NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|10798535|emb|CAC12808|]
View 

p13 [Takifugu rubripes]

Protein Classification

ankyrin repeat domain-containing protein( domain architecture ID 11429852)

ankyrin repeat domain-containing protein; ANK proteins mediate specific protein-protein interactions without necessarily recognizing specific primary sequences which allows for one ankyrin repeat domain to recognize and bind to a variety of intracellular substrates and may be involved in a wide array of functions

Gene Ontology:  GO:0005515
PubMed:  17176038
SCOP:  4000366

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
19-121 7.03e-23

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 90.01  E-value: 7.03e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10798535  19 VRSLLGAGAQVNGVNCFGRTALQV-MMMGSTRVAQILLDHGADPNVADGTtGATPLHDAARSGFLDTVRLLVRFTADPNA 97
Cdd:COG0666 103 VKLLLEAGADVNARDKDGETPLHLaAYNGNLEIVKLLLEAGADVNAQDND-GNTPLHLAAANGNLEIVKLLLEAGADVNA 181

                        90       100
                ....*....|....*....|....
gi 10798535  98 RDQADRRPVDLARDECHTDVVAFL 121
Cdd:COG0666 182 RDNDGETPLHLAAENGHLEIVKLL 205
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
19-121 7.03e-23

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 90.01  E-value: 7.03e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10798535  19 VRSLLGAGAQVNGVNCFGRTALQV-MMMGSTRVAQILLDHGADPNVADGTtGATPLHDAARSGFLDTVRLLVRFTADPNA 97
Cdd:COG0666 103 VKLLLEAGADVNARDKDGETPLHLaAYNGNLEIVKLLLEAGADVNAQDND-GNTPLHLAAANGNLEIVKLLLEAGADVNA 181

                        90       100
                ....*....|....*....|....
gi 10798535  98 RDQADRRPVDLARDECHTDVVAFL 121
Cdd:COG0666 182 RDNDGETPLHLAAENGHLEIVKLL 205
Ank_2 pfam12796
Ankyrin repeats (3 copies);
19-99 1.16e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 66.68  E-value: 1.16e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10798535    19 VRSLLGAGAQVNGVNCFGRTALQV-MMMGSTRVAQILLDHgadPNVADGTTGATPLHDAARSGFLDTVRLLVRFTADPNA 97
Cdd:pfam12796  13 VKLLLENGADANLQDKNGRTALHLaAKNGHLEIVKLLLEH---ADVNLKDNGRTALHYAARSGHLEIVKLLLEKGADINV 89


                  ..
gi 10798535    98 RD 99
Cdd:pfam12796  90 KD 91
PHA03095 PHA03095
ankyrin-like protein; Provisional
 19-107 5.54e-12

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 61.19  E-value: 5.54e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10798535   19 VRSLLGAGAQVNGVNCFGRTALQVMMMGST--RVAQILLDHGADPNVADGTtGATPLHDAARSGFLD--TVRLLVRFTAD 94
Cdd:PHA03095  66 VRLLLEAGADVNAPERCGFTPLHLYLYNATtlDVIKLLIKAGADVNAKDKV-GRTPLHVYLSGFNINpkVIRLLLRKGAD 144

                         90
                 ....*....|...
gi 10798535   95 PNARDQADRRPVD 107
Cdd:PHA03095 145 VNALDLYGMTPLA 157
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 69-97 1.20e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.80  E-value: 1.20e-04
                           10        20
                   ....*....|....*....|....*....
gi 10798535     69 GATPLHDAARSGFLDTVRLLVRFTADPNA 97
Cdd:smart00248   2 GRTPLHLAAENGNLEVVKLLLDKGADINA 30
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
19-121 7.03e-23

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 90.01  E-value: 7.03e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10798535  19 VRSLLGAGAQVNGVNCFGRTALQV-MMMGSTRVAQILLDHGADPNVADGTtGATPLHDAARSGFLDTVRLLVRFTADPNA 97
Cdd:COG0666 103 VKLLLEAGADVNARDKDGETPLHLaAYNGNLEIVKLLLEAGADVNAQDND-GNTPLHLAAANGNLEIVKLLLEAGADVNA 181

