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Conserved domains on  [gi|2132167886|emb|CAG8703681|]
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11108_t:CDS:2, partial [Ambispora leptoticha]

Protein Classification

glucose-6-phosphate 1-dehydrogenase( domain architecture ID 1000188)

glucose-6-phosphate 1-dehydrogenase (G6PD) catalyzes the first and rate-limiting step of the oxidative branch within the pentose phosphate pathway/shunt, an alternative route to glycolysis for the dissimilation of carbohydrates and a major source of reducing power and metabolic intermediates for fatty acid and nucleic acid biosynthetic processes

EC:  1.1.1.-
Gene Ontology:  GO:0006006|GO:0050661|GO:0016614

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PTZ00309 super family cl29403
glucose-6-phosphate 1-dehydrogenase; Provisional
 11-365 0e+00

glucose-6-phosphate 1-dehydrogenase; Provisional


The actual alignment was detected with superfamily member PTZ00309:

Pssm-ID: 240353 [Multi-domain]  Cd Length: 542  Bit Score: 555.90  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2132167886  11 QTTIVVLGASGDLAKKKTFPALFGLYRNGFLSENTHIVGYARSKMDLAQFRQRISQF-IKTPVEEVKKQLGEFLELCTYI 89
Cdd:PTZ00309   54 ALTIIVLGASGDLAKKKTFPALFQLYCEGLLPSEVNIVGYARSKMSDVERWKKETLArFFKRLDDRECHLEQFLKHISYI 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2132167886  90 SGPYDVDEGYQHLNEEFEKIEKDIPGDK---NRVFYMALPPSVFIQVAKGLKKNVYSTKGINRLIVEKPFGMDLESSREL 166
Cdd:PTZ00309  134 SGSYDEDEDFKRLNKLIERMEEAFQGPEkggNRLFYLALPPSVFASVCEGIHRGCMSKNGWVRVIVEKPFGRDLESSEEL 213

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2132167886 167 GKALAPLWAEEETYRIDHYLGKEMVKNLLIIRFANVFFGSIWNRHSIANIQITFKETIGTEGRGGYFDEFGIIRDVMQNH 246
Cdd:PTZ00309  214 SNQLEPLFDESQLYRIDHYLGKEMVQNLIVLRFANRVFEPLWNRNNIACVQITFKEDIGTEGRGGYFDSYGIIRDVMQNH 293

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2132167886 247 LLQILSIVAMDTPVSLDAEDVRDEKVRVLRCIQPVKSEDTILGQYVKSEDGSKPGYLDDETVPKDSNCPTFAAATLWINN 326
Cdd:PTZ00309  294 LLQILALLAMEKPVSLSAEDIRDEKVKVLKCIEPIKMEECVLGQYTASADGSIPGYLEDEGVPKDSTTPTFAAAVLHINN 373

                         330       340       350
                  ....*....|....*....|....*....|....*....
gi 2132167886 327 ERWEGVPFILKCGKALNEAKTEVRIQFRDVPGSIFKDAA 365
Cdd:PTZ00309  374 DRWEGVPFILEAGKALEERYVEIRIQFKGVDEFRPSGDD 412
 
Name Accession Description Interval E-value
PTZ00309 PTZ00309
glucose-6-phosphate 1-dehydrogenase; Provisional
 11-365 0e+00

glucose-6-phosphate 1-dehydrogenase; Provisional


Pssm-ID: 240353 [Multi-domain]  Cd Length: 542  Bit Score: 555.90  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2132167886  11 QTTIVVLGASGDLAKKKTFPALFGLYRNGFLSENTHIVGYARSKMDLAQFRQRISQF-IKTPVEEVKKQLGEFLELCTYI 89
Cdd:PTZ00309   54 ALTIIVLGASGDLAKKKTFPALFQLYCEGLLPSEVNIVGYARSKMSDVERWKKETLArFFKRLDDRECHLEQFLKHISYI 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2132167886  90 SGPYDVDEGYQHLNEEFEKIEKDIPGDK---NRVFYMALPPSVFIQVAKGLKKNVYSTKGINRLIVEKPFGMDLESSREL 166
Cdd:PTZ00309  134 SGSYDEDEDFKRLNKLIERMEEAFQGPEkggNRLFYLALPPSVFASVCEGIHRGCMSKNGWVRVIVEKPFGRDLESSEEL 213

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2132167886 167 GKALAPLWAEEETYRIDHYLGKEMVKNLLIIRFANVFFGSIWNRHSIANIQITFKETIGTEGRGGYFDEFGIIRDVMQNH 246
Cdd:PTZ00309  214 SNQLEPLFDESQLYRIDHYLGKEMVQNLIVLRFANRVFEPLWNRNNIACVQITFKEDIGTEGRGGYFDSYGIIRDVMQNH 293

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2132167886 247 LLQILSIVAMDTPVSLDAEDVRDEKVRVLRCIQPVKSEDTILGQYVKSEDGSKPGYLDDETVPKDSNCPTFAAATLWINN 326
Cdd:PTZ00309  294 LLQILALLAMEKPVSLSAEDIRDEKVKVLKCIEPIKMEECVLGQYTASADGSIPGYLEDEGVPKDSTTPTFAAAVLHINN 373

                         330       340       350
                  ....*....|....*....|....*....|....*....
gi 2132167886 327 ERWEGVPFILKCGKALNEAKTEVRIQFRDVPGSIFKDAA 365
Cdd:PTZ00309  374 DRWEGVPFILEAGKALEERYVEIRIQFKGVDEFRPSGDD 412
zwf TIGR00871
glucose-6-phosphate 1-dehydrogenase; This enzyme (EC 1.1.1.49) acts on glucose 6-phospate and ...
 14-363 0e+00

glucose-6-phosphate 1-dehydrogenase; This enzyme (EC 1.1.1.49) acts on glucose 6-phospate and reduces NADP(+). An alternate name appearing in the literature for the human enzyme, based on a slower activity with beta-D-glucose, is glucose 1-dehydrogenase (EC 1.1.1.47), but that name more properly describes a subfamily of the short chain dehydrogenases/reductases family. This is a well-studied enzyme family, with sequences available from well over 50 species. The trusted cutoff is set above the score for the Drosophila melanogaster CG7140 gene product, a homolog of unknown function. G6PD homologs from the bacteria Aquifex aeolicus and Helicobacter pylori lack several motifs well conserved most other members, were omitted from the seed alignment, and score well below the trusted cutoff. [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 273312 [Multi-domain]  Cd Length: 487  Bit Score: 534.21  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2132167886  14 IVVLGASGDLAKKKTFPALFGLYRNGFLSENTHIVGYARSKMDLAQFRQRISQ-FIKTPVEEVKKQLGEFLELCTYISGP 92
Cdd:TIGR00871   5 LVIFGASGDLARKKLFPALYRLFRNGLLPPDFRIVGVARRDWSVEEFRKVVREaIIKFETDEIDEQWDEFAQRLSYVSGD 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2132167886  93 YDVDEGYQHLNEEFEKIEKDIPGDKNRVFYMALPPSVFIQVAKGLKKNVYSTKG-INRLIVEKPFGMDLESSRELGKALA 171
Cdd:TIGR00871  85 VDDDESYDSLAELLEQLDKTYGTEGNRLFYLATPPSLFGTIIKQLKKHGLNEQGkWSRVVVEKPFGHDLASAQELNKALR 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2132167886 172 PLWAEEETYRIDHYLGKEMVKNLLIIRFANVFFGSIWNRHSIANIQITFKETIGTEGRGGYFDEFGIIRDVMQNHLLQIL 251
Cdd:TIGR00871 165 AVFKEDQIYRIDHYLGKETVQNLLVLRFANQIFEPLWNRRYIDHVQITVAESFGVEGRGGYYDKSGALRDMVQNHLLQLL 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2132167886 252 SIVAMDTPVSLDAEDVRDEKVRVLRCIQPVKSED--TILGQYVKSEDG--SKPGYLDDETVPKDSNCPTFAAATLWINNE 327
Cdd:TIGR00871 245 ALVAMEPPVSFDADSIRDEKVKVLKALRPIDPDDnnTVRGQYGAGEIGgvSVPGYLEEEGVDKDSNTETFAALKLEIDNW 324

                         330       340       350
                  ....*....|....*....|....*....|....*.
gi 2132167886 328 RWEGVPFILKCGKALNEAKTEVRIQFRDVPGSIFKD 363
Cdd:TIGR00871 325 RWAGVPFYLRTGKRLPEKVTEIRIQFRDVPSLLFKA 360
Zwf COG0364
Glucose-6-phosphate 1-dehydrogenase [Carbohydrate transport and metabolism]; ...
 12-365 1.70e-163

Glucose-6-phosphate 1-dehydrogenase [Carbohydrate transport and metabolism]; Glucose-6-phosphate 1-dehydrogenase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440133 [Multi-domain]  Cd Length: 495  Bit Score: 466.47  E-value: 1.70e-163
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2132167886  12 TTIVVLGASGDLAKKKTFPALFGLYRNGFLSENTHIVGYARSKMDLAQFRQR----ISQFIKTPVEEvkKQLGEFLELCT 87
Cdd:COG0364    10 CDLVIFGATGDLARRKLLPALYNLYRDGLLPEGFRIIGVARRDWSDEEFREEvreaLEEFSRKPFDE--EVWERFLERLH 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2132167886  88 YISGPYDVDEGYQHLNEEFEKIEKDIPGDkNRVFYMALPPSVFIQVAKGLKK-NVYSTKGINRLIVEKPFGMDLESSREL 166
Cdd:COG0364    88 YVSGDFTDPEGYERLKELLEELDEERTPG-NRVFYLATPPSLFGPICENLGAaGLATEGGWRRVVIEKPFGHDLASAREL 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2132167886 167 GKALAPLWAEEETYRIDHYLGKEMVKNLLIIRFANVFFGSIWNRHSIANIQITFKETIGTEGRGGYFDEFGIIRDVMQNH 246
Cdd:COG0364   167 NDELGRVFDESQIYRIDHYLGKETVQNLLALRFANALFEPLWNRNYIDHVQITVAETVGVEGRGGYYDGAGALRDMVQNH 246

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2132167886 247 LLQILSIVAMDTPVSLDAEDVRDEKVRVLRCIQPVKSED----TILGQYVKSEDGSK--PGYLDDETVPKDSNCPTFAAA 320
Cdd:COG0364   247 LLQLLCLVAMEPPASLDADAIRDEKVKVLRALRPITPEDvaenTVRGQYTAGWIGGEpvPGYREEPGVAPDSTTETFVAL 326

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*
gi 2132167886 321 TLWINNERWEGVPFILKCGKALNEAKTEVRIQFRDVPGSIFKDAA 365
Cdd:COG0364   327 KLEIDNWRWAGVPFYLRTGKRLPERVTEIVIQFKPVPHSLFRETA 371
G6PD_C pfam02781
Glucose-6-phosphate dehydrogenase, C-terminal domain;
195-363 1.46e-109

Glucose-6-phosphate dehydrogenase, C-terminal domain;


Pssm-ID: 460694  Cd Length: 295  Bit Score: 322.08  E-value: 1.46e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2132167886 195 LIIRFANVFFGSIWNRHSIANIQITFKETIGTEGRGGYFDEFGIIRDVMQNHLLQILSIVAMDTPVSLDAEDVRDEKVRV 274
Cdd:pfam02781   1 LVLRFANAIFEPLWNRNYIDHVQITVAETLGVEGRGGYYDQAGALRDMVQNHLLQLLALVAMEPPVSFDAEDIRDEKVKV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2132167886 275 LRCIQPVKSED----TILGQYVKSEDG--SKPGYLDDETVPKDSNCPTFAAATLWINNERWEGVPFILKCGKALNEAKTE 348
Cdd:pfam02781  81 LRSLRPITPEDvednVVRGQYGAGWIGgePVPGYREEEGVPPDSRTETFAALKLFIDNWRWAGVPFYLRTGKRLPERVTE 160

                         170
                  ....*....|....*
gi 2132167886 349 VRIQFRDVPGSIFKD 363
Cdd:pfam02781 161 IRIQFKDVPHNLFRD 175
 
Name Accession Description Interval E-value
PTZ00309 PTZ00309
glucose-6-phosphate 1-dehydrogenase; Provisional
 11-365 0e+00

glucose-6-phosphate 1-dehydrogenase; Provisional


Pssm-ID: 240353 [Multi-domain]  Cd Length: 542  Bit Score: 555.90  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2132167886  11 QTTIVVLGASGDLAKKKTFPALFGLYRNGFLSENTHIVGYARSKMDLAQFRQRISQF-IKTPVEEVKKQLGEFLELCTYI 89
Cdd:PTZ00309   54 ALTIIVLGASGDLAKKKTFPALFQLYCEGLLPSEVNIVGYARSKMSDVERWKKETLArFFKRLDDRECHLEQFLKHISYI 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2132167886  90 SGPYDVDEGYQHLNEEFEKIEKDIPGDK---NRVFYMALPPSVFIQVAKGLKKNVYSTKGINRLIVEKPFGMDLESSREL 166
Cdd:PTZ00309  134 SGSYDEDEDFKRLNKLIERMEEAFQGPEkggNRLFYLALPPSVFASVCEGIHRGCMSKNGWVRVIVEKPFGRDLESSEEL 213

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2132167886 167 GKALAPLWAEEETYRIDHYLGKEMVKNLLIIRFANVFFGSIWNRHSIANIQITFKETIGTEGRGGYFDEFGIIRDVMQNH 246
Cdd:PTZ00309  214 SNQLEPLFDESQLYRIDHYLGKEMVQNLIVLRFANRVFEPLWNRNNIACVQITFKEDIGTEGRGGYFDSYGIIRDVMQNH 293

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2132167886 247 LLQILSIVAMDTPVSLDAEDVRDEKVRVLRCIQPVKSEDTILGQYVKSEDGSKPGYLDDETVPKDSNCPTFAAATLWINN 326
Cdd:PTZ00309  294 LLQILALLAMEKPVSLSAEDIRDEKVKVLKCIEPIKMEECVLGQYTASADGSIPGYLEDEGVPKDSTTPTFAAAVLHINN 373

                         330       340       350
                  ....*....|....*....|....*....|....*....
gi 2132167886 327 ERWEGVPFILKCGKALNEAKTEVRIQFRDVPGSIFKDAA 365
Cdd:PTZ00309  374 DRWEGVPFILEAGKALEERYVEIRIQFKGVDEFRPSGDD 412
zwf TIGR00871
glucose-6-phosphate 1-dehydrogenase; This enzyme (EC 1.1.1.49) acts on glucose 6-phospate and ...
 14-363 0e+00

glucose-6-phosphate 1-dehydrogenase; This enzyme (EC 1.1.1.49) acts on glucose 6-phospate and reduces NADP(+). An alternate name appearing in the literature for the human enzyme, based on a slower activity with beta-D-glucose, is glucose 1-dehydrogenase (EC 1.1.1.47), but that name more properly describes a subfamily of the short chain dehydrogenases/reductases family. This is a well-studied enzyme family, with sequences available from well over 50 species. The trusted cutoff is set above the score for the Drosophila melanogaster CG7140 gene product, a homolog of unknown function. G6PD homologs from the bacteria Aquifex aeolicus and Helicobacter pylori lack several motifs well conserved most other members, were omitted from the seed alignment, and score well below the trusted cutoff. [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 273312 [Multi-domain]  Cd Length: 487  Bit Score: 534.21  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2132167886  14 IVVLGASGDLAKKKTFPALFGLYRNGFLSENTHIVGYARSKMDLAQFRQRISQ-FIKTPVEEVKKQLGEFLELCTYISGP 92
Cdd:TIGR00871   5 LVIFGASGDLARKKLFPALYRLFRNGLLPPDFRIVGVARRDWSVEEFRKVVREaIIKFETDEIDEQWDEFAQRLSYVSGD 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2132167886  93 YDVDEGYQHLNEEFEKIEKDIPGDKNRVFYMALPPSVFIQVAKGLKKNVYSTKG-INRLIVEKPFGMDLESSRELGKALA 171
Cdd:TIGR00871  85 VDDDESYDSLAELLEQLDKTYGTEGNRLFYLATPPSLFGTIIKQLKKHGLNEQGkWSRVVVEKPFGHDLASAQELNKALR 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2132167886 172 PLWAEEETYRIDHYLGKEMVKNLLIIRFANVFFGSIWNRHSIANIQITFKETIGTEGRGGYFDEFGIIRDVMQNHLLQIL 251
Cdd:TIGR00871 165 AVFKEDQIYRIDHYLGKETVQNLLVLRFANQIFEPLWNRRYIDHVQITVAESFGVEGRGGYYDKSGALRDMVQNHLLQLL 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2132167886 252 SIVAMDTPVSLDAEDVRDEKVRVLRCIQPVKSED--TILGQYVKSEDG--SKPGYLDDETVPKDSNCPTFAAATLWINNE 327
Cdd:TIGR00871 245 ALVAMEPPVSFDADSIRDEKVKVLKALRPIDPDDnnTVRGQYGAGEIGgvSVPGYLEEEGVDKDSNTETFAALKLEIDNW 324

                         330       340       350
                  ....*....|....*....|....*....|....*.
gi 2132167886 328 RWEGVPFILKCGKALNEAKTEVRIQFRDVPGSIFKD 363
Cdd:TIGR00871 325 RWAGVPFYLRTGKRLPEKVTEIRIQFRDVPSLLFKA 360
PLN02539 PLN02539
glucose-6-phosphate 1-dehydrogenase
 9-362 4.28e-179

glucose-6-phosphate 1-dehydrogenase


Pssm-ID: 178154 [Multi-domain]  Cd Length: 491  Bit Score: 506.18  E-value: 4.28e-179
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2132167886   9 TGQTTIVVLGASGDLAKKKTFPALFGLYRNGFLSENT-HIVGYARSKMDLAQFRQRISQFIKTPVEEVKKQLGEFLELCT 87
Cdd:PLN02539   15 TGCLSIIVLGASGDLAKKKTFPALFNLYRQGFLPPDEvHIFGYARSKITDEELRDRIRGYLKDEKNAPAEAVSKFLQLIK 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2132167886  88 YISGPYDVDEGYQHLNEE---FEKIEKDIPGDKNRVFYMALPPSVFIQVAKGLKKNVYSTKGI-NRLIVEKPFGMDLESS 163
Cdd:PLN02539   95 YVSGAYDSEEGFRRLDKEiseHEISKNSAEGSSRRLFYLALPPSVYPPVCKMIKKCCMNKSGLwTRIVVEKPFGKDLESA 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2132167886 164 RELGKALAPLWAEEETYRIDHYLGKEMVKNLLIIRFANVFFGSIWNRHSIANIQITFKETIGTEGRGGYFDEFGIIRDVM 243
Cdd:PLN02539  175 EELSSQIGELFDESQLYRIDHYLGKELVQNLLVLRFANRFFLPLWNRDNIANVQIVFREDFGTEGRGGYFDEYGIIRDII 254

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2132167886 244 QNHLLQILSIVAMDTPVSLDAEDVRDEKVRVLRCIQPVKSEDTILGQYvksedgskPGYLDDETVPKDSNCPTFAAATLW 323
Cdd:PLN02539  255 QNHLLQVLCLVAMEKPVSLKPEHIRDEKVKVLQSVEPIKDEEVVLGQY--------EGYRDDPTVPDDSNTPTFASVVLR 326

                         330       340       350
                  ....*....|....*....|....*....|....*....
gi 2132167886 324 INNERWEGVPFILKCGKALNEAKTEVRIQFRDVPGSIFK 362
Cdd:PLN02539  327 INNERWEGVPFILKAGKALDSRKAEIRVQFKDVPGDIFK 365
Zwf COG0364
Glucose-6-phosphate 1-dehydrogenase [Carbohydrate transport and metabolism]; ...
 12-365 1.70e-163

Glucose-6-phosphate 1-dehydrogenase [Carbohydrate transport and metabolism]; Glucose-6-phosphate 1-dehydrogenase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440133 [Multi-domain]  Cd Length: 495  Bit Score: 466.47  E-value: 1.70e-163
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2132167886  12 TTIVVLGASGDLAKKKTFPALFGLYRNGFLSENTHIVGYARSKMDLAQFRQR----ISQFIKTPVEEvkKQLGEFLELCT 87
Cdd:COG0364    10 CDLVIFGATGDLARRKLLPALYNLYRDGLLPEGFRIIGVARRDWSDEEFREEvreaLEEFSRKPFDE--EVWERFLERLH 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2132167886  88 YISGPYDVDEGYQHLNEEFEKIEKDIPGDkNRVFYMALPPSVFIQVAKGLKK-NVYSTKGINRLIVEKPFGMDLESSREL 166
Cdd:COG0364    88 YVSGDFTDPEGYERLKELLEELDEERTPG-NRVFYLATPPSLFGPICENLGAaGLATEGGWRRVVIEKPFGHDLASAREL 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2132167886 167 GKALAPLWAEEETYRIDHYLGKEMVKNLLIIRFANVFFGSIWNRHSIANIQITFKETIGTEGRGGYFDEFGIIRDVMQNH 246
Cdd:COG0364   167 NDELGRVFDESQIYRIDHYLGKETVQNLLALRFANALFEPLWNRNYIDHVQITVAETVGVEGRGGYYDGAGALRDMVQNH 246

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2132167886 247 LLQILSIVAMDTPVSLDAEDVRDEKVRVLRCIQPVKSED----TILGQYVKSEDGSK--PGYLDDETVPKDSNCPTFAAA 320
Cdd:COG0364   247 LLQLLCLVAMEPPASLDADAIRDEKVKVLRALRPITPEDvaenTVRGQYTAGWIGGEpvPGYREEPGVAPDSTTETFVAL 326

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*
gi 2132167886 321 TLWINNERWEGVPFILKCGKALNEAKTEVRIQFRDVPGSIFKDAA 365
Cdd:COG0364   327 KLEIDNWRWAGVPFYLRTGKRLPERVTEIVIQFKPVPHSLFRETA 371
PRK05722 PRK05722
glucose-6-phosphate 1-dehydrogenase; Validated
 13-365 2.05e-163

glucose-6-phosphate 1-dehydrogenase; Validated


Pssm-ID: 235579 [Multi-domain]  Cd Length: 495  Bit Score: 466.53  E-value: 2.05e-163
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2132167886  13 TIVVLGASGDLAKKKTFPALFGLYRNGFLSENTHIVGYARSKMDLAQFRQR----ISQFIKTPVEEvkKQLGEFLELCTY 88
Cdd:PRK05722   11 DLVIFGATGDLARRKLLPALYNLYKAGLLPEDFRIIGVARRDWSDEDFREVvreaLKEFARTPFDE--EVWERFLSRLYY 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2132167886  89 ISGPYDVDEGYQHLNEEFEKIEKDIPGDKNRVFYMALPPSVFIQVAKGLKK-NVYSTKGINRLIVEKPFGMDLESSRELG 167
Cdd:PRK05722   89 VSGDVTDPESYERLKELLEELDEERGTGGNRVFYLATPPSLFGTICENLAAaGLNEGGGWRRVVIEKPFGHDLASARELN 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2132167886 168 KALAPLWAEEETYRIDHYLGKEMVKNLLIIRFANVFFGSIWNRHSIANIQITFKETIGTEGRGGYFDEFGIIRDVMQNHL 247
Cdd:PRK05722  169 DQVGEVFKEEQIYRIDHYLGKETVQNLLALRFANALFEPLWNRNYIDHVQITVAETVGVEGRGGYYDKSGALRDMVQNHL 248

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2132167886 248 LQILSIVAMDTPVSLDAEDVRDEKVRVLRCIQPVKSED----TILGQYVKSEDGSK--PGYLDDETVPKDSNCPTFAAAT 321
Cdd:PRK05722  249 LQLLALVAMEPPASLDADSIRDEKVKVLRALRPITPEDvkenTVRGQYTAGWIGGKpvPGYREEEGVNPDSTTETFVALK 328

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 2132167886 322 LWINNERWEGVPFILKCGKALNEAKTEVRIQFRDVPGSIFKDAA 365
Cdd:PRK05722  329 LEIDNWRWAGVPFYLRTGKRLPKKVTEIVIVFKPPPHNLFEESA 372
PLN02640 PLN02640
glucose-6-phosphate 1-dehydrogenase
 13-362 3.27e-144

glucose-6-phosphate 1-dehydrogenase


Pssm-ID: 215344 [Multi-domain]  Cd Length: 573  Bit Score: 420.57  E-value: 3.27e-144
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2132167886  13 TIVVLGASGDLAKKKTFPALFGLYRNGFLSENTHIVGYARSKMDLAQFRQRISQFIKTPVEEVKK---QLGEFLELCTYI 89
Cdd:PLN02640   90 SITVVGASGDLAKKKIFPALFALFYEDWLPENFTVFGYARTKLTDEELRDMISSTLTCRIDQRENcgdKMDQFLKRCFYH 169

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2132167886  90 SGPYDVDEGYQHLNEEFEkiEKDIPGDKNRVFYMALPPSVFIQVAKGLKKNVYSTKGINRLIVEKPFGMDLESSRELGKA 169
Cdd:PLN02640  170 SGQYDSEEDFAELNKKLK--EKEAGKLSNRLFYLSIPPNIFVDVVRCASLRASSENGWTRVIVEKPFGRDSESSGELTRC 247

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2132167886 170 LAPLWAEEETYRIDHYLGKEMVKNLLIIRFANVFFGSIWNRHSIANIQITFKETIGTEGRGGYFDEFGIIRDVMQNHLLQ 249
Cdd:PLN02640  248 LKQYLTEEQIFRIDHYLGKELVENLSVLRFSNLVFEPLWSRNYIRNVQLIFSEDFGTEGRGGYFDNYGIIRDIMQNHLLQ 327

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2132167886 250 ILSIVAMDTPVSLDAEDVRDEKVRVLRCIQPVKSEDTILGQYVKSEDGSK--PGYLDDETVPKDSNCPTFAAATLWINNE 327
Cdd:PLN02640  328 ILALFAMETPVSLDAEDIRNEKVKVLRSMKPLQLEDVIVGQYKGHSKGGKsyPAYTDDPTVPKHSLTPTFAAAALFINNA 407

                         330       340       350
                  ....*....|....*....|....*....|....*
gi 2132167886 328 RWEGVPFILKCGKALNEAKTEVRIQFRDVPGSIFK 362
Cdd:PLN02640  408 RWDGVPFLMKAGKALHTRRAEIRVQFRHVPGNLYK 442
PLN02333 PLN02333
glucose-6-phosphate 1-dehydrogenase
 13-361 1.85e-143

glucose-6-phosphate 1-dehydrogenase


Pssm-ID: 215191 [Multi-domain]  Cd Length: 604  Bit Score: 419.38  E-value: 1.85e-143
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2132167886  13 TIVVLGASGDLAKKKTFPALFGLYRNGFLSENTHIVGYARSKMDLAQFRQRISQFIKTPV---EEVKKQLGEFLELCTYI 89
Cdd:PLN02333  119 SITVVGASGDLAKKKIFPALFALYYEGCLPEHFTIFGYARSKMTDAELRNMVSKTLTCRIdkrENCGEKMEEFLKRCFYH 198

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2132167886  90 SGPYDVDEGYQHLNEEFEKIEkdipGDK--NRVFYMALPPSVFIQVAKGLKKNVYSTKGINRLIVEKPFGMDLESSRELG 167
Cdd:PLN02333  199 SGQYDSQEHFAELDKKLKEHE----GGRvsNRLFYLSIPPNIFVDAVKCASSSASSVNGWTRVIVEKPFGRDSESSAALT 274

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2132167886 168 KALAPLWAEEETYRIDHYLGKEMVKNLLIIRFANVFFGSIWNRHSIANIQITFKETIGTEGRGGYFDEFGIIRDVMQNHL 247
Cdd:PLN02333  275 KSLKQYLEEDQIFRIDHYLGKELVENLSVLRFSNLIFEPLWSRQYIRNVQFIFSEDFGTEGRGGYFDNYGIIRDIMQNHL 354

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2132167886 248 LQILSIVAMDTPVSLDAEDVRDEKVRVLRCIQPVKSEDTILGQYVKSEDG--SKPGYLDDETVPKDSNCPTFAAATLWIN 325
Cdd:PLN02333  355 LQILALFAMETPVSLDAEDIRNEKVKVLRSMRPIQLEDVVIGQYKSHTKGgvTYPAYTDDKTVPKGSLTPTFAAAALFID 434

                         330       340       350
                  ....*....|....*....|....*....|....*.
gi 2132167886 326 NERWEGVPFILKCGKALNEAKTEVRIQFRDVPGSIF 361
Cdd:PLN02333  435 NARWDGVPFLMKAGKALHTKSAEIRVQFRHVPGNLY 470
PRK12853 PRK12853
glucose-6-phosphate dehydrogenase;
12-365 5.14e-143

glucose-6-phosphate dehydrogenase;


Pssm-ID: 237233 [Multi-domain]  Cd Length: 482  Bit Score: 413.91  E-value: 5.14e-143
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2132167886  12 TTIVVLGASGDLAKKKTFPALFGLYRNGFLSENTHIVGYARSKMDLAQFRQR----ISQFIKTPVEEvkKQLGEFLELCT 87
Cdd:PRK12853    9 CTLVIFGATGDLARRKLLPALYRLARAGLLPEDLRIIGVGRDDWSDEQWRARvresLRAFGADGFDD--AVWDRLAARLS 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2132167886  88 YISGPYDVDEGYQHLNEefekiekDIPGDKNRVFYMALPPSVFIQVAKGLKKNVYSTKGInRLIVEKPFGMDLESSRELG 167
Cdd:PRK12853   87 YVQGDVTDPADYARLAE-------ALGPGGNPVFYLAVPPSLFAPVVENLGAAGLLPEGR-RVVLEKPFGHDLASARALN 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2132167886 168 KALAPLWAEEETYRIDHYLGKEMVKNLLIIRFANVFFGSIWNRHSIANIQITFKETIGTEGRGGYFDEFGIIRDVMQNHL 247
Cdd:PRK12853  159 ATLAKVFDEDQIYRIDHFLGKETVQNLLALRFANALLEPLWNRNHIDHVQITVAETLGVEGRGGFYDATGALRDMVQNHL 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2132167886 248 LQILSIVAMDTPVSLDAEDVRDEKVRVLRCIQPVKSED--TILGQYVKSEDGSK--PGYLDDETVPKDSNCPTFAAATLW 323
Cdd:PRK12853  239 LQLLALVAMEPPASFDADAVRDEKAKVLRAIRPLDPDDvhTVRGQYTAGTVGGEpvPGYREEPGVDPDSRTETFVALKLE 318

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|..
gi 2132167886 324 INNERWEGVPFILKCGKALNEAKTEVRIQFRDVPGSIFKDAA 365
Cdd:PRK12853  319 IDNWRWAGVPFYLRTGKRLAERRTEIVITFKPVPHALFRGTG 360
G6PD_C pfam02781
Glucose-6-phosphate dehydrogenase, C-terminal domain;
195-363 1.46e-109

Glucose-6-phosphate dehydrogenase, C-terminal domain;


Pssm-ID: 460694  Cd Length: 295  Bit Score: 322.08  E-value: 1.46e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2132167886 195 LIIRFANVFFGSIWNRHSIANIQITFKETIGTEGRGGYFDEFGIIRDVMQNHLLQILSIVAMDTPVSLDAEDVRDEKVRV 274
Cdd:pfam02781   1 LVLRFANAIFEPLWNRNYIDHVQITVAETLGVEGRGGYYDQAGALRDMVQNHLLQLLALVAMEPPVSFDAEDIRDEKVKV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2132167886 275 LRCIQPVKSED----TILGQYVKSEDG--SKPGYLDDETVPKDSNCPTFAAATLWINNERWEGVPFILKCGKALNEAKTE 348
Cdd:pfam02781  81 LRSLRPITPEDvednVVRGQYGAGWIGgePVPGYREEEGVPPDSRTETFAALKLFIDNWRWAGVPFYLRTGKRLPERVTE 160

                         170
                  ....*....|....*
gi 2132167886 349 VRIQFRDVPGSIFKD 363
Cdd:pfam02781 161 IRIQFKDVPHNLFRD 175
PRK12854 PRK12854
glucose-6-phosphate 1-dehydrogenase; Provisional
 12-365 2.06e-107

glucose-6-phosphate 1-dehydrogenase; Provisional


Pssm-ID: 237234 [Multi-domain]  Cd Length: 484  Bit Score: 323.14  E-value: 2.06e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2132167886  12 TTIVVLGASGDLAKKKTFPALFGLYRNGFLSENTHIVGYARSKMDLAQFRQRI----SQFIKTPVEEvkKQLGEFLELCT 87
Cdd:PRK12854   12 TVFVLFGATGDLAKRKLLPGLFHLARAGLLPPDWRIVGTGRGDVSAEAFREHArdalDEFGARKLDD--GEWARFAKRLR 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2132167886  88 YISGPYDVDEGyQHLNEEFEKIEKDIPGDKNRVFYMALPPSVFIQVAKGLKKnVYSTKGiNRLIVEKPFGMDLESSRELG 167
Cdd:PRK12854   90 YVPGGFLSAGP-GALAAAVAAARAELGGDARLVHYLAVPPSAFLDVTRALGE-AGLAEG-SRVVMEKPFGTDLASAEALN 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2132167886 168 KALAPLWAEEETYRIDHYLGKEMVKNLLIIRFANVFFGSIWNRHSIANIQITFKETIGTEGRGGYFDEFGIIRDVMQNHL 247
Cdd:PRK12854  167 AAVHEVFDESQIFRIDHFLGKEAAQNILAFRFANGLFEPIWNREFIDHVQIDVPETLGVDTRAAFYDATGAYRDMVVTHL 246

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2132167886 248 LQILSIVAMDTPVSLDAEDVRDEKVRVLRCIQPVKSEDTILGQYVksedgskpGYLDDETVPKDSNCPTFAAATLWINNE 327
Cdd:PRK12854  247 FQVLAFVAMEPPTALEPDAISEEKNKVFRSMRPLDPAEVVRGQYS--------GYRDEPGVAPDSTTETFVALKVWIDNW 318

                         330       340       350
                  ....*....|....*....|....*....|....*...
gi 2132167886 328 RWEGVPFILKCGKALNEAKTEVRIQFRDVPGSIFKDAA 365
Cdd:PRK12854  319 RWAGVPFYLRTGKRMAEGQRIISIAFREPPYSMFPAGS 356
G6PD_N pfam00479
Glucose-6-phosphate dehydrogenase, NAD binding domain;
15-193 5.72e-91

Glucose-6-phosphate dehydrogenase, NAD binding domain;


Pssm-ID: 459827 [Multi-domain]  Cd Length: 178  Bit Score: 270.45  E-value: 5.72e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2132167886  15 VVLGASGDLAKKKTFPALFGLYRNGFLSENTHIVGYARSKMDLAQFRQRISQFIKTPVEEVKKQLGEFLELCTYISGPYD 94
Cdd:pfam00479   1 VIFGATGDLAKRKLFPALYNLYRDGLLPEGFRIIGVARRDLSDEEFRERVREALKEFKELDEEKWDRFLERLHYVSGDFD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2132167886  95 VDEGYQHLNEEFEKIEKDIPGdkNRVFYMALPPSVFIQVAKGLKKNVYS-TKGINRLIVEKPFGMDLESSRELGKALAPL 173
Cdd:pfam00479  81 DPESYEKLKERLEEHEDETRG--NRLFYLAVPPSLFGPIAENLGRAGLSeEGGWRRVVIEKPFGHDLESARELNDQLAKV 158

                         170       180
                  ....*....|....*....|
gi 2132167886 174 WAEEETYRIDHYLGKEMVKN 193
Cdd:pfam00479 159 FKEEQIYRIDHYLGKETVQN 178
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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