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Conserved domains on  [gi|10190805|emb|CAB65879|]
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EG:BACR7A4.10 [Drosophila melanogaster]

Protein Classification

DRY_EERY and SWAP domain-containing protein( domain architecture ID 10560971)

DRY_EERY and SWAP domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DRY_EERY pfam09750
Alternative splicing regulator; This entry represents the conserved N-terminal region of SWAP ...
 60-249 7.92e-28

Alternative splicing regulator; This entry represents the conserved N-terminal region of SWAP (suppressor-of-white-apricot protein) proteins. This region contains two highly conserved motifs, viz: DRY and EERY, which appear to be the sites for alternative splicing of exons 2 and 3 of the SWAP mRNA. These proteins are thus thought to be involved in auto-regulation of pre-mRNA splicing. Most family members are associated with two Surp domains pfam01805 and an Arginine- serine-rich binding region towards the C-terminus.


:

Pssm-ID: 462881  Cd Length: 129  Bit Score: 109.33  E-value: 7.92e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10190805     60 LLVFGYACKIFRDDEKAREMDHGKQLIPWMGDVNLKIDRliigtnpsnnytinqyahhchkhthtatyppmscpvrttlp 139
Cdd:pfam09750    1 LQVFGRRCKLFRDDAIAAAAESGKHLVPWQGDPDLLIDR----------------------------------------- 39

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10190805    140 htaavkllaesdtyiyvgividgivimaYDVRGALCELAPHEAppgGYGNRLEYLSAEEQRAEQLCEEERYLFLYNNEEE 219
Cdd:pfam09750   40 ----------------------------FDVRALLDDIPEYEA---GRSARLSELTSEEEEEERECNYERYRDLIKNEFE 88

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|..
gi 10190805    220 LRLRQEEdLKRLQQE------------TSGGCFSQVGFQYDG 249
Cdd:pfam09750   89 GVSEEEE-LKRIYQEeqfgakrlsaakKSSGSYAAIGFSYDD 129
SWAP smart00648
Suppressor-of-White-APricot splicing regulator; domain present in regulators which are ...
 301-353 1.25e-15

Suppressor-of-White-APricot splicing regulator; domain present in regulators which are responsible for pre-mRNA splicing processes


:

Pssm-ID: 197818 [Multi-domain]  Cd Length: 54  Bit Score: 71.85  E-value: 1.25e-15
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 10190805     301 HAIIEKTARFIATQGAQMEILIKAKQANNTQFDFLTQGGHLQPYYRHLLAAIK 353
Cdd:smart00648    1 LDIIDKTAQFVARNGPEFEAKLMERERNNPQFDFLKPNDPYHAYYRKKLAEYR 53
SWAP smart00648
Suppressor-of-White-APricot splicing regulator; domain present in regulators which are ...
 550-596 4.54e-15

Suppressor-of-White-APricot splicing regulator; domain present in regulators which are responsible for pre-mRNA splicing processes


:

Pssm-ID: 197818 [Multi-domain]  Cd Length: 54  Bit Score: 70.31  E-value: 4.54e-15
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*....
gi 10190805     550 RHIIDKTATYVIKNGRQFEETLRTKSVD--RFSFLLPANEYYPYYLYKV 596
Cdd:smart00648    1 LDIIDKTAQFVARNGPEFEAKLMERERNnpQFDFLKPNDPYHAYYRKKL 49
 
Name Accession Description Interval E-value
DRY_EERY pfam09750
Alternative splicing regulator; This entry represents the conserved N-terminal region of SWAP ...
 60-249 7.92e-28

Alternative splicing regulator; This entry represents the conserved N-terminal region of SWAP (suppressor-of-white-apricot protein) proteins. This region contains two highly conserved motifs, viz: DRY and EERY, which appear to be the sites for alternative splicing of exons 2 and 3 of the SWAP mRNA. These proteins are thus thought to be involved in auto-regulation of pre-mRNA splicing. Most family members are associated with two Surp domains pfam01805 and an Arginine- serine-rich binding region towards the C-terminus.


Pssm-ID: 462881  Cd Length: 129  Bit Score: 109.33  E-value: 7.92e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10190805     60 LLVFGYACKIFRDDEKAREMDHGKQLIPWMGDVNLKIDRliigtnpsnnytinqyahhchkhthtatyppmscpvrttlp 139
Cdd:pfam09750    1 LQVFGRRCKLFRDDAIAAAAESGKHLVPWQGDPDLLIDR----------------------------------------- 39

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10190805    140 htaavkllaesdtyiyvgividgivimaYDVRGALCELAPHEAppgGYGNRLEYLSAEEQRAEQLCEEERYLFLYNNEEE 219
Cdd:pfam09750   40 ----------------------------FDVRALLDDIPEYEA---GRSARLSELTSEEEEEERECNYERYRDLIKNEFE 88

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|..
gi 10190805    220 LRLRQEEdLKRLQQE------------TSGGCFSQVGFQYDG 249
Cdd:pfam09750   89 GVSEEEE-LKRIYQEeqfgakrlsaakKSSGSYAAIGFSYDD 129
SWAP smart00648
Suppressor-of-White-APricot splicing regulator; domain present in regulators which are ...
 301-353 1.25e-15

Suppressor-of-White-APricot splicing regulator; domain present in regulators which are responsible for pre-mRNA splicing processes


Pssm-ID: 197818 [Multi-domain]  Cd Length: 54  Bit Score: 71.85  E-value: 1.25e-15
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 10190805     301 HAIIEKTARFIATQGAQMEILIKAKQANNTQFDFLTQGGHLQPYYRHLLAAIK 353
Cdd:smart00648    1 LDIIDKTAQFVARNGPEFEAKLMERERNNPQFDFLKPNDPYHAYYRKKLAEYR 53
Surp pfam01805
Surp module; This domain is also known as the SWAP domain. SWAP stands for ...
 302-352 2.98e-15

Surp module; This domain is also known as the SWAP domain. SWAP stands for Suppressor-of-White-APricot. It has been suggested that these domains may be RNA binding.


Pssm-ID: 460339 [Multi-domain]  Cd Length: 52  Bit Score: 70.63  E-value: 2.98e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 10190805    302 AIIEKTARFIATQGAQMEILIKAKQANNTQFDFLTQGGH-LQPYYRHLLAAI 352
Cdd:pfam01805    1 DIIKKTAQFVARNGPEFEALLMEREERNPQFDFLFDPDDpLHAYYRWKLEEY 52
SWAP smart00648
Suppressor-of-White-APricot splicing regulator; domain present in regulators which are ...
 550-596 4.54e-15

Suppressor-of-White-APricot splicing regulator; domain present in regulators which are responsible for pre-mRNA splicing processes


Pssm-ID: 197818 [Multi-domain]  Cd Length: 54  Bit Score: 70.31  E-value: 4.54e-15
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*....
gi 10190805     550 RHIIDKTATYVIKNGRQFEETLRTKSVD--RFSFLLPANEYYPYYLYKV 596
Cdd:smart00648    1 LDIIDKTAQFVARNGPEFEAKLMERERNnpQFDFLKPNDPYHAYYRKKL 49
Surp pfam01805
Surp module; This domain is also known as the SWAP domain. SWAP stands for ...
 552-596 6.86e-12

Surp module; This domain is also known as the SWAP domain. SWAP stands for Suppressor-of-White-APricot. It has been suggested that these domains may be RNA binding.


Pssm-ID: 460339 [Multi-domain]  Cd Length: 52  Bit Score: 61.00  E-value: 6.86e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 10190805    552 IIDKTATYVIKNGRQFEETLRTKSVD--RFSFLLPAN-EYYPYYLYKV 596
Cdd:pfam01805    2 IIKKTAQFVARNGPEFEALLMEREERnpQFDFLFDPDdPLHAYYRWKL 49
 
Name Accession Description Interval E-value
DRY_EERY pfam09750
Alternative splicing regulator; This entry represents the conserved N-terminal region of SWAP ...
 60-249 7.92e-28

Alternative splicing regulator; This entry represents the conserved N-terminal region of SWAP (suppressor-of-white-apricot protein) proteins. This region contains two highly conserved motifs, viz: DRY and EERY, which appear to be the sites for alternative splicing of exons 2 and 3 of the SWAP mRNA. These proteins are thus thought to be involved in auto-regulation of pre-mRNA splicing. Most family members are associated with two Surp domains pfam01805 and an Arginine- serine-rich binding region towards the C-terminus.


