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Conserved domains on  [gi|2038653459|emb|CAG5415191|]
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HIT family protein [Streptococcus pneumoniae]

Protein Classification

HIT family protein( domain architecture ID 10001677)

HIT (Histidine triad) family protein, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), is part of a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides

CATH:  3.30.428.10
Gene Ontology:  GO:1904047
PubMed:  1472710|9323207|12504684|12119013
SCOP:  3000223

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HinT COG0537
Purine nucleoside phosphoramidase/Ap4A hydrolase, histidine triade (HIT) family [Nucleotide ...
 1-114 3.17e-22

Purine nucleoside phosphoramidase/Ap4A hydrolase, histidine triade (HIT) family [Nucleotide transport and metabolism, General function prediction only];


:

Pssm-ID: 440303 [Multi-domain]  Cd Length: 133  Bit Score: 85.77  E-value: 3.17e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038653459   1 MCLICQrieLIKKGENPYFVKELETGYLVIGDHQYFAGYSLFLAKEHVTELHHLEKETRLRFLEEMSLIQEAVAKAFTAE 80
Cdd:COG0537     2 DCIFCK---IIAGEIPALIVYEDEHVLAFLDINPYAPGHTLVIPKRHVASLFDLTPEELAELMRLAQKVAKALRKALGPD 78

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 2038653459  81 KMNIELL-----GNGDAHLHWHLFPRRTGDMNGHGLKGR 114
Cdd:COG0537    79 GFNLGINngeaaGQTVPHLHVHVIPRYEGDDNFMPVIGT 117
 
Name Accession Description Interval E-value
HinT COG0537
Purine nucleoside phosphoramidase/Ap4A hydrolase, histidine triade (HIT) family [Nucleotide ...
 1-114 3.17e-22

Purine nucleoside phosphoramidase/Ap4A hydrolase, histidine triade (HIT) family [Nucleotide transport and metabolism, General function prediction only];


Pssm-ID: 440303 [Multi-domain]  Cd Length: 133  Bit Score: 85.77  E-value: 3.17e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038653459   1 MCLICQrieLIKKGENPYFVKELETGYLVIGDHQYFAGYSLFLAKEHVTELHHLEKETRLRFLEEMSLIQEAVAKAFTAE 80
Cdd:COG0537     2 DCIFCK---IIAGEIPALIVYEDEHVLAFLDINPYAPGHTLVIPKRHVASLFDLTPEELAELMRLAQKVAKALRKALGPD 78

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 2038653459  81 KMNIELL-----GNGDAHLHWHLFPRRTGDMNGHGLKGR 114
Cdd:COG0537    79 GFNLGINngeaaGQTVPHLHVHVIPRYEGDDNFMPVIGT 117
HIT pfam01230
HIT domain;
38-104 3.56e-08

HIT domain;


Pssm-ID: 395984 [Multi-domain]  Cd Length: 98  Bit Score: 48.46  E-value: 3.56e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2038653459  38 GYSLFLAKEHVTELHHLEKETRLRFLEEMSLIQEAVAKAFTAE-----KMNIELLGNGDAHLHWHLFPRRTG 104
Cdd:pfam01230  27 GHILVIPKKHIRELHDLTPEELGDLMSVAQKVARALGKVFKADgyrivINNGAHAGQSVPHLHIHVIPRRKH 98
HINT_subgroup cd01277
HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the ...
 1-101 9.26e-06

HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life. Although the biochemical function has not been characterised for many of the members of this subgroup, the proteins from Yeast have been shown to be involved in secretion, peroxisome formation and gene expression.


Pssm-ID: 238608 [Multi-domain]  Cd Length: 103  Bit Score: 42.21  E-value: 9.26e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038653459   1 MCLICQrielIKKGENP-YFVKELEtGYLVIGDHQYFA-GYSLFLAKEHVTELHHLEKETRLRFLEEMSLIQEAVAKAFT 78
Cdd:cd01277     1 DCIFCK----IIAGEIPsYKVYEDD-HVLAFLDINPASkGHTLVIPKKHYENLLDLDPEELAELILAAKKVARALKKALK 75

                          90       100
                  ....*....|....*....|....*....
gi 2038653459  79 AEKMNIeLLGNGDA------HLHWHLFPR 101
Cdd:cd01277    76 ADGLNI-LQNNGRAagqvvfHVHVHVIPR 103
 
Name Accession Description Interval E-value
HinT COG0537
Purine nucleoside phosphoramidase/Ap4A hydrolase, histidine triade (HIT) family [Nucleotide ...
 1-114 3.17e-22

Purine nucleoside phosphoramidase/Ap4A hydrolase, histidine triade (HIT) family [Nucleotide transport and metabolism, General function prediction only];


Pssm-ID: 440303 [Multi-domain]  Cd Length: 133  Bit Score: 85.77  E-value: 3.17e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038653459   1 MCLICQrieLIKKGENPYFVKELETGYLVIGDHQYFAGYSLFLAKEHVTELHHLEKETRLRFLEEMSLIQEAVAKAFTAE 80
Cdd:COG0537     2 DCIFCK---IIAGEIPALIVYEDEHVLAFLDINPYAPGHTLVIPKRHVASLFDLTPEELAELMRLAQKVAKALRKALGPD 78

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 2038653459  81 KMNIELL-----GNGDAHLHWHLFPRRTGDMNGHGLKGR 114
Cdd:COG0537    79 GFNLGINngeaaGQTVPHLHVHVIPRYEGDDNFMPVIGT 117
HIT pfam01230
HIT domain;
38-104 3.56e-08

HIT domain;


Pssm-ID: 395984 [Multi-domain]  Cd Length: 98  Bit Score: 48.46  E-value: 3.56e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2038653459  38 GYSLFLAKEHVTELHHLEKETRLRFLEEMSLIQEAVAKAFTAE-----KMNIELLGNGDAHLHWHLFPRRTG 104
Cdd:pfam01230  27 GHILVIPKKHIRELHDLTPEELGDLMSVAQKVARALGKVFKADgyrivINNGAHAGQSVPHLHIHVIPRRKH 98
HINT_subgroup cd01277
HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the ...
 1-101 9.26e-06

HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life. Although the biochemical function has not been characterised for many of the members of this subgroup, the proteins from Yeast have been shown to be involved in secretion, peroxisome formation and gene expression.


Pssm-ID: 238608 [Multi-domain]  Cd Length: 103  Bit Score: 42.21  E-value: 9.26e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038653459   1 MCLICQrielIKKGENP-YFVKELEtGYLVIGDHQYFA-GYSLFLAKEHVTELHHLEKETRLRFLEEMSLIQEAVAKAFT 78
Cdd:cd01277     1 DCIFCK----IIAGEIPsYKVYEDD-HVLAFLDINPASkGHTLVIPKKHYENLLDLDPEELAELILAAKKVARALKKALK 75

                          90       100
                  ....*....|....*....|....*....
gi 2038653459  79 AEKMNIeLLGNGDA------HLHWHLFPR 101
Cdd:cd01277    76 ADGLNI-LQNNGRAagqvvfHVHVHVIPR 103
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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