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Conserved domains on  [gi|6723428|emb|CAB66921|]
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RuvB DNA helicase-like protein [Arabidopsis thaliana]

Protein Classification

RuvB-like helicase( domain architecture ID 15918217)

RuvB-like helicase is a DNA helicase that plays an essential role in various complexes involved in fundamental processes such as transcription regulation, DNA damage response and apoptosis (via the chromatin remodelling complexes SWR1, INO80 and TIP60), maturation of small nuclear ribonucleoproteins, cellular development, cancer metastasis, and regulation of mitosis

EC:  3.6.4.12
Gene Ontology:  GO:0005524|GO:0003678|GO:0006259
PubMed:  10787406

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TIP49 pfam06068
TIP49 P-loop domain; This family consists of the C-terminal region of several eukaryotic and ...
 17-363 0e+00

TIP49 P-loop domain; This family consists of the C-terminal region of several eukaryotic and archaeal RuvB-like 1 (Pontin or TIP49a) and RuvB-like 2 (Reptin or TIP49b) proteins. The N-terminal domain contains the pfam00004 domain. In zebrafish, the liebeskummer (lik) mutation, causes development of hyperplastic embryonic hearts. lik encodes Reptin, a component of a DNA-stimulated ATPase complex. Beta-catenin and Pontin, a DNA-stimulated ATPase that is often part of complexes with Reptin, are in the same genetic pathways. The Reptin/Pontin ratio serves to regulate heart growth during development, at least in part via the beta-catenin pathway. TBP-interacting protein 49 (TIP49) was originally identified as a TBP-binding protein, and two related proteins are encoded by individual genes, tip49a and b. Although the function of this gene family has not been elucidated, they are supposed to play a critical role in nuclear events because they interact with various kinds of nuclear factors and have DNA helicase activities.TIP49a has been suggested to act as an autoantigen in some patients with autoimmune diseases.


:

Pssm-ID: 399217 [Multi-domain]  Cd Length: 347  Bit Score: 607.00  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6723428     17 RIGAHSHIRGLGLDSVLEPRAVSEGMVGQIKARKAAGVTLELIRDGKISGRAILIAGQPGTGKIAIAMGIAKSLGQETPF 96
Cdd:pfam06068   1 RISAHSHIRGLGLDEDGEARYVSGGLVGQEKAREAAGVIVEMIKEGKIAGRAVLIAGPPGTGKTALAIAISKELGEDTPF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6723428     97 TMIAGSEIFSLEMSKTEALTQAFRKAIGVRIKEETDVIEGEVVTISI---DRPASsGGSVKKTGKITMKTTDMESNFDLG 173
Cdd:pfam06068  81 TSISGSEVYSLEMKKTEALTQAFRKAIGVRIKEEKEVYEGEVVELEIeeaENPLS-GGKTIKGGKITLKTTKMEKTLKLG 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6723428    174 WKLIEPLDKEKVQSGDVIVLDRFCGKITKLGRSFTRSRDFDVmgSKTKFVQCPEGELEKRKEVLHSVTLHEIDVINSRTQ 253
Cdd:pfam06068 160 PKIYEQLQKEKVSAGDVIYIDKNTGRVKKLGRSFARATDFDL--EATEFVPCPKGEVHKRKEVVQTVTLHDIDVANARPQ 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6723428    254 GYLALFTGDTGEIRSETREQSDTKVAEWREEGKAEIVPGVLFIDEVHMLDIECFSFLNRALENDMSPILVVATNRGMTTI 333
Cdd:pfam06068 238 GILSLFSPKKGEITSELREEINKKVNKWIEEGKAEIVPGVLFIDEVHMLDIECFSFLNRALESDLAPIVILATNRGICTI 317

                         330       340       350
                  ....*....|....*....|....*....|
gi 6723428    334 RGTNQISAHGIPIDFLDRLLIITTQPYTQD 363
Cdd:pfam06068 318 RGTDIISPHGIPLDLLDRLLIITTEPYTRE 347
TIP49_C pfam17856
TIP49 AAA-lid domain; This family consists of the C-terminal region of several eukaryotic and ...
 368-433 6.76e-27

