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Conserved domains on  [gi|2031953371|emb|CAG4718689|]
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unnamed protein product [Naegleria fowleri]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
19-317 2.86e-35

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 132.34  E-value: 2.86e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2031953371  19 LHQTAPIKTFSsEHQDMIHDAQ--ADyyGKRLATCSSDCTIRIFDLAPGgteqqepKLLDVLTGHEGPVWQVSWAHPqfG 96
Cdd:COG2319   149 LATGKLLRTLT-GHSGAVTSVAfsPD--GKLLASGSDDGTVRLWDLATG-------KLLRTLTGHTGAVRSVAFSPD--G 216

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2031953371  97 SILASCSYDHKVIIWkeNQQTHKWAKVFDYRlDSSVNSISWAPheHGLHLASASSDCQITIFSydeqSNNWRVSNIRDAH 176
Cdd:COG2319   217 KLLASGSADGTVRLW--DLATGKLLRTLTGH-SGSVRSVAFSP--DGRLLASGSADGTVRLWD----LATGELLRTLTGH 287

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2031953371 177 KIGCNSVCWAPAShtgalvqqpsqdqpesskfvKRLVSGGSDNLVKIWEYNesiNQWKDTTLEGHTDWVRDVSWAPNiGl 256
Cdd:COG2319   288 SGGVNSVAFSPDG--------------------KLLASGSDDGTVRLWDLA---TGKLLRTLTGHTGAVRSVAFSPD-G- 342

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2031953371 257 pyETIASCSQDKTVIIWtrDQNSNQWSKQVLTFDHVVWRVSWSLTGNILAVSTADNEVTLW 317
Cdd:COG2319   343 --KTLASGSDDGTVRLW--DLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLW 399
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
19-317 2.86e-35

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 132.34  E-value: 2.86e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2031953371  19 LHQTAPIKTFSsEHQDMIHDAQ--ADyyGKRLATCSSDCTIRIFDLAPGgteqqepKLLDVLTGHEGPVWQVSWAHPqfG 96
Cdd:COG2319   149 LATGKLLRTLT-GHSGAVTSVAfsPD--GKLLASGSDDGTVRLWDLATG-------KLLRTLTGHTGAVRSVAFSPD--G 216

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2031953371  97 SILASCSYDHKVIIWkeNQQTHKWAKVFDYRlDSSVNSISWAPheHGLHLASASSDCQITIFSydeqSNNWRVSNIRDAH 176
Cdd:COG2319   217 KLLASGSADGTVRLW--DLATGKLLRTLTGH-SGSVRSVAFSP--DGRLLASGSADGTVRLWD----LATGELLRTLTGH 287

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2031953371 177 KIGCNSVCWAPAShtgalvqqpsqdqpesskfvKRLVSGGSDNLVKIWEYNesiNQWKDTTLEGHTDWVRDVSWAPNiGl 256
Cdd:COG2319   288 SGGVNSVAFSPDG--------------------KLLASGSDDGTVRLWDLA---TGKLLRTLTGHTGAVRSVAFSPD-G- 342

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2031953371 257 pyETIASCSQDKTVIIWtrDQNSNQWSKQVLTFDHVVWRVSWSLTGNILAVSTADNEVTLW 317
Cdd:COG2319   343 --KTLASGSDDGTVRLW--DLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLW 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 32-318 2.19e-28

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 111.27  E-value: 2.19e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2031953371  32 HQDMIHDAQADYYGKRLATCSSDCTIRIFDLapggteqQEPKLLDVLTGHEGPVWQVSWaHPQfGSILASCSYDHKVIIW 111
Cdd:cd00200    50 HTGPVRDVAASADGTYLASGSSDKTIRLWDL-------ETGECVRTLTGHTSYVSSVAF-SPD-GRILSSSSRDKTIKVW 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2031953371 112 KENQQTHKwaKVFDYRLDSsVNSISWAPHehGLHLASASSDCQITIFSydeqSNNWRVSNIRDAHKIGCNSVCWAPASht 191
Cdd:cd00200   121 DVETGKCL--TTLRGHTDW-VNSVAFSPD--GTFVASSSQDGTIKLWD----LRTGKCVATLTGHTGEVNSVAFSPDG-- 189

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2031953371 192 galvqqpsqdqpesskfvKRLVSGGSDNLVKIWEYNEsinQWKDTTLEGHTDWVRDVSWAPNIGLpyetIASCSQDKTVI 271
Cdd:cd00200   190 ------------------EKLLSSSSDGTIKLWDLST---GKCLGTLRGHENGVNSVAFSPDGYL----LASGSEDGTIR 244

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 2031953371 272 IWtrdqNSNQWS-KQVLT-FDHVVWRVSWSLTGNILAVSTADNEVTLWK 318
Cdd:cd00200   245 VW----DLRTGEcVQTLSgHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 73-112 5.93e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.60  E-value: 5.93e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 2031953371   73 KLLDVLTGHEGPVWQVSWAHpqFGSILASCSYDHKVIIWK 112
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSP--DGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
236-273 1.61e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.48  E-value: 1.61e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 2031953371 236 TTLEGHTDWVRDVSWAPNiglpYETIASCSQDKTVIIW 273
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPD----GKLLASGSDDGTVKVW 38
PTZ00420 PTZ00420
coronin; Provisional
 32-137 2.64e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 42.63  E-value: 2.64e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2031953371  32 HQDMIHDAQAD-YYGKRLATCSSDCTIRIFDLAPGGTEQQEPK-LLDVLTGHEGPVWQVSWaHPQFGSILASCSYDHKVI 109
Cdd:PTZ00420   73 HTSSILDLQFNpCFSEILASGSEDLTIRVWEIPHNDESVKEIKdPQCILKGHKKKISIIDW-NPMNYYIMCSSGFDSFVN 151

                          90       100
                  ....*....|....*....|....*....
gi 2031953371 110 IWK-ENQQthkwaKVFDYRLDSSVNSISW 137
Cdd:PTZ00420  152 IWDiENEK-----RAFQINMPKKLSSLKW 175
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
19-317 2.86e-35

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 132.34  E-value: 2.86e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2031953371  19 LHQTAPIKTFSsEHQDMIHDAQ--ADyyGKRLATCSSDCTIRIFDLAPGgteqqepKLLDVLTGHEGPVWQVSWAHPqfG 96
Cdd:COG2319   149 LATGKLLRTLT-GHSGAVTSVAfsPD--GKLLASGSDDGTVRLWDLATG-------KLLRTLTGHTGAVRSVAFSPD--G 216

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2031953371  97 SILASCSYDHKVIIWkeNQQTHKWAKVFDYRlDSSVNSISWAPheHGLHLASASSDCQITIFSydeqSNNWRVSNIRDAH 176
Cdd:COG2319   217 KLLASGSADGTVRLW--DLATGKLLRTLTGH-SGSVRSVAFSP--DGRLLASGSADGTVRLWD----LATGELLRTLTGH 287

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2031953371 177 KIGCNSVCWAPAShtgalvqqpsqdqpesskfvKRLVSGGSDNLVKIWEYNesiNQWKDTTLEGHTDWVRDVSWAPNiGl 256
Cdd:COG2319   288 SGGVNSVAFSPDG--------------------KLLASGSDDGTVRLWDLA---TGKLLRTLTGHTGAVRSVAFSPD-G- 342

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2031953371 257 pyETIASCSQDKTVIIWtrDQNSNQWSKQVLTFDHVVWRVSWSLTGNILAVSTADNEVTLW 317
Cdd:COG2319   343 --KTLASGSDDGTVRLW--DLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
45-317 1.12e-33

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 128.11  E-value: 1.12e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2031953371  45 GKRLATCSSDCTIRIFDLAPGgteqqepKLLDVLTGHEGPVWQVSWaHPQfGSILASCSYDHKVIIWkeNQQTHKWAKVF 124
Cdd:COG2319   132 GKTLASGSADGTVRLWDLATG-------KLLRTLTGHSGAVTSVAF-SPD-GKLLASGSDDGTVRLW--DLATGKLLRTL 200

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2031953371 125 DyRLDSSVNSISWAPheHGLHLASASSDCQITIFSydeqSNNWRVSNIRDAHKIGCNSVCWAPAShtgalvqqpsqdqpe 204
Cdd:COG2319   201 T-GHTGAVRSVAFSP--DGKLLASGSADGTVRLWD----LATGKLLRTLTGHSGSVRSVAFSPDG--------------- 258

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2031953371 205 sskfvKRLVSGGSDNLVKIWEYNESINQwkdTTLEGHTDWVRDVSWAPNiGlpyETIASCSQDKTVIIWtrDQNSNQWSK 284
Cdd:COG2319   259 -----RLLASGSADGTVRLWDLATGELL---RTLTGHSGGVNSVAFSPD-G---KLLASGSDDGTVRLW--DLATGKLLR 324

                         250       260       270
                  ....*....|....*....|....*....|...
gi 2031953371 285 QVLTFDHVVWRVSWSLTGNILAVSTADNEVTLW 317
Cdd:COG2319   325 TLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLW 357
WD40 COG2319
WD40 repeat [General function prediction only];
32-317 4.87e-32

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 123.48  E-value: 4.87e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2031953371  32 HQDMIHDAQADYYGKRLATCSSDCTIRIFDLAPGgteqqepKLLDVLTGHEGPVWQVSWaHPQfGSILASCSYDHKVIIW 111
Cdd:COG2319    77 HTAAVLSVAFSPDGRLLASASADGTVRLWDLATG-------LLLRTLTGHTGAVRSVAF-SPD-GKTLASGSADGTVRLW 147

