|
Name |
Accession |
Description |
Interval |
E-value |
| PRK14022 |
PRK14022 |
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase; |
2-481 |
0e+00 |
|
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase;
Pssm-ID: 237588 [Multi-domain] Cd Length: 481 Bit Score: 923.28 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038730098 2 IKIETVLDILKKDGLFREIIDQGHYHYNYSKVVFDSISYDSRKVTEDTLFFAKGAAFKKEYLLSAITQGLAWYVAEKDYE 81
Cdd:PRK14022 1 ITIETLLDILKKDHNFREIIDQDHYHYNYSGVQFDDISYDSRTADEGTLFFAKGAYFKHKFLQNAITQGLKLYVSEKDYE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038730098 82 VGIPVIIVNDIKKAMSLIAMEFYGNPQEKLKLLAFTGTKGKTTAAYFAYNILSQGHRPAMLSTMNTTLDGETFFKSALTT 161
Cdd:PRK14022 81 VGIPQVIVPDIKKAMSLIAMEFYDNPQHKLKLLAFTGTKGKTTAAYFAYHILKQLHKPAMLSTMNTTLDGETFFKSALTT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038730098 162 PESIDLFDMMNQAVQNDRTHLIMEVSSQSYLVRRVYGLTFDVGVFLNISPDHIGPIEHPSFEDYFYHKRLLMENSRAVII 241
Cdd:PRK14022 161 PESLDLFKMMAEAVDNGMTHLIMEVSSQAYLVGRVYGLTFDVGVFLNITPDHIGPIEHPTFEDYFYHKRLLMENSKAVVV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038730098 242 NSDMDHFSVLKEQVEDQDHDFYGSQFDNQIENSKAFSFSATGKLAGDYDIQLIGNFNQENAVAAGLACLRLGASLEDIKK 321
Cdd:PRK14022 241 NSDMDHFSELLEQVTPQEHDFYGIDSENQIMASNAFSFEATGKLAGTYDIQLIGKFNQENAMAAGLACLRLGASLEDIQK 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038730098 322 GIAATRVPGRMEVLTQKNGAKVFIDYAHNGDSLKKLINVVETHQTGKIALVLGSTGNKGESRRKDFGLLLNQHPEIQVFL 401
Cdd:PRK14022 321 GIAQTPVPGRMEVLTQSNGAKVFIDYAHNGDSLNKLIDVVEEHQKGKLILLLGAAGNKGESRRPDFGRVANRHPYLQVIL 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038730098 402 TADDPNYEDPMAIADEISSYINHPVEKIADRQEAIKAAMAITNHELDAVIIAGKGADCYQIIQGKKESYPGDTAVAENYL 481
Cdd:PRK14022 401 TADDPNNEDPKMITQEIASHITHPVEIIDDRAEAIKHAMSITEGPGDAVIIAGKGADAYQIVPGHRDDYIGDEAAAKKYL 480
|
|
| MurE |
COG0769 |
UDP-N-acetylmuramyl tripeptide synthase [Cell wall/membrane/envelope biogenesis]; ... |
37-481 |
1.30e-136 |
|
UDP-N-acetylmuramyl tripeptide synthase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramyl tripeptide synthase is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440532 [Multi-domain] Cd Length: 459 Bit Score: 401.38 E-value: 1.30e-136
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038730098 37 SISYDSRKVTEDTLFFA-KGAAFK-KEYLLSAITQGLAWYVAEKDYEV---GIPVIIVNDIKKAMSLIAMEFYGNPQEKL 111
Cdd:COG0769 1 GITYDSRKVKPGDLFVAlPGARVDgHDFIAQAIARGAVAVVTEAPGALlaaGVPVIVVPDPRAALALLAAAFYGHPSQKL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038730098 112 KLLAFTGTKGKTTAAYFAYNILSQ-GHRPAMLSTMNTTLDGETFfKSALTTPESIDLFDMMNQAVQNDRTHLIMEVSSQS 190
Cdd:COG0769 81 KLIGVTGTNGKTTTTYLLAQILRAlGKKTGLIGTVGNGIGGELI-PSSLTTPEALDLQRLLAEMVDAGVTHVVMEVSSHA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038730098 191 YLVRRVYGLTFDVGVFLNISPDHIgpIEHPSFEDYFYHKRLLMEN---SRAVIINSDMDHFSVLKEQVE--------DQD 259
Cdd:COG0769 160 LDQGRVDGVRFDVAVFTNLTRDHL--DYHGTMEAYFAAKARLFDQlgpGGAAVINADDPYGRRLAAAAParvityglKAD 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038730098 260 HDFYGSQFDNQIENSKaFSFSATGKlAGDYDIQLIGNFNQENAVAAGLACLRLGASLEDIKKGIAA-TRVPGRMEVLTQK 338
Cdd:COG0769 238 ADLRATDIELSADGTR-FTLVTPGG-EVEVRLPLIGRFNVYNALAAIAAALALGIDLEEILAALEKlKGVPGRMERVDGG 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038730098 339 NGAKVFIDYAHNGDSLKKLINVVETHQTGKIALVLGSTGNKGESRRKDFGlllnqhpEI------QVFLTADDPNYEDPM 412
Cdd:COG0769 316 QGPTVIVDYAHTPDALENVLEALRPHTKGRLIVVFGCGGDRDRGKRPLMG-------EIaarladVVIVTSDNPRSEDPA 388
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2038730098 413 AIADEISSYINHP--VEKIADRQEAIKAAMAITNhELDAVIIAGKGADCYQIIQGKKESYPgDTAVAENYL 481
Cdd:COG0769 389 AIIADILAGIPGAgkVLVIPDRAEAIRYAIALAK-PGDVVLIAGKGHETYQIIGGVKIPFD-DREVAREAL 457
|
|
| murE |
TIGR01085 |
UDP-N-acetylmuramyl-tripeptide synthetase; Most members of this family are EC 6.3.2.13, ... |
37-467 |
3.91e-79 |
|