TIP49 AAA-lid domain; This family consists of the C-terminal region of several eukaryotic and archaeal RuvB-like 1 (Pontin or TIP49a) and RuvB-like 2 (Reptin or TIP49b) proteins. The N-terminal domain contains the pfam00004 domain. In zebrafish, the liebeskummer (lik) mutation, causes development of hyperplastic embryonic hearts. lik encodes Reptin, a component of a DNA-stimulated ATPase complex. Beta-catenin and Pontin, a DNA-stimulated ATPase that is often part of complexes with Reptin, are in the same genetic pathways. The Reptin/Pontin ratio serves to regulate heart growth during development, at least in part via the beta-catenin pathway. TBP-interacting protein 49 (TIP49) was originally identified as a TBP-binding protein, and two related proteins are encoded by individual genes, tip49a and b. Although the function of this gene family has not been elucidated, they are supposed to play a critical role in nuclear events because they interact with various kinds of nuclear factors and have DNA helicase activities.TIP49a has been suggested to act as an autoantigen in some patients with autoimmune diseases.


:

Pssm-ID: 436097 [Multi-domain]  Cd Length: 66  Bit Score: 102.72  E-value: 6.76e-27
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 6723428    368 ILEIRCQEEDVEMNEEAKQLLTLIGCNTSLRYAIHLINAAALACLKRKGKVVEIQDIERVYRLFLD 433
Cdd:pfam17856   1 ILKIRAQEEGVKIDEEALDLLAKIGTETSLRYAIQLLTPASILAKKRGGKEVEVQDVEEAYELFLD 66
 
Name Accession Description Interval E-value
TIP49 pfam06068
TIP49 P-loop domain; This family consists of the C-terminal region of several eukaryotic and ...
 17-363 0e+00

TIP49 P-loop domain; This family consists of the C-terminal region of several eukaryotic and archaeal RuvB-like 1 (Pontin or TIP49a) and RuvB-like 2 (Reptin or TIP49b) proteins. The N-terminal domain contains the pfam00004 domain. In zebrafish, the liebeskummer (lik) mutation, causes development of hyperplastic embryonic hearts. lik encodes Reptin, a component of a DNA-stimulated ATPase complex. Beta-catenin and Pontin, a DNA-stimulated ATPase that is often part of complexes with Reptin, are in the same genetic pathways. The Reptin/Pontin ratio serves to regulate heart growth during development, at least in part via the beta-catenin pathway. TBP-interacting protein 49 (TIP49) was originally identified as a TBP-binding protein, and two related proteins are encoded by individual genes, tip49a and b. Although the function of this gene family has not been elucidated, they are supposed to play a critical role in nuclear events because they interact with various kinds of nuclear factors and have DNA helicase activities.TIP49a has been suggested to act as an autoantigen in some patients with autoimmune diseases.


Pssm-ID: 399217 [Multi-domain]  Cd Length: 347  Bit Score: 607.00  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6723428     17 RIGAHSHIRGLGLDSVLEPRAVSEGMVGQIKARKAAGVTLELIRDGKISGRAILIAGQPGTGKIAIAMGIAKSLGQETPF 96
Cdd:pfam06068   1 RISAHSHIRGLGLDEDGEARYVSGGLVGQEKAREAAGVIVEMIKEGKIAGRAVLIAGPPGTGKTALAIAISKELGEDTPF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6723428     97 TMIAGSEIFSLEMSKTEALTQAFRKAIGVRIKEETDVIEGEVVTISI---DRPASsGGSVKKTGKITMKTTDMESNFDLG 173
Cdd:pfam06068  81 TSISGSEVYSLEMKKTEALTQAFRKAIGVRIKEEKEVYEGEVVELEIeeaENPLS-GGKTIKGGKITLKTTKMEKTLKLG 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6723428    174 WKLIEPLDKEKVQSGDVIVLDRFCGKITKLGRSFTRSRDFDVmgSKTKFVQCPEGELEKRKEVLHSVTLHEIDVINSRTQ 253
Cdd:pfam06068 160 PKIYEQLQKEKVSAGDVIYIDKNTGRVKKLGRSFARATDFDL--EATEFVPCPKGEVHKRKEVVQTVTLHDIDVANARPQ 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6723428    254 GYLALFTGDTGEIRSETREQSDTKVAEWREEGKAEIVPGVLFIDEVHMLDIECFSFLNRALENDMSPILVVATNRGMTTI 333
Cdd:pfam06068 238 GILSLFSPKKGEITSELREEINKKVNKWIEEGKAEIVPGVLFIDEVHMLDIECFSFLNRALESDLAPIVILATNRGICTI 317

