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Conserved domains on  [gi|51476198|emb|CAH18089|]
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hypothetical protein [Homo sapiens]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12204268)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

CATH:  3.30.160.60|1.10.287.1360
Gene Ontology:  GO:0003677|GO:0008270|GO:0005515|GO:0001217|GO:0003700
PubMed:  8183940|22803940|2023909|8183939|8183940|10748030|27867147|28765213|11361095|30718982|10940247
SCOP:  4003583|4002243

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
4-62 1.77e-30

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 113.07  E-value: 1.77e-30
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 51476198      4 LQFRDVAIEFSLEEWHCLDTAQRNLYRNVMLENYSNLVFLGITVSKPDLITCLEQGRKP 62
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEP 59
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
199-516 4.60e-14

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 74.35  E-value: 4.60e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51476198 199 KPYKCEECGKAFNHSCSLTRHKKIHTGEKPYKC--EECGKAFKHSSTLTTHKRNHTGEKPYKCDKCG------------- 263
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLplsnskassssls 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51476198 264 -------KAFMSSSTLSKHEIIHTEKKPYK--------------------------------CEECGKAFNRSSTLTTHK 304
Cdd:COG5048 112 ssssnsnDNNLLSSHSLPPSSRDPQLPDLLsisnlrnnplpgnnsssvntpqsnslhpplpaNSLSKDPSSNLSLLISSN 191

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51476198 305 IIHTGEKPYKCEECDKAFKYSYTLTTHKRIHTEDkPYKCEECGKAFK-------YSSTLTTHKRIHTGE----------- 366
Cdd:COG5048 192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSS-SLPLTTNSQLSPksllsqsPSSLSSSDSSSSASEsprsslptass 270

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51476198 367 -----------------KPYKCEECGKAFKRSSDLTTHK--IIHTGE--KPYKCEE--CGKAFKYSSNLTTHKKIHTGER 423
Cdd:COG5048 271 qssspnesdsssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSIS 350

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51476198 424 PYKC--EECGKAFNQSSI------LTTHKRIHTGEKFYKCE-ECGKAFKRSSHLTTHKIIHTGEKF--YKCEECDKAFKH 492
Cdd:COG5048 351 PAKEklLNSSSKFSPLLNneppqsLQQYKDLKNDKKSETLSnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNR 430

                       410       420
                ....*....|....*....|....
gi 51476198 493 FSNLTTHKKIHTGKKPYRCEECGK 516
Cdd:COG5048 431 HYNLIPHKKIHTNHAPLLCSILKS 454
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
4-62 1.77e-30

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 113.07  E-value: 1.77e-30
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 51476198      4 LQFRDVAIEFSLEEWHCLDTAQRNLYRNVMLENYSNLVFLGITVSKPDLITCLEQGRKP 62
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEP 59
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 6-44 7.13e-21

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 85.60  E-value: 7.13e-21
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 51476198     6 FRDVAIEFSLEEWHCLDTAQRNLYRNVMLENYSNLVFLG 44
Cdd:pfam01352   4 FEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 6-43 2.88e-18

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 77.97  E-value: 2.88e-18
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 51476198   6 FRDVAIEFSLEEWHCLDTAQRNLYRNVMLENYSNLVFL 43
Cdd:cd07765   3 FEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
199-516 4.60e-14

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 74.35  E-value: 4.60e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51476198 199 KPYKCEECGKAFNHSCSLTRHKKIHTGEKPYKC--EECGKAFKHSSTLTTHKRNHTGEKPYKCDKCG------------- 263
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLplsnskassssls 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51476198 264 -------KAFMSSSTLSKHEIIHTEKKPYK--------------------------------CEECGKAFNRSSTLTTHK 304
Cdd:COG5048 112 ssssnsnDNNLLSSHSLPPSSRDPQLPDLLsisnlrnnplpgnnsssvntpqsnslhpplpaNSLSKDPSSNLSLLISSN 191

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51476198 305 IIHTGEKPYKCEECDKAFKYSYTLTTHKRIHTEDkPYKCEECGKAFK-------YSSTLTTHKRIHTGE----------- 366
Cdd:COG5048 192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSS-SLPLTTNSQLSPksllsqsPSSLSSSDSSSSASEsprsslptass 270

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51476198 367 -----------------KPYKCEECGKAFKRSSDLTTHK--IIHTGE--KPYKCEE--CGKAFKYSSNLTTHKKIHTGER 423
Cdd:COG5048 271 qssspnesdsssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSIS 350

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51476198 424 PYKC--EECGKAFNQSSI------LTTHKRIHTGEKFYKCE-ECGKAFKRSSHLTTHKIIHTGEKF--YKCEECDKAFKH 492
Cdd:COG5048 351 PAKEklLNSSSKFSPLLNneppqsLQQYKDLKNDKKSETLSnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNR 430

                       410       420
                ....*....|....*....|....
gi 51476198 493 FSNLTTHKKIHTGKKPYRCEECGK 516
Cdd:COG5048 431 HYNLIPHKKIHTNHAPLLCSILKS 454
zf-H2C2_2 pfam13465
Zinc-finger double domain;
215-240 1.77e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.77e-04
                          10        20
                  ....*....|....*....|....*.
gi 51476198   215 SLTRHKKIHTGEKPYKCEECGKAFKH 240
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
4-62 1.77e-30

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 113.07  E-value: 1.77e-30
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 51476198      4 LQFRDVAIEFSLEEWHCLDTAQRNLYRNVMLENYSNLVFLGITVSKPDLITCLEQGRKP 62
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEP 59
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 6-44 7.13e-21

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 85.60  E-value: 7.13e-21
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 51476198     6 FRDVAIEFSLEEWHCLDTAQRNLYRNVMLENYSNLVFLG 44
Cdd:pfam01352   4 FEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 6-43 2.88e-18

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 77.97  E-value: 2.88e-18
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 51476198   6 FRDVAIEFSLEEWHCLDTAQRNLYRNVMLENYSNLVFL 43
Cdd:cd07765   3 FEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
199-516 4.60e-14

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 74.35  E-value: 4.60e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51476198 199 KPYKCEECGKAFNHSCSLTRHKKIHTGEKPYKC--EECGKAFKHSSTLTTHKRNHTGEKPYKCDKCG------------- 263
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLplsnskassssls 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51476198 264 -------KAFMSSSTLSKHEIIHTEKKPYK--------------------------------CEECGKAFNRSSTLTTHK 304
Cdd:COG5048 112 ssssnsnDNNLLSSHSLPPSSRDPQLPDLLsisnlrnnplpgnnsssvntpqsnslhpplpaNSLSKDPSSNLSLLISSN 191

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51476198 305 IIHTGEKPYKCEECDKAFKYSYTLTTHKRIHTEDkPYKCEECGKAFK-------YSSTLTTHKRIHTGE----------- 366
Cdd:COG5048 192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSS-SLPLTTNSQLSPksllsqsPSSLSSSDSSSSASEsprsslptass 270

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51476198 367 -----------------KPYKCEECGKAFKRSSDLTTHK--IIHTGE--KPYKCEE--CGKAFKYSSNLTTHKKIHTGER 423
Cdd:COG5048 271 qssspnesdsssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSIS 350

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51476198 424 PYKC--EECGKAFNQSSI------LTTHKRIHTGEKFYKCE-ECGKAFKRSSHLTTHKIIHTGEKF--YKCEECDKAFKH 492
Cdd:COG5048 351 PAKEklLNSSSKFSPLLNneppqsLQQYKDLKNDKKSETLSnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNR 430

                       410       420
                ....*....|....*....|....
gi 51476198 493 FSNLTTHKKIHTGKKPYRCEECGK 516
Cdd:COG5048 431 HYNLIPHKKIHTNHAPLLCSILKS 454
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
227-525 4.92e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.55  E-value: 4.92e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51476198 227 KPYKCEECGKAFKHSSTLTTHKRNHTGEKPYKC--DKCGKAFMSSSTLSKHEIIHTEKKPYKCE---------------- 288
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSkslplsnskassssls 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51476198 289 ECGKAFNRSSTLTTHKIIHTGEKPYKCEECDKAFKYSYTLTTHKRIHTEDKPYKC--------EECGKAFKYSSTLTTHK 360
Cdd:COG5048 112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSlhpplpanSLSKDPSSNLSLLISSN 191

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51476198 361 RIHTGEKPYKCEECGKAFKRSSDLTTHKIIHTgEKPYKCEECGKAFKYSSNLTTHKKIHTGERPYKCEECGKAFNQSSIL 440
Cdd:COG5048 192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASS 270

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51476198 441 TTHKRIHTGE-------KFYKCEECGKAFKRSSHLTTHK--IIHTGEKFYKCEE----CDKAFKHFSNLTTHKKIHTGKK 507
Cdd:COG5048 271 QSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGESLKPFSCpyslCGKLFSRNDALKRHILLHTSIS 350

                       330
                ....*....|....*...
gi 51476198 508 PYRCEECGKAFKHSSKLT 525
Cdd:COG5048 351 PAKEKLLNSSSKFSPLLN 368
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
283-444 4.16e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.86  E-value: 4.16e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51476198 283 KPYKCEECGKAFNRSSTLTTHK--IIHTGE--KPYKCEE--CDKAFKYSYTLTTHKRIHTEDKPYKCEEC-------GKA 349
Cdd:COG5048 288 LPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLnssskfsPLL 367

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51476198 350 FKYSSTLTTHKRIHTGEKPYKCE--ECGKAFKRSSDLTTHKIIHTGEKP--YKCEECGKAFKYSSNLTTHKKIHTGERPY 425
Cdd:COG5048 368 NNEPPQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPL 447

                       170
                ....*....|....*....
gi 51476198 426 KCEECGKAFNQSSILTTHK 444
Cdd:COG5048 448 LCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
311-466 1.83e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.46  E-value: 1.83e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51476198 311 KPYKCEECDKAFKYSYTLTTHKR--IHT--EDKPYKCEE--CGKAFKYSSTLTTHKRIHTGEKPYKC--EECGKAFKRSS 382
Cdd:COG5048 288 LPIKSKQCNISFSRSSPLTRHLRsvNHSgeSLKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLL 367

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51476198 383 D-----LTTHKIIHTGEKPYKCE--ECGKAFKYSSNLTTHKKIHTGERP--YKCEECGKAFNQSSILTTHKRIHTGEKFY 453
Cdd:COG5048 368 NneppqSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPL 447

                       170
                ....*....|...
gi 51476198 454 KCEECGKAFKRSS 466
Cdd:COG5048 448 LCSILKSFRRDLD 460
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
267-539 1.88e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.46  E-value: 1.88e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51476198 267 MSSSTLSKHEIIHTEKKPYKCEECGKAFNRSSTLTTHKIIHTGEKPYKC--EECDKAFKYSYTLTTHKRIHTEDKPYKCE 344
Cdd:COG5048  16 LSSTPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNS 95

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51476198 345 ----------------ECGKAF---------------KYSSTLTTHKRIHTGEKPYK---------------------CE 372
Cdd:COG5048  96 kslplsnskasssslsSSSSNSndnnllsshslppssRDPQLPDLLSISNLRNNPLPgnnsssvntpqsnslhpplpaNS 175

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51476198 373 ECGKAFKRSSDLTTHKIIHTGEKPYKCEECGKAFKYSSNLTTHKKIHTGErPYKCEECGKAFNQSSI----LTTHKRIHT 448
Cdd:COG5048 176 LSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSS-SLPLTTNSQLSPKSLLsqspSSLSSSDSS 254

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51476198 449 GE--KFYKCEECGKAFKRSSHLTTHKIIHTG-EKFYKCEECDKAFKHFSNLTTHK--KIHTGK--KPYRCEE--CGKAFK 519
Cdd:COG5048 255 SSasESPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFS 334

                       330       340
                ....*....|....*....|
gi 51476198 520 HSSKLTTHKRFHTGEKPYRC 539
Cdd:COG5048 335 RNDALKRHILLHTSISPAKE 354
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 225-304 9.63e-06

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 48.18  E-value: 9.63e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51476198 225 GEKPYKCE--ECGKAFKHSSTLTTHKRNhtgekpykcDKCGKAFMSSSTLSKHEIIHTEKKPYKCEECGKAFNRSSTLTT 302
Cdd:COG5189 346 DGKPYKCPveGCNKKYKNQNGLKYHMLH---------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                ..
gi 51476198 303 HK 304
Cdd:COG5189 417 HR 418
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 329-417 3.32e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 46.25  E-value: 3.32e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51476198 329 TTHKRIHTED-KPYKCE--ECGKAFKYSSTLTTHKrihtgekpyKCEECGKAFKRSSDLTTHKIIHTGEKPYKCEECGKA 405
Cdd:COG5189 337 TPSRMLKVKDgKPYKCPveGCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKR 407

                        90
                ....*....|..
gi 51476198 406 FKYSSNLTTHKK 417
Cdd:COG5189 408 YKNLNGLKYHRK 419
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 435-532 6.45e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 45.48  E-value: 6.45e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51476198 435 NQSSILTTHKRIHT-GEKFYKCE--ECGKAFKRSSHLTTHKII-HTGEKFYKCEECDKafkhfsnlttHKKIHTGKKPYR 510
Cdd:COG5189 331 GERNIDTPSRMLKVkDGKPYKCPveGCNKKYKNQNGLKYHMLHgHQNQKLHENPSPEK----------MNIFSAKDKPYR 400

                        90       100
                ....*....|....*....|..
gi 51476198 511 CEECGKAFKHSSKLTTHKRFHT 532
Cdd:COG5189 401 CEVCDKRYKNLNGLKYHRKHSH 422
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 226-338 1.57e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 44.32  E-value: 1.57e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51476198 226 EKPYKCEECGKAFKHSSTLT--THKRNH--TGEKPYKCD--KCGKAFMSSSTLSKHEiihtekkpyKCEECGKAFNRSST 299
Cdd:COG5189 315 KLPCTNSSSNGKLAHGGERNidTPSRMLkvKDGKPYKCPveGCNKKYKNQNGLKYHM---------LHGHQNQKLHENPS 385

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 51476198 300 LTTHKIIHTGEKPYKCEECDKAFKYSYTLTTHkRIHTED 338
Cdd:COG5189 386 PEKMNIFSAKDKPYRCEVCDKRYKNLNGLKYH-RKHSHD 423
zf-H2C2_2 pfam13465
Zinc-finger double domain;
215-240 1.77e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.77e-04
                          10        20
                  ....*....|....*....|....*.
gi 51476198   215 SLTRHKKIHTGEKPYKCEECGKAFKH 240
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 197-252 3.04e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.17  E-value: 3.04e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 51476198 197 GGKPYKCE--ECGKAFNHSCSLTRHKK-------------------IHTGEKPYKCEECGKAFKHSSTLTTHKRNHT 252
Cdd:COG5189 346 DGKPYKCPveGCNKKYKNQNGLKYHMLhghqnqklhenpspekmniFSAKDKPYRCEVCDKRYKNLNGLKYHRKHSH 422
zf-H2C2_2 pfam13465
Zinc-finger double domain;
356-380 5.62e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 5.62e-04
                          10        20
                  ....*....|....*....|....*
gi 51476198   356 LTTHKRIHTGEKPYKCEECGKAFKR 380
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
495-520 7.40e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 7.40e-04
                          10        20
                  ....*....|....*....|....*.
gi 51476198   495 NLTTHKKIHTGKKPYRCEECGKAFKH 520
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
411-436 8.08e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 8.08e-04
                          10        20
                  ....*....|....*....|....*.
gi 51476198   411 NLTTHKKIHTGERPYKCEECGKAFNQ 436
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
383-408 1.94e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.94e-03
                          10        20
                  ....*....|....*....|....*.
gi 51476198   383 DLTTHKIIHTGEKPYKCEECGKAFKY 408
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 334-444 2.04e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.86  E-value: 2.04e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51476198 334 IHTEDKPYKCEECGKAFKYSSTL---TTHKRIHT-GEKPYKCE--ECGKAFKRSSDLTTHKiihtgekpyKCEECGKAFK 407
Cdd:COG5189 311 IDVRKLPCTNSSSNGKLAHGGERnidTPSRMLKVkDGKPYKCPveGCNKKYKNQNGLKYHM---------LHGHQNQKLH 381

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 51476198 408 YSSNLTTHKKIHTGERPYKCEECGKAFNQSSILTTHK 444
Cdd:COG5189 382 ENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKYHR 418
zf-H2C2_2 pfam13465
Zinc-finger double domain;
300-324 2.05e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.05e-03
                          10        20
                  ....*....|....*....|....*
gi 51476198   300 LTTHKIIHTGEKPYKCEECDKAFKY 324
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
440-464 3.20e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.20e-03
                          10        20
                  ....*....|....*....|....*
gi 51476198   440 LTTHKRIHTGEKFYKCEECGKAFKR 464
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
328-352 3.39e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.39e-03
                          10        20
                  ....*....|....*....|....*
gi 51476198   328 LTTHKRIHTEDKPYKCEECGKAFKY 352
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
244-266 3.78e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.78e-03
                          10        20
                  ....*....|....*....|...
gi 51476198   244 LTTHKRNHTGEKPYKCDKCGKAF 266
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
467-492 5.28e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 5.28e-03
                          10        20
                  ....*....|....*....|....*.
gi 51476198   467 HLTTHKIIHTGEKFYKCEECDKAFKH 492
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
188-212 5.76e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 5.76e-03
                          10        20
                  ....*....|....*....|....*
gi 51476198   188 LTTHKKIHTGGKPYKCEECGKAFNH 212
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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