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Conserved domains on  [gi|21732361|emb|CAD38558|]
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hypothetical protein, partial [Homo sapiens]

Protein Classification

Kelch repeat-containing protein( domain architecture ID 18656853)

Kelch repeat-containing protein, member of a superfamily of proteins with diverse functions; similar to Mus musculus Rab9 effector protein with kelch motifs, which is a Rab9 effector required for endosome to trans-Golgi network (TGN) transport

CATH:  2.120.10.80
Gene Ontology:  GO:0005515
PubMed:  10603472|31442578|24959344
SCOP:  3000448

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
36-290 1.06e-61

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 198.07  E-value: 1.06e-61
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21732361  36 PRKSTVGAL-----YAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNG-RRLQFGVAVIDNKLYVVGGRDG----LKTLNT 105
Cdd:COG3055  12 PRSEAAAALldgkvYVAGGLSGGSASNSFEVYDPATNTWSELAPLPGpPRHHAAAVAQDGKLYVFGGFTGanpsSTPLND 91

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21732361 106 VECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTV-GVVALNNK 184
Cdd:COG3055  92 VYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLPTPRDHLaAAVLPDGK 171

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21732361 185 LYAIGGRDGSSclksmeyfdpHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNhcsrlsdcVERYDPKGDSWS 264
Cdd:COG3055 172 ILVIGGRNGSG----------FSNTWTTLAPLPTARAGHAAAVLGGKILVFGGESGFSDE--------VEAYDPATNTWT 233

                       250       260
                ....*....|....*....|....*.
gi 21732361 265 TVAPLSVPRDAVAVCPLGDKLYVVGG 290
Cdd:COG3055 234 ALGELPTPRHGHAAVLTDGKVYVIGG 259
Kelch smart00612
Kelch domain;
284-328 6.86e-11

Kelch domain;


:

Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 56.80  E-value: 6.86e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 21732361    284 KLYVVGGYDGHTYLNTVESYDAQRNEWKEEVPVNIGRAGACVVVV 328
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVI 45
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
36-290 1.06e-61

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 198.07  E-value: 1.06e-61
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21732361  36 PRKSTVGAL-----YAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNG-RRLQFGVAVIDNKLYVVGGRDG----LKTLNT 105
Cdd:COG3055  12 PRSEAAAALldgkvYVAGGLSGGSASNSFEVYDPATNTWSELAPLPGpPRHHAAAVAQDGKLYVFGGFTGanpsSTPLND 91

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21732361 106 VECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTV-GVVALNNK 184
Cdd:COG3055  92 VYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLPTPRDHLaAAVLPDGK 171

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21732361 185 LYAIGGRDGSSclksmeyfdpHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNhcsrlsdcVERYDPKGDSWS 264
Cdd:COG3055 172 ILVIGGRNGSG----------FSNTWTTLAPLPTARAGHAAAVLGGKILVFGGESGFSDE--------VEAYDPATNTWT 233

                       250       260
                ....*....|....*....|....*.
gi 21732361 265 TVAPLSVPRDAVAVCPLGDKLYVVGG 290
Cdd:COG3055 234 ALGELPTPRHGHAAVLTDGKVYVIGG 259
PHA03098 PHA03098
kelch-like protein; Provisional
 82-311 1.23e-53

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 183.82  E-value: 1.23e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21732361   82 FGVAVIDNKLYVVGGRDG-LKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHDGWSYLNTVERWDPEG 160
Cdd:PHA03098 288 FGSVVLNNVIYFIGGMNKnNLSVNSVVSYDTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGIYNSISLNTVESWKPGE 367

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21732361  161 RQWNYVASMSTPRSTVGVVALNNKLYAIGG-RDGSSCLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGhd 239
Cdd:PHA03098 368 SKWREEPPLIFPRYNPCVVNVNNLIYVIGGiSKNDELLKTVECFSLNTNKWSKGSPLPISHYGGCAIYHDGKIYVIGG-- 445

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 21732361  240 apaSNHCSRLS--DCVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGYDGHTYLNTVESYDAQRNEWK 311
Cdd:PHA03098 446 ---ISYIDNIKvyNIVESYNPVTNKWTELSSLNFPRINASLCIFNNKIYVVGGDKYEYYINEIEVYDDKTNTWT 516
Kelch smart00612
Kelch domain;
184-230 1.63e-15

