER--YKK-----------------LHG-KELI-------------HPFIPDRKIPIiADDELV 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 343 TNDIGTGIVHVAPGHGMEDYLLGLENNLRPFSPLDDYGRYTKEAldGSLEGLEVLgDGGKKVISIMKNQNMIVKVSPYKH 422
Cdd:PTZ00419 308 DMEFGTGAVKITPAHDPNDYEIAKRHNLPFINIFTLDGKINENG--GEFAGMHRF-DCRRKIEEELKEMGLLRDKVPNPM 384
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 423 RYPYDWRTHKPLILRATPQWFISLENERKTAIKALDS--VKMIPPNSRARLLGFLNGRPEWCISRQRAWGLPIPVLYEKG 500
Cdd:PTZ00419 385 RLPRCSRSGDIVEPMLIPQWYVNCKDMAKRAVEAVRNgeLKIIPSSHENVWYHWLENIQDWCISRQLWWGHRIPAYRVIS 464
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 501 TKIPLLTVKSVSYIIEKMEVEGVDSWFNDTENNGHaqwvhpDYrnkEYIRGTETLDVWFDSG------TSWttiaPRKNK 574
Cdd:PTZ00419 465 KGPETDPSDEEPWVVARSEEEALEKAKKKFGLSEE------DF---ELEQDEDVLDTWFSSGlfpfstLGW----PDQTD 531
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 575 PLIDL----CLE-GSDQHRGW-----FQSLLLTytayqskPEAPFSTLFTHGFIFDERGQKQSKSLGNVTDPEDVING-- 642
Cdd:PTZ00419 532 DLQRFfptsLLEtGSDILFFWvarmvMMSLHLT-------DKLPFKTVFLHAMVRDSQGEKMSKSKGNVIDPLEVIEGis 604
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 643 ------KLLKG---------------KKLPYGV-----DLLRLWVASCdstndTNLGPNILTQVGESL-------KKWRL 689
Cdd:PTZ00419 605 lqdlnqKLYEGnlpekeikraielqkKEFPNGIpecgtDALRFGLLAY-----TQQGRNINLDINRVVgyrhfcnKLWNA 679
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 690 TsRFCLGNLHDWN------TSSSVDVGELRGIDKLALVQLDKFQTEIRELYESYSINKVVHHLNYFMNSFLSSTYFDAVK 763
Cdd:PTZ00419 680 V-KFALMKLLKDFnlpnstLFKPNNVESLPWEDKWILHRLNVAIKEVTEGFKEYDFSEATQATYNFWLYELCDVYLELIK 758
|
810 820 830 840 850
....*....|....*....|....*....|....*....|....*....|
gi 5701963 764 DRLyADLPNSVSRRSVQTVLYHSL---LTLiwaISPITPLLAQEIWQSLP 810
Cdd:PTZ00419 759 PRL-SKQSDGERKQHAQDVLHTVLdigLRL---LHPMMPFITEELYQRLP 804
|
|
| ValS |
COG0525 |
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase ... |
57-917 |
9.26e-46 |
|
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440291 [Multi-domain] Cd Length: 877 Bit Score: 177.94 E-value: 9.26e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 57 KY-FKSITSDLYE-WQKENLNKEDsfVLLDGPPFA------N--GRLHIGHALNKILKDIINRWQLLKGRSVHYVPGWDc 126
Cdd:COG0525 6 TYdPKEVEAKWYQyWEENGYFKAD--PDSDKEPFTivipppNvtGSLHMGHALNNTLQDILIRYKRMQGYNTLWQPGTD- 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 127 H-GLPIESKAIKA-NAERKSSLE------IRKIA--KDFANSAVQEQLmmfQRMAVMGDWpSR-YITMSDKFEIAELKVF 195
Cdd:COG0525 83 HaGIATQAVVERQlAEEGKSRHDlgrekfLERVWewKEESGGTITNQL---RRLGASCDW-SReRFTMDEGLSKAVREVF 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 196 LSLLQKDLIFRQNKPVYWSSSSRSALAESEIEYDDnhVSTSIY-FTFPVnsfsIDGCEYnnvkALVWTTTPWTIPSNLAL 274
Cdd:COG0525 159 VRLYEKGLIYRGKRLVNWDPKLKTALSDLEVEHEE--VKGHLWhIRYPL----ADGSGY----IVVATTRPETMLGDTAV 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 275 SYHPEinyglYQHnnsiylmsdnLVpnldfmqGaKRLascpsdiissftyENPLLPKQsFPFLQSNYVTNDIGTGIVHVA 354
Cdd:COG0525 229 AVHPEde--rYKH----------LI-------G-KTV-------------ILPLVGRE-IPIIADEYVDPEFGTGAVKIT 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 355 PGHGMEDYLLGLENNLRPFSPLDDYGRYTKEAldGSLEGLEVLgDGGKKVISIMKNQNMIVKVSPYKHRYPYDWRTH--- 431
Cdd:COG0525 275 PAHDPNDFEVGKRHNLPMINILDEDGTINENA--GKYRGLDRF-EARKAIVADLEELGLLVKVEPHKHSVGHSDRSGtvi 351
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 432 KPLIlraTPQWFISLENERKTAIKALDS--VKMIPPNSRARLLGFLNG-RPeWCISRQRAWGLPIPVLYEKGTKIplltv 508
Cdd:COG0525 352 EPYL---SDQWFVKMKPLAKPAIEAVEDgeIKFVPERWEKTYFHWMENiRD-WCISRQLWWGHRIPAWYCPDGEV----- 422
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 509 ksvsyIIEKMEVEgvdswfndtennghaqwVHPDYRNKEYIRGTETLDVWFDSGtSWTtIA----PRKNKpliDL----- 579
Cdd:COG0525 423 -----YVARTEPE-----------------ACAKAGSVNLTQDEDVLDTWFSSA-LWP-FStlgwPEKTE---DLkyfyp 475
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 580 --CLE-GSDqhrgW-----FQSLLLTytayqskPEAPFSTLFTHGFIFDERGQKQSKSLGNVTDPEDVINgkllkgkklP 651
Cdd:COG0525 476 tsVLVtGFDiiffWvarmiMMGLHFT-------GEVPFKDVYIHGLVRDEQGRKMSKSKGNVIDPLDLID---------K 539
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 652 YGVDLLRLWVASCDST-NDTNLGP-------NILTqvgeslKKWRlTSRFCLGNLHDWNTSSSVDVGELRGIDKLALVQL 723
Cdd:COG0525 540 YGADALRFTLAALASPgRDIKFDEervegyrNFAN------KLWN-ASRFVLMNLEGFDPGLDPDPEELSLADRWILSRL 612
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 724 DKFQTEIRELYESYSINKVVHHL-NYFMNSFlSSTYFDAVKDRLYADlpNSVSRRSVQTVLYHSLLTLIWAISPITPLLA 802
Cdd:COG0525 613 NKTIAEVTEALEKYRFDEAAQALyDFVWNEF-CDWYLELAKPRLYGG--DEAAKRETRATLVYVLEQILRLLHPFMPFIT 689
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 803 QEIWQSLPdsylnssyqtPFHAGETHLISSL-RSKVDLLDRKfLIKEYLVLQQlkysinlLITAAReNL----TIKNSLE 877
Cdd:COG0525 690 EEIWQKLP----------PRKEGESIMLAPWpEADEELIDEE-AEAEFEWLKE-------VISAIR-NIraemNIPPSKK 750
|
890 900 910 920
....*....|....*....|....*....|....*....|..
