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Conserved domains on  [gi|2031953382|emb|CAG4718695|]
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unnamed protein product [Naegleria fowleri]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 74-335 8.87e-39

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 140.55  E-value: 8.87e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2031953382  74 NQIISCSGDGSIKVFDTTNalggeGAPVMNFAEHSKEVYSVDYNTvNKDCFVSGSWDNTIKLWNLQAAGAGQtnassveT 153
Cdd:cd00200    64 TYLASGSSDKTIRLWDLET-----GECVRTLTGHTSYVSSVAFSP-DGRILSSSSRDKTIKVWDVETGKCLT-------T 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2031953382 154 FDEHRYCVYSTIFSPiNGDLFMSCSGDMTMKIWDVHDISSIQTARVHNYEVLACDWNKFNEHIvCTGAVDKTIKVWDLRn 233
Cdd:cd00200   131 LRGHTDWVNSVAFSP-DGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKL-LSSSSDGTIKLWDLS- 207

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2031953382 234 lnqhgagvvggtsstaSDSSICTLSGHGFAVRRVKFSPHDENIIGSvSYDMSLCIWDTEQGSdnaLLEKYEHHSEFVIGL 313
Cdd:cd00200   208 ----------------TGKCLGTLRGHENGVNSVAFSPDGYLLASG-SEDGTIRVWDLRTGE---CVQTLSGHTNSVTSL 267

                         250       260
                  ....*....|....*....|..
gi 2031953382 314 DFNLEMEDeLASCSWDETVYVW 335
Cdd:cd00200   268 AWSPDGKR-LASGSADGTIRIW 288
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 74-335 8.87e-39

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 140.55  E-value: 8.87e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2031953382  74 NQIISCSGDGSIKVFDTTNalggeGAPVMNFAEHSKEVYSVDYNTvNKDCFVSGSWDNTIKLWNLQAAGAGQtnassveT 153
Cdd:cd00200    64 TYLASGSSDKTIRLWDLET-----GECVRTLTGHTSYVSSVAFSP-DGRILSSSSRDKTIKVWDVETGKCLT-------T 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2031953382 154 FDEHRYCVYSTIFSPiNGDLFMSCSGDMTMKIWDVHDISSIQTARVHNYEVLACDWNKFNEHIvCTGAVDKTIKVWDLRn 233
Cdd:cd00200   131 LRGHTDWVNSVAFSP-DGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKL-LSSSSDGTIKLWDLS- 207

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2031953382 234 lnqhgagvvggtsstaSDSSICTLSGHGFAVRRVKFSPHDENIIGSvSYDMSLCIWDTEQGSdnaLLEKYEHHSEFVIGL 313
Cdd:cd00200   208 ----------------TGKCLGTLRGHENGVNSVAFSPDGYLLASG-SEDGTIRVWDLRTGE---CVQTLSGHTNSVTSL 267

                         250       260
                  ....*....|....*....|..
gi 2031953382 314 DFNLEMEDeLASCSWDETVYVW 335
Cdd:cd00200   268 AWSPDGKR-LASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
75-335 1.20e-37

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 140.43  E-value: 1.20e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2031953382  75 QIISCSGDGSIKVFDTTNalggeGAPVMNFAEHSKEVYSVDYNTVNKdCFVSGSWDNTIKLWNLQAAGAgqtnassVETF 154
Cdd:COG2319   134 TLASGSADGTVRLWDLAT-----GKLLRTLTGHSGAVTSVAFSPDGK-LLASGSDDGTVRLWDLATGKL-------LRTL 200

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2031953382 155 DEHRYCVYSTIFSPiNGDLFMSCSGDMTMKIWDVHDISSIQTARVHNYEVLACDWNKFNEHIVcTGAVDKTIKVWDL--- 231
Cdd:COG2319   201 TGHTGAVRSVAFSP-DGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLA-SGSADGTVRLWDLatg 278

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2031953382 232 ---RNLNQHGAGV-------------VGGTSST------ASDSSICTLSGHGFAVRRVKFSPhDENIIGSVSYDMSLCIW 289
Cdd:COG2319   279 ellRTLTGHSGGVnsvafspdgkllaSGSDDGTvrlwdlATGKLLRTLTGHTGAVRSVAFSP-DGKTLASGSDDGTVRLW 357

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 2031953382 290 DTEQGsdnALLEKYEHHSEFVIGLDFNLEmEDELASCSWDETVYVW 335
Cdd:COG2319   358 DLATG---ELLRTLTGHTGAVTSVAFSPD-GRTLASGSADGTVRLW 399
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 66-343 1.55e-08

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 56.63  E-value: 1.55e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2031953382  66 CTWNEENENQIISCSG-DGSIKVFDTtNALGGEGA----PVMNFAEHSKeVYSVDYNTVNKDCFVSGSWDNTIKLWNLqa 140
Cdd:PLN00181  487 CAIGFDRDGEFFATAGvNKKIKIFEC-ESIIKDGRdihyPVVELASRSK-LSGICWNSYIKSQVASSNFEGVVQVWDV-- 562

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2031953382 141 agagqTNASSVETFDEHRYCVYSTIFSPINGDLFMSCSGDMTMKIWDVHDISSIQTARVhNYEVLACDWNKFNEHIVCTG 220
Cdd:PLN00181  563 -----ARSQLVTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSINQGVSIGTIKT-KANICCVQFPSESGRSLAFG 636

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2031953382 221 AVDKTIKVWDLRNlnqhgagvvggtsstaSDSSICTLSGHGFAVRRVKFSphDENIIGSVSYDMSLCIWD---TEQGSDN 297
Cdd:PLN00181  637 SADHKVYYYDLRN----------------PKLPLCTMIGHSKTVSYVRFV--DSSTLVSSSTDNTLKLWDlsmSISGINE 698

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 2031953382 298 ALLEKYEHHSEF--VIGLDFNlemEDELASCSWDETVYVWMRGeEPVP 343
Cdd:PLN00181  699 TPLHSFMGHTNVknFVGLSVS---DGYIATGSETNEVFVYHKA-FPMP 742
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 98-137 5.95e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.99  E-value: 5.95e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 2031953382   98 GAPVMNFAEHSKEVYSVDYNTvNKDCFVSGSWDNTIKLWN 137
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
98-137 7.88e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.64  E-value: 7.88e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 2031953382  98 GAPVMNFAEHSKEVYSVDYNTvNKDCFVSGSWDNTIKLWN 137
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 74-335 8.87e-39

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 140.55  E-value: 8.87e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2031953382  74 NQIISCSGDGSIKVFDTTNalggeGAPVMNFAEHSKEVYSVDYNTvNKDCFVSGSWDNTIKLWNLQAAGAGQtnassveT 153
Cdd:cd00200    64 TYLASGSSDKTIRLWDLET-----GECVRTLTGHTSYVSSVAFSP-DGRILSSSSRDKTIKVWDVETGKCLT-------T 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2031953382 154 FDEHRYCVYSTIFSPiNGDLFMSCSGDMTMKIWDVHDISSIQTARVHNYEVLACDWNKFNEHIvCTGAVDKTIKVWDLRn 233
Cdd:cd00200   131 LRGHTDWVNSVAFSP-DGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKL-LSSSSDGTIKLWDLS- 207

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2031953382 234 lnqhgagvvggtsstaSDSSICTLSGHGFAVRRVKFSPHDENIIGSvSYDMSLCIWDTEQGSdnaLLEKYEHHSEFVIGL 313
Cdd:cd00200   208 ----------------TGKCLGTLRGHENGVNSVAFSPDGYLLASG-SEDGTIRVWDLRTGE---CVQTLSGHTNSVTSL 267

                         250       260
                  ....*....|....*....|..
gi 2031953382 314 DFNLEMEDeLASCSWDETVYVW 335
Cdd:cd00200   268 AWSPDGKR-LASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
75-335 1.20e-37

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 140.43  E-value: 1.20e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2031953382  75 QIISCSGDGSIKVFDTTNalggeGAPVMNFAEHSKEVYSVDYNTVNKdCFVSGSWDNTIKLWNLQAAGAgqtnassVETF 154
Cdd:COG2319   134 TLASGSADGTVRLWDLAT-----GKLLRTLTGHSGAVTSVAFSPDGK-LLASGSDDGTVRLWDLATGKL-------LRTL 200

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2031953382 155 DEHRYCVYSTIFSPiNGDLFMSCSGDMTMKIWDVHDISSIQTARVHNYEVLACDWNKFNEHIVcTGAVDKTIKVWDL--- 231
Cdd:COG2319   201 TGHTGAVRSVAFSP-DGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLA-SGSADGTVRLWDLatg 278

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2031953382 232 ---RNLNQHGAGV-------------VGGTSST------ASDSSICTLSGHGFAVRRVKFSPhDENIIGSVSYDMSLCIW 289
Cdd:COG2319   279 ellRTLTGHSGGVnsvafspdgkllaSGSDDGTvrlwdlATGKLLRTLTGHTGAVRSVAFSP-DGKTLASGSDDGTVRLW 357

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 2031953382 290 DTEQGsdnALLEKYEHHSEFVIGLDFNLEmEDELASCSWDETVYVW 335
Cdd:COG2319   358 DLATG---ELLRTLTGHTGAVTSVAFSPD-GRTLASGSADGTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
75-335 3.82e-36

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 136.19  E-value: 3.82e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2031953382  75 QIISCSGDGSIKVFDTTNalggeGAPVMNFAEHSKEVYSVDYNTVNKDcFVSGSWDNTIKLWNLQaagagqtNASSVETF 154
Cdd:COG2319    92 LLASASADGTVRLWDLAT-----GLLLRTLTGHTGAVRSVAFSPDGKT-LASGSADGTVRLWDLA-------TGKLLRTL 158

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2031953382 155 DEHRYCVYSTIFSPiNGDLFMSCSGDMTMKIWDVHDISSIQTARVHNYEVLACDWNKFNEHIVcTGAVDKTIKVWDLRN- 233
Cdd:COG2319   159 TGHSGAVTSVAFSP-DGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLA-SGSADGTVRLWDLATg 236

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2031953382 234 -----LNQHGAGV-------------VGGTSST------ASDSSICTLSGHGFAVRRVKFSPhDENIIGSVSYDMSLCIW 289
Cdd:COG2319   237 kllrtLTGHSGSVrsvafspdgrllaSGSADGTvrlwdlATGELLRTLTGHSGGVNSVAFSP-DGKLLASGSDDGTVRLW 315

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 2031953382 290 DTEQGsdnALLEKYEHHSEFVIGLDFNlEMEDELASCSWDETVYVW 335
Cdd:COG2319   316 DLATG---KLLRTLTGHTGAVRSVAFS-PDGKTLASGSDDGTVRLW 357
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 47-290 1.36e-34

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 129.38  E-value: 1.36e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2031953382  47 DSQTMRKLYTFDT-DDGLYDCTWNeeNENQII-SCSGDGSIKVFDTTNalggeGAPVMNFAEHSKEVYSVDYNTVNKdcF 124
Cdd:cd00200    79 DLETGECVRTLTGhTSYVSSVAFS--PDGRILsSSSRDKTIKVWDVET-----GKCLTTLRGHTDWVNSVAFSPDGT--F 149

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2031953382 125 V-SGSWDNTIKLWNLqaagagqTNASSVETFDEHRYCVYSTIFSPiNGDLFMSCSGDMTMKIWDVHDISSIQTARVHNYE 203
Cdd:cd00200   150 VaSSSQDGTIKLWDL-------RTGKCVATLTGHTGEVNSVAFSP-DGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENG 221

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2031953382 204 VLACDWNkFNEHIVCTGAVDKTIKVWDLRnlnqhgagvvggtsstaSDSSICTLSGHGFAVRRVKFSPhDENIIGSVSYD 283
Cdd:cd00200   222 VNSVAFS-PDGYLLASGSEDGTIRVWDLR-----------------TGECVQTLSGHTNSVTSLAWSP-DGKRLASGSAD 282


                  ....*..
gi 2031953382 284 MSLCIWD 290
Cdd:cd00200   283 GTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
11-292 2.36e-32

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 125.79  E-value: 2.36e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2031953382  11 YSVEFSPfeDDKLgVATsqhfgiAGQGRQYILqndRDSQTMRKLYTFD-TDDGLYDCTWNEeNENQIISCSGDGSIKVFD 89
Cdd:COG2319   166 TSVAFSP--DGKL-LAS------GSDDGTVRL---WDLATGKLLRTLTgHTGAVRSVAFSP-DGKLLASGSADGTVRLWD 232

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2031953382  90 TTNalggeGAPVMNFAEHSKEVYSVDYNTVNKdCFVSGSWDNTIKLWNLQaagagqtNASSVETFDEHRYCVYSTIFSPi 169
Cdd:COG2319   233 LAT-----GKLLRTLTGHSGSVRSVAFSPDGR-LLASGSADGTVRLWDLA-------TGELLRTLTGHSGGVNSVAFSP- 298

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2031953382 170 NGDLFMSCSGDMTMKIWDVHDISSIQTARVHNYEVLACDWNKFNEHIVcTGAVDKTIKVWDLRNLNQhgagvvggtssta 249
Cdd:COG2319   299 DGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLA-SGSDDGTVRLWDLATGEL------------- 364

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 2031953382 250 sdssICTLSGHGFAVRRVKFSPhDENIIGSVSYDMSLCIWDTE 292
Cdd:COG2319   365 ----LRTLTGHTGAVTSVAFSP-DGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 104-344 1.62e-28

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 112.81  E-value: 1.62e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2031953382 104 FAEHSKEVYSVDYNTVNKdCFVSGSWDNTIKLWNLQaagagqtNASSVETFDEHRYCVYSTIFSPiNGDLFMSCSGDMTM 183
Cdd:cd00200     5 LKGHTGGVTCVAFSPDGK-LLATGSGDGTIKVWDLE-------TGELLRTLKGHTGPVRDVAASA-DGTYLASGSSDKTI 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2031953382 184 KIWDVHDISSIQTARVHNYEVLACDWNKfNEHIVCTGAVDKTIKVWDLRN------LNQHGAGV-------VGGTSSTAS 250
Cdd:cd00200    76 RLWDLETGECVRTLTGHTSYVSSVAFSP-DGRILSSSSRDKTIKVWDVETgkclttLRGHTDWVnsvafspDGTFVASSS 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2031953382 251 D------------SSICTLSGHGFAVRRVKFSPhDENIIGSVSYDMSLCIWDTEQGsdnALLEKYEHHSEFVIGLDFNLE 318
Cdd:cd00200   155 QdgtiklwdlrtgKCVATLTGHTGEVNSVAFSP-DGEKLLSSSSDGTIKLWDLSTG---KCLGTLRGHENGVNSVAFSPD 230

                         250       260
                  ....*....|....*....|....*..
gi 2031953382 319 mEDELASCSWDETVYVW-MRGEEPVPT 344
Cdd:cd00200   231 -GYLLASGSEDGTIRVWdLRTGECVQT 256
WD40 COG2319
WD40 repeat [General function prediction only];
76-233 2.14e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 94.98  E-value: 2.14e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2031953382  76 IISCSGDGSIKVFDTTNalggeGAPVMNFAEHSKEVYSVDYNTVNKDcFVSGSWDNTIKLWNLQaagagqtNASSVETFD 155
Cdd:COG2319   261 LASGSADGTVRLWDLAT-----GELLRTLTGHSGGVNSVAFSPDGKL-LASGSDDGTVRLWDLA-------TGKLLRTLT 327

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2031953382 156 EHRYCVYSTIFSPiNGDLFMSCSGDMTMKIWDVHDISSIQTARVHNYEVLACDWNKFNEHIVcTGAVDKTIKVWDLRN 233
Cdd:COG2319   328 GHTGAVRSVAFSP-DGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLA-SGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
11-190 5.52e-15

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 76.10  E-value: 5.52e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2031953382  11 YSVEFSPfeDDKLGVATSQHFGIagqgRQYilqndrDSQTMRKLYTFDT-DDGLYDCTWNEeNENQIISCSGDGSIKVFD 89
Cdd:COG2319   250 RSVAFSP--DGRLLASGSADGTV----RLW------DLATGELLRTLTGhSGGVNSVAFSP-DGKLLASGSDDGTVRLWD 316

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2031953382  90 TTNalggeGAPVMNFAEHSKEVYSVDYNTVNKDcFVSGSWDNTIKLWNLQAAGAgqtnassVETFDEHRYCVYSTIFSPi 169
Cdd:COG2319   317 LAT-----GKLLRTLTGHTGAVRSVAFSPDGKT-LASGSDDGTVRLWDLATGEL-------LRTLTGHTGAVTSVAFSP- 382

                         170       180
                  ....*....|....*....|.
gi 2031953382 170 NGDLFMSCSGDMTMKIWDVHD 190
Cdd:COG2319   383 DGRTLASGSADGTVRLWDLAT 403
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 66-343 1.55e-08

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 56.63  E-value: 1.55e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2031953382  66 CTWNEENENQIISCSG-DGSIKVFDTtNALGGEGA----PVMNFAEHSKeVYSVDYNTVNKDCFVSGSWDNTIKLWNLqa 140
Cdd:PLN00181  487 CAIGFDRDGEFFATAGvNKKIKIFEC-ESIIKDGRdihyPVVELASRSK-LSGICWNSYIKSQVASSNFEGVVQVWDV-- 562

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2031953382 141 agagqTNASSVETFDEHRYCVYSTIFSPINGDLFMSCSGDMTMKIWDVHDISSIQTARVhNYEVLACDWNKFNEHIVCTG 220
Cdd:PLN00181  563 -----ARSQLVTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSINQGVSIGTIKT-KANICCVQFPSESGRSLAFG 636

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2031953382 221 AVDKTIKVWDLRNlnqhgagvvggtsstaSDSSICTLSGHGFAVRRVKFSphDENIIGSVSYDMSLCIWD---TEQGSDN 297
Cdd:PLN00181  637 SADHKVYYYDLRN----------------PKLPLCTMIGHSKTVSYVRFV--DSSTLVSSSTDNTLKLWDlsmSISGINE 698

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 2031953382 298 ALLEKYEHHSEF--VIGLDFNlemEDELASCSWDETVYVWMRGeEPVP 343
Cdd:PLN00181  699 TPLHSFMGHTNVknFVGLSVS---DGYIATGSETNEVFVYHKA-FPMP 742
PTZ00421 PTZ00421
coronin; Provisional
 110-253 1.72e-07

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 52.97  E-value: 1.72e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2031953382 110 EVYSVDYNTVNKDCFVSGSWDNTIKLWNLQAAGAGQTNASSVETFDEHRYCVYSTIFSPINGDLFMSCSGDMTMKIWDVH 189
Cdd:PTZ00421   77 PIIDVAFNPFDPQKLFTASEDGTIMGWGIPEEGLTQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVE 156

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2031953382 190 DISSIQTARVHNYEVLACDWNkFNEHIVCTGAVDKTIKVWDLRNlnqhgAGVVGGTSSTASDSS 253
Cdd:PTZ00421  157 RGKAVEVIKCHSDQITSLEWN-LDGSLLCTTSKDKKLNIIDPRD-----GTIVSSVEAHASAKS 214
PTZ00420 PTZ00420
coronin; Provisional
 166-233 3.91e-07

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 51.87  E-value: 3.91e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2031953382 166 FSPINGDLFMSCSGDMTMKIWDV-HDISSIQTARV-------HNYEVLACDWNKFNEHIVCTGAVDKTIKVWDLRN 233
Cdd:PTZ00420   82 FNPCFSEILASGSEDLTIRVWEIpHNDESVKEIKDpqcilkgHKKKISIIDWNPMNYYIMCSSGFDSFVNIWDIEN 157
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 253-335 2.68e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 48.49  E-value: 2.68e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2031953382 253 SICTLSGHGFAVRRVKFSPhDENIIGSVSYDMSLCIWDTEQGSdnaLLEKYEHHSEFVIGLDFNLEmEDELASCSWDETV 332
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSP-DGKLLATGSGDGTIKVWDLETGE---LLRTLKGHTGPVRDVAASAD-GTYLASGSSDKTI 75


                  ...
gi 2031953382 333 YVW 335
Cdd:cd00200    76 RLW 78
PTZ00421 PTZ00421
coronin; Provisional
 209-318 2.67e-05

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 46.04  E-value: 2.67e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2031953382 209 WNKFNEHIVCTGAVDKTIKVWDLRNlnqhgagvVGGTSSTASdsSICTLSGHGFAVRRVKFSPHDENIIGSVSYDMSLCI 288
Cdd:PTZ00421   83 FNPFDPQKLFTASEDGTIMGWGIPE--------EGLTQNISD--PIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNV 152

                          90       100       110
                  ....*....|....*....|....*....|
gi 2031953382 289 WDTEQGSdnaLLEKYEHHSEFVIGLDFNLE 318
Cdd:PTZ00421  153 WDVERGK---AVEVIKCHSDQITSLEWNLD 179
PTZ00421 PTZ00421
coronin; Provisional
 65-288 2.89e-05

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 46.04  E-value: 2.89e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2031953382  65 DCTWNEENENQIISCSGDGSIKVFD------TTNALggegAPVMNFAEHSKEVYSVDYNTVNKDCFVSGSWDNTIKLWNL 138
Cdd:PTZ00421   80 DVAFNPFDPQKLFTASEDGTIMGWGipeeglTQNIS----DPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDV 155

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2031953382 139 QAAGAGQTNASSVETFdehrycvySTIFSPINGDLFMSCSGDMTMKIWD------VHDISSIQTARVHNyevlaCDWNKF 212
Cdd:PTZ00421  156 ERGKAVEVIKCHSDQI--------TSLEWNLDGSLLCTTSKDKKLNIIDprdgtiVSSVEAHASAKSQR-----CLWAKR 222

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2031953382 213 NEHIV---CTGAVDKTIKVWDLRNLNQHGAGVVGGTSSTAS------DSSICTLSGHGFAVRRVkFSPHDENIIGSVSYD 283
Cdd:PTZ00421  223 KDLIItlgCSKSQQRQIMLWDTRKMASPYSTVDLDQSSALFipffdeDTNLLYIGSKGEGNIRC-FELMNERLTFCSSYS 301

                         250
                  ....*....|
gi 2031953382 284 MS-----LCI 288
Cdd:PTZ00421  302 SVephkgLCM 311
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 98-137 5.95e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.99  E-value: 5.95e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 2031953382   98 GAPVMNFAEHSKEVYSVDYNTvNKDCFVSGSWDNTIKLWN 137
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
98-137 7.88e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.64  E-value: 7.88e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 2031953382  98 GAPVMNFAEHSKEVYSVDYNTvNKDCFVSGSWDNTIKLWN 137
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 200-329 1.10e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 44.17  E-value: 1.10e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2031953382 200 HNYEVLACDWNKFNEHIVCTGAVDKTIKVWDLRNLNQhgagvvggtSSTASDSSICTLSGHGFAVRRVKFSPHDENIIGS 279
Cdd:PTZ00420   73 HTSSILDLQFNPCFSEILASGSEDLTIRVWEIPHNDE---------SVKEIKDPQCILKGHKKKISIIDWNPMNYYIMCS 143

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 2031953382 280 VSYDMSLCIWDTEQgsdnallEKYEhhsefvigldFNLEMEDELASCSWD 329
Cdd:PTZ00420  144 SGFDSFVNIWDIEN-------EKRA----------FQINMPKKLSSLKWN 176
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 250-290 2.73e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.06  E-value: 2.73e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 2031953382  250 SDSSICTLSGHGFAVRRVKFSPhDENIIGSVSYDMSLCIWD 290
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 149-187 4.88e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.29  E-value: 4.88e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 2031953382  149 SSVETFDEHRYCVYSTIFSPiNGDLFMSCSGDMTMKIWD 187
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
149-187 7.56e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.94  E-value: 7.56e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2031953382 149 SSVETFDEHRYCVYSTIFSPiNGDLFMSCSGDMTMKIWD 187
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 192-230 1.81e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.75  E-value: 1.81e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 2031953382  192 SSIQTARVHNYEVLACDWNKFNEHIVcTGAVDKTIKVWD 230
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLA-SGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
252-290 2.28e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.40  E-value: 2.28e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2031953382 252 SSICTLSGHGFAVRRVKFSPhDENIIGSVSYDMSLCIWD 290
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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