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 69.51  E-value: 1.63e-15
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 21732361    184 KLYAIGGRDGSSCLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNG 230
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 78-123 4.08e-13

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 63.01  E-value: 4.08e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 21732361    78 RRLQFGVAVIDNKLYVVGGRDGLKTLNTVECFNPVGKIWTVMPPMS 123
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
Kelch smart00612
Kelch domain;
284-328 6.86e-11

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 56.80  E-value: 6.86e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 21732361    284 KLYVVGGYDGHTYLNTVESYDAQRNEWKEEVPVNIGRAGACVVVV 328
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVI 45
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 272-312 9.49e-09

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 50.69  E-value: 9.49e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 21732361   272 PRDAVAVCPLGDKLYVVGGYDGHTYLNTVESYDAQRNEWKE 312
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSK 41
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
36-290 1.06e-61

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 198.07  E-value: 1.06e-61
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21732361  36 PRKSTVGAL-----YAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNG-RRLQFGVAVIDNKLYVVGGRDG----LKTLNT 105
Cdd:COG3055  12 PRSEAAAALldgkvYVAGGLSGGSASNSFEVYDPATNTWSELAPLPGpPRHHAAAVAQDGKLYVFGGFTGanpsSTPLND 91

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21732361 106 VECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTV-GVVALNNK 184
Cdd:COG3055  92 VYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLPTPRDHLaAAVLPDGK 171

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21732361 185 LYAIGGRDGSSclksmeyfdpHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNhcsrlsdcVERYDPKGDSWS 264
Cdd:COG3055 172 ILVIGGRNGSG----------FSNTWTTLAPLPTARAGHAAAVLGGKILVFGGESGFSDE--------VEAYDPATNTWT 233

                       250       260
                ....*....|....*....|....*.
gi 21732361 265 TVAPLSVPRDAVAVCPLGDKLYVVGG 290
Cdd:COG3055 234 ALGELPTPRHGHAAVLTDGKVYVIGG 259
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
68-323 1.87e-55

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 181.89  E-value: 1.87e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21732361  68 SWLHIGTMNGRRLQFGVAVIDNKLYVVGGRDGLKTLNTVECFNPVGKIWTVMPPMST-HRHGLGVATLEGPMYAVGG--- 143
Cdd:COG3055   2 TWSSLPDLPTPRSEAAAALLDGKVYVAGGLSGGSASNSFEVYDPATNTWSELAPLPGpPRHHAAAVAQDGKLYVFGGftg 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21732361 144 -HDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSSCLKSMEYFDPHTNKWSLCAPMSKRRGG 222
Cdd:COG3055  82 aNPSSTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLPTPRDH 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21732361 223 VGVAT-YNGFLYVVGGHDAPASNhcsrlsdcverydpkgDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGYDGhtYLNTVE 301
Cdd:COG3055 162 LAAAVlPDGKILVIGGRNGSGFS----------------NTWTTLAPLPTARAGHAAAVLGGKILVFGGESG--FSDEVE 223

                       250       260
                ....*....|....*....|..
gi 21732361 302 SYDAQRNEWKEEVPVNIGRAGA 323
Cdd:COG3055 224 AYDPATNTWTALGELPTPRHGH 245
PHA03098 PHA03098
kelch-like protein; Provisional
 82-311 1.23e-53

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 183.82  E-value: 1.23e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21732361   82 FGVAVIDNKLYVVGGRDG-LKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHDGWSYLNTVERWDPEG 160
Cdd:PHA03098 288 FGSVVLNNVIYFIGGMNKnNLSVNSVVSYDTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGIYNSISLNTVESWKPGE 367

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21732361  161 RQWNYVASMSTPRSTVGVVALNNKLYAIGG-RDGSSCLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGhd 239
Cdd:PHA03098 368 SKWREEPPLIFPRYNPCVVNVNNLIYVIGGiSKNDELLKTVECFSLNTNKWSKGSPLPISHYGGCAIYHDGKIYVIGG-- 445

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 21732361  240 apaSNHCSRLS--DCVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGYDGHTYLNTVESYDAQRNEWK 311
Cdd:PHA03098 446 ---ISYIDNIKvyNIVESYNPVTNKWTELSSLNFPRINASLCIFNNKIYVVGGDKYEYYINEIEVYDDKTNTWT 516
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
42-241 7.55e-41

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 143.76  E-value: 7.55e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21732361  42 GALYAVGGMDAMKG----TTTIEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGGRDGLKTLNTVECFNPVGKIWT 117
Cdd:COG3055  71 GKLYVFGGFTGANPsstpLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWT 150

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21732361 118 VMPPMSTHRHGLGVATL-EGPMYAVGGHDGWSYLNTverwdpegrqWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSSc 196
Cdd:COG3055 151 QLAPLPTPRDHLAAAVLpDGKILVIGGRNGSGFSNT----------WTTLAPLPTARAGHAAAVLGGKILVFGGESGFS- 219

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 21732361 197 lKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAP 241
Cdd:COG3055 220 -DEVEAYDPATNTWTALGELPTPRHGHAAVLTDGKVYVIGGETKP 263
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
162-328 2.33e-37

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 134.90  E-value: 2.33e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21732361 162 QWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSSCLKSMEYFDPHTNKWSLCAPMS-KRRGGVGVATYNGFLYVVGGHDA 240
Cdd:COG3055   2 TWSSLPDLPTPRSEAAAALLDGKVYVAGGLSGGSASNSFEVYDPATNTWSELAPLPgPPRHHAAAVAQDGKLYVFGGFTG 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21732361 241 PASNhcSRLSDCVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGYDGHTYLNTVESYDAQRNEWKEEVPVNIGR 320
Cdd:COG3055  82 ANPS--STPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLPTPR 159


                ....*...
gi 21732361 321 AGACVVVV 328
Cdd:COG3055 160 DHLAAAVL 167
PHA03098 PHA03098
kelch-like protein; Provisional
 124-325 5.36e-32

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 125.27  E-value: 5.36e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21732361  124 THRHGLGVATLEGPMYAVGGHDGWSY-LNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSSCLKSMEY 202
Cdd:PHA03098 283 HYVYCFGSVVLNNVIYFIGGMNKNNLsVNSVVSYDTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGIYNSISLNTVES 362

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21732361  203 FDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDapaSNHcsRLSDCVERYDPKGDSWSTVAPLSVPRDAVAVCPLG 282
Cdd:PHA03098 363 WKPGESKWREEPPLIFPRYNPCVVNVNNLIYVIGGIS---KND--ELLKTVECFSLNTNKWSKGSPLPISHYGGCAIYHD 437

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 21732361  283 DKLYVVGGY---DGHTYLNTVESYDAQRNEWKEEVPVNIGRAGACV 325
Cdd:PHA03098 438 GKIYVIGGIsyiDNIKVYNIVESYNPVTNKWTELSSLNFPRINASL 483
PHA03098 PHA03098
kelch-like protein; Provisional
 44-212 2.65e-24

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 103.31  E-value: 2.65e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21732361   44 LYAVGGMD-AMKGTTTIEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGGRDGLKTLNTVECFNPVGKIWTVMPPM 122
Cdd:PHA03098 297 IYFIGGMNkNNLSVNSVVSYDTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGIYNSISLNTVESWKPGESKWREEPPL 376

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21732361  123 STHRHGLGVATLEGPMYAVGG--------------------------------------HDGWSYL-------------N 151
Cdd:PHA03098 377 IFPRYNPCVVNVNNLIYVIGGiskndellktvecfslntnkwskgsplpishyggcaiyHDGKIYViggisyidnikvyN 456

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 21732361  152 TVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSSCLKSMEYFDPHTNKWSL 212
Cdd:PHA03098 457 IVESYNPVTNKWTELSSLNFPRINASLCIFNNKIYVVGGDKYEYYINEIEVYDDKTNTWTL 517
PHA03098 PHA03098
kelch-like protein; Provisional
 177-327 7.13e-22

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 95.99  E-value: 7.13e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21732361  177 GVVALNNKLYAIGGRDGSS-CLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDapasNHCSrLSDcVER 255
Cdd:PHA03098 289 GSVVLNNVIYFIGGMNKNNlSVNSVVSYDTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGIY----NSIS-LNT-VES 362

