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Conserved domains on  [gi|6689089|emb|CAB65383|]
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MASP-2 protein, partial [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Tryp_SPc cd00190
Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens ...
 300-537 3.92e-80

Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad residues.


:

Pssm-ID: 238113 [Multi-domain]  Cd Length: 232  Bit Score: 250.66  E-value: 3.92e-80
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6689089  300 IIGGQPAKPGDFPWQVLL---LGETTAAGALIHDDWVLTAAHAVYGKteAMSSLDIRMGILKRLSLIYTQ--AWPEAVFI 374
Cdd:cd00190   1 IVGGSEAKIGSFPWQVSLqytGGRHFCGGSLISPRWVLTAAHCVYSS--APSNYTVRLGSHDLSSNEGGGqvIKVKKVIV 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6689089  375 HEGYtHGAGFDNDIALIKLKNKVTINRNIMPICLPRKEaaSLMKTDFVGTVAGWGLTQ-KGFLARNLMFVDIPIVDHQKC 453
Cdd:cd00190  79 HPNY-NPSTYDNDIALLKLKRPVTLSDNVRPICLPSSG--YNLPAGTTCTVSGWGRTSeGGPLPDVLQEVNVPIVSNAEC 155

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6689089  454 ATAYtkqpYPGAKVTVNMLCAGLDRGGKDSCRGDSGGALVFLDNEtqRWFVGGIVSWGSiNCGGSEQYGVYTKVTNYIPW 533
Cdd:cd00190 156 KRAY----SYGGTITDNMLCAGGLEGGKDACQGDSGGPLVCNDNG--RGVLVGIVSWGS-GCARPNYPGVYTRVSSYLDW 228


                ....
gi 6689089  534 IENI 537
Cdd:cd00190 229 IQKT 232
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 40-151 1.66e-31

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


:

Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 117.51  E-value: 1.66e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6689089   40 CSGQVFTGRSGFLSSPEYPQPYPKLSSCAYNIRLEEGFSITLDFvESFDVEMHPeaQCPYDSLKI----QTDKREYGPFC 115
Cdd:cd00041   1 CGGTLTASTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTF-EDFDLESSP--NCSYDYLEIydgpSTSSPLLGRFC 77

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 6689089  116 GKTLPPRIETDSNKVTITFTTDESGNHTGWKIHYTS 151
Cdd:cd00041  78 GSTLPPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113
Sushi pfam00084
Sushi repeat (SCR repeat);
156-217 4.59e-11

Sushi repeat (SCR repeat);


:

Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 58.28  E-value: 4.59e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6689089    156 CPDPTAPPNGHISPVQATYVLKDSFSVFCKTGFElLQGsvplkSFTAVCQKDGSWDRPIPEC 217
Cdd:pfam00084   1 CPPPPDIPNGKVSATKNEYNYGASVSYECDPGYR-LVG-----SPTITCQEDGTWSPPFPEC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
222-285 3.17e-08

Sushi repeat (SCR repeat);


:

Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 50.19  E-value: 3.17e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6689089    222 CGPPDDLPNGHVdyITGPEVTTYKAVIQYSCEETFYTMSSNgKYVCEADGFWTSSKgekslPVC 285
Cdd:pfam00084   1 CPPPPDIPNGKV--SATKNEYNYGASVSYECDPGYRLVGSP-TITCQEDGTWSPPF-----PEC 56
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 8-36 7.94e-07

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 45.70  E-value: 7.94e-07
                          10        20
                  ....*....|....*....|....*....
gi 6689089      8 CDHYCHNYLGGYYCSCRVGYILHQNKHTC 36
Cdd:pfam14670   8 CSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
 
Name Accession Description Interval E-value
Tryp_SPc cd00190
Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens ...
 300-537 3.92e-80

Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad residues.


