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Conserved domains on  [gi|2038652772|emb|CAG5416474|]
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ThiW superfamily protein [Streptococcus pneumoniae]

Protein Classification

energy coupling factor transporter S component ThiW( domain architecture ID 10560047)

energy coupling factor transporter S component ThiW acts in transport of a thiazole precursor of thiamine

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ThiW pfam09512
Thiamine-precursor transporter protein (ThiW); Levels of thiamine pyrophosphate (TPP) or ...
 11-157 2.90e-49

Thiamine-precursor transporter protein (ThiW); Levels of thiamine pyrophosphate (TPP) or thiamine regulate transcription or translation of a number of thiamine biosynthesis, salvage, or transport genes in a wide range of prokaryotes. The mechanism involves direct binding, with no protein involved, to a structural element called THI found in the untranslated upstream region of thiamine metabolism gene operons. This element is called a riboswitch and is seen also for other metabolites such as FMN and glycine. This protein family consists of proteins identified in operons controlled by the THI riboswitch and designated ThiW. The hydrophobic nature of this protein and reconstructed metabolic background suggests that this protein acts in transport of a thiazole precursor of thiamine.


:

Pssm-ID: 430656  Cd Length: 150  Bit Score: 156.24  E-value: 2.90e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038652772  11 LTILSMMIALDVVLTPIFRI----EGMAPMSSVVNILAGIMMGPVYALAMATVTAFIRMTTQGIPPLALTGATFGALLAG 86
Cdd:pfam09512   1 LTLAAVLIALGVALSPIFSIpvgvAKVFPVQHAINVLAGVLLGPWYALAVALVISLLRNLLGTGTLLAFPGSMFGALLAG 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2038652772  87 LFYKYGRKFYFSALGEIVGTGIIGSIVSYPVMVLFTGSAAKLswFIYTPRFFGATLIGTAISFIAFRFLIK 157
Cdd:pfam09512  81 LLYRYTRKLYLAALGEVLGTGIIGALLAYPVAPLLMGSEAAL--FFFIPPFILSTLIGSVIGYIVLKALKK 149
 
Name Accession Description Interval E-value
ThiW pfam09512
Thiamine-precursor transporter protein (ThiW); Levels of thiamine pyrophosphate (TPP) or ...
 11-157 2.90e-49

Thiamine-precursor transporter protein (ThiW); Levels of thiamine pyrophosphate (TPP) or thiamine regulate transcription or translation of a number of thiamine biosynthesis, salvage, or transport genes in a wide range of prokaryotes. The mechanism involves direct binding, with no protein involved, to a structural element called THI found in the untranslated upstream region of thiamine metabolism gene operons. This element is called a riboswitch and is seen also for other metabolites such as FMN and glycine. This protein family consists of proteins identified in operons controlled by the THI riboswitch and designated ThiW. The hydrophobic nature of this protein and reconstructed metabolic background suggests that this protein acts in transport of a thiazole precursor of thiamine.


Pssm-ID: 430656  Cd Length: 150  Bit Score: 156.24  E-value: 2.90e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038652772  11 LTILSMMIALDVVLTPIFRI----EGMAPMSSVVNILAGIMMGPVYALAMATVTAFIRMTTQGIPPLALTGATFGALLAG 86
Cdd:pfam09512   1 LTLAAVLIALGVALSPIFSIpvgvAKVFPVQHAINVLAGVLLGPWYALAVALVISLLRNLLGTGTLLAFPGSMFGALLAG 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2038652772  87 LFYKYGRKFYFSALGEIVGTGIIGSIVSYPVMVLFTGSAAKLswFIYTPRFFGATLIGTAISFIAFRFLIK 157
Cdd:pfam09512  81 LLYRYTRKLYLAALGEVLGTGIIGALLAYPVAPLLMGSEAAL--FFFIPPFILSTLIGSVIGYIVLKALKK 149
thiW TIGR02359
energy coupling factor transporter S component ThiW; Levels of thiamine pyrophosphate (TPP) or ...
 8-162 1.08e-40

energy coupling factor transporter S component ThiW; Levels of thiamine pyrophosphate (TPP) or thiamine regulate transcription or translation of a number of thiamine biosynthesis, salvage, or transport genes in a wide range of prokaryotes. The mechanism involves direct binding, with no protein involved,to a structural element called THI found in the untranslated upstream region of thiamine metabolism gene operons. This element is called a riboswitch and is seen also for other metabolites such as FMN and glycine. This protein family consists of proteins identified in operons controlled by the THI riboswitch and designated ThiW. The hydrophobic nature of this protein and reconstructed metabolic background suggests that this protein acts in transport of a thiazole precursor of thiamine. [Transport and binding proteins, Other, Biosynthesis of cofactors, prosthetic groups, and carriers, Thiamine]


Pssm-ID: 131412  Cd Length: 160  Bit Score: 134.45  E-value: 1.08e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038652772   8 VHKLTILSMMIALDVVLTPIFRIEG----MAPMSSVVNILAGIMMGPVYALAMATVTAFIRMTTQGIPPLALTGATFGAL 83
Cdd:TIGR02359   1 IRRLTLLALLIAIGVVLSQLIRIPVgptkAAPVQHFVNVIAGVLLGPWYALAVAFIIGLLRNTLGLGTVLAFPGGMPGAL 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2038652772  84 LAGLFYKYGRKFYFSALGEIVGTGIIGSIVSYPVMVLFTGSAAKLSWFIYTPRFFGATLIGTAISFIAFRFLIKQEFFK 162
Cdd:TIGR02359  81 LAGLLYRFGRKHYWASLGEILGTGIIGSLLAYPVAAWLLGSSENFALFPITLGFIVSTLIGSVIGWFVLVALKRTGVFR 159
ThiW COG4732
ECF-type thiazole transporter, membrane (S) component ThiW [Coenzyme transport and metabolism]; ...
 9-166 2.07e-29

ECF-type thiazole transporter, membrane (S) component ThiW [Coenzyme transport and metabolism];


Pssm-ID: 443766  Cd Length: 165  Bit Score: 105.71  E-value: 2.07e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038652772   9 HKLTILSMMIALDVVLTPIFRIE----GMAPMSSVVNILAGIMMGPVYALAMATVTAFIRMTTQGIPPLALTGATFGALL 84
Cdd:COG4732     5 RKLTLAALLVALGVVLSPLISIPvgpaKAFPVQHAINVLAAVLLGPWYAVGVAFIISLLRNLLGTGSLLAFPGSMIGALL 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038652772  85 AGLFYKYGRKFYFSALGEIVGTGIIGSIVSYPVMVLFTGSAAklSWFIYTPRFFGATLIGTAISFIAFRFLIKQEFFKKV 164
Cdd:COG4732    85 AGLLYRKTKKIWLAALGEVIGTGIIGGLLAYPIAAPLMGKEV--ALFFFVPPFLISSIGGAIIGYLLLKALRRTGLLKRL 162


                  ..
gi 2038652772 165 QG 166
Cdd:COG4732   163 KK 164
 
Name Accession Description Interval E-value
ThiW pfam09512
Thiamine-precursor transporter protein (ThiW); Levels of thiamine pyrophosphate (TPP) or ...
 11-157 2.90e-49

Thiamine-precursor transporter protein (ThiW); Levels of thiamine pyrophosphate (TPP) or thiamine regulate transcription or translation of a number of thiamine biosynthesis, salvage, or transport genes in a wide range of prokaryotes. The mechanism involves direct binding, with no protein involved, to a structural element called THI found in the untranslated upstream region of thiamine metabolism gene operons. This element is called a riboswitch and is seen also for other metabolites such as FMN and glycine. This protein family consists of proteins identified in operons controlled by the THI riboswitch and designated ThiW. The hydrophobic nature of this protein and reconstructed metabolic background suggests that this protein acts in transport of a thiazole precursor of thiamine.


Pssm-ID: 430656  Cd Length: 150  Bit Score: 156.24  E-value: 2.90e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038652772  11 LTILSMMIALDVVLTPIFRI----EGMAPMSSVVNILAGIMMGPVYALAMATVTAFIRMTTQGIPPLALTGATFGALLAG 86
Cdd:pfam09512   1 LTLAAVLIALGVALSPIFSIpvgvAKVFPVQHAINVLAGVLLGPWYALAVALVISLLRNLLGTGTLLAFPGSMFGALLAG 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2038652772  87 LFYKYGRKFYFSALGEIVGTGIIGSIVSYPVMVLFTGSAAKLswFIYTPRFFGATLIGTAISFIAFRFLIK 157
Cdd:pfam09512  81 LLYRYTRKLYLAALGEVLGTGIIGALLAYPVAPLLMGSEAAL--FFFIPPFILSTLIGSVIGYIVLKALKK 149
thiW TIGR02359
energy coupling factor transporter S component ThiW; Levels of thiamine pyrophosphate (TPP) or ...
 8-162 1.08e-40

energy coupling factor transporter S component ThiW; Levels of thiamine pyrophosphate (TPP) or thiamine regulate transcription or translation of a number of thiamine biosynthesis, salvage, or transport genes in a wide range of prokaryotes. The mechanism involves direct binding, with no protein involved,to a structural element called THI found in the untranslated upstream region of thiamine metabolism gene operons. This element is called a riboswitch and is seen also for other metabolites such as FMN and glycine. This protein family consists of proteins identified in operons controlled by the THI riboswitch and designated ThiW. The hydrophobic nature of this protein and reconstructed metabolic background suggests that this protein acts in transport of a thiazole precursor of thiamine. [Transport and binding proteins, Other, Biosynthesis of cofactors, prosthetic groups, and carriers, Thiamine]


Pssm-ID: 131412  Cd Length: 160  Bit Score: 134.45  E-value: 1.08e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038652772   8 VHKLTILSMMIALDVVLTPIFRIEG----MAPMSSVVNILAGIMMGPVYALAMATVTAFIRMTTQGIPPLALTGATFGAL 83
Cdd:TIGR02359   1 IRRLTLLALLIAIGVVLSQLIRIPVgptkAAPVQHFVNVIAGVLLGPWYALAVAFIIGLLRNTLGLGTVLAFPGGMPGAL 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2038652772  84 LAGLFYKYGRKFYFSALGEIVGTGIIGSIVSYPVMVLFTGSAAKLSWFIYTPRFFGATLIGTAISFIAFRFLIKQEFFK 162
Cdd:TIGR02359  81 LAGLLYRFGRKHYWASLGEILGTGIIGSLLAYPVAAWLLGSSENFALFPITLGFIVSTLIGSVIGWFVLVALKRTGVFR 159
ThiW COG4732
ECF-type thiazole transporter, membrane (S) component ThiW [Coenzyme transport and metabolism]; ...
 9-166 2.07e-29

ECF-type thiazole transporter, membrane (S) component ThiW [Coenzyme transport and metabolism];


Pssm-ID: 443766  Cd Length: 165  Bit Score: 105.71  E-value: 2.07e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038652772   9 HKLTILSMMIALDVVLTPIFRIE----GMAPMSSVVNILAGIMMGPVYALAMATVTAFIRMTTQGIPPLALTGATFGALL 84
Cdd:COG4732     5 RKLTLAALLVALGVVLSPLISIPvgpaKAFPVQHAINVLAAVLLGPWYAVGVAFIISLLRNLLGTGSLLAFPGSMIGALL 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038652772  85 AGLFYKYGRKFYFSALGEIVGTGIIGSIVSYPVMVLFTGSAAklSWFIYTPRFFGATLIGTAISFIAFRFLIKQEFFKKV 164
Cdd:COG4732    85 AGLLYRKTKKIWLAALGEVIGTGIIGGLLAYPIAAPLMGKEV--ALFFFVPPFLISSIGGAIIGYLLLKALRRTGLLKRL 162


                  ..
gi 2038652772 165 QG 166
Cdd:COG4732   163 KK 164
SpoIIE COG5817
Stage II sporulation protein SpoIIE/SpoIIH (serine phosphatase - sigma-F activation) [Cell ...
 13-172 7.31e-05

Stage II sporulation protein SpoIIE/SpoIIH (serine phosphatase - sigma-F activation) [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 444519 [Multi-domain]  Cd Length: 803  Bit Score: 42.18  E-value: 7.31e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038652772  13 ILSMMIALDVVLTpifrieGMAPMS----SVVNILA--GIMM-----GPVYALAMATVTAFIRMTTQGIPPLALTGATFG 81
Cdd:COG5817   188 IICLLILLASVLT------GLGGLTigglSLKNILSrlLVLLaayigGAGLGAAVGVVIGLILSLSNGSSPYMIGLYAFA 261

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038652772  82 ALLAGLFYKYGRkfYFSALGEIVGTGIIGsivsypvmvLFTGSAAKLSwfiytprffgATLIGTAISFIAFrFLIKQEFF 161
Cdd:COG5817   262 GLLAGLFREFGK--LGVALGFLLGNLLLT---------LYVSGSGELL----------LSLYEIAIASLLF-LLLPKKLL 319

                         170
                  ....*....|.
gi 2038652772 162 KKVQGYFFAER 172
Cdd:COG5817   320 DKLSRYLPGTS 330
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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