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 21732361  256 YDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGG-YDGHTYLNTVESYDAQRNEWKEEVPVNIGRAGACVVV 327
Cdd:PHA03098 363 WKPGESKWREEPPLIFPRYNPCVVNVNNLIYVIGGiSKNDELLKTVECFSLNTNKWSKGSPLPISHYGGCAIY 435
PHA03098 PHA03098
kelch-like protein; Provisional
 220-328 4.19e-16

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 79.04  E-value: 4.19e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21732361  220 RGGVGVATYNGFLYVVGGHDApaSNHCSrlsDCVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGYDGHTYLNT 299
Cdd:PHA03098 285 VYCFGSVVLNNVIYFIGGMNK--NNLSV---NSVVSYDTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGIYNSISLNT 359

                         90       100
                 ....*....|....*....|....*....
gi 21732361  300 VESYDAQRNEWKEEVPVNIGRAGACVVVV 328
Cdd:PHA03098 360 VESWKPGESKWREEPPLIFPRYNPCVVNV 388
Kelch smart00612
Kelch domain;
184-230 1.63e-15

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 69.51  E-value: 1.63e-15
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 21732361    184 KLYAIGGRDGSSCLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNG 230
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 78-123 4.08e-13

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 63.01  E-value: 4.08e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 21732361    78 RRLQFGVAVIDNKLYVVGGRDGLKTLNTVECFNPVGKIWTVMPPMS 123
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
Kelch smart00612
Kelch domain;
139-183 5.72e-13

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 62.58  E-value: 5.72e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 21732361    139 YAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNN 183
Cdd:smart00612   3 YVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 172-217 6.78e-13

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 62.24  E-value: 6.78e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 21732361   172 PRSTVGVVALNNKLYAIGGRDGSSCLKSMEYFDPHTNKWSLCAPMS 217
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
PHA02790 PHA02790
Kelch-like protein; Provisional
 91-310 9.05e-13

Kelch-like protein; Provisional


Pssm-ID: 165153 [Multi-domain]  Cd Length: 480  Bit Score: 68.53  E-value: 9.05e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21732361   91 LYVVGGRDGLKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHDGWSylnTVERWDPEGRQWNYVASMS 170
Cdd:PHA02790 274 VYLIGGWMNNEIHNNAIAVNYISNNWIPIPPMNSPRLYASGVPANNKLYVVGGLPNPT---SVERWFHGDAAWVNMPSLL 350

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21732361  171 TPRSTVGVVALNNKLYAIGGRdgSSCLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHdapasnhcsrls 250
Cdd:PHA02790 351 KPRCNPAVASINNVIYVIGGH--SETDTTTEYLLPNHDQWQFGPSTYYPHYKSCALVFGRRLFLVGRN------------ 416

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 21732361  251 dcVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGYDGHTYLNTVESYDAQRNEW 310
Cdd:PHA02790 417 --AEFYCESSNTWTLIDDPIYPRDNPELIIVDNKLLLIGGFYRGSYIDTIEVYNNRTYSW 474
PLN02193 PLN02193
nitrile-specifier protein
 77-290 1.53e-12

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 68.06  E-value: 1.53e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21732361   77 GRRLQFGVAVIDNKLYVVGGRdglKTLNT-----VECFNPVGKIWTVMPPMSTHRH----GLGVATLEGPMYAVGGHDGW 147
Cdd:PLN02193 164 GLRCSHGIAQVGNKIYSFGGE---FTPNQpidkhLYVFDLETRTWSISPATGDVPHlsclGVRMVSIGSTLYVFGGRDAS 240

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21732361  148 SYLNTVERWDPEGRQWNYVASMS---TPRSTVGVVALNNKLYAIGGRDGSSCLKSMEYFDPHTNKWSLCAPMSKR---RG 221
Cdd:PLN02193 241 RQYNGFYSFDTTTNEWKLLTPVEegpTPRSFHSMAADEENVYVFGGVSATARLKTLDSYNIVDKKWFHCSTPGDSfsiRG 320

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 21732361  222 GVGVATYNGFLYVVGGHdapasNHCSrlSDCVERYDPKGDSWSTVAPLSV---PRDAVAVCPLGDKLYVVGG 290
Cdd:PLN02193 321 GAGLEVVQGKVWVVYGF-----NGCE--VDDVHYYDPVQDKWTQVETFGVrpsERSVFASAAVGKHIVIFGG 385
Kelch smart00612
Kelch domain;
90-136 1.60e-12

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 61.04  E-value: 1.60e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 21732361     90 KLYVVGGRDGLKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEG 136
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
PHA02713 PHA02713
hypothetical protein; Provisional
 62-191 3.80e-11

hypothetical protein; Provisional


Pssm-ID: 165086 [Multi-domain]  Cd Length: 557  Bit Score: 63.88  E-value: 3.80e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21732361   62 YDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGGRD-GLKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYA 140
Cdd:PHA02713 277 YNINTMEYSVISTIPNHIINYASAIVDNEIIIAGGYNfNNPSLNKVYKINIENKIHVELPPMIKNRCRFSLAVIDDTIYA 356

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 21732361  141 VGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGR 191
Cdd:PHA02713 357 IGGQNGTNVERTIECYTMGDDKWKMLPDMPIALSSYGMCVLDQYIYIIGGR 407
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 125-170 4.48e-11

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 57.24  E-value: 4.48e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 21732361   125 HRHGLGVATLEGPMYAVGGHDGWSYLNTVERWDPEGRQWNYVASMS 170
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
Kelch smart00612
Kelch domain;
284-328 6.86e-11

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 56.80  E-value: 6.86e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 21732361    284 KLYVVGGYDGHTYLNTVESYDAQRNEWKEEVPVNIGRAGACVVVV 328
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVI 45
PHA02790 PHA02790
Kelch-like protein; Provisional
 66-264 9.69e-10

Kelch-like protein; Provisional


Pssm-ID: 165153 [Multi-domain]  Cd Length: 480  Bit Score: 59.29  E-value: 9.69e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21732361   66 TNSWLHIGTMNGRRLQFGVAVIDNKLYVVGgrdGLKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHD 145
Cdd:PHA02790 296 SNNWIPIPPMNSPRLYASGVPANNKLYVVG---GLPNPTSVERWFHGDAAWVNMPSLLKPRCNPAVASINNVIYVIGGHS 372

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21732361  146 GWSylNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGgrdgssclKSMEYFDPHTNKWSLCAPMSKRRGGVGV 225
Cdd:PHA02790 373 ETD--TTTEYLLPNHDQWQFGPSTYYPHYKSCALVFGRRLFLVG--------RNAEFYCESSNTWTLIDDPIYPRDNPEL 442

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 21732361  226 ATYNGFLYVVGGHdapasnHCSRLSDCVERYDPKGDSWS 264
Cdd:PHA02790 443 IIVDNKLLLIGGF------YRGSYIDTIEVYNNRTYSWN 475
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 272-312 9.49e-09

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 50.69  E-value: 9.49e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 21732361   272 PRDAVAVCPLGDKLYVVGGYDGHTYLNTVESYDAQRNEWKE 312
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSK 41
Kelch smart00612
Kelch domain;
44-89 1.34e-08

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 50.25  E-value: 1.34e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 21732361     44 LYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNGRRLQFGVAVIDN 89
Cdd:smart00612   2 IYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
Kelch smart00612
Kelch domain;
232-283 2.37e-08

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 49.48  E-value: 2.37e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 21732361    232 LYVVGGHDaPASNHCSrlsdcVERYDPKGDSWSTVAPLSVPRDAVAVCPLGD 283
Cdd:smart00612   2 IYVVGGFD-GGQRLKS-----VEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 219-270 3.80e-08

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 48.76  E-value: 3.80e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 21732361   219 RRGGVGVATYNGFLYVVGGHDApasnhcSRLSDCVERYDPKGDSWSTVAPLS 270
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDG------NQSLNSVEVYDPETNTWSKLPSMP 46
PRK14131 PRK14131
N-acetylneuraminate epimerase;
177-326 2.29e-07

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 51.94  E-value: 2.29e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21732361  177 GVVAL-NNKLYaIG-GRDGSSCLKsMEYFDPHtNKWSLCA--PMSKRRGGVGVATyNGFLYVVGGHDAPASNHCSRLSDC 252
Cdd:PRK14131  32 GTGAIdNNTVY-VGlGSAGTSWYK-LDLNAPS-KGWTKIAafPGGPREQAVAAFI-DGKLYVFGGIGKTNSEGSPQVFDD 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21732361  253 VERYDPKGDSWSTVAPLSvPRD---AVAVCPLGDKLYVVGGY-----DGH-------------------TYLNT------ 299
Cdd:PRK14131 108 VYKYDPKTNSWQKLDTRS-PVGlagHVAVSLHNGKAYITGGVnknifDGYfedlaaagkdktpkdkindAYFDKkpedyf 186

                        170       180       190
                 ....*....|....*....|....*....|...
gi 21732361  300 ----VESYDAQRNEWKE--EVPVnIGRAGACVV 326
Cdd:PRK14131 187 fnkeVLSYDPSTNQWKNagESPF-LGTAGSAVV 218
PLN02193 PLN02193
nitrile-specifier protein
 24-190 4.66e-07

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 51.11  E-value: 4.66e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21732361   24 ERRSMMQSPRTK--PRKSTVG--------ALYAVGGMDAMKGTTTIEKYDLRTNSW-LHIGTMNG--RRLQFGVAVIDNK 90
Cdd:PLN02193 201 ETRTWSISPATGdvPHLSCLGvrmvsigsTLYVFGGRDASRQYNGFYSFDTTTNEWkLLTPVEEGptPRSFHSMAADEEN 280

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21732361   91 LYVVGGRDGLKTLNTVECFNPVGKIW--TVMPPMS-THRHGLGVATLEGPMYAVGGHDGWSyLNTVERWDPEGRQWNYVA 167
Cdd:PLN02193 281 VYVFGGVSATARLKTLDSYNIVDKKWfhCSTPGDSfSIRGGAGLEVVQGKVWVVYGFNGCE-VDDVHYYDPVQDKWTQVE 359

                        170       180
                 ....*....|....*....|....*.
gi 21732361  168 SMS---TPRSTVGVVALNNKLYAIGG 190
Cdd:PLN02193 360 TFGvrpSERSVFASAAVGKHIVIFGG 385
Kelch_6 pfam13964
Kelch motif;
225-273 6.13e-06

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 42.71  E-value: 6.13e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 21732361   225 VATYNGFLYVVGGhdapaSNHCSRLSDCVERYDPKGDSWSTVAPLSVPR 273
Cdd:pfam13964   7 VVSVGGYIYVFGG-----YTNASPALNKLEVYNPLTKSWEELPPLPTPR 50
PLN02153 PLN02153
epithiospecifier protein
 27-180 1.07e-05

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 46.52  E-value: 1.07e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21732361   27 SMMQSPRTKPRKSTVGA--------LYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNGR-----RLQFGVAVIDNKLYV 93
Cdd:PLN02153  63 SIAPANGDVPRISCLGVrmvavgtkLYIFGGRDEKREFSDFYSYDTVKNEWTFLTKLDEEggpeaRTFHSMASDENHVYV 142

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21732361   94 VGG--RDGLKT----LNTVECFNPVGKIWTVMPPMSTH---RHGLGVATLEGPMYAV---------GGHDGWSYlNTVER 155
Cdd:PLN02153 143 FGGvsKGGLMKtperFRTIEAYNIADGKWVQLPDPGENfekRGGAGFAVVQGKIWVVygfatsilpGGKSDYES-NAVQF 221

                        170       180
                 ....*....|....*....|....*
gi 21732361  156 WDPEGRQWNYVASMSTPRSTVGVVA 180
Cdd:PLN02153 222 FDPASGKWTEVETTGAKPSARSVFA 246
Kelch_6 pfam13964
Kelch motif;
79-122 1.07e-05

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 42.32  E-value: 1.07e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 21732361    79 RLQFGVAVIDNKLYVVGGR-DGLKTLNTVECFNPVGKIWTVMPPM 122
Cdd:pfam13964   2 RTFHSVVSVGGYIYVFGGYtNASPALNKLEVYNPLTKSWEELPPL 46
PLN02153 PLN02153
epithiospecifier protein
 32-266 1.26e-05

