NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2039338349|emb|CAG5261075|]
View 

GntR family transcriptional regulator [Streptococcus pneumoniae]

Protein Classification

GntR family transcriptional regulator( domain architecture ID 11448193)

GntR family transcriptional regulator simlar to MngR, which is involved in the regulation of mannosyl-glycerate transport and metabolism

CATH:  1.10.10.10
Gene Ontology:  GO:0003677|GO:0003700
PubMed:  33509775|26172911|2060763

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
YhcF COG1725
DNA-binding transcriptional regulator YhcF, GntR family [Transcription];
1-110 1.36e-42

DNA-binding transcriptional regulator YhcF, GntR family [Transcription];


:

Pssm-ID: 441331 [Multi-domain]  Cd Length: 114  Bit Score: 135.69  E-value: 1.36e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2039338349   1 MSWTFDNKKPIYLQIMEKIKLQIVSHTLEPNQQLPTVRELASEAGVNPNTIQRALSDLEREGFVYSKRTTGRFVTKD-KE 79
Cdd:COG1725     1 IRIDFDSGVPIYEQIADQIKEAIASGELKPGDRLPSVRELAAELGVNPNTVAKAYRELEDEGLIETRRGKGTFVAEDaRE 80

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2039338349  80 LIAQSRKQLSEEELEHFVSSMTHFGYEKEEL 110
Cdd:COG1725    81 LLEERREEFLEEALRELVAEARRLGLSLEEL 111
 
Name Accession Description Interval E-value
YhcF COG1725
DNA-binding transcriptional regulator YhcF, GntR family [Transcription];
1-110 1.36e-42

DNA-binding transcriptional regulator YhcF, GntR family [Transcription];


Pssm-ID: 441331 [Multi-domain]  Cd Length: 114  Bit Score: 135.69  E-value: 1.36e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2039338349   1 MSWTFDNKKPIYLQIMEKIKLQIVSHTLEPNQQLPTVRELASEAGVNPNTIQRALSDLEREGFVYSKRTTGRFVTKD-KE 79
Cdd:COG1725     1 IRIDFDSGVPIYEQIADQIKEAIASGELKPGDRLPSVRELAAELGVNPNTVAKAYRELEDEGLIETRRGKGTFVAEDaRE 80

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2039338349  80 LIAQSRKQLSEEELEHFVSSMTHFGYEKEEL 110
Cdd:COG1725    81 LLEERREEFLEEALRELVAEARRLGLSLEEL 111
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 10-75 4.27e-21

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 79.80  E-value: 4.27e-21
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2039338349  10 PIYLQIMEKIKLQIVSHTLEPNQQLPTVRELASEAGVNPNTIQRALSDLEREGFVYSKRTTGRFVT 75
Cdd:cd07377     1 PLYEQIADQLREAILSGELKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
15-74 3.93e-15

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 64.52  E-value: 3.93e-15
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2039338349   15 IMEKIKLQIVSHTLEPNQQLPTVRELASEAGVNPNTIQRALSDLEREGFVYSKRTTGRFV 74
Cdd:smart00345   1 VAERLREDIVSGELRPGDKLPSERELAAQLGVSRTTVREALSRLEAEGLVQRRPGSGTFV 60
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 12-74 1.99e-14

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 62.63  E-value: 1.99e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2039338349  12 YLQIMEKIKLQIVSHTLEPNQQLPTVRELASEAGVNPNTIQRALSDLEREGFVYSKRTTGRFV 74
Cdd:pfam00392   2 YEQVYARLREDILSGRLRPGDKLPSERELAAEFGVSRTTVREALRRLEAEGLVERRQGRGTFV 64
PRK15481 PRK15481
transcriptional regulatory protein PtsJ; Provisional
 14-83 3.43e-09

transcriptional regulatory protein PtsJ; Provisional


Pssm-ID: 185378 [Multi-domain]  Cd Length: 431  Bit Score: 52.74  E-value: 3.43e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2039338349  14 QIMEKIKLQIVSHTLEPNQQLPTVRELASEAGVNPNTIQRALSDLEREGFVYSKRTTGRFVTKDKELIAQ 83
Cdd:PRK15481    9 EIFDSIRQLIQAGRLRPGDSLPPVRELASELGVNRNTVAAAYKRLVTAGLAQSQGRNGTVIRGSPSPVAL 78
C_P_lyase_phnF TIGR02325
phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for ...
 11-85 1.63e-08

phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for this family are predicted helix-turn-helix transcriptional regulatory proteins of the broader gntR and are found associated with genes for the import and degradation of phosphonates and/or related compounds (e.g. phosphonites) with a direct C-P bond. [Transport and binding proteins, Anions, Regulatory functions, DNA interactions]