                        90       100
                ....*....|....*....|....
gi 10798535  98 RDQADRRPVDLARDECHTDVVAFL 121
Cdd:COG0666 182 RDNDGETPLHLAAENGHLEIVKLL 205
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
19-122 4.16e-22

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 88.09  E-value: 4.16e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10798535  19 VRSLLGAGAQVNGVNCFGRTALQV-MMMGSTRVAQILLDHGADPNVADGTtGATPLHDAARSGFLDTVRLLVRFTADPNA 97
Cdd:COG0666 136 VKLLLEAGADVNAQDNDGNTPLHLaAANGNLEIVKLLLEAGADVNARDND-GETPLHLAAENGHLEIVKLLLEAGADVNA 214

                        90       100
                ....*....|....*....|....*
gi 10798535  98 RDQADRRPVDLARDECHTDVVAFLE 122
Cdd:COG0666 215 KDNDGKTALDLAAENGNLEIVKLLL 239
Ank_2 pfam12796
Ankyrin repeats (3 copies);
19-99 1.16e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 66.68  E-value: 1.16e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10798535    19 VRSLLGAGAQVNGVNCFGRTALQV-MMMGSTRVAQILLDHgadPNVADGTTGATPLHDAARSGFLDTVRLLVRFTADPNA 97
Cdd:pfam12796  13 VKLLLENGADANLQDKNGRTALHLaAKNGHLEIVKLLLEH---ADVNLKDNGRTALHYAARSGHLEIVKLLLEKGADINV 89


                  ..
gi 10798535    98 RD 99
Cdd:pfam12796  90 KD 91
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
19-121 2.70e-15

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 69.98  E-value: 2.70e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10798535  19 VRSLLGAGAQVNGVNCFGRTALQV-MMMGSTRVAQILLDHGADPNVADgTTGATPLHDAARSGFLDTVRLLVRFTADPNA 97
Cdd:COG0666 169 VKLLLEAGADVNARDNDGETPLHLaAENGHLEIVKLLLEAGADVNAKD-NDGKTALDLAAENGNLEIVKLLLEAGADLNA 247

                        90       100
                ....*....|....*....|....
gi 10798535  98 RDQADRRPVDLARDECHTDVVAFL 121
Cdd:COG0666 248 KDKDGLTALLLAAAAGAALIVKLL 271
PHA03095 PHA03095
ankyrin-like protein; Provisional
 19-107 5.54e-12

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 61.19  E-value: 5.54e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10798535   19 VRSLLGAGAQVNGVNCFGRTALQVMMMGST--RVAQILLDHGADPNVADGTtGATPLHDAARSGFLD--TVRLLVRFTAD 94
Cdd:PHA03095  66 VRLLLEAGADVNAPERCGFTPLHLYLYNATtlDVIKLLIKAGADVNAKDKV-GRTPLHVYLSGFNINpkVIRLLLRKGAD 144

                         90
                 ....*....|...
gi 10798535   95 PNARDQADRRPVD 107
Cdd:PHA03095 145 VNALDLYGMTPLA 157
PHA03095 PHA03095
ankyrin-like protein; Provisional
 19-121 1.12e-11

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 60.04  E-value: 1.12e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10798535   19 VRSLLGAGAQVNGVNCFGRTALQVMMMGS----TRVAQILLDHGADPNVADgTTGATPLHDAARSGF-LDTVRLLVRFTA 93
Cdd:PHA03095  30 VRRLLAAGADVNFRGEYGKTPLHLYLHYSsekvKDIVRLLLEAGADVNAPE-RCGFTPLHLYLYNATtLDVIKLLIKAGA 108

                         90       100       110
                 ....*....|....*....|....*....|
gi 10798535   94 DPNARDQADRRP--VDLARDECHTDVVAFL 121
Cdd:PHA03095 109 DVNAKDKVGRTPlhVYLSGFNINPKVIRLL 138
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 41-123 4.42e-11

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 58.37  E-value: 4.42e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10798535   41 QVMMMGSTRVAQILLDHGADPNVADgTTGATPLHDAARSGFLDTVRLLVRFTADPNARDQADRRPVDLARDECHTDVVAF 120
Cdd:PTZ00322  88 QLAASGDAVGARILLTGGADPNCRD-YDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQL 166