Pssm-ID: 238113 [Multi-domain]  Cd Length: 232  Bit Score: 250.66  E-value: 3.92e-80
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6689089  300 IIGGQPAKPGDFPWQVLL---LGETTAAGALIHDDWVLTAAHAVYGKteAMSSLDIRMGILKRLSLIYTQ--AWPEAVFI 374
Cdd:cd00190   1 IVGGSEAKIGSFPWQVSLqytGGRHFCGGSLISPRWVLTAAHCVYSS--APSNYTVRLGSHDLSSNEGGGqvIKVKKVIV 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6689089  375 HEGYtHGAGFDNDIALIKLKNKVTINRNIMPICLPRKEaaSLMKTDFVGTVAGWGLTQ-KGFLARNLMFVDIPIVDHQKC 453
Cdd:cd00190  79 HPNY-NPSTYDNDIALLKLKRPVTLSDNVRPICLPSSG--YNLPAGTTCTVSGWGRTSeGGPLPDVLQEVNVPIVSNAEC 155

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6689089  454 ATAYtkqpYPGAKVTVNMLCAGLDRGGKDSCRGDSGGALVFLDNEtqRWFVGGIVSWGSiNCGGSEQYGVYTKVTNYIPW 533
Cdd:cd00190 156 KRAY----SYGGTITDNMLCAGGLEGGKDACQGDSGGPLVCNDNG--RGVLVGIVSWGS-GCARPNYPGVYTRVSSYLDW 228


                ....
gi 6689089  534 IENI 537
Cdd:cd00190 229 IQKT 232
Tryp_SPc smart00020
Trypsin-like serine protease; Many of these are synthesised as inactive precursor zymogens ...
 299-534 1.31e-79

Trypsin-like serine protease; Many of these are synthesised as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. A few, however, are active as single chain molecules, and others are inactive due to substitutions of the catalytic triad residues.


Pssm-ID: 214473  Cd Length: 229  Bit Score: 249.13  E-value: 1.31e-79
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6689089     299 RIIGGQPAKPGDFPWQVLLL---GETTAAGALIHDDWVLTAAHAVYGKTEamSSLDIRMGILKRLSLIYTQAWP-EAVFI 374
Cdd:smart00020   1 RIVGGSEANIGSFPWQVSLQyggGRHFCGGSLISPRWVLTAAHCVRGSDP--SNIRVRLGSHDLSSGEEGQVIKvSKVII 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6689089     375 HEGYtHGAGFDNDIALIKLKNKVTINRNIMPICLPRKeaASLMKTDFVGTVAGWGLTQ--KGFLARNLMFVDIPIVDHQK 452
Cdd:smart00020  79 HPNY-NPSTYDNDIALLKLKEPVTLSDNVRPICLPSS--NYNVPAGTTCTVSGWGRTSegAGSLPDTLQEVNVPIVSNAT 155

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6689089     453 CATAYtkqpYPGAKVTVNMLCAGLDRGGKDSCRGDSGGALVFLDNetqRWFVGGIVSWGSiNCGGSEQYGVYTKVTNYIP 532
Cdd:smart00020 156 CRRAY----SGGGAITDNMLCAGGLEGGKDACQGDSGGPLVCNDG---RWVLVGIVSWGS-GCARPGKPGVYTRVSSYLD 227


                   ..
gi 6689089     533 WI 534
Cdd:smart00020 228 WI 229
Trypsin pfam00089
Trypsin;
300-534 6.91e-57

Trypsin;


Pssm-ID: 459667 [Multi-domain]  Cd Length: 219  Bit Score: 189.58  E-value: 6.91e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6689089    300 IIGGQPAKPGDFPWQVLLL---GETTAAGALIHDDWVLTAAHAVYGKTEA-----MSSLDIRMGILKRLSLiytqawpEA 371
Cdd:pfam00089   1 IVGGDEAQPGSFPWQVSLQlssGKHFCGGSLISENWVLTAAHCVSGASDVkvvlgAHNIVLREGGEQKFDV-------EK 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6689089    372 VFIHEGYThGAGFDNDIALIKLKNKVTINRNIMPICLPRKEAASLMKTdfVGTVAGWGLTQKGFLARNLMFVDIPIVDHQ 451
Cdd:pfam00089  74 IIVHPNYN-PDTLDNDIALLKLESPVTLGDTVRPICLPDASSDLPVGT--TCTVSGWGNTKTLGPSDTLQEVTVPVVSRE 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6689089    452 KCATAYtkqpypGAKVTVNMLCAGLdrGGKDSCRGDSGGALVFLDNETQrwfvgGIVSWGsINCGGSEQYGVYTKVTNYI 531
Cdd:pfam00089 151 TCRSAY------GGTVTDTMICAGA--GGKDACQGDSGGPLVCSDGELI-----GIVSWG-YGCASGNYPGVYTPVSSYL 216