Pssm-ID: 131378 [Multi-domain]  Cd Length: 238  Bit Score: 50.55  E-value: 1.63e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2039338349  11 IYLQIMEKIKLQIVSHTLEPNQQLPTVRELASEAGVNPNTIQRALSDLEREGFVYSKRTTGRFVTK---DKELIAQSR 85
Cdd:TIGR02325   9 LWRQIADKIEQEIAAGHLRAGDYLPAEMQLAERFGVNRHTVRRAIAALVERGLLRAEQGRGTFVAArriDYPLSARTR 86
 
Name Accession Description Interval E-value
YhcF COG1725
DNA-binding transcriptional regulator YhcF, GntR family [Transcription];
1-110 1.36e-42

DNA-binding transcriptional regulator YhcF, GntR family [Transcription];


Pssm-ID: 441331 [Multi-domain]  Cd Length: 114  Bit Score: 135.69  E-value: 1.36e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2039338349   1 MSWTFDNKKPIYLQIMEKIKLQIVSHTLEPNQQLPTVRELASEAGVNPNTIQRALSDLEREGFVYSKRTTGRFVTKD-KE 79
Cdd:COG1725     1 IRIDFDSGVPIYEQIADQIKEAIASGELKPGDRLPSVRELAAELGVNPNTVAKAYRELEDEGLIETRRGKGTFVAEDaRE 80

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2039338349  80 LIAQSRKQLSEEELEHFVSSMTHFGYEKEEL 110
Cdd:COG1725    81 LLEERREEFLEEALRELVAEARRLGLSLEEL 111
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 10-75 4.27e-21

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 79.80  E-value: 4.27e-21
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2039338349  10 PIYLQIMEKIKLQIVSHTLEPNQQLPTVRELASEAGVNPNTIQRALSDLEREGFVYSKRTTGRFVT 75
Cdd:cd07377     1 PLYEQIADQLREAILSGELKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
6-106 3.10e-19

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 79.52  E-value: 3.10e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2039338349   6 DNKKPIYLQIMEKIKLQIVSHTLEPNQQLPTVRELASEAGVNPNTIQRALSDLEREGFVYSKRTTGRFVtkdkeliAQSR 85
Cdd:COG2188     1 SSPVPLYLQIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFV-------AEPK 73

                          90       100
                  ....*....|....*....|.
gi 2039338349  86 KQLSEEELEHFVSSMTHFGYE 106
Cdd:COG2188    74 IEYPLSRLTSFTEELRARGRE 94
ARO8 COG1167
DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain ...
 1-75 3.15e-19

DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain [Transcription, Amino acid transport and metabolism]; DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain is part of the Pathway/BioSystem: Lysine biosynthesis


Pssm-ID: 440781 [Multi-domain]  Cd Length: 471  Bit Score: 81.41  E-value: 3.15e-19
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2039338349   1 MSWTFD--NKKPIYLQIMEKIKLQIVSHTLEPNQQLPTVRELASEAGVNPNTIQRALSDLEREGFVYSKRTTGRFVT 75
Cdd:COG1167     1 MLIRLDrdSSGPLYLQLADALREAILSGRLPPGDRLPSSRELAAQLGVSRSTVVRAYEELEAEGLIESRPGSGTFVA 77
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
15-74 3.93e-15

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 64.52  E-value: 3.93e-15
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2039338349   15 IMEKIKLQIVSHTLEPNQQLPTVRELASEAGVNPNTIQRALSDLEREGFVYSKRTTGRFV 74
Cdd:smart00345   1 VAERLREDIVSGELRPGDKLPSERELAAQLGVSRTTVREALSRLEAEGLVQRRPGSGTFV 60
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 12-74 1.99e-14

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 62.63  E-value: 1.99e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2039338349  12 YLQIMEKIKLQIVSHTLEPNQQLPTVRELASEAGVNPNTIQRALSDLEREGFVYSKRTTGRFV 74
Cdd:pfam00392   2 YEQVYARLREDILSGRLRPGDKLPSERELAAEFGVSRTTVREALRRLEAEGLVERRQGRGTFV 64
FadR COG2186
DNA-binding transcriptional regulator, FadR family [Transcription];
8-75 2.64e-11

DNA-binding transcriptional regulator, FadR family [Transcription];


Pssm-ID: 441789 [Multi-domain]  Cd Length: 232  Bit Score: 58.02  E-value: 2.64e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2039338349   8 KKPIYLQIMEKIKLQIVSHTLEPNQQLPTVRELASEAGVNPNTIQRALSDLEREGFVYSKRTTGRFVT 75
Cdd:COG2186     5 RRSLAEQVAEQLRELILSGELKPGDRLPSERELAEQLGVSRTTVREALRALEALGLVEVRQGGGTFVR 72
PRK15481 PRK15481
transcriptional regulatory protein PtsJ; Provisional
 14-83 3.43e-09

transcriptional regulatory protein PtsJ; Provisional


Pssm-ID: 185378 [Multi-domain]  Cd Length: 431  Bit Score: 52.74  E-value: 3.43e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2039338349  14 QIMEKIKLQIVSHTLEPNQQLPTVRELASEAGVNPNTIQRALSDLEREGFVYSKRTTGRFVTKDKELIAQ 83
Cdd:PRK15481    9 EIFDSIRQLIQAGRLRPGDSLPPVRELASELGVNRNTVAAAYKRLVTAGLAQSQGRNGTVIRGSPSPVAL 78
PRK10421 PRK10421
DNA-binding transcriptional repressor LldR; Provisional
 14-92 6.32e-09

DNA-binding transcriptional repressor LldR; Provisional


Pssm-ID: 236690 [Multi-domain]  Cd Length: 253  Bit Score: 51.69  E-value: 6.32e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2039338349  14 QIMEKIKLQIVSHTLEPNQQLPTVRELASEAGVNPNTIQRALSDLEREGFVYSKRTTGRFV-----TKDKELIAQSRKQL 88
Cdd:PRK10421    6 EVADRVRALIEEKNLEAGMKLPAERQLAMQLGVSRNSLREALAKLVSEGVLLSRRGGGTFIrwrheTWSEQNIVQPLKTL 85


                  ....
gi 2039338349  89 SEEE 92
Cdd:PRK10421   86 MADD 89
C_P_lyase_phnF TIGR02325
phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for ...
 11-85 1.63e-08

phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for this family are predicted helix-turn-helix transcriptional regulatory proteins of the broader gntR and are found associated with genes for the import and degradation of phosphonates and/or related compounds (e.g. phosphonites) with a direct C-P bond. [Transport and binding proteins, Anions, Regulatory functions, DNA interactions]


Pssm-ID: 131378 [Multi-domain]  Cd Length: 238  Bit Score: 50.55  E-value: 1.63e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2039338349  11 IYLQIMEKIKLQIVSHTLEPNQQLPTVRELASEAGVNPNTIQRALSDLEREGFVYSKRTTGRFVTK---DKELIAQSR 85
Cdd:TIGR02325   9 LWRQIADKIEQEIAAGHLRAGDYLPAEMQLAERFGVNRHTVRRAIAALVERGLLRAEQGRGTFVAArriDYPLSARTR 86
PRK11402 PRK11402
transcriptional regulator PhoB;
9-112 5.13e-08

transcriptional regulator PhoB;


Pssm-ID: 183118 [Multi-domain]  Cd Length: 241  Bit Score: 49.06  E-value: 5.13e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2039338349   9 KPIYLQIMEKIKLQIVSHTLEPNQQLPTVRELASEAGVNPNTIQRALSDLEREGFVYSKRTTGRFVTKDK---ELIAQS- 84
Cdd:PRK11402    8 QLLYATVRQRLLDDIAQGVYQAGQQIPTENELCTQYNVSRITIRKAISDLVADGVLIRWQGKGTFVQSQKvenALLTVSg 87

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 2039338349  85 --------RKQLSEEELEHFVSSMTHFGyEKEELPG 112
Cdd:PRK11402   88 ftdfgvsqGKATKEKVIEQERVSAAPFC-EKLNIPG 122
HTH_36 pfam13730
Helix-turn-helix domain;
21-64 9.70e-06

Helix-turn-helix domain;