                         330       340       350
                  ....*....|....*....|....*....|
gi 6723428    334 RGTNQISAHGIPIDFLDRLLIITTQPYTQD 363
Cdd:pfam06068 318 RGTDIISPHGIPLDLLDRLLIITTEPYTRE 347
TIP49 COG1224
DNA helicase TIP49, TBP-interacting protein [Transcription];
1-449 1.92e-174

DNA helicase TIP49, TBP-interacting protein [Transcription];


Pssm-ID: 440837 [Multi-domain]  Cd Length: 452  Bit Score: 497.19  E-value: 1.92e-174
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6723428    1 MAELRlsETRDLTRIERIGAHSHIRGLGLDSVLEPRAVSEGMVGQIKARKAAGVTLELIRDGKISGRAILIAGQPGTGKI 80
Cdd:COG1224   1 MSEIR--EIEKVKEFERISAHSHIRGLGLDENGKAKFVADGLVGQVEAREAAGIVVKMIKEGKMAGKGILIVGPPGTGKT 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6723428   81 AIAMGIAKSLGQETPFTMIAGSEIFSLEMSKTEALTQAFRKAIGVRIKEETDVIEGEVVTISIDR---PASSGGSVKKTG 157
Cdd:COG1224  79 ALAVAIARELGEDTPFVAISGSEIYSAELKKTEFLMQALRKAIGVRVREKRKVYEGVVKEIKIRYarhPYNPYVKVPREA 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6723428  158 KITMKTTDMESNFDLGWKLIEPLDKEKVQSGDVIVLDRFCGKITKLGRS-FTRSRDFDVmgSKTKFVQCPEGELEKRKEV 236
Cdd:COG1224 159 TITLATKDEEKTLTVGEEIAQQLVELGIRKGDVIWIDAETGRVSKLGRAkGEGAKTYDI--ETKRIVEVPSGPVKKEKEI 236

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6723428  237 LHSVTLHEIDVINSRTQGYLALFTG--DTGEIRSETREQSDTKVAEWREEGKAEIVPGVLFIDEVHMLDIECFSFLNRAL 314
Cdd:COG1224 237 VRTLTLHDLDLYLAAQRAAFSALFGffEEREIPSEVRKQVDELVKKWIEEGKAELVPGVLFIDDAHMLDIEAFSFLTRAM 316

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6723428  315 ENDMSPILVVATNRGMTTIRGTNQISAHGIPIDFLDRLLIITTQPYTQDEIRNILEIRCQEEDVEMNEEAKQLLTLIGCN 394
Cdd:COG1224 317 ESELAPIIILATNRGITKIRGTDIESPHGIPLDLLDRLLIIPTRPYTEDEIREIIKIRAEEEDIELSDDALEELTKIGVE 396

                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|....*
gi 6723428  395 TSLRYAIHLINAAALACLKRKGKVVEIQDIERVYRLFLDTKRSMQYLVEHESEYL 449
Cdd:COG1224 397 RSLRYAVQLLEPAYIIAKRRGRSKVTVEDVEEASKLFADVKESVEYVKEYEELFL 451
TIP49_C pfam17856
TIP49 AAA-lid domain; This family consists of the C-terminal region of several eukaryotic and ...
 368-433 6.76e-27

TIP49 AAA-lid domain; This family consists of the C-terminal region of several eukaryotic and archaeal RuvB-like 1 (Pontin or TIP49a) and RuvB-like 2 (Reptin or TIP49b) proteins. The N-terminal domain contains the pfam00004 domain. In zebrafish, the liebeskummer (lik) mutation, causes development of hyperplastic embryonic hearts. lik encodes Reptin, a component of a DNA-stimulated ATPase complex. Beta-catenin and Pontin, a DNA-stimulated ATPase that is often part of complexes with Reptin, are in the same genetic pathways. The Reptin/Pontin ratio serves to regulate heart growth during development, at least in part via the beta-catenin pathway. TBP-interacting protein 49 (TIP49) was originally identified as a TBP-binding protein, and two related proteins are encoded by individual genes, tip49a and b. Although the function of this gene family has not been elucidated, they are supposed to play a critical role in nuclear events because they interact with various kinds of nuclear factors and have DNA helicase activities.TIP49a has been suggested to act as an autoantigen in some patients with autoimmune diseases.


