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Conserved domains on  [gi|1991450769|emb|CAE6912728|]
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KIFC3 [Symbiodinium sp. CCMP2592]

Protein Classification

glycosyltransferase family 47 protein( domain architecture ID 140283)

glycosyltransferase family 47 protein, also called exostosin (EXT) family protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
RXYLT1-like super family cl20239
ribitol-5-phosphate xylosyltransferase 1, and related proteins; Ribitol-5-phosphate ...
158-439 6.78e-14

ribitol-5-phosphate xylosyltransferase 1, and related proteins; Ribitol-5-phosphate xylosyltransferase 1 (RXYLT1, also known as transmembrane protein 5, TMEM5) is a transmembrane protein which acts as a UDP-d-xylose:ribitol-5-phosphate beta1,4-xylosyltransferase in the biosynthetic pathway of O-mannosyl glycan. RXYLT1 catalyzes the transfer of UDP-D-xylose to ribitol 5-phosphate (Rbo5P) to form the Xylbeta1-4Rbo5P linkage on O-mannosyl glycan. O-mannosyl glycan is present in a number of glycoproteins, including alpha-dystroglycan. The TMEM5 gene has been associated with alpha-dystroglycanopathies, a diverse group of neuromuscular disorders caused by aberrant O-mannosylation of alpha-dystroglycan.


The actual alignment was detected with superfamily member pfam03016:

Pssm-ID: 473306  Cd Length: 290  Bit Score: 72.46  E-value: 6.78e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1991450769 158 EGEWSAWRQHAGEVTLLQKFLTAPAEVLVESFEEADLIVVPGLFQFASSGHMFQKLVRRCPRDFAEELEHLN-FMDPTQ- 235
Cdd:pfam03016  22 QPCRSLTGWYSAEQFLLESILHSRIECRTSDPDEADCFFVPFYASLDASRHLLNSALTDLFRELLDWLKSQYpYWNRSGg 101
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1991450769 236 TPHLFVFADHMNNLRENDPGglgcyitRHPDNIFVSLGTELSSPNH--------ITMPPVVTEAELQpWSSTAETTRETF 307
Cdd:pfam03016 102 RDHFIVSGHPAWSFRRTAPD-------VDWGRAMLLNLTVLFSEDQfrpgkdvaLPYPTPFHPDIGQ-WQDISPSNRRKT 173
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1991450769 308 LLY---TENLDCCHPVRRHLYDVLVSDIGQAFCNSRcivetisqaqsAAKAGGVDQTRAMQHSVFCPLGPGEVPHRHKFY 384
Cdd:pfam03016 174 LLFfagNRRRGYSGKIRPLLLEECKGNPDADICGGL-----------QCTPGRDKYMELLRSSRFCLQPPGDTPTSPRLF 242
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1991450769 385 KAILAGCIPVLFdfpSYfpkqrswwkefgspfQLSLPFFEVIPYTDFVVTVPCTD 439
Cdd:pfam03016 243 DALLAGCIPVII---SD---------------GWELPFADVIDWRKFSVFVPEND 279
 
Name Accession Description Interval E-value
Exostosin pfam03016
Exostosin family; The EXT family is a family of tumour suppressor genes. Mutations of EXT1 on ...
158-439 6.78e-14

Exostosin family; The EXT family is a family of tumour suppressor genes. Mutations of EXT1 on 8q24.1, EXT2 on 11p11-13, and EXT3 on 19p have been associated with the autosomal dominant disorder known as hereditary multiple exostoses (HME). This is the most common known skeletal dysplasia. The chromosomal locations of other EXT genes suggest association with other forms of neoplasia. EXT1 and EXT2 have both been shown to encode a heparan sulphate polymerase with both D-glucuronyl (GlcA) and N-acetyl-D-glucosaminoglycan (GlcNAC) transferase activities. The nature of the defect in heparan sulphate biosynthesis in HME is unclear.


Pssm-ID: 397245  Cd Length: 290  Bit Score: 72.46  E-value: 6.78e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1991450769 158 EGEWSAWRQHAGEVTLLQKFLTAPAEVLVESFEEADLIVVPGLFQFASSGHMFQKLVRRCPRDFAEELEHLN-FMDPTQ- 235
Cdd:pfam03016  22 QPCRSLTGWYSAEQFLLESILHSRIECRTSDPDEADCFFVPFYASLDASRHLLNSALTDLFRELLDWLKSQYpYWNRSGg 101
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1991450769 236 TPHLFVFADHMNNLRENDPGglgcyitRHPDNIFVSLGTELSSPNH--------ITMPPVVTEAELQpWSSTAETTRETF 307
Cdd:pfam03016 102 RDHFIVSGHPAWSFRRTAPD-------VDWGRAMLLNLTVLFSEDQfrpgkdvaLPYPTPFHPDIGQ-WQDISPSNRRKT 173
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1991450769 308 LLY---TENLDCCHPVRRHLYDVLVSDIGQAFCNSRcivetisqaqsAAKAGGVDQTRAMQHSVFCPLGPGEVPHRHKFY 384
Cdd:pfam03016 174 LLFfagNRRRGYSGKIRPLLLEECKGNPDADICGGL-----------QCTPGRDKYMELLRSSRFCLQPPGDTPTSPRLF 242
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1991450769 385 KAILAGCIPVLFdfpSYfpkqrswwkefgspfQLSLPFFEVIPYTDFVVTVPCTD 439
Cdd:pfam03016 243 DALLAGCIPVII---SD---------------GWELPFADVIDWRKFSVFVPEND 279
 
Name Accession Description Interval E-value
Exostosin pfam03016
Exostosin family; The EXT family is a family of tumour suppressor genes. Mutations of EXT1 on ...
158-439 6.78e-14

Exostosin family; The EXT family is a family of tumour suppressor genes. Mutations of EXT1 on 8q24.1, EXT2 on 11p11-13, and EXT3 on 19p have been associated with the autosomal dominant disorder known as hereditary multiple exostoses (HME). This is the most common known skeletal dysplasia. The chromosomal locations of other EXT genes suggest association with other forms of neoplasia. EXT1 and EXT2 have both been shown to encode a heparan sulphate polymerase with both D-glucuronyl (GlcA) and N-acetyl-D-glucosaminoglycan (GlcNAC) transferase activities. The nature of the defect in heparan sulphate biosynthesis in HME is unclear.


Pssm-ID: 397245  Cd Length: 290  Bit Score: 72.46  E-value: 6.78e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1991450769 158 EGEWSAWRQHAGEVTLLQKFLTAPAEVLVESFEEADLIVVPGLFQFASSGHMFQKLVRRCPRDFAEELEHLN-FMDPTQ- 235
Cdd:pfam03016  22 QPCRSLTGWYSAEQFLLESILHSRIECRTSDPDEADCFFVPFYASLDASRHLLNSALTDLFRELLDWLKSQYpYWNRSGg 101
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1991450769 236 TPHLFVFADHMNNLRENDPGglgcyitRHPDNIFVSLGTELSSPNH--------ITMPPVVTEAELQpWSSTAETTRETF 307
Cdd:pfam03016 102 RDHFIVSGHPAWSFRRTAPD-------VDWGRAMLLNLTVLFSEDQfrpgkdvaLPYPTPFHPDIGQ-WQDISPSNRRKT 173
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1991450769 308 LLY---TENLDCCHPVRRHLYDVLVSDIGQAFCNSRcivetisqaqsAAKAGGVDQTRAMQHSVFCPLGPGEVPHRHKFY 384
Cdd:pfam03016 174 LLFfagNRRRGYSGKIRPLLLEECKGNPDADICGGL-----------QCTPGRDKYMELLRSSRFCLQPPGDTPTSPRLF 242
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1991450769 385 KAILAGCIPVLFdfpSYfpkqrswwkefgspfQLSLPFFEVIPYTDFVVTVPCTD 439
Cdd:pfam03016 243 DALLAGCIPVII---SD---------------GWELPFADVIDWRKFSVFVPEND 279
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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