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Conserved domains on  [gi|40035941|emb|CAE91255|]
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unnamed protein product [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
129-383 8.27e-09

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.01  E-value: 8.27e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40035941 129 LHQRIHTSEKPYKCDKCDKFFRRLSTLILHLRIHNGEKLYRCNKCekVCNRHSSLIQHQKVHTKKK-KLFECKECGKMFS 207
Cdd:COG5048 188 ISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTN--SQLSPKSLLSQSPSSLSSSdSSSSASESPRSSL 265

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40035941 208 GTANLKIHQNIHSEE-------KPFKCNKCSKVFGRQSFLIEHQR--IHTGE--KPYQCEE--CGKAFSHRISLTRHKRI 274
Cdd:COG5048 266 PTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILL 345

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40035941 275 HTEDRPYEC--DQCGKAFSQSTH-----LAQHERIHTGEKPYTC--KTCGKAFSQRTSLILHERSHTGEKPYECN--ECG 343
Cdd:COG5048 346 HTSISPAKEklLNSSSKFSPLLNneppqSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCS 425

                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 40035941 344 KAFSSGSDLIRHQRSHSSEKPYECSKCGKaYGRSSSLIRH 383
Cdd:COG5048 426 KSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNH 464
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
129-383 8.27e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.01  E-value: 8.27e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40035941 129 LHQRIHTSEKPYKCDKCDKFFRRLSTLILHLRIHNGEKLYRCNKCekVCNRHSSLIQHQKVHTKKK-KLFECKECGKMFS 207
Cdd:COG5048 188 ISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTN--SQLSPKSLLSQSPSSLSSSdSSSSASESPRSSL 265

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40035941 208 GTANLKIHQNIHSEE-------KPFKCNKCSKVFGRQSFLIEHQR--IHTGE--KPYQCEE--CGKAFSHRISLTRHKRI 274
Cdd:COG5048 266 PTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILL 345

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40035941 275 HTEDRPYEC--DQCGKAFSQSTH-----LAQHERIHTGEKPYTC--KTCGKAFSQRTSLILHERSHTGEKPYECN--ECG 343
Cdd:COG5048 346 HTSISPAKEklLNSSSKFSPLLNneppqSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCS 425

                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 40035941 344 KAFSSGSDLIRHQRSHSSEKPYECSKCGKaYGRSSSLIRH 383
Cdd:COG5048 426 KSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
295-320 1.04e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.04e-03
                          10        20
                  ....*....|....*....|....*.
gi 40035941   295 HLAQHERIHTGEKPYTCKTCGKAFSQ 320
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 170-221 1.70e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 37.15  E-value: 1.70e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 40035941 170 CNKCEKVCNRHSSLIQHQKVHTkkkklFECKECGKMFSGTANLKIH-QNIHSE 221
Cdd:cd20908   4 CYYCDREFDDEKILIQHQKAKH-----FKCHICHKKLYTAGGLAVHcLQVHKE 51
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
129-383 8.27e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.01  E-value: 8.27e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40035941 129 LHQRIHTSEKPYKCDKCDKFFRRLSTLILHLRIHNGEKLYRCNKCekVCNRHSSLIQHQKVHTKKK-KLFECKECGKMFS 207
Cdd:COG5048 188 ISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTN--SQLSPKSLLSQSPSSLSSSdSSSSASESPRSSL 265

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40035941 208 GTANLKIHQNIHSEE-------KPFKCNKCSKVFGRQSFLIEHQR--IHTGE--KPYQCEE--CGKAFSHRISLTRHKRI 274
Cdd:COG5048 266 PTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILL 345

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40035941 275 HTEDRPYEC--DQCGKAFSQSTH-----LAQHERIHTGEKPYTC--KTCGKAFSQRTSLILHERSHTGEKPYECN--ECG 343
Cdd:COG5048 346 HTSISPAKEklLNSSSKFSPLLNneppqSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCS 425

                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 40035941 344 KAFSSGSDLIRHQRSHSSEKPYECSKCGKaYGRSSSLIRH 383
Cdd:COG5048 426 KSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
110-388 8.42e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.85  E-value: 8.42e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40035941 110 NPFKCRKCGKLFNRISPLMLHQRIHTSEKPYKC--DKCDKFFRRLSTLILHLRIHNGEKLYRCNKCEKVC---------- 177
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSnskassssls 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40035941 178 ------NRHSSLIQHQKVHTKKKKL---------FECKECGKMFSGTANLKIHQNIHSEEKPFkcNKCSKVFGRQSFLIE 242
Cdd:COG5048 112 ssssnsNDNNLLSSHSLPPSSRDPQlpdllsisnLRNNPLPGNNSSSVNTPQSNSLHPPLPAN--SLSKDPSSNLSLLIS 189

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40035941 243 HQRIHTGEKPYQCEECGKAFSHRISLTRHKRIHTEDrPYECDQCGKAFSQSTHLAQHERIHTGEKPYTCKTC-----GKA 317
Cdd:COG5048 190 SNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSS-SLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESprsslPTA 268

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 40035941 318 FSQRTSLILH-ERSHTG-EKPYECNECGKAFSSGSDLIRHQRS--HSSE--KPYEC--SKCGKAYGRSSSLIRHQNTHS 388
Cdd:COG5048 269 SSQSSSPNESdSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHT 347
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
215-294 8.73e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.30  E-value: 8.73e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40035941 215 HQNIHSEEKPFKCNKCSKVFGRQSFLIEHQRIHTGEKPYQC--EECGKAFSHRISLTRHKRIHTEDRPYECDQCGKAFSQ 292
Cdd:COG5048  24 LKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNS 103


                ..
gi 40035941 293 ST 294
Cdd:COG5048 104 KA 105
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
81-294 1.96e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.15  E-value: 1.96e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40035941  81 HKRIHAGEKIPENAKALSQSLQQRSHHLENPFKCRKCGKLFNRISPLMLHQRIHTS-EKPYKCDKCDKFFRRLSTLILHL 159
Cdd:COG5048 230 TTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHL 309

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40035941 160 R--IHNGEKLYRC----NKCEKVCNRHSSLIQHQKVHTKKK--KLFECKECGKMFSGTANLKI----HQNIHSEEKPFKC 227
Cdd:COG5048 310 RsvNHSGESLKPFscpySLCGKLFSRNDALKRHILLHTSISpaKEKLLNSSSKFSPLLNNEPPqslqQYKDLKNDKKSET 389

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 40035941 228 --NKCSKVFGRQSFLIEHQRIHTGEKPYQCE--ECGKAFSHRISLTRHKRIHTEDRPYECDQCGKAFSQST 294
Cdd:COG5048 390 lsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLD 460
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
278-368 5.79e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.99  E-value: 5.79e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40035941 278 DRPYECDQCGKAFSQSTHLAQHERIHTGEKPYTC--KTCGKAFSQRTSLILHERSHTGEKPYECN--ECGKAFSSGSDLI 353
Cdd:COG5048  31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSksLPLSNSKASSSSL 110

                        90
                ....*....|....*
gi 40035941 354 RHQRSHSSEKPYECS 368
Cdd:COG5048 111 SSSSSNSNDNNLLSS 125
zf-H2C2_2 pfam13465
Zinc-finger double domain;
295-320 1.04e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.04e-03
                          10        20
                  ....*....|....*....|....*.
gi 40035941   295 HLAQHERIHTGEKPYTCKTCGKAFSQ 320
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 170-221 1.70e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 37.15  E-value: 1.70e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 40035941 170 CNKCEKVCNRHSSLIQHQKVHTkkkklFECKECGKMFSGTANLKIH-QNIHSE 221
Cdd:cd20908   4 CYYCDREFDDEKILIQHQKAKH-----FKCHICHKKLYTAGGLAVHcLQVHKE 51
zf-H2C2_2 pfam13465
Zinc-finger double domain;
240-264 1.88e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 1.88e-03
                          10        20
                  ....*....|....*....|....*
gi 40035941   240 LIEHQRIHTGEKPYQCEECGKAFSH 264
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
267-292 2.79e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 2.79e-03
                          10        20
                  ....*....|....*....|....*.
gi 40035941   267 SLTRHKRIHTEDRPYECDQCGKAFSQ 292
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
323-348 5.23e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 5.23e-03
                          10        20
                  ....*....|....*....|....*.
gi 40035941   323 SLILHERSHTGEKPYECNECGKAFSS 348
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
335-391 5.63e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 38.52  E-value: 5.63e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 40035941 335 KPYECNECGKAFSSGSDLIRHQRSHSSEKPYECSK--CGKAYGRSSSLIRHQNTHSEEK 391
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNP 90
zf-H2C2_2 pfam13465
Zinc-finger double domain;
127-151 7.60e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 7.60e-03
                          10        20
                  ....*....|....*....|....*
gi 40035941   127 LMLHQRIHTSEKPYKCDKCDKFFRR 151
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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