Pssm-ID: 463970 [Multi-domain]  Cd Length: 55  Bit Score: 40.17  E-value: 9.70e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 2039338349  21 LQIVSHTLEPNQQLPTVRELASEAGVNPNTIQRALSDLEREGFV 64
Cdd:pfam13730  12 LILASYANKDGGCFPSVETLAKRLGLSRRTIQRAIKELEELGYL 55
PRK09764 PRK09764
GntR family transcriptional regulator;
8-78 1.35e-05

GntR family transcriptional regulator;


Pssm-ID: 182065 [Multi-domain]  Cd Length: 240  Bit Score: 42.51  E-value: 1.35e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2039338349   8 KKPIYLQIMEKIKLQIVSHTLEPNQQLPTVRELASEAGVNPNTIQRALSDLEREGFVYSKRTTGRFVTKDK 78
Cdd:PRK09764    3 HKPLYRQIADRIREQIARGELKPGDALPTESALQTEFGVSRVTVRQALRQLVEQQILESIQGSGTYVKEER 73
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
14-95 1.97e-05

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 41.83  E-value: 1.97e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2039338349  14 QIMEKIKLQIVSHTLEPNQQLpTVRELASEAGVNPNTIQRALSDLEREGFVYSKRTTGRFVTkdkeliaqsrkQLSEEEL 93
Cdd:COG1802    15 QVYEALREAILSGELPPGERL-SEAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARVA-----------PLSPEEI 82


                  ..
gi 2039338349  94 EH 95
Cdd:COG1802    83 RE 84
pdhR PRK09464
pyruvate dehydrogenase complex transcriptional repressor PdhR;
15-76 2.84e-05

pyruvate dehydrogenase complex transcriptional repressor PdhR;


Pssm-ID: 181879 [Multi-domain]  Cd Length: 254  Bit Score: 41.54  E-value: 2.84e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2039338349  15 IMEKIKLQIVSHTLEPNQQLPTVRELASEAGVNPNTIQRALSDLEREGFVYSKRTTGRFVTK 76
Cdd:PRK09464   15 IEQQLEFLILEGTLRPGEKLPPERELAKQFDVSRPSLREAIQRLEAKGLLLRRQGGGTFVQS 76
COG2345 COG2345
Predicted transcriptional regulator, ArsR family [Transcription];
36-72 3.63e-05

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441914 [Multi-domain]  Cd Length: 217  Bit Score: 41.06  E-value: 3.63e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 2039338349  36 TVRELASEAGVNPNTIQRALSDLEREGFVYS---KRTTGR 72
Cdd:COG2345    29 TAAELAEALGLTPNAVRRHLDALEEEGLVEReteRRGRGR 68
Rrf2 pfam02082
Iron-dependent Transcriptional regulator; Several proteins in this family form iron-sulfur ...
 21-68 3.90e-05

Iron-dependent Transcriptional regulator; Several proteins in this family form iron-sulfur clusters enabling iron dependent DNA transcription regulation. The iron binding is mediated by three conserved cysteine residues. Members of this family can also bind O-acetyl-L-serine, [Fe-S] and nitric oxide (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 396591 [Multi-domain]  Cd Length: 131  Bit Score: 40.23  E-value: 3.90e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 2039338349  21 LQIVSH-TLEPNQQLPTVRELASEAGVNPNTIQRALSDLEREGFVYSKR 68
Cdd:pfam02082   9 LHALLYlALHPGGEPVTSEEIAERQNISPVYLEKILAKLRKAGLVESVR 57
PRK14999 PRK14999
histidine utilization repressor; Provisional
 10-78 7.45e-05

histidine utilization repressor; Provisional


Pssm-ID: 184961 [Multi-domain]  Cd Length: 241  Bit Score: 40.30  E-value: 7.45e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2039338349  10 PIYLQIMEKIKLQIVSHTLEPNQQLPTVRELASEAGVNPNTIQRALSDLEREGFVYSKRTTGRFVTKDK 78
Cdd:PRK14999   12 PFYETVKQDICKKIAGGVWQPHDRIPSEAELVAQYGFSRMTINRALRELTDEGWLVRLQGVGTFVAEPK 80
IclR COG1414
DNA-binding transcriptional regulator, IclR family [Transcription];
36-74 8.54e-05

DNA-binding transcriptional regulator, IclR family [Transcription];


Pssm-ID: 441024 [Multi-domain]  Cd Length: 253  Bit Score: 40.19  E-value: 8.54e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2039338349  36 TVRELASEAGVNPNTIQRALSDLEREGFVYSKRTTGRFV 74
Cdd:COG1414    26 SLSELARRLGLPKSTVHRLLATLEEEGYVERDPEGGRYR 64
PRK10225 PRK10225
Uxu operon transcriptional regulator;
12-74 1.11e-04

Uxu operon transcriptional regulator;


Pssm-ID: 182318 [Multi-domain]  Cd Length: 257  Bit Score: 40.00  E-value: 1.11e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2039338349  12 YLQIMEKIKLQIVSHTLEPNQQLPTVRELASEAGVNPNTIQRALSDLEREGFVYSKRTTGRFV 74
Cdd:PRK10225   11 YQEVGAMIRDLIIKTPYNPGERLPPEREIAEMLDVTRTVVREALIMLEIKGLVEVRRGAGIYV 73
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 36-69 3.40e-04

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 36.51  E-value: 3.40e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 2039338349  36 TVRELASEAGVNPNTIQRALSDLEREGFVYSKRT 69
Cdd:cd00090    22 TVSELAERLGLSQSTVSRHLKKLEEAGLVESRRE 55
LexA COG1974
SOS-response transcriptional repressor LexA (RecA-mediated autopeptidase) [Transcription, ...
 14-72 4.98e-04

SOS-response transcriptional repressor LexA (RecA-mediated autopeptidase) [Transcription, Signal transduction mechanisms];


Pssm-ID: 441577 [Multi-domain]  Cd Length: 199  Bit Score: 37.97  E-value: 4.98e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2039338349  14 QIMEKIKLQIVSHTLepnqqLPTVRELASEAGVNPNTIQRALSDLEREGFVysKRTTGR 72
Cdd:COG1974    10 EILDFIKEYIRERGY-----PPSQREIAEALGLSSSAVHRHLKALEKKGYL--RRDPGK 61
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
36-88 5.22e-04

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 36.03  E-value: 5.22e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2039338349   36 TVRELASEAGVNPNTIQRALSDLEREGFVYSKRT-TGRFVTKDKELIAQSRKQL 88
Cdd:smart00418  12 CVCELAEILGLSQSTVSHHLKKLREAGLVESRREgKRVYYSLTDEKVADLLEEL 65
IscR COG1959
DNA-binding transcriptional regulator, IscR family [Transcription];
28-68 7.06e-04

DNA-binding transcriptional regulator, IscR family [Transcription];


Pssm-ID: 441562  Cd Length: 141  Bit Score: 36.74  E-value: 7.06e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 2039338349  28 LEPNQQLPTVRELASEAGVNPNTIQRALSDLEREGFVYSKR 68
Cdd:COG1959    18 LHPGGEPVTSKEIAERQGISPSYLEKILQKLRKAGLVESVR 58
HTH_Crp_2 pfam13545
Crp-like helix-turn-helix domain; This family represents a crp-like helix-turn-helix domain ...
 36-79 7.39e-04

Crp-like helix-turn-helix domain; This family represents a crp-like helix-turn-helix domain that is likely to bind DNA.


Pssm-ID: 463917 [Multi-domain]  Cd Length: 68  Bit Score: 35.51  E-value: 7.39e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 2039338349  36 TVRELASEAGVNPNTIQRALSDLEREGFVyskrTTGRFVTKDKE 79
Cdd:pfam13545  24 TQEDLADLLGTTRETVSRVLSELRREGLI----ERGRITILDPE 63
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
36-103 1.10e-03

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 36.49  E-value: 1.10e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2039338349  36 TVRELASEAGVNPNTIQRALSDLEREGFVYSKR--TTGRFVT-----KDKELIAQSRK-----------QLSEEELEHFV 97
Cdd:COG1846    54 TQSELAERLGLTKSTVSRLLDRLEEKGLVEREPdpEDRRAVLvrlteKGRALLEEARPaleallaellaGLSEEELEALL 133


                  ....*.
gi 2039338349  98 SSMTHF 103
Cdd:COG1846   134 RLLRRL 139
HTH_IclR pfam09339
IclR helix-turn-helix domain;
36-65 1.73e-03

IclR helix-turn-helix domain;


Pssm-ID: 430539 [Multi-domain]  Cd Length: 52  Bit Score: 33.92  E-value: 1.73e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 2039338349  36 TVRELASEAGVNPNTIQRALSDLEREGFVY 65
Cdd:pfam09339  20 TLTEIARRTGLPKSTAHRLLQTLVELGYVE 49
InsE COG2963
Transposase InsE and inactivated derivatives [Mobilome: prophages, transposons];
20-94 1.90e-03