                 ...
gi 10798535  121 LES 123
Cdd:PTZ00322 167 LSR 169
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
22-121 8.87e-10

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 54.57  E-value: 8.87e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10798535  22 LLGAGAQVNGVNCFGRTALQVMMMGSTRVAQILLDHGADPNVADGTTGATPLHDAARSGFLDTVRLLVRFTADPNARDQA 101
Cdd:COG0666  40 LLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKD 119

                        90       100
                ....*....|....*....|
gi 10798535 102 DRRPVDLARDECHTDVVAFL 121
Cdd:COG0666 120 GETPLHLAAYNGNLEIVKLL 139
PHA03095 PHA03095
ankyrin-like protein; Provisional
 19-123 1.02e-09

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 54.65  E-value: 1.02e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10798535   19 VRSLLGAGAQVNGVNCFGRTALQVMMMGSTRVAQI---LLDHGADPNVADgTTGATPLHDAARSGFLDTVRLLVRFTADP 95
Cdd:PHA03095 205 VRELIRAGCDPAATDMLGNTPLHSMATGSSCKRSLvlpLLIAGISINARN-RYGQTPLHYAAVFNNPRACRRLIALGADI 283

                         90       100
                 ....*....|....*....|....*....
gi 10798535   96 NARDQADRRPVDLA-RDECHTDVVAFLES 123
Cdd:PHA03095 284 NAVSSDGNTPLSLMvRNNNGRAVRAALAK 312
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 6-101 4.54e-09

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 52.98  E-value: 4.54e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10798535    6 ELTAAAAKGDAAQVRSLLGAGAQVNGVNCFGRTALQVM-MMGSTRVAQILLDHGADPNVADgTTGATPLHDAARSGFLDT 84
Cdd:PTZ00322  85 ELCQLAASGDAVGARILLTGGADPNCRDYDGRTPLHIAcANGHVQVVRVLLEFGADPTLLD-KDGKTPLELAEENGFREV 163

                         90       100
                 ....*....|....*....|..
gi 10798535   85 VRLLVR-----FTADPNARDQA 101
Cdd:PTZ00322 164 VQLLSRhsqchFELGANAKPDS 185
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 19-121 8.02e-09

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 51.97  E-value: 8.02e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10798535   19 VRSLLGAGAQVNGVNCFGRTALQVMMMGSTR---VAQILLDHGADPNVAD--------GTT-------GATPLHDAARSG 80
Cdd:PHA03100 124 VEYLLDNGANVNIKNSDGENLLHLYLESNKIdlkILKLLIDKGVDINAKNrvnyllsyGVPinikdvyGFTPLHYAVYNN 203

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 10798535   81 FLDTVRLLVRFTADPNARDQADRRPVDLARDECHTDVVAFL 121
Cdd:PHA03100 204 NPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLL 244
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 19-109 5.34e-08

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 49.49  E-value: 5.34e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10798535   19 VRSLLGAGAQVNGVNCFGRTALQ--VMMMGSTRVAQILLDHGADPNVADGTTGATPLHDAARSGflDTVRLLVRFTADPN 96
Cdd:PHA02878 217 VHILLENGASTDARDKCGNTPLHisVGYCKDYDILKLLLEHGVDVNAKSYILGLTALHSSIKSE--RKLKLLLEYGADIN 294

                         90
                 ....*....|...
gi 10798535   97 ARDQADRRPVDLA 109
Cdd:PHA02878 295 SLNSYKLTPLSSA 307
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 19-109 2.65e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 47.75  E-value: 2.65e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10798535   19 VRSLLGAGAQVNGVNCFGRTALQVMMMG--STRVAQILLDHGADPNVADgTTGATPLHDAAR-SGFLDTVRLLVRFTADP 95
Cdd:PHA02876 290 VPKLLERGADVNAKNIKGETPLYLMAKNgyDTENIRTLIMLGADVNAAD-RLYITPLHQASTlDRNKDIVITLLELGANV 368

                         90
                 ....*....|....
gi 10798535   96 NARDQADRRPVDLA 109
Cdd:PHA02876 369 NARDYCDKTPIHYA 382
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 48-121 3.69e-07