gi 5701963 878 AYVVIKSKSQSLLSFLKNYSSDLPFLFNTSKVFI--NEIPEN 917
Cdd:COG0525 751 LPLLLKGADEADRARLEENAAYIKRLARLEEITIlvDEKPEG 792
|
|
| ValRS_core |
cd00817 |
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) ... |
78-672 |
2.90e-43 |
|
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) catalytic core domain. This enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. ValRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 185677 [Multi-domain] Cd Length: 382 Bit Score: 162.03 E-value: 2.90e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 78 DSFVLLDGPPFANGRLHIGHALNKILKDIINRWQLLKGRSVHYVPGWDCHGLPIES---KAIKANAERKSSL---EIRKI 151
Cdd:cd00817 1 PVFVIDTPPPNVTGSLHMGHALNNTIQDIIARYKRMKGYNVLWPPGTDHAGIATQVvveKKLGIEGKTRHDLgreEFLEK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 152 AKDFANSAVQEQLMMFQRMAVMGDWPSRYITMSDKFEIAELKVFLSLLQKDLIFRQNKPVYWSSSSRSALAESEIeyddn 231
Cdd:cd00817 81 CWEWKEESGGKIREQLKRLGASVDWSREYFTMDPGLSRAVQEAFVRLYEKGLIYRDNRLVNWCPKLRTAISDIEV----- 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 232 hvstsiyftfpvnsfsidgCEynnvkalvwtttpwtipsnlalsyhpeinyglyqhnnsiylmsdnlvpnldfmqgakrl 311
Cdd:cd00817 156 -------------------CS----------------------------------------------------------- 157
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 312 aSCpSDIISsftyenPLLPKQSFpflqsnyvtndigtgivhvapghgmedyllglennlrpfsplddygrytkealdgsl 391
Cdd:cd00817 158 -RS-GDVIE------PLLKPQWF--------------------------------------------------------- 172
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 392 eglevlgdggkkvisimknqnmiVKVSPYKhrypydwrthkplilratpqwfislenerKTAIKALDS--VKMIPPNSRA 469
Cdd:cd00817 173 -----------------------VKVKDLA-----------------------------KKALEAVKEgdIKFVPERMEK 200
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 470 RLLGFLNGRPEWCISRQRAWGLPIPVLYekgtkiplltVKSVSY-IIEKMEVEGVDSwfndtenngHAQWVHPDYRNKEY 548
Cdd:cd00817 201 RYENWLENIRDWCISRQLWWGHRIPAWY----------CKDGGHwVVAREEDEAIDK---------AAPEACVPCGGEEL 261
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 549 IRGTETLDVWFDSG------TSW--TTIAPRKNKPLiDLCLEGSDQHRGW-FQSLLLTYTAYQskpEAPFSTLFTHGFIF 619
Cdd:cd00817 262 KQDEDVLDTWFSSSlwpfstLGWpeETKDLKKFYPT-SLLVTGHDIIFFWvARMIMRGLKLTG---KLPFKEVYLHGLVR 337
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|....