                  ...
gi 6689089    532 PWI 534
Cdd:pfam00089 217 DWI 219
COG5640 COG5640
Secreted trypsin-like serine protease [Posttranslational modification, protein turnover, ...
 287-539 1.02e-55

Secreted trypsin-like serine protease [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 444365 [Multi-domain]  Cd Length: 262  Bit Score: 187.93  E-value: 1.02e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6689089  287 PVCGLSTHTSGGRIIGGQPAKPGDFPWQVLLLGETTAA-----GALIHDDWVLTAAHAVYGktEAMSSLDIRMGILKRLS 361
Cdd:COG5640  18 ALAAAPAADAAPAIVGGTPATVGEYPWMVALQSSNGPSgqfcgGTLIAPRWVLTAAHCVDG--DGPSDLRVVIGSTDLST 95

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6689089  362 LIYTQAWPEAVFIHEGYThGAGFDNDIALIKLKNKVTinrNIMPICLPrkEAASLMKTDFVGTVAGWGLT--QKGFLARN 439
Cdd:COG5640  96 SGGTVVKVARIVVHPDYD-PATPGNDIALLKLATPVP---GVAPAPLA--TSADAAAPGTPATVAGWGRTseGPGSQSGT 169

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6689089  440 LMFVDIPIVDHQKCATaytkqpYPGAkVTVNMLCAGLDRGGKDSCRGDSGGALVFLDNEtqRWFVGGIVSWGSINCGGSe 519
Cdd:COG5640 170 LRKADVPVVSDATCAA------YGGF-DGGTMLCAGYPEGGKDACQGDSGGPLVVKDGG--GWVLVGVVSWGGGPCAAG- 239

                       250       260
                ....*....|....*....|
gi 6689089  520 QYGVYTKVTNYIPWIENIIN 539
Cdd:COG5640 240 YPGVYTRVSAYRDWIKSTAG 259
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 40-151 1.66e-31

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 117.51  E-value: 1.66e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6689089   40 CSGQVFTGRSGFLSSPEYPQPYPKLSSCAYNIRLEEGFSITLDFvESFDVEMHPeaQCPYDSLKI----QTDKREYGPFC 115
Cdd:cd00041   1 CGGTLTASTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTF-EDFDLESSP--NCSYDYLEIydgpSTSSPLLGRFC 77

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 6689089  116 GKTLPPRIETDSNKVTITFTTDESGNHTGWKIHYTS 151
Cdd:cd00041  78 GSTLPPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113
CUB pfam00431
CUB domain;
40-149 2.81e-29

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 111.23  E-value: 2.81e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6689089     40 CSGqVFTGRSGFLSSPEYPQPYPKLSSCAYNIRLEEGFSITLDFvESFDVEMHPEaqCPYDSLKIQ----TDKREYGPFC 115
Cdd:pfam00431   1 CGG-VLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTF-QDFELEDHDE--CGYDYVEIRdgpsASSPLLGRFC 76

                          90       100       110
                  ....*....|....*....|....*....|....
gi 6689089    116 GKTLPPRIETDSNKVTITFTTDESGNHTGWKIHY 149
Cdd:pfam00431  77 GSGIPEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 50-149 2.67e-26

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 102.85  E-value: 2.67e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6689089      50 GFLSSPEYPQPYPKLSSCAYNIRLEEGFSITLDFvESFDVEMHPEaqCPYDSLKIQ----TDKREYGPFCGKTLPPR-IE 124
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQF-TDFDLESSDN--CEYDYVEIYdgpsASSPLLGRFCGSEAPPPvIS 77

                           90       100
                   ....*....|....*....|....*
gi 6689089     125 TDSNKVTITFTTDESGNHTGWKIHY 149
Cdd:smart00042  78 SSSNSLTLTFVSDSSVQKRGFSARY 102
Sushi pfam00084
Sushi repeat (SCR repeat);
156-217 4.59e-11

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 58.28  E-value: 4.59e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6689089    156 CPDPTAPPNGHISPVQATYVLKDSFSVFCKTGFElLQGsvplkSFTAVCQKDGSWDRPIPEC 217
Cdd:pfam00084   1 CPPPPDIPNGKVSATKNEYNYGASVSYECDPGYR-LVG-----SPTITCQEDGTWSPPFPEC 56
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 156-217 1.84e-10

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 56.38  E-value: 1.84e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6689089     156 CPDPTAPPNGHISPVQATYVLKDSFSVFCKTGFELLQGSvplksfTAVCQKDGSWDRPIPEC 217
Cdd:smart00032   1 CPPPPDIENGTVTSSSGTYSYGDTVTYSCDPGYTLIGSS------TITCLENGTWSPPPPTC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 156-217 2.14e-10

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 56.32  E-value: 2.14e-10
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6689089  156 CPDPTAPPNGHISPVQATYVLKDSFSVFCKTGFELLQgsvplkSFTAVCQKDGSWDRPIPEC 217
Cdd:cd00033   1 CPPPPVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVG------SSTITCTENGGWSPPPPTC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
222-285 3.17e-08

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 50.19  E-value: 3.17e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6689089    222 CGPPDDLPNGHVdyITGPEVTTYKAVIQYSCEETFYTMSSNgKYVCEADGFWTSSKgekslPVC 285
Cdd:pfam00084   1 CPPPPDIPNGKV--SATKNEYNYGASVSYECDPGYRLVGSP-TITCQEDGTWSPPF-----PEC 56
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 8-36 7.94e-07

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 45.70  E-value: 7.94e-07
                          10        20
                  ....*....|....*....|....*....
gi 6689089      8 CDHYCHNYLGGYYCSCRVGYILHQNKHTC 36
Cdd:pfam14670   8 CSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 222-286 1.80e-06

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 45.15  E-value: 1.80e-06
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6689089  222 CGPPDDLPNGHVDYITGPevTTYKAVIQYSCEETfYTMSSNGKYVCEADGFWTSskgekSLPVCK 286
Cdd:cd00033   1 CPPPPVPENGTVTGSKGS--YSYGSTVTYSCNEG-YTLVGSSTITCTENGGWSP-----PPPTCE 57
PHA02817 PHA02817
EEV Host range protein; Provisional
 156-285 4.55e-06

EEV Host range protein; Provisional


Pssm-ID: 165167 [Multi-domain]  Cd Length: 225  Bit Score: 48.01  E-value: 4.55e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6689089   156 CPDPTAPPNGHISPVQATYVLKDSFSVFCKTGFELLQGSVpLKSFTAVCQKDGSWDRPIPECSIIDCGPPdDLPNGHVDY 235
Cdd:PHA02817  24 CCYPPSIKNGYIYNKKTEYNIGSNVTFFCGNNTRGVRYTL-VGEKNIICEKDGKWNKEFPVCKIIRCRFP-ALQNGFVNG 101

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 6689089   236 ITGPEVTTYKAVIQYSCEETFYTMSSngKY-VCEADGFWTSskgekSLPVC 285
Cdd:PHA02817 102 IPDSKKFYYESEVSFSCKPGFVLIGT--KYsVCGINSSWIP-----KVPIC 145
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 222-285 2.58e-05

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 41.74  E-value: 2.58e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6689089     222 CGPPDDLPNGHVDYITGPevTTYKAVIQYSCEETfYTMSSNGKYVCEADGFWTSskgekSLPVC 285
Cdd:smart00032   1 CPPPPDIENGTVTSSSGT--YSYGDTVTYSCDPG-YTLIGSSTITCLENGTWSP-----PPPTC 56
EGF_CA smart00179
Calcium-binding EGF-like domain;
7-32 4.57e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 34.92  E-value: 4.57e-03
                           10        20
                   ....*....|....*....|....*...
gi 6689089       7 PCDH--YCHNYLGGYYCSCRVGYILHQN 32
Cdd:smart00179  10 PCQNggTCVNTVGSYRCECPPGYTDGRN 37
 
Name Accession Description Interval E-value
Tryp_SPc cd00190
Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens ...
 300-537 3.92e-80

Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad residues.