Pssm-ID: 436097 [Multi-domain]  Cd Length: 66  Bit Score: 102.72  E-value: 6.76e-27
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 6723428    368 ILEIRCQEEDVEMNEEAKQLLTLIGCNTSLRYAIHLINAAALACLKRKGKVVEIQDIERVYRLFLD 433
Cdd:pfam17856   1 ILKIRAQEEGVKIDEEALDLLAKIGTETSLRYAIQLLTPASILAKKRGGKEVEVQDVEEAYELFLD 66
cdc6 PRK00411
ORC1-type DNA replication protein;
354-464 3.28e-06

ORC1-type DNA replication protein;


Pssm-ID: 234751 [Multi-domain]  Cd Length: 394  Bit Score: 49.08  E-value: 3.28e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6723428   354 IITTQPYTQDEIRNILEIRCQE---EDVeMNEEAKQLLTLIGCNTS--LRYAIHLINAAALACLKRKGKVVEIQDIERVY 428
Cdd:PRK00411 201 EIYFPPYTADEIFDILKDRVEEgfyPGV-VDDEVLDLIADLTAREHgdARVAIDLLRRAGLIAEREGSRKVTEEDVRKAY 279

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 6723428   429 R--LFLDTKRSMQYLVEHESEYLFSV---PIKNTQEATAGE 464
Cdd:PRK00411 280 EksEIVHLSEVLRTLPLHEKLLLRAIvrlLKKGGDEVTTGE 320
PRK14964 PRK14964
DNA polymerase III subunits gamma and tau; Provisional
 293-409 1.42e-05

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237870 [Multi-domain]  Cd Length: 491  Bit Score: 47.47  E-value: 1.42e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6723428   293 VLFIDEVHMLDIECFSFLNRALENDMSPI-LVVATnrgmTTIRgtnqisahGIPIDFLDRLLIITTQPYTQDEIRNILEI 371
Cdd:PRK14964 119 VYIIDEVHMLSNSAFNALLKTLEEPAPHVkFILAT----TEVK--------KIPVTIISRCQRFDLQKIPTDKLVEHLVD 186

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 6723428   372 RCQEEDVEMNEEAkqlLTLIGCNT--SLRYAIHLINAAAL 409
Cdd:PRK14964 187 IAKKENIEHDEES---LKLIAENSsgSMRNALFLLEQAAI 223
RecA-like_protease cd19481
proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of ...
 57-122 3.79e-04

proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410889 [Multi-domain]  Cd Length: 158  Bit Score: 41.11  E-value: 3.79e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6723428   57 ELIRDGKISGRAILIAGQPGTGKIAIAMGIAKSLGqeTPFTMIAGSEIFSLEMSKTEA-LTQAFRKA 122
Cdd:cd19481  17 RLRRYGLGLPKGILLYGPPGTGKTLLAKALAGELG--LPLIVVKLSSLLSKYVGESEKnLRKIFERA 81
 
Name Accession Description Interval E-value
TIP49 pfam06068
TIP49 P-loop domain; This family consists of the C-terminal region of several eukaryotic and ...
 17-363 0e+00

TIP49 P-loop domain; This family consists of the C-terminal region of several eukaryotic and archaeal RuvB-like 1 (Pontin or TIP49a) and RuvB-like 2 (Reptin or TIP49b) proteins. The N-terminal domain contains the pfam00004 domain. In zebrafish, the liebeskummer (lik) mutation, causes development of hyperplastic embryonic hearts. lik encodes Reptin, a component of a DNA-stimulated ATPase complex. Beta-catenin and Pontin, a DNA-stimulated ATPase that is often part of complexes with Reptin, are in the same genetic pathways. The Reptin/Pontin ratio serves to regulate heart growth during development, at least in part via the beta-catenin pathway. TBP-interacting protein 49 (TIP49) was originally identified as a TBP-binding protein, and two related proteins are encoded by individual genes, tip49a and b. Although the function of this gene family has not been elucidated, they are supposed to play a critical role in nuclear events because they interact with various kinds of nuclear factors and have DNA helicase activities.TIP49a has been suggested to act as an autoantigen in some patients with autoimmune diseases.