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 46.52  E-value: 1.26e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21732361   32 PRTKPRKSTVG-ALYAVGGmdAMKGTTTIEK----YDLRTNSWlHIGTMNG---RRLQFGV--AVIDNKLYVVGGRDGLK 101
Cdd:PLN02153  22 PRCSHGIAVVGdKLYSFGG--ELKPNEHIDKdlyvFDFNTHTW-SIAPANGdvpRISCLGVrmVAVGTKLYIFGGRDEKR 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21732361  102 TLNTVECFNPVGKIWTVMPPMSThrhglgvatlegpmyaVGGhdgwsylntverwdPEGRQWNYVASMStprstvgvval 181
Cdd:PLN02153  99 EFSDFYSYDTVKNEWTFLTKLDE----------------EGG--------------PEARTFHSMASDE----------- 137

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21732361  182 nNKLYAIGGRDGSSCLK------SMEYFDPHTNKW-SLCAPMS--KRRGGVGVATYNGFLYVV---------GGHDAPAS 243
Cdd:PLN02153 138 -NHVYVFGGVSKGGLMKtperfrTIEAYNIADGKWvQLPDPGEnfEKRGGAGFAVVQGKIWVVygfatsilpGGKSDYES 216

                        250       260
                 ....*....|....*....|...
gi 21732361  244 NhcsrlsdCVERYDPKGDSWSTV 266
Cdd:PLN02153 217 N-------AVQFFDPASGKWTEV 232
PLN02193 PLN02193
nitrile-specifier protein
 130-312 1.55e-05

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 46.49  E-value: 1.55e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21732361  130 GVATLEGPMYAVGGH-------DGWSYLntverWDPEGRQWNYV-ASMSTPR-STVGV--VALNNKLYAIGGRDGSSCLK 198
Cdd:PLN02193 170 GIAQVGNKIYSFGGEftpnqpiDKHLYV-----FDLETRTWSISpATGDVPHlSCLGVrmVSIGSTLYVFGGRDASRQYN 244

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21732361  199 SMEYFDPHTNKWSLCAPMSK---RRGGVGVATYNGFLYVVGGHDAPAsnhcsRLsDCVERYDPKGDSW---STVAPLSVP 272
Cdd:PLN02193 245 GFYSFDTTTNEWKLLTPVEEgptPRSFHSMAADEENVYVFGGVSATA-----RL-KTLDSYNIVDKKWfhcSTPGDSFSI 318

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 21732361  273 RDAVAVCPLGDKLYVVGGYDGhTYLNTVESYDAQRNEWKE 312
Cdd:PLN02193 319 RGGAGLEVVQGKVWVVYGFNG-CEVDDVHYYDPVQDKWTQ 357
PRK14131 PRK14131
N-acetylneuraminate epimerase;
130-316 2.66e-05

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 45.39  E-value: 2.66e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21732361  130 GVATLEGPMYAVG---GHDGWSYLNTverwDPEGRQWNYVASM-STPRSTVGVVALNNKLYAIGG-----RDGSSCLKSM 200
Cdd:PRK14131  32 GTGAIDNNTVYVGlgsAGTSWYKLDL----NAPSKGWTKIAAFpGGPREQAVAAFIDGKLYVFGGigktnSEGSPQVFDD 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21732361  201 EY-FDPHTNKWSLCAPMSKR--RGGVGVATYNGFLYVVGGH-----------------DAPASNHCSR-----------L 249
Cdd:PRK14131 108 VYkYDPKTNSWQKLDTRSPVglAGHVAVSLHNGKAYITGGVnknifdgyfedlaaagkDKTPKDKINDayfdkkpedyfF 187

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 21732361  250 SDCVERYDPKGDSWS--TVAPLSvPRDAVAVCPLGDKLYVVGGyDGHTYLNTVESY----DAQRNEWKEEVPV 316
Cdd:PRK14131 188 NKEVLSYDPSTNQWKnaGESPFL-GTAGSAVVIKGNKLWLING-EIKPGLRTDAVKqgkfTGNNLKWQKLPDL 258
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 42-76 4.02e-05

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 40.29  E-value: 4.02e-05
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 21732361    42 GALYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMN 76
Cdd:pfam01344  12 GKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
Kelch_6 pfam13964
Kelch motif;
172-220 9.05e-05

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 39.63  E-value: 9.05e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 21732361   172 PRSTVGVVALNNKLYAIGGR-DGSSCLKSMEYFDPHTNKWSLCAPMSKRR 220
Cdd:pfam13964   1 PRTFHSVVSVGGYIYVFGGYtNASPALNKLEVYNPLTKSWEELPPLPTPR 50
Kelch_6 pfam13964
Kelch motif;
272-320 3.70e-04

