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Conserved domains on  [gi|53130642|emb|CAG31650|]
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hypothetical protein RCJMB04_9c4 [Gallus gallus]

Protein Classification

SANT/Myb-like DNA-binding domain-containing protein( domain architecture ID 10621739)

SANT (SWI3, ADA2, N-CoR and TFIIIB)/Myb-like DNA-binding domain-containing protein may bind DNA and function as a transcription factor

CATH:  1.20.58.1880
Gene Ontology:  GO:0006355|GO:0003677|GO:0003700
PubMed:  8882580
SCOP:  4000317

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DMTF1_N pfam20588
Cyclin-D-binding Myb-like transcription factor 1 N-terminal; This domain is found at the ...
 79-157 1.27e-22

Cyclin-D-binding Myb-like transcription factor 1 N-terminal; This domain is found at the N-terminal of Cyclin-D-binding Myb-like transcription factor 1 (DMTF1), which is rich in acidic residues, adjacent pfam00249. DMTF1 is a tumour suppressor that interacts with and activates CDKN2A/ARF in response to Ras-Raf signalling, thus inducing p53-dependent cell cycle arrest.


:

Pssm-ID: 466737  Cd Length: 72  Bit Score: 89.79  E-value: 1.27e-22
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 53130642    79 ENDQSFEVTMTataEVAEDEINEGTVTQIQILQNEQLDEIspmgNEEVSAVSQAWFTTKEDKDSLTNKGHKWKQGMWSK 157
Cdd:pfam20588   1 SPDKSFEVTMT---EVKDDELSERTKRQISKLENEKINLV----IYEVSSVSQAIFTYKEDKDTLINKGHKWKQGIWYK 72
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 273-328 1.48e-10

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


:

Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 55.97  E-value: 1.48e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 53130642   273 GKWTEEEEKRLAEVVHELtstepgdivtqGVSWAAVAERVGTRSEKQCRSKWLNYL 328
Cdd:pfam00249   2 GPWTPEEDELLLEAVEKL-----------GNRWKKIAKLLPGRTDNQCKNRWQNYL 46
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 227-283 5.95e-09

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


:

Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 51.54  E-value: 5.95e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 53130642   227 TPEEIERLKELRIKHGNDWATIGAALG-RSASSVKDR-CRLMKDTCNTGKWTEEEEKRL 283
Cdd:pfam13921   2 TEEEDEKLLKLVEKYGNDWKQIAKELGrRTPKQCFDRwRRKLNPKISRGPWSKEEDQRL 60
 
Name Accession Description Interval E-value
DMTF1_N pfam20588
Cyclin-D-binding Myb-like transcription factor 1 N-terminal; This domain is found at the ...
 79-157 1.27e-22

Cyclin-D-binding Myb-like transcription factor 1 N-terminal; This domain is found at the N-terminal of Cyclin-D-binding Myb-like transcription factor 1 (DMTF1), which is rich in acidic residues, adjacent pfam00249. DMTF1 is a tumour suppressor that interacts with and activates CDKN2A/ARF in response to Ras-Raf signalling, thus inducing p53-dependent cell cycle arrest.


Pssm-ID: 466737  Cd Length: 72  Bit Score: 89.79  E-value: 1.27e-22
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 53130642    79 ENDQSFEVTMTataEVAEDEINEGTVTQIQILQNEQLDEIspmgNEEVSAVSQAWFTTKEDKDSLTNKGHKWKQGMWSK 157
Cdd:pfam20588   1 SPDKSFEVTMT---EVKDDELSERTKRQISKLENEKINLV----IYEVSSVSQAIFTYKEDKDTLINKGHKWKQGIWYK 72
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 273-328 1.48e-10

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 55.97  E-value: 1.48e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 53130642   273 GKWTEEEEKRLAEVVHELtstepgdivtqGVSWAAVAERVGTRSEKQCRSKWLNYL 328
Cdd:pfam00249   2 GPWTPEEDELLLEAVEKL-----------GNRWKKIAKLLPGRTDNQCKNRWQNYL 46
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 227-283 5.95e-09

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 51.54  E-value: 5.95e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 53130642   227 TPEEIERLKELRIKHGNDWATIGAALG-RSASSVKDR-CRLMKDTCNTGKWTEEEEKRL 283
Cdd:pfam13921   2 TEEEDEKLLKLVEKYGNDWKQIAKELGrRTPKQCFDRwRRKLNPKISRGPWSKEEDQRL 60
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 274-328 1.13e-08

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 50.27  E-value: 1.13e-08
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 53130642 274 KWTEEEEKRLAEVVHELtstepgdivtQGVSWAAVAERVGTRSEKQCRSKWLNYL 328
Cdd:cd00167   1 PWTEEEDELLLEAVKKY----------GKNNWEKIAKELPGRTPKQCRERWRNLL 45
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
273-329 1.92e-08

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 49.91  E-value: 1.92e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 53130642    273 GKWTEEEEKRLAEVVHELtstepGDIvtqgvSWAAVAERVGTRSEKQCRSKWLNYLN 329
Cdd:smart00717   2 GEWTEEEDELLIELVKKY-----GKN-----NWEKIAKELPGRTAEQCRERWRNLLK 48
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
224-269 2.21e-05

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 41.44  E-value: 2.21e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 53130642    224 GKYTPEEIERLKELRIKHG-NDWATIGAALG-RSASSVKDRCRLMKDT 269
Cdd:smart00717   2 GEWTEEEDELLIELVKKYGkNNWEKIAKELPgRTAEQCRERWRNLLKP 49
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 225-267 2.30e-05

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 41.02  E-value: 2.30e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 53130642 225 KYTPEEIERLKELRIKHG-NDWATIGAALG-RSASSVKDRCRLMK 267
Cdd:cd00167   1 PWTEEEDELLLEAVKKYGkNNWEKIAKELPgRTPKQCRERWRNLL 45
REB1 COG5147
Myb superfamily proteins, including transcription factors and mRNA splicing factors ...
 211-323 1.45e-04

Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning];


Pssm-ID: 227476 [Multi-domain]  Cd Length: 512  Bit Score: 43.62  E-value: 1.45e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53130642 211 RRVLRMYDDRnhvGKYTPEEIERLKELRIKHGNDWATIGAALGRSASSVKDRCR---LMKDTCNTGKWTEEEEKRLAEVV 287
Cdd:COG5147 282 RRKYNIFEQR---GKWTKEEEQELAKLVVEHGGSWTEIGKLLGRMPNDCRDRWRdyvKCGDTLKRNRWSIEEEELLDKVV 358

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 53130642 288 HELTStepGDIVTQGVSWAAVAERVGTRSEKQCRSK 323
Cdd:COG5147 359 NEMRL---EAQQSSRILWLLIAQNIRNRLQHHCRDK 391
 
Name Accession Description Interval E-value
DMTF1_N pfam20588
Cyclin-D-binding Myb-like transcription factor 1 N-terminal; This domain is found at the ...
 79-157 1.27e-22

Cyclin-D-binding Myb-like transcription factor 1 N-terminal; This domain is found at the N-terminal of Cyclin-D-binding Myb-like transcription factor 1 (DMTF1), which is rich in acidic residues, adjacent pfam00249. DMTF1 is a tumour suppressor that interacts with and activates CDKN2A/ARF in response to Ras-Raf signalling, thus inducing p53-dependent cell cycle arrest.


Pssm-ID: 466737  Cd Length: 72  Bit Score: 89.79  E-value: 1.27e-22
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 53130642    79 ENDQSFEVTMTataEVAEDEINEGTVTQIQILQNEQLDEIspmgNEEVSAVSQAWFTTKEDKDSLTNKGHKWKQGMWSK 157
Cdd:pfam20588   1 SPDKSFEVTMT---EVKDDELSERTKRQISKLENEKINLV----IYEVSSVSQAIFTYKEDKDTLINKGHKWKQGIWYK 72
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 273-328 1.48e-10

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 55.97  E-value: 1.48e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 53130642   273 GKWTEEEEKRLAEVVHELtstepgdivtqGVSWAAVAERVGTRSEKQCRSKWLNYL 328
Cdd:pfam00249   2 GPWTPEEDELLLEAVEKL-----------GNRWKKIAKLLPGRTDNQCKNRWQNYL 46
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 227-283 5.95e-09

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 51.54  E-value: 5.95e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 53130642   227 TPEEIERLKELRIKHGNDWATIGAALG-RSASSVKDR-CRLMKDTCNTGKWTEEEEKRL 283
Cdd:pfam13921   2 TEEEDEKLLKLVEKYGNDWKQIAKELGrRTPKQCFDRwRRKLNPKISRGPWSKEEDQRL 60
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 274-328 1.13e-08

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 50.27  E-value: 1.13e-08
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 53130642 274 KWTEEEEKRLAEVVHELtstepgdivtQGVSWAAVAERVGTRSEKQCRSKWLNYL 328
Cdd:cd00167   1 PWTEEEDELLLEAVKKY----------GKNNWEKIAKELPGRTPKQCRERWRNLL 45
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
273-329 1.92e-08

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 49.91  E-value: 1.92e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 53130642    273 GKWTEEEEKRLAEVVHELtstepGDIvtqgvSWAAVAERVGTRSEKQCRSKWLNYLN 329
Cdd:smart00717   2 GEWTEEEDELLIELVKKY-----GKN-----NWEKIAKELPGRTAEQCRERWRNLLK 48
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 224-267 1.74e-07

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 47.11  E-value: 1.74e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 53130642   224 GKYTPEEIERLKELRIKHGNDWATIGAAL-GRSASSVKDRCRLMK 267
Cdd:pfam00249   2 GPWTPEEDELLLEAVEKLGNRWKKIAKLLpGRTDNQCKNRWQNYL 46
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 275-346 1.70e-06

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 44.61  E-value: 1.70e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 53130642   275 WTEEEEKRLAEVVHELTSTepgdivtqgvsWAAVAERVGTRSEKQCRSKWLNYLNWKQSGGtEWTKEDEINL 346
Cdd:pfam13921   1 WTEEEDEKLLKLVEKYGND-----------WKQIAKELGRRTPKQCFDRWRRKLNPKISRG-PWSKEEDQRL 60
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
224-269 2.21e-05

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 41.44  E-value: 2.21e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 53130642    224 GKYTPEEIERLKELRIKHG-NDWATIGAALG-RSASSVKDRCRLMKDT 269
Cdd:smart00717   2 GEWTEEEDELLIELVKKYGkNNWEKIAKELPgRTAEQCRERWRNLLKP 49
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 225-267 2.30e-05

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 41.02  E-value: 2.30e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 53130642 225 KYTPEEIERLKELRIKHG-NDWATIGAALG-RSASSVKDRCRLMK 267
Cdd:cd00167   1 PWTEEEDELLLEAVKKYGkNNWEKIAKELPgRTPKQCRERWRNLL 45
REB1 COG5147
Myb superfamily proteins, including transcription factors and mRNA splicing factors ...
 211-323 1.45e-04

Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning];


Pssm-ID: 227476 [Multi-domain]  Cd Length: 512  Bit Score: 43.62  E-value: 1.45e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53130642 211 RRVLRMYDDRnhvGKYTPEEIERLKELRIKHGNDWATIGAALGRSASSVKDRCR---LMKDTCNTGKWTEEEEKRLAEVV 287
Cdd:COG5147 282 RRKYNIFEQR---GKWTKEEEQELAKLVVEHGGSWTEIGKLLGRMPNDCRDRWRdyvKCGDTLKRNRWSIEEEELLDKVV 358

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 53130642 288 HELTStepGDIVTQGVSWAAVAERVGTRSEKQCRSK 323
Cdd:COG5147 359 NEMRL---EAQQSSRILWLLIAQNIRNRLQHHCRDK 391
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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