UDP-N-acetylmuramyl-tripeptide synthetase; Most members of this family are EC 6.3.2.13, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase. An exception is Staphylococcus aureus, in which diaminopimelate is replaced by lysine in the peptidoglycan and MurE is EC 6.3.2.7. The Mycobacteria, part of the closest neighboring branch outside of the low-GC Gram-positive bacteria, use diaminopimelate. A close homolog, scoring just below the trusted cutoff, is found (with introns) in Arabidopsis thaliana. Its role is unknown. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273435 [Multi-domain] Cd Length: 464 Bit Score: 253.78 E-value: 3.91e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038730098 37 SISYDSRKVTEDTLFFA-KGAAFK-KEYLLSAITQGLAWYVAEKD---YEVGIPVIIVNDIKKAMSLIAMEFYGNPQEKL 111
Cdd:TIGR01085 6 GLTLDSREVKPGDLFVAiKGTHVDgHDFIHDAIANGAVAVVVERDvdfYVAPVPVIIVPDLRHALSSLAAAFYGHPSKKL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038730098 112 KLLAFTGTKGKTTAAYFAYNIL-SQGHRPAMLSTMNTTLDGET--FFKSALTTPESIDLFDMMNQAVQNDRTHLIMEVSS 188
Cdd:TIGR01085 86 KVIGVTGTNGKTTTTSLIAQLLrLLGKKTGLIGTIGYRLGGNDliKNPAALTTPEALTLQSTLAEMVEAGAQYAVMEVSS 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038730098 189 QSYLVRRVYGLTFDVGVFLNISPDHIGpiEHPSFEDYFYHKRLLME----NSRAVIINSDM----------DHFSVLKEQ 254
Cdd:TIGR01085 166 HALAQGRVRGVRFDAAVFTNLSRDHLD--FHGTMENYFAAKASLFTelglKRFAVINLDDEygaqfvkrlpKDITVSAIT 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038730098 255 VE-----------DQDHDFYGSQFDnqIENSkafsfsatgklAGDYDIQ--LIGNFNQENAVAAGLACLRLG-ASLEDIK 320
Cdd:TIGR01085 244 QPadgraqdikitDSGYSFEGQQFT--FETP-----------AGEGHLHtpLIGRFNVYNLLAALATLLHLGgIDLEDIV 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038730098 321 KGIAATR-VPGRMEVLTQKNGAKVFIDYAHNGDSLKKLINVVETHQTGKIALVLGSTGNKGESRRKDFGLLLNQHPEIqV 399
Cdd:TIGR01085 311 AALEKFRgVPGRMELVDGGQKFLVIVDYAHTPDALEKALRTLRKHKDGRLIVVFGCGGDRDRGKRPLMGAIAEQLADL-V 389
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038730098 400 FLTADDPNYEDPMAIADEISSYINHP--VEKIADRQEAIKAAMAITNhELDAVIIAGKGADCYQIIQGKK 467
Cdd:TIGR01085 390 ILTSDNPRGEDPEQIIADILAGISEKekVVIIADRRQAIRYAISNAK-AGDVVLIAGKGHEDYQIIGGET 458
|
|
| Mur_ligase_M |
pfam08245 |
Mur ligase middle domain; |
117-309 |
5.29e-33 |
|
Mur ligase middle domain;
Pssm-ID: 462409 [Multi-domain] Cd Length: 199 Bit Score: 123.95 E-value: 5.29e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038730098 117 TGTKGKTTAAYFAYNILSQghRPAMLSTMnttldGETFFKSALTTPESIDLFDMMNQAVQNDRTHLIMEVSSQSYLVRRV 196
Cdd:pfam08245 2 TGTNGKTTTTELIAAILSL--AGGVIGTI-----GTYIGKSGNTTNNAIGLPLTLAEMVEAGAEYAVLEVSSHGLGEGRL 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038730098 197 YGLT-FDVGVFLNISPDHIGpiEHPSFEDYFYHKRLLMENSRA---VIINSDMDHFSVLKEQVEDQDHD--FYG--SQFD 268
Cdd:pfam08245 75 SGLLkPDIAVFTNISPDHLD--FHGTMENYAKAKAELFEGLPEdgiAVINADDPYGAFLIAKLKKAGVRviTYGieGEAD 152
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 2038730098 269 NQIENSKAFSFSATGKLAG------DYDIQLIGNFNQENAVAAGLAC 309
Cdd:pfam08245 153 LRAANIELSSDGTSFDLFTvpggelEIEIPLLGRHNVYNALAAIAAA 199
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK14022 |
PRK14022 |
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase; |
2-481 |
0e+00 |
|
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase;
Pssm-ID: 237588 [Multi-domain] Cd Length: 481 Bit Score: 923.28 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038730098 2 IKIETVLDILKKDGLFREIIDQGHYHYNYSKVVFDSISYDSRKVTEDTLFFAKGAAFKKEYLLSAITQGLAWYVAEKDYE 81
Cdd:PRK14022 1 ITIETLLDILKKDHNFREIIDQDHYHYNYSGVQFDDISYDSRTADEGTLFFAKGAYFKHKFLQNAITQGLKLYVSEKDYE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038730098 82 VGIPVIIVNDIKKAMSLIAMEFYGNPQEKLKLLAFTGTKGKTTAAYFAYNILSQGHRPAMLSTMNTTLDGETFFKSALTT 161
Cdd:PRK14022 81 VGIPQVIVPDIKKAMSLIAMEFYDNPQHKLKLLAFTGTKGKTTAAYFAYHILKQLHKPAMLSTMNTTLDGETFFKSALTT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038730098 162 PESIDLFDMMNQAVQNDRTHLIMEVSSQSYLVRRVYGLTFDVGVFLNISPDHIGPIEHPSFEDYFYHKRLLMENSRAVII 241
Cdd:PRK14022 161 PESLDLFKMMAEAVDNGMTHLIMEVSSQAYLVGRVYGLTFDVGVFLNITPDHIGPIEHPTFEDYFYHKRLLMENSKAVVV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038730098 242 NSDMDHFSVLKEQVEDQDHDFYGSQFDNQIENSKAFSFSATGKLAGDYDIQLIGNFNQENAVAAGLACLRLGASLEDIKK 321
Cdd:PRK14022 241 NSDMDHFSELLEQVTPQEHDFYGIDSENQIMASNAFSFEATGKLAGTYDIQLIGKFNQENAMAAGLACLRLGASLEDIQK 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038730098 322 GIAATRVPGRMEVLTQKNGAKVFIDYAHNGDSLKKLINVVETHQTGKIALVLGSTGNKGESRRKDFGLLLNQHPEIQVFL 401
Cdd:PRK14022 321 GIAQTPVPGRMEVLTQSNGAKVFIDYAHNGDSLNKLIDVVEEHQKGKLILLLGAAGNKGESRRPDFGRVANRHPYLQVIL 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038730098 402 TADDPNYEDPMAIADEISSYINHPVEKIADRQEAIKAAMAITNHELDAVIIAGKGADCYQIIQGKKESYPGDTAVAENYL 481
Cdd:PRK14022 401 TADDPNNEDPKMITQEIASHITHPVEIIDDRAEAIKHAMSITEGPGDAVIIAGKGADAYQIVPGHRDDYIGDEAAAKKYL 480
|
|
| murE |
PRK00139 |
UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase; Provisional |
31-481 |
1.76e-150 |
|
UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase; Provisional
Pssm-ID: 234660 [Multi-domain] Cd Length: 460 Bit Score: 436.87 E-value: 1.76e-150
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038730098 31 SKVVFDSISYDSRKVTEDTLFFAKGAAFKK--EYLLSAITQGLAWYVAEKDYE--VGIPVIIVNDIKKAMSLIAMEFYGN 106
Cdd:PRK00139 11 APVEITGLTYDSRKVKPGDLFVALPGHKVDgrDFIAQAIANGAAAVVAEADGEagTGVPVIIVPDLRKALALLAAAFYGH 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038730098 107 PQEKLKLLAFTGTKGKTTAAYFAYNILSQ-GHRPAMLSTMNTTLDGETFfKSALTTPESIDLFDMMNQAVQNDRTHLIME 185
Cdd:PRK00139 91 PSDKLKLIGVTGTNGKTTTAYLLAQILRLlGEKTALIGTLGNGIGGELI-PSGLTTPDALDLQRLLAELVDAGVTYAAME 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038730098 186 VSSQSYLVRRVYGLTFDVGVFLNISPDHIGpiEHPSFEDYFYHKRLLMEN-SRAVIINSDMDHFSVLKEQ-----VEDQD 259
Cdd:PRK00139 170 VSSHALDQGRVDGLKFDVAVFTNLSRDHLD--YHGTMEDYLAAKARLFSElGLAAVINADDEVGRRLLALpdayaVSMAG 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038730098 260 HDFYGsqfdnqiensKAFSFSATG---KLAGDYDIQLIGNFNQENAVAAGLACLRLGASLEDIKKGIAA-TRVPGRMEVL 335
Cdd:PRK00139 248 ADLRA----------TDVEYTDSGqtfTLVTEVESPLIGRFNVSNLLAALAALLALGVPLEDALAALAKlQGVPGRMERV 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038730098 336 TQKNGAKVFIDYAHNGDSLKKLINVVETHQTGKIALVLGSTGNKGESRRKDFGLLLNQHPEIqVFLTADDPNYEDPMAIA 415
Cdd:PRK00139 318 DAGQGPLVIVDYAHTPDALEKVLEALRPHAKGRLICVFGCGGDRDKGKRPLMGAIAERLADV-VIVTSDNPRSEDPAAII 396
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2038730098 416 DEISSYInhpVEKIADRQEAIKAAMAITNHElDAVIIAGKGADCYQIIQGKKESYPgDTAVAENYL 481
Cdd:PRK00139 397 ADILAGI---YDVIEDRAEAIRYAIAQAKPG-DVVLIAGKGHEDYQIIGGVKIPFD-DREVAREAL 457
|
|
| MurE |
COG0769 |
UDP-N-acetylmuramyl tripeptide synthase [Cell wall/membrane/envelope biogenesis]; ... |
37-481 |
1.30e-136 |
|
UDP-N-acetylmuramyl tripeptide synthase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramyl tripeptide synthase is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440532 [Multi-domain] Cd Length: 459 Bit Score: 401.38 E-value: 1.30e-136
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038730098 37 SISYDSRKVTEDTLFFA-KGAAFK-KEYLLSAITQGLAWYVAEKDYEV---GIPVIIVNDIKKAMSLIAMEFYGNPQEKL 111
Cdd:COG0769 1 GITYDSRKVKPGDLFVAlPGARVDgHDFIAQAIARGAVAVVTEAPGALlaaGVPVIVVPDPRAALALLAAAFYGHPSQKL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038730098 112 KLLAFTGTKGKTTAAYFAYNILSQ-GHRPAMLSTMNTTLDGETFfKSALTTPESIDLFDMMNQAVQNDRTHLIMEVSSQS 190
Cdd:COG0769 81 KLIGVTGTNGKTTTTYLLAQILRAlGKKTGLIGTVGNGIGGELI-PSSLTTPEALDLQRLLAEMVDAGVTHVVMEVSSHA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038730098 191 YLVRRVYGLTFDVGVFLNISPDHIgpIEHPSFEDYFYHKRLLMEN---SRAVIINSDMDHFSVLKEQVE--------DQD 259
Cdd:COG0769 160 LDQGRVDGVRFDVAVFTNLTRDHL--DYHGTMEAYFAAKARLFDQlgpGGAAVINADDPYGRRLAAAAParvityglKAD 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038730098 260 HDFYGSQFDNQIENSKaFSFSATGKlAGDYDIQLIGNFNQENAVAAGLACLRLGASLEDIKKGIAA-TRVPGRMEVLTQK 338
Cdd:COG0769 238 ADLRATDIELSADGTR-FTLVTPGG-EVEVRLPLIGRFNVYNALAAIAAALALGIDLEEILAALEKlKGVPGRMERVDGG 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038730098 339 NGAKVFIDYAHNGDSLKKLINVVETHQTGKIALVLGSTGNKGESRRKDFGlllnqhpEI------QVFLTADDPNYEDPM 412
Cdd:COG0769 316 QGPTVIVDYAHTPDALENVLEALRPHTKGRLIVVFGCGGDRDRGKRPLMG-------EIaarladVVIVTSDNPRSEDPA 388
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2038730098 413 AIADEISSYINHP--VEKIADRQEAIKAAMAITNhELDAVIIAGKGADCYQIIQGKKESYPgDTAVAENYL 481
Cdd:COG0769 389 AIIADILAGIPGAgkVLVIPDRAEAIRYAIALAK-PGDVVLIAGKGHETYQIIGGVKIPFD-DREVAREAL 457
|
|
| murE |
TIGR01085 |
UDP-N-acetylmuramyl-tripeptide synthetase; Most members of this family are EC 6.3.2.13, ... |
37-467 |
3.91e-79 |
|
UDP-N-acetylmuramyl-tripeptide synthetase; Most members of this family are EC 6.3.2.13, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase. An exception is Staphylococcus aureus, in which diaminopimelate is replaced by lysine in the peptidoglycan and MurE is EC 6.3.2.7. The Mycobacteria, part of the closest neighboring branch outside of the low-GC Gram-positive bacteria, use diaminopimelate. A close homolog, scoring just below the trusted cutoff, is found (with introns) in Arabidopsis thaliana. Its role is unknown. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273435 [Multi-domain] Cd Length: 464 Bit Score: 253.78 E-value: 3.91e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038730098 37 SISYDSRKVTEDTLFFA-KGAAFK-KEYLLSAITQGLAWYVAEKD---YEVGIPVIIVNDIKKAMSLIAMEFYGNPQEKL 111
Cdd:TIGR01085 6 GLTLDSREVKPGDLFVAiKGTHVDgHDFIHDAIANGAVAVVVERDvdfYVAPVPVIIVPDLRHALSSLAAAFYGHPSKKL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038730098 112 KLLAFTGTKGKTTAAYFAYNIL-SQGHRPAMLSTMNTTLDGET--FFKSALTTPESIDLFDMMNQAVQNDRTHLIMEVSS 188
Cdd:TIGR01085 86 KVIGVTGTNGKTTTTSLIAQLLrLLGKKTGLIGTIGYRLGGNDliKNPAALTTPEALTLQSTLAEMVEAGAQYAVMEVSS 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038730098 189 QSYLVRRVYGLTFDVGVFLNISPDHIGpiEHPSFEDYFYHKRLLME----NSRAVIINSDM----------DHFSVLKEQ 254
Cdd:TIGR01085 166 HALAQGRVRGVRFDAAVFTNLSRDHLD--FHGTMENYFAAKASLFTelglKRFAVINLDDEygaqfvkrlpKDITVSAIT 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038730098 255 VE-----------DQDHDFYGSQFDnqIENSkafsfsatgklAGDYDIQ--LIGNFNQENAVAAGLACLRLG-ASLEDIK 320
Cdd:TIGR01085 244 QPadgraqdikitDSGYSFEGQQFT--FETP-----------AGEGHLHtpLIGRFNVYNLLAALATLLHLGgIDLEDIV 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038730098 321 KGIAATR-VPGRMEVLTQKNGAKVFIDYAHNGDSLKKLINVVETHQTGKIALVLGSTGNKGESRRKDFGLLLNQHPEIqV 399
Cdd:TIGR01085 311 AALEKFRgVPGRMELVDGGQKFLVIVDYAHTPDALEKALRTLRKHKDGRLIVVFGCGGDRDRGKRPLMGAIAEQLADL-V 389
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038730098 400 FLTADDPNYEDPMAIADEISSYINHP--VEKIADRQEAIKAAMAITNhELDAVIIAGKGADCYQIIQGKK 467
Cdd:TIGR01085 390 ILTSDNPRGEDPEQIIADILAGISEKekVVIIADRRQAIRYAISNAK-AGDVVLIAGKGHEDYQIIGGET 458
|
|
| PRK11929 |
PRK11929 |
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE ... |
41-467 |
1.54e-66 |
|
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE/UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase MurF;
Pssm-ID: 237025 [Multi-domain] Cd Length: 958 Bit Score: 230.36 E-value: 1.54e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038730098 41 DSRKVTEDTLFFA-KGAAFK-KEYLLSAITQGLAWYVAEKDYEVGIP-----VIIVNDIKKAMSLIAMEFYGNPQEKLKL 113
Cdd:PRK11929 35 DSREVQPGDLFVAcRGAASDgRAFIDQALARGAAAVLVEAEGEDQVAaadalVLPVADLRKALGELAARWYGRPSEQLSL 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038730098 114 LAFTGTKGKTTAAYFAYNILSQ-GHRPAMLSTMNTTLDGETfFKSALTTPESIDLFDMMNQAVQNDRTHLIMEVSSQSYL 192
Cdd:PRK11929 115 VAVTGTNGKTSCAQLLAQLLTRlGKPCGSIGTLGARLDGRL-IPGSLTTPDAIILHRILARMRAAGADAVAMEASSHGLE 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038730098 193 VRRVYGLTFDVGVFLNISPDHIGpiEHPSFEDYFYHKRLLMEN---SRAVIINSDMDHFSVLKEQVEdqdhdfYGSQFDN 269
Cdd:PRK11929 194 QGRLDGLRIAVAGFTNLTRDHLD--YHGTMQDYEEAKAALFSKlpgLGAAVINADDPAAARLLAALP------RGLKVGY 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038730098 270 QIENSKAFSFS------ATGKLA------GDYDIQ--LIGNFNQENAVAAGLACLRLGASLEDIKKGIAATR-VPGRMEV 334
Cdd:PRK11929 266 SPQNAGADVQArdlratAHGQVFtlatpdGSYQLVtrLLGRFNVSNLLLVAAALKKLGLPLAQIARALAAVSpVPGRMER 345
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038730098 335 LTQ---KNGAKVFIDYAHNGDSLKKLINV---VETHQTGKIALVLGSTGNKGESRRKDFGLLLNQHPEiQVFLTADDPNY 408
Cdd:PRK11929 346 VGPtagAQGPLVVVDYAHTPDALAKALTAlrpVAQARNGRLVCVFGCGGDRDKGKRPEMGRIAAELAD-RVVVTSDNPRS 424
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2038730098 409 EDPMAIADEISSYINHP--VEKIADRQEAIKAA--MAITNhelDAVIIAGKGADCYQIIQGKK 467
Cdd:PRK11929 425 EAPEAIIDQILAGIPAGarVFVISDRAEAIRQAiwMAAPG---DVILIAGKGHETYQEIGGRK 484
|
|
| Mur_ligase_M |
pfam08245 |
Mur ligase middle domain; |
117-309 |
5.29e-33 |
|
Mur ligase middle domain;
Pssm-ID: 462409 [Multi-domain] Cd Length: 199 Bit Score: 123.95 E-value: 5.29e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038730098 117 TGTKGKTTAAYFAYNILSQghRPAMLSTMnttldGETFFKSALTTPESIDLFDMMNQAVQNDRTHLIMEVSSQSYLVRRV 196
Cdd:pfam08245 2 TGTNGKTTTTELIAAILSL--AGGVIGTI-----GTYIGKSGNTTNNAIGLPLTLAEMVEAGAEYAVLEVSSHGLGEGRL 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038730098 197 YGLT-FDVGVFLNISPDHIGpiEHPSFEDYFYHKRLLMENSRA---VIINSDMDHFSVLKEQVEDQDHD--FYG--SQFD 268
Cdd:pfam08245 75 SGLLkPDIAVFTNISPDHLD--FHGTMENYAKAKAELFEGLPEdgiAVINADDPYGAFLIAKLKKAGVRviTYGieGEAD 152
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 2038730098 269 NQIENSKAFSFSATGKLAG------DYDIQLIGNFNQENAVAAGLAC 309
Cdd:pfam08245 153 LRAANIELSSDGTSFDLFTvpggelEIEIPLLGRHNVYNALAAIAAA 199
|
|
| murF |
TIGR01143 |
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; This family consists of the ... |
41-381 |
3.68e-26 |
|
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; This family consists of the strictly bacterial MurF gene of peptidoglycan biosynthesis. This enzyme is almost always UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanyl ligase, but in a few species, MurE adds lysine rather than diaminopimelate. This enzyme acts on the product from MurE activity, and so is also subfamily rather than equivalog. Staphylococcus aureus is an example of species in this MurF protein would differ. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273468 [Multi-domain] Cd Length: 417 Bit Score: 110.05 E-value: 3.68e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038730098 41 DSRKVTEDTLFFA-KGAAFK-KEYLLSAITQGLAWYVAEKDYEV--GIPVIIVNDIKKAMSLIAmEFYGNpQEKLKLLAF 116
Cdd:TIGR01143 2 DSRAIKPGDLFIAlKGERFDgHDFVEQALAAGAVAVVVDREVGPdnGLPQILVDDTLEALQALA-RAKRA-KFSGKVIGI 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038730098 117 TGTKGKTTAAYFAYNILSQghrpamlstmnttlDGETF-----FKSALTTPESIdlfdmmnQAVQNDRTHLIME--VSSQ 189
Cdd:TIGR01143 80 TGSSGKTTTKEMLAAILSH--------------KYKVFatpgnFNNEIGLPLTL-------LRAPGDHDYAVLEmgASHP 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038730098 190 ---SYLVRRVyglTFDVGVFLNISPDHIGpiEHPSFEDYFYHKRLLMENSRA---VIINSDMDHFSVLKEQVED------ 257
Cdd:TIGR01143 139 geiAYLAEIA---KPDIAVITNIGPAHLE--GFGSLEGIAEAKGEILQGLKEngiAVINADDPAFADLAKRLPNrnilsf 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038730098 258 --QDHDFYGSQFDNQIENSKAFSFSATGKLAgDYDIQLIGNFNQENAVAAGLACLRLGASLEDIKKGIAATR-VPGRMEV 334
Cdd:TIGR01143 214 gfEGGDFVAKDISYSALGSTSFTLVAPGGEF-EVSLPLLGRHNVMNALAAAALALELGIPLEEIAEGLAELKlVKGRFEV 292
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 2038730098 335 LTQKNgaKVFIDYAHNG--DSLKKLINVVEtHQTGKIALVLGSTGNKGE 381
Cdd:TIGR01143 293 QTKNG--LTLIDDTYNAnpDSMRAALDALA-RFPGKKILVLGDMAELGE 338
|
|
| MurF |
COG0770 |
UDP-N-acetylmuramyl pentapeptide synthase [Cell wall/membrane/envelope biogenesis]; ... |
33-374 |
1.62e-24 |
|
UDP-N-acetylmuramyl pentapeptide synthase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramyl pentapeptide synthase is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440533 [Multi-domain] Cd Length: 451 Bit Score: 105.57 E-value: 1.62e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038730098 33 VVFDSISYDSRKVTEDTLFFA-KGAAFKK-EYLLSAITQGLAWYVAEKDYEVGIPVIIVNDIKKAMSLIAmEFYGNpQEK 110
Cdd:COG0770 22 LVVTGVSTDSRKIKPGDLFVAlKGERFDGhDFVAQALAKGAAAALVSRPLPADLPLIVVDDTLKALQQLA-AAHRA-RFN 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038730098 111 LKLLAFTGTKGKTT-----AAyfaynILSQghrpamlstmnttlDGETFfKSA----------LTtpesidLFDMmnqav 175
Cdd:COG0770 100 IPVIAITGSNGKTTtkemlAA-----VLST--------------KGKVL-ATPgnfnneigvpLT------LLRL----- 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038730098 176 qnDRTH--LIMEV--SSQ---SYLVRrvygLTF-DVGVFLNISPDHIGpiEHPSFEDYFYHKRLLMENSRA---VIINSD 244
Cdd:COG0770 149 --PEDHefAVLEMgmNHPgeiAYLAR----IARpDIAVITNIGPAHLE--GFGSLEGIARAKGEIFEGLPPggvAVLNAD 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038730098 245 MDHFSVLKEQV--------EDQDHDFYGSQFDNQIENSKaFSFSATGKLAgDYDIQLIGNFNQENAVAAGLACLRLGASL 316
Cdd:COG0770 221 DPLLAALAERAkarvltfgLSEDADVRAEDIELDEDGTR-FTLHTPGGEL-EVTLPLPGRHNVSNALAAAAVALALGLDL 298
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2038730098 317 EDIKKGIAA-TRVPGRMEVLTQKNGAKVfIDYAHNG--DSLKKLINV-VETHQTGKIALVLG 374
Cdd:COG0770 299 EEIAAGLAAfQPVKGRLEVIEGAGGVTL-IDDSYNAnpDSMKAALDVlAQLPGGGRRIAVLG 359
|
|
| murD |
TIGR01087 |
UDP-N-acetylmuramoylalanine--D-glutamate ligase; [Cell envelope, Biosynthesis and degradation ... |
110-444 |
1.23e-20 |
|
UDP-N-acetylmuramoylalanine--D-glutamate ligase; [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273436 [Multi-domain] Cd Length: 433 Bit Score: 93.94 E-value: 1.23e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038730098 110 KLKLLAFTGTKGKTTAAYFAYNILSQGHRPAMLstmnttldGETFFKSALttpesiDLFDmmnqavQNDRTHLIMEVSsq 189
Cdd:TIGR01087 101 PLPVVAITGTNGKTTTTSLLYHLLKAAGLKAFL--------GGNIGTPAL------EVLD------QEGAELYVLELS-- 158
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038730098 190 SYLVRRVYGLTFDVGVFLNISPDHIGpiEHPSFEDYFYHK-RLL--MENSRAVIINSDMDHFSVLKEQVEDQDHDFYGS- 265
Cdd:TIGR01087 159 SFQLETTESLRPEIALILNISEDHLD--WHGSFEDYVAAKlKIFarQTEGDVAVLNADDPRFARLAQKSKAQVIWFSVEk 236
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038730098 266 --QFDNQIENSKAFSFSAtgklagDYDIQLIGNFNQENAVAAGLACLRLGASLEDIKKGIAA-TRVPGRMEVLTQKNGAK 342
Cdd:TIGR01087 237 daERGLCIRDGGLYLKPN------DLEGSLLGLHNAENILAAIALAKSLGLNLEAILEALRSfKGLPHRLEYVGQKNGVH 310
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038730098 343 vFIDyahngDSlkKLINVVETHQT-----GKIALVLGSTGnKGEsrrkDFGLL---LNQHPeIQVFLTAddpnyEDPMAI 414
Cdd:TIGR01087 311 -FYN-----DS--KATNVHATLAAlsafdNPVILIVGGDD-KGA----DFSPLapaAAGKV-KAVLAIG-----EDAAKI 371
|
330 340 350
....*....|....*....|....*....|
gi 2038730098 415 ADeISSYINHPVEKIADRQEAIKAAMAITN 444
Cdd:TIGR01087 372 AP-LLKEAGLSVYLVESLEEAVQAAREVAS 400
|
|
| MurD |
COG0771 |
UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; ... |
112-353 |
3.48e-19 |
|
UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramoylalanine-D-glutamate ligase is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440534 [Multi-domain] Cd Length: 445 Bit Score: 89.75 E-value: 3.48e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038730098 112 KLLAFTGTKGKTTaayfaynilsqghrpamlsTmnTTLDGEtFFKSA---------LTTPesidLFDMMNQAVQNDrtHL 182
Cdd:COG0771 106 PIIAITGTNGKTT-------------------T--TTLIGH-ILKAAglrvavggnIGTP----LLDLLLEPEPPD--VY 157
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038730098 183 IMEVSS-QsyLvRRVYGLTFDVGVFLNISPDHigpIE-HPSFEDYFYHKRLLMENSRA---VIINSDmdhfsvlkeqved 257
Cdd:COG0771 158 VLELSSfQ--L-ETTPSLRPDVAVILNITPDH---LDrHGSMEAYAAAKARIFANQTPddyAVLNAD------------- 218
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038730098 258 qdhDFYGSQFDNQIeNSKAFSFSATGKLAGDY--------------------DIQLIGNFNQENAVAAGLACLRLGASLE 317
Cdd:COG0771 219 ---DPLTRALAEEA-KARVVPFSLKEPLEGGAgledgklvdrasgeellpvdDLRLPGRHNLENALAALAAARALGVPPE 294
|
250 260 270
....*....|....*....|....*....|....*..
gi 2038730098 318 DIKKGIAATR-VPGRMEVLTQKNGAKvFIDyahngDS 353
Cdd:COG0771 295 AIREALRSFKgLPHRLEFVAEINGVR-FIN-----DS 325
|
|
| Mur_ligase_C |
pfam02875 |
Mur ligase family, glutamate ligase domain; This family contains a number of related ligase ... |
328-415 |
6.24e-19 |
|
Mur ligase family, glutamate ligase domain; This family contains a number of related ligase enzymes which have EC numbers 6.3.2.*. This family includes: MurC, MurD, MurE, MurF, Mpl and FolC. MurC, MurD, Mure and MurF catalyze consecutive steps in the synthesis of peptidoglycan. Peptidoglycan consists of a sheet of two sugar derivatives, with one of these N-acetylmuramic acid attaching to a small pentapeptide. The pentapeptide is is made of L-alanine, D-glutamic acid, Meso-diaminopimelic acid and D-alanyl alanine. The peptide moiety is synthesized by successively adding these amino acids to UDP-N-acetylmuramic acid. MurC transfers the L-alanine, MurD transfers the D-glutamate, MurE transfers the diaminopimelic acid, and MurF transfers the D-alanyl alanine. This family also includes Folylpolyglutamate synthase that transfers glutamate to folylpolyglutamate.
Pssm-ID: 460731 [Multi-domain] Cd Length: 87 Bit Score: 81.24 E-value: 6.24e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038730098 328 VPGRMEVLTQKNGAKVFIDYAHNGDSLKKLINVVETHQTGKIALVLGSTGNKGESRRKDFGLLLNQHPEIqVFLTADDPN 407
Cdd:pfam02875 1 VPGRLEVVGENNGVLVIDDYAHNPDAMEAALRALRNLFPGRLILVFGGMGDRDAEFHALLGRLAAALADV-VILTGDYPR 79
|
....*...
gi 2038730098 408 YEDPMAIA 415
Cdd:pfam02875 80 AEDPGAII 87
|
|
| PRK11929 |
PRK11929 |
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE ... |
38-454 |
2.38e-16 |
|
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE/UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase MurF;
Pssm-ID: 237025 [Multi-domain] Cd Length: 958 Bit Score: 82.06 E-value: 2.38e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038730098 38 ISYDSRKVTEDTLFFA-KGAAFK-KEYLLSAITQGLAWYVAEKDY-EVGIPVIIVNDIKKAMSLIAMEFygNPQEKLKLL 114
Cdd:PRK11929 529 VSTDSRSVGRGELFVAlRGENFDgHDYLPQAFAAGACAAVVERQVaDVDLPQIVVDDTRAALGRLATAW--RARFSLPVV 606
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038730098 115 AFTGTKGKTTAAYFAYNILSQGHRPA-MLSTmnttldgETFFKSALTTPESidLFDMMNQavqnDRTHLI-MEVSSQSYL 192
Cdd:PRK11929 607 AITGSNGKTTTKEMIAAILAAWQGEDrVLAT-------EGNFNNEIGVPLT--LLRLRAQ----HRAAVFeLGMNHPGEI 673
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038730098 193 VRRVYGLTFDVGVFLNISPDHIG------PIEHPSFEDYFYhkrlLMENSRAVIiNSDMDHFSVLKEQVEDQDHDFYGSQ 266
Cdd:PRK11929 674 AYLAAIAAPTVALVTNAQREHQEfmhsveAVARAKGEIIAA----LPEDGVAVV-NGDDPYTAIWAKLAGARRVLRFGLQ 748
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038730098 267 FDNQIENSKAFSFSATGKlAGDYDIQ-------------LIGNFNQENAVAAGLACLRLGASLEDIKKGIAATR-VPGRM 332
Cdd:PRK11929 749 PGADVYAEKIAKDISVGE-AGGTRCQvvtpagsaevylpLIGEHNLRNALAAIACALAAGASLKQIRAGLERFQpVAGRM 827
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038730098 333 EVLTQKNGAKVFID-YAHNGDSLKKLINVVETHQTGKIALVLG---STGNKGESRRKDFGLLLNQHPEIQVFLTADdpny 408
Cdd:PRK11929 828 QRRRLSCGTRIIDDtYNANPDSMRAAIDVLAELPNGPRALVLGdmlELGDNGPAMHREVGKYARQLGIDALITLGE---- 903
|
410 420 430 440
....*....|....*....|....*....|....*....|....*.
gi 2038730098 409 edpmAIADEISSYINHPVEKIADRQEAIKAAMAITNhELDAVIIAG 454
Cdd:PRK11929 904 ----AARDAAAAFGAGARGVCASVDEIIAALRGALP-EGDSVLIKG 944
|
|
| MurC |
COG0773 |
UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family [Cell wall ... |
202-464 |
5.72e-13 |
|
UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440536 [Multi-domain] Cd Length: 451 Bit Score: 70.48 E-value: 5.72e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038730098 202 DVGVFLNISPDHIgpiEH-PSFEDYF--YHKRL-LMENSRAVIINSDMDHFSVLKEQV--------EDQDHDFYGSQFDn 269
Cdd:COG0773 173 DIAVVTNIEADHL---DIyGDLEAIKeaFHEFArNVPFYGLLVLCADDPGLRELLPRCgrpvitygFSEDADYRAENIR- 248
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038730098 270 QIENSKAFSFSATGKLAGDYDIQLIGNFNQENAVAAGLACLRLGASLEDIKKGIAA-TRVPGRMEVLTQKNGAKVFIDYA 348
Cdd:COG0773 249 IDGGGSTFDVLRRGEELGEVELNLPGRHNVLNALAAIAVALELGVDPEAIAEALASfKGVKRRFELKGEVGGVTVIDDYA 328
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038730098 349 HNGDSLKKLINVV-ETHQTGKIALVLgstgnkgE----SRRKDFgllLNQHPEI-----QVFLTADDPNYEDPM------ 412
Cdd:COG0773 329 HHPTEIAATLAAArEKYPDRRLVAVF-------QphrySRTRDF---LDEFAEAlsladEVILLDIYAAREKPIpgvsse 398
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 2038730098 413 AIADEISSYiNHPVEKIADRQEAIKAAMAITnHELDAVIIAGKGaDCYQIIQ 464
Cdd:COG0773 399 DLAEAIRKR-GKDVVYVPDLDELVEALAEIA-RPGDVVLTMGAG-DIGGLGE 447
|
|
| murD |
PRK14106 |
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional |
110-382 |
1.20e-09 |
|
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional
Pssm-ID: 184511 [Multi-domain] Cd Length: 450 Bit Score: 60.37 E-value: 1.20e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038730098 110 KLKLLAFTGTKGKTTAayfaynilsqghrpamlstmnTTLDGETFFKSALTTPESIDLFDMMNQAVQN--DRTHLIMEVS 187