Pssm-ID: 399217 [Multi-domain]  Cd Length: 347  Bit Score: 607.00  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6723428     17 RIGAHSHIRGLGLDSVLEPRAVSEGMVGQIKARKAAGVTLELIRDGKISGRAILIAGQPGTGKIAIAMGIAKSLGQETPF 96
Cdd:pfam06068   1 RISAHSHIRGLGLDEDGEARYVSGGLVGQEKAREAAGVIVEMIKEGKIAGRAVLIAGPPGTGKTALAIAISKELGEDTPF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6723428     97 TMIAGSEIFSLEMSKTEALTQAFRKAIGVRIKEETDVIEGEVVTISI---DRPASsGGSVKKTGKITMKTTDMESNFDLG 173
Cdd:pfam06068  81 TSISGSEVYSLEMKKTEALTQAFRKAIGVRIKEEKEVYEGEVVELEIeeaENPLS-GGKTIKGGKITLKTTKMEKTLKLG 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6723428    174 WKLIEPLDKEKVQSGDVIVLDRFCGKITKLGRSFTRSRDFDVmgSKTKFVQCPEGELEKRKEVLHSVTLHEIDVINSRTQ 253
Cdd:pfam06068 160 PKIYEQLQKEKVSAGDVIYIDKNTGRVKKLGRSFARATDFDL--EATEFVPCPKGEVHKRKEVVQTVTLHDIDVANARPQ 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6723428    254 GYLALFTGDTGEIRSETREQSDTKVAEWREEGKAEIVPGVLFIDEVHMLDIECFSFLNRALENDMSPILVVATNRGMTTI 333
Cdd:pfam06068 238 GILSLFSPKKGEITSELREEINKKVNKWIEEGKAEIVPGVLFIDEVHMLDIECFSFLNRALESDLAPIVILATNRGICTI 317

                         330       340       350
                  ....*....|....*....|....*....|
gi 6723428    334 RGTNQISAHGIPIDFLDRLLIITTQPYTQD 363
Cdd:pfam06068 318 RGTDIISPHGIPLDLLDRLLIITTEPYTRE 347
TIP49 COG1224
DNA helicase TIP49, TBP-interacting protein [Transcription];
1-449 1.92e-174

DNA helicase TIP49, TBP-interacting protein [Transcription];


Pssm-ID: 440837 [Multi-domain]  Cd Length: 452  Bit Score: 497.19  E-value: 1.92e-174
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6723428    1 MAELRlsETRDLTRIERIGAHSHIRGLGLDSVLEPRAVSEGMVGQIKARKAAGVTLELIRDGKISGRAILIAGQPGTGKI 80
Cdd:COG1224   1 MSEIR--EIEKVKEFERISAHSHIRGLGLDENGKAKFVADGLVGQVEAREAAGIVVKMIKEGKMAGKGILIVGPPGTGKT 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6723428   81 AIAMGIAKSLGQETPFTMIAGSEIFSLEMSKTEALTQAFRKAIGVRIKEETDVIEGEVVTISIDR---PASSGGSVKKTG 157
Cdd:COG1224  79 ALAVAIARELGEDTPFVAISGSEIYSAELKKTEFLMQALRKAIGVRVREKRKVYEGVVKEIKIRYarhPYNPYVKVPREA 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6723428  158 KITMKTTDMESNFDLGWKLIEPLDKEKVQSGDVIVLDRFCGKITKLGRS-FTRSRDFDVmgSKTKFVQCPEGELEKRKEV 236
Cdd:COG1224 159 TITLATKDEEKTLTVGEEIAQQLVELGIRKGDVIWIDAETGRVSKLGRAkGEGAKTYDI--ETKRIVEVPSGPVKKEKEI 236

