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Conserved domains on  [gi|2039195461|emb|CAG5433526|]
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putative sortase-sorted surface anchored protein (pseudogene) [Streptococcus pneumoniae]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Gram_pos_anchor pfam00746
LPXTG cell wall anchor motif;
131-172 4.22e-09

LPXTG cell wall anchor motif;


:

Pssm-ID: 366278 [Multi-domain]  Cd Length: 43  Bit Score: 49.85  E-value: 4.22e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 2039195461 131 ETGKREELPNTGTEANATLASAGIMTLLASLGLGFFKKKEDE 172
Cdd:pfam00746   2 KKSKKKTLPKTGENSNIFLTAAGLLALLGGLLLLVKRRKKEK 43
Muc_B2 pfam17966
Muc B2-like domain; This entry corresponds to the Muc B2 domain. This domain is related to the ...
 12-73 3.56e-08

Muc B2-like domain; This entry corresponds to the Muc B2 domain. This domain is related to the Muc B1 domain pfam17965. This domain may be involved in mucin binding. This domain is often found associated with the related pfam17965 in bacterial cell surface proteins.


:

Pssm-ID: 465593 [Multi-domain]  Cd Length: 68  Bit Score: 48.04  E-value: 3.56e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2039195461  12 KTITRIIHYVDKvtnQNVKEDVVQPVTLSRTKTENKVTGVVT-YGEWT---TGNWDEVISGKIDKY 73
Cdd:pfam17966   1 KTVTRTIHYVYA---DGAAPDVVQTVTFTRTGTVDLVTGEITsYGDWTadgSTTFAAVDSPVIAGY 63
pullulan_Gpos super family cl37054
pullulanase, extracellular, Gram-positive; Pullulan is an unusual, industrially important ...
 66-170 1.34e-03

pullulanase, extracellular, Gram-positive; Pullulan is an unusual, industrially important polysaccharide in which short alpha-1,4 chains (maltotriose) are connected in alpha-1,6 linkages. Enzymes that cleave alpha-1,6 linkages in pullulan and release maltotriose are called pullulanases although pullulan itself may not be the natural substrate. In contrast, a glycogen debranching enzyme such GlgX, homologous to this family, can release glucose at alpha,1-6 linkages from glycogen first subjected to limit degradation by phosphorylase. Characterized members of this family include a surface-located pullulanase from Streptococcus pneumoniae () and an extracellular bifunctional amylase/pullulanase with C-terminal pullulanase activity (.


The actual alignment was detected with superfamily member TIGR02102:

Pssm-ID: 273973 [Multi-domain]  Cd Length: 1111  Bit Score: 38.30  E-value: 1.34e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2039195461   66 ISGKIDKYKDPDIPTVESQEVTSDSSDKEitvrydrlSTPDKPTPEPGTPKT-ETPV----------NPDPEVPTYETGK 134
Cdd:TIGR02102 1004 VGGIEAPEKTPPPPEHEPQAPKPPTQDPD--------GSKPKDKVDPKDNKDpLTPPgsddengetpKGNEEKKEEQPDK 1075

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 2039195461  135 REELPNTGTEANATLASAGIMTLLASLGLGFFKKKE 170
Cdd:TIGR02102 1076 GANLPNTGTKNSNFILFGGLLVLLGTLGYLLKRKKQ 1111
 
Name Accession Description Interval E-value
Gram_pos_anchor pfam00746
LPXTG cell wall anchor motif;
131-172 4.22e-09

LPXTG cell wall anchor motif;


Pssm-ID: 366278 [Multi-domain]  Cd Length: 43  Bit Score: 49.85  E-value: 4.22e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 2039195461 131 ETGKREELPNTGTEANATLASAGIMTLLASLGLGFFKKKEDE 172
Cdd:pfam00746   2 KKSKKKTLPKTGENSNIFLTAAGLLALLGGLLLLVKRRKKEK 43
Muc_B2 pfam17966
Muc B2-like domain; This entry corresponds to the Muc B2 domain. This domain is related to the ...
 12-73 3.56e-08

Muc B2-like domain; This entry corresponds to the Muc B2 domain. This domain is related to the Muc B1 domain pfam17965. This domain may be involved in mucin binding. This domain is often found associated with the related pfam17965 in bacterial cell surface proteins.


Pssm-ID: 465593 [Multi-domain]  Cd Length: 68  Bit Score: 48.04  E-value: 3.56e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2039195461  12 KTITRIIHYVDKvtnQNVKEDVVQPVTLSRTKTENKVTGVVT-YGEWT---TGNWDEVISGKIDKY 73
Cdd:pfam17966   1 KTVTRTIHYVYA---DGAAPDVVQTVTFTRTGTVDLVTGEITsYGDWTadgSTTFAAVDSPVIAGY 63
LPXTG_anchor TIGR01167
LPXTG-motif cell wall anchor domain; This model describes the LPXTG motif-containing region ...
 137-171 1.57e-05

LPXTG-motif cell wall anchor domain; This model describes the LPXTG motif-containing region found at the C-terminus of many surface proteins of Streptococcus and Streptomyces species. Cleavage between the Thr and Gly by sortase or a related enzyme leads to covalent anchoring at the new C-terminal Thr to the cell wall. Hits that do not lie at the C-terminus or are not found in Gram-positive bacteria are probably false-positive. A common feature of this proteins containing this domain appears to be a high proportion of charged and zwitterionic residues immediatedly upstream of the LPXTG motif. This model differs from other descriptions of the LPXTG region by including a portion of that upstream charged region. [Cell envelope, Other]


Pssm-ID: 273478 [Multi-domain]  Cd Length: 34  Bit Score: 40.15  E-value: 1.57e-05
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 2039195461 137 ELPNTGTEANATLASAGIMtLLASLGLGFFKKKED 171
Cdd:TIGR01167   1 KLPKTGESGNSLLLLLGLL-LLGLGGLLLRKRKKK 34
pullulan_Gpos TIGR02102
pullulanase, extracellular, Gram-positive; Pullulan is an unusual, industrially important ...
 66-170 1.34e-03

pullulanase, extracellular, Gram-positive; Pullulan is an unusual, industrially important polysaccharide in which short alpha-1,4 chains (maltotriose) are connected in alpha-1,6 linkages. Enzymes that cleave alpha-1,6 linkages in pullulan and release maltotriose are called pullulanases although pullulan itself may not be the natural substrate. In contrast, a glycogen debranching enzyme such GlgX, homologous to this family, can release glucose at alpha,1-6 linkages from glycogen first subjected to limit degradation by phosphorylase. Characterized members of this family include a surface-located pullulanase from Streptococcus pneumoniae () and an extracellular bifunctional amylase/pullulanase with C-terminal pullulanase activity (.


Pssm-ID: 273973 [Multi-domain]  Cd Length: 1111  Bit Score: 38.30  E-value: 1.34e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2039195461   66 ISGKIDKYKDPDIPTVESQEVTSDSSDKEitvrydrlSTPDKPTPEPGTPKT-ETPV----------NPDPEVPTYETGK 134
Cdd:TIGR02102 1004 VGGIEAPEKTPPPPEHEPQAPKPPTQDPD--------GSKPKDKVDPKDNKDpLTPPgsddengetpKGNEEKKEEQPDK 1075

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 2039195461  135 REELPNTGTEANATLASAGIMTLLASLGLGFFKKKE 170
Cdd:TIGR02102 1076 GANLPNTGTKNSNFILFGGLLVLLGTLGYLLKRKKQ 1111
Agg_substance NF033875
LPXTG-anchored aggregation substance; Aggregation substances, as described in Enterococcus, ...
 104-170 1.71e-03

LPXTG-anchored aggregation substance; Aggregation substances, as described in Enterococcus, are LPXTG-anchored large surface proteins that contribute to virulence. Several closely related paralogs may be found in a single strain.


Pssm-ID: 411439 [Multi-domain]  Cd Length: 1306  Bit Score: 38.15  E-value: 1.71e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2039195461  104 TPDKPT--PE-----PGTPKT-ETPVNPdpeVPTYETGKREELPNTGTEANATLASAGIMTLLASL-GLGFFKKKE 170
Cdd:NF033875  1232 TPEKPQtpPEktvivPPTPKTpQAPVEP---LVVEKASVVPELPQTGEKQNVLLTVAGSLAAMLGLaGLGFKRRKE 1304
 
Name Accession Description Interval E-value
Gram_pos_anchor pfam00746
LPXTG cell wall anchor motif;
131-172 4.22e-09

LPXTG cell wall anchor motif;


Pssm-ID: 366278 [Multi-domain]  Cd Length: 43  Bit Score: 49.85  E-value: 4.22e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 2039195461 131 ETGKREELPNTGTEANATLASAGIMTLLASLGLGFFKKKEDE 172
Cdd:pfam00746   2 KKSKKKTLPKTGENSNIFLTAAGLLALLGGLLLLVKRRKKEK 43
Muc_B2 pfam17966
Muc B2-like domain; This entry corresponds to the Muc B2 domain. This domain is related to the ...
 12-73 3.56e-08

Muc B2-like domain; This entry corresponds to the Muc B2 domain. This domain is related to the Muc B1 domain pfam17965. This domain may be involved in mucin binding. This domain is often found associated with the related pfam17965 in bacterial cell surface proteins.


Pssm-ID: 465593 [Multi-domain]  Cd Length: 68  Bit Score: 48.04  E-value: 3.56e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2039195461  12 KTITRIIHYVDKvtnQNVKEDVVQPVTLSRTKTENKVTGVVT-YGEWT---TGNWDEVISGKIDKY 73
Cdd:pfam17966   1 KTVTRTIHYVYA---DGAAPDVVQTVTFTRTGTVDLVTGEITsYGDWTadgSTTFAAVDSPVIAGY 63
LPXTG_anchor TIGR01167
LPXTG-motif cell wall anchor domain; This model describes the LPXTG motif-containing region ...
 137-171 1.57e-05

LPXTG-motif cell wall anchor domain; This model describes the LPXTG motif-containing region found at the C-terminus of many surface proteins of Streptococcus and Streptomyces species. Cleavage between the Thr and Gly by sortase or a related enzyme leads to covalent anchoring at the new C-terminal Thr to the cell wall. Hits that do not lie at the C-terminus or are not found in Gram-positive bacteria are probably false-positive. A common feature of this proteins containing this domain appears to be a high proportion of charged and zwitterionic residues immediatedly upstream of the LPXTG motif. This model differs from other descriptions of the LPXTG region by including a portion of that upstream charged region. [Cell envelope, Other]


Pssm-ID: 273478 [Multi-domain]  Cd Length: 34  Bit Score: 40.15  E-value: 1.57e-05
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 2039195461 137 ELPNTGTEANATLASAGIMtLLASLGLGFFKKKED 171
Cdd:TIGR01167   1 KLPKTGESGNSLLLLLGLL-LLGLGGLLLRKRKKK 34
pullulan_Gpos TIGR02102
pullulanase, extracellular, Gram-positive; Pullulan is an unusual, industrially important ...
 66-170 1.34e-03

pullulanase, extracellular, Gram-positive; Pullulan is an unusual, industrially important polysaccharide in which short alpha-1,4 chains (maltotriose) are connected in alpha-1,6 linkages. Enzymes that cleave alpha-1,6 linkages in pullulan and release maltotriose are called pullulanases although pullulan itself may not be the natural substrate. In contrast, a glycogen debranching enzyme such GlgX, homologous to this family, can release glucose at alpha,1-6 linkages from glycogen first subjected to limit degradation by phosphorylase. Characterized members of this family include a surface-located pullulanase from Streptococcus pneumoniae () and an extracellular bifunctional amylase/pullulanase with C-terminal pullulanase activity (.


Pssm-ID: 273973 [Multi-domain]  Cd Length: 1111  Bit Score: 38.30  E-value: 1.34e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2039195461   66 ISGKIDKYKDPDIPTVESQEVTSDSSDKEitvrydrlSTPDKPTPEPGTPKT-ETPV----------NPDPEVPTYETGK 134
Cdd:TIGR02102 1004 VGGIEAPEKTPPPPEHEPQAPKPPTQDPD--------GSKPKDKVDPKDNKDpLTPPgsddengetpKGNEEKKEEQPDK 1075

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 2039195461  135 REELPNTGTEANATLASAGIMTLLASLGLGFFKKKE 170
Cdd:TIGR02102 1076 GANLPNTGTKNSNFILFGGLLVLLGTLGYLLKRKKQ 1111
Agg_substance NF033875
LPXTG-anchored aggregation substance; Aggregation substances, as described in Enterococcus, ...
 104-170 1.71e-03

LPXTG-anchored aggregation substance; Aggregation substances, as described in Enterococcus, are LPXTG-anchored large surface proteins that contribute to virulence. Several closely related paralogs may be found in a single strain.


Pssm-ID: 411439 [Multi-domain]  Cd Length: 1306  Bit Score: 38.15  E-value: 1.71e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2039195461  104 TPDKPT--PE-----PGTPKT-ETPVNPdpeVPTYETGKREELPNTGTEANATLASAGIMTLLASL-GLGFFKKKE 170
Cdd:NF033875  1232 TPEKPQtpPEktvivPPTPKTpQAPVEP---LVVEKASVVPELPQTGEKQNVLLTVAGSLAAMLGLaGLGFKRRKE 1304
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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