Pssm-ID: 238113 [Multi-domain]  Cd Length: 232  Bit Score: 250.66  E-value: 3.92e-80
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6689089  300 IIGGQPAKPGDFPWQVLL---LGETTAAGALIHDDWVLTAAHAVYGKteAMSSLDIRMGILKRLSLIYTQ--AWPEAVFI 374
Cdd:cd00190   1 IVGGSEAKIGSFPWQVSLqytGGRHFCGGSLISPRWVLTAAHCVYSS--APSNYTVRLGSHDLSSNEGGGqvIKVKKVIV 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6689089  375 HEGYtHGAGFDNDIALIKLKNKVTINRNIMPICLPRKEaaSLMKTDFVGTVAGWGLTQ-KGFLARNLMFVDIPIVDHQKC 453
Cdd:cd00190  79 HPNY-NPSTYDNDIALLKLKRPVTLSDNVRPICLPSSG--YNLPAGTTCTVSGWGRTSeGGPLPDVLQEVNVPIVSNAEC 155

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6689089  454 ATAYtkqpYPGAKVTVNMLCAGLDRGGKDSCRGDSGGALVFLDNEtqRWFVGGIVSWGSiNCGGSEQYGVYTKVTNYIPW 533
Cdd:cd00190 156 KRAY----SYGGTITDNMLCAGGLEGGKDACQGDSGGPLVCNDNG--RGVLVGIVSWGS-GCARPNYPGVYTRVSSYLDW 228


                ....
gi 6689089  534 IENI 537
Cdd:cd00190 229 IQKT 232
Tryp_SPc smart00020
Trypsin-like serine protease; Many of these are synthesised as inactive precursor zymogens ...
 299-534 1.31e-79

Trypsin-like serine protease; Many of these are synthesised as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. A few, however, are active as single chain molecules, and others are inactive due to substitutions of the catalytic triad residues.


Pssm-ID: 214473  Cd Length: 229  Bit Score: 249.13  E-value: 1.31e-79
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6689089     299 RIIGGQPAKPGDFPWQVLLL---GETTAAGALIHDDWVLTAAHAVYGKTEamSSLDIRMGILKRLSLIYTQAWP-EAVFI 374
Cdd:smart00020   1 RIVGGSEANIGSFPWQVSLQyggGRHFCGGSLISPRWVLTAAHCVRGSDP--SNIRVRLGSHDLSSGEEGQVIKvSKVII 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6689089     375 HEGYtHGAGFDNDIALIKLKNKVTINRNIMPICLPRKeaASLMKTDFVGTVAGWGLTQ--KGFLARNLMFVDIPIVDHQK 452
Cdd:smart00020  79 HPNY-NPSTYDNDIALLKLKEPVTLSDNVRPICLPSS--NYNVPAGTTCTVSGWGRTSegAGSLPDTLQEVNVPIVSNAT 155

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6689089     453 CATAYtkqpYPGAKVTVNMLCAGLDRGGKDSCRGDSGGALVFLDNetqRWFVGGIVSWGSiNCGGSEQYGVYTKVTNYIP 532
Cdd:smart00020 156 CRRAY----SGGGAITDNMLCAGGLEGGKDACQGDSGGPLVCNDG---RWVLVGIVSWGS-GCARPGKPGVYTRVSSYLD 227


                   ..
gi 6689089     533 WI 534
Cdd:smart00020 228 WI 229
Trypsin pfam00089
Trypsin;
300-534 6.91e-57

Trypsin;


Pssm-ID: 459667 [Multi-domain]  Cd Length: 219  Bit Score: 189.58  E-value: 6.91e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6689089    300 IIGGQPAKPGDFPWQVLLL---GETTAAGALIHDDWVLTAAHAVYGKTEA-----MSSLDIRMGILKRLSLiytqawpEA 371
Cdd:pfam00089   1 IVGGDEAQPGSFPWQVSLQlssGKHFCGGSLISENWVLTAAHCVSGASDVkvvlgAHNIVLREGGEQKFDV-------EK 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6689089    372 VFIHEGYThGAGFDNDIALIKLKNKVTINRNIMPICLPRKEAASLMKTdfVGTVAGWGLTQKGFLARNLMFVDIPIVDHQ 451
Cdd:pfam00089  74 IIVHPNYN-PDTLDNDIALLKLESPVTLGDTVRPICLPDASSDLPVGT--TCTVSGWGNTKTLGPSDTLQEVTVPVVSRE 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6689089    452 KCATAYtkqpypGAKVTVNMLCAGLdrGGKDSCRGDSGGALVFLDNETQrwfvgGIVSWGsINCGGSEQYGVYTKVTNYI 531
Cdd:pfam00089 151 TCRSAY------GGTVTDTMICAGA--GGKDACQGDSGGPLVCSDGELI-----GIVSWG-YGCASGNYPGVYTPVSSYL 216


                  ...
gi 6689089    532 PWI 534
Cdd:pfam00089 217 DWI 219
COG5640 COG5640
Secreted trypsin-like serine protease [Posttranslational modification, protein turnover, ...
 287-539 1.02e-55

Secreted trypsin-like serine protease [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 444365 [Multi-domain]  Cd Length: 262  Bit Score: 187.93  E-value: 1.02e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6689089  287 PVCGLSTHTSGGRIIGGQPAKPGDFPWQVLLLGETTAA-----GALIHDDWVLTAAHAVYGktEAMSSLDIRMGILKRLS 361
Cdd:COG5640  18 ALAAAPAADAAPAIVGGTPATVGEYPWMVALQSSNGPSgqfcgGTLIAPRWVLTAAHCVDG--DGPSDLRVVIGSTDLST 95

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6689089  362 LIYTQAWPEAVFIHEGYThGAGFDNDIALIKLKNKVTinrNIMPICLPrkEAASLMKTDFVGTVAGWGLT--QKGFLARN 439
Cdd:COG5640  96 SGGTVVKVARIVVHPDYD-PATPGNDIALLKLATPVP---GVAPAPLA--TSADAAAPGTPATVAGWGRTseGPGSQSGT 169

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6689089  440 LMFVDIPIVDHQKCATaytkqpYPGAkVTVNMLCAGLDRGGKDSCRGDSGGALVFLDNEtqRWFVGGIVSWGSINCGGSe 519
Cdd:COG5640 170 LRKADVPVVSDATCAA------YGGF-DGGTMLCAGYPEGGKDACQGDSGGPLVVKDGG--GWVLVGVVSWGGGPCAAG- 239

                       250       260
                ....*....|....*....|
gi 6689089  520 QYGVYTKVTNYIPWIENIIN 539
Cdd:COG5640 240 YPGVYTRVSAYRDWIKSTAG 259
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 40-151 1.66e-31

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 117.51  E-value: 1.66e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6689089   40 CSGQVFTGRSGFLSSPEYPQPYPKLSSCAYNIRLEEGFSITLDFvESFDVEMHPeaQCPYDSLKI----QTDKREYGPFC 115
Cdd:cd00041   1 CGGTLTASTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTF-EDFDLESSP--NCSYDYLEIydgpSTSSPLLGRFC 77

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 6689089  116 GKTLPPRIETDSNKVTITFTTDESGNHTGWKIHYTS 151
Cdd:cd00041  78 GSTLPPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113
CUB pfam00431
CUB domain;
40-149 2.81e-29

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 111.23  E-value: 2.81e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6689089     40 CSGqVFTGRSGFLSSPEYPQPYPKLSSCAYNIRLEEGFSITLDFvESFDVEMHPEaqCPYDSLKIQ----TDKREYGPFC 115
Cdd:pfam00431   1 CGG-VLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTF-QDFELEDHDE--CGYDYVEIRdgpsASSPLLGRFC 76

                          90       100       110
                  ....*....|....*....|....*....|....
gi 6689089    116 GKTLPPRIETDSNKVTITFTTDESGNHTGWKIHY 149
Cdd:pfam00431  77 GSGIPEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 50-149 2.67e-26

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 102.85  E-value: 2.67e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6689089      50 GFLSSPEYPQPYPKLSSCAYNIRLEEGFSITLDFvESFDVEMHPEaqCPYDSLKIQ----TDKREYGPFCGKTLPPR-IE 124
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQF-TDFDLESSDN--CEYDYVEIYdgpsASSPLLGRFCGSEAPPPvIS 77

                           90       100
                   ....*....|....*....|....*
gi 6689089     125 TDSNKVTITFTTDESGNHTGWKIHY 149
Cdd:smart00042  78 SSSNSLTLTFVSDSSVQKRGFSARY 102
Sushi pfam00084
Sushi repeat (SCR repeat);
156-217 4.59e-11

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 58.28  E-value: 4.59e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6689089    156 CPDPTAPPNGHISPVQATYVLKDSFSVFCKTGFElLQGsvplkSFTAVCQKDGSWDRPIPEC 217
Cdd:pfam00084   1 CPPPPDIPNGKVSATKNEYNYGASVSYECDPGYR-LVG-----SPTITCQEDGTWSPPFPEC 56
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 156-217 1.84e-10

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 56.38  E-value: 1.84e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6689089     156 CPDPTAPPNGHISPVQATYVLKDSFSVFCKTGFELLQGSvplksfTAVCQKDGSWDRPIPEC 217
Cdd:smart00032   1 CPPPPDIENGTVTSSSGTYSYGDTVTYSCDPGYTLIGSS------TITCLENGTWSPPPPTC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 156-217 2.14e-10

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 56.32  E-value: 2.14e-10
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6689089  156 CPDPTAPPNGHISPVQATYVLKDSFSVFCKTGFELLQgsvplkSFTAVCQKDGSWDRPIPEC 217
Cdd:cd00033   1 CPPPPVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVG------SSTITCTENGGWSPPPPTC 56
eMpr COG3591
V8-like Glu-specific endopeptidase [Posttranslational modification, protein turnover, ...
 325-518 2.45e-08

V8-like Glu-specific endopeptidase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442810 [Multi-domain]  Cd Length: 194  Bit Score: 54.30  E-value: 2.45e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6689089  325 GALIHDDWVLTAAHAVYGKTEA--MSSLDIRMGilkRLSLIYTQAWPEAVFIHEGYTHGAGFDNDIALIKLKNKVTINRN 402
Cdd:COG3591  16 GTLIGPNLVLTAGHCVYDGAGGgwATNIVFVPG---YNGGPYGTATATRFRVPPGWVASGDAGYDYALLRLDEPLGDTTG 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6689089  403 IMPIclprKEAASLMKTDFVgTVAGWGLTQKGFLARnlmfvdipivdHQKCATAYTKQPypgakvTVNMLCagldrggkD 482
Cdd:COG3591  93 WLGL----AFNDAPLAGEPV-TIIGYPGDRPKDLSL-----------DCSGRVTGVQGN------RLSYDC--------D 142

                       170       180       190
                ....*....|....*....|....*....|....*.
gi 6689089  483 SCRGDSGGALvfLDNETQRWFVGGIVSWGSINCGGS 518
Cdd:COG3591 143 TTGGSSGSPV--LDDSDGGGRVVGVHSAGGADRANT 176
Sushi pfam00084
Sushi repeat (SCR repeat);
222-285 3.17e-08

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 50.19  E-value: 3.17e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6689089    222 CGPPDDLPNGHVdyITGPEVTTYKAVIQYSCEETFYTMSSNgKYVCEADGFWTSSKgekslPVC 285
Cdd:pfam00084   1 CPPPPDIPNGKV--SATKNEYNYGASVSYECDPGYRLVGSP-TITCQEDGTWSPPF-----PEC 56
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 8-36 7.94e-07

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 45.70  E-value: 7.94e-07
                          10        20
                  ....*....|....*....|....*....
gi 6689089      8 CDHYCHNYLGGYYCSCRVGYILHQNKHTC 36
Cdd:pfam14670   8 CSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 222-286 1.80e-06