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 37.70  E-value: 3.70e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 21732361   272 PRDAVAVCPLGDKLYVVGGY-DGHTYLNTVESYDAQRNEWKEEVPVNIGR 320
Cdd:pfam13964   1 PRTFHSVVSVGGYIYVFGGYtNASPALNKLEVYNPLTKSWEELPPLPTPR 50
PHA02713 PHA02713
hypothetical protein; Provisional
 44-141 4.92e-04

hypothetical protein; Provisional


Pssm-ID: 165086 [Multi-domain]  Cd Length: 557  Bit Score: 41.92  E-value: 4.92e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21732361   44 LYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGGRD------GLKTLNTVEC--------- 108
Cdd:PHA02713 354 IYAIGGQNGTNVERTIECYTMGDDKWKMLPDMPIALSSYGMCVLDQYIYIIGGRTehidytSVHHMNSIDMeedthssnk 433

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 21732361  109 ---FNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAV 141
Cdd:PHA02713 434 virYDTVNNIWETLPNFWTGTIRPGVVSHKDDIYVV 469
Kelch_6 pfam13964
Kelch motif;
125-173 6.42e-04

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 37.31  E-value: 6.42e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 21732361   125 HRHGLGVATLEGPMYAVGG-HDGWSYLNTVERWDPEGRQWNYVASMSTPR 173
Cdd:pfam13964   1 PRTFHSVVSVGGYIYVFGGyTNASPALNKLEVYNPLTKSWEELPPLPTPR 50
Kelch_4 pfam13418
Galactose oxidase, central domain;
219-269 6.56e-04

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 37.21  E-value: 6.56e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 21732361   219 RRGGVGVATYNGFLYVVGGHDAPAsnhcSRLSDCvERYDPKGDSWSTVAPL 269
Cdd:pfam13418   2 RAYHTSTSIPDDTIYLFGGEGEDG----TLLSDL-WVFDLSTNEWTRLGSL 47
Kelch_2 pfam07646
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 272-312 1.08e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 462220 [Multi-domain]  Cd Length: 47  Bit Score: 36.55  E-value: 1.08e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 21732361   272 PRDAVAVCPLGDKLYVVGGYDGH--TYLNTVESYDAQRNEWKE 312
Cdd:pfam07646   1 PRYPHASSVPGGKLYVVGGSDGLgdLSSSDVLVYDPETNVWTE 43
Kelch_4 pfam13418
Galactose oxidase, central domain;
77-122 1.83e-03

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 35.67  E-value: 1.83e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 21732361    77 GRRLQFGVAVIDNKLYVVGGRDGL-KTLNTVECFNPVGKIWTVMPPM 122
Cdd:pfam13418   1 PRAYHTSTSIPDDTIYLFGGEGEDgTLLSDLWVFDLSTNEWTRLGSL 47
Kelch_2 pfam07646
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 78-122 2.38e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 462220 [Multi-domain]  Cd Length: 47  Bit Score: 35.39  E-value: 2.38e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 21732361    78 RRLQFGVAVIDNKLYVVGGRDGLK--TLNTVECFNPVGKIWTVMPPM 122
Cdd:pfam07646   1 PRYPHASSVPGGKLYVVGGSDGLGdlSSSDVLVYDPETNVWTEVPRL 47
Kelch_3 pfam13415
Galactose oxidase, central domain;
282-328 3.35e-03

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 34.96  E-value: 3.35e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 21732361   282 GDKLYVVGGYD--GHTYLNTVESYDAQRNEWKEEVPVNIGRAGACVVVV 328
Cdd:pfam13415   1 GDKLYIFGGLGfdGQTRLNDLYVYDLDTNTWTQIGDLPPPRSGHSATYI 49
Kelch_2 pfam07646
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 172-216 6.07e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 462220 [Multi-domain]  Cd Length: 47  Bit Score: 34.23  E-value: 6.07e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 21732361   172 PRSTVGVVALNNKLYAIGGRDGSSCLKSME--YFDPHTNKWSLCAPM 216
Cdd:pfam07646   1 PRYPHASSVPGGKLYVVGGSDGLGDLSSSDvlVYDPETNVWTEVPRL 47
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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