gi 5701963 620 DERGQKQSKSLGNVTDPEDVINGkllkgkklpYGVDLLRLWVASCDST-NDTNL 672
Cdd:cd00817 338 DEDGRKMSKSLGNVIDPLDVIDG---------YGADALRFTLASAATQgRDINL 382
|
|
| PLN02381 |
PLN02381 |
valyl-tRNA synthetase |
69-824 |
6.60e-37 |
|
valyl-tRNA synthetase
Pssm-ID: 215214 [Multi-domain] Cd Length: 1066 Bit Score: 150.82 E-value: 6.60e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 69 WQKENLNKEDS------FVLLDGPPFANGRLHIGHALNKILKDIINRWQLLKGRSVHYVPGWDCHGLP----IESKAIKa 138
Cdd:PLN02381 113 WEKSGYFGADAksskppFVIVLPPPNVTGALHIGHALTAAIEDTIIRWKRMSGYNALWVPGVDHAGIAtqvvVEKKLMR- 191
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 139 naERKSSL----------EIRKiAKDFANSAVQEQLmmfQRMAVMGDWPSRYITMSDKFEIAELKVFLSLLQKDLIFRQN 208
Cdd:PLN02381 192 --ERHLTRhdigreefvsEVWK-WKDEYGGTILNQL---RRLGASLDWSRECFTMDEQRSKAVTEAFVRLYKEGLIYRDI 265
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 209 KPVYWSSSSRSALAESEIEYDDNHVSTS---------------IYFTFPVnsfsidgcEYNNVKALVWTTTPWTIPSNLA 273
Cdd:PLN02381 266 RLVNWDCTLRTAISDVEVDYIDIKERTLlkvpgydkpvefgvlTSFAYPL--------EGGLGEIVVATTRIETMLGDTA 337
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 274 LSYHPEinYGLYQHNNSIYLMSDnlvpnldfMQGAKRLASCPSDIissftyenpllpkqsfpflqsnyVTNDIGTGIVHV 353
Cdd:PLN02381 338 IAIHPD--DERYKHLHGKFAVHP--------FNGRKLPIICDAIL-----------------------VDPNFGTGAVKI 384
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 354 APGHGMEDYLLGLENNLRPFSPLDDYGRYTkealdgSLEGLEVLG----DGGKKVISIMKNQNMIVKVSPYKHRYPYDWR 429
Cdd:PLN02381 385 TPAHDPNDFEVGKRHNLEFINIFTDDGKIN------SNGGSEFAGmprfAAREAVIEALQKKGLYRGAKNNEMRLGLCSR 458
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 430 TH---KPLIlraTPQWFISLENERKTAIKALDS-----VKMIPPNSRARLLGFLNGRPEWCISRQRAWGLPIPVLYekgt 501
Cdd:PLN02381 459 TNdvvEPMI---KPQWFVNCSSMAKQALDAAIDgenkkLEFIPKQYLAEWKRWLENIRDWCISRQLWWGHRIPAWY---- 531
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 502 kiplltvksVSYIIEKMEVEGV--DSWF---NDTENNGHAQWVHPDyRNKEYIRGTETLDVWFDSGTSWTTIA--PRKNK 574
Cdd:PLN02381 532 ---------VTLEDDQLKELGSynDHWVvarNESDALLEASQKFPG-KKFELSQDPDVLDTWFSSGLFPLSVLgwPDDTD 601
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 575 PLIDL----CLE-GSDQHRGWFQSLLLtyTAYQSKPEAPFSTLFTHGFIFDERGQKQSKSLGNVTDPEDVINGKLLKG-- 647
Cdd:PLN02381 602 DLKAFyptsVLEtGHDILFFWVARMVM--MGMQLGGDVPFRKVYLHPMIRDAHGRKMSKSLGNVIDPLEVINGISLEGlh 679
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 648 ---------------------KKLPYGV-----DLLRLWVASCDSTND-TNLgpNILTQVGESL---KKWRLTsRFCLGN 697
Cdd:PLN02381 680 krleegnldpkelvvakegqkKDFPNGIaecgtDALRFALVSYTAQSDkINL--DILRVVGYRQwcnKLWNAV-RFAMSK 756
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 698 L-HDWNTSSSVDVGELRGIDKLALVQLDKfqteirelyesySINKVVHHLNYFMNSFLSST------------YFDAVKD 764
Cdd:PLN02381 757 LgDDYTPPATLSVETMPFSCKWILSVLNK------------AISKTVSSLDAYEFSDAASTvyswwqyqfcdvFIEAIKP 824
|
810 820 830 840 850 860
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 5701963 765 RLYADLPNSVSRRS-VQTVLYHSLLTLIWAISPITPLLAQEIWQSLP--------DSYLNSSYQTPFHA 824
Cdd:PLN02381 825 YFAGDNPEFASERAaAQDTLWICLDTGLRLLHPFMPFVTEELWQRLPqpkdhtrkDSIMISEYPSAVEA 893
|
|
| Ile_Leu_Val_MetRS_core |
cd00668 |
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic ... |
428-666 |
4.72e-31 |
|
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases. These class I enzymes are all monomers. However, in some species, MetRS functions as a homodimer, as a result of an additional C-terminal domain. These enzymes aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. Enzymes in this subfamily share an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids. MetRS has a significantly shorter insertion, which lacks the editing function.
Pssm-ID: 185674 [Multi-domain] Cd Length: 312 Bit Score: 124.45 E-value: 4.72e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 428 WRTHKPLilRATPQWFISLENERKTAIKALDSVKMIPPNSRARLLGFLNGRPEWCISRQRAWGLPIPvlyekgtkipllt 507
Cdd:cd00668 130 YRGTHPV--RITEQWFFDMPKFKEKLLKALRRGKIVPEHVKNRMEAWLESLLDWAISRQRYWGTPLP------------- 194
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 508 vksvsyiiekmevegvdswfndtennghaqwvhpdyrnkeyirgTETLDVWFDSGTSW--TTIAPRKNKPL-----IDLC 580
Cdd:cd00668 195 --------------------------------------------EDVFDVWFDSGIGPlgSLGYPEEKEWFkdsypADWH 230
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 581 LEGSDQHRGWFQSLLLTYTAyqSKPEAPFSTLFTHGFIFDERGQKQSKSLGNVTDPEDVINgkllkgkklPYGVDLLRLW 660
Cdd:cd00668 231 LIGKDILRGWANFWITMLVA--LFGEIPPKNLLVHGFVLDEGGQKMSKSKGNVIDPSDVVE---------KYGADALRYY 299
|
....*.
gi 5701963 661 VASCDS 666
Cdd:cd00668 300 LTSLAP 305
|
|
| Ile_Leu_Val_MetRS_core |
cd00668 |
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic ... |
80-212 |
6.40e-28 |
|
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases. These class I enzymes are all monomers. However, in some species, MetRS functions as a homodimer, as a result of an additional C-terminal domain. These enzymes aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. Enzymes in this subfamily share an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids. MetRS has a significantly shorter insertion, which lacks the editing function.