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 47.18  E-value: 3.69e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 10798535   48 TRVAQILLDHGADPNVADGTTGATPLHDAARSGFLDTVRLLVRFTADPNARDQADRRPVDLARDECHTDVVAFL 121
Cdd:PHA02878 147 AEITKLLLSYGADINMKDRHKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHIL 220
Ank_4 pfam13637
Ankyrin repeats (many copies);
36-89 3.82e-06

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 41.11  E-value: 3.82e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 10798535    36 GRTALQV-MMMGSTRVAQILLDHGADPNVADGTtGATPLHDAARSGFLDTVRLLV 89
Cdd:pfam13637   1 ELTALHAaAASGHLELLRLLLEKGADINAVDGN-GETALHFAASNGNVEVLKLLL 54
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 19-113 8.21e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 43.33  E-value: 8.21e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10798535   19 VRSLLGAGAQVNGVN-CFGRTALQVMMMG-STRVAQILLDHGADPNVADgTTGATPLHDAARSGFLDTVRLLVRFTADPN 96
Cdd:PHA02878 150 TKLLLSYGADINMKDrHKGNTALHYATENkDQRLTELLLSYGANVNIPD-KTNNSPLHHAVKHYNKPIVHILLENGASTD 228

                         90
                 ....*....|....*..
gi 10798535   97 ARDQADRRPVDLARDEC 113
Cdd:PHA02878 229 ARDKCGNTPLHISVGYC 245
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 19-106 1.05e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 43.03  E-value: 1.05e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10798535   19 VRSLLGAGAQVNGVNCFGRTALQ-VMMMGSTRVAQILLDHGADPNVADgTTGATPLHDAARSGFLDTVRLLVRFTADPNA 97
Cdd:PHA02874 107 IKTILDCGIDVNIKDAELKTFLHyAIKKGDLESIKMLFEYGADVNIED-DNGCYPIHIAIKHNFFDIIKLLLEKGAYANV 185


                 ....*....
gi 10798535   98 RDQADRRPV 106
Cdd:PHA02874 186 KDNNGESPL 194
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 69-99 3.60e-05

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 38.42  E-value: 3.60e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 10798535    69 GATPLHDAA-RSGFLDTVRLLVRFTADPNARD 99
Cdd:pfam00023   2 GNTPLHLAAgRRGNLEIVKLLLSKGADVNARD 33
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 69-97 1.20e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.80  E-value: 1.20e-04
                           10        20
                   ....*....|....*....|....*....
gi 10798535     69 GATPLHDAARSGFLDTVRLLVRFTADPNA 97
Cdd:smart00248   2 GRTPLHLAAENGNLEVVKLLLDKGADINA 30
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
19-104 1.39e-04

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 39.94  E-value: 1.39e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10798535  19 VRSLLGAGAQVNGVNCFGRTALQV-MMMGSTRVAQILLDHGADPNVADGtTGATPLHDAARSGFLDTVRLLVRFTADPNA 97
Cdd:COG0666 202 VKLLLEAGADVNAKDNDGKTALDLaAENGNLEIVKLLLEAGADLNAKDK-DGLTALLLAAAAGAALIVKLLLLALLLLAA 280


                ....*..
gi 10798535  98 RDQADRR 104
Cdd:COG0666 281 ALLDLLT 287
Ank_4 pfam13637
Ankyrin repeats (many copies);
71-121 1.70e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 36.87  E-value: 1.70e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 10798535    71 TPLHDAARSGFLDTVRLLVRFTADPNARDQADRRPVDLARDECHTDVVAFL 121
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLL 53
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 22-96 3.31e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 38.82  E-value: 3.31e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 10798535   22 LLGAGAQVNGVNCFGRTALQVMM-MGSTRVAQILLDHGADPNVADGTTGATPLHDAARSGFLDTVRLLVRFTADPN 96
Cdd:PHA02875 154 LIDHKACLDIEDCCGCTPLIIAMaKGDIAICKMLLDSGANIDYFGKNGCVAALCYAIENNKIDIVRLFIKRGADCN 229
Ank_5 pfam13857
Ankyrin repeats (many copies);
54-109 3.64e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 36.17  E-value: 3.64e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 10798535    54 LLDHGADPNVADGTTGATPLHDAARSGFLDTVRLLVRFTADPNARDQADRRPVDLA 109
Cdd:pfam13857   1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
Ank_2 pfam12796
Ankyrin repeats (3 copies);
73-121 5.74e-04

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 36.25  E-value: 5.74e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 10798535    73 LHDAARSGFLDTVRLLVRFTADPNARDQADRRPVDLARDECHTDVVAFL 121
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLL 49
PHA03095 PHA03095
ankyrin-like protein; Provisional
 19-123 5.88e-04

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 38.08  E-value: 5.88e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10798535   19 VRSLLGAGAQVNGVNCFGRTALQVmMMGSTRVA----QILLDHGADPNVADgTTGATPLHDAARSGFLDT--VRLLVRFT 92
Cdd:PHA03095 135 IRLLLRKGADVNALDLYGMTPLAV-LLKSRNANvellRLLIDAGADVYAVD-DRFRSLLHHHLQSFKPRAriVRELIRAG 212

                         90       100       110
                 ....*....|....*....|....*....|....
gi 10798535   93 ADPNARDQADRRPVDLARDEC---HTDVVAFLES 123
Cdd:PHA03095 213 CDPAATDMLGNTPLHSMATGSsckRSLVLPLLIA 246
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 36-65 8.62e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 34.57  E-value: 8.62e-04
                          10        20        30
                  ....*....|....*....|....*....|..
gi 10798535    36 GRTALQ--VMMMGSTRVAQILLDHGADPNVAD 65
Cdd:pfam00023   2 GNTPLHlaAGRRGNLEIVKLLLSKGADVNARD 33
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 19-121 9.27e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 37.64  E-value: 9.27e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10798535   19 VRSLLGAGAQVNGVNC-FGRTALQVMMMGSTRVAQILLDHGAD------PNVADGTTGA----------------TPLHD 75
Cdd:PHA02874  51 VELFIKHGADINHINTkIPHPLLTAIKIGAHDIIKLLIDNGVDtsilpiPCIEKDMIKTildcgidvnikdaelkTFLHY 130

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 10798535   76 AARSGFLDTVRLLVRFTADPNARDQADRRPVDLARDECHTDVVAFL 121
Cdd:PHA02874 131 AIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLL 176
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 49-96 1.11e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 37.35  E-value: 1.11e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 10798535   49 RVAQILLDHGADPNVADgTTGATPLHDAARSGFLDTVRLLVRFTADPN 96
Cdd:PHA02876 159 LIAEMLLEGGADVNAKD-IYCITPIHYAAERGNAKMVNLLLSYGADVN 205
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 69-97 1.54e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 33.77  E-value: 1.54e-03
                          10        20
                  ....*....|....*....|....*....
gi 10798535    69 GATPLHDAARSGFLDTVRLLVRFTADPNA 97
Cdd:pfam13606   2 GNTPLHLAARNGRLEIVKLLLENGADINA 30
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 22-99 1.71e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 36.97  E-value: 1.71e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 10798535   22 LLGAGAQVNGVNCFGRTALQ-VMMMGSTRVAQILLDHGADPNVAdGTTGATPLHDAARSGFLDTVRLLVRFTADPNARD 99
Cdd:PHA02876 164 LLEGGADVNAKDIYCITPIHyAAERGNAKMVNLLLSYGADVNII-ALDDLSVLECAVDSKNIDTIKAIIDNRSNINKND 241
PHA02946 PHA02946
ankyin-like protein; Provisional
 49-106 6.57e-03

ankyin-like protein; Provisional


Pssm-ID: 165256 [Multi-domain]  Cd Length: 446  Bit Score: 35.03  E-value: 6.57e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 10798535   49 RVAQILLDHGADPNVADgTTGATPLHDAARSGFLDTVRLLVRFTADPNARDQADRRPV 106
Cdd:PHA02946  53 RFVEELLHRGYSPNETD-DDGNYPLHIASKINNNRIVAMLLTHGADPNACDKQHKTPL 109
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 46-109 7.68e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 34.97  E-value: 7.68e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 10798535   46 GSTRVAQILLDHGADPNVADGTTGATPLHDAARSGFLDTVRLLVRFTADPNARDQADRRPVDLA 109
Cdd:PHA02875  79 GDVKAVEELLDLGKFADDVFYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLA 142
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH