NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1789991060|emb|CAC14424|]
View 

PB1 domain-containing protein [Caenorhabditis elegans]

Protein Classification

PB1 domain-containing protein( domain architecture ID 10456513)

PB1 domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PB1 pfam00564
PB1 domain;
137-206 1.01e-09

PB1 domain;


:

Pssm-ID: 395447  Cd Length: 84  Bit Score: 54.61  E-value: 1.01e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789991060 137 STVLKARHVDFVHKTsIHHTNDLTLIDLVLNVQWRLALPsDANFVLKYKNKQGDLVTLVVDSDLLMVLHT 206
Cdd:pfam00564   1 TVRLKLRYGGGIRRF-LSVSRGISFEELRALVEQRFGLD-DVDFKLKYPDEDGDLVSLTSDEDLEEALEE 68
 
Name Accession Description Interval E-value
PB1 pfam00564
PB1 domain;
137-206 1.01e-09

PB1 domain;


Pssm-ID: 395447  Cd Length: 84  Bit Score: 54.61  E-value: 1.01e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789991060 137 STVLKARHVDFVHKTsIHHTNDLTLIDLVLNVQWRLALPsDANFVLKYKNKQGDLVTLVVDSDLLMVLHT 206
Cdd:pfam00564   1 TVRLKLRYGGGIRRF-LSVSRGISFEELRALVEQRFGLD-DVDFKLKYPDEDGDLVSLTSDEDLEEALEE 68
PB1 smart00666
PB1 domain; Phox and Bem1p domain, present in many eukaryotic cytoplasmic signalling proteins. ...
 137-206 4.16e-09

PB1 domain; Phox and Bem1p domain, present in many eukaryotic cytoplasmic signalling proteins. The domain adopts a beta-grasp fold, similar to that found in ubiquitin and Ras-binding domains. A motif, variously termed OPR, PC and AID, represents the most conserved region of the majority of PB1 domains, and is necessary for PB1 domain function. This function is the formation of PB1 domain heterodimers, although not all PB1 domain pairs associate.


Pssm-ID: 214770  Cd Length: 81  Bit Score: 52.59  E-value: 4.16e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789991060  137 STVLKARHVDFVHKTSIHHtnDLTLIDLVLNVQWRLALpSDANFVLKYKNKQGDLVTLVVDSDLLMVLHT 206
Cdd:smart00666   1 TVDVKLRYGGETRRLSVPR--DISFEDLRSKVAKRFGL-DNQSFTLKYQDEDGDLVSLTSDEDLEEAIEE 67
PB1_TFG cd06401
The PB1 domain found in TFG protein, an oncogenic gene product and fusion partner to nerve ...
 139-207 2.07e-04

The PB1 domain found in TFG protein, an oncogenic gene product and fusion partner to nerve growth factor tyrosine kinase receptor TrkA and to the tyrosine kinase ALK. The PB1 domain is a modular domain mediating specific protein-protein interaction in many critical cell processes, such as osteoclastogenesis, angiogenesis, early cardiovascular development and cell polarity. A canonical PB1-PB1 interaction, which involves heterodimerization of two PB1 domains, is required for the formation of macromolecular signaling complexes ensuring specificity and fidelity during cellular signaling. The interaction between two PB1 domain depends on the type of PB1. There are three types of PB1 domains: type I which contains an OPCA motif, acidic aminoacid cluster, type II which contains a basic cluster, and type I/II which contains both an OPCA motif and a basic cluster. The PB1 domains of TFG represent a type I/II PB1 domain. The physiological function of TFG remains unknown.


Pssm-ID: 99722  Cd Length: 81  Bit Score: 39.42  E-value: 2.07e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1789991060 139 VLKARHVDFVHKTSIHHtNDLTLIDLVLNVQ--WRLALPSDANFVLKYKNKQGDLVTLVVDSDLLMVLHTS 207
Cdd:cd06401     2 ILKAQLGDDIRRIPIHN-EDITYDELLLMMQrvFRGKLGSSDDVLIKYKDEDGDLITIFDSSDLSFAIQCS 71
 
Name Accession Description Interval E-value
PB1 pfam00564
PB1 domain;
137-206 1.01e-09

PB1 domain;


Pssm-ID: 395447  Cd Length: 84  Bit Score: 54.61  E-value: 1.01e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789991060 137 STVLKARHVDFVHKTsIHHTNDLTLIDLVLNVQWRLALPsDANFVLKYKNKQGDLVTLVVDSDLLMVLHT 206
Cdd:pfam00564   1 TVRLKLRYGGGIRRF-LSVSRGISFEELRALVEQRFGLD-DVDFKLKYPDEDGDLVSLTSDEDLEEALEE 68
PB1 smart00666
PB1 domain; Phox and Bem1p domain, present in many eukaryotic cytoplasmic signalling proteins. ...
 137-206 4.16e-09

PB1 domain; Phox and Bem1p domain, present in many eukaryotic cytoplasmic signalling proteins. The domain adopts a beta-grasp fold, similar to that found in ubiquitin and Ras-binding domains. A motif, variously termed OPR, PC and AID, represents the most conserved region of the majority of PB1 domains, and is necessary for PB1 domain function. This function is the formation of PB1 domain heterodimers, although not all PB1 domain pairs associate.


Pssm-ID: 214770  Cd Length: 81  Bit Score: 52.59  E-value: 4.16e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789991060  137 STVLKARHVDFVHKTSIHHtnDLTLIDLVLNVQWRLALpSDANFVLKYKNKQGDLVTLVVDSDLLMVLHT 206
Cdd:smart00666   1 TVDVKLRYGGETRRLSVPR--DISFEDLRSKVAKRFGL-DNQSFTLKYQDEDGDLVSLTSDEDLEEAIEE 67
PB1_TFG cd06401
The PB1 domain found in TFG protein, an oncogenic gene product and fusion partner to nerve ...
 139-207 2.07e-04

The PB1 domain found in TFG protein, an oncogenic gene product and fusion partner to nerve growth factor tyrosine kinase receptor TrkA and to the tyrosine kinase ALK. The PB1 domain is a modular domain mediating specific protein-protein interaction in many critical cell processes, such as osteoclastogenesis, angiogenesis, early cardiovascular development and cell polarity. A canonical PB1-PB1 interaction, which involves heterodimerization of two PB1 domains, is required for the formation of macromolecular signaling complexes ensuring specificity and fidelity during cellular signaling. The interaction between two PB1 domain depends on the type of PB1. There are three types of PB1 domains: type I which contains an OPCA motif, acidic aminoacid cluster, type II which contains a basic cluster, and type I/II which contains both an OPCA motif and a basic cluster. The PB1 domains of TFG represent a type I/II PB1 domain. The physiological function of TFG remains unknown.


Pssm-ID: 99722  Cd Length: 81  Bit Score: 39.42  E-value: 2.07e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1789991060 139 VLKARHVDFVHKTSIHHtNDLTLIDLVLNVQ--WRLALPSDANFVLKYKNKQGDLVTLVVDSDLLMVLHTS 207
Cdd:cd06401     2 ILKAQLGDDIRRIPIHN-EDITYDELLLMMQrvFRGKLGSSDDVLIKYKDEDGDLITIFDSSDLSFAIQCS 71
PB1 cd05992
The PB1 domain is a modular domain mediating specific protein-protein interactions which play ...
 138-217 1.91e-03

The PB1 domain is a modular domain mediating specific protein-protein interactions which play a role in many critical cell processes, such as osteoclastogenesis, angiogenesis, early cardiovascular development, and cell polarity. A canonical PB1-PB1 interaction, which involves heterodimerization of two PB1 domain, is required for the formation of macromolecular signaling complexes ensuring specificity and fidelity during cellular signaling. The interaction between two PB1 domain depends on the type of PB1. There are three types of PB1 domains: type I which contains an OPCA motif, acidic aminoacid cluster, type II which contains a basic cluster, and type I/II which contains both an OPCA motif and a basic cluster. Interactions of PB1 domains with other protein domains have been described as a noncanonical PB1-interactions. The PB1 domain module is conserved in amoebas, fungi, animals, and plants.


Pssm-ID: 99716 [Multi-domain]  Cd Length: 81  Bit Score: 36.87  E-value: 1.91e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789991060 138 TVLKARHVDFVHKTSIHHtNDLTLIDLVLNVQWRLALPSDaNFVLKYKNKQGDLVTLVVDSDLLMVLHTSGATFDVTVVV 217
Cdd:cd05992     1 VRVKVKYGGEIRRFVVVS-RSISFEDLRSKIAEKFGLDAV-SFKLKYPDEDGDLVTISSDEDLEEAIEEARRSGSKKLRL 78
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH