|
Name |
Accession |
Description |
Interval |
E-value |
| GT33_ALG1-like |
cd03816 |
chitobiosyldiphosphodolichol beta-mannosyltransferase and similar proteins; This family is ... |
1-380 |
0e+00 |
|
chitobiosyldiphosphodolichol beta-mannosyltransferase and similar proteins; This family is most closely related to the GT33 family of glycosyltransferases. The yeast gene ALG1 has been shown to function as a mannosyltransferase that catalyzes the formation of dolichol pyrophosphate (Dol-PP)-GlcNAc2Man from GDP-Man and Dol-PP-Glc-NAc2, and participates in the formation of the lipid-linked precursor oligosaccharide for N-glycosylation. In humans ALG1 has been associated with the congenital disorders of glycosylation (CDG) designated as subtype CDG-Ik.
Pssm-ID: 340843 [Multi-domain] Cd Length: 411 Bit Score: 607.35 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14035914 1 MQYHALSLAMHGFSVTLLGFCNSKPHDELLQNNRIQIVGLTELQSLAVGPRVFQYGVKVVLQAMYLLWKLMWREPGAYIF 80
Cdd:cd03816 20 MQYHALSLARHGWRVDLIGYLESPPHDELLSHPNITIHALPPPPTKNKLPFLLFAPLKVLLQALSLLWLLYELRPADYIL 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14035914 81 LQNPPGLPSIAVCWFVGCLCGSKLVIDWHNYGYSIMGLVHGPNHPLVLLAKWYEKFFGRLSHLNLCVTNAMREDLA--DN 158
Cdd:cd03816 100 VQNPPSIPTLAIAWLYCRLRRTKLIIDWHNFGYTILALKLGENHPLVRLAKWYEKTFGRMADAHLCVTKAMQRDLQqfEN 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14035914 159 WHIRAVTVYDKPASFFKETPLDLQHRLFMKLgsmhspfrarsepedpvtersaFTERDAGSGLVTRLRERPALLVSSTSW 238
Cdd:cd03816 180 WNIRATVLYDRPPSHFRPIPLEEKHELFLEL----------------------ALFRELAEGAVSYKEGRPALLVSSTSW 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14035914 239 TEDEDFSILLAALEKFEQLTLDGH-NLPSLVCVITGKGPLREYYSRLIHQKHFQHIQVCTPWLEAEDYPLLLGSADLGVC 317
Cdd:cd03816 238 TPDEDFSILLDALKAYESSAATEPaLLPSLLCIITGKGPLKEMYLELIKELKLKKVTIRTPWLSAEDYPRLLASADLGVC 317
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 14035914 318 LHTSSSGLDLPMKVVDMFGCCLPVCAVNFKCLHELVKHEENGLVFEDSEELAAQLQMLFSNFP 380
Cdd:cd03816 318 LHTSSSGLDLPMKVVDMFGCGLPVCAMDFKCIGELVKHGVNGLVFGDSEELAEQLIDLLSDFD 380
|
|
| PLN02275 |
PLN02275 |
transferase, transferring glycosyl groups |
1-376 |
1.77e-143 |
|
transferase, transferring glycosyl groups
Pssm-ID: 215155 [Multi-domain] Cd Length: 371 Bit Score: 412.14 E-value: 1.77e-143
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14035914 1 MQYHALSLAMH-GFSVTLLGFCNSKPHDELLQNNRIQI---VGLTELQSLAVGPRVFQYGVKVVLQAMYLLWKLMWREPG 76
Cdd:PLN02275 21 MQYHALSLARQaSFQVDVVAYGGSEPIPALLNHPSIHIhlmVQPRLLQRLPRVLYALALLLKVAIQFLMLLWFLCVKIPR 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14035914 77 AYIFL-QNPPGLPSIAVCWFVGCLCGSKLVIDWHNYGYSIMGLVHGPNHPLVLLAKWYEKFFGRLSHLNLCVTNAMREDL 155
Cdd:PLN02275 101 PDVFLvQNPPSVPTLAVVKLACWLRRAKFVIDWHNFGYTLLALSLGRSHPLVRLYRWYERHYGKMADGHLCVTKAMQHEL 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14035914 156 ADNWHIRAVTVYDKPASFFKETPLdlqhrlfmklgsmhspfrarsepedpvtersafterdagsglVTRLRE-RPALLVS 234
Cdd:PLN02275 181 DQNWGIRATVLYDQPPEFFRPASL------------------------------------------EIRLRPnRPALVVS 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14035914 235 STSWTEDEDFSILLAALEKFEQL---TLDGHN--------LPSLVCVITGKGPLREYYSRLIHQKHFQHIQVCTPWLEAE 303
Cdd:PLN02275 219 STSWTPDEDFGILLEAAVMYDRRvaaRLNESDsasgkqslYPRLLFIITGKGPQKAMYEEKISRLNLRHVAFRTMWLEAE 298
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 14035914 304 DYPLLLGSADLGVCLHTSSSGLDLPMKVVDMFGCCLPVCAVNFKCLHELVKHEENGLVFEDSEELAAQLQMLF 376
Cdd:PLN02275 299 DYPLLLGSADLGVSLHTSSSGLDLPMKVVDMFGCGLPVCAVSYSCIGELVKDGKNGLLFSSSSELADQLLELL 371
|
|
| RfaB |
COG0438 |
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ... |
282-384 |
8.75e-09 |
|
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440207 [Multi-domain] Cd Length: 123 Bit Score: 53.07 E-value: 8.75e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14035914 282 SRLIHQKHFQHIqvctpwLEAedyplLLGSADlgVCLHTSSSGlDLPMKVVDMFGCCLPVCAVNFKCLHELVKHEENGLV 361
Cdd:COG0438 2 GRLVPRKGLDLL------LEA-----LLAAAD--VFVLPSRSE-GFGLVLLEAMAAGLPVIATDVGGLPEVIEDGETGLL 67
|
90 100
....*....|....*....|....*
gi 14035914 362 FE--DSEELAAQLQMLFSNfPDLRA 384
Cdd:COG0438 68 VPpgDPEALAEAILRLLED-PELRR 91
|
|
| Glycos_transf_1 |
pfam00534 |
Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease ... |
247-384 |
1.41e-08 |
|
Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease (Paroxysmal Nocturnal haemoglobinuria). Members of this family transfer activated sugars to a variety of substrates, including glycogen, Fructose-6-phosphate and lipopolysaccharides. Members of this family transfer UDP, ADP, GDP or CMP linked sugars. The eukaryotic glycogen synthases may be distant members of this family.
Pssm-ID: 425737 [Multi-domain] Cd Length: 158 Bit Score: 53.43 E-value: 1.41e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14035914 247 LLAALEKFEQltldghNLPSLVCVITGKGPLREYYSRLIHQKHFQHIQVCTPWLEAEDYPLLLGSADLGVCLHTSSSgld 326
Cdd:pfam00534 20 LIKAFALLKE------KNPNLKLVIAGDGEEEKRLKKLAEKLGLGDNVIFLGFVSDEDLPELLKIADVFVLPSRYEG--- 90
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 14035914 327 LPMKVVDMFGCCLPVCAVNFKCLHELVKHEENGLVFE--DSEELAAQLQMLFSNfPDLRA 384
Cdd:pfam00534 91 FGIVLLEAMACGLPVIASDVGGPPEVVKDGETGFLVKpnNAEALAEAIDKLLED-EELRE 149
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| GT33_ALG1-like |
cd03816 |
chitobiosyldiphosphodolichol beta-mannosyltransferase and similar proteins; This family is ... |
1-380 |
0e+00 |
|
chitobiosyldiphosphodolichol beta-mannosyltransferase and similar proteins; This family is most closely related to the GT33 family of glycosyltransferases. The yeast gene ALG1 has been shown to function as a mannosyltransferase that catalyzes the formation of dolichol pyrophosphate (Dol-PP)-GlcNAc2Man from GDP-Man and Dol-PP-Glc-NAc2, and participates in the formation of the lipid-linked precursor oligosaccharide for N-glycosylation. In humans ALG1 has been associated with the congenital disorders of glycosylation (CDG) designated as subtype CDG-Ik.
Pssm-ID: 340843 [Multi-domain] Cd Length: 411 Bit Score: 607.35 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14035914 1 MQYHALSLAMHGFSVTLLGFCNSKPHDELLQNNRIQIVGLTELQSLAVGPRVFQYGVKVVLQAMYLLWKLMWREPGAYIF 80
Cdd:cd03816 20 MQYHALSLARHGWRVDLIGYLESPPHDELLSHPNITIHALPPPPTKNKLPFLLFAPLKVLLQALSLLWLLYELRPADYIL 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14035914 81 LQNPPGLPSIAVCWFVGCLCGSKLVIDWHNYGYSIMGLVHGPNHPLVLLAKWYEKFFGRLSHLNLCVTNAMREDLA--DN 158
Cdd:cd03816 100 VQNPPSIPTLAIAWLYCRLRRTKLIIDWHNFGYTILALKLGENHPLVRLAKWYEKTFGRMADAHLCVTKAMQRDLQqfEN 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14035914 159 WHIRAVTVYDKPASFFKETPLDLQHRLFMKLgsmhspfrarsepedpvtersaFTERDAGSGLVTRLRERPALLVSSTSW 238
Cdd:cd03816 180 WNIRATVLYDRPPSHFRPIPLEEKHELFLEL----------------------ALFRELAEGAVSYKEGRPALLVSSTSW 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14035914 239 TEDEDFSILLAALEKFEQLTLDGH-NLPSLVCVITGKGPLREYYSRLIHQKHFQHIQVCTPWLEAEDYPLLLGSADLGVC 317
Cdd:cd03816 238 TPDEDFSILLDALKAYESSAATEPaLLPSLLCIITGKGPLKEMYLELIKELKLKKVTIRTPWLSAEDYPRLLASADLGVC 317
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 14035914 318 LHTSSSGLDLPMKVVDMFGCCLPVCAVNFKCLHELVKHEENGLVFEDSEELAAQLQMLFSNFP 380
Cdd:cd03816 318 LHTSSSGLDLPMKVVDMFGCGLPVCAMDFKCIGELVKHGVNGLVFGDSEELAEQLIDLLSDFD 380
|
|
| PLN02275 |
PLN02275 |
transferase, transferring glycosyl groups |
1-376 |
1.77e-143 |
|
transferase, transferring glycosyl groups
Pssm-ID: 215155 [Multi-domain] Cd Length: 371 Bit Score: 412.14 E-value: 1.77e-143
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14035914 1 MQYHALSLAMH-GFSVTLLGFCNSKPHDELLQNNRIQI---VGLTELQSLAVGPRVFQYGVKVVLQAMYLLWKLMWREPG 76
Cdd:PLN02275 21 MQYHALSLARQaSFQVDVVAYGGSEPIPALLNHPSIHIhlmVQPRLLQRLPRVLYALALLLKVAIQFLMLLWFLCVKIPR 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14035914 77 AYIFL-QNPPGLPSIAVCWFVGCLCGSKLVIDWHNYGYSIMGLVHGPNHPLVLLAKWYEKFFGRLSHLNLCVTNAMREDL 155
Cdd:PLN02275 101 PDVFLvQNPPSVPTLAVVKLACWLRRAKFVIDWHNFGYTLLALSLGRSHPLVRLYRWYERHYGKMADGHLCVTKAMQHEL 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14035914 156 ADNWHIRAVTVYDKPASFFKETPLdlqhrlfmklgsmhspfrarsepedpvtersafterdagsglVTRLRE-RPALLVS 234
Cdd:PLN02275 181 DQNWGIRATVLYDQPPEFFRPASL------------------------------------------EIRLRPnRPALVVS 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14035914 235 STSWTEDEDFSILLAALEKFEQL---TLDGHN--------LPSLVCVITGKGPLREYYSRLIHQKHFQHIQVCTPWLEAE 303
Cdd:PLN02275 219 STSWTPDEDFGILLEAAVMYDRRvaaRLNESDsasgkqslYPRLLFIITGKGPQKAMYEEKISRLNLRHVAFRTMWLEAE 298
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 14035914 304 DYPLLLGSADLGVCLHTSSSGLDLPMKVVDMFGCCLPVCAVNFKCLHELVKHEENGLVFEDSEELAAQLQMLF 376
Cdd:PLN02275 299 DYPLLLGSADLGVSLHTSSSGLDLPMKVVDMFGCGLPVCAVSYSCIGELVKDGKNGLLFSSSSELADQLLELL 371
|
|
| GT4_PimA-like |
cd03801 |
phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 ... |
5-384 |
1.58e-09 |
|
phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.
Pssm-ID: 340831 [Multi-domain] Cd Length: 366 Bit Score: 59.09 E-value: 1.58e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14035914 5 ALSLAMHGFSVTLLGFCNSKPHDELLQNNRIQIvgltelqsLAVGPRVFQYGVKVVLQamylLWKLMWREPGAYIFLQNP 84
Cdd:cd03801 24 ARALAARGHDVTVLTPADPGEPPEELEDGVIVP--------LLPSLAALLRARRLLRE----LRPLLRLRKFDVVHAHGL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14035914 85 PGLPSIAVCWFvgcLCGSKLVIDWHNYGYSIMGLVHGPNHPLvlLAKWyeKFFGRLSHLNLCVTNAMREDLADNWHI--- 161
Cdd:cd03801 92 LAALLAALLAL---LLGAPLVVTLHGAEPGRLLLLLAAERRL--LARA--EALLRRADAVIAVSEALRDELRALGGIppe 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14035914 162 RAVTVYdkpasffkeTPLDLQHrlfmklgsmhSPFRARSEPEDPVTERSAFTerdagsglVTRLRERPALLVsstswted 241
Cdd:cd03801 165 KIVVIP---------NGVDLER----------FSPPLRRKLGIPPDRPVLLF--------VGRLSPRKGVDL-------- 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14035914 242 edfsiLLAALEKFEQLtldghnLPSLVCVITGKGPlrEYYSRLIHQKHFQHIQV-CTPWLEAEDYPLLLGSADLGVCLHT 320
Cdd:cd03801 210 -----LLEALAKLLRR------GPDVRLVIVGGDG--PLRAELEELELGLGDRVrFLGFVPDEELPALYAAADVFVLPSR 276
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 14035914 321 SSSgldLPMKVVDMFGCCLPVCAVNFKCLHELVKHEENGLVFE--DSEELAAQLQMLFSNfPDLRA 384
Cdd:cd03801 277 YEG---FGLVVLEAMAAGLPVVATDVGGLPEVVEDGEGGLVVPpdDVEALADALLRLLAD-PELRA 338
|
|
| RfaB |
COG0438 |
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ... |
282-384 |
8.75e-09 |
|
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440207 [Multi-domain] Cd Length: 123 Bit Score: 53.07 E-value: 8.75e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14035914 282 SRLIHQKHFQHIqvctpwLEAedyplLLGSADlgVCLHTSSSGlDLPMKVVDMFGCCLPVCAVNFKCLHELVKHEENGLV 361
Cdd:COG0438 2 GRLVPRKGLDLL------LEA-----LLAAAD--VFVLPSRSE-GFGLVLLEAMAAGLPVIATDVGGLPEVIEDGETGLL 67
|
90 100
....*....|....*....|....*
gi 14035914 362 FE--DSEELAAQLQMLFSNfPDLRA 384
Cdd:COG0438 68 VPpgDPEALAEAILRLLED-PELRR 91
|
|
| GT4_WbuB-like |
cd03794 |
Escherichia coli WbuB and similar proteins; This family is most closely related to the GT1 ... |
5-384 |
1.34e-08 |
|
Escherichia coli WbuB and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. WbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase.
Pssm-ID: 340825 [Multi-domain] Cd Length: 391 Bit Score: 56.20 E-value: 1.34e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14035914 5 ALSLAMHGFSVTLLGFCNSKPHDELLQNN-------RIQIVGLTELQSLAVGPRVFQYgvkVVLQAMYLLWKLMWREPGA 77
Cdd:cd03794 24 AKELVRRGHEVTVLTPSPNYPLGRIFAGAtetkdgiRVIRVKLGPIKKNGLIRRLLNY---LSFALAALLKLLVREERPD 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14035914 78 YIFLQNPPGLPSIAVCWFVGcLCGSKLVID----WHNygySIMGLVHGPNHPLVLLAKWYEKFFGRLSHLNLCVTNAMRE 153
Cdd:cd03794 101 VIIAYSPPITLGLAALLLKK-LRGAPFILDvrdlWPE---SLIALGVLKKGSLLKLLKKLERKLYRLADAIIVLSPGLKE 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14035914 154 dladnwHIRAVTVYDKPASFFKEtpldlqhrlfmklGSMHSPFRarsePEDPVTERSAFTERDagsglvtrlrerPALLV 233
Cdd:cd03794 177 ------YLLRKGVPKEKIIVIPN-------------WADLEEFK----PPPKDELRKKLGLDD------------KFVVV 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14035914 234 SSTSWTEDEDFSILLAALEKFEQLtldghnlPSLVCVITGKGPLREYYSRLIHQKHfqhIQVCT--PWLEAEDYPLLLGS 311
Cdd:cd03794 222 YAGNIGKAQGLETLLEAAERLKRR-------PDIRFLFVGDGDEKERLKELAKARG---LDNVTflGRVPKEEVPELLSA 291
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 14035914 312 ADLG-VCLHTS-SSGLDLPMKVVDMFGCCLPVCAVNFKCLHELVKHEENGLVFE--DSEELAAQLQMLFSNfPDLRA 384
Cdd:cd03794 292 ADVGlVPLKDNpANRGSSPSKLFEYMAAGKPILASDDGGSDLAVEINGCGLVVEpgDPEALADAILELLDD-PELRR 367
|
|
| Glycos_transf_1 |
pfam00534 |
Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease ... |
247-384 |
1.41e-08 |
|
Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease (Paroxysmal Nocturnal haemoglobinuria). Members of this family transfer activated sugars to a variety of substrates, including glycogen, Fructose-6-phosphate and lipopolysaccharides. Members of this family transfer UDP, ADP, GDP or CMP linked sugars. The eukaryotic glycogen synthases may be distant members of this family.
Pssm-ID: 425737 [Multi-domain] Cd Length: 158 Bit Score: 53.43 E-value: 1.41e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14035914 247 LLAALEKFEQltldghNLPSLVCVITGKGPLREYYSRLIHQKHFQHIQVCTPWLEAEDYPLLLGSADLGVCLHTSSSgld 326
Cdd:pfam00534 20 LIKAFALLKE------KNPNLKLVIAGDGEEEKRLKKLAEKLGLGDNVIFLGFVSDEDLPELLKIADVFVLPSRYEG--- 90
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 14035914 327 LPMKVVDMFGCCLPVCAVNFKCLHELVKHEENGLVFE--DSEELAAQLQMLFSNfPDLRA 384
Cdd:pfam00534 91 FGIVLLEAMACGLPVIASDVGGPPEVVKDGETGFLVKpnNAEALAEAIDKLLED-EELRE 149
|
|
| Glycosyltransferase_GTB-type |
cd01635 |
glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases ... |
204-362 |
1.24e-07 |
|
glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. The structures of the formed glycoconjugates are extremely diverse, reflecting a wide range of biological functions. The members of this family share a common GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.
