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Conserved domains on  [gi|1901201836|emb|CAD5336118|]
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unnamed protein product [Arabidopsis thaliana]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BTB_POZ_BT cd18313
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 59-160 2.00e-61

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana BTB/POZ and TAZ domain-containing proteins, BT1-5; BT1-5 may act as substrate-specific adaptors of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. They contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


:

Pssm-ID: 349622 [Multi-domain]  Cd Length: 102  Bit Score: 192.31  E-value: 2.00e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1901201836  59 KADVVIYTDNGSIIYAHANILGTASTVIKGMLKQAKRHGKWHTISIRGVPHDAVRVFIRFLYSSCYEKEEMNEFIMHLLL 138
Cdd:cd18313     1 GADVEIETDNNSHIPAHSNVLASASPVIAGMLKQPRRKSSKKVIKILGVPCDAVRVFIRFLYSSCYEEEEMEKFGIHLLV 80

                          90       100
                  ....*....|....*....|..
gi 1901201836 139 LSHAYVVPQLKRVCEWHLEHGL 160
Cdd:cd18313    81 LSHVYVVPQLKRVCEKGLEQGL 102
ZnF_TAZ smart00551
TAZ zinc finger, present in p300 and CBP;
237-330 5.35e-21

TAZ zinc finger, present in p300 and CBP;


:

Pssm-ID: 214717  Cd Length: 79  Bit Score: 85.88  E-value: 5.35e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1901201836  237 QRIYSQLYEAMEALVHICRdgCKTIGphdkdfkpnhATCNYEACKGLESLIRHFAGCKLR--VPGGCVHCKRMWQllelH 314
Cdd:smart00551   1 QTRYKQLQRWLELLVHARR--CKARE----------AKCQYPNCKTMKKLLRHMDSCKVRkcKYGYCASCKQLWQ----H 64

                           90
                   ....*....|....*.
gi 1901201836  315 SRVCAGSDqCRVPLCR 330
Cdd:smart00551  65 SKHCKDSN-CPVCKCV 79
BACK super family cl28903
BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal ...
 161-216 8.25e-05

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal to a BTB domain, in a diverse set of architectures together with Kelch, MATH, and/or TAZ domains. It is involved in interactions with the Cullin3 (Cul3) ubiquitin ligase complex, as well as in homo-oligomerization. Most proteins containing the BACK domain are understood to function as adaptor proteins that play a role in ubiquitination of various substrates.


The actual alignment was detected with superfamily member cd14821:

Pssm-ID: 475122  Cd Length: 59  Bit Score: 40.07  E-value: 8.25e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1901201836 161 LTTENVVDVFQLALLCDFPRLSLISHRMIMKHFNELSATEAWTAMKKSHPFLEKEV 216
Cdd:cd14821     1 LSVENAAEVLVLADLHSAEQLKTHAIDFINSHATDVMETEGWKSMVRSHPHLVAEA 56
 
Name Accession Description Interval E-value
BTB_POZ_BT cd18313
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 59-160 2.00e-61

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana BTB/POZ and TAZ domain-containing proteins, BT1-5; BT1-5 may act as substrate-specific adaptors of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. They contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349622 [Multi-domain]  Cd Length: 102  Bit Score: 192.31  E-value: 2.00e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1901201836  59 KADVVIYTDNGSIIYAHANILGTASTVIKGMLKQAKRHGKWHTISIRGVPHDAVRVFIRFLYSSCYEKEEMNEFIMHLLL 138
Cdd:cd18313     1 GADVEIETDNNSHIPAHSNVLASASPVIAGMLKQPRRKSSKKVIKILGVPCDAVRVFIRFLYSSCYEEEEMEKFGIHLLV 80

                          90       100
                  ....*....|....*....|..
gi 1901201836 139 LSHAYVVPQLKRVCEWHLEHGL 160
Cdd:cd18313    81 LSHVYVVPQLKRVCEKGLEQGL 102
ZnF_TAZ smart00551
TAZ zinc finger, present in p300 and CBP;
237-330 5.35e-21