Cdd:PRK14106 107 KAPIVAITGTNGKTTT---------------------TTLLGEIFKNAGRKTLVAGNIGYPLIDAVEEygEDDIIVAEVS 165
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038730098 188 S-QSYLVRRvygLTFDVGVFLNISPDHIGpiEHPSFEDYFYHKRLLMENSRA---VIINSDMDHFSVLKEQVEDQ----- 258
Cdd:PRK14106 166 SfQLETIKE---FKPKVGCILNITPDHLD--RHKTMENYIKAKARIFENQRPsdyTVLNYDDPRTRSLAKKAKARviffs 240
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038730098 259 -DHDFYGSQFdnqIENSKAFsFSATGK----LAGDyDIQLIGNFNQENAVAAGLACLRLGASLEDIKKGIAATR-VPGRM 332
Cdd:PRK14106 241 rKSLLEEGVF---VKNGKIV-ISLGGKeeevIDID-EIFIPGEHNLENALAATAAAYLLGISPDVIANTLKTFKgVEHRI 315
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 2038730098 333 EVLTQKNGAKVFIDY-AHNGDSLKKLINVVEThqtgKIALVLGSTgNKGES 382
Cdd:PRK14106 316 EFVAEINGVKFINDSkGTNPDAAIKALEAYET----PIVLIAGGY-DKGSD 361
|
|
| PLN02913 |
PLN02913 |
dihydrofolate synthetase |
101-405 |
2.85e-08 |
|
dihydrofolate synthetase
Pssm-ID: 178501 [Multi-domain] Cd Length: 510 Bit Score: 55.98 E-value: 2.85e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038730098 101 MEFYGNPQEKLKLLAFTGTKGKTTAAYFAYNIL-SQGH------RPAMLST---MNTTLDGETFFKSALTtpesiDLFDM 170
Cdd:PLN02913 65 MDRLGNPHSKFKAVHVAGTKGKGSTAAFLSNILrAQGYsvgcytSPHLRSIrerISVGKLGKPVSTNTLN-----DLFHG 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038730098 171 ----MNQAVQNDR---THL-IMEVSSQSYL----------------------VRRVYGLTfdVGVFLNISPDHI------ 214
Cdd:PLN02913 140 ikpiLDEAIQLENgslTHFeVLTALAFKLFaqenvdiavieaglggardatnVIDSSGLA--ASVITTIGEEHLaalggs 217
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038730098 215 ---------GPIEH-----------PSFEDYFYHKRLLMENSraVIINSDMDHFSVLKEQVEDQDHDFYGSqfDNQIENS 274
Cdd:PLN02913 218 lesialaksGIIKQgrpvvlggpflPHIESILRDKASSMNSP--VVSASDPGVRSSIKGIITDNGKPCQSC--DIVIRVE 293
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038730098 275 KAFSFSATgklAGDYDIQLIGNFNQENAVAAGLA--CLRL-GASLED--IKKGIAATRVPGRMEVLTQK-------NGAK 342
Cdd:PLN02913 294 KDDPLFIE---LSDVNLRMLGSHQLQNAVTAACAalCLRDqGWRISDasIRAGLENTNLLGRSQFLTSKeaevlglPGAT 370
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2038730098 343 VFIDYAHNGDSLKKLINVVET-HQTGKIALVLGSTGNKGE-SRRKDFglLLNQHPEIqVFLTADD 405
Cdd:PLN02913 371 VLLDGAHTKESAKALVDTIKTaFPEARLALVVAMASDKDHlAFASEF--LSGLKPEA-VFLTEAD 432
|
|
| murF |
PRK10773 |
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed |
36-332 |
9.78e-07 |
|
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed
Pssm-ID: 182718 [Multi-domain] Cd Length: 453 Bit Score: 51.19 E-value: 9.78e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038730098 36 DSISYDSRKVTEDTLFFA-KGAAFK-KEYLLSAITQGLAWYVAEKDYEVGIPVIIVNDIKKAMSLIAMefYGNPQEKLKL 113
Cdd:PRK10773 25 DAVTTDTRKVTPGCLFVAlKGERFDaHDFADDAKAAGAGALLVSRPLDIDLPQLVVKDTRLAFGQLAA--WVRQQVPARV 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038730098 114 LAFTGTKGKTTAAYFAYNILSQ-GHrpamlstmntTLDGETFFKSALTTPesIDLFDMMNQ---AVQNDRTHLIMEVSSQ 189
Cdd:PRK10773 103 VALTGSSGKTSVKEMTAAILRQcGN----------TLYTAGNLNNDIGVP--LTLLRLTPEhdyAVIELGANHQGEIAYT 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038730098 190 SYLVRRVYGLTFdvgvflNISPDHI-------------GPIehpsfedyFYHkrlLMENSRAvIINSDMDHF----SVLK 252
Cdd:PRK10773 171 VSLTRPEAALVN------NLAAAHLegfgslagvakakGEI--------FSG---LPENGIA-IMNADSNDWlnwqSVIG 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038730098 253 EQ------VEDQDH-DFYGSqfdNQIENSKAFSFSATGKLaGDYDIQL--IGNFNQENAVAAGLACLRLGASLEDIKKGI 323
Cdd:PRK10773 233 SKtvwrfsPNAANSvDFTAT---NIHVTSHGTEFTLHTPT-GSVDVLLplPGRHNIANALAAAALAMSVGATLDAVKAGL 308
|
330
....*....|
gi 2038730098 324 AATR-VPGRM 332
Cdd:PRK10773 309 ANLKaVPGRL 318
|
|
| |