Pssm-ID: 340816 [Multi-domain] Cd Length: 235 Bit Score: 52.02 E-value: 1.24e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14035914 204 DPVTERSAFTERDAGSGLVTRLRERPALLVSStsWTEDEDFSILLAALEKFeqltldGHNLPSLVCVITGKGPLREYYSR 283
Cdd:cd01635 87 GPDSLESTRSELLALARLLVSLPLADKVSVGR--LVPEKGIDLLLEALALL------KARLPDLVLVLVGGGGEREEEEA 158
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14035914 284 LI-HQKHFQHIQVCTPWLEAEDYPLLLGSADLGVCLHTSSSgldLPMKVVDMFGCCLPVCAVNFKCLHELVKHEENGLVF 362
Cdd:cd01635 159 LAaALGLLERVVIIGGLVDDEVLELLLAAADVFVLPSRSEG---FGLVLLEAMAAGKPVIATDVGGIPEFVVDGENGLLV 235
|
|
| GT4_GT28_WabH-like |
cd03811 |
family 4 and family 28 glycosyltransferases similar to Klebsiella WabH; This family is most ... |
12-383 |
3.65e-06 |
|
family 4 and family 28 glycosyltransferases similar to Klebsiella WabH; This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core.
Pssm-ID: 340839 [Multi-domain] Cd Length: 351 Bit Score: 48.51 E-value: 3.65e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14035914 12 GFSVTLLGFCNSKPHDELLqNNRIQIVGLTELQSLAVGPRVFqygvKVVLQAMYLLWKLM------WREPGAYIF-LQNP 84
Cdd:cd03811 29 GYDVTLVLLRDEGDLDKQL-NGDVKLIRLLIRVLKLIKLGLL----KAILKLKRILKRAKpdvvisFLGFATYIVaKLAA 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14035914 85 PGLPSIAVCwfvgclcgsklvidwHNYgYSImglvhgpNHPLVLLAKWYEKFFGRLSHLnLCVTNAMREDLADNWHI--- 161
Cdd:cd03811 104 ARSKVIAWI---------------HSS-LSK-------LYYLKKKLLLKLKLYKKADKI-VCVSKGIKEDLIRLGPSppe 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14035914 162 RAVTVYDkpasffketPLDLQHrlfmklgsmhspFRARSEPEDPVTERSAFTerdagsgLVT--RLrerpallvsstswT 239
Cdd:cd03811 160 KIEVIYN---------PIDIDR------------IRALAKEPILNEPEDGPV-------ILAvgRL-------------D 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14035914 240 EDEDFSILLAAlekFEQLTLDGHNLPslvCVITGKGPLREYYSRLIHQkhfqhiqvctpwLEAEDYPLLLG--------- 310
Cdd:cd03811 199 PQKGHDLLIEA---FAKLRKKYPDVK---LVILGDGPLREELEKLAKE------------LGLAERVIFLGfqsnpypyl 260
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 14035914 311 -SADLGVclHTSSS-GLdlPMKVVDMFGCCLPVCAVNFKCLHELVKHEENGLVFE--DSEELAAQLQMLFSNFPDLR 383
Cdd:cd03811 261 kKADLFV--LSSRYeGF--PNVLLEAMALGTPVVSTDCPGPREILDDGENGLLVPdgDAAALAGILAALLQKKLDAA 333
|
|
| GT4_CapM-like |
cd03808 |
capsular polysaccharide biosynthesis glycosyltransferase CapM and similar proteins; This ... |
61-385 |
5.00e-05 |
|
capsular polysaccharide biosynthesis glycosyltransferase CapM and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. CapM in Staphylococcus aureus is required for the synthesis of type 1 capsular polysaccharides.