TAZ zinc finger, present in p300 and CBP;


Pssm-ID: 214717  Cd Length: 79  Bit Score: 85.88  E-value: 5.35e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1901201836  237 QRIYSQLYEAMEALVHICRdgCKTIGphdkdfkpnhATCNYEACKGLESLIRHFAGCKLR--VPGGCVHCKRMWQllelH 314
Cdd:smart00551   1 QTRYKQLQRWLELLVHARR--CKARE----------AKCQYPNCKTMKKLLRHMDSCKVRkcKYGYCASCKQLWQ----H 64

                           90
                   ....*....|....*.
gi 1901201836  315 SRVCAGSDqCRVPLCR 330
Cdd:smart00551  65 SKHCKDSN-CPVCKCV 79
zf-TAZ pfam02135
TAZ zinc finger; The TAZ2 domain of CBP binds to other transcription factors such as the p53 ...
 243-326 2.49e-13

TAZ zinc finger; The TAZ2 domain of CBP binds to other transcription factors such as the p53 tumour suppressor protein, E1A oncoprotein, MyoD, and GATA-1. The zinc coordinating motif that is necessary for binding to target DNA sequences consists of HCCC.


Pssm-ID: 460457  Cd Length: 72  Bit Score: 64.33  E-value: 2.49e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1901201836 243 LYEAMEALVHICRdgCKTIGPhdkdfkpnhATCNYEACKGLESLIRHFAGCKLRVPGGCVHCKRMWQLLElHSRVCAGSD 322
Cdd:pfam02135   1 LQRWLLLLLHASK--CSAPGP---------GPCSLPNCRKMKRLLRHMATCKRGGGCPYPHCKRSRQLLR-HAKNCKDED 68


                  ....
gi 1901201836 323 qCRV 326
Cdd:pfam02135  69 -CPV 71
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 61-160 1.29e-10

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 57.70  E-value: 1.29e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1901201836   61 DVVIYTDnGSIIYAHANILGTASTVIKGMLKQAKRHGKWHTISIRGVPHDAVRVFIRFLYSscYEKEEMNEFIMHLLLLS 140
Cdd:smart00225   1 DVTLVVG-GKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDDVSPEDFRALLNFLYT--GKLDLPEENVEELLELA 77

                           90       100
                   ....*....|....*....|
gi 1901201836  141 HAYVVPQLKRVCEWHLEHGL 160
Cdd:smart00225  78 DYLQIPGLVELCEEFLLKLL 97
BACK_SPOP_like cd14821
BACK (BTB and C-terminal Kelch) domain found in speckle-type POZ protein (SPOP) and similar ...
 161-216 8.25e-05

BACK (BTB and C-terminal Kelch) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill, and similar proteins. Both SPOP and SPOPL serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domain. TDPOZ proteins may be nuclear scaffold proteins involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also termed Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor.


Pssm-ID: 350517  Cd Length: 59  Bit Score: 40.07  E-value: 8.25e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1901201836 161 LTTENVVDVFQLALLCDFPRLSLISHRMIMKHFNELSATEAWTAMKKSHPFLEKEV 216
Cdd:cd14821     1 LSVENAAEVLVLADLHSAEQLKTHAIDFINSHATDVMETEGWKSMVRSHPHLVAEA 56
 
Name Accession Description Interval E-value
BTB_POZ_BT cd18313
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 59-160 2.00e-61

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana BTB/POZ and TAZ domain-containing proteins, BT1-5; BT1-5 may act as substrate-specific adaptors of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. They contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349622 [Multi-domain]  Cd Length: 102  Bit Score: 192.31  E-value: 2.00e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1901201836  59 KADVVIYTDNGSIIYAHANILGTASTVIKGMLKQAKRHGKWHTISIRGVPHDAVRVFIRFLYSSCYEKEEMNEFIMHLLL 138
Cdd:cd18313     1 GADVEIETDNNSHIPAHSNVLASASPVIAGMLKQPRRKSSKKVIKILGVPCDAVRVFIRFLYSSCYEEEEMEKFGIHLLV 80