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6723428  237 LHSVTLHEIDVINSRTQGYLALFTG--DTGEIRSETREQSDTKVAEWREEGKAEIVPGVLFIDEVHMLDIECFSFLNRAL 314
Cdd:COG1224 237 VRTLTLHDLDLYLAAQRAAFSALFGffEEREIPSEVRKQVDELVKKWIEEGKAELVPGVLFIDDAHMLDIEAFSFLTRAM 316

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6723428  315 ENDMSPILVVATNRGMTTIRGTNQISAHGIPIDFLDRLLIITTQPYTQDEIRNILEIRCQEEDVEMNEEAKQLLTLIGCN 394
Cdd:COG1224 317 ESELAPIIILATNRGITKIRGTDIESPHGIPLDLLDRLLIIPTRPYTEDEIREIIKIRAEEEDIELSDDALEELTKIGVE 396

                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|....*
gi 6723428  395 TSLRYAIHLINAAALACLKRKGKVVEIQDIERVYRLFLDTKRSMQYLVEHESEYL 449
Cdd:COG1224 397 RSLRYAVQLLEPAYIIAKRRGRSKVTVEDVEEASKLFADVKESVEYVKEYEELFL 451
TIP49_C pfam17856
TIP49 AAA-lid domain; This family consists of the C-terminal region of several eukaryotic and ...
 368-433 6.76e-27

TIP49 AAA-lid domain; This family consists of the C-terminal region of several eukaryotic and archaeal RuvB-like 1 (Pontin or TIP49a) and RuvB-like 2 (Reptin or TIP49b) proteins. The N-terminal domain contains the pfam00004 domain. In zebrafish, the liebeskummer (lik) mutation, causes development of hyperplastic embryonic hearts. lik encodes Reptin, a component of a DNA-stimulated ATPase complex. Beta-catenin and Pontin, a DNA-stimulated ATPase that is often part of complexes with Reptin, are in the same genetic pathways. The Reptin/Pontin ratio serves to regulate heart growth during development, at least in part via the beta-catenin pathway. TBP-interacting protein 49 (TIP49) was originally identified as a TBP-binding protein, and two related proteins are encoded by individual genes, tip49a and b. Although the function of this gene family has not been elucidated, they are supposed to play a critical role in nuclear events because they interact with various kinds of nuclear factors and have DNA helicase activities.TIP49a has been suggested to act as an autoantigen in some patients with autoimmune diseases.


Pssm-ID: 436097 [Multi-domain]  Cd Length: 66  Bit Score: 102.72  E-value: 6.76e-27
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 6723428    368 ILEIRCQEEDVEMNEEAKQLLTLIGCNTSLRYAIHLINAAALACLKRKGKVVEIQDIERVYRLFLD 433
Cdd:pfam17856   1 ILKIRAQEEGVKIDEEALDLLAKIGTETSLRYAIQLLTPASILAKKRGGKEVEVQDVEEAYELFLD 66
cdc6 PRK00411
ORC1-type DNA replication protein;
354-464 3.28e-06

ORC1-type DNA replication protein;


Pssm-ID: 234751 [Multi-domain]  Cd Length: 394  Bit Score: 49.08  E-value: 3.28e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6723428   354 IITTQPYTQDEIRNILEIRCQE---EDVeMNEEAKQLLTLIGCNTS--LRYAIHLINAAALACLKRKGKVVEIQDIERVY 428
Cdd:PRK00411 201 EIYFPPYTADEIFDILKDRVEEgfyPGV-VDDEVLDLIADLTAREHgdARVAIDLLRRAGLIAEREGSRKVTEEDVRKAY 279

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 6723428   429 R--LFLDTKRSMQYLVEHESEYLFSV---PIKNTQEATAGE 464
Cdd:PRK00411 280 EksEIVHLSEVLRTLPLHEKLLLRAIvrlLKKGGDEVTTGE 320
PRK14964 PRK14964
DNA polymerase III subunits gamma and tau; Provisional
 293-409 1.42e-05

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237870 [Multi-domain]  Cd Length: 491  Bit Score: 47.47  E-value: 1.42e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6723428   293 VLFIDEVHMLDIECFSFLNRALENDMSPI-LVVATnrgmTTIRgtnqisahGIPIDFLDRLLIITTQPYTQDEIRNILEI 371
Cdd:PRK14964 119 VYIIDEVHMLSNSAFNALLKTLEEPAPHVkFILAT----TEVK--------KIPVTIISRCQRFDLQKIPTDKLVEHLVD 186