Pssm-ID: 185674 [Multi-domain] Cd Length: 312 Bit Score: 115.21 E-value: 6.40e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 80 FVLLDGPPFANGRLHIGHALNKILKDIINRWQLLKGRSVHYVPGWDCHGLPIESKAIKANAERKSS---LEIRKIAKDFA 156
Cdd:cd00668 2 FYVTTPPPYANGSLHLGHALTHIIADFIARYKRMRGYEVPFLPGWDTHGLPIELKAERKGGRKKKTiwiEEFREDPKEFV 81
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 5701963 157 NSAVQEQLMMFQRMAVMGDWPSRYITMSDKFEIAELKVFLSLLQKDLIFRQNKPVY 212
Cdd:cd00668 82 EEMSGEHKEDFRRLGISYDWSDEYITTEPEYSKAVELIFSRLYEKGLIYRGTHPVR 137
|
|
| Anticodon_1 |
pfam08264 |
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA ... |
716-882 |
1.22e-24 |
|
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA synthetases. The domain binds to the anticodon of the tRNA ligase.
Pssm-ID: 400523 [Multi-domain] Cd Length: 141 Bit Score: 100.56 E-value: 1.22e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 716 DKLALVQLDKFQTEIRELYESYSINKVVHHLNYFMNSFLSSTYFDAVKDRLYADLPNSvsrrSVQTVLYHSLLTLIWAIS 795
Cdd:pfam08264 1 DRWILSRLNKLIKEVTEAYENYRFNTAAQALYEFFWNDLSDWYLELIKDRLYGEEPDS----RAQTTLYEVLETLLRLLA 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 796 PITPLLAQEIWQSlpDSYLNSSYqtPfhagethlisslrskvdlLDRKFLIKEYLVLQQLKYSINLLITAARENLTIKNS 875
Cdd:pfam08264 77 PFMPFITEELWQK--ESIHLAPW--P------------------EDAELEEAELEEAFELRQEIVQAIRKLRSELKIKKS 134
|
....*..
gi 5701963 876 LEAYVVI 882
Cdd:pfam08264 135 LPLEVVI 141
|
|
| leuS |
PRK12300 |
leucyl-tRNA synthetase; Reviewed |
93-809 |
1.59e-15 |
|
leucyl-tRNA synthetase; Reviewed
Pssm-ID: 237049 [Multi-domain] Cd Length: 897 Bit Score: 81.45 E-value: 1.59e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 93 LHIGHALNKILKDIINRWQLLKGRSVHYVPGWDCHGLPIE--SKAIKANAER-----KSSLEI-----------RKIAKD 154
Cdd:PRK12300 1 LHVGHGRTYTIGDVIARYKRMRGYNVLFPMAFHVTGTPILgiAERIARGDPEtielyKSLYGIpeeelekfkdpEYIVEY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 155 FANSAvqeqLMMFQRMAVMGDWPSRYITMSDKFEiaelKV----FLSLLQKDLIFRQNKPVYWSSSSRSAL--------A 222
Cdd:PRK12300 81 FSEEA----KEDMKRIGYSIDWRREFTTTDPEYS----KFiewqFRKLKEKGLIVKGSHPVRYCPNDNNPVgdhdlldgE 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 223 ESEI-EYddnhvsTSIYFTfpvnsfsidgcEYNNVKALVWTTTPWTIPSNLALSYHPEINYGLYQHNNSIYLMSDNLVPN 301
Cdd:PRK12300 153 EPEIvEY------TLIKFE-----------ESEDLILPAATLRPETIFGVTNLWVNPDATYVKAEVDGEKWIVSKEAAEK 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 302 LDFmQGAK----RLAScPSDIISSfTYENPLLPKQsFPFLQSNYVTNDIGTGIVHVAPGHGMEDY-----LLGLENNLRP 372
Cdd:PRK12300 216 LSF-QDRDveiiEEIK-GSELIGK-KVKNPVTGKE-VPILPADFVDPDNGTGVVMSVPAHAPYDYvalrdLKKNKELLDV 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 373 FSP-----LDDYGRY----------TKEALDGSLEGL---------------EVLGD-GGKKVISIMKNqnmIVK--VSP 419
Cdd:PRK12300 292 IEPiplieVEGYGEFpakevveklgIKSQEDPELEEAtkevyraefhkgvlkENTGEyAGKPVREAREK---ITKdlIEK 368
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 420 YKHRYPYDWrTHKPLILRA-TP--------QWFISLENER--KTAIKALDSVKMIPPNSRA---RLLGFLNgrpEWCISR 485
Cdd:PRK12300 369 GIADIMYEF-SNRPVYCRCgTEcvvkvvkdQWFIDYSDPEwkELAHKALDNMEIIPEEYRKefeNTIDWLK---DRACAR 444
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 486 QRAWGLPIPvlYEKGTKIPLL---TVKSVSYII-EKMEVEGVDswfndtennghaqwvhPDYRNKE---YI---RGTETl 555
Cdd:PRK12300 445 RRGLGTRLP--WDEEWIIESLsdsTIYMAYYTIaHKIREYGIK----------------PEQLTPEffdYVflgKGDPE- 505
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 556 DVWFDSGTSWTTIAPRKNK-----PLiDLCLEGSD---QHrgwfqsllLTYtayqskpeapFstLFTHGFIFDER----- 622
Cdd:PRK12300 506 EVSKKTGIPKEILEEMREEflywyPV-DWRHSGKDlipNH--------LTF----------F--IFNHVAIFPEEkwprg 564
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 623 ----------GQKQSKSLGNVTDPEDVINgkllkgkklPYGVDLLRLWVASCDS-TNDTNLGPNILTQVGESLKKWR-LT 690
Cdd:PRK12300 565 ivvngfvlleGKKMSKSKGNVIPLRKAIE---------EYGADVVRLYLTSSAElLQDADWREKEVESVRRQLERFYeLA 635
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 691 SRFclgnlhdwntSSSVDVGELRGIDKLALVQLDKFQTEIRELYESYSINKVVHHLNY-FMNSFlsSTYFDAVKDRlyad 769
Cdd:PRK12300 636 KEL----------IEIGGEEELRFIDKWLLSRLNRIIKETTEAMESFQTRDAVQEAFYeLLNDL--RWYLRRVGEA---- 699
|
810 820 830 840
....*....|....*....|....*....|....*....|
gi 5701963 770 lpnsvsrrsVQTVLYHSLLTLIWAISPITPLLAQEIWQSL 809
Cdd:PRK12300 700 ---------NNKVLREVLEIWIRLLAPFTPHLAEELWHKL 730
|
|
| LeuS |
COG0495 |
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA ... |
481-809 |
2.59e-15 |
|
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440261 [Multi-domain] Cd Length: 826 Bit Score: 80.87 E-value: 2.59e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 481 WCISRQRAWGLPIPVLY-EKGTKIPLLtvksvsyiiEKM------EVegVDswFNDTENN---GHAQWVH--PDYRNKEY 548
Cdd:COG0495 422 WLISRQRYWGEPIPIIHcEDCGVVPVP---------EDQlpvelpED--VD--FDPTGGSplaRAPEWVNvtCPKCGGPA 488
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 549 IRGTETLDVWFDSgtSW-----TtiAPRKNKPLIDLCLEGS----DQ----------HrgwfqslLLtY----------T 599
Cdd:COG0495 489 RRETDTMDTFVDS--SWyylryT--DPHNDEAPFDPEAANYwlpvDQyiggiehailH-------LL-YarfftkvlrdL 556
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 600 AYQSKPEaPFSTLFTHGFIFD--------ERGQKQSKSLGNVTDPEDVINgkllkgkklPYGVDLLRLWVAScdstndtn 671
Cdd:COG0495 557 GLVSFDE-PFKRLLTQGMVLEvgkdgvviGGIEKMSKSKGNVVDPDEIIE---------KYGADTLRLFEMF-------- 618
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 672 LGPniLTQVGE-S----------LKK-WRLTsrfclgnlHDWNTSSSVDVGELRGIDKLALVQLDKFQTEIRELYESYSI 739
Cdd:COG0495 619 AGP--PERDLEwSdsgvegayrfLNRvWRLV--------VDEAEALKLDVADLSEADKELRRALHKTIKKVTEDIERLRF 688
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 740 NKVVHHLNYFMNSflsstyfdavkdrLYADLPNSVSRRSvqtVLYHSLLTLIWAISPITPLLAQEIWQSL 809
Cdd:COG0495 689 NTAIAALMELVNA-------------LYKAKDSGEADRA---VLREALETLVLLLAPFAPHIAEELWERL 742
|
|
| MetG |
COG0143 |
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA ... |
87-207 |
6.07e-14 |
|
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439913 [Multi-domain] Cd Length: 544 Bit Score: 75.54 E-value: 6.07e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 87 PFANGRLHIGHALNKILKDIINRWQLLKGRSVHYVPGWDCHGLPIESKAIKANaerkssleirKIAKDFANSAVQEQLMM 166
Cdd:COG0143 10 PYANGPPHIGHLYTYIPADILARYQRLRGHDVLFVTGTDEHGTKIELAAEKEG----------ITPQELVDRIHAEFKEL 79
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 5701963 167 FQRMAVMGDwpsRYITMSDK--FEIAElKVFLSLLQKDLIFRQ 207
Cdd:COG0143 80 FEKLGISFD---NFIRTTSPehKELVQ-EIFQRLYDNGDIYKG 118
|
|
| LeuRS_core |
cd00812 |
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ... |
87-213 |
1.80e-13 |
|
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173906 [Multi-domain] Cd Length: 314 Bit Score: 72.28 E-value: 1.80e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 87 PFANGRLHIGHALNKILKDIINRWQLLKGRSVHYVPGWDCHGLPIESKAIKANAERKssleirKIAKDFANSAvQEQlmm 166
Cdd:cd00812 9 PYPSGALHVGHVRTYTIGDIIARYKRMQGYNVLFPMGFDAFGLPAENAAIKIGRDPE------DWTEYNIKKM-KEQ--- 78
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 5701963 167 FQRMAVMGDWpSRYITMSD-KFEIAELKVFLSLLQKDLIFRQNKPVYW 213
Cdd:cd00812 79 LKRMGFSYDW-RREFTTCDpEYYKFTQWLFLKLYEKGLAYKKEAPVNW 125
|
|
| MetRS_core |
cd00814 |
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ... |
87-139 |
3.02e-13 |
|
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.
Pssm-ID: 173907 [Multi-domain] Cd Length: 319 Bit Score: 71.79 E-value: 3.02e-13
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 5701963 87 PFANGRLHIGHALNKILKDIINRWQLLKGRSVHYVPGWDCHGLPIESKAIKAN 139
Cdd:cd00814 9 PYVNGVPHLGHLYGTVLADVFARYQRLRGYDVLFVTGTDEHGTKIEQKAEEEG 61
|
|
| Anticodon_Ia_Val |
cd07962 |
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA ... |
691-809 |
6.66e-13 |
|
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA synthetases (ValRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. ValRS catalyzes the transfer of valine to the 3'-end of its tRNA.
Pssm-ID: 153416 [Multi-domain] Cd Length: 135 Bit Score: 66.81 E-value: 6.66e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 691 SRFCLGNLHDwNTSSSVDVGELRGIDKLALVQLDKFQTEIRELYESYSINKVVHHL-NYFMNSFlSSTYFDAVKDRLYAD 769
Cdd:cd07962 20 ARFVLMNLED-DDEPEEDPESLSLADRWILSRLNKTVEEVTEALENYRFSEAATALyEFFWNDF-CDWYLELVKPRLYGE 97
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 5701963 770 lpNSVSRRSVQTVLYHSLLTLIWAISPITPLLAQEIWQSL 809
Cdd:cd07962 98 --DEEEKKAARATLYYVLETILRLLHPFMPFITEELWQRL 135
|
|
| metG |
TIGR00398 |
methionine--tRNA ligase; The methionyl-tRNA synthetase (metG) is a class I amino acyl-tRNA ... |
87-227 |
2.55e-12 |
|
methionine--tRNA ligase; The methionyl-tRNA synthetase (metG) is a class I amino acyl-tRNA ligase. This model appears to recognize the methionyl-tRNA synthetase of every species, including eukaryotic cytosolic and mitochondrial forms. The UPGMA difference tree calculated after search and alignment according to this model shows an unusual deep split between two families of MetG. One family contains forms from the Archaea, yeast cytosol, spirochetes, and E. coli, among others. The other family includes forms from yeast mitochondrion, Synechocystis sp., Bacillus subtilis, the Mycoplasmas, Aquifex aeolicus, and Helicobacter pylori. The E. coli enzyme is homodimeric, although monomeric forms can be prepared that are fully active. Activity of this enzyme in bacteria includes aminoacylation of fMet-tRNA with Met; subsequent formylation of the Met to fMet is catalyzed by a separate enzyme. Note that the protein from Aquifex aeolicus is split into an alpha (large) and beta (small) subunit; this model does not include the C-terminal region corresponding to the beta chain. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273058 [Multi-domain] Cd Length: 530 Bit Score: 70.48 E-value: 2.55e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 87 PFANGRLHIGHALNKILKDIINRWQLLKGRSVHYVPGWDCHGLPIESKAIKANaerkssleirKIAKDFANSAVQEQLMM 166
Cdd:TIGR00398 8 PYANGKPHLGHAYTTILADVYARYKRLRGYEVLFVCGTDEHGTKIELKAEQEG----------LTPKELVDKYHEEFKDD 77
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 5701963 167 FQRMAVMGDwpsRYITMSDKF--EIAElKVFLSLLQKDLIFRQNKPVYWSSSSRSALAESEIE 227
Cdd:TIGR00398 78 WKWLNISFD---RFIRTTDEEhkEIVQ-KIFQKLKENGYIYEKEIKQLYCPECEMFLPDRYVE 136
|
|
| PRK11893 |
PRK11893 |
methionyl-tRNA synthetase; Reviewed |
613-809 |
1.09e-11 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237012 [Multi-domain] Cd Length: 511 Bit Score: 68.37 E-value: 1.09e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 613 FTHGFIFDErGQKQSKSLGNVTDPEDVINgkllkgkklPYGVDLLRLWVASCDSTNDT-----------------NLGPN 675
Cdd:PRK11893 288 FAHGFLTLD-GEKMSKSLGNVIDPFDLVD---------EYGVDAVRYFLLREIPFGQDgdfsreafinrinadlaNDLGN 357
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 676 ILTQVGESLKKWrltsrfCLGNLHdwntsssvDVGELRGIDKLALVQLDKFQTEIRELYESYSINKVvhhLNYFMN-SFL 754
Cdd:PRK11893 358 LAQRTLSMIAKN------FDGKVP--------EPGALTEADEALLEAAAALLERVRAAMDNLAFDKA---LEAILAlVRA 420
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 5701963 755 SSTYFDAVKD-RLYADLPNSVSrrsvqTVLYHSLLTLI---WAISPITPLLAQEIWQSL 809
Cdd:PRK11893 421 ANKYIDEQAPwSLAKTDPERLA-----TVLYTLLEVLRgiaVLLQPVMPELAAKILDQL 474
|
|
| tRNA-synt_1g |
pfam09334 |
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases. |
87-227 |
1.36e-11 |
|
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.
Pssm-ID: 401322 [Multi-domain] Cd Length: 387 Bit Score: 67.32 E-value: 1.36e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 87 PFANGRLHIGHALNKILKDIINRWQLLKGRSVHYVPGWDCHGLPIESKAIKANAErkssleirkiAKDFANSAVQEQLMM 166
Cdd:pfam09334 8 PYANGPPHLGHLYSYIPADIFARYLRLRGYDVLFVCGTDEHGTPIELKAEKEGIT----------PEELVDRYHEIHRED 77
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 5701963 167 FQRMAVMGDWPSRyiTMSDKFEIAELKVFLSLLQKDLIFRQNKPVYWSSSSRSALAESEIE 227
Cdd:pfam09334 78 FKKFNISFDDYGR--TTSERHHELVQEFFLKLYENGYIYEKEIEQFYCPSDERFLPDRYVE 136
|
|
| PLN02563 |
PLN02563 |
aminoacyl-tRNA ligase |
80-832 |
6.67e-11 |
|
aminoacyl-tRNA ligase
Pssm-ID: 178177 [Multi-domain] Cd Length: 963 Bit Score: 66.39 E-value: 6.67e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 80 FVLLDGPPFANGR-LHIGHALNKILKDIINRWQLLKGRSVHYVPGWDCHGLPIESKAIKANAERKSSLEiRKIAKdfans 158
Cdd:PLN02563 112 FYVLDMFPYPSGAgLHVGHPEGYTATDILARYKRMQGYNVLHPMGWDAFGLPAEQYAIETGTHPKITTL-KNIAR----- 185
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 159 aVQEQLmmfQRMAVMGDWpSRYITMSDKfeiAELK----VFLSLLQKDLIFRQNKPVYWSSSSRSALAESEI-------- 226