                          90       100
                  ....*....|....*....|..
gi 1901201836 139 LSHAYVVPQLKRVCEWHLEHGL 160
Cdd:cd18313    81 LSHVYVVPQLKRVCEKGLEQGL 102
ZnF_TAZ smart00551
TAZ zinc finger, present in p300 and CBP;
237-330 5.35e-21

TAZ zinc finger, present in p300 and CBP;


Pssm-ID: 214717  Cd Length: 79  Bit Score: 85.88  E-value: 5.35e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1901201836  237 QRIYSQLYEAMEALVHICRdgCKTIGphdkdfkpnhATCNYEACKGLESLIRHFAGCKLR--VPGGCVHCKRMWQllelH 314
Cdd:smart00551   1 QTRYKQLQRWLELLVHARR--CKARE----------AKCQYPNCKTMKKLLRHMDSCKVRkcKYGYCASCKQLWQ----H 64

                           90
                   ....*....|....*.
gi 1901201836  315 SRVCAGSDqCRVPLCR 330
Cdd:smart00551  65 SKHCKDSN-CPVCKCV 79
zf-TAZ pfam02135
TAZ zinc finger; The TAZ2 domain of CBP binds to other transcription factors such as the p53 ...
 243-326 2.49e-13

TAZ zinc finger; The TAZ2 domain of CBP binds to other transcription factors such as the p53 tumour suppressor protein, E1A oncoprotein, MyoD, and GATA-1. The zinc coordinating motif that is necessary for binding to target DNA sequences consists of HCCC.


Pssm-ID: 460457  Cd Length: 72  Bit Score: 64.33  E-value: 2.49e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1901201836 243 LYEAMEALVHICRdgCKTIGPhdkdfkpnhATCNYEACKGLESLIRHFAGCKLRVPGGCVHCKRMWQLLElHSRVCAGSD 322
Cdd:pfam02135   1 LQRWLLLLLHASK--CSAPGP---------GPCSLPNCRKMKRLLRHMATCKRGGGCPYPHCKRSRQLLR-HAKNCKDED 68


                  ....
gi 1901201836 323 qCRV 326
Cdd:pfam02135  69 -CPV 71
BTB_POZ_ZBTB_KLHL-like cd18186
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 60-143 2.33e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349497 [Multi-domain]  Cd Length: 82  Bit Score: 62.19  E-value: 2.33e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1901201836  60 ADVVIYTDnGSIIYAHANILGTASTVIKGMLKQAKRHGKWHTISIRGVPHDAVRVFIRFLYSSCYEKEEmnEFIMHLLLL 139
Cdd:cd18186     2 CDVTLVVG-GREFPAHRAVLAARSPYFRAMFSSGMKESSSSEIELDDVSPEAFEALLDYIYTGELELSE--ENVEELLAA 78


                  ....
gi 1901201836 140 SHAY 143
Cdd:cd18186    79 ADKL 82
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 61-160 1.29e-10

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 57.70  E-value: 1.29e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1901201836   61 DVVIYTDnGSIIYAHANILGTASTVIKGMLKQAKRHGKWHTISIRGVPHDAVRVFIRFLYSscYEKEEMNEFIMHLLLLS 140
Cdd:smart00225   1 DVTLVVG-GKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDDVSPEDFRALLNFLYT--GKLDLPEENVEELLELA 77

                           90       100
                   ....*....|....*....|
gi 1901201836  141 HAYVVPQLKRVCEWHLEHGL 160
Cdd:smart00225  78 DYLQIPGLVELCEEFLLKLL 97
BTB_POZ_ABTB2-like cd18297
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 69-165 6.12e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349606 [Multi-domain]  Cd Length: 117  Bit Score: 56.13  E-value: 6.12e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1901201836  69 GSIIYAHANILGTASTVIKGMLKQAKRHGKWHTISIRGVPHDAVRVFIRFLYSSCYEKEEMN-EFIMHLLLLSHAYVVPQ 147
Cdd:cd18297    21 GRPFYAHKIVLVTASDRFKSMLSSGSTEAQTPVIEIPDIRYDIFQLMMQYLYTGGVESLDVAqDDALELLRAASFFQLDG 100

                          90
                  ....*....|....*...
gi 1901201836 148 LKRVCEWHLEhGLLTTEN 165
Cdd:cd18297   101 LKRHCEILLS-QQIDLDN 117
BTB2_POZ_BTBD8 cd18286
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 52-156 2.95e-07

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349595 [Multi-domain]  Cd Length: 121  Bit Score: 48.79  E-value: 2.95e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1901201836  52 RLFNDGYKADVVIYTDNGSiIYAHANILGTASTVIKGMLKqakrhGKW-----HTISIRGVPHDAVRVFIRFLYSSCYEk 126
Cdd:cd18286    10 QLFLNGEDSDITIKVDGKT-FKAHRCILCARSSYFAAMLS-----GSWaesnsSEITLTGVSHAAVSFVLLFIYGGVLD- 82

                          90       100       110
                  ....*....|....*....|....*....|
gi 1901201836 127 EEMNEFIMHLLLLSHAYVVPQLKRVCEWHL 156
Cdd:cd18286    83 LPDDVNLGELLSLADMYGLDGLKDVVAYTL 112
BTB_POZ_BTBD19 cd18294
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 52-153 4.38e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349603 [Multi-domain]  Cd Length: 111  Bit Score: 48.01  E-value: 4.38e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1901201836  52 RLFNDGYKADVV-IYTDNGSIIYAHANILGTASTVIKGML-KQAKRHGKWHTISIRGVPHDAVRVFIRFLYSSCYekEEM 129
Cdd:cd18294     7 SLINNPEFSDVKfLVGPERQEIFAHKCILAARCEVFRAMFlTGPQKESTQSPLVLSDIEPEVFRAVLEFIYTNCV--TLS 84

                          90       100
                  ....*....|....*....|....
gi 1901201836 130 NEFIMHLLLLSHAYVVPQLKRVCE 153
Cdd:cd18294    85 NHTVIEVLAAAVEYGLDELRKLCE 108
BTB_POZ_RCBTB1_2 cd18298
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 52-158 6.58e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2; The RCC1-related guanine nucleotide exchange factor (GEF) family includes RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2, both of which are chromosome condensation regulator-like guanine nucleotide exchange factors. They contain an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349607 [Multi-domain]  Cd Length: 108  Bit Score: 44.55  E-value: 6.58e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1901201836  52 RLFNDGYKADVVIYTDnGSIIYAHANILGTASTVIKGMLKQAKRHGKWHTISIRGVPHDAVRVFIRFLYSSCYEKEEmnE 131
Cdd:cd18298     5 KAFNDPRTSDLKFRVD-GKYIYVHKAILKIRCEYFRSMFQSHWNEDDKNVIEIDQYSYPVYYAFLRYLYTDQVDLPP--E 81

                          90       100
                  ....*....|....*....|....*..
gi 1901201836 132 FIMHLLLLSHAYVVPQLKRVCEWHLEH 158
Cdd:cd18298    82 DAIGLLDLANSYCEERLKKLCEDIIKQ 108
BACK_SPOP_like cd14821
BACK (BTB and C-terminal Kelch) domain found in speckle-type POZ protein (SPOP) and similar ...
 161-216 8.25e-05

BACK (BTB and C-terminal Kelch) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill, and similar proteins. Both SPOP and SPOPL serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domain. TDPOZ proteins may be nuclear scaffold proteins involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also termed Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor.


Pssm-ID: 350517  Cd Length: 59  Bit Score: 40.07  E-value: 8.25e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1901201836 161 LTTENVVDVFQLALLCDFPRLSLISHRMIMKHFNELSATEAWTAMKKSHPFLEKEV 216
Cdd:cd14821     1 LSVENAAEVLVLADLHSAEQLKTHAIDFINSHATDVMETEGWKSMVRSHPHLVAEA 56
BTB_POZ_KBTBD8 cd18274
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 53-152 3.91e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralog TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349583 [Multi-domain]  Cd Length: 129  Bit Score: 39.97  E-value: 3.91e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1901201836  53 LFNDGYKADVVIYTDNGSIIYAHANILGTASTVIKGMLKQAKRHGKWHTISIRGVPHDAVRVFIRFLYSSCYEKEEMNef 132
Cdd:cd18274    16 MYDEGQLTDIVVEVDHGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMHLVLDYAYTSRVTLTEAN-- 93

                          90       100
                  ....*....|....*....|
gi 1901201836 133 IMHLLLLSHAYVVPQLKRVC 152
Cdd:cd18274    94 VQALFTAASIFQIPSLQDQC 113
BTB_POZ_BTBD1_2 cd18281
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 53-160 6.45e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD1 and BTBD2; This family includes BTB/POZ domain-containing proteins BTBD1 and BTBD2, both of which are BTB-domain-containing Kelch-like proteins that interact with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349590 [Multi-domain]  Cd Length: 127  Bit Score: 39.34  E-value: 6.45e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1901201836  53 LFNDGYKADV---VIYTDNGSIIYAHANILGTASTVIKGMLKQAKRHgKWHTISIRGVPHDAVRVFIRFLYSScyEKEEM 129
Cdd:cd18281    16 LFNNETLSDVhfiVGKGDNEQRIPAHKFVLSIGSAVFDAMFNGGMAT-TSAEIELPDVEPAAFLALLRFLYSD--EVQIG 92

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1901201836 130 NEFIMHLLLLSHAYVVPQLKRVCEWHLEHGL 160
Cdd:cd18281    93 PETVMTTLYTAKKYAVPALESACVEFLKKNL 123
BACK cd14733
BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal ...
 162-205 6.70e-04

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal to a BTB domain, in a diverse set of architectures together with Kelch, MATH, and/or TAZ domains. It is involved in interactions with the Cullin3 (Cul3) ubiquitin ligase complex, as well as in homo-oligomerization. Most proteins containing the BACK domain are understood to function as adaptor proteins that play a role in ubiquitination of various substrates.


Pssm-ID: 350515 [Multi-domain]  Cd Length: 55  Bit Score: 37.26  E-value: 6.70e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1901201836 162 TTENVVDVFQLALLCDFPRLSLISHRMIMKHFNELSATEAWTAM 205
Cdd:cd14733     1 DPENCLGILELADLYNLEELKEKALKFILENFEEVSKSEEFLEL 44
BTB_POZ_BTBD17 cd18292
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 52-153 1.35e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349601 [Multi-domain]  Cd Length: 114  Bit Score: 38.04  E-value: 1.35e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1901201836  52 RLFNDGYKADVVIyTDNGSIIYAHANILGTASTVIKGMLKQakrhgKWHTISIRGV-----PHDAVRV---FIRFLYSSC 123
Cdd:cd18292    10 QLYNNEELSDIVL-RVGGKVFHAHRLILAKSSDVFRVMLSN-----DWWSESKQSEielveDPECAAVfekFLRYLYTGQ 83

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1901201836 124 YekeEMN-EFIMHLLLLSHAYVVPQLKRVCE 153
Cdd:cd18292    84 I---SVNlETALPLLMLADKYNVTDLKQLCV 111
BTB_POZ_BAB-like cd18315
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 59-133 3.23e-03

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349624 [Multi-domain]  Cd Length: 85  Bit Score: 36.37  E-value: 3.23e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1901201836  59 KADVVIYTDnGSIIYAHANILGTASTVIKGMLKQAKRHGkwHT-ISIRGVPHDAVRVFIRFLYSS--CYEKEEMNEFI 133
Cdd:cd18315     1 LVDVTLACE-GGSLKAHKLVLAAASPYFAALLKETPPDE--HPvIILPDVPYSELKALLDFIYTGevNVSQEQLESLL 75
BTB_POZ_KLHL19_KEAP1 cd18248
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 61-160 4.50e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also called cytosolic inhibitor of Nrf2 (INrf2) or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349557 [Multi-domain]  Cd Length: 124  Bit Score: 36.97  E-value: 4.50e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1901201836  61 DVVI---YTDNGSIIYAHANILGTASTVIKGMLKQAKRHGKWHTISIRGVPHDAVRVFIRFLYSSCYEKEEMNefIMHLL 137
Cdd:cd18248    23 DVTLkvkYQDPKEEFMAHKVVLASSSPYFKAMFTSGLRECGMEVVPIEGVHPCVMSRLIEFAYTASISVGEKC--VLHVL 100

                          90       100
                  ....*....|....*....|...
gi 1901201836 138 LLSHAYVVPQLKRVCEWHLEHGL 160
Cdd:cd18248   101 PGAVMYQMDSVVKACCDFLEQQL 123
BTB1_POZ_RhoBTB cd18299
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 50-156 5.52e-03

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. In vertebrates, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349608 [Multi-domain]  Cd Length: 103  Bit Score: 36.04  E-value: 5.52e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1901201836  50 WDRLFNDGYKADVVIYTDNGSIIYAHANILGTASTVIK---GMLKqakrhgkwhTISIRG-VPHDAVRVFIRFLYSSCYE 125
Cdd:cd18299     3 LRNLLHSPSCADVVFILQGGVRIFAHRIVLAAASSVFAdlfLMMT---------VVTLDSdITPEAFRRVLEFLYTGVLD 73

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1901201836 126 KEEMNefIMHLLLLSHAYVVPQLKRVCEWHL 156
Cdd:cd18299    74 ENEDD--LKELKDAAELLELFDLVMMCTNVL 102
BTB_POZ_ARIA_plant cd18352
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 55-166 6.42e-03

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant ARM repeat protein interacting with ABF2 (ARIA) and similar proteins; ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2, a transcription factor which controls ABA-dependent gene expression via the G-box-type ABA-responsive elements. ARIA is a novel abscisic acid signaling component. It negatively regulates seed germination and young seedling growth. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349661 [Multi-domain]  Cd Length: 116  Bit Score: 36.30  E-value: 6.42e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1901201836  55 NDGYKADVVIYTDnGSIIYAHANILGTASTVIKGMLKQAKRHGKWHTISIRGVPHDAVRVFIRFLYSScyEKEEMNEFIM 134
Cdd:cd18352     9 NNATLSDVTFLVE-GRRFYAHRIALLASSDAFRAMFDGGYREKEARDIEIPNIRWEVFELMMRFIYTG--SVDITNDIAK 85

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1901201836 135 HLLLLSHAYVVPQLKRVCEWHLEHGlLTTENV 166
Cdd:cd18352    86 DLLRAADQYLLEGLKRLCEYTIAQD-LTLENI 116
BTB2_POZ_RhoBTB cd18300
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 53-156 8.28e-03

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, a tandem of 2 BTB domains, and a conserved C-terminal region. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349609 [Multi-domain]  Cd Length: 108  Bit Score: 35.68  E-value: 8.28e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1901201836  53 LFNDGYKADVVIYTDNGSiIYAHANILGTASTVIKGMLKQAKRHGKWHTISIRGVPHDAVRVFIRFLYS-SCYEKEEMNe 131
Cdd:cd18300     3 FLNKGLFSDVTFIVEDGT-IPAHKALLVARCDVMAAMFGGNFRESSAKEVELPGVSKETFLALLEYLYTdQAPILEDGD- 80

                          90       100
                  ....*....|....*....|....*
gi 1901201836 132 fIMHLLLLSHAYVVPQLKRVCEWHL 156
Cdd:cd18300    81 -CVGLIVLANRLCLPRLVALCEQYI 104
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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