Transposase InsE and inactivated derivatives [Mobilome: prophages, transposons];


Pssm-ID: 442203 [Multi-domain]  Cd Length: 93  Bit Score: 34.90  E-value: 1.90e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2039338349  20 KLQIVSHTLEPNQqlpTVRELASEAGVNPNTIQRALSDLEREGFVYSKRTTGrfVTKDKELIAQSRKQLSEEELE 94
Cdd:COG2963    13 KAEAVRLVLEGGA---SVAEVARELGISPSTLYRWVRQYREGGLGGFPGDGR--TTPEQAEIRRLRKELRRLEME 82
HTH_ICLR smart00346
helix_turn_helix isocitrate lyase regulation;
36-73 2.04e-03

helix_turn_helix isocitrate lyase regulation;


Pssm-ID: 214629 [Multi-domain]  Cd Length: 91  Bit Score: 34.87  E-value: 2.04e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2039338349   36 TVRELASEAGVNPNTIQRALSDLEREGFVYSKRTTGRF 73
Cdd:smart00346  22 TLAELAERLGLSKSTAHRLLNTLQELGYVEQDGQNGRY 59
HTH_CRP cd00092
helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic ...
 31-74 5.05e-03

helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family.


Pssm-ID: 238044 [Multi-domain]  Cd Length: 67  Bit Score: 33.41  E-value: 5.05e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 2039338349  31 NQQLP-TVRELASEAGVNPNTIQRALSDLEREGFVySKRTTGRFV 74
Cdd:cd00092    21 LVQLPlTRQEIADYLGLTRETVSRTLKELEEEGLI-SRRGRGKYR 64
HTH_CRP smart00419
helix_turn_helix, cAMP Regulatory protein;
31-74 5.32e-03

helix_turn_helix, cAMP Regulatory protein;


Pssm-ID: 128696 [Multi-domain]  Cd Length: 48  Bit Score: 32.80  E-value: 5.32e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 2039338349   31 NQQLP-TVRELASEAGVNPNTIQRALSDLEREGFVysKRTTGRFV 74
Cdd:smart00419   4 RVRLPlTRQEIAELLGLTRETVSRTLKRLEKEGLI--SREGGRIV 46
COG1777 COG1777
Predicted transcriptional regulator, ArsR family [Transcription];
36-69 5.84e-03

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441383  Cd Length: 113  Bit Score: 33.85  E-value: 5.84e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 2039338349  36 TVRELASEAGVNPNTIQRALSDLEREGFVYSKRT 69
Cdd:COG1777    32 YVSELARELGVSRQAVYKHLRKLEEAGLVESYRE 65
HTH_24 pfam13412
Winged helix-turn-helix DNA-binding;
36-64 6.97e-03

Winged helix-turn-helix DNA-binding;


Pssm-ID: 404317 [Multi-domain]  Cd Length: 45  Bit Score: 32.41  E-value: 6.97e-03
                          10        20
                  ....*....|....*....|....*....
gi 2039338349  36 TVRELASEAGVNPNTIQRALSDLEREGFV 64
Cdd:pfam13412  17 SQRELAERLGLSPSTVNRRLKRLEEEGVI 45
COG2512 COG2512
Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain ...
 36-72 8.21e-03

Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain [General function prediction only];


Pssm-ID: 442002 [Multi-domain]  Cd Length: 80  Bit Score: 32.96  E-value: 8.21e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 2039338349  36 TVRELASEAGVNPNTIQRALSDLEREGFVYSKRtTGR 72
Cdd:COG2512    32 TQSEIVKETGWSKSKVSRLLSRLEERGLIEKER-VGR 67
YrhO COG1378
Sugar-specific transcriptional regulator TrmB [Transcription];
36-94 8.33e-03

Sugar-specific transcriptional regulator TrmB [Transcription];


Pssm-ID: 440988 [Multi-domain]  Cd Length: 238  Bit Score: 34.61  E-value: 8.33e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2039338349  36 TVRELASEAGVNPNTIQRALSDLEREGFVY-SKRTTGRFVTKDKELIAQSRKQLSEEELE 94
Cdd:COG1378    29 TASELAKASGVPRSRVYDVLESLEEKGLVEvSEGRPKRYRAVPPEEALERLLEEREEELE 88
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH