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Conserved domains on  [gi|199431355|emb|CAG86682|]
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DEHA2D01892p [Debaryomyces hansenii CBS767]

Protein Classification

insulinase family protein( domain architecture ID 1002320)

insulinase family protein (peptidase M16) is a zinc-dependent peptidase that cleaves small peptides close to a terminus, often including bonds on the amino side of basic residues such as arginine

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Cym1 super family cl34067
Zn-dependent peptidase, M16 (insulinase) family [Posttranslational modification, protein ...
39-1061 0e+00

Zn-dependent peptidase, M16 (insulinase) family [Posttranslational modification, protein turnover, chaperones];


The actual alignment was detected with superfamily member COG1026:

Pssm-ID: 440649 [Multi-domain]  Cd Length: 974  Bit Score: 698.09  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 199431355   39 KYPIGLNMHGYVIEQVQPIPEFSLVAVKLKHSRTGSEHLHLDTpNDKNNVFSVAFKTNAPDATGVPHILEHTTLCGSFKY 118
Cdd:COG1026     2 TLKVGKTHHGFELLREEYIEELNSTAYLFRHEKTGARLLHLAN-DDDNKVFSIAFRTPPEDSTGVAHILEHSVLCGSRKY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 199431355  119 PVRDPFFKMLNRSLSNFMNAMTGHDYTYYPFATTNAKDFENLMDVYLSSVFEPLLTHESFMQEGWRLEnsdLSDPKSPII 198
Cdd:COG1026    81 PVKDPFFELLKGSLNTFLNAMTYSDKTAYPVASRNEKDFYNLMDVYLDAVFFPNLDPLIFAQEGWRYE---LEEPDSPLT 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 199431355  199 FKGVVYNEMKGQYSN--SAYYYWIK---FQEAIYGslNNSGGNPNEITDLRYEDLVDFHSSNYHPSNAKTFTYGNIELVN 273
Cdd:COG1026   158 YKGVVYNEMKGAMSSpdSVLWRALQkslFPDTTYG--YNSGGDPEVIPDLTYEQFLAFHKKYYHPSNAYIYLYGDIDAEE 235
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 199431355  274 HLNKLNE-FFESFGSRGIRTNVrkpitELNPNYESDVTVKGPLDTMSSRPIEEQYKSSITWVIGNPLDeskLYDVFKWKV 352
Cdd:COG1026   236 HLAFLDEeYLSRFERLEVDSEV-----PDQKRFSAPREVEETYPVAEEEDTENKTYLSLNWLLGESTD---LEESLALQL 307
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 199431355  353 LSSLLCDGHNSPFYQELIEKEYGEDFAVnyGLDATTALLSFTIGLNNLSLEKAknleDKvrgifVEKIIPE-LQKGKESG 431
Cdd:COG1026   308 LSYVLLGNSASPLKKALLDSGLGKDVSG--GLEDSLRQPVFSIGLKGSEPEKA----EA-----FEKLILEtLEKLVEEG 376
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 199431355  432 FN-DRIEAILHQIELNFK----NHKPeFGIGLLSSVVSTWVNGLNPVKSLQIDHILNRFKEdyKLNGLKMFQDLLDESVL 506
Cdd:COG1026   377 IDkELLEAALNQLEFSLReidgGSYP-YGLQLILRALDSWLYGGDPLALLRYEPALEKLRE--KIKDPGYFENLIRKYLL 453
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 199431355  507 kDDTPKFKFTMEPDESFGKNLTSQETERLNKKIEALTEEDKEIIYKRSIELAEKQKKE---EDVSALPTLTVKDIPREGD 583
Cdd:COG1026   454 -DNPHRVLLTLKPDPGLAERKEAAEKEKLAAIKASLSEEEKQAIIEQTKALKERQEQEdspEALATLPKLTLEDIPKEVK 532
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 199431355  584 FYPLDFADINSKKLQKRIVDTNGLIYMNATKDISYLPSKYYEYLPLFDCCLTNLaGTSKTPITELEIKIQKLTGGVTFNV 663
Cdd:COG1026   533 EIPLEEEELGGVPVLFHDLFTNGIVYLDLYFDLPALPEELLPYLPLLTDLLGEL-GTGKYDYLELSNEIAAYTGGISAST 611
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 199431355  664 SAKTDPFDISKTNMKFMLSGMALKDKSQNVYDLWFEILTQTKFDSEdeqvvDKLFTLVKNLGQNQMNTIADSGHSYANSY 743
Cdd:COG1026   612 SVYTNIDDVQEYRPYFVVSGKALARNLDKLFELLKEILLNTRFDDK-----KRLRELVAQIKARLEQSLTGSGHSLAMSR 686
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 199431355  744 SNSQLTPTKYIHNLIGGIGQVSFISDLNRKLETEGRDFLKKellpvLKDIQRHLVNGftdgnhSGFEYSLVGDSESVIKN 823
Cdd:COG1026   687 ASSYFSPAAAYSEQLSGLSYYRFLKDLEENLDEKLEELAEK-----LQELADKLFNR------PNLLISVTGEEEELEAF 755
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 199431355  824 EKMIKEFDDLLTANsnrvagTNELSSLISQFNSNKLGLNNNGrstlidlpfQVGYASLAKLGAAYTSKDGAALRVLSQLL 903
Cdd:COG1026   756 KKALEAFIASLPAG------TAAPFKYPFDAEPKNEGWITSS---------QVNYVAKAYNFVPLGHEYAGALLVLAGIL 820
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 199431355  904 TFKHLHSVIREANGAYGGGLSFDGLGGCLNFYSYRDPNPLTSVQSFKDSTSVAlgkminsENNGWSPKDLQEAKLTIFQG 983
Cdd:COG1026   821 RNGYLWNKIRVQGGAYGGGASFDSLSGNFRFYSYRDPNLKETLDVYDEAPDWL-------RNFDLSERELEKAIIGTISS 893
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 199431355  984 VDAPSHISSQGSLDF---LEHITDEMRQERRERFLDVTYEDLKNVTEKYLLNGSQDIVTVIGDNETLKiDSSDAQWNIKK 1060
Cdd:COG1026   894 LDKPLSPAGKGKRAFhryLSGRTPEDRQKFRDEILSTTLEDLRRVAELYLDVLKEASIAVIGNEEKIE-EAKDLFDEIIK 972

                  .
gi 199431355 1061 L 1061
Cdd:COG1026   973 L 973
 
Name Accession Description Interval E-value
Cym1 COG1026
Zn-dependent peptidase, M16 (insulinase) family [Posttranslational modification, protein ...
39-1061 0e+00

Zn-dependent peptidase, M16 (insulinase) family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440649 [Multi-domain]  Cd Length: 974  Bit Score: 698.09  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 199431355   39 KYPIGLNMHGYVIEQVQPIPEFSLVAVKLKHSRTGSEHLHLDTpNDKNNVFSVAFKTNAPDATGVPHILEHTTLCGSFKY 118
Cdd:COG1026     2 TLKVGKTHHGFELLREEYIEELNSTAYLFRHEKTGARLLHLAN-DDDNKVFSIAFRTPPEDSTGVAHILEHSVLCGSRKY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 199431355  119 PVRDPFFKMLNRSLSNFMNAMTGHDYTYYPFATTNAKDFENLMDVYLSSVFEPLLTHESFMQEGWRLEnsdLSDPKSPII 198
Cdd:COG1026    81 PVKDPFFELLKGSLNTFLNAMTYSDKTAYPVASRNEKDFYNLMDVYLDAVFFPNLDPLIFAQEGWRYE---LEEPDSPLT 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 199431355  199 FKGVVYNEMKGQYSN--SAYYYWIK---FQEAIYGslNNSGGNPNEITDLRYEDLVDFHSSNYHPSNAKTFTYGNIELVN 273
Cdd:COG1026   158 YKGVVYNEMKGAMSSpdSVLWRALQkslFPDTTYG--YNSGGDPEVIPDLTYEQFLAFHKKYYHPSNAYIYLYGDIDAEE 235
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 199431355  274 HLNKLNE-FFESFGSRGIRTNVrkpitELNPNYESDVTVKGPLDTMSSRPIEEQYKSSITWVIGNPLDeskLYDVFKWKV 352
Cdd:COG1026   236 HLAFLDEeYLSRFERLEVDSEV-----PDQKRFSAPREVEETYPVAEEEDTENKTYLSLNWLLGESTD---LEESLALQL 307
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 199431355  353 LSSLLCDGHNSPFYQELIEKEYGEDFAVnyGLDATTALLSFTIGLNNLSLEKAknleDKvrgifVEKIIPE-LQKGKESG 431
Cdd:COG1026   308 LSYVLLGNSASPLKKALLDSGLGKDVSG--GLEDSLRQPVFSIGLKGSEPEKA----EA-----FEKLILEtLEKLVEEG 376
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 199431355  432 FN-DRIEAILHQIELNFK----NHKPeFGIGLLSSVVSTWVNGLNPVKSLQIDHILNRFKEdyKLNGLKMFQDLLDESVL 506
Cdd:COG1026   377 IDkELLEAALNQLEFSLReidgGSYP-YGLQLILRALDSWLYGGDPLALLRYEPALEKLRE--KIKDPGYFENLIRKYLL 453
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 199431355  507 kDDTPKFKFTMEPDESFGKNLTSQETERLNKKIEALTEEDKEIIYKRSIELAEKQKKE---EDVSALPTLTVKDIPREGD 583
Cdd:COG1026   454 -DNPHRVLLTLKPDPGLAERKEAAEKEKLAAIKASLSEEEKQAIIEQTKALKERQEQEdspEALATLPKLTLEDIPKEVK 532
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 199431355  584 FYPLDFADINSKKLQKRIVDTNGLIYMNATKDISYLPSKYYEYLPLFDCCLTNLaGTSKTPITELEIKIQKLTGGVTFNV 663
Cdd:COG1026   533 EIPLEEEELGGVPVLFHDLFTNGIVYLDLYFDLPALPEELLPYLPLLTDLLGEL-GTGKYDYLELSNEIAAYTGGISAST 611
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 199431355  664 SAKTDPFDISKTNMKFMLSGMALKDKSQNVYDLWFEILTQTKFDSEdeqvvDKLFTLVKNLGQNQMNTIADSGHSYANSY 743
Cdd:COG1026   612 SVYTNIDDVQEYRPYFVVSGKALARNLDKLFELLKEILLNTRFDDK-----KRLRELVAQIKARLEQSLTGSGHSLAMSR 686
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 199431355  744 SNSQLTPTKYIHNLIGGIGQVSFISDLNRKLETEGRDFLKKellpvLKDIQRHLVNGftdgnhSGFEYSLVGDSESVIKN 823
Cdd:COG1026   687 ASSYFSPAAAYSEQLSGLSYYRFLKDLEENLDEKLEELAEK-----LQELADKLFNR------PNLLISVTGEEEELEAF 755
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 199431355  824 EKMIKEFDDLLTANsnrvagTNELSSLISQFNSNKLGLNNNGrstlidlpfQVGYASLAKLGAAYTSKDGAALRVLSQLL 903
Cdd:COG1026   756 KKALEAFIASLPAG------TAAPFKYPFDAEPKNEGWITSS---------QVNYVAKAYNFVPLGHEYAGALLVLAGIL 820
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 199431355  904 TFKHLHSVIREANGAYGGGLSFDGLGGCLNFYSYRDPNPLTSVQSFKDSTSVAlgkminsENNGWSPKDLQEAKLTIFQG 983
Cdd:COG1026   821 RNGYLWNKIRVQGGAYGGGASFDSLSGNFRFYSYRDPNLKETLDVYDEAPDWL-------RNFDLSERELEKAIIGTISS 893
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 199431355  984 VDAPSHISSQGSLDF---LEHITDEMRQERRERFLDVTYEDLKNVTEKYLLNGSQDIVTVIGDNETLKiDSSDAQWNIKK 1060
Cdd:COG1026   894 LDKPLSPAGKGKRAFhryLSGRTPEDRQKFRDEILSTTLEDLRRVAELYLDVLKEASIAVIGNEEKIE-EAKDLFDEIIK 972

                  .
gi 199431355 1061 L 1061
Cdd:COG1026   973 L 973
PTZ00432 PTZ00432
falcilysin; Provisional
57-1058 1.28e-87

falcilysin; Provisional


Pssm-ID: 240416 [Multi-domain]  Cd Length: 1119  Bit Score: 305.96  E-value: 1.28e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 199431355   57 IPEFSLVAVKLKHSRTGSEHLHLDT--PNDKNNVFSVAFKTNAPDATGVPHILEHTTLCGSFKYPVRDPFFKMLNRSLSN 134
Cdd:PTZ00432   84 LPDFGMVATVYSHKKTGLQVISLKTndSSGKEMCFDFYVPTPPHNDKGIPHILEHSVLSGSKKYNYKDSFSLLVQGGFNS 163
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 199431355  135 FMNAMTGHDYTYYPFATTNAKDFENLMDVYLSSVFEPLLTHES--FMQEGWRLENSDLSDPKSP-----------IIFKG 201
Cdd:PTZ00432  164 FLNAYTFKDRTSYLFASTNEKDFYNTADVYMDSVFQPNILEDKdiFKQEGWHYKVTKLKDDEKNadelgnvhdrhVSYSG 243
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 199431355  202 VVYNEMKGQYSNSAYYywikFQEAIYGSL------NNSGGNPNEITDLRYEDLVDFHSSNYHPSNAKTFTYGNIELVNHL 275
Cdd:PTZ00432  244 IVYSEMKKRFSDPLSF----GYSVIYQNLfsnvykYDSGGDPKDIVELTYEELVEFYKTYYGPKTATVYFYGPNDVTERL 319
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 199431355  276 NKLNEFFESFGSRGIRTNVRKPITeLNPNYESDVTVKGPL---DTMSSRPIEEQYKSSITWVIgNPL-------DESKL- 344
Cdd:PTZ00432  320 EFVDNYLTKHPKTGQLSHTAYRED-ADENLLYEEYKDKPKhvkKKFSSHSEEEENLMSVSWLL-NPKhngskdyDKSLId 397
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 199431355  345 -YDVFKWKVLSSLLCDGHNSPFYQELIEKEYGEDfAVNYGLDATTALLSFTIGLNNLSlEKAKNLEDKVRGIFVEKIIPE 423
Cdd:PTZ00432  398 pVDYLALLVLNYLLLGTPESVLYKALIDSGLGKK-VVGSGLDDYFKQSIFSIGLKGIK-ETNEKRKDKVHYTFEKVVLNA 475
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 199431355  424 LQKGKESGFN-DRIEAILHQIELNFKNHKPEF---GIGLLSSVVSTWVNGLNPVKSLQIDHILNRFKEDYKlNGLKMFQD 499
Cdd:PTZ00432  476 LTKVVTEGFNkSAVEASLNNIEFVMKELNLGTypkGLMLIFLMQSRLQYGKDPFEILRFEKLLNELKLRID-NESKYLEK 554
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 199431355  500 LLDESVLKDDTpKFKFTMEPDES--FGKNLTSQETERLNKKIEALTEEDKEIIYKRSIELAEKQKKEED---VSALPTLT 574
Cdd:PTZ00432  555 LIEKHLLNNNH-RVTVHLEAVESskYEKEFNKLVKDELKERLSHLTKEQVDEMEKAYEKFKKEREADDDpehLDSFPILS 633
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 199431355  575 VKDIPREGDFYPLDFADINSKKLQKRI---------------VDTNGLIYMNATKDISYLPSKYYEYLPLFdCCLTNLAG 639
Cdd:PTZ00432  634 LSDLNKETEEIPTKLYKLSSDSLKENMdldsdggsvtvlvhpIESRGILYLDFAFSLDSLTVDELKYLNLF-KALLKENG 712
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 199431355  640 TSKTPITELEIKIQKLTGGVTFNVSAKTDPFDISKTNMK-----FMLSGMALKDKSQNVYDLWFEILTQTKFdSEDEQVV 714
Cdd:PTZ00432  713 TDKLSSEEFTYKREKNLGGLSASTAFYSETNNLTYDDPYngvgyLNVRAKVLKHKVNEMVDIVLEALKDADF-SNSKKGV 791
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 199431355  715 DKLFTLVknlgqNQMNT-IADSGHSYANSYSNSQLTPTKYIHNLIGGIGQVSFISD-LNRKLETEGRDFLKK--ELLPVL 790
Cdd:PTZ00432  792 EILKRKI-----NGMKTvFSSKGHKFALKRMKSKFSVSDYADELVNGYSQLLFLKEtLVPLAEKDWSKVESKlnEIRNKL 866
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 199431355  791 KDIQRHLVNGFTDgnhSGFEYSLVGDSESVIKNEKMIKEFDDLLTANSNRVagtnelssliSQFNSNKLgLNNNGRSTLI 870
Cdd:PTZ00432  867 LSMKNLTVNVTGD---SELLDSLLDDSTTFLKKLSSTFKENDNKSSDKVWV----------KEVLDKKL-MESVDKNEFI 932
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 199431355  871 DLPFQVGYASLAklGAAYTSKD--GAALRVLSQLLTFKHLHSVIREANGAYG--GGLSFDglgGCLNFYSYRDPNPLTSV 946
Cdd:PTZ00432  933 VLPTRVNFVGMG--GKLFDKSDkvDGSFQVIVHYLKNSYLWKTVRMSLGAYGvfADLLYT---GHVIFMSYADPNFEKTL 1007
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 199431355  947 QSFKDSTSvALGKMINSenngWSPKDLQEAKLTIFQGVDAPSHISSQGSLDFLEHI---TDEMRQERRERFLDVTYEDLK 1023
Cdd:PTZ00432 1008 EVYKEVAS-ALREAAET----LTDKDLLRYKIGKISNIDKPLHVDELSKLALLRIIrneSDEDRQKFRKDILETTKEDFY 1082
                        1050      1060      1070
                  ....*....|....*....|....*....|....*...
gi 199431355 1024 NVTEKylLNGSQD---IVTVIGDNETLKIDSSDAQWNI 1058
Cdd:PTZ00432 1083 RLADL--MEKSKEwekVIAVVNSKTSDTAPSDFKQLHI 1118
M16C_assoc pfam08367
Peptidase M16C associated; This domain appears in eukaryotes as well as bacteria and tends to ...
517-770 1.14e-79

Peptidase M16C associated; This domain appears in eukaryotes as well as bacteria and tends to be found near the C-terminus of the metalloprotease M16C (pfam05193).


Pssm-ID: 462447 [Multi-domain]  Cd Length: 248  Bit Score: 260.54  E-value: 1.14e-79
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 199431355   517 MEPDESFGKNLTSQETERLNKKIEALTEEDKEIIYKRSIELAEKQKKE--EDVSALPTLTVKDIPREGDFYPLDfaDINS 594
Cdd:pfam08367    1 MKPDEGLSEELEEEEKERLAAKKASLSEEEKEKIVERTLELKERQEAPdsEDLSCLPTLTLSDIPREIEVEPEE--EIGG 78
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 199431355   595 KKLQKRIVDTNGLIYMNATKDISYLPSKYYEYLPLFDCCLTNLaGTSKTPITELEIKIQKLTGGVTFNVSAKTDPFDISK 674
Cdd:pfam08367   79 VPVLHHDVPTNGIVYFRAIFDLSDLPEELLPYLPLFTSVLTEL-GTKKYDYEELEQEINLKTGGISASPSVSSDPDDLDK 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 199431355   675 TNMKFMLSGMALKDKSQNVYDLWFEILTQTKFDSEdeqvvDKLFTLVKNLGQNQMNTIADSGHSYANSYSNSQLTPTKYI 754
Cdd:pfam08367  158 YEPGFVVSGKALDRNVPKMFDLLREILLETKFDDK-----ERLKELVQESKSRLENSIASSGHSYAMSRAASYLSPAGAL 232
                          250
                   ....*....|....*.
gi 199431355   755 HNLIGGIGQVSFISDL 770
Cdd:pfam08367  233 SEQLSGLSQYKFLKDL 248
 
Name Accession Description Interval E-value
Cym1 COG1026
Zn-dependent peptidase, M16 (insulinase) family [Posttranslational modification, protein ...
39-1061 0e+00

Zn-dependent peptidase, M16 (insulinase) family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440649 [Multi-domain]  Cd Length: 974  Bit Score: 698.09  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 199431355   39 KYPIGLNMHGYVIEQVQPIPEFSLVAVKLKHSRTGSEHLHLDTpNDKNNVFSVAFKTNAPDATGVPHILEHTTLCGSFKY 118
Cdd:COG1026     2 TLKVGKTHHGFELLREEYIEELNSTAYLFRHEKTGARLLHLAN-DDDNKVFSIAFRTPPEDSTGVAHILEHSVLCGSRKY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 199431355  119 PVRDPFFKMLNRSLSNFMNAMTGHDYTYYPFATTNAKDFENLMDVYLSSVFEPLLTHESFMQEGWRLEnsdLSDPKSPII 198
Cdd:COG1026    81 PVKDPFFELLKGSLNTFLNAMTYSDKTAYPVASRNEKDFYNLMDVYLDAVFFPNLDPLIFAQEGWRYE---LEEPDSPLT 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 199431355  199 FKGVVYNEMKGQYSN--SAYYYWIK---FQEAIYGslNNSGGNPNEITDLRYEDLVDFHSSNYHPSNAKTFTYGNIELVN 273
Cdd:COG1026   158 YKGVVYNEMKGAMSSpdSVLWRALQkslFPDTTYG--YNSGGDPEVIPDLTYEQFLAFHKKYYHPSNAYIYLYGDIDAEE 235
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 199431355  274 HLNKLNE-FFESFGSRGIRTNVrkpitELNPNYESDVTVKGPLDTMSSRPIEEQYKSSITWVIGNPLDeskLYDVFKWKV 352
Cdd:COG1026   236 HLAFLDEeYLSRFERLEVDSEV-----PDQKRFSAPREVEETYPVAEEEDTENKTYLSLNWLLGESTD---LEESLALQL 307
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 199431355  353 LSSLLCDGHNSPFYQELIEKEYGEDFAVnyGLDATTALLSFTIGLNNLSLEKAknleDKvrgifVEKIIPE-LQKGKESG 431
Cdd:COG1026   308 LSYVLLGNSASPLKKALLDSGLGKDVSG--GLEDSLRQPVFSIGLKGSEPEKA----EA-----FEKLILEtLEKLVEEG 376
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 199431355  432 FN-DRIEAILHQIELNFK----NHKPeFGIGLLSSVVSTWVNGLNPVKSLQIDHILNRFKEdyKLNGLKMFQDLLDESVL 506
Cdd:COG1026   377 IDkELLEAALNQLEFSLReidgGSYP-YGLQLILRALDSWLYGGDPLALLRYEPALEKLRE--KIKDPGYFENLIRKYLL 453
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 199431355  507 kDDTPKFKFTMEPDESFGKNLTSQETERLNKKIEALTEEDKEIIYKRSIELAEKQKKE---EDVSALPTLTVKDIPREGD 583
Cdd:COG1026   454 -DNPHRVLLTLKPDPGLAERKEAAEKEKLAAIKASLSEEEKQAIIEQTKALKERQEQEdspEALATLPKLTLEDIPKEVK 532
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 199431355  584 FYPLDFADINSKKLQKRIVDTNGLIYMNATKDISYLPSKYYEYLPLFDCCLTNLaGTSKTPITELEIKIQKLTGGVTFNV 663
Cdd:COG1026   533 EIPLEEEELGGVPVLFHDLFTNGIVYLDLYFDLPALPEELLPYLPLLTDLLGEL-GTGKYDYLELSNEIAAYTGGISAST 611
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 199431355  664 SAKTDPFDISKTNMKFMLSGMALKDKSQNVYDLWFEILTQTKFDSEdeqvvDKLFTLVKNLGQNQMNTIADSGHSYANSY 743
Cdd:COG1026   612 SVYTNIDDVQEYRPYFVVSGKALARNLDKLFELLKEILLNTRFDDK-----KRLRELVAQIKARLEQSLTGSGHSLAMSR 686
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 199431355  744 SNSQLTPTKYIHNLIGGIGQVSFISDLNRKLETEGRDFLKKellpvLKDIQRHLVNGftdgnhSGFEYSLVGDSESVIKN 823
Cdd:COG1026   687 ASSYFSPAAAYSEQLSGLSYYRFLKDLEENLDEKLEELAEK-----LQELADKLFNR------PNLLISVTGEEEELEAF 755
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 199431355  824 EKMIKEFDDLLTANsnrvagTNELSSLISQFNSNKLGLNNNGrstlidlpfQVGYASLAKLGAAYTSKDGAALRVLSQLL 903
Cdd:COG1026   756 KKALEAFIASLPAG------TAAPFKYPFDAEPKNEGWITSS---------QVNYVAKAYNFVPLGHEYAGALLVLAGIL 820
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 199431355  904 TFKHLHSVIREANGAYGGGLSFDGLGGCLNFYSYRDPNPLTSVQSFKDSTSVAlgkminsENNGWSPKDLQEAKLTIFQG 983
Cdd:COG1026   821 RNGYLWNKIRVQGGAYGGGASFDSLSGNFRFYSYRDPNLKETLDVYDEAPDWL-------RNFDLSERELEKAIIGTISS 893
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 199431355  984 VDAPSHISSQGSLDF---LEHITDEMRQERRERFLDVTYEDLKNVTEKYLLNGSQDIVTVIGDNETLKiDSSDAQWNIKK 1060
Cdd:COG1026   894 LDKPLSPAGKGKRAFhryLSGRTPEDRQKFRDEILSTTLEDLRRVAELYLDVLKEASIAVIGNEEKIE-EAKDLFDEIIK 972

                  .
gi 199431355 1061 L 1061
Cdd:COG1026   973 L 973
PTZ00432 PTZ00432
falcilysin; Provisional
57-1058 1.28e-87

falcilysin; Provisional


Pssm-ID: 240416 [Multi-domain]  Cd Length: 1119  Bit Score: 305.96  E-value: 1.28e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 199431355   57 IPEFSLVAVKLKHSRTGSEHLHLDT--PNDKNNVFSVAFKTNAPDATGVPHILEHTTLCGSFKYPVRDPFFKMLNRSLSN 134
Cdd:PTZ00432   84 LPDFGMVATVYSHKKTGLQVISLKTndSSGKEMCFDFYVPTPPHNDKGIPHILEHSVLSGSKKYNYKDSFSLLVQGGFNS 163
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 199431355  135 FMNAMTGHDYTYYPFATTNAKDFENLMDVYLSSVFEPLLTHES--FMQEGWRLENSDLSDPKSP-----------IIFKG 201
Cdd:PTZ00432  164 FLNAYTFKDRTSYLFASTNEKDFYNTADVYMDSVFQPNILEDKdiFKQEGWHYKVTKLKDDEKNadelgnvhdrhVSYSG 243
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 199431355  202 VVYNEMKGQYSNSAYYywikFQEAIYGSL------NNSGGNPNEITDLRYEDLVDFHSSNYHPSNAKTFTYGNIELVNHL 275
Cdd:PTZ00432  244 IVYSEMKKRFSDPLSF----GYSVIYQNLfsnvykYDSGGDPKDIVELTYEELVEFYKTYYGPKTATVYFYGPNDVTERL 319
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 199431355  276 NKLNEFFESFGSRGIRTNVRKPITeLNPNYESDVTVKGPL---DTMSSRPIEEQYKSSITWVIgNPL-------DESKL- 344
Cdd:PTZ00432  320 EFVDNYLTKHPKTGQLSHTAYRED-ADENLLYEEYKDKPKhvkKKFSSHSEEEENLMSVSWLL-NPKhngskdyDKSLId 397
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 199431355  345 -YDVFKWKVLSSLLCDGHNSPFYQELIEKEYGEDfAVNYGLDATTALLSFTIGLNNLSlEKAKNLEDKVRGIFVEKIIPE 423
Cdd:PTZ00432  398 pVDYLALLVLNYLLLGTPESVLYKALIDSGLGKK-VVGSGLDDYFKQSIFSIGLKGIK-ETNEKRKDKVHYTFEKVVLNA 475
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 199431355  424 LQKGKESGFN-DRIEAILHQIELNFKNHKPEF---GIGLLSSVVSTWVNGLNPVKSLQIDHILNRFKEDYKlNGLKMFQD 499
Cdd:PTZ00432  476 LTKVVTEGFNkSAVEASLNNIEFVMKELNLGTypkGLMLIFLMQSRLQYGKDPFEILRFEKLLNELKLRID-NESKYLEK 554
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 199431355  500 LLDESVLKDDTpKFKFTMEPDES--FGKNLTSQETERLNKKIEALTEEDKEIIYKRSIELAEKQKKEED---VSALPTLT 574
Cdd:PTZ00432  555 LIEKHLLNNNH-RVTVHLEAVESskYEKEFNKLVKDELKERLSHLTKEQVDEMEKAYEKFKKEREADDDpehLDSFPILS 633
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 199431355  575 VKDIPREGDFYPLDFADINSKKLQKRI---------------VDTNGLIYMNATKDISYLPSKYYEYLPLFdCCLTNLAG 639
Cdd:PTZ00432  634 LSDLNKETEEIPTKLYKLSSDSLKENMdldsdggsvtvlvhpIESRGILYLDFAFSLDSLTVDELKYLNLF-KALLKENG 712
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 199431355  640 TSKTPITELEIKIQKLTGGVTFNVSAKTDPFDISKTNMK-----FMLSGMALKDKSQNVYDLWFEILTQTKFdSEDEQVV 714
Cdd:PTZ00432  713 TDKLSSEEFTYKREKNLGGLSASTAFYSETNNLTYDDPYngvgyLNVRAKVLKHKVNEMVDIVLEALKDADF-SNSKKGV 791
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 199431355  715 DKLFTLVknlgqNQMNT-IADSGHSYANSYSNSQLTPTKYIHNLIGGIGQVSFISD-LNRKLETEGRDFLKK--ELLPVL 790
Cdd:PTZ00432  792 EILKRKI-----NGMKTvFSSKGHKFALKRMKSKFSVSDYADELVNGYSQLLFLKEtLVPLAEKDWSKVESKlnEIRNKL 866
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 199431355  791 KDIQRHLVNGFTDgnhSGFEYSLVGDSESVIKNEKMIKEFDDLLTANSNRVagtnelssliSQFNSNKLgLNNNGRSTLI 870
Cdd:PTZ00432  867 LSMKNLTVNVTGD---SELLDSLLDDSTTFLKKLSSTFKENDNKSSDKVWV----------KEVLDKKL-MESVDKNEFI 932
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 199431355  871 DLPFQVGYASLAklGAAYTSKD--GAALRVLSQLLTFKHLHSVIREANGAYG--GGLSFDglgGCLNFYSYRDPNPLTSV 946
Cdd:PTZ00432  933 VLPTRVNFVGMG--GKLFDKSDkvDGSFQVIVHYLKNSYLWKTVRMSLGAYGvfADLLYT---GHVIFMSYADPNFEKTL 1007
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 199431355  947 QSFKDSTSvALGKMINSenngWSPKDLQEAKLTIFQGVDAPSHISSQGSLDFLEHI---TDEMRQERRERFLDVTYEDLK 1023
Cdd:PTZ00432 1008 EVYKEVAS-ALREAAET----LTDKDLLRYKIGKISNIDKPLHVDELSKLALLRIIrneSDEDRQKFRKDILETTKEDFY 1082
                        1050      1060      1070
                  ....*....|....*....|....*....|....*...
gi 199431355 1024 NVTEKylLNGSQD---IVTVIGDNETLKIDSSDAQWNI 1058
Cdd:PTZ00432 1083 RLADL--MEKSKEwekVIAVVNSKTSDTAPSDFKQLHI 1118
M16C_assoc pfam08367
Peptidase M16C associated; This domain appears in eukaryotes as well as bacteria and tends to ...
517-770 1.14e-79

Peptidase M16C associated; This domain appears in eukaryotes as well as bacteria and tends to be found near the C-terminus of the metalloprotease M16C (pfam05193).


Pssm-ID: 462447 [Multi-domain]  Cd Length: 248  Bit Score: 260.54  E-value: 1.14e-79
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 199431355   517 MEPDESFGKNLTSQETERLNKKIEALTEEDKEIIYKRSIELAEKQKKE--EDVSALPTLTVKDIPREGDFYPLDfaDINS 594
Cdd:pfam08367    1 MKPDEGLSEELEEEEKERLAAKKASLSEEEKEKIVERTLELKERQEAPdsEDLSCLPTLTLSDIPREIEVEPEE--EIGG 78
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 199431355   595 KKLQKRIVDTNGLIYMNATKDISYLPSKYYEYLPLFDCCLTNLaGTSKTPITELEIKIQKLTGGVTFNVSAKTDPFDISK 674
Cdd:pfam08367   79 VPVLHHDVPTNGIVYFRAIFDLSDLPEELLPYLPLFTSVLTEL-GTKKYDYEELEQEINLKTGGISASPSVSSDPDDLDK 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 199431355   675 TNMKFMLSGMALKDKSQNVYDLWFEILTQTKFDSEdeqvvDKLFTLVKNLGQNQMNTIADSGHSYANSYSNSQLTPTKYI 754
Cdd:pfam08367  158 YEPGFVVSGKALDRNVPKMFDLLREILLETKFDDK-----ERLKELVQESKSRLENSIASSGHSYAMSRAASYLSPAGAL 232
                          250
                   ....*....|....*.
gi 199431355   755 HNLIGGIGQVSFISDL 770
Cdd:pfam08367  233 SEQLSGLSQYKFLKDL 248
PqqL COG0612
Predicted Zn-dependent peptidase, M16 family [General function prediction only];
82-430 4.59e-20

Predicted Zn-dependent peptidase, M16 family [General function prediction only];


Pssm-ID: 440377 [Multi-domain]  Cd Length: 427  Bit Score: 94.22  E-value: 4.59e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 199431355   82 PNDKNNVFSVAFKTNA------PDATGVPHILEHTTLCGSFKYPVRDpFFKMLNRsLSNFMNAMTGHDYTYYpFATTNAK 155
Cdd:COG0612    30 PDPEAPVVSVRLWVRVgsrdepPGKTGLAHFLEHMLFKGTKKRSAGE-IAEELEA-LGGSLNAFTSFDYTVY-YLSVLSE 106
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 199431355  156 DFENLMDVYLSSVFEPLLThesfmQEGWRLEnsdlsdpkspiifKGVVYNEMKGQYSNSAYYYWIKFQEAIYGS---LNN 232
Cdd:COG0612   107 DLELALELLADRLLNPTFD-----EEELERE-------------RGVVLEEIRRYEDDPDGLAFEALLAALYGDhpyGRP 168
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 199431355  233 SGGNPNEITDLRYEDLVDFHSSNYHPSNAKTFTYGNIELVNHLNKLNEFFESFGSRGirTNVRKPITELNPNYESDVTVK 312
Cdd:COG0612   169 IIGTEESIEAITREDLRAFYKRYYRPNNAVLVVVGDVDPEEVLALVEKYFGDLPAGP--APPRPDPAEPPQTGPRRVVVD 246
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 199431355  313 gpldtmssRPIEEQYKSSITWVIGNPLDEsklyDVFKWKVLSSLLCDGHNSPFYQELIEKE---YGedFAVNYGLDATTA 389
Cdd:COG0612   247 --------DPDAEQAHILLGYPGPARDDP----DYYALDVLNEILGGGFSSRLFQELREKKglaYS--VGSSFSPYRDAG 312
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|...
gi 199431355  390 LLSFTIGLNNLSLEKAKNLEDKVRGIFVEKIIP--ELQKGKES 430
Cdd:COG0612   313 LFTIYAGTAPDKLEEALAAILEELERLAKEGVTeeELERAKNQ 355
Peptidase_M16_C pfam05193
Peptidase M16 inactive domain; Peptidase M16 consists of two structurally related domains. One ...
242-443 8.05e-15

Peptidase M16 inactive domain; Peptidase M16 consists of two structurally related domains. One is the active peptidase, whereas the other is inactive. The two domains hold the substrate like a clamp.


Pssm-ID: 428362 [Multi-domain]  Cd Length: 181  Bit Score: 73.58  E-value: 8.05e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 199431355   242 DLRYEDLVDFHSSNYHPSNAKTFTYGNIELVNHLNKLNEFFESFGSRgIRTNVRKPITELNPNYESDVTVKGPLdtmssr 321
Cdd:pfam05193    1 SLTREDLRDFYKKHYSPDNMVLVIVGDVDHEELLDLAEKYFGDLPAS-PKGKPRPPPLEPAKLKGREVVVPKKD------ 73
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 199431355   322 piEEQYKSSITWVIGNPLDEsklYDVFKWKVLSSLLCDGHNSPFYQELIEKE-YGEDFAVNYGLDATTALLSFTIGLNNL 400
Cdd:pfam05193   74 --EPQAHLALAFPGPPLNND---EDSLALDVLNELLGGGMSSRLFQELREKEgLAYSVSSFNDSYSDSGLFGIYATVDPE 148
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....
gi 199431355   401 SLEKAknledkvrgifVEKIIPELQKGKESGFND-RIEAILHQI 443
Cdd:pfam05193  149 NVDEV-----------IELILEELEKLAQEGVTEeELERAKNQL 181
PqqL COG0612
Predicted Zn-dependent peptidase, M16 family [General function prediction only];
865-1048 4.58e-05

Predicted Zn-dependent peptidase, M16 family [General function prediction only];


Pssm-ID: 440377 [Multi-domain]  Cd Length: 427  Bit Score: 47.23  E-value: 4.58e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 199431355  865 GRSTLIDLPFQVGYASLAKLGAAYTSKDGAALRVLSQLLTFKH---LHSVIREANG-AYGGGLSFDglggclnfySYRDP 940
Cdd:COG0612   241 RRVVVDDPDAEQAHILLGYPGPARDDPDYYALDVLNEILGGGFssrLFQELREKKGlAYSVGSSFS---------PYRDA 311
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 199431355  941 NPLT-SVQSFKDSTSVALgKMINSE-----NNGWSPKDLQEAKLTIFQGV----DAPSHISSQGSLDFLEHITDEMRQER 1010
Cdd:COG0612   312 GLFTiYAGTAPDKLEEAL-AAILEElerlaKEGVTEEELERAKNQLLGSLalslESNSGLASQLGRYELYGGDLDYLEEY 390
                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 199431355 1011 RERFLDVTYEDLKNVTEKYlLNGSQDIVTVIGDNETLK 1048
Cdd:COG0612   391 LERIEAVTAEDVQAVARKY-LDPDNLVVVVVGPKKKAE 427
Peptidase_M16 pfam00675
Insulinase (Peptidase family M16);
98-174 8.75e-03

Insulinase (Peptidase family M16);


Pssm-ID: 425812 [Multi-domain]  Cd Length: 149  Bit Score: 38.06  E-value: 8.75e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 199431355    98 PDATGVPHILEHTTLCGSFKYPVR--DPFFKMLNRSLsnfmNAMTGHDYTYYpFATTNAKDFENLMDVYLSSVFEPLLT 174
Cdd:pfam00675   28 DNNNGLAHFLEHMAFKGTKKYPSNelEEELEKLGGSL----NAFTSRENTVY-YAEVLNDDLPKAVDRLADFFRNPLFT 101
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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