Pssm-ID: 340837 [Multi-domain] Cd Length: 358 Bit Score: 44.89 E-value: 5.00e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14035914 61 LQAMYLLWKLMWREPGAYIFLQNP-PG-LPSIAvcwfvGCLCGSKLVIdwhnygYSI--MGLVHGPNHPLVLLAKWYEKF 136
Cdd:cd03808 67 LKALFKLYKLLKKEKPDIVHCHTPkPGiLGRLA-----ARLAGVPKVI------YTVhgLGFVFTEGKLLRLLYLLLEKL 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14035914 137 FGRLSHLNLCVTNAMREDLADNWHIRAVTVYDKPASffketPLDLQHRlfmklgsmhsPFRARSEPEDPVTersaFterd 216
Cdd:cd03808 136 ALLFTDKVIFVNEDDRDLAIKKGIIKKKKTVLIPGS-----GVDLDRF----------QYSPESLPSEKVV----F---- 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14035914 217 agsGLVTRLRErpallvsstswteDEDFSILLAALEKFEQltldghNLPSLVCVITGKGPLREYYSRLIHQKHFQHIQVC 296
Cdd:cd03808 193 ---LFVARLLK-------------DKGIDELIEAAKILKK------KGPNVRFLLVGDGELENPSEILIEKLGLEGRIEF 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14035914 297 TPWLEaeDYPLLLGSADLgVCLHTSSSGLdlPMKVV------------DMFGCClpvcavnfkclhELVKHEENGLVFE- 363
Cdd:cd03808 251 LGFRS--DVPELLAESDV-FVLPSYREGL--PRSLLeamaagrpvittDVPGCR------------ELVIDGVNGFLVPp 313
|
330 340
....*....|....*....|...
gi 14035914 364 -DSEELAAQLQMLFSNfPDLRAS 385
Cdd:cd03808 314 gDVEALADAIEKLIED-PELRKE 335
|
|
| GT4_UGDG-like |
cd03817 |
UDP-Glc:1,2-diacylglycerol 3-a-glucosyltransferase and similar proteins; This family is most ... |
244-370 |
3.20e-04 |
|
UDP-Glc:1,2-diacylglycerol 3-a-glucosyltransferase and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (EC 2.4.1.337, UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1,2-diacylglycerol forming 3-D-glucosyl-1,2-diacylglycerol.
Pssm-ID: 340844 [Multi-domain] Cd Length: 372 Bit Score: 42.27 E-value: 3.20e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14035914 244 FSILLAALEKFeqltldgHNLPSLVCVITGKGPLREYYSRLIHQKHFQHIQVCTPWLEAEDYPLLLGSADLGVclHTSSS 323
Cdd:cd03817 216 IDFLLRAFAEL-------KKEPNIKLVIVGDGPEREELKELARELGLADKVIFTGFVPREELPEYYKAADLFV--FASTT 286
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 14035914 324 GLdLPMKVVDMFGCCLPVCAVNFKCLHELVKHEENGLVFEDSEELAA 370
Cdd:cd03817 287 ET-QGLVYLEAMAAGLPVVAAKDPAASELVEDGENGFLFEPNDETLA 332
|
|
| GT4_AmsD-like |
cd03820 |
amylovoran biosynthesis glycosyltransferase AmsD and similar proteins; This family is most ... |
271-383 |
7.47e-04 |
|
amylovoran biosynthesis glycosyltransferase AmsD and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be responsible for the formation of galactose alpha-1,6 linkages in amylovoran.
Pssm-ID: 340847 [Multi-domain] Cd Length: 351 Bit Score: 41.07 E-value: 7.47e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14035914 271 ITGKGPLREYYSRLIHQKHFQH-IQVCTPWLEAEDYpllLGSADLGVClhtSSS--GLdlPMKVVDMFGCCLPVcaVNFK 347
Cdd:cd03820 217 IYGDGPEREELEKLIDKLGLEDrVKLLGPTKNIAEE---YANSSIFVL---SSRyeGF--PMVLLEAMAYGLPI--ISFD 286
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 14035914 348 CLH---ELVKHEENGLVFE--DSEELAAQLQMLFSNfPDLR 383
Cdd:cd03820 287 CPTgpsEIIEDGENGLLVPngDVDALAEALLRLMED-EELR 326
|
|
| |