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 45.15  E-value: 1.80e-06
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6689089  222 CGPPDDLPNGHVDYITGPevTTYKAVIQYSCEETfYTMSSNGKYVCEADGFWTSskgekSLPVCK 286
Cdd:cd00033   1 CPPPPVPENGTVTGSKGS--YSYGSTVTYSCNEG-YTLVGSSTITCTENGGWSP-----PPPTCE 57
PHA02817 PHA02817
EEV Host range protein; Provisional
 156-285 4.55e-06

EEV Host range protein; Provisional


Pssm-ID: 165167 [Multi-domain]  Cd Length: 225  Bit Score: 48.01  E-value: 4.55e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6689089   156 CPDPTAPPNGHISPVQATYVLKDSFSVFCKTGFELLQGSVpLKSFTAVCQKDGSWDRPIPECSIIDCGPPdDLPNGHVDY 235
Cdd:PHA02817  24 CCYPPSIKNGYIYNKKTEYNIGSNVTFFCGNNTRGVRYTL-VGEKNIICEKDGKWNKEFPVCKIIRCRFP-ALQNGFVNG 101

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 6689089   236 ITGPEVTTYKAVIQYSCEETFYTMSSngKY-VCEADGFWTSskgekSLPVC 285
Cdd:PHA02817 102 IPDSKKFYYESEVSFSCKPGFVLIGT--KYsVCGINSSWIP-----KVPIC 145
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 222-285 2.58e-05

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 41.74  E-value: 2.58e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6689089     222 CGPPDDLPNGHVDYITGPevTTYKAVIQYSCEETfYTMSSNGKYVCEADGFWTSskgekSLPVC 285
Cdd:smart00032   1 CPPPPDIENGTVTSSSGT--YSYGDTVTYSCDPG-YTLIGSSTITCLENGTWSP-----PPPTC 56
PHA02639 PHA02639
EEV host range protein; Provisional
 154-288 3.85e-04

EEV host range protein; Provisional


Pssm-ID: 165022 [Multi-domain]  Cd Length: 295  Bit Score: 42.73  E-value: 3.85e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6689089   154 QPCPDPTAPPNGHISPVQATYVLKDSFSVFCKTGFELLQGSVPLKSFTavCQKDGSWDRPIPECSIIDCGPPdDLPNGHV 233
Cdd:PHA02639  83 KECNDPPSIINGKIYNKREMYKVGDEIYYVCNEHKGVQYSLVGNEKIT--CIQDKSWKPDPPICKMINCRFP-ALQNGYI 159

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 6689089   234 DYITGPEVTTYKAVIQYSCEETFYTMSSngKY-VCEADGFWTSskgekSLPVC---KPV 288
Cdd:PHA02639 160 NGIPSNKKFYYKTRVGFSCKSGFDLVGE--KYsTCNINATWFP-----SIPTCvrnKPI 211
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 143-297 4.30e-04

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 42.33  E-value: 4.30e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6689089   143 TGWKIHYTSTAQPCPDPTAPPNGHISPVQATYvlKDSFSVFCKTGFELLQGSvplKSFTAVcQKDGS--WDRPIPECSII 220
Cdd:PHA02927  73 TGWTLFNQCIKRRCPSPRDIDNGQLDIGGVDF--GSSITYSCNSGYQLIGES---KSYCEL-GSTGSmvWNPEAPICESV 146

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6689089   221 DCGPPDDLPNG-HVDYitgPEVTTYKAVIQYSCeETFYTMSSNGKYVCEAdGFWTSSkgekslPVCKPV-CGLSTHTSG 297
Cdd:PHA02927 147 KCQSPPSISNGrHNGY---EDFYTDGSVVTYSC-NSGYSLIGNSGVLCSG-GEWSDP------PTCQIVkCPHPTISNG 214
EGF_CA smart00179
Calcium-binding EGF-like domain;
7-32 4.57e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 34.92  E-value: 4.57e-03
                           10        20
                   ....*....|....*....|....*...
gi 6689089       7 PCDH--YCHNYLGGYYCSCRVGYILHQN 32
Cdd:smart00179  10 PCQNggTCVNTVGSYRCECPPGYTDGRN 37
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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