Cdd:PLN02563 186 -FRSQL---KSLGFSYDW-DREISTTEP---EYYKwtqwIFLQLLKRGLAYQAEVPVNWCPALGTVLANEEVvdglserg 257
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 227 -----------------EYDDNHVSTSIYFTFPVN-----------------SFSIDGCE--YNNVKALVWTTTPWTIPS 270
Cdd:PLN02563 258 ghpvirkpmrqwmlkitAYADRLLEDLDDLDWPESikemqrnwigrsegaelDFSVLDGEgkERDEKITVYTTRPDTLFG 337
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 271 NLALSYHPEinyglyqHNNSIYLMSDNLVPNLDfmqGAKRLASCPSDI-----------ISSFTY-ENPlLPKQSFPFLQ 338
Cdd:PLN02563 338 ATYLVVAPE-------HPLLSSLTTAEQKEAVE---EYVDAASRKSDLertelqkektgVFTGSYaINP-ATGEAIPIWV 406
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 339 SNYVTNDIGTGIVHVAPGHGMEDYLLGLENNL-----------------RPF-----------SPLDDYGRYTKEALDGS 390
Cdd:PLN02563 407 ADYVLGSYGTGAIMAVPAHDTRDFEFAQKFDLpikwvvkpadgneddaeKAYtgegvivnsssSGLDINGLSSKEAAKKV 486
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 391 LEGLEVLGDGGKKVisimknqnmivkvsPYKHRypydwrthkplilratpqwfislenerktaikaldsvkmippnsrar 470
Cdd:PLN02563 487 IEWLEETGNGKKKV--------------NYKLR----------------------------------------------- 505
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 471 llgflngrpEWCISRQRAWGLPIPVLY--EKGTKIPL------LTVKSVSYIIEKMEVEG----VDSWFNDTENNGhaqw 538
Cdd:PLN02563 506 ---------DWLFARQRYWGEPIPVVFleDSGEPVPVpesdlpLTLPELDDFTPTGTGEPplakAVSWVNTVDPSS---- 572
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 539 vhpdyrNKEYIRGTETLDVWfdSGTSW---TTIAPRKNKPLIDLCLE----------GSDQH--------RGWFQslLLT 597
Cdd:PLN02563 573 ------GKPARRETNTMPQW--AGSCWyylRFMDPKNSNALVDKEKEkywmpvdlyvGGAEHavlhllyaRFWHK--VLY 642
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 598 YTAYQSKPEaPFSTLFTHGFIFDE------------------------------------------------------RG 623
Cdd:PLN02563 643 DIGVVSTKE-PFQCLVNQGMILGEveytafkdsdgeyvsadtadrlgelqqekipeekviksgdsfvlkddpsirliaRA 721
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 624 QKQSKSLGNVTDPEDVIngkllkgkkLPYGVDLLRLWvascdstnDTNLGPNiltqvgESLKKWRLT-----SRFcLGNL 698
Cdd:PLN02563 722 HKMSKSRGNVVNPDDVV---------SEYGADSLRLY--------EMFMGPL------RDSKTWSTSgvegvHRF-LGRT 777
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 699 HD-----WNTSSSVDVGELRGIDKLALVQ---LDKFQTEIRELYESYSINKVVHHLNYFMNSFLSstyfdavkdrlYADL 770
Cdd:PLN02563 778 WRlvvgaPLPDGSFRDGTVVTDEEPSLEQlrlLHKCIAKVTEEIESTRFNTAISAMMEFTNAAYK-----------WDKV 846
|
890 900 910 920 930 940
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 5701963 771 PNSVSRRSVqtvlyhsLLtliwaISPITPLLAQEIWQSLPDSylNS-SYQTPFHAGETHLISS 832
Cdd:PLN02563 847 PREAIEPFV-------LL-----LSPYAPHLAEELWFRLGHS--NSlAYEPWPEANPSYLVDD 895
|
|
| metG |
PRK00133 |
methionyl-tRNA synthetase; Reviewed |
87-138 |
8.64e-09 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 234655 [Multi-domain] Cd Length: 673 Bit Score: 59.39 E-value: 8.64e-09
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 5701963 87 PFANGRLHIGHALNKILKDIINRWQLLKGRSVHYVPGWDCHGLPIESKAIKA 138
Cdd:PRK00133 11 PYANGPIHLGHLVEYIQADIWVRYQRMRGHEVLFVCADDAHGTPIMLKAEKE 62
|
|
| LeuRS_core |
cd00812 |
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ... |
420-664 |
9.53e-09 |
|
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173906 [Multi-domain] Cd Length: 314 Bit Score: 58.03 E-value: 9.53e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 420 YKHRYPYDWRthkplilRATPQWFISLENE--RKTAIKALDSVKMIPPNSRARLLGFLNgrpewcISRQRAWGLPIPVly 497
Cdd:cd00812 117 YKKEAPVNWC-------KLLDQWFLKYSETewKEKLLKDLEKLDGWPEEVRAMQENWIG------CSRQRYWGTPIPW-- 181
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 498 ekgtkiplltvksvsyiiekmevegvdswfndtennghaqwvhpdyrnkeyirgTETLDVWFDSgtSWT----TIAPRKN 573
Cdd:cd00812 182 ------------------------------------------------------TDTMESLSDS--TWYyaryTDAHNLE 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 574 KPLIDLCLEGSDQHRGWFQ-----------SLLLTYTAYQSK--------PEAPFSTLFTHGFIFDErGQKQSKSLGNVT 634
Cdd:cd00812 206 QPYEGDLEFDREEFEYWYPvdiyiggkehaPNHLLYSRFNHKalfdeglvTDEPPKGLIVQGMVLLE-GEKMSKSKGNVV 284
|
250 260 270
....*....|....*....|....*....|
gi 5701963 635 DPEDVIngkllkgKKlpYGVDLLRLWVASC 664
Cdd:cd00812 285 TPDEAI-------KK--YGADAARLYILFA 305
|
|
| PRK11893 |
PRK11893 |
methionyl-tRNA synthetase; Reviewed |
86-175 |
1.65e-08 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237012 [Multi-domain] Cd Length: 511 Bit Score: 58.35 E-value: 1.65e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 86 PPFANGRLHIGHALNKILKDIINRWQLLKGRSVHYVPGWDCHGLPIESKAIKANAE-----RKSSLEIRKIAK------- 153
Cdd:PRK11893 9 IYYPNGKPHIGHAYTTLAADVLARFKRLRGYDVFFLTGTDEHGQKIQRKAEEAGISpqelaDRNSAAFKRLWEalnisyd 88
|
90 100
....*....|....*....|....*....
gi 5701963 154 DF-------ANSAVQEqlmMFQRMAVMGD 175
Cdd:PRK11893 89 DFirttdprHKEAVQE---IFQRLLANGD 114
|
|
| PRK12267 |
PRK12267 |
methionyl-tRNA synthetase; Reviewed |
90-139 |
4.24e-08 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237028 [Multi-domain] Cd Length: 648 Bit Score: 57.12 E-value: 4.24e-08
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 5701963 90 NGRLHIGHALNKILKDIINRWQLLKGRSVHYVPGWDCHGLPIESKAIKAN 139
Cdd:PRK12267 16 NGKPHIGHAYTTIAADALARYKRLQGYDVFFLTGTDEHGQKIQQAAEKAG 65
|
|
| Anticodon_Ia_Ile_ABEc |
cd07961 |
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA ... |
697-809 |
1.89e-06 |
|
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial, archaeal, and eukaryotic cytoplasmic members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
Pssm-ID: 153415 [Multi-domain] Cd Length: 183 Bit Score: 49.09 E-value: 1.89e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 697 NLHDWNTSS-SVDVGELRGIDKLALVQLDKFQTEIRELYESYSINKVVHHLNYFMNSfLSSTYFDAVKDRLYADLpNSVS 775
Cdd:cd07961 29 NLDGFDPGKdDDAVASLNVLDRWILSRLNSLIKEVTEEMEAYDLYTAVRALLEFIDE-LTNWYIRRNRKRFWGEE-GDDD 106
|
90 100 110
....*....|....*....|....*....|....
gi 5701963 776 RRSVQTVLYHSLLTLIWAISPITPLLAQEIWQSL 809
Cdd:cd07961 107 KLAAYATLYEVLLTLSRLMAPFTPFITEEIYQNL 140
|
|
| PRK12267 |
PRK12267 |
methionyl-tRNA synthetase; Reviewed |
612-658 |
1.78e-04 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237028 [Multi-domain] Cd Length: 648 Bit Score: 45.56 E-value: 1.78e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 5701963 612 LFTHGFIFDErGQKQSKSLGNVTDPEDVINgkllkgkklPYGVDLLR 658
Cdd:PRK12267 287 VFAHGWWLMK-DGKMSKSKGNVVDPEELVD---------RYGLDALR 323
|
|
| class_I_aaRS_core |
cd00802 |
catalytic core domain of class I amino acyl-tRNA synthetase; Class I amino acyl-tRNA ... |
86-156 |
4.43e-04 |
|
catalytic core domain of class I amino acyl-tRNA synthetase; Class I amino acyl-tRNA synthetase (aaRS) catalytic core domain. These enzymes are mostly monomers which aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding.
Pssm-ID: 173901 [Multi-domain] Cd Length: 143 Bit Score: 41.70 E-value: 4.43e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 5701963 86 PPFANGRLHIGHALNKILKDIINRWQLLKGRSVHYVPGWDCHGLPIESKAIKANAERKSSLE--IRKIAKDFA 156
Cdd:cd00802 5 GITPNGYLHIGHLRTIVTFDFLAQAYRKLGYKVRCIALIDDAGGLIGDPANKKGENAKAFVErwIERIKEDVE 77
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| Anticodon_Ia_like |
cd07375 |
Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; This ... |
674-798 |
2.92e-03 |
|
Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; This domain is found in a variety of class Ia aminoacyl tRNA synthetases, C-terminal to the catalytic core domain. It recognizes and specifically binds to the anticodon of the tRNA. Aminoacyl tRNA synthetases catalyze the transfer of cognate amino acids to the 3'-end of their tRNAs by specifically recognizing cognate from non-cognate amino acids. Members include valyl-, leucyl-, isoleucyl-, cysteinyl-, arginyl-, and methionyl-tRNA synthethases. This superfamily also includes a domain from MshC, an enzyme in the mycothiol biosynthetic pathway.
Pssm-ID: 153408 [Multi-domain] Cd Length: 117 Bit Score: 38.64 E-value: 2.92e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5701963 674 PNILTQVGESLKKWRLTSRFCLGNLHDwnTSSSVDVGELRGIDKLALVQLDKFQTEIRELYESYSINKVVHHLNYFMNSF 753
Cdd:cd07375 1 EERLKQARAFLNRLYRLLSFFRKALGG--TQPKWDNELLEEADRELLARLQEFIKRTTNALEALDPTTAVQELFKFTNEL 78
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 5701963 754 lsSTYFDAVKDRLYADLpnsvSRRSVQTVLYHSLLTLIWAISPIT 798
Cdd:cd07375 79 --NWYLDELKPALQTEE----LREAVLAVLRAALVVLTKLLAPFT 117
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| MetRS_core |
cd00814 |
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ... |
610-658 |
5.04e-03 |
|
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.
Pssm-ID: 173907 [Multi-domain] Cd Length: 319 Bit Score: 40.21 E-value: 5.04e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 5701963 610 STLFTHGFIFDErGQKQSKSLGNVTDPEDVINGkllkgkklpYGVDLLR 658
Cdd:cd00814 266 TRIVAHGYLTVE-GKKMSKSRGNVVDPDDLLER---------YGADALR 304
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|
| PLN02224 |
PLN02224 |
methionine-tRNA ligase |
70-135 |
6.04e-03 |
|
methionine-tRNA ligase
Pssm-ID: 177869 [Multi-domain] Cd Length: 616 Bit Score: 40.47 E-value: 6.04e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 5701963 70 QKENLNKEDSFVLLDGPPFANGRLHIGHALNKILKDIINRWQLLKGRSVHYVPGWDCHGLPIESKA 135
Cdd:PLN02224 61 QESTVDEADTFVLTTPLYYVNAPPHMGSAYTTIAADSIARFQRLLGKKVIFITGTDEHGEKIATSA 126
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