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 6723428   372 RCQEEDVEMNEEAkqlLTLIGCNT--SLRYAIHLINAAAL 409
Cdd:PRK14964 187 IAKKENIEHDEES---LKLIAENSsgSMRNALFLLEQAAI 223
SpoVK COG0464
AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle ...
 286-426 7.49e-05

AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 440232 [Multi-domain]  Cd Length: 397  Bit Score: 44.90  E-value: 7.49e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6723428  286 KAE-IVPGVLFIDEVHML-----------DIECFSFLNRALENDMSPILVVATnrgmttirgTNQISAhgIPIDFLDRL- 352
Cdd:COG0464 245 KARgLAPCVLFIDEADALagkrgevgdgvGRRVVNTLLTEMEELRSDVVVIAA---------TNRPDL--LDPALLRRFd 313

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 6723428  353 LIITTQPYTQDEIRNILEIRCQE----EDVEMNEEAKQLLTLIGcntslRYAIHLINAAALACLKRKGKVVEIQDIER 426
Cdd:COG0464 314 EIIFFPLPDAEERLEIFRIHLRKrpldEDVDLEELAEATEGLSG-----ADIRNVVRRAALQALRLGREPVTTEDLLE 386
PRK07773 PRK07773
replicative DNA helicase; Validated
 65-113 7.99e-05

replicative DNA helicase; Validated


Pssm-ID: 236093 [Multi-domain]  Cd Length: 886  Bit Score: 45.13  E-value: 7.99e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 6723428    65 SGRAILIAGQPGTGKIAIAMGIAKSLGqetpFTMIAGSEIFSLEMSKTE 113
Cdd:PRK07773 216 PGQLIIVAARPSMGKTTFGLDFARNCA----IRHRLAVAIFSLEMSKEQ 260
PRK14957 PRK14957
DNA polymerase III subunits gamma and tau; Provisional
 293-430 8.63e-05

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184921 [Multi-domain]  Cd Length: 546  Bit Score: 45.07  E-value: 8.63e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6723428   293 VLFIDEVHMLDIECFSFLNRALENDMSPI-LVVATNrgmttirgtnqiSAHGIPIDFLDRLLIITTQPYTQDEIRNILEI 371
Cdd:PRK14957 122 VYLIDEVHMLSKQSFNALLKTLEEPPEYVkFILATT------------DYHKIPVTILSRCIQLHLKHISQADIKDQLKI 189

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6723428   372 RCQEEDVEMNEEAKQLLTLiGCNTSLRYAIHLINAAALAC---LKRK--GKVVEIQDIERVYRL 430
Cdd:PRK14957 190 ILAKENINSDEQSLEYIAY-HAKGSLRDALSLLDQAISFCggeLKQAqiKQMLGIIDSEEVYSI 252
DnaB_C pfam03796
DnaB-like helicase C terminal domain; The hexameric helicase DnaB unwinds the DNA duplex at ...
 69-113 1.02e-04

DnaB-like helicase C terminal domain; The hexameric helicase DnaB unwinds the DNA duplex at the Escherichia coli chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a change in the quaternary structure of the protein involving dimerization of the N-terminal domain has been observed and may occur during the enzymatic cycle. This C-terminal domain contains an ATP-binding site and is therefore probably the site of ATP hydrolysis.


Pssm-ID: 427509 [Multi-domain]  Cd Length: 254  Bit Score: 43.94  E-value: 1.02e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 6723428     69 ILIAGQPGTGKIAIAMGIAKSLGQETPftmiAGSEIFSLEMSKTE 113
Cdd:pfam03796  22 IIIAARPSMGKTAFALNIARNAAVKHK----KPVAIFSLEMSAEQ 62
RecA-like_protease cd19481
proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of ...
 57-122 3.79e-04

proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410889 [Multi-domain]  Cd Length: 158  Bit Score: 41.11  E-value: 3.79e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6723428   57 ELIRDGKISGRAILIAGQPGTGKIAIAMGIAKSLGqeTPFTMIAGSEIFSLEMSKTEA-LTQAFRKA 122
Cdd:cd19481  17 RLRRYGLGLPKGILLYGPPGTGKTLLAKALAGELG--LPLIVVKLSSLLSKYVGESEKnLRKIFERA 81
DnaB_C cd00984
C-terminal domain of DnaB helicase; DnaB helicase C-terminal domain. The hexameric helicase ...
 69-113 6.09e-04

C-terminal domain of DnaB helicase; DnaB helicase C-terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a change in the quaternary structure of the protein involving dimerization of the N-terminal domain has been observed and may occur during the enzymatic cycle. This C-terminal domain contains an ATP-binding site and is therefore probably the site of ATP hydrolysis.