Pssm-ID: 462881  Cd Length: 129  Bit Score: 109.33  E-value: 7.92e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10190805     60 LLVFGYACKIFRDDEKAREMDHGKQLIPWMGDVNLKIDRliigtnpsnnytinqyahhchkhthtatyppmscpvrttlp 139
Cdd:pfam09750    1 LQVFGRRCKLFRDDAIAAAAESGKHLVPWQGDPDLLIDR----------------------------------------- 39

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10190805    140 htaavkllaesdtyiyvgividgivimaYDVRGALCELAPHEAppgGYGNRLEYLSAEEQRAEQLCEEERYLFLYNNEEE 219
Cdd:pfam09750   40 ----------------------------FDVRALLDDIPEYEA---GRSARLSELTSEEEEEERECNYERYRDLIKNEFE 88

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|..
gi 10190805    220 LRLRQEEdLKRLQQE------------TSGGCFSQVGFQYDG 249
Cdd:pfam09750   89 GVSEEEE-LKRIYQEeqfgakrlsaakKSSGSYAAIGFSYDD 129
SWAP smart00648
Suppressor-of-White-APricot splicing regulator; domain present in regulators which are ...
 301-353 1.25e-15

Suppressor-of-White-APricot splicing regulator; domain present in regulators which are responsible for pre-mRNA splicing processes


Pssm-ID: 197818 [Multi-domain]  Cd Length: 54  Bit Score: 71.85  E-value: 1.25e-15
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 10190805     301 HAIIEKTARFIATQGAQMEILIKAKQANNTQFDFLTQGGHLQPYYRHLLAAIK 353
Cdd:smart00648    1 LDIIDKTAQFVARNGPEFEAKLMERERNNPQFDFLKPNDPYHAYYRKKLAEYR 53
Surp pfam01805
Surp module; This domain is also known as the SWAP domain. SWAP stands for ...
 302-352 2.98e-15

Surp module; This domain is also known as the SWAP domain. SWAP stands for Suppressor-of-White-APricot. It has been suggested that these domains may be RNA binding.


Pssm-ID: 460339 [Multi-domain]  Cd Length: 52  Bit Score: 70.63  E-value: 2.98e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 10190805    302 AIIEKTARFIATQGAQMEILIKAKQANNTQFDFLTQGGH-LQPYYRHLLAAI 352
Cdd:pfam01805    1 DIIKKTAQFVARNGPEFEALLMEREERNPQFDFLFDPDDpLHAYYRWKLEEY 52
SWAP smart00648
Suppressor-of-White-APricot splicing regulator; domain present in regulators which are ...
 550-596 4.54e-15

Suppressor-of-White-APricot splicing regulator; domain present in regulators which are responsible for pre-mRNA splicing processes


Pssm-ID: 197818 [Multi-domain]  Cd Length: 54  Bit Score: 70.31  E-value: 4.54e-15
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*....
gi 10190805     550 RHIIDKTATYVIKNGRQFEETLRTKSVD--RFSFLLPANEYYPYYLYKV 596
Cdd:smart00648    1 LDIIDKTAQFVARNGPEFEAKLMERERNnpQFDFLKPNDPYHAYYRKKL 49
Surp pfam01805
Surp module; This domain is also known as the SWAP domain. SWAP stands for ...
 552-596 6.86e-12

Surp module; This domain is also known as the SWAP domain. SWAP stands for Suppressor-of-White-APricot. It has been suggested that these domains may be RNA binding.


Pssm-ID: 460339 [Multi-domain]  Cd Length: 52  Bit Score: 61.00  E-value: 6.86e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 10190805    552 IIDKTATYVIKNGRQFEETLRTKSVD--RFSFLLPAN-EYYPYYLYKV 596
Cdd:pfam01805    2 IIKKTAQFVARNGPEFEALLMEREERnpQFDFLFDPDdPLHAYYRWKL 49
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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