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2031953371 112 keNQQTHKWAKVFDyRLDSSVNSISWAPheHGLHLASASSDCQITIFSYDeqsnNWRVSNIRDAHKIGCNSVCWAPASht 191
Cdd:COG2319   148 --DLATGKLLRTLT-GHSGAVTSVAFSP--DGKLLASGSDDGTVRLWDLA----TGKLLRTLTGHTGAVRSVAFSPDG-- 216

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2031953371 192 galvqqpsqdqpesskfvKRLVSGGSDNLVKIWEYNesiNQWKDTTLEGHTDWVRDVSWAPNiGlpyETIASCSQDKTVI 271
Cdd:COG2319   217 ------------------KLLASGSADGTVRLWDLA---TGKLLRTLTGHSGSVRSVAFSPD-G---RLLASGSADGTVR 271

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 2031953371 272 IWtrDQNSNQWSKQVLTFDHVVWRVSWSLTGNILAVSTADNEVTLW 317
Cdd:COG2319   272 LW--DLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLW 315
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 32-318 2.19e-28

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 111.27  E-value: 2.19e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2031953371  32 HQDMIHDAQADYYGKRLATCSSDCTIRIFDLapggteqQEPKLLDVLTGHEGPVWQVSWaHPQfGSILASCSYDHKVIIW 111
Cdd:cd00200    50 HTGPVRDVAASADGTYLASGSSDKTIRLWDL-------ETGECVRTLTGHTSYVSSVAF-SPD-GRILSSSSRDKTIKVW 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2031953371 112 KENQQTHKwaKVFDYRLDSsVNSISWAPHehGLHLASASSDCQITIFSydeqSNNWRVSNIRDAHKIGCNSVCWAPASht 191
Cdd:cd00200   121 DVETGKCL--TTLRGHTDW-VNSVAFSPD--GTFVASSSQDGTIKLWD----LRTGKCVATLTGHTGEVNSVAFSPDG-- 189

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2031953371 192 galvqqpsqdqpesskfvKRLVSGGSDNLVKIWEYNEsinQWKDTTLEGHTDWVRDVSWAPNIGLpyetIASCSQDKTVI 271
Cdd:cd00200   190 ------------------EKLLSSSSDGTIKLWDLST---GKCLGTLRGHENGVNSVAFSPDGYL----LASGSEDGTIR 244

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 2031953371 272 IWtrdqNSNQWS-KQVLT-FDHVVWRVSWSLTGNILAVSTADNEVTLWK 318
Cdd:cd00200   245 VW----DLRTGEcVQTLSgHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 32-317 1.25e-25

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 103.95  E-value: 1.25e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2031953371  32 HQDMIHDAQADYYGKRLATCSSDCTIRIFDLAPGgteqqepKLLDVLTGHEGPVWQVSWAHpqFGSILASCSYDHKVIIW 111
Cdd:cd00200     8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETG-------ELLRTLKGHTGPVRDVAASA--DGTYLASGSSDKTIRLW 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2031953371 112 --KENQQTHKWAKVFDYrldssVNSISWAPHEHglHLASASSDCQITIFsyDEQSNNwRVSNIRDaHKIGCNSVCWAPas 189
Cdd:cd00200    79 dlETGECVRTLTGHTSY-----VSSVAFSPDGR--ILSSSSRDKTIKVW--DVETGK-CLTTLRG-HTDWVNSVAFSP-- 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2031953371 190 htgalvqqpsqdqpeSSKFVkrlVSGGSDNLVKIWEynesINQWK-DTTLEGHTDWVRDVSWAPNiglpYETIASCSQDK 268
Cdd:cd00200   146 ---------------DGTFV---ASSSQDGTIKLWD----LRTGKcVATLTGHTGEVNSVAFSPD----GEKLLSSSSDG 199

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 2031953371 269 TVIIWtrDQNSNQWSKQVLTFDHVVWRVSWSLTGNILAVSTADNEVTLW 317
Cdd:cd00200   200 TIKLW--DLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVW 246
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 74-317 4.59e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 91.24  E-value: 4.59e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2031953371  74 LLDVLTGHEGPVWQVSWaHPQfGSILASCSYDHKVIIW-------KENQQTHKwakvfdyrldSSVNSISWAPheHGLHL 146
Cdd:cd00200     1 LRRTLKGHTGGVTCVAF-SPD-GKLLATGSGDGTIKVWdletgelLRTLKGHT----------GPVRDVAASA--DGTYL 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2031953371 147 ASASSDCQITIFSYdeqsNNWRVSNIRDAHKIGCNSVCWAPASHTgalvqqpsqdqpesskfvkrLVSGGSDNLVKIWEY 226
Cdd:cd00200    67 ASGSSDKTIRLWDL----ETGECVRTLTGHTSYVSSVAFSPDGRI--------------------LSSSSRDKTIKVWDV 122