Pssm-ID: 410864 [Multi-domain]  Cd Length: 256  Bit Score: 41.34  E-value: 6.09e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 6723428   69 ILIAGQPGTGKIAIAMGIAKSLGQETPFTMIagseIFSLEMSKTE 113
Cdd:cd00984  22 IIIAARPSMGKTAFALNIAENIALDEGLPVL----FFSLEMSAEQ 62
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 69-122 1.25e-03

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 38.73  E-value: 1.25e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 6723428     69 ILIAGQPGTGKIAIAMGIAKSLGqeTPFTMIAGSEIFSLEMSKTEA-LTQAFRKA 122
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAKELG--APFIEISGSELVSKYVGESEKrLRELFEAA 53
PRK14953 PRK14953
DNA polymerase III subunits gamma and tau; Provisional
 293-388 4.52e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237867 [Multi-domain]  Cd Length: 486  Bit Score: 39.42  E-value: 4.52e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6723428   293 VLFIDEVHMLDIECFSFLNRALENDM-SPILVVATNRgmttirgtnqisAHGIPIDFLDRLLIITTQPYTQDEIRNILEI 371
Cdd:PRK14953 122 VYIIDEAHMLTKEAFNALLKTLEEPPpRTIFILCTTE------------YDKIPPTILSRCQRFIFSKPTKEQIKEYLKR 189

                         90
                 ....*....|....*..
gi 6723428   372 RCQEEDVEMNEEAKQLL 388
Cdd:PRK14953 190 ICNEEKIEYEEKALDLL 206
PRK14961 PRK14961
DNA polymerase III subunits gamma and tau; Provisional
 293-407 5.61e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184925 [Multi-domain]  Cd Length: 363  Bit Score: 39.02  E-value: 5.61e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6723428   293 VLFIDEVHMLDIECFSFLNRALENDMSPI-LVVATNrgmttirgtnqiSAHGIPIDFLDRLLIITTQPYTQDEIRNILEI 371
Cdd:PRK14961 122 VYLIDEVHMLSRHSFNALLKTLEEPPQHIkFILATT------------DVEKIPKTILSRCLQFKLKIISEEKIFNFLKY 189

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 6723428   372 RCQEEDVEMNEEAKQLLTLiGCNTSLRYAIHLINAA 407
Cdd:PRK14961 190 ILIKESIDTDEYALKLIAY-HAHGSMRDALNLLEHA 224
DnaB COG0305
Replicative DNA helicase [Replication, recombination and repair];
69-113 6.18e-03

Replicative DNA helicase [Replication, recombination and repair];


Pssm-ID: 440074 [Multi-domain]  Cd Length: 429  Bit Score: 38.90  E-value: 6.18e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 6723428   69 ILIAGQPGTGKIAIAMGIAKSLGQETPFTMIagseIFSLEMSKTE 113
Cdd:COG0305 194 IILAARPSMGKTAFALNIARNAAIKEGKPVA----IFSLEMSAEQ 234
PRK05636 PRK05636
replicative DNA helicase; Provisional
 56-127 8.33e-03

replicative DNA helicase; Provisional


Pssm-ID: 180177 [Multi-domain]  Cd Length: 505  Bit Score: 38.67  E-value: 8.33e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6723428    56 LELIRDGKISGRAILIAGQPGTGKIAIAMGIAKSLGQETPFTmiagSEIFSLEMSKTEALTQAFRKAIGVRI 127
Cdd:PRK05636 255 LDDLTNGLRGGQMIIVAARPGVGKSTLALDFMRSASIKHNKA----SVIFSLEMSKSEIVMRLLSAEAEVRL 322
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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