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2031953371 227 NESINQwkdTTLEGHTDWVRDVSWAPNIGLpyetIASCSQDKTVIIWtrDQNSNQWSKQVLTFDHVVWRVSWSLTGNILA 306
Cdd:cd00200   123 ETGKCL---TTLRGHTDWVNSVAFSPDGTF----VASSSQDGTIKLW--DLRTGKCVATLTGHTGEVNSVAFSPDGEKLL 193

                         250
                  ....*....|.
gi 2031953371 307 VSTADNEVTLW 317
Cdd:cd00200   194 SSSSDGTIKLW 204
WD40 COG2319
WD40 repeat [General function prediction only];
56-317 2.06e-17

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 82.27  E-value: 2.06e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2031953371  56 TIRIFDLAPGGTEQQEPKLLDVLTGHEGPVWQVSWAHPqfGSILASCSYDHKVIIWKENQQTHKWAKVfdyRLDSSVNSI 135
Cdd:COG2319    10 AAASADLALALLAAALGALLLLLLGLAAAVASLAASPD--GARLAAGAGDLTLLLLDAAAGALLATLL---GHTAAVLSV 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2031953371 136 SWAPHehGLHLASASSDCQITIFsydeQSNNWRVSNIRDAHKIGCNSVCWAPAShtgalvqqpsqdqpesskfvKRLVSG 215
Cdd:COG2319    85 AFSPD--GRLLASASADGTVRLW----DLATGLLLRTLTGHTGAVRSVAFSPDG--------------------KTLASG 138

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2031953371 216 GSDNLVKIWEynesINQWKD-TTLEGHTDWVRDVSWAPNiGlpyETIASCSQDKTVIIWtrDQNSNQWSKQVLTFDHVVW 294
Cdd:COG2319   139 SADGTVRLWD----LATGKLlRTLTGHSGAVTSVAFSPD-G---KLLASGSDDGTVRLW--DLATGKLLRTLTGHTGAVR 208

                         250       260
                  ....*....|....*....|...
gi 2031953371 295 RVSWSLTGNILAVSTADNEVTLW 317
Cdd:COG2319   209 SVAFSPDGKLLASGSADGTVRLW 231
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 237-318 3.67e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 50.80  E-value: 3.67e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2031953371 237 TLEGHTDWVRDVSWAPNIGLpyetIASCSQDKTVIIWtrDQNSNQWSKQVLTFDHVVWRVSWSLTGNILAVSTADNEVTL 316
Cdd:cd00200     4 TLKGHTGGVTCVAFSPDGKL----LATGSGDGTIKVW--DLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRL 77


                  ..
gi 2031953371 317 WK 318
Cdd:cd00200    78 WD 79
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 73-112 5.93e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.60  E-value: 5.93e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 2031953371   73 KLLDVLTGHEGPVWQVSWAHpqFGSILASCSYDHKVIIWK 112
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSP--DGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 237-273 8.88e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.22  E-value: 8.88e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2031953371  237 TLEGHTDWVRDVSWAPNiglpYETIASCSQDKTVIIW 273
Cdd:smart00320   7 TLKGHTGPVTSVAFSPD----GKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
236-273 1.61e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.48  E-value: 1.61e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 2031953371 236 TTLEGHTDWVRDVSWAPNiglpYETIASCSQDKTVIIW 273
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPD----GKLLASGSDDGTVKVW 38
PTZ00420 PTZ00420
coronin; Provisional
 32-137 2.64e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 42.63  E-value: 2.64e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2031953371  32 HQDMIHDAQAD-YYGKRLATCSSDCTIRIFDLAPGGTEQQEPK-LLDVLTGHEGPVWQVSWaHPQFGSILASCSYDHKVI 109
Cdd:PTZ00420   73 HTSSILDLQFNpCFSEILASGSEDLTIRVWEIPHNDESVKEIKdPQCILKGHKKKISIIDW-NPMNYYIMCSSGFDSFVN 151

                          90       100
                  ....*....|....*....|....*....
gi 2031953371 110 IWK-ENQQthkwaKVFDYRLDSSVNSISW 137
Cdd:PTZ00420  152 IWDiENEK-----RAFQINMPKKLSSLKW 175
WD40 pfam00400
WD domain, G-beta repeat;
73-111 3.90e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.32  E-value: 3.90e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2031953371  73 KLLDVLTGHEGPVWQVSWahPQFGSILASCSYDHKVIIW 111
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAF--SPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 24-61 9.73e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 33.44  E-value: 9.73e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2031953371   24 PIKTFSSeHQDMIHDAQADYYGKRLATCSSDCTIRIFD 61
Cdd:smart00320   4 LLKTLKG-HTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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